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Patent code US10640495

Compile Data Set for Download or QSAR

Found 646 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM441096
PNG
(US10640495, Example I-258)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2cnc3n(C)c(=O)[nH]c3c2)[C@@H](O1)c1cnc(F)c(F)c1
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n/an/a 0.480n/an/an/an/an/an/a



Shionogi & Co., Ltd.

US Patent


Assay Description
Seven point five μL per well of human TrkA (PV3144, Lifetechnologies, final concentration: 1 nmol/L) suspended in the assay buffer (100 mmol/L 4...


US Patent US10640495 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM441060
PNG
(US10640495, Example I-31 | US10640495, Example I-3...)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)C2=CCN(CC2)C(C)=O)[C@@H](O1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C30H34F2N6O4/c1-19-27(21-11-13-36(14-12-21)20(2)39)35-38(23-7-5-4-6-8-23)29(19)34-30(40)33-26-18-37(15-16-41-3)42-28(26)22-9-10-24(31)25(32)17-22/h4-11,17,26,28H,12-16,18H2,1-3H3,(H2,33,34,40)/t26-,28+/m1/s1
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n/an/a 0.480n/an/an/an/an/an/a



Shionogi & Co., Ltd.

US Patent


Assay Description
Seven point five μL per well of human TrkA (PV3144, Lifetechnologies, final concentration: 1 nmol/L) suspended in the assay buffer (100 mmol/L 4...


US Patent US10640495 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM441123
PNG
(US10640495, Example I-458)
Show SMILES CNC(=O)c1ccc(cn1)-c1nn(c(NC(=O)N[C@@H]2CN(CCOC)O[C@H]2c2ccc(F)c(F)c2)c1C)-c1ccccc1
Show InChI InChI=1S/C30H31F2N7O4/c1-18-26(20-10-12-24(34-16-20)29(40)33-2)37-39(21-7-5-4-6-8-21)28(18)36-30(41)35-25-17-38(13-14-42-3)43-27(25)19-9-11-22(31)23(32)15-19/h4-12,15-16,25,27H,13-14,17H2,1-3H3,(H,33,40)(H2,35,36,41)/t25-,27+/m1/s1
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n/an/a 0.520n/an/an/an/an/an/a



Shionogi & Co., Ltd.

US Patent


Assay Description
Seven point five μL per well of human TrkA (PV3144, Lifetechnologies, final concentration: 1 nmol/L) suspended in the assay buffer (100 mmol/L 4...


US Patent US10640495 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM441075
PNG
(US10640495, Example I-135)
Show SMILES CNc1ncc(cn1)-c1nn(c(NC(=O)N[C@@H]2CN(CCOC)O[C@H]2c2cnc(F)c(F)c2)c1C)-c1ccccc1
Show InChI InChI=1S/C27H29F2N9O3/c1-16-22(18-13-32-26(30-2)33-14-18)36-38(19-7-5-4-6-8-19)25(16)35-27(39)34-21-15-37(9-10-40-3)41-23(21)17-11-20(28)24(29)31-12-17/h4-8,11-14,21,23H,9-10,15H2,1-3H3,(H,30,32,33)(H2,34,35,39)/t21-,23+/m1/s1
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n/an/a 0.520n/an/an/an/an/an/a



Shionogi & Co., Ltd.

US Patent


Assay Description
Seven point five μL per well of human TrkA (PV3144, Lifetechnologies, final concentration: 1 nmol/L) suspended in the assay buffer (100 mmol/L 4...


US Patent US10640495 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM441133
PNG
(US10640495, Example I-639)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2cnc(OC)c(CN(C)C)c2)[C@@H](O1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C32H37F2N7O4/c1-20-28(22-15-23(18-39(2)3)31(44-5)35-17-22)38-41(24-9-7-6-8-10-24)30(20)37-32(42)36-27-19-40(13-14-43-4)45-29(27)21-11-12-25(33)26(34)16-21/h6-12,15-17,27,29H,13-14,18-19H2,1-5H3,(H2,36,37,42)/t27-,29+/m1/s1
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Shionogi & Co., Ltd.

US Patent


Assay Description
Seven point five μL per well of human TrkA (PV3144, Lifetechnologies, final concentration: 1 nmol/L) suspended in the assay buffer (100 mmol/L 4...


US Patent US10640495 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM441097
PNG
(US10640495, Example I-268)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2cnc(N=S(C)(C)=O)nc2)[C@@H](O1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C29H32F2N8O4S/c1-18-25(20-15-32-28(33-16-20)37-44(3,4)41)36-39(21-8-6-5-7-9-21)27(18)35-29(40)34-24-17-38(12-13-42-2)43-26(24)19-10-11-22(30)23(31)14-19/h5-11,14-16,24,26H,12-13,17H2,1-4H3,(H2,34,35,40)/t24-,26+/m1/s1
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n/an/a 0.550n/an/an/an/an/an/a



Shionogi & Co., Ltd.

US Patent


Assay Description
Seven point five μL per well of human TrkA (PV3144, Lifetechnologies, final concentration: 1 nmol/L) suspended in the assay buffer (100 mmol/L 4...


