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Patent code US10639284

Compile Data Set for Download or QSAR

Found 329 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM440905
PNG
(US10639284, Compound 3.074)
Show SMILES CCN(CC)CCCC(C)NCc1cc(Cl)c(O[C@H]2CCc3c2cccc3-c2ccccc2F)cc1OCc1cncc(c1)C#N
Show InChI InChI=1S/C38H42ClFN4O2/c1-4-44(5-2)17-9-10-26(3)43-24-29-19-34(39)38(20-37(29)45-25-28-18-27(21-41)22-42-23-28)46-36-16-15-31-30(12-8-13-33(31)36)32-11-6-7-14-35(32)40/h6-8,11-14,18-20,22-23,26,36,43H,4-5,9-10,15-17,24-25H2,1-3H3/t26?,36-/m0/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
Plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with PBS containing 2% BSA...


US Patent US10639284 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM440911
PNG
(US10639284, Compound 3.080)
Show SMILES CN(C)CCCCCNCc1cc(Cl)c(O[C@H]2CCc3c2cccc3-c2ccccc2F)cc1OCc1cncc(c1)C#N
Show InChI InChI=1S/C36H38ClFN4O2/c1-42(2)16-7-3-6-15-40-23-27-18-32(37)36(19-35(27)43-24-26-17-25(20-39)21-41-22-26)44-34-14-13-29-28(10-8-11-31(29)34)30-9-4-5-12-33(30)38/h4-5,8-12,17-19,21-22,34,40H,3,6-7,13-16,23-24H2,1-2H3/t34-/m0/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
Plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with PBS containing 2% BSA...


US Patent US10639284 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM440915
PNG
(US10639284, Compound 3.084)
Show SMILES Fc1ccccc1-c1cccc2[C@H](CCc12)Oc1cc(OCc2cncc(c2)C#N)c(CNCc2cccnn2)cc1Cl
Show InChI InChI=1S/C34H27ClFN5O2/c35-30-14-24(19-39-20-25-5-4-12-40-41-25)33(42-21-23-13-22(16-37)17-38-18-23)15-34(30)43-32-11-10-27-26(7-3-8-29(27)32)28-6-1-2-9-31(28)36/h1-9,12-15,17-18,32,39H,10-11,19-21H2/t32-/m0/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
Plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with PBS containing 2% BSA...


US Patent US10639284 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM440963
PNG
(US10639284, Compound 3.132)
Show SMILES OC(=O)[C@@H]1CCN(Cc2cc(Cl)c(O[C@H]3CCc4c3cccc4-c3ccccc3F)cc2OCc2cncc(c2)C#N)C1
Show InChI InChI=1S/C34H29ClFN3O4/c35-29-13-24(19-39-11-10-23(18-39)34(40)41)32(42-20-22-12-21(15-37)16-38-17-22)14-33(29)43-31-9-8-26-25(5-3-6-28(26)31)27-4-1-2-7-30(27)36/h1-7,12-14,16-17,23,31H,8-11,18-20H2,(H,40,41)/t23-,31+/m1/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
Plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with PBS containing 2% BSA...


US Patent US10639284 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM440641
PNG
(US10639284, Compound 1.009)
Show SMILES O[C@H](CNCc1cc(Cl)c(O[C@H]2CCc3c2cccc3-c2ccccc2)cc1OCc1cncc(c1)C#N)CC(O)=O
Show InChI InChI=1S/C33H30ClN3O5/c34-29-12-24(18-37-19-25(38)13-33(39)40)31(41-20-22-11-21(15-35)16-36-17-22)14-32(29)42-30-10-9-27-26(7-4-8-28(27)30)23-5-2-1-3-6-23/h1-8,11-12,14,16-17,25,30,37-38H,9-10,13,18-20H2,(H,39,40)/t25-,30-/m0/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
Plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with PBS containing 2% BSA...


US Patent US10639284 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM440658
PNG
(US10639284, Compound 2.010)
Show SMILES OC[C@H](NCc1cc(Cl)c(O[C@H]2CCc3c2cccc3-c2cccc(F)c2)cc1OCc1cncc(c1)C#N)C(O)=O
Show InChI InChI=1S/C32H27ClFN3O5/c33-27-11-22(16-37-28(17-38)32(39)40)30(41-18-20-9-19(13-35)14-36-15-20)12-31(27)42-29-8-7-25-24(5-2-6-26(25)29)21-3-1-4-23(34)10-21/h1-6,9-12,14-15,28-29,37-38H,7-8,16-18H2,(H,39,40)/t28-,29-/m0/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
Plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with PBS containing 2% BSA...


