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Patent code US10647686

Compile Data Set for Download or QSAR
Found 82 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase 17A


(Homo sapiens (Human))
BDBM441855
PNG
(US10647686, Example (3))
Show SMILES CC(C)c1ccc(Nc2ncc(Cl)c(NCCCN)n2)cc1
Show InChI InChI=1S/C16H22ClN5/c1-11(2)12-4-6-13(7-5-12)21-16-20-10-14(17)15(22-16)19-9-3-8-18/h4-7,10-11H,3,8-9,18H2,1-2H3,(H2,19,20,21,22)
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n/an/a 11n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens (Human))
BDBM441866
PNG
(US10647686, Example (13))
Show SMILES NCCCNc1nc(Nc2ccc(cc2)S(=O)(=O)c2ccc(cc2)[N+]([O-])=O)ncc1Cl
Show InChI InChI=1S/C19H19ClN6O4S/c20-17-12-23-19(25-18(17)22-11-1-10-21)24-13-2-6-15(7-3-13)31(29,30)16-8-4-14(5-9-16)26(27)28/h2-9,12H,1,10-11,21H2,(H2,22,23,24,25)
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n/an/a 14n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens (Human))
BDBM441876
PNG
(US10647686, Example (23))
Show SMILES NCCCNc1nc(Nc2ccc3CCCCc3c2)ncc1Cl
Show InChI InChI=1S/C17H22ClN5/c18-15-11-21-17(23-16(15)20-9-3-8-19)22-14-7-6-12-4-1-2-5-13(12)10-14/h6-7,10-11H,1-5,8-9,19H2,(H2,20,21,22,23)
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n/an/a 15n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens (Human))
BDBM441873
PNG
(US10647686, Example (20))
Show SMILES NCCCNc1nc(Nc2ccc3OCOc3c2)ncc1Cl
Show InChI InChI=1S/C14H16ClN5O2/c15-10-7-18-14(20-13(10)17-5-1-4-16)19-9-2-3-11-12(6-9)22-8-21-11/h2-3,6-7H,1,4-5,8,16H2,(H2,17,18,19,20)
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n/an/a 16n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens (Human))
BDBM441878
PNG
(US10647686, Example (24))
Show SMILES NCCCNc1nc(Nc2ccc3C(=O)CCCc3c2)ncc1Cl
Show InChI InChI=1S/C17H20ClN5O/c18-14-10-21-17(23-16(14)20-8-2-7-19)22-12-5-6-13-11(9-12)3-1-4-15(13)24/h5-6,9-10H,1-4,7-8,19H2,(H2,20,21,22,23)
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n/an/a 19n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens (Human))
BDBM441862
PNG
(US10647686, Example (9))
Show SMILES NCCCNc1nc(Nc2ccc(F)cc2)ncc1Cl
Show InChI InChI=1S/C13H15ClFN5/c14-11-8-18-13(20-12(11)17-7-1-6-16)19-10-4-2-9(15)3-5-10/h2-5,8H,1,6-7,16H2,(H2,17,18,19,20)
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n/an/a 19n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens (Human))
BDBM441882
PNG
(US10647686, Example (26))
Show SMILES NCCCNc1nc(Nc2ccc(cc2)C2CCNCC2)ncc1Cl
Show InChI InChI=1S/C18H25ClN6/c19-16-12-23-18(25-17(16)22-9-1-8-20)24-15-4-2-13(3-5-15)14-6-10-21-11-7-14/h2-5,12,14,21H,1,6-11,20H2,(H2,22,23,24,25)
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n/an/a 19n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens (Human))
BDBM441874
PNG
(US10647686, Example (21))
Show SMILES NCCCNc1nc(Nc2ccc3CCCc3c2)ncc1Cl
Show InChI InChI=1S/C16H20ClN5/c17-14-10-20-16(22-15(14)19-8-2-7-18)21-13-6-5-11-3-1-4-12(11)9-13/h5-6,9-10H,1-4,7-8,18H2,(H2,19,20,21,22)
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n/an/a 21n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens (Human))
BDBM441881
PNG
(US10647686, Example (25))
Show SMILES NCCCNc1nc(Nc2ccc(cc2)N2CCNCC2)ncc1Cl
Show InChI InChI=1S/C17H24ClN7/c18-15-12-22-17(24-16(15)21-7-1-6-19)23-13-2-4-14(5-3-13)25-10-8-20-9-11-25/h2-5,12,20H,1,6-11,19H2,(H2,21,22,23,24)
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n/an/a 22n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens (Human))
BDBM441872
PNG
(US10647686, Example (19) | US10647686, Example 19)
Show SMILES Cc1cnc(Nc2ccc(Cl)cc2)nc1NCCCN
Show InChI InChI=1S/C14H18ClN5/c1-10-9-18-14(20-13(10)17-8-2-7-16)19-12-5-3-11(15)4-6-12/h3-6,9H,2,7-8,16H2,1H3,(H2,17,18,19,20)
