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Patent code US10647708

Compile Data Set for Download or QSAR
Found 46 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM442057
PNG
(24(1-acetylpiperidin-4-yl)amino)-N-(4-(3,4-dihydro...)
Show SMILES CC(=O)N1CCC(CC1)Nc1cc(ccn1)C(=O)NCCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C26H35N5O3/c1-19(32)31-14-9-23(10-15-31)29-25-16-21(6-11-27-25)26(34)28-12-7-24(33)18-30-13-8-20-4-2-3-5-22(20)17-30/h2-6,11,16,23-24,33H,7-10,12-15,17-18H2,1H3,(H,27,29)(H,28,34)
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n/an/a 186n/an/an/an/an/an/a



CTXT PTY. LTD

US Patent


Assay Description
Full-length PRMT5 enzyme (NCBI Reference sequence NP_006100.2) was co-expressed with Hiss-MEP50 in insect cells and purified via Nickel immobilized m...


US Patent US10647708 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM442031
PNG
(US10647708, Compound 20)
Show SMILES OC(CCNC(=O)c1ccc(cc1)S(F)(F)(F)(F)F)CN1CCc2ccccc2C1
Show InChI InChI=1S/C20H23F5N2O2S/c21-30(22,23,24,25)19-7-5-16(6-8-19)20(29)26-11-9-18(28)14-27-12-10-15-3-1-2-4-17(15)13-27/h1-8,18,28H,9-14H2,(H,26,29)
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n/an/a 214n/an/an/an/an/an/a



CTXT PTY. LTD

US Patent


Assay Description
Full-length PRMT5 enzyme (NCBI Reference sequence NP_006100.2) was co-expressed with Hiss-MEP50 in insect cells and purified via Nickel immobilized m...


US Patent US10647708 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM442030
PNG
(US10647708, Compound 19)
Show SMILES OC(CCNC(=O)c1ccc(OC(F)(F)F)cc1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C21H23F3N2O3/c22-21(23,24)29-19-7-5-16(6-8-19)20(28)25-11-9-18(27)14-26-12-10-15-3-1-2-4-17(15)13-26/h1-8,18,27H,9-14H2,(H,25,28)
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US Patent


Assay Description
Full-length PRMT5 enzyme (NCBI Reference sequence NP_006100.2) was co-expressed with Hiss-MEP50 in insect cells and purified via Nickel immobilized m...


US Patent US10647708 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM441959
PNG
(4-Chloro-N-(4-(3,4-dihydroisoquinolin-2(1H)-yl)-3-...)
Show SMILES OC(CCNC(=O)c1ccc(Cl)cc1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C20H23ClN2O2/c21-18-7-5-16(6-8-18)20(25)22-11-9-19(24)14-23-12-10-15-3-1-2-4-17(15)13-23/h1-8,19,24H,9-14H2,(H,22,25)
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Assay Description
The κ uL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sa...


US Patent US10647708 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM442032
PNG
(US10647708, Compound 21)
Show SMILES OC(CCNC(=O)c1ccc(O[H]C(F)F)cc1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C21H25F2N2O3/c22-21(23)29-28-19-7-5-16(6-8-19)20(27)24-11-9-18(26)14-25-12-10-15-3-1-2-4-17(15)13-25/h1-8,18,21,26H,9-14H2,(H,24,27)
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n/an/a 415n/an/an/an/an/an/a



CTXT PTY. LTD

US Patent


Assay Description
Full-length PRMT5 enzyme (NCBI Reference sequence NP_006100.2) was co-expressed with Hiss-MEP50 in insect cells and purified via Nickel immobilized m...


US Patent US10647708 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM442051
PNG
(US10647708, Compound 40)
Show SMILES OC(CCNC(=O)c1ccc(cc1)-c1ccccc1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C26H28N2O2/c29-25(19-28-17-15-21-8-4-5-9-24(21)18-28)14-16-27-26(30)23-12-10-22(11-13-23)20-6-2-1-3-7-20/h1-13,25,29H,14-19H2,(H,27,30)
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n/an/a 769n/an/an/an/an/an/a



CTXT PTY. LTD

US Patent


Assay Description
Full-length PRMT5 enzyme (NCBI Reference sequence NP_006100.2) was co-expressed with Hiss-MEP50 in insect cells and purified via Nickel immobilized m...