US Patent US10639284 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM440680
PNG
(US10639284, Compound 2.031)
Show SMILES CN(C)Cc1cc(Cl)c(O[C@H]2CCc3c2cccc3-c2ccccc2F)cc1OCc1cncc(c1)C#N
Show InChI InChI=1S/C31H27ClFN3O2/c1-36(2)18-22-13-27(32)31(14-30(22)37-19-21-12-20(15-34)16-35-17-21)38-29-11-10-24-23(7-5-8-26(24)29)25-6-3-4-9-28(25)33/h3-9,12-14,16-17,29H,10-11,18-19H2,1-2H3/t29-/m0/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
Plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with PBS containing 2% BSA...


US Patent US10639284 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM440692
PNG
(US10639284, Compound 2.043)
Show SMILES COc1cccc(c1Cl)-c1cccc2[C@H](CCc12)Oc1cc(OCc2cncc(c2)C#N)c(CN[C@@H](CO)C(O)=O)cc1Cl
Show InChI InChI=1S/C33H29Cl2N3O6/c1-42-29-7-3-6-25(32(29)35)22-4-2-5-24-23(22)8-9-28(24)44-31-12-30(43-18-20-10-19(13-36)14-37-15-20)21(11-26(31)34)16-38-27(17-39)33(40)41/h2-7,10-12,14-15,27-28,38-39H,8-9,16-18H2,1H3,(H,40,41)/t27-,28-/m0/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
Plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with PBS containing 2% BSA...


US Patent US10639284 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM440713
PNG
(US10639284, Compound 2.064)
Show SMILES COc1cccc(c1F)-c1cccc2[C@H](CCc12)Oc1cc(OCc2cncc(c2)C#N)c(CN2CC(O)C(C2)C(O)=O)cc1Cl
Show InChI InChI=1S/C35H31ClFN3O6/c1-44-31-7-3-6-26(34(31)37)23-4-2-5-25-24(23)8-9-30(25)46-33-12-32(45-19-21-10-20(13-38)14-39-15-21)22(11-28(33)36)16-40-17-27(35(42)43)29(41)18-40/h2-7,10-12,14-15,27,29-30,41H,8-9,16-19H2,1H3,(H,42,43)/t27?,29?,30-/m0/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
Plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with PBS containing 2% BSA...


US Patent US10639284 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM440751
PNG
(US10639284, Compound 2.098 | US10639284, Compound ...)
Show SMILES C[C@H](NCc1cc(Cl)c(O[C@H]2CCc3c2cccc3-c2ccccc2F)cc1OCc1cncc(c1)C#N)C(O)=O
Show InChI InChI=1S/C32H27ClFN3O4/c1-19(32(38)39)37-17-22-12-27(33)31(13-30(22)40-18-21-11-20(14-35)15-36-16-21)41-29-10-9-24-23(6-4-7-26(24)29)25-5-2-3-8-28(25)34/h2-8,11-13,15-16,19,29,37H,9-10,17-18H2,1H3,(H,38,39)/t19-,29-/m0/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
Plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with PBS containing 2% BSA...


US Patent US10639284 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM440760
PNG
(US10639284, Compound 2.107)
Show SMILES COc1cccc(c1F)-c1cccc2[C@H](CCc12)Oc1cc(OCc2cncc(c2)C#N)c(CN[C@H](CO)C(O)=O)cc1Cl
Show InChI InChI=1S/C33H29ClFN3O6/c1-42-29-7-3-6-25(32(29)35)22-4-2-5-24-23(22)8-9-28(24)44-31-12-30(43-18-20-10-19(13-36)14-37-15-20)21(11-26(31)34)16-38-27(17-39)33(40)41/h2-7,10-12,14-15,27-28,38-39H,8-9,16-18H2,1H3,(H,40,41)/t27-,28+/m1/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
Plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with PBS containing 2% BSA...


US Patent US10639284 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM440817
PNG
(US10639284, Compound 2.164)
Show SMILES CCOc1cc(O[C@H]2CCc3c2cccc3-c2ccccc2F)c(Cl)cc1CNC(CO)(CO)CO
Show InChI InChI=1S/C28H31ClFNO5/c1-2-35-26-13-27(23(29)12-18(26)14-31-28(15-32,16-33)17-34)36-25-11-10-20-19(7-5-8-22(20)25)21-6-3-4-9-24(21)30/h3-9,12-13,25,31-34H,2,10-11,14-17H2,1H3/t25-/m0/s1
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US Patent


Assay Description
Plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with PBS containing 2% BSA...


US Patent US10639284 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM440833
PNG
(US10639284, Compound 3.002)
Show SMILES OC[C@H](NCc1cc(Cl)c(O[C@H]2CCc3c2cccc3-c2ccc3OCCOc3c2)cc1OCc1cc(cc(c1)C#N)C#N)C(O)=O
Show InChI InChI=1S/C36H30ClN3O7/c37-29-13-25(18-40-30(19-41)36(42)43)33(46-20-23-11-21(16-38)10-22(12-23)17-39)15-34(29)47-31-7-5-27-26(2-1-3-28(27)31)24-4-6-32-35(14-24)45-9-8-44-32/h1-4,6,10-15,30-31,40-41H,5,7-9,18-20H2,(H,42,43)/t30-,31-/m0/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
Plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with PBS containing 2% BSA...