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n/an/a 23n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens (Human))
BDBM441872
PNG
(US10647686, Example (19) | US10647686, Example 19)
Show SMILES Cc1cnc(Nc2ccc(Cl)cc2)nc1NCCCN
Show InChI InChI=1S/C14H18ClN5/c1-10-9-18-14(20-13(10)17-8-2-7-16)19-12-5-3-11(15)4-6-12/h3-6,9H,2,7-8,16H2,1H3,(H2,17,18,19,20)
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n/an/a 23n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens (Human))
BDBM441872
PNG
(US10647686, Example (19) | US10647686, Example 19)
Show SMILES Cc1cnc(Nc2ccc(Cl)cc2)nc1NCCCN
Show InChI InChI=1S/C14H18ClN5/c1-10-9-18-14(20-13(10)17-8-2-7-16)19-12-5-3-11(15)4-6-12/h3-6,9H,2,7-8,16H2,1H3,(H2,17,18,19,20)
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n/an/a 23n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens (Human))
BDBM441870
PNG
(US10647686, Example (17))
Show SMILES NCCCNc1nc(Nc2ccc(Br)cc2)ncc1Cl
Show InChI InChI=1S/C13H15BrClN5/c14-9-2-4-10(5-3-9)19-13-18-8-11(15)12(20-13)17-7-1-6-16/h2-5,8H,1,6-7,16H2,(H2,17,18,19,20)
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n/an/a 23n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens (Human))
BDBM441875
PNG
(US10647686, Example (22))
Show SMILES NCCCNc1nc(Nc2ccc3OCCOc3c2)ncc1Cl
Show InChI InChI=1S/C15H18ClN5O2/c16-11-9-19-15(21-14(11)18-5-1-4-17)20-10-2-3-12-13(8-10)23-7-6-22-12/h2-3,8-9H,1,4-7,17H2,(H2,18,19,20,21)
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n/an/a 24n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens (Human))
BDBM441858
PNG
(US10647686, Example (6))
Show SMILES Cc1ccc(Nc2ncc(Cl)c(NCCCN)n2)cc1Cl
Show InChI InChI=1S/C14H17Cl2N5/c1-9-3-4-10(7-11(9)15)20-14-19-8-12(16)13(21-14)18-6-2-5-17/h3-4,7-8H,2,5-6,17H2,1H3,(H2,18,19,20,21)
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n/an/a 24n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens (Human))
BDBM441854
PNG
(US10647686, Example (2))
Show SMILES NCCCNc1nc(Nc2cc(Cl)cc(Cl)c2)ncc1Cl
Show InChI InChI=1S/C13H14Cl3N5/c14-8-4-9(15)6-10(5-8)20-13-19-7-11(16)12(21-13)18-3-1-2-17/h4-7H,1-3,17H2,(H2,18,19,20,21)
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n/an/a 26n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens (Human))
BDBM441868
PNG
(US10647686, Example (15))
Show SMILES NCCCNc1nc(Nc2ccc(F)c(c2)C(F)(F)F)ncc1Cl
Show InChI InChI=1S/C14H14ClF4N5/c15-10-7-22-13(24-12(10)21-5-1-4-20)23-8-2-3-11(16)9(6-8)14(17,18)19/h2-3,6-7H,1,4-5,20H2,(H2,21,22,23,24)
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n/an/a 26n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens (Human))
BDBM441863
PNG
(US10647686, Example (10))
Show SMILES NCCCNc1nc(Nc2ccc(Oc3ccccc3)cc2)ncc1Cl
Show InChI InChI=1S/C19H20ClN5O/c20-17-13-23-19(25-18(17)22-12-4-11-21)24-14-7-9-16(10-8-14)26-15-5-2-1-3-6-15/h1-3,5-10,13H,4,11-12,21H2,(H2,22,23,24,25)
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n/an/a 26n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens (Human))
BDBM441904
PNG
(US10647686, Comparative Example 6)
Show SMILES NCCCNc1nc(Nc2ccc(Cl)cc2)ncc1Br
Show InChI InChI=1S/C13H15BrClN5/c14-11-8-18-13(20-12(11)17-7-1-6-16)19-10-4-2-9(15)3-5-10/h2-5,8H,1,6-7,16H2,(H2,17,18,19,20)
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n/an/a 27n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens (Human))
BDBM441904
PNG
(US10647686, Comparative Example 6)
Show SMILES NCCCNc1nc(Nc2ccc(Cl)cc2)ncc1Br
Show InChI InChI=1S/C13H15BrClN5/c14-11-8-18-13(20-12(11)17-7-1-6-16)19-10-4-2-9(15)3-5-10/h2-5,8H,1,6-7,16H2,(H2,17,18,19,20)
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n/an/a 27n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B (STK17B)


