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Patent code US10646575

Compile Data Set for Download or QSAR
Found 3 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
CRBN-DDB1


(Homo sapiens (Human))		BDBM441811
PNG
(US10646575, Compound 3)
Show SMILES O=C1N(C2CC3(CC3)C(=O)NC2=O)C(=O)c2ccccc12
Show InChI InChI=1S/C15H12N2O4/c18-11-10(7-15(5-6-15)14(21)16-11)17-12(19)8-3-1-2-4-9(8)13(17)20/h1-4,10H,5-7H2,(H,16,18,21)
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n/an/an/a 5.01E+5n/an/an/an/an/a



C4 Therapeutics, Inc.

US Patent


Assay Description
Measuring compound ligand binding to CRBN-DDB1 was carried out using an established sensitive and quantitative in vitro fluorescence polarization (FP...

US Patent US10646575 (2020)

More data for this
Ligand-Target Pair
CRBN-DDB1


(Homo sapiens (Human))		BDBM441810
PNG
(US10646575, Compound 2)
Show SMILES [O-][N+](=O)c1cccc2C(=O)N(C3CCCC(=O)NC3=O)C(=O)c12
Show InChI InChI=1S/C14H11N3O6/c18-10-6-2-5-9(12(19)15-10)16-13(20)7-3-1-4-8(17(22)23)11(7)14(16)21/h1,3-4,9H,2,5-6H2,(H,15,18,19)
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n/an/an/a>1.00E+5n/an/an/an/an/a



C4 Therapeutics, Inc.

US Patent


Assay Description
Measuring compound ligand binding to CRBN-DDB1 was carried out using an established sensitive and quantitative in vitro fluorescence polarization (FP...

US Patent US10646575 (2020)

More data for this
Ligand-Target Pair
CRBN-DDB1


(Homo sapiens (Human))		BDBM441791
PNG
(US10646575, Compound 1)
Show SMILES O=C1CC(N2Cc3ccccc3C2=O)C(=O)N1
Show InChI InChI=1S/C12H10N2O3/c15-10-5-9(11(16)13-10)14-6-7-3-1-2-4-8(7)12(14)17/h1-4,9H,5-6H2,(H,13,15,16)
PDB

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UniProtKB/SwissProt

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UniChem
US Patent
n/an/an/a>1.00E+5n/an/an/an/an/a



C4 Therapeutics, Inc.

US Patent


Assay Description
Measuring compound ligand binding to CRBN-DDB1 was carried out using an established sensitive and quantitative in vitro fluorescence polarization (FP...

US Patent US10646575 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%