US Patent US10639284 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM440835
PNG
(US10639284, Compound 3.004)
Show SMILES OC[C@H](NCc1cc(Cl)c(O[C@H]2CCc3c2cccc3-c2ccccc2F)cc1OCc1cc(cc(c1)C#N)C#N)C(O)=O
Show InChI InChI=1S/C34H27ClFN3O5/c35-28-13-23(17-39-30(18-40)34(41)42)32(43-19-22-11-20(15-37)10-21(12-22)16-38)14-33(28)44-31-9-8-25-24(5-3-6-27(25)31)26-4-1-2-7-29(26)36/h1-7,10-14,30-31,39-40H,8-9,17-19H2,(H,41,42)/t30-,31-/m0/s1
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US Patent


Assay Description
Plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with PBS containing 2% BSA...


US Patent US10639284 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM440842
PNG
(US10639284, Compound 3.011)
Show SMILES OC[C@H](NCc1cc(Cl)c(O[C@H]2CCc3c2cccc3-c2cc3OCCOc3c(F)c2F)cc1OCc1cncc(c1)C#N)C(O)=O
Show InChI InChI=1S/C34H28ClF2N3O7/c35-25-9-20(15-40-26(16-41)34(42)43)28(46-17-19-8-18(12-38)13-39-14-19)11-29(25)47-27-5-4-22-21(2-1-3-23(22)27)24-10-30-33(32(37)31(24)36)45-7-6-44-30/h1-3,8-11,13-14,26-27,40-41H,4-7,15-17H2,(H,42,43)/t26-,27-/m0/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
Plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with PBS containing 2% BSA...


US Patent US10639284 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM440850
PNG
(US10639284, Compound 3.019)
Show SMILES O[C@H]1CCC[C@@H]1NCc1cc(Cl)c(O[C@H]2CCc3c2cccc3-c2ccccc2F)cc1OCc1cncc(c1)C#N
Show InChI InChI=1S/C34H31ClFN3O3/c35-28-14-23(19-39-30-9-4-10-31(30)40)33(41-20-22-13-21(16-37)17-38-18-22)15-34(28)42-32-12-11-25-24(6-3-7-27(25)32)26-5-1-2-8-29(26)36/h1-3,5-8,13-15,17-18,30-32,39-40H,4,9-12,19-20H2/t30-,31-,32-/m0/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
Plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with PBS containing 2% BSA...


US Patent US10639284 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM440868
PNG
(US10639284, Compound 3.037)
Show SMILES O[C@@H]1COCC[C@H]1NCc1cc(Cl)c(O[C@H]2CCc3c2cccc3-c2ccccc2F)cc1OCc1cncc(c1)C#N
Show InChI InChI=1S/C34H31ClFN3O4/c35-28-13-23(18-39-30-10-11-41-20-31(30)40)33(42-19-22-12-21(15-37)16-38-17-22)14-34(28)43-32-9-8-25-24(5-3-6-27(25)32)26-4-1-2-7-29(26)36/h1-7,12-14,16-17,30-32,39-40H,8-11,18-20H2/t30-,31-,32+/m1/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
Plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with PBS containing 2% BSA...


US Patent US10639284 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM440869
PNG
(US10639284, Compound 3.038 | US10639284, Compound ...)
Show SMILES O[C@@H]1CCCC[C@H]1NCc1cc(Cl)c(O[C@H]2CCc3c2cccc3-c2ccccc2F)cc1OCc1cncc(c1)C#N
Show InChI InChI=1S/C35H33ClFN3O3/c36-29-15-24(20-40-31-10-3-4-11-32(31)41)34(42-21-23-14-22(17-38)18-39-19-23)16-35(29)43-33-13-12-26-25(7-5-8-28(26)33)27-6-1-2-9-30(27)37/h1-2,5-9,14-16,18-19,31-33,40-41H,3-4,10-13,20-21H2/t31-,32-,33+/m1/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
Plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with PBS containing 2% BSA...


US Patent US10639284 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM440884
PNG
(US10639284, Compound 3.053)
Show SMILES C[C@@H](O)[C@H](NCc1cc(Cl)c(O[C@H]2CCc3c2cccc3-c2ccc3OCCOc3c2F)cc1OCc1cncc(c1)C#N)C(O)=O
Show InChI InChI=1S/C35H31ClFN3O7/c1-19(41)33(35(42)43)40-17-22-12-27(36)31(13-30(22)46-18-21-11-20(14-38)15-39-16-21)47-28-7-5-24-23(3-2-4-25(24)28)26-6-8-29-34(32(26)37)45-10-9-44-29/h2-4,6,8,11-13,15-16,19,28,33,40-41H,5,7,9-10,17-18H2,1H3,(H,42,43)/t19-,28+,33+/m1/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
Plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with PBS containing 2% BSA...