US Patent US10640495 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM441104
PNG
(US10640495, Example I-298)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2cnc3n(C)nc(N=S(C)(C)=O)c3c2)[C@@H](O1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C32H35F2N9O4S/c1-19-27(21-15-23-29(40-48(4,5)45)39-41(2)31(23)35-17-21)38-43(22-9-7-6-8-10-22)30(19)37-32(44)36-26-18-42(13-14-46-3)47-28(26)20-11-12-24(33)25(34)16-20/h6-12,15-17,26,28H,13-14,18H2,1-5H3,(H2,36,37,44)/t26-,28+/m1/s1
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n/an/a 0.600n/an/an/an/an/an/a



Shionogi & Co., Ltd.

US Patent


Assay Description
Seven point five μL per well of human TrkA (PV3144, Lifetechnologies, final concentration: 1 nmol/L) suspended in the assay buffer (100 mmol/L 4...


US Patent US10640495 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM441110
PNG
(US10640495, Example I-315)
Show SMILES CNC(=O)c1ncc(cc1NC)-c1nn(c(NC(=O)N[C@@H]2CN(CCOC)O[C@H]2c2ccc(F)c(F)c2)c1C)-c1ccccc1
Show InChI InChI=1S/C31H34F2N8O4/c1-18-26(20-15-24(34-2)27(36-16-20)30(42)35-3)39-41(21-8-6-5-7-9-21)29(18)38-31(43)37-25-17-40(12-13-44-4)45-28(25)19-10-11-22(32)23(33)14-19/h5-11,14-16,25,28,34H,12-13,17H2,1-4H3,(H,35,42)(H2,37,38,43)/t25-,28+/m1/s1
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Shionogi & Co., Ltd.

US Patent


Assay Description
Seven point five μL per well of human TrkA (PV3144, Lifetechnologies, final concentration: 1 nmol/L) suspended in the assay buffer (100 mmol/L 4...


US Patent US10640495 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM441060
PNG
(US10640495, Example I-31 | US10640495, Example I-3...)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)C2=CCN(CC2)C(C)=O)[C@@H](O1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C30H34F2N6O4/c1-19-27(21-11-13-36(14-12-21)20(2)39)35-38(23-7-5-4-6-8-23)29(19)34-30(40)33-26-18-37(15-16-41-3)42-28(26)22-9-10-24(31)25(32)17-22/h4-11,17,26,28H,12-16,18H2,1-3H3,(H2,33,34,40)/t26-,28+/m1/s1
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Shionogi & Co., Ltd.

US Patent


Assay Description
Seven point five μL per well of human TrkA (PV3144, Lifetechnologies, final concentration: 1 nmol/L) suspended in the assay buffer (100 mmol/L 4...


US Patent US10640495 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM441057
PNG
(US10640495, Example I-22)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2ccc3n(C)ncc3c2)[C@@H](O1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C31H31F2N7O3/c1-19-28(20-10-12-27-22(15-20)17-34-38(27)2)37-40(23-7-5-4-6-8-23)30(19)36-31(41)35-26-18-39(13-14-42-3)43-29(26)21-9-11-24(32)25(33)16-21/h4-12,15-17,26,29H,13-14,18H2,1-3H3,(H2,35,36,41)/t26-,29+/m1/s1
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Shionogi & Co., Ltd.

US Patent


Assay Description
Seven point five μL per well of human TrkA (PV3144, Lifetechnologies, final concentration: 1 nmol/L) suspended in the assay buffer (100 mmol/L 4...


US Patent US10640495 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM441077
PNG
(US10640495, Example I-145)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2ccc(nc2)-c2nn[nH]n2)[C@@H](O1)c1ccc(F)c(F)c1
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Shionogi & Co., Ltd.

US Patent


Assay Description
Seven point five μL per well of human TrkA (PV3144, Lifetechnologies, final concentration: 1 nmol/L) suspended in the assay buffer (100 mmol/L 4...


US Patent US10640495 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM441063
PNG
(US10640495, Example I-40 | US10640495, Example I-6...)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2cnc3n(C)ncc3c2)[C@@H](O1)c1ccnc(F)c1
Show InChI InChI=1S/C29H30FN9O3/c1-18-25(20-13-21-16-33-37(2)28(21)32-15-20)36-39(22-7-5-4-6-8-22)27(18)35-29(40)34-23-17-38(11-12-41-3)42-26(23)19-9-10-31-24(30)14-19/h4-10,13-16,23,26H,11-12,17H2,1-3H3,(H2,34,35,40)/t23-,26+/m1/s1
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Shionogi & Co., Ltd.

US Patent


Assay Description
Seven point five μL per well of human TrkA (PV3144, Lifetechnologies, final concentration: 1 nmol/L) suspended in the assay buffer (100 mmol/L 4...


US Patent US10640495 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM441129
PNG
(US10640495, Example I-489 | US10640495, Example I-...)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2cnc(nc2)N2CC(C2)OC)[C@@H](O1)c1ccnc(F)c1
Show InChI InChI=1S/C30H34FN9O4/c1-19-26(21-14-33-29(34-15-21)38-16-23(17-38)43-3)37-40(22-7-5-4-6-8-22)28(19)36-30(41)35-24-18-39(11-12-42-2)44-27(24)20-9-10-32-25(31)13-20/h4-10,13-15,23-24,27H,11-12,16-18H2,1-3H3,(H2,35,36,41)/t24-,27+/m1/s1
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Shionogi & Co., Ltd.

US Patent


Assay Description
Seven point five μL per well of human TrkA (PV3144, Lifetechnologies, final concentration: 1 nmol/L) suspended in the assay buffer (100 mmol/L 4...


