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Patent code US10646492

Compile Data Set for Download or QSAR

Found 366 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM255790
PNG
(1-{1-[5-Chloro-3-(1-isopropylazetidin-3-yl)-2-meth...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C1)C(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H29ClN6O/c1-11(2)28-8-15(9-28)18-12(3)17(23)7-16(20(18)30-6)14(5)29-22-19(13(4)27-29)21(24)25-10-26-22/h7,10-11,14-15H,8-9H2,1-6H3,(H2,24,25,26)
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n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US10646492 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM255793
PNG
(1-(1-{5-Chloro-3-[1-(cyclopropylmethyl)azetidin-3-...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(CC2CC2)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H29ClN6O/c1-12-18(24)7-17(14(3)30-23-20(13(2)28-30)22(25)26-11-27-23)21(31-4)19(12)16-9-29(10-16)8-15-5-6-15/h7,11,14-16H,5-6,8-10H2,1-4H3,(H2,25,26,27)
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n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US10646492 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM255800
PNG
(5-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H26ClN7O2/c1-12-17(25)9-16(14(3)32-23-20(13(2)30-32)22(26)28-11-29-23)21(34-6)19(12)15-7-8-18(27-10-15)24(33)31(4)5/h7-11,14H,1-6H3,(H2,26,28,29)
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n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US10646492 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM255826
PNG
(4-Amino-8-{1-[5-chloro-2-ethoxy-3-(1-isopropylazet...)
Show SMILES CCOc1c(cc(Cl)c(C)c1C1CN(C1)C(C)C)C(C)n1ccc(=O)c2c(N)ncnc12
Show InChI InChI=1S/C24H30ClN5O2/c1-6-32-22-17(9-18(25)14(4)20(22)16-10-29(11-16)13(2)3)15(5)30-8-7-19(31)21-23(26)27-12-28-24(21)30/h7-9,12-13,15-16H,6,10-11H2,1-5H3,(H2,26,27,28)
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n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US10646492 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM255828
PNG
(6-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES CCNC(=O)c1c(C)c(Cl)cc(C(C)n2nc(C)c3c(N)ncnc23)c1-c1cc(F)cc(F)c1
Show InChI InChI=1S/C24H23ClF2N6O/c1-5-29-24(34)19-11(2)18(25)9-17(21(19)14-6-15(26)8-16(27)7-14)13(4)33-23-20(12(3)32-33)22(28)30-10-31-23/h6-10,13H,5H2,1-4H3,(H,29,34)(H2,28,30,31)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US10646492 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM289056
PNG
(US10092570, Example 57 | US10376513, Example 57 | ...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(-c2cncc(c2)C#N)c2c(N)ncnc12
Show InChI InChI=1S/C30H28ClN9O2/c1-6-42-27-21(10-22(31)16(2)24(27)19-7-8-23(35-14-19)30(41)39(4)5)17(3)40-29-25(28(33)36-15-37-29)26(38-40)20-9-18(11-32)12-34-13-20/h7-10,12-15,17H,6H2,1-5H3,(H2,33,36,37)
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n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US10646492 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM255854
PNG
(1-{1-[5-chloro-2-methoxy-4-methyl-3-(1-oxetan-3-yl...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C1)C1COC1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H27ClN6O2/c1-11-17(23)5-16(13(3)29-22-19(12(2)27-29)21(24)25-10-26-22)20(30-4)18(11)14-6-28(7-14)15-8-31-9-15/h5,10,13-15H,6-9H2,1-4H3,(H2,24,25,26)
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n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US10646492 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM255856
PNG
(5-{3-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1cncc(c1)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H26ClN7O2/c1-12-18(25)8-17(14(3)32-23-20(13(2)30-32)22(26)28-11-29-23)21(34-6)19(12)15-7-16(10-27-9-15)24(33)31(4)5/h7-11,14H,1-6H3,(H2,26,28,29)
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n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US10646492 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261099
PNG
(1-[(3-{3-[1-(4-Amino-3-methyl- 1H-pyrazolo[3,4-d]p...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C1)C(=O)C1(O)CC1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H27ClN6O3/c1-11-16(24)7-15(13(3)30-21-18(12(2)28-30)20(25)26-10-27-21)19(33-4)17(11)14-8-29(9-14)22(31)23(32)5-6-23/h7,10,13-14,32H,5-6,8-9H2,1-4H3,(H2,25,26,27)
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n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US10646492 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261103
PNG
(US10092570, Example 126 | US10646492, Example 126 ...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(CC#N)C1)C(C)n1nc(-c2cn[nH]c2)c2c(N)ncnc12
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n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US10646492 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261108
PNG
(5-{1-[4-Amino-3-(difluoromethyl)-1H-pyrazolo[3,4-d...)