US Patent US10647708 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM442024
PNG
(US10647708, Compound 14)
Show SMILES OC(CCNC(=O)c1ccc(nc1)N1CCOCC1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C23H30N4O3/c28-21(17-26-10-8-18-3-1-2-4-20(18)16-26)7-9-24-23(29)19-5-6-22(25-15-19)27-11-13-30-14-12-27/h1-6,15,21,28H,7-14,16-17H2,(H,24,29)
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n/an/a 910n/an/an/an/an/an/a



CTXT PTY. LTD

US Patent


Assay Description
Full-length PRMT5 enzyme (NCBI Reference sequence NP_006100.2) was co-expressed with Hiss-MEP50 in insect cells and purified via Nickel immobilized m...


US Patent US10647708 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM442012
PNG
(US10647708, Compound 3)
Show SMILES OC(CCNC(=O)c1ccc(cc1)S(=O)C(F)(F)F)CN1CCc2ccccc2C1
Show InChI InChI=1S/C21H23F3N2O3S/c22-21(23,24)30(29)19-7-5-16(6-8-19)20(28)25-11-9-18(27)14-26-12-10-15-3-1-2-4-17(15)13-26/h1-8,18,27H,9-14H2,(H,25,28)
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n/an/a 925n/an/an/an/an/an/a



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US Patent


Assay Description
Full-length PRMT5 enzyme (NCBI Reference sequence NP_006100.2) was co-expressed with Hiss-MEP50 in insect cells and purified via Nickel immobilized m...


US Patent US10647708 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM442011
PNG
(US10647708, Compound 2)
Show SMILES OC(CCNC(=O)c1ccc(cc1)S(=O)(=O)C(F)(F)F)CN1CCc2ccccc2C1
Show InChI InChI=1S/C21H23F3N2O4S/c22-21(23,24)31(29,30)19-7-5-16(6-8-19)20(28)25-11-9-18(27)14-26-12-10-15-3-1-2-4-17(15)13-26/h1-8,18,27H,9-14H2,(H,25,28)
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n/an/a 1.13E+3n/an/an/an/an/an/a



CTXT PTY. LTD

US Patent


Assay Description
Full-length PRMT5 enzyme (NCBI Reference sequence NP_006100.2) was co-expressed with Hiss-MEP50 in insect cells and purified via Nickel immobilized m...


US Patent US10647708 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM442048
PNG
(US10647708, Compound 37)
Show SMILES Cn1cc(cn1)-c1cc(no1)C(=O)NCCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C21H25N5O3/c1-25-12-17(11-23-25)20-10-19(24-29-20)21(28)22-8-6-18(27)14-26-9-7-15-4-2-3-5-16(15)13-26/h2-5,10-12,18,27H,6-9,13-14H2,1H3,(H,22,28)
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n/an/a 1.19E+3n/an/an/an/an/an/a



CTXT PTY. LTD

US Patent


Assay Description
Full-length PRMT5 enzyme (NCBI Reference sequence NP_006100.2) was co-expressed with Hiss-MEP50 in insect cells and purified via Nickel immobilized m...


US Patent US10647708 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM442047
PNG
(US10647708, Compound 36)
Show SMILES Cc1nn(C)cc1-c1cc(no1)C(=O)NCCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C22H27N5O3/c1-15-19(14-26(2)24-15)21-11-20(25-30-21)22(29)23-9-7-18(28)13-27-10-8-16-5-3-4-6-17(16)12-27/h3-6,11,14,18,28H,7-10,12-13H2,1-2H3,(H,23,29)
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n/an/a 1.20E+3n/an/an/an/an/an/a



CTXT PTY. LTD

US Patent


Assay Description
Full-length PRMT5 enzyme (NCBI Reference sequence NP_006100.2) was co-expressed with Hiss-MEP50 in insect cells and purified via Nickel immobilized m...


US Patent US10647708 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM442046
PNG
(US10647708, Compound 35)
Show SMILES OC(CCNC(=O)c1coc(n1)-c1ccccc1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C23H25N3O3/c27-20(15-26-13-11-17-6-4-5-9-19(17)14-26)10-12-24-22(28)21-16-29-23(25-21)18-7-2-1-3-8-18/h1-9,16,20,27H,10-15H2,(H,24,28)
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n/an/a 1.21E+3n/an/an/an/an/an/a



CTXT PTY. LTD

US Patent


Assay Description
Full-length PRMT5 enzyme (NCBI Reference sequence NP_006100.2) was co-expressed with Hiss-MEP50 in insect cells and purified via Nickel immobilized m...