(Homo sapiens (Human))
BDBM441881
PNG
(US10647686, Example (25))
Show SMILES NCCCNc1nc(Nc2ccc(cc2)N2CCNCC2)ncc1Cl
Show InChI InChI=1S/C17H24ClN7/c18-15-12-22-17(24-16(15)21-7-1-6-19)23-13-2-4-14(5-3-13)25-10-8-20-9-11-25/h2-5,12,20H,1,6-11,19H2,(H2,21,22,23,24)
PDB

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n/an/a 30n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens (Human))
BDBM441898
PNG
(US10647686, Example (41))
Show SMILES NCCCCNc1nc(Nc2cc(Cl)cc(Cl)c2)ncc1Cl
Show InChI InChI=1S/C14H16Cl3N5/c15-9-5-10(16)7-11(6-9)21-14-20-8-12(17)13(22-14)19-4-2-1-3-18/h5-8H,1-4,18H2,(H2,19,20,21,22)
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n/an/a 31n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens (Human))
BDBM441905
PNG
(US10647686, Example 1)
Show SMILES CC(C)(C)OC(=O)NCCCNc1nc(Cl)ncc1Cl
Show InChI InChI=1S/C12H18Cl2N4O2/c1-12(2,3)20-11(19)16-6-4-5-15-9-8(13)7-17-10(14)18-9/h7H,4-6H2,1-3H3,(H,16,19)(H,15,17,18)
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n/an/a 32n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens (Human))
BDBM441869
PNG
(US10647686, Example (16))
Show SMILES NCCCNc1nc(Nc2ccc(Br)c(c2)C(F)(F)F)ncc1Cl
Show InChI InChI=1S/C14H14BrClF3N5/c15-10-3-2-8(6-9(10)14(17,18)19)23-13-22-7-11(16)12(24-13)21-5-1-4-20/h2-3,6-7H,1,4-5,20H2,(H2,21,22,23,24)
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n/an/a 34n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens (Human))
BDBM441895
PNG
(US10647686, Example (38))
Show SMILES Cc1cnc(Nc2ccc(F)c(Cl)c2)nc1NCCCN
Show InChI InChI=1S/C14H17ClFN5/c1-9-8-19-14(21-13(9)18-6-2-5-17)20-10-3-4-12(16)11(15)7-10/h3-4,7-8H,2,5-6,17H2,1H3,(H2,18,19,20,21)
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n/an/a 35n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens (Human))
BDBM441871
PNG
(US10647686, Example (18))
Show SMILES COc1ccc(Nc2ncc(Cl)c(NCCCN)n2)cc1Cl
Show InChI InChI=1S/C14H17Cl2N5O/c1-22-12-4-3-9(7-10(12)15)20-14-19-8-11(16)13(21-14)18-6-2-5-17/h3-4,7-8H,2,5-6,17H2,1H3,(H2,18,19,20,21)
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n/an/a 35n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens (Human))
BDBM441867
PNG
(US10647686, Example (14))
Show SMILES Cc1ccc(Nc2ncc(Cl)c(NCCCN)n2)cc1C
Show InChI InChI=1S/C15H20ClN5/c1-10-4-5-12(8-11(10)2)20-15-19-9-13(16)14(21-15)18-7-3-6-17/h4-5,8-9H,3,6-7,17H2,1-2H3,(H2,18,19,20,21)
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n/an/a 37n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens (Human))
BDBM441905
PNG
(US10647686, Example 1)
Show SMILES CC(C)(C)OC(=O)NCCCNc1nc(Cl)ncc1Cl
Show InChI InChI=1S/C12H18Cl2N4O2/c1-12(2,3)20-11(19)16-6-4-5-15-9-8(13)7-17-10(14)18-9/h7H,4-6H2,1-3H3,(H,16,19)(H,15,17,18)
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n/an/a 38n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens (Human))
BDBM441853
PNG
(US10647686, Example (1))
Show SMILES NCCCNc1nc(Nc2ccc(Cl)cc2)ncc1Cl
Show InChI InChI=1S/C13H15Cl2N5/c14-9-2-4-10(5-3-9)19-13-18-8-11(15)12(20-13)17-7-1-6-16/h2-5,8H,1,6-7,16H2,(H2,17,18,19,20)
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n/an/a 38n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B (STK17B)


(Homo sapiens (Human))
BDBM441904
PNG
(US10647686, Comparative Example 6)
Show SMILES NCCCNc1nc(Nc2ccc(Cl)cc2)ncc1Br
Show InChI InChI=1S/C13H15BrClN5/c14-11-8-18-13(20-12(11)17-7-1-6-16)19-10-4-2-9(15)3-5-10/h2-5,8H,1,6-7,16H2,(H2,17,18,19,20)
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n/an/a 40n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B (STK17B)