Show SMILES COc1c(cc(C#N)c(C)c1C1CN(C[C@H](C)O)C1)C(C)n1nc(C(F)F)c2c(N)ncnc12
Show InChI InChI=1S/C23H27F2N7O2/c1-11(33)7-31-8-15(9-31)17-12(2)14(6-26)5-16(20(17)34-4)13(3)32-23-18(19(30-32)21(24)25)22(27)28-10-29-23/h5,10-11,13,15,21,33H,7-9H2,1-4H3,(H2,27,28,29)/t11-,13?/m0/s1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US10646492 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261115
PNG
(3-(1-Acetylazetidin-3-yl)-5-{1-[4-amino-3-(difluor...)
Show SMILES COc1c(cc(C#N)c(C)c1C1CN(C1)C(C)=O)C(C)n1nc(C(F)F)c2c(N)ncnc12
Show InChI InChI=1S/C22H23F2N7O2/c1-10-13(6-25)5-15(19(33-4)16(10)14-7-30(8-14)12(3)32)11(2)31-22-17(18(29-31)20(23)24)21(26)27-9-28-22/h5,9,11,14,20H,7-8H2,1-4H3,(H2,26,27,28)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US10646492 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261120
PNG
((2S)-1-(3-{3-[1-(4-Amino-3- methyl-1H-pyrazolo[3,4...)
Show SMILES CCOc1c(cc(Cl)c(F)c1C1CN(C[C@H](C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H28ClFN6O2/c1-5-32-20-15(13(4)30-22-17(12(3)28-30)21(25)26-10-27-22)6-16(23)19(24)18(20)14-8-29(9-14)7-11(2)31/h6,10-11,13-14,31H,5,7-9H2,1-4H3,(H2,25,26,27)/t11-,13?/m0/s1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US10646492 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261120
PNG
((2S)-1-(3-{3-[1-(4-Amino-3- methyl-1H-pyrazolo[3,4...)
Show SMILES CCOc1c(cc(Cl)c(F)c1C1CN(C[C@H](C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H28ClFN6O2/c1-5-32-20-15(13(4)30-22-17(12(3)28-30)21(25)26-10-27-22)6-16(23)19(24)18(20)14-8-29(9-14)7-11(2)31/h6,10-11,13-14,31H,5,7-9H2,1-4H3,(H2,25,26,27)/t11-,13?/m0/s1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US10646492 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261129
PNG
(2-[3-(3-{-1-[4-Amino-3-(difluoromethyl)-1H-pyrazol...)
Show SMILES CCOc1c(cc(Cl)c(F)c1C1CN(CCO)C1)C(C)n1nc(C(F)F)c2c(N)ncnc12
Show InChI InChI=1S/C21H24ClF3N6O2/c1-3-33-18-12(6-13(22)16(23)14(18)11-7-30(8-11)4-5-32)10(2)31-21-15(17(29-31)19(24)25)20(26)27-9-28-21/h6,9-11,19,32H,3-5,7-8H2,1-2H3,(H2,26,27,28)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US10646492 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM289161
PNG
(3-(3-{3-[1-(4-Amino-3-methyl- 1H-pyrazolo[3,4-d]py...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(CC(C)C#N)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H28ClN7O/c1-12(7-25)8-30-9-16(10-30)19-13(2)18(24)6-17(21(19)32-5)15(4)31-23-20(14(3)29-31)22(26)27-11-28-23/h6,11-12,15-16H,8-10H2,1-5H3,(H2,26,27,28)
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n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US10646492 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261143
PNG
(3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CC(O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C20H24ClN5O2/c1-9-15(21)7-14(18(28-4)16(9)12-5-13(27)6-12)11(3)26-20-17(10(2)25-26)19(22)23-8-24-20/h7-8,11-13,27H,5-6H2,1-4H3,(H2,22,23,24)
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n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US10646492 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261157
PNG
(3-(3-(1-(4-Amino-3-methyl-1H- pyrazolo[3,4-d]pyrim...)