US Patent US10647708 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM442050
PNG
(US10647708, Compound 39)
Show SMILES Cc1nnc(o1)-c1cccc(c1)C(=O)NCCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C23H26N4O3/c1-16-25-26-23(30-16)19-8-4-7-18(13-19)22(29)24-11-9-21(28)15-27-12-10-17-5-2-3-6-20(17)14-27/h2-8,13,21,28H,9-12,14-15H2,1H3,(H,24,29)
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n/an/a 1.22E+3n/an/an/an/an/an/a



CTXT PTY. LTD

US Patent


Assay Description
Full-length PRMT5 enzyme (NCBI Reference sequence NP_006100.2) was co-expressed with Hiss-MEP50 in insect cells and purified via Nickel immobilized m...


US Patent US10647708 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM442014
PNG
(US10647708, Compound 5)
Show SMILES OC(CCNC(=O)c1ccc(cc1)C(F)(F)F)CN1CCc2ccccc2C1
Show InChI InChI=1S/C21H23F3N2O2/c22-21(23,24)18-7-5-16(6-8-18)20(28)25-11-9-19(27)14-26-12-10-15-3-1-2-4-17(15)13-26/h1-8,19,27H,9-14H2,(H,25,28)
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n/an/a 1.33E+3n/an/an/an/an/an/a



CTXT PTY. LTD

US Patent


Assay Description
Full-length PRMT5 enzyme (NCBI Reference sequence NP_006100.2) was co-expressed with Hiss-MEP50 in insect cells and purified via Nickel immobilized m...


US Patent US10647708 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM442022
PNG
(US10647708, Compound 12)
Show SMILES OC(CCNC(=O)c1ccn(Cc2ccccc2)c(=O)c1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C26H29N3O3/c30-24(19-28-14-11-21-8-4-5-9-23(21)18-28)10-13-27-26(32)22-12-15-29(25(31)16-22)17-20-6-2-1-3-7-20/h1-9,12,15-16,24,30H,10-11,13-14,17-19H2,(H,27,32)
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n/an/a 1.60E+3n/an/an/an/an/an/a



CTXT PTY. LTD

US Patent


Assay Description
Full-length PRMT5 enzyme (NCBI Reference sequence NP_006100.2) was co-expressed with Hiss-MEP50 in insect cells and purified via Nickel immobilized m...


US Patent US10647708 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM442034
PNG
(US10647708, Compound 23)
Show SMILES OC(CCNC(=O)c1ccc2OC(F)(F)Oc2c1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C21H22F2N2O4/c22-21(23)28-18-6-5-15(11-19(18)29-21)20(27)24-9-7-17(26)13-25-10-8-14-3-1-2-4-16(14)12-25/h1-6,11,17,26H,7-10,12-13H2,(H,24,27)
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n/an/a 1.69E+3n/an/an/an/an/an/a



CTXT PTY. LTD

US Patent


Assay Description
Full-length PRMT5 enzyme (NCBI Reference sequence NP_006100.2) was co-expressed with Hiss-MEP50 in insect cells and purified via Nickel immobilized m...


US Patent US10647708 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM442017
PNG
(US10647708, Compound 7)
Show SMILES COc1ccc(cc1)-n1cc(cn1)C(=O)NCCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C24H28N4O3/c1-31-23-8-6-21(7-9-23)28-16-20(14-26-28)24(30)25-12-10-22(29)17-27-13-11-18-4-2-3-5-19(18)15-27/h2-9,14,16,22,29H,10-13,15,17H2,1H3,(H,25,30)
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n/an/a 1.94E+3n/an/an/an/an/an/a



CTXT PTY. LTD

US Patent


Assay Description
Full-length PRMT5 enzyme (NCBI Reference sequence NP_006100.2) was co-expressed with Hiss-MEP50 in insect cells and purified via Nickel immobilized m...