US Patent US10639284 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM440888
PNG
(US10639284, Compound 3.057)
Show SMILES OCC(CO)(CO)NCc1cc(Cl)c(O[C@H]2CCc3c2cccc3-c2ccc3OCCOc3c2F)cc1OCc1cncc(c1)C#N
Show InChI InChI=1S/C35H33ClFN3O7/c36-28-11-23(16-40-35(18-41,19-42)20-43)31(46-17-22-10-21(13-38)14-39-15-22)12-32(28)47-29-6-4-25-24(2-1-3-26(25)29)27-5-7-30-34(33(27)37)45-9-8-44-30/h1-3,5,7,10-12,14-15,29,40-43H,4,6,8-9,16-20H2/t29-/m0/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
Plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with PBS containing 2% BSA...


US Patent US10639284 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM440890
PNG
(US10639284, Compound 3.059)
Show SMILES Fc1ccccc1-c1cccc2[C@H](CCc12)Oc1cc(OCc2cncc(c2)C#N)c(CNCc2c[nH]cn2)cc1Cl
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ChemoCentryx, Inc.

US Patent


Assay Description
Plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with PBS containing 2% BSA...


US Patent US10639284 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM440869
PNG
(US10639284, Compound 3.038 | US10639284, Compound ...)
Show SMILES O[C@@H]1CCCC[C@H]1NCc1cc(Cl)c(O[C@H]2CCc3c2cccc3-c2ccccc2F)cc1OCc1cncc(c1)C#N
Show InChI InChI=1S/C35H33ClFN3O3/c36-29-15-24(20-40-31-10-3-4-11-32(31)41)34(42-21-23-14-22(17-38)18-39-19-23)16-35(29)43-33-13-12-26-25(7-5-8-28(26)33)27-6-1-2-9-30(27)37/h1-2,5-9,14-16,18-19,31-33,40-41H,3-4,10-13,20-21H2/t31-,32-,33+/m1/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
Plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with PBS containing 2% BSA...


US Patent US10639284 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM440917
PNG
(US10639284, Compound 3.086)
Show SMILES C[C@H](NCc1cc(Cl)c(O[C@H]2CCc3c2cccc3-c2ccccc2F)cc1OCc1cncc(c1)C#N)C(=O)N[C@@H](C)P(O)(O)=O
Show InChI InChI=1S/C34H33ClFN4O6P/c1-20(34(41)40-21(2)47(42,43)44)39-18-24-13-29(35)33(14-32(24)45-19-23-12-22(15-37)16-38-17-23)46-31-11-10-26-25(7-5-8-28(26)31)27-6-3-4-9-30(27)36/h3-9,12-14,16-17,20-21,31,39H,10-11,18-19H2,1-2H3,(H,40,41)(H2,42,43,44)/t20-,21+,31-/m0/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
Plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with PBS containing 2% BSA...


US Patent US10639284 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM440935
PNG
(US10639284, Compound 3.104)
Show SMILES NC(=O)C[C@@H](NCc1cc(Cl)c(O[C@H]2CCc3c2cccc3-c2ccccc2F)cc1OCc1cncc(c1)C#N)C(O)=O
Show InChI InChI=1S/C33H28ClFN4O5/c34-26-11-21(17-39-28(33(41)42)12-32(37)40)30(43-18-20-10-19(14-36)15-38-16-20)13-31(26)44-29-9-8-23-22(5-3-6-25(23)29)24-4-1-2-7-27(24)35/h1-7,10-11,13,15-16,28-29,39H,8-9,12,17-18H2,(H2,37,40)(H,41,42)/t28-,29+/m1/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
Plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with PBS containing 2% BSA...


US Patent US10639284 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM440950
PNG
(US10639284, Compound 3.119)
Show SMILES C[C@@](CO)(NCc1cc(Cl)c(O[C@@H]2CCc3c2cccc3-c2ccccc2F)cc1OCc1cncc(c1)C#N)C(O)=O
Show InChI InChI=1S/C33H29ClFN3O5/c1-33(19-39,32(40)41)38-17-22-12-27(34)31(13-30(22)42-18-21-11-20(14-36)15-37-16-21)43-29-10-9-24-23(6-4-7-26(24)29)25-5-2-3-8-28(25)35/h2-8,11-13,15-16,29,38-39H,9-10,17-19H2,1H3,(H,40,41)/t29-,33+/m1/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
Plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with PBS containing 2% BSA...


