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Patent code US10647713

Compile Data Set for Download or QSAR

Found 620 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Non-receptor tyrosine-protein kinase TYK2 (aa 556-888)


(Homo sapiens (Human))		BDBM442541
PNG
(US10647713, Compound I-502)
Show SMILES COCCCn1ccc(n1)-c1ccc(Nc2cc(NC(=O)C3CC3)nc3[nH]c(C)nc23)c(c1)S(C)(=O)=O
Show InChI InChI=1S/C25H29N7O4S/c1-15-26-23-20(14-22(29-24(23)27-15)30-25(33)16-5-6-16)28-19-8-7-17(13-21(19)37(3,34)35)18-9-11-32(31-18)10-4-12-36-2/h7-9,11,13-14,16H,4-6,10,12H2,1-3H3,(H3,26,27,28,29,30,33)
GoogleScholar
UniChem
US Patent
n/an/an/a 0.300n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10647713 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (aa 556-888)


(Homo sapiens (Human))		BDBM442644
PNG
(US10647713, Compound I-606)
Show SMILES COc1c(Nc2cc(Nc3cccc(n3)C(F)(F)F)nc3[nH]c(C)nc23)cccc1-c1cnn(C)n1
Show InChI InChI=1S/C23H20F3N9O/c1-12-28-20-15(30-14-7-4-6-13(21(14)36-3)16-11-27-35(2)34-16)10-19(33-22(20)29-12)32-18-9-5-8-17(31-18)23(24,25)26/h4-11H,1-3H3,(H3,28,29,30,31,32,33)
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UniChem
US Patent
n/an/an/a 5.5n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10647713 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (aa 556-888)


(Homo sapiens (Human))		BDBM442657
PNG
(US10647713, Compound I-619)
Show SMILES COCCOc1ccc(Nc2cc(Nc3ccccc3S(C)(=O)=O)c3nc([nH]c3n2)C(F)F)nc1C#N
Show InChI InChI=1S/C23H21F2N7O4S/c1-35-9-10-36-16-7-8-18(28-15(16)12-26)29-19-11-14(20-22(30-19)32-23(31-20)21(24)25)27-13-5-3-4-6-17(13)37(2,33)34/h3-8,11,21H,9-10H2,1-2H3,(H3,27,28,29,30,31,32)
GoogleScholar
UniChem
US Patent
n/an/an/a<0.100n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10647713 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (aa 556-888)


(Homo sapiens (Human))		BDBM442665
PNG
(US10647713, Compound I-627)
Show SMILES COc1c(Nc2cc(Nc3cccc(n3)C(F)(F)F)nc3[nH]c(C)nc23)cccc1-c1ncnn1C
Show InChI InChI=1S/C23H20F3N9O/c1-12-29-19-15(31-14-7-4-6-13(20(14)36-3)22-27-11-28-35(22)2)10-18(34-21(19)30-12)33-17-9-5-8-16(32-17)23(24,25)26/h4-11H,1-3H3,(H3,29,30,31,32,33,34)
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UniChem
US Patent
n/an/an/a 5.5n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10647713 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (aa 556-888)


(Homo sapiens (Human))		BDBM442605
PNG
(US10647713, Compound I-567)
Show SMILES CC1(C)CSC(=N1)c1ccc(Nc2cc(NC(=O)C3CC3)nc3[nH]c(nc23)C(F)F)c(c1)S(C)(=O)=O
Show InChI InChI=1S/C23H24F2N6O3S2/c1-23(2)10-35-22(31-23)12-6-7-13(15(8-12)36(3,33)34)26-14-9-16(28-21(32)11-4-5-11)27-19-17(14)29-20(30-19)18(24)25/h6-9,11,18H,4-5,10H2,1-3H3,(H3,26,27,28,29,30,32)
GoogleScholar
UniChem
US Patent
n/an/an/a 5.5n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10647713 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (aa 556-888)


(Homo sapiens (Human))		BDBM442610
PNG
(US10647713, Compound I-572)
Show SMILES Cc1nc2c(Nc3ccc(cc3S(C)(=O)=O)C3CCC(F)(F)CO3)cc(NC(=O)C3CC3)nc2[nH]1
GoogleScholar
UniChem
US Patent
n/an/an/a 0.300n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10647713 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (aa 556-888)