US Patent US10647708 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM442053
PNG
(US10647708, Compound 42)
Show SMILES Cc1nnc(o1)-c1ccc(cc1)C(=O)NCCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C23H26N4O3/c1-16-25-26-23(30-16)19-8-6-18(7-9-19)22(29)24-12-10-21(28)15-27-13-11-17-4-2-3-5-20(17)14-27/h2-9,21,28H,10-15H2,1H3,(H,24,29)
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n/an/a 2.83E+3n/an/an/an/an/an/a



CTXT PTY. LTD

US Patent


Assay Description
Full-length PRMT5 enzyme (NCBI Reference sequence NP_006100.2) was co-expressed with Hiss-MEP50 in insect cells and purified via Nickel immobilized m...


US Patent US10647708 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM442049
PNG
(US10647708, Compound 38)
Show SMILES OC(CCNC(=O)c1ccnn1-c1cccnc1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C22H25N5O2/c28-20(16-26-13-9-17-4-1-2-5-18(17)15-26)7-11-24-22(29)21-8-12-25-27(21)19-6-3-10-23-14-19/h1-6,8,10,12,14,20,28H,7,9,11,13,15-16H2,(H,24,29)
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n/an/a 2.88E+3n/an/an/an/an/an/a



CTXT PTY. LTD

US Patent


Assay Description
Full-length PRMT5 enzyme (NCBI Reference sequence NP_006100.2) was co-expressed with Hiss-MEP50 in insect cells and purified via Nickel immobilized m...


US Patent US10647708 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM442018
PNG
(US10647708, Compound 8)
Show SMILES COc1ccc(cc1)-c1cc(on1)C(=O)NCCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C24H27N3O4/c1-30-21-8-6-18(7-9-21)22-14-23(31-26-22)24(29)25-12-10-20(28)16-27-13-11-17-4-2-3-5-19(17)15-27/h2-9,14,20,28H,10-13,15-16H2,1H3,(H,25,29)
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n/an/a 3.09E+3n/an/an/an/an/an/a



CTXT PTY. LTD

US Patent


Assay Description
Full-length PRMT5 enzyme (NCBI Reference sequence NP_006100.2) was co-expressed with Hiss-MEP50 in insect cells and purified via Nickel immobilized m...


US Patent US10647708 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM442041
PNG
(US10647708, Compound 30)
Show SMILES OC(CCNC(=O)c1ccc(cc1)C(=O)N1CCCC1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C25H31N3O3/c29-23(18-27-16-12-19-5-1-2-6-22(19)17-27)11-13-26-24(30)20-7-9-21(10-8-20)25(31)28-14-3-4-15-28/h1-2,5-10,23,29H,3-4,11-18H2,(H,26,30)
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n/an/a 3.12E+3n/an/an/an/an/an/a



CTXT PTY. LTD

US Patent


Assay Description
Full-length PRMT5 enzyme (NCBI Reference sequence NP_006100.2) was co-expressed with Hiss-MEP50 in insect cells and purified via Nickel immobilized m...


US Patent US10647708 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM442042
PNG
(US10647708, Compound 31)
Show SMILES OC(CCNC(=O)c1ccc(cc1)C(=O)N1CCC1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C24H29N3O3/c28-22(17-26-15-11-18-4-1-2-5-21(18)16-26)10-12-25-23(29)19-6-8-20(9-7-19)24(30)27-13-3-14-27/h1-2,4-9,22,28H,3,10-17H2,(H,25,29)
PDB

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n/an/a 3.16E+3n/an/an/an/an/an/a



CTXT PTY. LTD

US Patent


Assay Description
Full-length PRMT5 enzyme (NCBI Reference sequence NP_006100.2) was co-expressed with Hiss-MEP50 in insect cells and purified via Nickel immobilized m...


US Patent US10647708 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM442043
PNG
(US10647708, Compound 32)
Show SMILES CN(C)C(=O)c1ccc(cc1)C(=O)NCCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C23H29N3O3/c1-25(2)23(29)19-9-7-18(8-10-19)22(28)24-13-11-21(27)16-26-14-12-17-5-3-4-6-20(17)15-26/h3-10,21,27H,11-16H2,1-2H3,(H,24,28)
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n/an/a 3.54E+3n/an/an/an/an/an/a



CTXT PTY. LTD

US Patent


Assay Description
Full-length PRMT5 enzyme (NCBI Reference sequence NP_006100.2) was co-expressed with Hiss-MEP50 in insect cells and purified via Nickel immobilized m...