US Patent US10639284 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM440960
PNG
(US10639284, Compound 3.129)
Show SMILES OCC(CO)NCc1cc(Cl)c(O[C@H]2CCc3c2cccc3-c2ccccc2F)cc1OCc1cncc(c1)C#N
Show InChI InChI=1S/C32H29ClFN3O4/c33-28-11-22(16-37-23(17-38)18-39)31(40-19-21-10-20(13-35)14-36-15-21)12-32(28)41-30-9-8-25-24(5-3-6-27(25)30)26-4-1-2-7-29(26)34/h1-7,10-12,14-15,23,30,37-39H,8-9,16-19H2/t30-/m0/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
Plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with PBS containing 2% BSA...


US Patent US10639284 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM440652
PNG
(US10639284, Compound 2.004 | US10639284, Compound ...)
Show SMILES OC[C@H](NCc1cc(Cl)c(O[C@H]2CCc3c2cccc3-c2ccccc2F)cc1OCc1cncc(c1)C#N)C(O)=O
Show InChI InChI=1S/C32H27ClFN3O5/c33-26-11-21(16-37-28(17-38)32(39)40)30(41-18-20-10-19(13-35)14-36-15-20)12-31(26)42-29-9-8-23-22(5-3-6-25(23)29)24-4-1-2-7-27(24)34/h1-7,10-12,14-15,28-29,37-38H,8-9,16-18H2,(H,39,40)/t28-,29-/m0/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
Plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with PBS containing 2% BSA...


US Patent US10639284 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM440677
PNG
(US10639284, Compound 2.028)
Show SMILES COc1cccc(c1F)-c1cccc2[C@H](CCc12)Oc1cc(OCc2cncc(c2)C#N)c(CN[C@@H](CO)C(O)=O)cc1Cl
Show InChI InChI=1S/C33H29ClFN3O6/c1-42-29-7-3-6-25(32(29)35)22-4-2-5-24-23(22)8-9-28(24)44-31-12-30(43-18-20-10-19(13-36)14-37-15-20)21(11-26(31)34)16-38-27(17-39)33(40)41/h2-7,10-12,14-15,27-28,38-39H,8-9,16-18H2,1H3,(H,40,41)/t27-,28-/m0/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
Plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with PBS containing 2% BSA...


US Patent US10639284 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM440688
PNG
(US10639284, Compound 2.039)
Show SMILES COc1cc(O[C@H]2CCc3c2cccc3-c2ccc3OCCOc3c2)c(Cl)cc1CN[C@@H](CO)C(O)=O
Show InChI InChI=1S/C28H28ClNO7/c1-34-25-13-26(21(29)11-17(25)14-30-22(15-31)28(32)33)37-23-8-6-19-18(3-2-4-20(19)23)16-5-7-24-27(12-16)36-10-9-35-24/h2-5,7,11-13,22-23,30-31H,6,8-10,14-15H2,1H3,(H,32,33)/t22-,23-/m0/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
Plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with PBS containing 2% BSA...


US Patent US10639284 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM440699
PNG
(US10639284, Compound 2.050)
Show SMILES OC1CN(Cc2cc(Cl)c(O[C@H]3CCc4c3cccc4-c3ccc4OCCOc4c3)cc2OCc2cncc(c2)C#N)C1
Show InChI InChI=1S/C34H30ClN3O5/c35-29-11-24(17-38-18-25(39)19-38)32(42-20-22-10-21(14-36)15-37-16-22)13-33(29)43-30-7-5-27-26(2-1-3-28(27)30)23-4-6-31-34(12-23)41-9-8-40-31/h1-4,6,10-13,15-16,25,30,39H,5,7-9,17-20H2/t30-/m0/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
Plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with PBS containing 2% BSA...


US Patent US10639284 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM440700
PNG
(US10639284, Compound 2.051)
Show SMILES COc1cccc(c1F)-c1cccc2[C@H](CCc12)Oc1cc(OCc2cncc(c2)C#N)c(CN2CC(O)C2)cc1Cl
Show InChI InChI=1S/C33H29ClFN3O4/c1-40-30-7-3-6-27(33(30)35)24-4-2-5-26-25(24)8-9-29(26)42-32-12-31(41-19-21-10-20(13-36)14-37-15-21)22(11-28(32)34)16-38-17-23(39)18-38/h2-7,10-12,14-15,23,29,39H,8-9,16-19H2,1H3/t29-/m0/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
Plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with PBS containing 2% BSA...


US Patent US10639284 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM440707
PNG
(US10639284, Compound 2.058)
Show SMILES OC1CCN(Cc2cc(Cl)c(O[C@H]3CCc4c3cccc4-c3ccc4OCCOc4c3F)cc2OCc2cncc(c2)C#N)CC1
Show InChI InChI=1S/C36H33ClFN3O5/c37-30-15-24(20-41-10-8-25(42)9-11-41)33(45-21-23-14-22(17-39)18-40-19-23)16-34(30)46-31-6-4-27-26(2-1-3-28(27)31)29-5-7-32-36(35(29)38)44-13-12-43-32/h1-3,5,7,14-16,18-19,25,31,42H,4,6,8-13,20-21H2/t31-/m0/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
Plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with PBS containing 2% BSA...