US Patent US10640495 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM441116
PNG
(US10640495, Example I-344)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)N2CCN(C)C(=O)C2)[C@@H](O1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C28H33F2N7O4/c1-18-26(37(20-7-5-4-6-8-20)33-27(18)35-12-11-34(2)24(38)17-35)32-28(39)31-23-16-36(13-14-40-3)41-25(23)19-9-10-21(29)22(30)15-19/h4-10,15,23,25H,11-14,16-17H2,1-3H3,(H2,31,32,39)/t23-,25+/m1/s1
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Shionogi & Co., Ltd.

US Patent


Assay Description
Seven point five μL per well of human TrkA (PV3144, Lifetechnologies, final concentration: 1 nmol/L) suspended in the assay buffer (100 mmol/L 4...


US Patent US10640495 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM441072
PNG
(US10640495, Example I-108)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2cc(C(=O)NC3CCOCC3)c(=O)n(C)c2)[C@@H](O1)c1ccnc(F)c1
Show InChI InChI=1S/C34H39FN8O6/c1-21-29(23-17-26(33(45)41(2)19-23)32(44)37-24-10-14-48-15-11-24)40-43(25-7-5-4-6-8-25)31(21)39-34(46)38-27-20-42(13-16-47-3)49-30(27)22-9-12-36-28(35)18-22/h4-9,12,17-19,24,27,30H,10-11,13-16,20H2,1-3H3,(H,37,44)(H2,38,39,46)/t27-,30+/m1/s1
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n/an/a 1n/an/an/an/an/an/a



Shionogi & Co., Ltd.

US Patent


Assay Description
Seven point five μL per well of human TrkA (PV3144, Lifetechnologies, final concentration: 1 nmol/L) suspended in the assay buffer (100 mmol/L 4...


US Patent US10640495 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM441124
PNG
(US10640495, Example I-508)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2cnc(COC)nc2)[C@@H](O1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C29H31F2N7O4/c1-18-26(20-14-32-25(17-41-3)33-15-20)36-38(21-7-5-4-6-8-21)28(18)35-29(39)34-24-16-37(11-12-40-2)42-27(24)19-9-10-22(30)23(31)13-19/h4-10,13-15,24,27H,11-12,16-17H2,1-3H3,(H2,34,35,39)/t24-,27+/m1/s1
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n/an/a 1.10n/an/an/an/an/an/a



Shionogi & Co., Ltd.

US Patent


Assay Description
Seven point five μL per well of human TrkA (PV3144, Lifetechnologies, final concentration: 1 nmol/L) suspended in the assay buffer (100 mmol/L 4...


US Patent US10640495 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM441111
PNG
(US10640495, Example I-319)
Show SMILES CNC(=O)c1cc(cnc1OC)-c1nn(c(NC(=O)N[C@@H]2C[C@@H](CCOC)O[C@H]2c2ccnc(F)c2)c1C)-c1ccccc1
Show InChI InChI=1S/C31H34FN7O5/c1-18-26(20-14-23(29(40)33-2)30(43-4)35-17-20)38-39(21-8-6-5-7-9-21)28(18)37-31(41)36-24-16-22(11-13-42-3)44-27(24)19-10-12-34-25(32)15-19/h5-10,12,14-15,17,22,24,27H,11,13,16H2,1-4H3,(H,33,40)(H2,36,37,41)/t22-,24-,27+/m1/s1
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n/an/a 1.20n/an/an/an/an/an/a



Shionogi & Co., Ltd.

US Patent


Assay Description
Seven point five μL per well of human TrkA (PV3144, Lifetechnologies, final concentration: 1 nmol/L) suspended in the assay buffer (100 mmol/L 4...


US Patent US10640495 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM441115
PNG
(US10640495, Example I-332)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2ccc(CN=S(C)(C)=O)cc2)[C@@H](O1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C32H36F2N6O4S/c1-21-29(23-12-10-22(11-13-23)19-35-45(3,4)42)38-40(25-8-6-5-7-9-25)31(21)37-32(41)36-28-20-39(16-17-43-2)44-30(28)24-14-15-26(33)27(34)18-24/h5-15,18,28,30H,16-17,19-20H2,1-4H3,(H2,36,37,41)/t28-,30+/m1/s1
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n/an/a 1.20n/an/an/an/an/an/a



Shionogi & Co., Ltd.

US Patent


Assay Description
Seven point five μL per well of human TrkA (PV3144, Lifetechnologies, final concentration: 1 nmol/L) suspended in the assay buffer (100 mmol/L 4...


US Patent US10640495 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM441068
PNG
(US10640495, Example I-73)
Show SMILES CNC(=O)c1cc(cnc1OC)-c1nn(c(NC(=O)N[C@@H]2CN(CCOC)O[C@H]2c2cnc(F)c(F)c2)c1C)-c1ccccc1
Show InChI InChI=1S/C30H32F2N8O5/c1-17-24(18-12-21(28(41)33-2)29(44-4)35-14-18)38-40(20-8-6-5-7-9-20)27(17)37-30(42)36-23-16-39(10-11-43-3)45-25(23)19-13-22(31)26(32)34-15-19/h5-9,12-15,23,25H,10-11,16H2,1-4H3,(H,33,41)(H2,36,37,42)/t23-,25+/m1/s1
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Shionogi & Co., Ltd.