(Homo sapiens (Human))		BDBM442681
PNG
(US10647713, Compound I-643)
Show SMILES CS(=O)(=O)c1cc(F)ccc1Nc1cc(Nc2ccc3COCCc3n2)nc2[nH]c(nc12)C(F)F
Show InChI InChI=1S/C22H19F3N6O3S/c1-35(32,33)16-8-12(23)3-4-14(16)26-15-9-18(29-21-19(15)30-22(31-21)20(24)25)28-17-5-2-11-10-34-7-6-13(11)27-17/h2-5,8-9,20H,6-7,10H2,1H3,(H3,26,27,28,29,30,31)
GoogleScholar
UniChem
US Patent
n/an/an/a 0.300n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10647713 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (aa 556-888)


(Homo sapiens (Human))		BDBM442686
PNG
(US10647713, Compound I-648)
Show SMILES COc1c(Nc2cc(Nc3cc4CCCc4nn3)nc3[nH]c(nc23)C(F)F)cccc1-c1cnn(C)n1
Show InChI InChI=1S/C24H22F2N10O/c1-36-27-11-17(35-36)13-6-4-8-15(21(13)37-2)28-16-10-18(30-23-20(16)31-24(32-23)22(25)26)29-19-9-12-5-3-7-14(12)33-34-19/h4,6,8-11,22H,3,5,7H2,1-2H3,(H3,28,29,30,31,32,34)
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UniChem
US Patent
n/an/an/a 0.300n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10647713 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (aa 556-888)


(Homo sapiens (Human))		BDBM442621
PNG
(US10647713, Compound I-583)
Show SMILES Cc1nc2c(Nc3ccc(cc3S(C)(=O)=O)-c3cc(C)n(C)n3)cc(Nc3cccc(n3)C#N)nc2[nH]1
Show InChI InChI=1S/C25H23N9O2S/c1-14-10-19(33-34(14)3)16-8-9-18(21(11-16)37(4,35)36)30-20-12-23(32-25-24(20)27-15(2)28-25)31-22-7-5-6-17(13-26)29-22/h5-12H,1-4H3,(H3,27,28,29,30,31,32)
GoogleScholar
UniChem
US Patent
n/an/an/a 0.300n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10647713 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (aa 556-888)


(Homo sapiens (Human))		BDBM442635
PNG
(US10647713, Compound I-597)
Show SMILES Cc1nc2c(Nc3ccccc3S(C)(=O)=O)cc(Nc3cc4CCCc4nn3)nc2[nH]1
Show InChI InChI=1S/C21H21N7O2S/c1-12-22-20-16(24-15-7-3-4-9-17(15)31(2,29)30)11-18(26-21(20)23-12)25-19-10-13-6-5-8-14(13)27-28-19/h3-4,7,9-11H,5-6,8H2,1-2H3,(H3,22,23,24,25,26,28)
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UniChem
US Patent
n/an/an/a 0.300n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10647713 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (aa 556-888)


(Homo sapiens (Human))		BDBM442677
PNG
(US10647713, Compound I-639)
Show SMILES Cc1nc2c(Nc3ccc(F)cc3S(C)(=O)=O)cc(Nc3cc4CCCc4nn3)nc2[nH]1
Show InChI InChI=1S/C21H20FN7O2S/c1-11-23-20-16(25-15-7-6-13(22)9-17(15)32(2,30)31)10-18(27-21(20)24-11)26-19-8-12-4-3-5-14(12)28-29-19/h6-10H,3-5H2,1-2H3,(H3,23,24,25,26,27,29)
GoogleScholar
UniChem
US Patent
n/an/an/a<0.100n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10647713 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (aa 556-888)


(Homo sapiens (Human))		BDBM442189
PNG
(US10647713, Compound I-150)
Show SMILES COCc1ccc(Nc2cc(NC(=O)C3CC3)nc3[nH]c(C)nc23)c(c1)N(C)S(C)(=O)=O
Show InChI InChI=1S/C21H26N6O4S/c1-12-22-19-16(10-18(25-20(19)23-12)26-21(28)14-6-7-14)24-15-8-5-13(11-31-3)9-17(15)27(2)32(4,29)30/h5,8-10,14H,6-7,11H2,1-4H3,(H3,22,23,24,25,26,28)
GoogleScholar
UniChem
US Patent
n/an/an/a 0.300n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10647713 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (aa 556-888)