(Homo sapiens (Human))
BDBM441904
PNG
(US10647686, Comparative Example 6)
Show SMILES NCCCNc1nc(Nc2ccc(Cl)cc2)ncc1Br
Show InChI InChI=1S/C13H15BrClN5/c14-11-8-18-13(20-12(11)17-7-1-6-16)19-10-4-2-9(15)3-5-10/h2-5,8H,1,6-7,16H2,(H2,17,18,19,20)
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n/an/a 40n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens (Human))
BDBM441864
PNG
(US10647686, Example (11))
Show SMILES CCc1ccc(Nc2ncc(Cl)c(NCCCN)n2)cc1
Show InChI InChI=1S/C15H20ClN5/c1-2-11-4-6-12(7-5-11)20-15-19-10-13(16)14(21-15)18-9-3-8-17/h4-7,10H,2-3,8-9,17H2,1H3,(H2,18,19,20,21)
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n/an/a 44n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens (Human))
BDBM441897
PNG
(US10647686, Example (40) | US10647686, Example 40)
Show SMILES NCCCCNc1nc(Nc2ccc(Cl)cc2)ncc1Cl
Show InChI InChI=1S/C14H17Cl2N5/c15-10-3-5-11(6-4-10)20-14-19-9-12(16)13(21-14)18-8-2-1-7-17/h3-6,9H,1-2,7-8,17H2,(H2,18,19,20,21)
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n/an/a 47n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens (Human))
BDBM441897
PNG
(US10647686, Example (40) | US10647686, Example 40)
Show SMILES NCCCCNc1nc(Nc2ccc(Cl)cc2)ncc1Cl
Show InChI InChI=1S/C14H17Cl2N5/c15-10-3-5-11(6-4-10)20-14-19-9-12(16)13(21-14)18-8-2-1-7-17/h3-6,9H,1-2,7-8,17H2,(H2,18,19,20,21)
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n/an/a 47n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens (Human))
BDBM441865
PNG
(US10647686, Example (12))
Show SMILES CCCCCCc1ccc(Nc2ncc(Cl)c(NCCCN)n2)cc1
Show InChI InChI=1S/C19H28ClN5/c1-2-3-4-5-7-15-8-10-16(11-9-15)24-19-23-14-17(20)18(25-19)22-13-6-12-21/h8-11,14H,2-7,12-13,21H2,1H3,(H2,22,23,24,25)
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n/an/a 56n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens (Human))
BDBM441860
PNG
(US10647686, Example (8))
Show SMILES NCCCNc1nc(Nc2ccc(Cl)c(Cl)c2)ncc1Cl
Show InChI InChI=1S/C13H14Cl3N5/c14-9-3-2-8(6-10(9)15)20-13-19-7-11(16)12(21-13)18-5-1-4-17/h2-3,6-7H,1,4-5,17H2,(H2,18,19,20,21)
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n/an/a 59n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens (Human))
BDBM441859
PNG
(US10647686, Example (7))
Show SMILES NCCCNc1nc(Nc2ccc(F)c(Cl)c2)ncc1Cl
Show InChI InChI=1S/C13H14Cl2FN5/c14-9-6-8(2-3-11(9)16)20-13-19-7-10(15)12(21-13)18-5-1-4-17/h2-3,6-7H,1,4-5,17H2,(H2,18,19,20,21)
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n/an/a 70n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens (Human))
BDBM441896
PNG
(US10647686, Example (39))
Show SMILES Cc1cnc(Nc2ccc(Cl)c(Cl)c2)nc1NCCCN
Show InChI InChI=1S/C14H17Cl2N5/c1-9-8-19-14(21-13(9)18-6-2-5-17)20-10-3-4-11(15)12(16)7-10/h3-4,7-8H,2,5-6,17H2,1H3,(H2,18,19,20,21)
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n/an/a 75n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens (Human))
BDBM441856
PNG
(US10647686, Example (4))
Show SMILES CCCCCc1ccc(Nc2ncc(Cl)c(NCCCN)n2)cc1
Show InChI InChI=1S/C18H26ClN5/c1-2-3-4-6-14-7-9-15(10-8-14)23-18-22-13-16(19)17(24-18)21-12-5-11-20/h7-10,13H,2-6,11-12,20H2,1H3,(H2,21,22,23,24)
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n/an/a 80n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens (Human))
BDBM441894
PNG
(US10647686, Example (37))
Show SMILES Cc1ccc(Nc2ncc(C)c(NCCCN)n2)cc1C
Show InChI InChI=1S/C16H23N5/c1-11-5-6-14(9-12(11)2)20-16-19-10-13(3)15(21-16)18-8-4-7-17/h5-6,9-10H,4,7-8,17H2,1-3H3,(H2,18,19,20,21)
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n/an/a 82n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens (Human))
BDBM441892
PNG
(US10647686, Example (35))
Show SMILES Cc1cnc(Nc2ccc(Br)cc2)nc1NCCCN
Show InChI InChI=1S/C14H18BrN5/c1-10-9-18-14(20-13(10)17-8-2-7-16)19-12-5-3-11(15)4-6-12/h3-6,9H,2,7-8,16H2,1H3,(H2,17,18,19,20)
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n/an/a 89n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens (Human))
BDBM441883
PNG
(US10647686, Example (27))
Show SMILES Cc1ccc(Nc2ncc(C)c(NCCCN)n2)cc1Cl
Show InChI InChI=1S/C15H20ClN5/c1-10-4-5-12(8-13(10)16)20-15-19-9-11(2)14(21-15)18-7-3-6-17/h4-5,8-9H,3,6-7,17H2,1-2H3,(H2,18,19,20,21)
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n/an/a 98n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens (Human))
BDBM441886
PNG
(US10647686, Example (29))
Show SMILES Cc1cnc(Nc2ccc(cc2)N2CCNCC2)nc1NCCCN
Show InChI InChI=1S/C18H27N7/c1-14-13-22-18(24-17(14)21-8-2-7-19)23-15-3-5-16(6-4-15)25-11-9-20-10-12-25/h3-6,13,20H,2,7-12,19H2,1H3,(H2,21,22,23,24)
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n/an/a 100n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens (Human))
BDBM441893
PNG
(US10647686, Example (36))
Show SMILES Cc1cnc(Nc2ccc3OCCOc3c2)nc1NCCCN
Show InChI InChI=1S/C16H21N5O2/c1-11-10-19-16(21-15(11)18-6-2-5-17)20-12-3-4-13-14(9-12)23-8-7-22-13/h3-4,9-10H,2,5-8,17H2,1H3,(H2,18,19,20,21)
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n/an/a 110n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B (STK17B)