US Patent US10639284 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM440782
PNG
(US10639284, Compound 2.129)
Show SMILES C[C@@H](O)[C@@H](NCc1cc(Cl)c(O[C@H]2CCc3c2cccc3-c2ccccc2F)cc1OCc1cncc(c1)C#N)C(O)=O
Show InChI InChI=1S/C33H29ClFN3O5/c1-19(39)32(33(40)41)38-17-22-12-27(34)31(13-30(22)42-18-21-11-20(14-36)15-37-16-21)43-29-10-9-24-23(6-4-7-26(24)29)25-5-2-3-8-28(25)35/h2-8,11-13,15-16,19,29,32,38-39H,9-10,17-18H2,1H3,(H,40,41)/t19-,29+,32-/m1/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
Plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with PBS containing 2% BSA...


US Patent US10639284 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM440805
PNG
(US10639284, Compound 2.152)
Show SMILES CC(CO)(NCc1cc(Cl)c(O[C@H]2CCc3c2cccc3-c2ccccc2F)cc1OCc1cncc(c1)C#N)C(O)=O
Show InChI InChI=1S/C33H29ClFN3O5/c1-33(19-39,32(40)41)38-17-22-12-27(34)31(13-30(22)42-18-21-11-20(14-36)15-37-16-21)43-29-10-9-24-23(6-4-7-26(24)29)25-5-2-3-8-28(25)35/h2-8,11-13,15-16,29,38-39H,9-10,17-19H2,1H3,(H,40,41)/t29-,33?/m0/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
Plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with PBS containing 2% BSA...


US Patent US10639284 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM440840
PNG
(US10639284, Compound 3.009)
Show SMILES C[C@@](CO)(NCc1cc(Cl)c(O[C@H]2CCc3c2cccc3-c2ccc3OCCOc3c2F)cc1OCc1cncc(c1)C#N)C(O)=O
Show InChI InChI=1S/C35H31ClFN3O7/c1-35(19-41,34(42)43)40-17-22-12-27(36)31(13-30(22)46-18-21-11-20(14-38)15-39-16-21)47-28-7-5-24-23(3-2-4-25(24)28)26-6-8-29-33(32(26)37)45-10-9-44-29/h2-4,6,8,11-13,15-16,28,40-41H,5,7,9-10,17-19H2,1H3,(H,42,43)/t28-,35-/m0/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
Plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with PBS containing 2% BSA...


US Patent US10639284 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM440847
PNG
(US10639284, Compound 3.016)
Show SMILES COc1cccc(c1Cl)-c1cccc2[C@H](CCc12)Oc1cc(OCc2cc(cc(c2)C#N)C#N)c(CN[C@@H](CO)C(O)=O)cc1Cl
Show InChI InChI=1S/C35H29Cl2N3O6/c1-44-31-7-3-6-27(34(31)37)24-4-2-5-26-25(24)8-9-30(26)46-33-14-32(23(13-28(33)36)17-40-29(18-41)35(42)43)45-19-22-11-20(15-38)10-21(12-22)16-39/h2-7,10-14,29-30,40-41H,8-9,17-19H2,1H3,(H,42,43)/t29-,30-/m0/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
Plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with PBS containing 2% BSA...


US Patent US10639284 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM440878
PNG
(US10639284, Compound 3.047)
Show SMILES C[C@H](NCc1cc(Cl)c(O[C@H]2CCc3c2cccc3-c2ccccc2F)cc1OCc1cncc(c1)C#N)C(=O)N[C@@H](CO)C(O)=O
Show InChI InChI=1S/C35H32ClFN4O6/c1-20(34(43)41-30(18-42)35(44)45)40-17-23-12-28(36)33(13-32(23)46-19-22-11-21(14-38)15-39-16-22)47-31-10-9-25-24(6-4-7-27(25)31)26-5-2-3-8-29(26)37/h2-8,11-13,15-16,20,30-31,40,42H,9-10,17-19H2,1H3,(H,41,43)(H,44,45)/t20-,30-,31-/m0/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
Plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with PBS containing 2% BSA...


US Patent US10639284 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM440879
PNG
(US10639284, Compound 3.048)
Show SMILES OC[C@H](NCc1cc(Cl)c(O[C@H]2CCc3c2cccc3-c2ccccc2F)cc1OCc1cncc(c1)C#N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(O)=O
Show InChI InChI=1S/C38H37ClFN5O9/c39-28-11-23(16-43-30(17-46)36(49)44-31(18-47)37(50)45-32(19-48)38(51)52)34(53-20-22-10-21(13-41)14-42-15-22)12-35(28)54-33-9-8-25-24(5-3-6-27(25)33)26-4-1-2-7-29(26)40/h1-7,10-12,14-15,30-33,43,46-48H,8-9,16-20H2,(H,44,49)(H,45,50)(H,51,52)/t30-,31-,32-,33-/m0/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
Plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with PBS containing 2% BSA...