(Homo sapiens (Human))		BDBM442191
PNG
(US10647713, Compound I-152)
Show SMILES COc1cc(ccc1Nc1cc(Nc2cnc(C)c(C)n2)nc2[nH]c(C)nc12)-c1cncn1C
Show InChI InChI=1S/C24H25N9O/c1-13-14(2)27-22(11-26-13)31-21-9-18(23-24(32-21)29-15(3)28-23)30-17-7-6-16(8-20(17)34-5)19-10-25-12-33(19)4/h6-12H,1-5H3,(H3,27,28,29,30,31,32)
GoogleScholar
UniChem
US Patent
n/an/an/a 5.5n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10647713 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (aa 556-888)


(Homo sapiens (Human))		BDBM442200
PNG
(US10647713, Compound I-161)
Show SMILES COc1cc(ccc1Nc1cc(NC(=O)C2CC2)nc2[nH]c(nc12)C(F)F)-c1nc(C)nn1C
Show InChI InChI=1S/C22H22F2N8O2/c1-10-25-21(32(2)31-10)12-6-7-13(15(8-12)34-3)26-14-9-16(28-22(33)11-4-5-11)27-19-17(14)29-20(30-19)18(23)24/h6-9,11,18H,4-5H2,1-3H3,(H3,26,27,28,29,30,33)
GoogleScholar
UniChem
US Patent
n/an/an/a 5.5n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10647713 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (aa 556-888)


(Homo sapiens (Human))		BDBM442207
PNG
(US10647713, Compound I-168)
Show SMILES COC1CN(C1)c1cnc(Nc2cc(Nc3cccc(-c4nc(C)nn4C)c3OC)c3nc(C)[nH]c3n2)cc1F
Show InChI InChI=1S/C27H29FN10O2/c1-14-30-24-20(33-19-8-6-7-17(25(19)40-5)27-32-15(2)36-37(27)3)10-23(35-26(24)31-14)34-22-9-18(28)21(11-29-22)38-12-16(13-38)39-4/h6-11,16H,12-13H2,1-5H3,(H3,29,30,31,33,34,35)
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UniChem
US Patent
n/an/an/a>10n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10647713 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (aa 556-888)


(Homo sapiens (Human))		BDBM442211
PNG
(US10647713, Compound I-172)
Show SMILES COc1c(Nc2cc(NC(=O)C3CC3)nc3[nH]c(nc23)C(F)(F)F)cccc1-c1nnn(C)n1
Show InChI InChI=1S/C20H18F3N9O2/c1-32-30-16(29-31-32)10-4-3-5-11(15(10)34-2)24-12-8-13(26-18(33)9-6-7-9)25-17-14(12)27-19(28-17)20(21,22)23/h3-5,8-9H,6-7H2,1-2H3,(H3,24,25,26,27,28,33)
GoogleScholar
UniChem
US Patent
n/an/an/a>10n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10647713 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (aa 556-888)


(Homo sapiens (Human))		BDBM442224
PNG
(US10647713, Compound I-185)
Show SMILES Cc1ccc(Nc2cc(Nc3ccc(Cl)cc3S(C)(=O)=O)c3nc([nH]c3n2)C(F)F)nn1
Show InChI InChI=1S/C19H16ClF2N7O2S/c1-9-3-6-14(29-28-9)24-15-8-12(16-18(25-15)27-19(26-16)17(21)22)23-11-5-4-10(20)7-13(11)32(2,30)31/h3-8,17H,1-2H3,(H3,23,24,25,26,27,29)
GoogleScholar
UniChem
US Patent
n/an/an/a 0.300n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10647713 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (aa 556-888)


(Homo sapiens (Human))		BDBM442229
PNG
(US10647713, Compound I-190)
Show SMILES CCS(=O)(=O)N(C)c1ccccc1Nc1cc(Nc2cccc(n2)C#N)nc2[nH]c(nc12)C(F)F
Show InChI InChI=1S/C22H20F2N8O2S/c1-3-35(33,34)32(2)16-9-5-4-8-14(16)27-15-11-18(28-17-10-6-7-13(12-25)26-17)29-21-19(15)30-22(31-21)20(23)24/h4-11,20H,3H2,1-2H3,(H3,26,27,28,29,30,31)
GoogleScholar
UniChem
US Patent
n/an/an/a>10n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10647713 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (aa 556-888)


(Homo sapiens (Human))		BDBM442231
PNG
(US10647713, Compound I-192)
Show SMILES Cc1nc2c(Nc3ccc(Cl)cc3S(C)(=O)=O)cc(NC(=O)[C@H]3C[C@H]3F)nc2[nH]1
GoogleScholar
UniChem
US Patent
n/an/an/a 5.5n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10647713 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (aa 556-888)