US Patent


Assay Description
Seven point five μL per well of human TrkA (PV3144, Lifetechnologies, final concentration: 1 nmol/L) suspended in the assay buffer (100 mmol/L 4...


US Patent US10640495 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM441095
PNG
(US10640495, Example I-253)
Show SMILES CNC(=O)c1ncc(cc1C)-c1nn(c(NC(=O)N[C@@H]2CN(CCOC)O[C@H]2c2cnc(F)c(F)c2)c1C)-c1ccccc1
Show InChI InChI=1S/C30H32F2N8O4/c1-17-12-19(14-34-24(17)29(41)33-3)25-18(2)28(40(38-25)21-8-6-5-7-9-21)37-30(42)36-23-16-39(10-11-43-4)44-26(23)20-13-22(31)27(32)35-15-20/h5-9,12-15,23,26H,10-11,16H2,1-4H3,(H,33,41)(H2,36,37,42)/t23-,26+/m1/s1
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Shionogi & Co., Ltd.

US Patent


Assay Description
Seven point five μL per well of human TrkA (PV3144, Lifetechnologies, final concentration: 1 nmol/L) suspended in the assay buffer (100 mmol/L 4...


US Patent US10640495 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM441125
PNG
(US10640495, Example I-323 | US10640495, Example I-...)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2ccc(OC)nc2)[C@@H](O1)c1ccnc(F)c1
Show InChI InChI=1S/C28H30FN7O4/c1-18-25(20-9-10-24(39-3)31-16-20)34-36(21-7-5-4-6-8-21)27(18)33-28(37)32-22-17-35(13-14-38-2)40-26(22)19-11-12-30-23(29)15-19/h4-12,15-16,22,26H,13-14,17H2,1-3H3,(H2,32,33,37)/t22-,26+/m1/s1
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Shionogi & Co., Ltd.

US Patent


Assay Description
Seven point five μL per well of human TrkA (PV3144, Lifetechnologies, final concentration: 1 nmol/L) suspended in the assay buffer (100 mmol/L 4...


US Patent US10640495 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM441061
PNG
(US10640495, Example I-36)
Show SMILES CCN1CCC(CC1)NC(=O)c1ccc(cc1)-c1nn(c(NC(=O)N[C@@H]2CN(CCOC)O[C@H]2c2ccc(F)c(F)c2)c1C)-c1ccccc1
Show InChI InChI=1S/C37H43F2N7O4/c1-4-44-18-16-28(17-19-44)40-36(47)26-12-10-25(11-13-26)33-24(2)35(46(43-33)29-8-6-5-7-9-29)42-37(48)41-32-23-45(20-21-49-3)50-34(32)27-14-15-30(38)31(39)22-27/h5-15,22,28,32,34H,4,16-21,23H2,1-3H3,(H,40,47)(H2,41,42,48)/t32-,34+/m1/s1
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Shionogi & Co., Ltd.

US Patent


Assay Description
Seven point five μL per well of human TrkA (PV3144, Lifetechnologies, final concentration: 1 nmol/L) suspended in the assay buffer (100 mmol/L 4...


US Patent US10640495 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM441089
PNG
(US10640495, Example I-236 | US10640495, Example I-...)
Show SMILES COCC[C@@H]1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2cnc3n(C)ncc3c2)[C@@H](O1)c1ccnc(F)c1
Show InChI InChI=1S/C30H31FN8O3/c1-18-26(20-13-21-17-34-38(2)29(21)33-16-20)37-39(22-7-5-4-6-8-22)28(18)36-30(40)35-24-15-23(10-12-41-3)42-27(24)19-9-11-32-25(31)14-19/h4-9,11,13-14,16-17,23-24,27H,10,12,15H2,1-3H3,(H2,35,36,40)/t23-,24-,27+/m1/s1
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Shionogi & Co., Ltd.

US Patent


Assay Description
Seven point five μL per well of human TrkA (PV3144, Lifetechnologies, final concentration: 1 nmol/L) suspended in the assay buffer (100 mmol/L 4...


US Patent US10640495 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM441132
PNG
(US10640495, Example I-638)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2ccc(CN(C)C)nc2)[C@@H](O1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C31H35F2N7O3/c1-20-28(22-10-12-23(34-17-22)18-38(2)3)37-40(24-8-6-5-7-9-24)30(20)36-31(41)35-27-19-39(14-15-42-4)43-29(27)21-11-13-25(32)26(33)16-21/h5-13,16-17,27,29H,14-15,18-19H2,1-4H3,(H2,35,36,41)/t27-,29+/m1/s1
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Shionogi & Co., Ltd.

US Patent


Assay Description
Seven point five μL per well of human TrkA (PV3144, Lifetechnologies, final concentration: 1 nmol/L) suspended in the assay buffer (100 mmol/L 4...


US Patent US10640495 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM441088
PNG
(US10640495, Example I-233)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2ccnc(c2)C(=O)NOC)[C@@H](O1)c1cnc(F)c(F)c1
Show InChI InChI=1S/C29H30F2N8O5/c1-17-24(18-9-10-32-22(14-18)28(40)37-43-3)36-39(20-7-5-4-6-8-20)27(17)35-29(41)34-23-16-38(11-12-42-2)44-25(23)19-13-21(30)26(31)33-15-19/h4-10,13-15,23,25H,11-12,16H2,1-3H3,(H,37,40)(H2,34,35,41)/t23-,25+/m1/s1
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Shionogi & Co., Ltd.