Show SMILES COc1c(cc(Cl)c(C)c1CCC(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H27ClN6O2/c1-11-14(7-8-17(29)27(4)5)19(30-6)15(9-16(11)22)13(3)28-21-18(12(2)26-28)20(23)24-10-25-21/h9-10,13H,7-8H2,1-6H3,(H2,23,24,25)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US10646492 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261251
PNG
(US10092570, Example 274 | US10376513, Example 274 ...)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(C1)C1COC1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H24ClN7O2/c1-11-18-21(25)26-10-27-22(18)30(28-11)12(2)15-4-17(23)16(5-24)19(20(15)31-3)13-6-29(7-13)14-8-32-9-14/h4,10,12-14H,6-9H2,1-3H3,(H2,25,26,27)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US10646492 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261060
PNG
(5-(3-{1-[4-Amino-3-(hydroxymethyl)-1H-pyrazolo[3,4...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(CO)c2c(N)ncnc12
Show InChI InChI=1S/C25H28ClN7O3/c1-6-36-22-16(14(3)33-24-21(19(11-34)31-33)23(27)29-12-30-24)9-17(26)13(2)20(22)15-7-8-18(28-10-15)25(35)32(4)5/h7-10,12,14,34H,6,11H2,1-5H3,(H2,27,29,30)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US10646492 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261063
PNG
(5-(3-{1-[4-Amino-3-(fluoromethyl)-1H-pyrazolo[3,4-...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(CF)c2c(N)ncnc12
Show InChI InChI=1S/C25H27ClFN7O2/c1-6-36-22-16(14(3)34-24-21(19(10-27)32-34)23(28)30-12-31-24)9-17(26)13(2)20(22)15-7-8-18(29-11-15)25(35)33(4)5/h7-9,11-12,14H,6,10H2,1-5H3,(H2,28,30,31)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US10646492 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261073
PNG
((2S)-1-(3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-...)
Show SMILES CCOc1c(cc(Cl)c(C)c1C1CN(C[C@H](C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H31ClN6O2/c1-6-32-21-17(15(5)30-23-20(14(4)28-30)22(25)26-11-27-23)7-18(24)13(3)19(21)16-9-29(10-16)8-12(2)31/h7,11-12,15-16,31H,6,8-10H2,1-5H3,(H2,25,26,27)/t12-,15?/m0/s1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US10646492 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261082
PNG
((3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrim...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(CC#N)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H24ClN7O/c1-11-16(22)7-15(19(30-4)17(11)14-8-28(9-14)6-5-23)13(3)29-21-18(12(2)27-29)20(24)25-10-26-21/h7,10,13-14H,6,8-9H2,1-4H3,(H2,24,25,26)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US10646492 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261085
PNG
(1-(1-{5-Chloro-2-methoxy-4-methyl-3-[1-(2,2,2-trif...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(CC(F)(F)F)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H24ClF3N6O/c1-10-15(22)5-14(12(3)31-20-17(11(2)29-31)19(26)27-9-28-20)18(32-4)16(10)13-6-30(7-13)8-21(23,24)25/h5,9,12-13H,6-8H2,1-4H3,(H2,26,27,28)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US10646492 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261258
PNG
(2-(1-Acetylazetidin-3-yl)-4-[1-(4-amino-3-methyl-1...)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(C1)C(C)=O)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H22ClN7O2/c1-10-17-20(24)25-9-26-21(17)29(27-10)11(2)14-5-16(22)15(6-23)18(19(14)31-4)13-7-28(8-13)12(3)30/h5,9,11,13H,7-8H2,1-4H3,(H2,24,25,26)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US10646492 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261272
PNG
(US10092570, Example 295 | US10376513, Example 295 ...)