US Patent US10647708 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM442037
PNG
(US10647708, Compound 26)
Show SMILES CS(=O)c1ccc(cc1)C(=O)NCCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C21H26N2O3S/c1-27(26)20-8-6-17(7-9-20)21(25)22-12-10-19(24)15-23-13-11-16-4-2-3-5-18(16)14-23/h2-9,19,24H,10-15H2,1H3,(H,22,25)
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n/an/a 3.75E+3n/an/an/an/an/an/a



CTXT PTY. LTD

US Patent


Assay Description
Full-length PRMT5 enzyme (NCBI Reference sequence NP_006100.2) was co-expressed with Hiss-MEP50 in insect cells and purified via Nickel immobilized m...


US Patent US10647708 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM442026
PNG
(US10647708, Compound 15)
Show SMILES OC(CCNC(=O)c1ccc(cc1)C#N)CN1CCc2ccccc2C1
Show InChI InChI=1S/C21H23N3O2/c22-13-16-5-7-18(8-6-16)21(26)23-11-9-20(25)15-24-12-10-17-3-1-2-4-19(17)14-24/h1-8,20,25H,9-12,14-15H2,(H,23,26)
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n/an/a 3.98E+3n/an/an/an/an/an/a



CTXT PTY. LTD

US Patent


Assay Description
Full-length PRMT5 enzyme (NCBI Reference sequence NP_006100.2) was co-expressed with Hiss-MEP50 in insect cells and purified via Nickel immobilized m...


US Patent US10647708 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM442020
PNG
(US10647708, Compound 10)
Show SMILES Cc1nonc1COc1ccc(cc1)C(=O)NCCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C24H28N4O4/c1-17-23(27-32-26-17)16-31-22-8-6-19(7-9-22)24(30)25-12-10-21(29)15-28-13-11-18-4-2-3-5-20(18)14-28/h2-9,21,29H,10-16H2,1H3,(H,25,30)
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n/an/a 3.98E+3n/an/an/an/an/an/a



CTXT PTY. LTD

US Patent


Assay Description
Full-length PRMT5 enzyme (NCBI Reference sequence NP_006100.2) was co-expressed with Hiss-MEP50 in insect cells and purified via Nickel immobilized m...


US Patent US10647708 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM442019
PNG
(US10647708, Compound 9)
Show SMILES OC(CCNC(=O)c1ccc2oc(=O)[nH]c2c1)CN1CCc2ccccc2C1
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n/an/a 4.35E+3n/an/an/an/an/an/a



CTXT PTY. LTD

US Patent


Assay Description
Full-length PRMT5 enzyme (NCBI Reference sequence NP_006100.2) was co-expressed with Hiss-MEP50 in insect cells and purified via Nickel immobilized m...


US Patent US10647708 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM442056
PNG
(N-(4-(3,4-dihydroisoquinolin-2(1H)-yl)-3-hydroxybu...)
Show SMILES OC(CCNC(=O)c1cccc(c1)C(=O)N1CCOCC1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C25H31N3O4/c29-23(18-27-11-9-19-4-1-2-5-22(19)17-27)8-10-26-24(30)20-6-3-7-21(16-20)25(31)28-12-14-32-15-13-28/h1-7,16,23,29H,8-15,17-18H2,(H,26,30)
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n/an/a 5.23E+3n/an/an/an/an/an/a



CTXT PTY. LTD

US Patent


Assay Description
Full-length PRMT5 enzyme (NCBI Reference sequence NP_006100.2) was co-expressed with Hiss-MEP50 in insect cells and purified via Nickel immobilized m...


US Patent US10647708 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM442052
PNG
(US10647708, Compound 41)
Show SMILES OC(CCNC(=O)c1cccc(c1)-c1ccccc1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C26H28N2O2/c29-25(19-28-16-14-21-9-4-5-10-24(21)18-28)13-15-27-26(30)23-12-6-11-22(17-23)20-7-2-1-3-8-20/h1-12,17,25,29H,13-16,18-19H2,(H,27,30)
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n/an/a 5.29E+3n/an/an/an/an/an/a



CTXT PTY. LTD

US Patent


Assay Description
Full-length PRMT5 enzyme (NCBI Reference sequence NP_006100.2) was co-expressed with Hiss-MEP50 in insect cells and purified via Nickel immobilized m...