US Patent


Assay Description
Seven point five μL per well of human TrkA (PV3144, Lifetechnologies, final concentration: 1 nmol/L) suspended in the assay buffer (100 mmol/L 4...


US Patent US10640495 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM441107
PNG
(US10640495, Example I-303)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2cnc3N(C)C(=O)Cc3c2)[C@@H](O1)c1cnc(F)c(F)c1
Show InChI InChI=1S/C30H30F2N8O4/c1-17-25(19-11-18-13-24(41)38(2)29(18)34-14-19)37-40(21-7-5-4-6-8-21)28(17)36-30(42)35-23-16-39(9-10-43-3)44-26(23)20-12-22(31)27(32)33-15-20/h4-8,11-12,14-15,23,26H,9-10,13,16H2,1-3H3,(H2,35,36,42)/t23-,26+/m1/s1
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Shionogi & Co., Ltd.

US Patent


Assay Description
Seven point five μL per well of human TrkA (PV3144, Lifetechnologies, final concentration: 1 nmol/L) suspended in the assay buffer (100 mmol/L 4...


US Patent US10640495 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM441117
PNG
(US10640495, Example I-356)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2cnc3NC(=O)CNc3c2)[C@@H](O1)c1ccnc(F)c1
Show InChI InChI=1S/C29H30FN9O4/c1-17-25(19-12-21-27(33-14-19)35-24(40)15-32-21)37-39(20-6-4-3-5-7-20)28(17)36-29(41)34-22-16-38(10-11-42-2)43-26(22)18-8-9-31-23(30)13-18/h3-9,12-14,22,26,32H,10-11,15-16H2,1-2H3,(H,33,35,40)(H2,34,36,41)/t22-,26+/m1/s1
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Shionogi & Co., Ltd.

US Patent


Assay Description
Seven point five μL per well of human TrkA (PV3144, Lifetechnologies, final concentration: 1 nmol/L) suspended in the assay buffer (100 mmol/L 4...


US Patent US10640495 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM441069
PNG
(US10640495, Example I-79)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2cnc3n(C)n(C)c(=O)c3c2)[C@@H](O1)c1cnc(F)c(F)c1
Show InChI InChI=1S/C30H31F2N9O4/c1-17-24(18-12-21-28(34-14-18)38(2)39(3)29(21)42)37-41(20-8-6-5-7-9-20)27(17)36-30(43)35-23-16-40(10-11-44-4)45-25(23)19-13-22(31)26(32)33-15-19/h5-9,12-15,23,25H,10-11,16H2,1-4H3,(H2,35,36,43)/t23-,25+/m1/s1
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Shionogi & Co., Ltd.

US Patent


Assay Description
Seven point five μL per well of human TrkA (PV3144, Lifetechnologies, final concentration: 1 nmol/L) suspended in the assay buffer (100 mmol/L 4...


US Patent US10640495 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM441065
PNG
(US10640495, Example I-211 | US10640495, Example I-...)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2cnc(OC)nc2)[C@@H](O1)c1cnc(F)c(F)c1
Show InChI InChI=1S/C27H28F2N8O4/c1-16-22(18-13-31-27(40-3)32-14-18)35-37(19-7-5-4-6-8-19)25(16)34-26(38)33-21-15-36(9-10-39-2)41-23(21)17-11-20(28)24(29)30-12-17/h4-8,11-14,21,23H,9-10,15H2,1-3H3,(H2,33,34,38)/t21-,23+/m1/s1
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Shionogi & Co., Ltd.

US Patent


Assay Description
Seven point five μL per well of human TrkA (PV3144, Lifetechnologies, final concentration: 1 nmol/L) suspended in the assay buffer (100 mmol/L 4...


US Patent US10640495 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM441067
PNG
(US10640495, Example I-186 | US10640495, Example I-...)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2ccc(N=S(C)(C)=O)nc2)[C@@H](O1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C30H33F2N7O4S/c1-19-27(21-11-13-26(33-17-21)37-44(3,4)41)36-39(22-8-6-5-7-9-22)29(19)35-30(40)34-25-18-38(14-15-42-2)43-28(25)20-10-12-23(31)24(32)16-20/h5-13,16-17,25,28H,14-15,18H2,1-4H3,(H2,34,35,40)/t25-,28+/m1/s1
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Shionogi & Co., Ltd.

US Patent


Assay Description
Seven point five μL per well of human TrkA (PV3144, Lifetechnologies, final concentration: 1 nmol/L) suspended in the assay buffer (100 mmol/L 4...


US Patent US10640495 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM441063
PNG
(US10640495, Example I-40 | US10640495, Example I-6...)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2cnc3n(C)ncc3c2)[C@@H](O1)c1ccnc(F)c1
Show InChI InChI=1S/C29H30FN9O3/c1-18-25(20-13-21-16-33-37(2)28(21)32-15-20)36-39(22-7-5-4-6-8-22)27(18)35-29(40)34-23-17-38(11-12-41-3)42-26(23)19-9-10-31-24(30)14-19/h4-10,13-16,23,26H,11-12,17H2,1-3H3,(H2,34,35,40)/t23-,26+/m1/s1
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Shionogi & Co., Ltd.