Show SMILES CCNC(=O)N1CC(C1)c1c(OC)c(cc(Cl)c1C#N)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H25ClN8O2/c1-5-26-22(32)30-8-13(9-30)18-15(7-24)16(23)6-14(19(18)33-4)12(3)31-21-17(11(2)29-31)20(25)27-10-28-21/h6,10,12-13H,5,8-9H2,1-4H3,(H,26,32)(H2,25,27,28)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US10646492 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM289297
PNG
(US10092570, Example 298 | US10646492, Example 298 ...)
Show SMILES CCN1CC(C1)c1c(Cl)c(Cl)cc(C(C)n2nc(C)c3c(N)ncnc23)c1OC
Show InChI InChI=1S/C20H24Cl2N6O/c1-5-27-7-12(8-27)16-17(22)14(21)6-13(18(16)29-4)11(3)28-20-15(10(2)26-28)19(23)24-9-25-20/h6,9,11-12H,5,7-8H2,1-4H3,(H2,23,24,25)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US10646492 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261203
PNG
(US10092570, Example 226 | US10376513, Example 226 ...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(C1)C(COC)COC)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H32ClN7O3/c1-6-36-23-18(15(3)33-25-21(14(2)31-33)24(28)29-13-30-25)7-20(26)19(8-27)22(23)16-9-32(10-16)17(11-34-4)12-35-5/h7,13,15-17H,6,9-12H2,1-5H3,(H2,28,29,30)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US10646492 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261214
PNG
(4-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(C1)C(C)(C)CO)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H30ClN7O2/c1-6-34-21-16(14(3)32-23-19(13(2)30-32)22(27)28-12-29-23)7-18(25)17(8-26)20(21)15-9-31(10-15)24(4,5)11-33/h7,12,14-15,33H,6,9-11H2,1-5H3,(H2,27,28,29)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US10646492 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261217
PNG
(US10092570, Example 240 | US10376513, Example 240 ...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(C1)C(C)(C)C(=O)NC)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H31ClN8O2/c1-7-36-21-16(14(3)34-23-19(13(2)32-34)22(28)30-12-31-23)8-18(26)17(9-27)20(21)15-10-33(11-15)25(4,5)24(35)29-6/h8,12,14-15H,7,10-11H2,1-6H3,(H,29,35)(H2,28,30,31)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US10646492 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261219
PNG
(US10092570, Example 242 | US10376513, Example 242 ...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(C1)C(C)=O)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H24ClN7O2/c1-5-32-20-15(12(3)30-22-18(11(2)28-30)21(25)26-10-27-22)6-17(23)16(7-24)19(20)14-8-29(9-14)13(4)31/h6,10,12,14H,5,8-9H2,1-4H3,(H2,25,26,27)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US10646492 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261228
PNG
(US10092570, Example 251 | US10376513, Example 251 ...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(C1)S(=O)(=O)C1CC1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H26ClN7O3S/c1-4-34-21-16(13(3)31-23-19(12(2)29-31)22(26)27-11-28-23)7-18(24)17(8-25)20(21)14-9-30(10-14)35(32,33)15-5-6-15/h7,11,13-15H,4-6,9-10H2,1-3H3,(H2,26,27,28)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US10646492 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261229
PNG
(US10092570, Example 252 | US10376513, Example 252 ...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(C1)C(=O)OC)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H24ClN7O3/c1-5-33-19-14(12(3)30-21-17(11(2)28-30)20(25)26-10-27-21)6-16(23)15(7-24)18(19)13-8-29(9-13)22(31)32-4/h6,10,12-13H,5,8-9H2,1-4H3,(H2,25,26,27)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US10646492 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261290
PNG
(4-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1-c1ccc(nc1)C(C)(C)O)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H26ClN7O2/c1-6-35-22-16(14(3)33-24-20(13(2)32-33)23(28)30-12-31-24)9-18(26)17(10-27)21(22)15-7-8-19(29-11-15)25(4,5)34/h7-9,11-12,14,34H,6H2,1-5H3,(H2,28,30,31)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US10646492 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261294
PNG
(4-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES CCOc1c(cc(C)c(C#N)c1C1CN(C1)C(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H31N7O/c1-7-32-22-18(16(6)31-24-20(15(5)29-31)23(26)27-12-28-24)8-14(4)19(9-25)21(22)17-10-30(11-17)13(2)3/h8,12-13,16-17H,7,10-11H2,1-6H3,(H2,26,27,28)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US10646492 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM334166
PNG
(4-[1-(4-amino-3-methyl-1H- pyrazolo[3,4-d]pyrimidi...)