US Patent US10647708 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM442038
PNG
(US10647708, Compound 27)
Show SMILES COc1ccc(cc1-c1cncnc1)C(=O)NCCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C25H28N4O3/c1-32-24-7-6-19(12-23(24)21-13-26-17-27-14-21)25(31)28-10-8-22(30)16-29-11-9-18-4-2-3-5-20(18)15-29/h2-7,12-14,17,22,30H,8-11,15-16H2,1H3,(H,28,31)
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n/an/a 5.62E+3n/an/an/an/an/an/a



CTXT PTY. LTD

US Patent


Assay Description
Full-length PRMT5 enzyme (NCBI Reference sequence NP_006100.2) was co-expressed with Hiss-MEP50 in insect cells and purified via Nickel immobilized m...


US Patent US10647708 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM442036
PNG
(US10647708, Compound 25)
Show SMILES OC(CCNC(=O)c1cccc(c1)-c1ccnnc1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C24H26N4O2/c29-23(17-28-13-10-18-4-1-2-5-22(18)16-28)9-11-25-24(30)20-7-3-6-19(14-20)21-8-12-26-27-15-21/h1-8,12,14-15,23,29H,9-11,13,16-17H2,(H,25,30)
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n/an/a 6.35E+3n/an/an/an/an/an/a



CTXT PTY. LTD

US Patent


Assay Description
Full-length PRMT5 enzyme (NCBI Reference sequence NP_006100.2) was co-expressed with Hiss-MEP50 in insect cells and purified via Nickel immobilized m...


US Patent US10647708 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM442033
PNG
(US10647708, Compound 22)
Show SMILES CS(=O)(=O)c1ccc(cc1)C(=O)NCCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C21H26N2O4S/c1-28(26,27)20-8-6-17(7-9-20)21(25)22-12-10-19(24)15-23-13-11-16-4-2-3-5-18(16)14-23/h2-9,19,24H,10-15H2,1H3,(H,22,25)
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n/an/a 7.02E+3n/an/an/an/an/an/a



CTXT PTY. LTD

US Patent


Assay Description
Full-length PRMT5 enzyme (NCBI Reference sequence NP_006100.2) was co-expressed with Hiss-MEP50 in insect cells and purified via Nickel immobilized m...


US Patent US10647708 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM442023
PNG
(US10647708, Compound 13)
Show SMILES Cc1c(cnn1-c1ccncc1)C(=O)NCCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C23H27N5O2/c1-17-22(14-26-28(17)20-6-10-24-11-7-20)23(30)25-12-8-21(29)16-27-13-9-18-4-2-3-5-19(18)15-27/h2-7,10-11,14,21,29H,8-9,12-13,15-16H2,1H3,(H,25,30)
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n/an/a 7.09E+3n/an/an/an/an/an/a



CTXT PTY. LTD

US Patent


Assay Description
Full-length PRMT5 enzyme (NCBI Reference sequence NP_006100.2) was co-expressed with Hiss-MEP50 in insect cells and purified via Nickel immobilized m...


US Patent US10647708 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM442044
PNG
(US10647708, Compound 33)
Show SMILES Cc1c(cnn1-c1ccccn1)C(=O)NCCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C23H27N5O2/c1-17-21(14-26-28(17)22-8-4-5-11-24-22)23(30)25-12-9-20(29)16-27-13-10-18-6-2-3-7-19(18)15-27/h2-8,11,14,20,29H,9-10,12-13,15-16H2,1H3,(H,25,30)
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n/an/a 7.45E+3n/an/an/an/an/an/a



CTXT PTY. LTD

US Patent


Assay Description
Full-length PRMT5 enzyme (NCBI Reference sequence NP_006100.2) was co-expressed with Hiss-MEP50 in insect cells and purified via Nickel immobilized m...