US Patent


Assay Description
Seven point five μL per well of human TrkA (PV3144, Lifetechnologies, final concentration: 1 nmol/L) suspended in the assay buffer (100 mmol/L 4...


US Patent US10640495 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM441114
PNG
(US10640495, Example I-329)
Show SMILES COCC[C@@H]1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2cnc3N(C)C(=O)Cc3c2)[C@@H](O1)c1ccnc(F)c1
Show InChI InChI=1S/C31H32FN7O4/c1-18-27(21-13-20-15-26(40)38(2)30(20)34-17-21)37-39(22-7-5-4-6-8-22)29(18)36-31(41)35-24-16-23(10-12-42-3)43-28(24)19-9-11-33-25(32)14-19/h4-9,11,13-14,17,23-24,28H,10,12,15-16H2,1-3H3,(H2,35,36,41)/t23-,24-,28+/m1/s1
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Shionogi & Co., Ltd.

US Patent


Assay Description
Seven point five μL per well of human TrkA (PV3144, Lifetechnologies, final concentration: 1 nmol/L) suspended in the assay buffer (100 mmol/L 4...


US Patent US10640495 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM441128
PNG
(US10640495, Example I-552)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(OCCCN(C)C)nn2-c2ccccc2)[C@@H](O1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C28H36F2N6O4/c1-19-26(36(21-9-6-5-7-10-21)33-27(19)39-15-8-13-34(2)3)32-28(37)31-24-18-35(14-16-38-4)40-25(24)20-11-12-22(29)23(30)17-20/h5-7,9-12,17,24-25H,8,13-16,18H2,1-4H3,(H2,31,32,37)/t24-,25+/m1/s1
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Shionogi & Co., Ltd.

US Patent


Assay Description
Seven point five μL per well of human TrkA (PV3144, Lifetechnologies, final concentration: 1 nmol/L) suspended in the assay buffer (100 mmol/L 4...


US Patent US10640495 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM441101
PNG
(US10640495, Example I-279)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2cnc3NC(=O)COc3c2)[C@@H](O1)c1ccnc(F)c1
Show InChI InChI=1S/C29H29FN8O5/c1-17-25(19-12-22-27(32-14-19)34-24(39)16-42-22)36-38(20-6-4-3-5-7-20)28(17)35-29(40)33-21-15-37(10-11-41-2)43-26(21)18-8-9-31-23(30)13-18/h3-9,12-14,21,26H,10-11,15-16H2,1-2H3,(H,32,34,39)(H2,33,35,40)/t21-,26+/m1/s1
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Shionogi & Co., Ltd.

US Patent


Assay Description
Seven point five μL per well of human TrkA (PV3144, Lifetechnologies, final concentration: 1 nmol/L) suspended in the assay buffer (100 mmol/L 4...


US Patent US10640495 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM441103
PNG
(US10640495, Example I-291)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2cnc3N(C)C(=O)Cc3c2)[C@@H](O1)c1ccnc(F)c1
Show InChI InChI=1S/C30H31FN8O4/c1-18-26(21-13-20-15-25(40)37(2)29(20)33-16-21)36-39(22-7-5-4-6-8-22)28(18)35-30(41)34-23-17-38(11-12-42-3)43-27(23)19-9-10-32-24(31)14-19/h4-10,13-14,16,23,27H,11-12,15,17H2,1-3H3,(H2,34,35,41)/t23-,27+/m1/s1
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Shionogi & Co., Ltd.

US Patent


Assay Description
Seven point five μL per well of human TrkA (PV3144, Lifetechnologies, final concentration: 1 nmol/L) suspended in the assay buffer (100 mmol/L 4...


US Patent US10640495 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM441108
PNG
(US10640495, Example I-309)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2ccc3nc(cn3c2)C(N)=O)[C@@H](O1)c1cnc(F)c(F)c1
Show InChI InChI=1S/C30H29F2N9O4/c1-17-25(18-8-9-24-35-23(28(33)42)15-39(24)14-18)38-41(20-6-4-3-5-7-20)29(17)37-30(43)36-22-16-40(10-11-44-2)45-26(22)19-12-21(31)27(32)34-13-19/h3-9,12-15,22,26H,10-11,16H2,1-2H3,(H2,33,42)(H2,36,37,43)/t22-,26+/m1/s1
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Shionogi & Co., Ltd.

US Patent


Assay Description
Seven point five μL per well of human TrkA (PV3144, Lifetechnologies, final concentration: 1 nmol/L) suspended in the assay buffer (100 mmol/L 4...


US Patent US10640495 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM441079
PNG
(US10640495, Example I-159 | US10640495, Example I-...)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2ccc3nc(C)nn3c2)[C@@H](O1)c1ccnc(F)c1
Show InChI InChI=1S/C29H30FN9O3/c1-18-26(21-9-10-25-32-19(2)35-38(25)16-21)36-39(22-7-5-4-6-8-22)28(18)34-29(40)33-23-17-37(13-14-41-3)42-27(23)20-11-12-31-24(30)15-20/h4-12,15-16,23,27H,13-14,17H2,1-3H3,(H2,33,34,40)/t23-,27+/m1/s1
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Shionogi & Co., Ltd.

US Patent


Assay Description
Seven point five μL per well of human TrkA (PV3144, Lifetechnologies, final concentration: 1 nmol/L) suspended in the assay buffer (100 mmol/L 4...