US Patent US10639284 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM440636
PNG
(US10639284, Compound 1.004)
Show SMILES OCCNCc1cc(Cl)c(OC2CCc3c2cccc3-c2ccccc2)cc1OCc1cncc(c1)C#N
Show InChI InChI=1S/C31H28ClN3O3/c32-28-14-24(19-34-11-12-36)30(37-20-22-13-21(16-33)17-35-18-22)15-31(28)38-29-10-9-26-25(7-4-8-27(26)29)23-5-2-1-3-6-23/h1-8,13-15,17-18,29,34,36H,9-12,19-20H2
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ChemoCentryx, Inc.

US Patent


Assay Description
Plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with PBS containing 2% BSA...


US Patent US10639284 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM440900
PNG
(US10639284, Compound 3.069)
Show SMILES OC[C@@H](NCc1cc(Cl)c(O[C@@H]2CCc3c2cccc3-c2ccccc2F)cc1OCc1cncc(c1)C#N)C(O)=O
Show InChI InChI=1S/C32H27ClFN3O5/c33-26-11-21(16-37-28(17-38)32(39)40)30(41-18-20-10-19(13-35)14-36-15-20)12-31(26)42-29-9-8-23-22(5-3-6-25(23)29)24-4-1-2-7-27(24)34/h1-7,10-12,14-15,28-29,37-38H,8-9,16-18H2,(H,39,40)/t28-,29-/m1/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
Plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with PBS containing 2% BSA...


US Patent US10639284 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM440925
PNG
(US10639284, Compound 3.094)
Show SMILES OC(=O)C(Cc1cccnc1)NCc1cc(Cl)c(O[C@H]2CCc3c2cccc3-c2ccccc2F)cc1OCc1cncc(c1)C#N
Show InChI InChI=1S/C37H30ClFN4O4/c38-31-15-26(21-43-33(37(44)45)14-23-5-4-12-41-18-23)35(46-22-25-13-24(17-40)19-42-20-25)16-36(31)47-34-11-10-28-27(7-3-8-30(28)34)29-6-1-2-9-32(29)39/h1-9,12-13,15-16,18-20,33-34,43H,10-11,14,21-22H2,(H,44,45)/t33?,34-/m0/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
Plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with PBS containing 2% BSA...


US Patent US10639284 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM440653
PNG
(US10639284, Compound 2.005)
Show SMILES OC[C@H](NCc1cc(Cl)c(O[C@H]2CCc3c2cccc3-c2ccccc2Cl)cc1OCc1cncc(c1)C#N)C(O)=O
Show InChI InChI=1S/C32H27Cl2N3O5/c33-26-7-2-1-4-24(26)22-5-3-6-25-23(22)8-9-29(25)42-31-12-30(41-18-20-10-19(13-35)14-36-15-20)21(11-27(31)34)16-37-28(17-38)32(39)40/h1-7,10-12,14-15,28-29,37-38H,8-9,16-18H2,(H,39,40)/t28-,29-/m0/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
Plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with PBS containing 2% BSA...


US Patent US10639284 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM440664
PNG
(US10639284, Compound 2.015)
Show SMILES COc1cccc(c1)-c1cccc2[C@H](CCc12)Oc1cc(OCc2cncc(c2)C#N)c(CN[C@@H](CO)C(O)=O)cc1Cl
Show InChI InChI=1S/C33H30ClN3O6/c1-41-24-5-2-4-22(11-24)25-6-3-7-27-26(25)8-9-30(27)43-32-13-31(42-19-21-10-20(14-35)15-36-16-21)23(12-28(32)34)17-37-29(18-38)33(39)40/h2-7,10-13,15-16,29-30,37-38H,8-9,17-19H2,1H3,(H,39,40)/t29-,30-/m0/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
Plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with PBS containing 2% BSA...


US Patent US10639284 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM440706
PNG
(US10639284, Compound 2.057 | US10639284, Compound ...)
Show SMILES OC[C@H](NCc1cc(Cl)c(O[C@H]2CCc3c2cccc3-c2ccc3OCCOc3c2F)cc1OCc1cncc(c1)C#N)C(O)=O
Show InChI InChI=1S/C34H29ClFN3O7/c35-26-11-21(16-39-27(17-40)34(41)42)30(45-18-20-10-19(13-37)14-38-15-20)12-31(26)46-28-6-4-23-22(2-1-3-24(23)28)25-5-7-29-33(32(25)36)44-9-8-43-29/h1-3,5,7,10-12,14-15,27-28,39-40H,4,6,8-9,16-18H2,(H,41,42)/t27-,28-/m0/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
Plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with PBS containing 2% BSA...