US Patent US10647708 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM442029
PNG
(US10647708, Compound 18)
Show SMILES OC(CCNC(=O)c1cccc(Cl)c1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C20H23ClN2O2/c21-18-7-3-6-16(12-18)20(25)22-10-8-19(24)14-23-11-9-15-4-1-2-5-17(15)13-23/h1-7,12,19,24H,8-11,13-14H2,(H,22,25)
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n/an/a 9.79E+3n/an/an/an/an/an/a



CTXT PTY. LTD

US Patent


Assay Description
Full-length PRMT5 enzyme (NCBI Reference sequence NP_006100.2) was co-expressed with Hiss-MEP50 in insect cells and purified via Nickel immobilized m...


US Patent US10647708 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM442040
PNG
(US10647708, Compound 29)
Show SMILES Cn1ccc(cc1=O)C(=O)NCCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C20H25N3O3/c1-22-10-7-16(12-19(22)25)20(26)21-9-6-18(24)14-23-11-8-15-4-2-3-5-17(15)13-23/h2-5,7,10,12,18,24H,6,8-9,11,13-14H2,1H3,(H,21,26)
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n/an/a 1.08E+4n/an/an/an/an/an/a



CTXT PTY. LTD

US Patent


Assay Description
Full-length PRMT5 enzyme (NCBI Reference sequence NP_006100.2) was co-expressed with Hiss-MEP50 in insect cells and purified via Nickel immobilized m...


US Patent US10647708 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM442039
PNG
(US10647708, Compound 28)
Show SMILES OC(CCNC(=O)c1cnn(c1)-c1ccccn1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C22H25N5O2/c28-20(16-26-12-9-17-5-1-2-6-18(17)14-26)8-11-24-22(29)19-13-25-27(15-19)21-7-3-4-10-23-21/h1-7,10,13,15,20,28H,8-9,11-12,14,16H2,(H,24,29)
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n/an/a 1.23E+4n/an/an/an/an/an/a



CTXT PTY. LTD

US Patent


Assay Description
Full-length PRMT5 enzyme (NCBI Reference sequence NP_006100.2) was co-expressed with Hiss-MEP50 in insect cells and purified via Nickel immobilized m...


US Patent US10647708 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM442027
PNG
(US10647708, Compound 16)
Show SMILES OC(CCNC(=O)c1cccc(c1)C#N)CN1CCc2ccccc2C1
Show InChI InChI=1S/C21H23N3O2/c22-13-16-4-3-7-18(12-16)21(26)23-10-8-20(25)15-24-11-9-17-5-1-2-6-19(17)14-24/h1-7,12,20,25H,8-11,14-15H2,(H,23,26)
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n/an/a 1.30E+4n/an/an/an/an/an/a



CTXT PTY. LTD

US Patent


Assay Description
Full-length PRMT5 enzyme (NCBI Reference sequence NP_006100.2) was co-expressed with Hiss-MEP50 in insect cells and purified via Nickel immobilized m...


US Patent US10647708 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM442015
PNG
(US10647708, Compound 6)
Show SMILES OC(CCNC(=O)c1ccc(cc1)N1CCCCC1=O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C25H31N3O3/c29-23(18-27-16-13-19-5-1-2-6-21(19)17-27)12-14-26-25(31)20-8-10-22(11-9-20)28-15-4-3-7-24(28)30/h1-2,5-6,8-11,23,29H,3-4,7,12-18H2,(H,26,31)
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n/an/a 1.31E+4n/an/an/an/an/an/a



CTXT PTY. LTD

US Patent


Assay Description
Full-length PRMT5 enzyme (NCBI Reference sequence NP_006100.2) was co-expressed with Hiss-MEP50 in insect cells and purified via Nickel immobilized m...


US Patent US10647708 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM442055
PNG
(2-Chloro-N-(4-(3,4-dihydroisoquinolin-2(1H)-yl)-3-...)
Show SMILES OC(CCNC(=O)c1ccnc(Cl)c1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C19H22ClN3O2/c20-18-11-15(5-8-21-18)19(25)22-9-6-17(24)13-23-10-7-14-3-1-2-4-16(14)12-23/h1-5,8,11,17,24H,6-7,9-10,12-13H2,(H,22,25)
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n/an/a 1.37E+4n/an/an/an/an/an/a



CTXT PTY. LTD

US Patent


Assay Description
Full-length PRMT5 enzyme (NCBI Reference sequence NP_006100.2) was co-expressed with Hiss-MEP50 in insect cells and purified via Nickel immobilized m...