Show SMILES CCOc1c(cc(C)c(C#N)c1C1CN(C[C@H](C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H31N7O2/c1-6-33-22-18(16(5)31-24-20(15(4)29-31)23(26)27-12-28-24)7-13(2)19(8-25)21(22)17-10-30(11-17)9-14(3)32/h7,12,14,16-17,32H,6,9-11H2,1-5H3,(H2,26,27,28)/t14-,16?/m0/s1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US10646492 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM442138
PNG
(4-[-1-(4-amino-3-methyl-1H- pyrazolo[3,4-d]pyrimid...)
Show SMILES CCCN1CC(C1)c1c(OCC)c(cc(C)c1C#N)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H31N7O/c1-6-8-30-11-17(12-30)21-19(10-25)14(3)9-18(22(21)32-7-2)16(5)31-24-20(15(4)29-31)23(26)27-13-28-24/h9,13,16-17H,6-8,11-12H2,1-5H3,(H2,26,27,28)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US10646492 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM442156
PNG
(US10646492, Example 310 | US10646492, Example 311)
Show SMILES CCOc1c(cc(Cl)c(C)c1[C@H]1CNC(=O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H25ClN6O2/c1-5-30-19-14(7-15(22)10(2)17(19)13-6-16(29)24-8-13)12(4)28-21-18(11(3)27-28)20(23)25-9-26-21/h7,9,12-13H,5-6,8H2,1-4H3,(H,24,29)(H2,23,25,26)/t12?,13-/m1/s1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US10646492 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261340
PNG
(5-{3-[1-(4-Amino-6-methyl-5-oxopyrido[2,3-d]pyrimi...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1cc(C)c(=O)c2c(N)ncnc12
Show InChI InChI=1S/C26H27ClN6O3/c1-13-11-33(25-21(22(13)34)24(28)30-12-31-25)15(3)17-9-18(27)14(2)20(23(17)36-6)16-7-8-19(29-10-16)26(35)32(4)5/h7-12,15H,1-6H3,(H2,28,30,31)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US10646492 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261233
PNG
(US10092570, Example 256 | US10376513, Example 256 ...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(C1)C(N)=O)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H23ClN8O2/c1-4-32-18-13(11(3)30-20-16(10(2)28-30)19(24)26-9-27-20)5-15(22)14(6-23)17(18)12-7-29(8-12)21(25)31/h5,9,11-12H,4,7-8H2,1-3H3,(H2,25,31)(H2,24,26,27)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US10646492 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM255794
PNG
(1-{1-[5-chloro-2-methoxy-4-methyl-3-(1-methylazeti...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C20H25ClN6O/c1-10-15(21)6-14(18(28-5)16(10)13-7-26(4)8-13)12(3)27-20-17(11(2)25-27)19(22)23-9-24-20/h6,9,12-13H,7-8H2,1-5H3,(H2,22,23,24)
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n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US10646492 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM255797
PNG
(1-{1-[3-(1-sec-butylazetidin-3-yl)-5-chloro-2-meth...)