(Homo sapiens (Human))
BDBM441866
PNG
(US10647686, Example (13))
Show SMILES NCCCNc1nc(Nc2ccc(cc2)S(=O)(=O)c2ccc(cc2)[N+]([O-])=O)ncc1Cl
Show InChI InChI=1S/C19H19ClN6O4S/c20-17-12-23-19(25-18(17)22-11-1-10-21)24-13-2-6-15(7-3-13)31(29,30)16-8-4-14(5-9-16)26(27)28/h2-9,12H,1,10-11,21H2,(H2,22,23,24,25)
PDB

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n/an/a 110n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens (Human))
BDBM441907
PNG
(US10647686, Comparative Example 7)
Show SMILES NCCNc1nc(Nc2ccc(Cl)cc2)ncc1Cl
Show InChI InChI=1S/C12H13Cl2N5/c13-8-1-3-9(4-2-8)18-12-17-7-10(14)11(19-12)16-6-5-15/h1-4,7H,5-6,15H2,(H2,16,17,18,19)
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n/an/a 110n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens (Human))
BDBM441900
PNG
(US10647686, Comparative Example 2)
Show SMILES NCCCNc1nc(Nc2ccc(Cl)cc2)ncc1C(F)(F)F
Show InChI InChI=1S/C14H15ClF3N5/c15-9-2-4-10(5-3-9)22-13-21-8-11(14(16,17)18)12(23-13)20-7-1-6-19/h2-5,8H,1,6-7,19H2,(H2,20,21,22,23)
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n/an/a 120n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens (Human))
BDBM441909
PNG
(US10647686, Comparative Example 8)
Show SMILES Cc1cnc(Nc2ccc(Cl)cc2)nc1NCCN
Show InChI InChI=1S/C13H16ClN5/c1-9-8-17-13(19-12(9)16-7-6-15)18-11-4-2-10(14)3-5-11/h2-5,8H,6-7,15H2,1H3,(H2,16,17,18,19)
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n/an/a 140n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B (STK17B)


(Homo sapiens (Human))
BDBM441876
PNG
(US10647686, Example (23))
Show SMILES NCCCNc1nc(Nc2ccc3CCCCc3c2)ncc1Cl
Show InChI InChI=1S/C17H22ClN5/c18-15-11-21-17(23-16(15)20-9-3-8-19)22-14-7-6-12-4-1-2-5-13(12)10-14/h6-7,10-11H,1-5,8-9,19H2,(H2,20,21,22,23)
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n/an/a 160n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens (Human))
BDBM441887
PNG
(US10647686, Example (30))
Show SMILES Cc1cnc(Nc2ccc3CCCCc3c2)nc1NCCCN
Show InChI InChI=1S/C18H25N5/c1-13-12-21-18(23-17(13)20-10-4-9-19)22-16-8-7-14-5-2-3-6-15(14)11-16/h7-8,11-12H,2-6,9-10,19H2,1H3,(H2,20,21,22,23)
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n/an/a 160n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B (STK17B)


(Homo sapiens (Human))
BDBM441863
PNG
(US10647686, Example (10))
Show SMILES NCCCNc1nc(Nc2ccc(Oc3ccccc3)cc2)ncc1Cl
Show InChI InChI=1S/C19H20ClN5O/c20-17-13-23-19(25-18(17)22-12-4-11-21)24-14-7-9-16(10-8-14)26-15-5-2-1-3-6-15/h1-3,5-10,13H,4,11-12,21H2,(H2,22,23,24,25)
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n/an/a 180n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens (Human))
BDBM441888
PNG
(US10647686, Example (31))
Show SMILES Cc1cnc(Nc2ccc(F)c(c2)C(F)(F)F)nc1NCCCN
Show InChI InChI=1S/C15H17F4N5/c1-9-8-22-14(24-13(9)21-6-2-5-20)23-10-3-4-12(16)11(7-10)15(17,18)19/h3-4,7-8H,2,5-6,20H2,1H3,(H2,21,22,23,24)
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n/an/a 180n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B (STK17B)