US Patent US10647708 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM442028
PNG
(US10647708, Compound 17)
Show SMILES OC(CCNC(=O)c1cccnc1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C19H23N3O2/c23-18(7-10-21-19(24)16-6-3-9-20-12-16)14-22-11-8-15-4-1-2-5-17(15)13-22/h1-6,9,12,18,23H,7-8,10-11,13-14H2,(H,21,24)
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n/an/a 1.50E+4n/an/an/an/an/an/a



CTXT PTY. LTD

US Patent


Assay Description
Full-length PRMT5 enzyme (NCBI Reference sequence NP_006100.2) was co-expressed with Hiss-MEP50 in insect cells and purified via Nickel immobilized m...


US Patent US10647708 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM442035
PNG
(US10647708, Compound 24)
Show SMILES Cc1cccc(n1)C(=O)NCCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C20H25N3O2/c1-15-5-4-8-19(22-15)20(25)21-11-9-18(24)14-23-12-10-16-6-2-3-7-17(16)13-23/h2-8,18,24H,9-14H2,1H3,(H,21,25)
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n/an/a 2.54E+4n/an/an/an/an/an/a



CTXT PTY. LTD

US Patent


Assay Description
Full-length PRMT5 enzyme (NCBI Reference sequence NP_006100.2) was co-expressed with Hiss-MEP50 in insect cells and purified via Nickel immobilized m...


US Patent US10647708 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM442021
PNG
(US10647708, Compound 11)
Show SMILES OC(CCNC(=O)c1nnc(o1)-c1ccccc1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C22H24N4O3/c27-19(15-26-13-11-16-6-4-5-9-18(16)14-26)10-12-23-20(28)22-25-24-21(29-22)17-7-2-1-3-8-17/h1-9,19,27H,10-15H2,(H,23,28)
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n/an/a 3.92E+4n/an/an/an/an/an/a



CTXT PTY. LTD

US Patent


Assay Description
Full-length PRMT5 enzyme (NCBI Reference sequence NP_006100.2) was co-expressed with Hiss-MEP50 in insect cells and purified via Nickel immobilized m...


US Patent US10647708 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM442013
PNG
(US10647708, Compound 4)
Show SMILES CS(=O)(=O)c1ccccc1OCC(=O)NCCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C22H28N2O5S/c1-30(27,28)21-9-5-4-8-20(21)29-16-22(26)23-12-10-19(25)15-24-13-11-17-6-2-3-7-18(17)14-24/h2-9,19,25H,10-16H2,1H3,(H,23,26)
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n/an/a 5.17E+4n/an/an/an/an/an/a



CTXT PTY. LTD

US Patent


Assay Description
Full-length PRMT5 enzyme (NCBI Reference sequence NP_006100.2) was co-expressed with Hiss-MEP50 in insect cells and purified via Nickel immobilized m...


US Patent US10647708 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM442045
PNG
(US10647708, Compound 34)
Show SMILES OC(CCNC(=O)c1noc(n1)-c1ccccc1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C22H24N4O3/c27-19(15-26-13-11-16-6-4-5-9-18(16)14-26)10-12-23-21(28)20-24-22(29-25-20)17-7-2-1-3-8-17/h1-9,19,27H,10-15H2,(H,23,28)
PDB

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n/an/a 5.61E+4n/an/an/an/an/an/a



CTXT PTY. LTD

US Patent


Assay Description
Full-length PRMT5 enzyme (NCBI Reference sequence NP_006100.2) was co-expressed with Hiss-MEP50 in insect cells and purified via Nickel immobilized m...


US Patent US10647708 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM442054
PNG
(US10647708, Compound 43)
Show SMILES OC(CCNC(=O)c1cncc(Cl)n1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C18H21ClN4O2/c19-17-10-20-9-16(22-17)18(25)21-7-5-15(24)12-23-8-6-13-3-1-2-4-14(13)11-23/h1-4,9-10,15,24H,5-8,11-12H2,(H,21,25)
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n/an/a 1.06E+5n/an/an/an/an/an/a



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Assay Description
Full-length PRMT5 enzyme (NCBI Reference sequence NP_006100.2) was co-expressed with Hiss-MEP50 in insect cells and purified via Nickel immobilized m...


US Patent US10647708 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%