Show SMILES CCC(C)N1CC(C1)c1c(C)c(Cl)cc(C(C)n2nc(C)c3c(N)ncnc23)c1OC
Show InChI InChI=1S/C23H31ClN6O/c1-7-12(2)29-9-16(10-29)19-13(3)18(24)8-17(21(19)31-6)15(5)30-23-20(14(4)28-30)22(25)26-11-27-23/h8,11-12,15-16H,7,9-10H2,1-6H3,(H2,25,26,27)
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n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US10646492 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM255806
PNG
(4-(3-(1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES CNC(=O)c1cc(ccn1)-c1c(C)c(Cl)cc(C(C)n2nc(C)c3c(N)ncnc23)c1OC
Show InChI InChI=1S/C23H24ClN7O2/c1-11-16(24)9-15(13(3)31-22-19(12(2)30-31)21(25)28-10-29-22)20(33-5)18(11)14-6-7-27-17(8-14)23(32)26-4/h6-10,13H,1-5H3,(H,26,32)(H2,25,28,29)
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n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US10646492 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM255836
PNG
(5-{3-[1-(4-amino-5-oxopyrido[2,3-d]pyrimidin-8(5H)...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1ccc(=O)c2c(N)ncnc12
Show InChI InChI=1S/C26H24ClN7O3/c1-5-37-23-16(14(2)34-9-8-20(35)22-24(29)31-13-32-25(22)34)10-18(27)17(11-28)21(23)15-6-7-19(30-12-15)26(36)33(3)4/h6-10,12-14H,5H2,1-4H3,(H2,29,31,32)
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n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US10646492 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM441861
PNG
(US10646492, Example 52)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(-c2ccn(CCO)n2)c2c(N)ncnc12
Show InChI InChI=1S/C29H32ClN9O3/c1-6-42-26-19(13-20(30)16(2)23(26)18-7-8-22(32-14-18)29(41)37(4)5)17(3)39-28-24(27(31)33-15-34-28)25(36-39)21-9-10-38(35-21)11-12-40/h7-10,13-15,17,40H,6,11-12H2,1-5H3,(H2,31,33,34)
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n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US10646492 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM255849
PNG
(5-(3-{1-[4-amino-3-(2-aminopyrimidin-5-yl)-1H-pyra...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(-c2cnc(N)nc2)c2c(N)ncnc12
Show InChI InChI=1S/C28H29ClN10O2/c1-6-41-24-18(9-19(29)14(2)21(24)16-7-8-20(32-10-16)27(40)38(4)5)15(3)39-26-22(25(30)35-13-36-26)23(37-39)17-11-33-28(31)34-12-17/h7-13,15H,6H2,1-5H3,(H2,30,35,36)(H2,31,33,34)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US10646492 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM255850
PNG
(5-{3-[1-(4-amino-3-{6-[(methylamino)carbonyl]pyrid...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(-c2ccc(nc2)C(=O)NC)c2c(N)ncnc12
Show InChI InChI=1S/C31H32ClN9O3/c1-7-44-27-20(12-21(32)16(2)24(27)18-8-11-23(36-13-18)31(43)40(5)6)17(3)41-29-25(28(33)37-15-38-29)26(39-41)19-9-10-22(35-14-19)30(42)34-4/h8-15,17H,7H2,1-6H3,(H,34,42)(H2,33,37,38)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US10646492 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM255800
PNG
(5-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H26ClN7O2/c1-12-17(25)9-16(14(3)32-23-20(13(2)30-32)22(26)28-11-29-23)21(34-6)19(12)15-7-8-18(27-10-15)24(33)31(4)5/h7-11,14H,1-6H3,(H2,26,28,29)
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n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US10646492 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM255861
PNG
(1-(3-{3-[1-(4-Amino-3-methyl-1H- pyrazolo[3,4-d]py...)
Show SMILES COc1c(cc(Cl)c(F)c1C1CN(CC(C)(C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H28ClFN6O2/c1-11-16-20(25)26-10-27-21(16)30(28-11)12(2)14-6-15(23)18(24)17(19(14)32-5)13-7-29(8-13)9-22(3,4)31/h6,10,12-13,31H,7-9H2,1-5H3,(H2,25,26,27)
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n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US10646492 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261100
PNG
(1-(3-{3-[1-(4-Amino-3-methyl-1H- pyrazolo[3,4-d]py...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C1)C(=O)C(C)(C)O)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H29ClN6O3/c1-11-16(24)7-15(13(3)30-21-18(12(2)28-30)20(25)26-10-27-21)19(33-6)17(11)14-8-29(9-14)22(31)23(4,5)32/h7,10,13-14,32H,8-9H2,1-6H3,(H2,25,26,27)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US10646492 (2020)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%