(Homo sapiens (Human))
BDBM441871
PNG
(US10647686, Example (18))
Show SMILES COc1ccc(Nc2ncc(Cl)c(NCCCN)n2)cc1Cl
Show InChI InChI=1S/C14H17Cl2N5O/c1-22-12-4-3-9(7-10(12)15)20-14-19-8-11(16)13(21-14)18-6-2-5-17/h3-4,7-8H,2,5-6,17H2,1H3,(H2,18,19,20,21)
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n/an/a 180n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B (STK17B)


(Homo sapiens (Human))
BDBM441868
PNG
(US10647686, Example (15))
Show SMILES NCCCNc1nc(Nc2ccc(F)c(c2)C(F)(F)F)ncc1Cl
Show InChI InChI=1S/C14H14ClF4N5/c15-10-7-22-13(24-12(10)21-5-1-4-20)23-8-2-3-11(16)9(6-8)14(17,18)19/h2-3,6-7H,1,4-5,20H2,(H2,21,22,23,24)
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n/an/a 180n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens (Human))
BDBM441885
PNG
(US10647686, Example (28))
Show SMILES Cc1cnc(Nc2ccc(F)cc2)nc1NCCCN
Show InChI InChI=1S/C14H18FN5/c1-10-9-18-14(20-13(10)17-8-2-7-16)19-12-5-3-11(15)4-6-12/h3-6,9H,2,7-8,16H2,1H3,(H2,17,18,19,20)
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n/an/a 190n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B (STK17B)


(Homo sapiens (Human))
BDBM441859
PNG
(US10647686, Example (7))
Show SMILES NCCCNc1nc(Nc2ccc(F)c(Cl)c2)ncc1Cl
Show InChI InChI=1S/C13H14Cl2FN5/c14-9-6-8(2-3-11(9)16)20-13-19-7-10(15)12(21-13)18-5-1-4-17/h2-3,6-7H,1,4-5,17H2,(H2,18,19,20,21)
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n/an/a 200n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B (STK17B)


(Homo sapiens (Human))
BDBM441875
PNG
(US10647686, Example (22))
Show SMILES NCCCNc1nc(Nc2ccc3OCCOc3c2)ncc1Cl
Show InChI InChI=1S/C15H18ClN5O2/c16-11-9-19-15(21-14(11)18-5-1-4-17)20-10-2-3-12-13(8-10)23-7-6-22-12/h2-3,8-9H,1,4-7,17H2,(H2,18,19,20,21)
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n/an/a 220n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B (STK17B)


(Homo sapiens (Human))
BDBM441858
PNG
(US10647686, Example (6))
Show SMILES Cc1ccc(Nc2ncc(Cl)c(NCCCN)n2)cc1Cl
Show InChI InChI=1S/C14H17Cl2N5/c1-9-3-4-10(7-11(9)15)20-14-19-8-12(16)13(21-14)18-6-2-5-17/h3-4,7-8H,2,5-6,17H2,1H3,(H2,18,19,20,21)
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n/an/a 220n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B (STK17B)


(Homo sapiens (Human))
BDBM441867
PNG
(US10647686, Example (14))
Show SMILES Cc1ccc(Nc2ncc(Cl)c(NCCCN)n2)cc1C
Show InChI InChI=1S/C15H20ClN5/c1-10-4-5-12(8-11(10)2)20-15-19-9-13(16)14(21-15)18-7-3-6-17/h4-5,8-9H,3,6-7,17H2,1-2H3,(H2,18,19,20,21)
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n/an/a 220n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B (STK17B)


(Homo sapiens (Human))
BDBM441874
PNG
(US10647686, Example (21))
Show SMILES NCCCNc1nc(Nc2ccc3CCCc3c2)ncc1Cl
Show InChI InChI=1S/C16H20ClN5/c17-14-10-20-16(22-15(14)19-8-2-7-18)21-13-6-5-11-3-1-4-12(11)9-13/h5-6,9-10H,1-4,7-8,18H2,(H2,19,20,21,22)
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n/an/a 220n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B (STK17B)


(Homo sapiens (Human))
BDBM441878
PNG
(US10647686, Example (24))
Show SMILES NCCCNc1nc(Nc2ccc3C(=O)CCCc3c2)ncc1Cl
Show InChI InChI=1S/C17H20ClN5O/c18-14-10-21-17(23-16(14)20-8-2-7-19)22-12-5-6-13-11(9-12)3-1-4-15(13)24/h5-6,9-10H,1-4,7-8,19H2,(H2,20,21,22,23)
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n/an/a 230n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B (STK17B)


(Homo sapiens (Human))
BDBM441855
PNG
(US10647686, Example (3))
Show SMILES CC(C)c1ccc(Nc2ncc(Cl)c(NCCCN)n2)cc1
Show InChI InChI=1S/C16H22ClN5/c1-11(2)12-4-6-13(7-5-12)21-16-20-10-14(17)15(22-16)19-9-3-8-18/h4-7,10-11H,3,8-9,18H2,1-2H3,(H2,19,20,21,22)
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n/an/a 240n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B (STK17B)