US Patent US10640495 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM441105
PNG
(US10640495, Example I-299)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2cnc3[nH]ncc3c2)[C@@H](O1)c1ccnc(F)c1
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Shionogi & Co., Ltd.

US Patent


Assay Description
Seven point five μL per well of human TrkA (PV3144, Lifetechnologies, final concentration: 1 nmol/L) suspended in the assay buffer (100 mmol/L 4...


US Patent US10640495 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM441082
PNG
(US10640495, Example I-190)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2ccnc(c2)C(O)=O)[C@@H](O1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C29H28F2N6O5/c1-17-25(18-10-11-32-23(15-18)28(38)39)35-37(20-6-4-3-5-7-20)27(17)34-29(40)33-24-16-36(12-13-41-2)42-26(24)19-8-9-21(30)22(31)14-19/h3-11,14-15,24,26H,12-13,16H2,1-2H3,(H,38,39)(H2,33,34,40)/t24-,26+/m1/s1
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Shionogi & Co., Ltd.

US Patent


Assay Description
Seven point five μL per well of human TrkA (PV3144, Lifetechnologies, final concentration: 1 nmol/L) suspended in the assay buffer (100 mmol/L 4...


US Patent US10640495 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM441119
PNG
(US10640495, Example I-406)
Show SMILES CCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2cnc(OC)c(c2)C(=O)NC)[C@@H](O1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C30H31F2N7O4/c1-5-38-16-24(26(43-38)18-11-12-22(31)23(32)14-18)35-30(41)36-27-17(2)25(37-39(27)20-9-7-6-8-10-20)19-13-21(28(40)33-3)29(42-4)34-15-19/h6-15,24,26H,5,16H2,1-4H3,(H,33,40)(H2,35,36,41)/t24-,26+/m1/s1
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Shionogi & Co., Ltd.

US Patent


Assay Description
Seven point five μL per well of human TrkA (PV3144, Lifetechnologies, final concentration: 1 nmol/L) suspended in the assay buffer (100 mmol/L 4...


US Patent US10640495 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM441065
PNG
(US10640495, Example I-211 | US10640495, Example I-...)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2cnc(OC)nc2)[C@@H](O1)c1cnc(F)c(F)c1
Show InChI InChI=1S/C27H28F2N8O4/c1-16-22(18-13-31-27(40-3)32-14-18)35-37(19-7-5-4-6-8-19)25(16)34-26(38)33-21-15-36(9-10-39-2)41-23(21)17-11-20(28)24(29)30-12-17/h4-8,11-14,21,23H,9-10,15H2,1-3H3,(H2,33,34,38)/t21-,23+/m1/s1
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Shionogi & Co., Ltd.

US Patent


Assay Description
Seven point five μL per well of human TrkA (PV3144, Lifetechnologies, final concentration: 1 nmol/L) suspended in the assay buffer (100 mmol/L 4...


US Patent US10640495 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM441073
PNG
(US10640495, Example I-119 | US10640495, Example I-...)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2cnc(OC)nc2)[C@@H](O1)c1ccnc(F)c1
Show InChI InChI=1S/C27H29FN8O4/c1-17-23(19-14-30-27(39-3)31-15-19)34-36(20-7-5-4-6-8-20)25(17)33-26(37)32-21-16-35(11-12-38-2)40-24(21)18-9-10-29-22(28)13-18/h4-10,13-15,21,24H,11-12,16H2,1-3H3,(H2,32,33,37)/t21-,24+/m1/s1
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Shionogi & Co., Ltd.

US Patent


Assay Description
Seven point five μL per well of human TrkA (PV3144, Lifetechnologies, final concentration: 1 nmol/L) suspended in the assay buffer (100 mmol/L 4...


US Patent US10640495 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM441059
PNG
(US10640495, Example I-28)
Show SMILES COCC[C@@H]1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2cnc(C)nc2)[C@@H](O1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C29H30F2N6O3/c1-17-26(20-15-32-18(2)33-16-20)36-37(21-7-5-4-6-8-21)28(17)35-29(38)34-25-14-22(11-12-39-3)40-27(25)19-9-10-23(30)24(31)13-19/h4-10,13,15-16,22,25,27H,11-12,14H2,1-3H3,(H2,34,35,38)/t22-,25-,27+/m1/s1
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Shionogi & Co., Ltd.

US Patent


Assay Description
Seven point five μL per well of human TrkA (PV3144, Lifetechnologies, final concentration: 1 nmol/L) suspended in the assay buffer (100 mmol/L 4...


US Patent US10640495 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM441120
PNG
(US10640495, Example I-413)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2cnc3n(ncc3c2)C2CCN(C)CC2)[C@@H](O1)c1ccnc(F)c1
Show InChI InChI=1S/C34H39FN10O3/c1-22-30(24-17-25-20-38-44(33(25)37-19-24)27-10-13-42(2)14-11-27)41-45(26-7-5-4-6-8-26)32(22)40-34(46)39-28-21-43(15-16-47-3)48-31(28)23-9-12-36-29(35)18-23/h4-9,12,17-20,27-28,31H,10-11,13-16,21H2,1-3H3,(H2,39,40,46)/t28-,31+/m1/s1
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Shionogi & Co., Ltd.

US Patent


Assay Description
Seven point five μL per well of human TrkA (PV3144, Lifetechnologies, final concentration: 1 nmol/L) suspended in the assay buffer (100 mmol/L 4...