US Patent US10639284 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM440753
PNG
(US10639284, Compound 2.100 | US10639284, Compound ...)
Show SMILES C[C@@H](O)[C@H](NCc1cc(Cl)c(O[C@H]2CCc3c2cccc3-c2ccccc2F)cc1OCc1cncc(c1)C#N)C(O)=O
Show InChI InChI=1S/C33H29ClFN3O5/c1-19(39)32(33(40)41)38-17-22-12-27(34)31(13-30(22)42-18-21-11-20(14-36)15-37-16-21)43-29-10-9-24-23(6-4-7-26(24)29)25-5-2-3-8-28(25)35/h2-8,11-13,15-16,19,29,32,38-39H,9-10,17-18H2,1H3,(H,40,41)/t19-,29+,32+/m1/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
Plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with PBS containing 2% BSA...


US Patent US10639284 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM440755
PNG
(US10639284, Compound 2.102 | US10639284, Compound ...)
Show SMILES OC[C@@H](NCc1cc(Cl)c(O[C@H]2CCc3c2cccc3-c2ccccc2F)cc1OCc1cncc(c1)C#N)C(O)=O
Show InChI InChI=1S/C32H27ClFN3O5/c33-26-11-21(16-37-28(17-38)32(39)40)30(41-18-20-10-19(13-35)14-36-15-20)12-31(26)42-29-9-8-23-22(5-3-6-25(23)29)24-4-1-2-7-27(24)34/h1-7,10-12,14-15,28-29,37-38H,8-9,16-18H2,(H,39,40)/t28-,29+/m1/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
Plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with PBS containing 2% BSA...


US Patent US10639284 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM440768
PNG
(US10639284, Compound 2.115)
Show SMILES OC[C@H](NCc1cc(Cl)c(O[C@H]2CCc3c2cccc3-c2ccccc2F)cc1-c1cncc(c1)C#N)C(O)=O
Show InChI InChI=1S/C31H25ClFN3O4/c32-26-11-20(16-36-28(17-37)31(38)39)25(19-10-18(13-34)14-35-15-19)12-30(26)40-29-9-8-22-21(5-3-6-24(22)29)23-4-1-2-7-27(23)33/h1-7,10-12,14-15,28-29,36-37H,8-9,16-17H2,(H,38,39)/t28-,29-/m0/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
Plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with PBS containing 2% BSA...


US Patent US10639284 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM440780
PNG
(US10639284, Compound 2.127 | US10639284, Compound ...)
Show SMILES C[C@H](O)[C@H](NCc1cc(Cl)c(O[C@H]2CCc3c2cccc3-c2ccccc2F)cc1OCc1cncc(c1)C#N)C(O)=O
Show InChI InChI=1S/C33H29ClFN3O5/c1-19(39)32(33(40)41)38-17-22-12-27(34)31(13-30(22)42-18-21-11-20(14-36)15-37-16-21)43-29-10-9-24-23(6-4-7-26(24)29)25-5-2-3-8-28(25)35/h2-8,11-13,15-16,19,29,32,38-39H,9-10,17-18H2,1H3,(H,40,41)/t19-,29-,32-/m0/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
Plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with PBS containing 2% BSA...


US Patent US10639284 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM440792
PNG
(US10639284, Compound 2.139 | US10639284, Compound ...)
Show SMILES OC[C@H](NCc1cc(Cl)c(O[C@@H]2CCc3c2cccc3-c2ccccc2F)cc1OCc1cncc(c1)C#N)C(O)=O
Show InChI InChI=1S/C32H27ClFN3O5/c33-26-11-21(16-37-28(17-38)32(39)40)30(41-18-20-10-19(13-35)14-36-15-20)12-31(26)42-29-9-8-23-22(5-3-6-25(23)29)24-4-1-2-7-27(24)34/h1-7,10-12,14-15,28-29,37-38H,8-9,16-18H2,(H,39,40)/t28-,29+/m0/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
Plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with PBS containing 2% BSA...


US Patent US10639284 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM440797
PNG
(US10639284, Compound 2.144)
Show SMILES OC(=O)C1(CC1)NCc1cc(Cl)c(O[C@H]2CCc3c2cccc3-c2ccccc2F)cc1OCc1cncc(c1)C#N
Show InChI InChI=1S/C33H27ClFN3O4/c34-27-13-22(18-38-33(10-11-33)32(39)40)30(41-19-21-12-20(15-36)16-37-17-21)14-31(27)42-29-9-8-24-23(5-3-6-26(24)29)25-4-1-2-7-28(25)35/h1-7,12-14,16-17,29,38H,8-11,18-19H2,(H,39,40)/t29-/m0/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
Plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with PBS containing 2% BSA...


US Patent US10639284 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%