(Homo sapiens (Human))
BDBM441862
PNG
(US10647686, Example (9))
Show SMILES NCCCNc1nc(Nc2ccc(F)cc2)ncc1Cl
Show InChI InChI=1S/C13H15ClFN5/c14-11-8-18-13(20-12(11)17-7-1-6-16)19-10-4-2-9(15)3-5-10/h2-5,8H,1,6-7,16H2,(H2,17,18,19,20)
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n/an/a 290n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens (Human))
BDBM441899
PNG
(US10647686, Comparative Example 1)
Show SMILES NCCCNc1nc(Nc2ccc(Cl)cc2)ncc1F
Show InChI InChI=1S/C13H15ClFN5/c14-9-2-4-10(5-3-9)19-13-18-8-11(15)12(20-13)17-7-1-6-16/h2-5,8H,1,6-7,16H2,(H2,17,18,19,20)
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n/an/a 300n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B (STK17B)


(Homo sapiens (Human))
BDBM441860
PNG
(US10647686, Example (8))
Show SMILES NCCCNc1nc(Nc2ccc(Cl)c(Cl)c2)ncc1Cl
Show InChI InChI=1S/C13H14Cl3N5/c14-9-3-2-8(6-10(9)15)20-13-19-7-11(16)12(21-13)18-5-1-4-17/h2-3,6-7H,1,4-5,17H2,(H2,18,19,20,21)
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n/an/a 310n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens (Human))
BDBM441903
PNG
(US10647686, Comparative Example 5)
Show SMILES NCCCNc1nc(Nc2ccc(Cl)cc2)ncc1[N+]([O-])=O
Show InChI InChI=1S/C13H15ClN6O2/c14-9-2-4-10(5-3-9)18-13-17-8-11(20(21)22)12(19-13)16-7-1-6-15/h2-5,8H,1,6-7,15H2,(H2,16,17,18,19)
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n/an/a 320n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens (Human))
BDBM441891
PNG
(US10647686, Example (34))
Show SMILES Cc1cnc(Nc2ccc(cc2)S(=O)(=O)c2ccc(cc2)[N+]([O-])=O)nc1NCCCN
Show InChI InChI=1S/C20H22N6O4S/c1-14-13-23-20(25-19(14)22-12-2-11-21)24-15-3-7-17(8-4-15)31(29,30)18-9-5-16(6-10-18)26(27)28/h3-10,13H,2,11-12,21H2,1H3,(H2,22,23,24,25)
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n/an/a 340n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B (STK17B)


(Homo sapiens (Human))
BDBM441873
PNG
(US10647686, Example (20))
Show SMILES NCCCNc1nc(Nc2ccc3OCOc3c2)ncc1Cl
Show InChI InChI=1S/C14H16ClN5O2/c15-10-7-18-14(20-13(10)17-5-1-4-16)19-9-2-3-11-12(6-9)22-8-21-11/h2-3,6-7H,1,4-5,8,16H2,(H2,17,18,19,20)
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n/an/a 350n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B (STK17B)


(Homo sapiens (Human))
BDBM441864
PNG
(US10647686, Example (11))
Show SMILES CCc1ccc(Nc2ncc(Cl)c(NCCCN)n2)cc1
Show InChI InChI=1S/C15H20ClN5/c1-2-11-4-6-12(7-5-11)20-15-19-10-13(16)14(21-15)18-9-3-8-17/h4-7,10H,2-3,8-9,17H2,1H3,(H2,18,19,20,21)
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n/an/a 370n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B (STK17B)


(Homo sapiens (Human))
BDBM441870
PNG
(US10647686, Example (17))
Show SMILES NCCCNc1nc(Nc2ccc(Br)cc2)ncc1Cl
Show InChI InChI=1S/C13H15BrClN5/c14-9-2-4-10(5-3-9)19-13-18-8-11(15)12(20-13)17-7-1-6-16/h2-5,8H,1,6-7,16H2,(H2,17,18,19,20)
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n/an/a 390n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B (STK17B)


(Homo sapiens (Human))
BDBM441905
PNG
(US10647686, Example 1)
Show SMILES CC(C)(C)OC(=O)NCCCNc1nc(Cl)ncc1Cl
Show InChI InChI=1S/C12H18Cl2N4O2/c1-12(2,3)20-11(19)16-6-4-5-15-9-8(13)7-17-10(14)18-9/h7H,4-6H2,1-3H3,(H,16,19)(H,15,17,18)
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n/an/a 410n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B (STK17B)


(Homo sapiens (Human))
BDBM441853
PNG
(US10647686, Example (1))
Show SMILES NCCCNc1nc(Nc2ccc(Cl)cc2)ncc1Cl
Show InChI InChI=1S/C13H15Cl2N5/c14-9-2-4-10(5-3-9)19-13-18-8-11(15)12(20-13)17-7-1-6-16/h2-5,8H,1,6-7,16H2,(H2,17,18,19,20)
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n/an/a 410n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B (STK17B)