US Patent US10640495 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM441081
PNG
(US10640495, Example I-166 | US10640495, Example I-...)
Show SMILES CNC(=O)c1ncc(cc1C)-c1nn(c(NC(=O)N[C@@H]2CN(CCOC)O[C@H]2c2ccnc(F)c2)c1C)-c1ccccc1
Show InChI InChI=1S/C30H33FN8O4/c1-18-14-21(16-34-25(18)29(40)32-3)26-19(2)28(39(37-26)22-8-6-5-7-9-22)36-30(41)35-23-17-38(12-13-42-4)43-27(23)20-10-11-33-24(31)15-20/h5-11,14-16,23,27H,12-13,17H2,1-4H3,(H,32,40)(H2,35,36,41)/t23-,27+/m1/s1
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Shionogi & Co., Ltd.

US Patent


Assay Description
Seven point five μL per well of human TrkA (PV3144, Lifetechnologies, final concentration: 1 nmol/L) suspended in the assay buffer (100 mmol/L 4...


US Patent US10640495 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM441102
PNG
(US10640495, Example I-285 | US10640495, Example I-...)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2cnc(C)nc2)[C@@H](O1)c1cc(F)nc(F)c1
Show InChI InChI=1S/C27H28F2N8O3/c1-16-24(19-13-30-17(2)31-14-19)35-37(20-7-5-4-6-8-20)26(16)34-27(38)32-21-15-36(9-10-39-3)40-25(21)18-11-22(28)33-23(29)12-18/h4-8,11-14,21,25H,9-10,15H2,1-3H3,(H2,32,34,38)/t21-,25+/m1/s1
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Shionogi & Co., Ltd.

US Patent


Assay Description
Seven point five μL per well of human TrkA (PV3144, Lifetechnologies, final concentration: 1 nmol/L) suspended in the assay buffer (100 mmol/L 4...


US Patent US10640495 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM441074
PNG
(US10640495, Example I-122)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2cnc3n(C)c(=O)oc3c2)[C@@H](O1)c1ccnc(F)c1
Show InChI InChI=1S/C29H29FN8O5/c1-17-24(19-13-22-27(32-15-19)36(2)29(40)42-22)35-38(20-7-5-4-6-8-20)26(17)34-28(39)33-21-16-37(11-12-41-3)43-25(21)18-9-10-31-23(30)14-18/h4-10,13-15,21,25H,11-12,16H2,1-3H3,(H2,33,34,39)/t21-,25+/m1/s1
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Shionogi & Co., Ltd.

US Patent


Assay Description
Seven point five μL per well of human TrkA (PV3144, Lifetechnologies, final concentration: 1 nmol/L) suspended in the assay buffer (100 mmol/L 4...


US Patent US10640495 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM441058
PNG
(US10640495, Example I-25)
Show SMILES COCC[C@@H]1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2cnn(C)c2)[C@@H](O1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C28H30F2N6O3/c1-17-25(19-15-31-35(2)16-19)34-36(20-7-5-4-6-8-20)27(17)33-28(37)32-24-14-21(11-12-38-3)39-26(24)18-9-10-22(29)23(30)13-18/h4-10,13,15-16,21,24,26H,11-12,14H2,1-3H3,(H2,32,33,37)/t21-,24-,26+/m1/s1
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Shionogi & Co., Ltd.

US Patent


Assay Description
Seven point five μL per well of human TrkA (PV3144, Lifetechnologies, final concentration: 1 nmol/L) suspended in the assay buffer (100 mmol/L 4...


US Patent US10640495 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM441099
PNG
(US10640495, Example I-275)
Show SMILES COCC[C@@H]1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2cnc3n(C)nnc3c2)[C@@H](O1)c1ccnc(F)c1
Show InChI InChI=1S/C29H30FN9O3/c1-17-25(19-13-23-28(32-16-19)38(2)37-35-23)36-39(20-7-5-4-6-8-20)27(17)34-29(40)33-22-15-21(10-12-41-3)42-26(22)18-9-11-31-24(30)14-18/h4-9,11,13-14,16,21-22,26H,10,12,15H2,1-3H3,(H2,33,34,40)/t21-,22-,26+/m1/s1
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Shionogi & Co., Ltd.

US Patent


Assay Description
Seven point five μL per well of human TrkA (PV3144, Lifetechnologies, final concentration: 1 nmol/L) suspended in the assay buffer (100 mmol/L 4...


US Patent US10640495 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM441094
PNG
(US10640495, Example I-245 | US10640495, Example I-...)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2cnn(C)c2)[C@@H](O1)c1cnc(F)c(F)c1
Show InChI InChI=1S/C26H28F2N8O3/c1-16-22(18-13-30-34(2)14-18)33-36(19-7-5-4-6-8-19)25(16)32-26(37)31-21-15-35(9-10-38-3)39-23(21)17-11-20(27)24(28)29-12-17/h4-8,11-14,21,23H,9-10,15H2,1-3H3,(H2,31,32,37)/t21-,23+/m1/s1
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Shionogi & Co., Ltd.

US Patent


Assay Description
Seven point five μL per well of human TrkA (PV3144, Lifetechnologies, final concentration: 1 nmol/L) suspended in the assay buffer (100 mmol/L 4...


US Patent US10640495 (2020)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%