(Homo sapiens (Human))
BDBM441897
PNG
(US10647686, Example (40) | US10647686, Example 40)
Show SMILES NCCCCNc1nc(Nc2ccc(Cl)cc2)ncc1Cl
Show InChI InChI=1S/C14H17Cl2N5/c15-10-3-5-11(6-4-10)20-14-19-9-12(16)13(21-14)18-8-2-1-7-17/h3-6,9H,1-2,7-8,17H2,(H2,18,19,20,21)
PDB

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n/an/a 480n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens (Human))
BDBM441890
PNG
(US10647686, Example (33))
Show SMILES Cc1cnc(Nc2ccc(Oc3ccccc3)cc2)nc1NCCCN
Show InChI InChI=1S/C20H23N5O/c1-15-14-23-20(25-19(15)22-13-5-12-21)24-16-8-10-18(11-9-16)26-17-6-3-2-4-7-17/h2-4,6-11,14H,5,12-13,21H2,1H3,(H2,22,23,24,25)
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n/an/a 490n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B (STK17B)


(Homo sapiens (Human))
BDBM441872
PNG
(US10647686, Example (19) | US10647686, Example 19)
Show SMILES Cc1cnc(Nc2ccc(Cl)cc2)nc1NCCCN
Show InChI InChI=1S/C14H18ClN5/c1-10-9-18-14(20-13(10)17-8-2-7-16)19-12-5-3-11(15)4-6-12/h3-6,9H,2,7-8,16H2,1H3,(H2,17,18,19,20)
PDB

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n/an/a 710n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B (STK17B)


(Homo sapiens (Human))
BDBM441872
PNG
(US10647686, Example (19) | US10647686, Example 19)
Show SMILES Cc1cnc(Nc2ccc(Cl)cc2)nc1NCCCN
Show InChI InChI=1S/C14H18ClN5/c1-10-9-18-14(20-13(10)17-8-2-7-16)19-12-5-3-11(15)4-6-12/h3-6,9H,2,7-8,16H2,1H3,(H2,17,18,19,20)
PDB

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n/an/a 710n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens (Human))
BDBM441857
PNG
(US10647686, Example (5))
Show SMILES CCCCCCCCc1ccc(Nc2ncc(Cl)c(NCCCN)n2)cc1
Show InChI InChI=1S/C21H32ClN5/c1-2-3-4-5-6-7-9-17-10-12-18(13-11-17)26-21-25-16-19(22)20(27-21)24-15-8-14-23/h10-13,16H,2-9,14-15,23H2,1H3,(H2,24,25,26,27)
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n/an/a 740n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B (STK17B)


(Homo sapiens (Human))
BDBM441869
PNG
(US10647686, Example (16))
Show SMILES NCCCNc1nc(Nc2ccc(Br)c(c2)C(F)(F)F)ncc1Cl
Show InChI InChI=1S/C14H14BrClF3N5/c15-10-3-2-8(6-9(10)14(17,18)19)23-13-22-7-11(16)12(24-13)21-5-1-4-20/h2-3,6-7H,1,4-5,20H2,(H2,21,22,23,24)
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n/an/a 740n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens (Human))
BDBM441901
PNG
(US10647686, Comparative Example 3)
Show SMILES COc1cnc(Nc2ccc(Cl)cc2)nc1NCCCN
Show InChI InChI=1S/C14H18ClN5O/c1-21-12-9-18-14(20-13(12)17-8-2-7-16)19-11-5-3-10(15)4-6-11/h3-6,9H,2,7-8,16H2,1H3,(H2,17,18,19,20)
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n/an/a 870n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens (Human))
BDBM441902
PNG
(US10647686, Comparative Example 4)
Show SMILES NCCCNc1ccnc(Nc2ccc(Cl)cc2)n1
Show InChI InChI=1S/C13H16ClN5/c14-10-2-4-11(5-3-10)18-13-17-9-6-12(19-13)16-8-1-7-15/h2-6,9H,1,7-8,15H2,(H2,16,17,18,19)
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n/an/a 1.10E+3n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens (Human))
BDBM441889
PNG
(US10647686, Example (32))
Show SMILES Cc1cnc(Nc2ccc(Br)c(c2)C(F)(F)F)nc1NCCCN
Show InChI InChI=1S/C15H17BrF3N5/c1-9-8-22-14(24-13(9)21-6-2-5-20)23-10-3-4-12(16)11(7-10)15(17,18)19/h3-4,7-8H,2,5-6,20H2,1H3,(H2,21,22,23,24)
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n/an/a 1.40E+3n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B (STK17B)


(Homo sapiens (Human))
BDBM441865
PNG
(US10647686, Example (12))
Show SMILES CCCCCCc1ccc(Nc2ncc(Cl)c(NCCCN)n2)cc1
Show InChI InChI=1S/C19H28ClN5/c1-2-3-4-5-7-15-8-10-16(11-9-15)24-19-23-14-17(20)18(25-19)22-13-6-12-21/h8-11,14H,2-7,12-13,21H2,1H3,(H2,22,23,24,25)
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n/an/a 1.90E+3n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%