(Homo sapiens (Human))		BDBM442065
PNG
(US10647713, Compound I-8)
Show SMILES COc1c(Nc2cc(Nc3ccn(C)n3)nc3[nH]cnc23)cccc1-c1ncn(C)n1
Show InChI InChI=1S/C20H20N10O/c1-29-8-7-15(27-29)25-16-9-14(17-20(26-16)22-10-21-17)24-13-6-4-5-12(18(13)31-3)19-23-11-30(2)28-19/h4-11H,1-3H3,(H3,21,22,24,25,26,27)
GoogleScholar
UniChem
US Patent
n/an/an/a 5.5n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10647713 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (aa 556-888)


(Homo sapiens (Human))		BDBM442066
PNG
(US10647713, Compound I-9)
Show SMILES COc1c(Nc2cc(NC(=O)C3CC3)nc3[nH]c(nc23)C2CC2)cccc1-c1ncn(C)n1
Show InChI InChI=1S/C23H24N8O2/c1-31-11-24-21(30-31)14-4-3-5-15(19(14)33-2)25-16-10-17(27-23(32)13-8-9-13)26-22-18(16)28-20(29-22)12-6-7-12/h3-5,10-13H,6-9H2,1-2H3,(H3,25,26,27,28,29,32)
GoogleScholar
UniChem
US Patent
n/an/an/a>10n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10647713 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (aa 556-888)


(Homo sapiens (Human))		BDBM442080
PNG
(US10647713, Compound I-24)
Show SMILES COc1c(Nc2cc(Nc3cnc(C)c(C)n3)nc3[nH]c(nc23)C(F)F)cccc1-c1ccn(C)n1
Show InChI InChI=1S/C24H23F2N9O/c1-12-13(2)28-19(11-27-12)30-18-10-17(20-23(31-18)33-24(32-20)22(25)26)29-16-7-5-6-14(21(16)36-4)15-8-9-35(3)34-15/h5-11,22H,1-4H3,(H3,28,29,30,31,32,33)
GoogleScholar
UniChem
US Patent
n/an/an/a 5.5n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10647713 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (aa 556-888)


(Homo sapiens (Human))		BDBM442089
PNG
(US10647713, Compound I-33)
Show SMILES COc1c(Nc2cc(Nc3cc(C)cc(n3)C#N)nc3[nH]c(nc23)C(F)F)cccc1-c1ccn(C)n1
Show InChI InChI=1S/C25H21F2N9O/c1-13-9-14(12-28)29-19(10-13)31-20-11-18(21-24(32-20)34-25(33-21)23(26)27)30-17-6-4-5-15(22(17)37-3)16-7-8-36(2)35-16/h4-11,23H,1-3H3,(H3,29,30,31,32,33,34)
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UniChem
US Patent
n/an/an/a 0.75n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10647713 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (aa 556-888)


(Homo sapiens (Human))		BDBM442113
PNG
(US10647713, Compound I-55)
Show SMILES COc1c(Nc2cc(NC(=O)C3CC3)nc3[nH]c(nc23)C(F)F)cccc1-n1ncnc1C
Show InChI InChI=1S/C21H20F2N8O2/c1-10-24-9-25-31(10)14-5-3-4-12(17(14)33-2)26-13-8-15(28-21(32)11-6-7-11)27-19-16(13)29-20(30-19)18(22)23/h3-5,8-9,11,18H,6-7H2,1-2H3,(H3,26,27,28,29,30,32)
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UniChem
US Patent
n/an/an/a>10n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10647713 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (aa 556-888)


(Homo sapiens (Human))		BDBM442247
PNG
(US10647713, Compound I-208)
Show SMILES CN(c1cc(ccc1Nc1cc(NC(=O)[C@@H]2C[C@@H]2F)nc2[nH]c(C)nc12)-c1cncn1C)S(C)(=O)=O
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UniChem
US Patent
n/an/an/a 5.5n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10647713 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (aa 556-888)


(Homo sapiens (Human))		BDBM442262
PNG
(US10647713, Compound I-223)
Show SMILES COCc1ccc(Nc2cc(NC(=O)C3CC3)nc3[nH]c(C)nc23)c(c1)S(C)(=O)=O
Show InChI InChI=1S/C20H23N5O4S/c1-11-21-18-15(9-17(24-19(18)22-11)25-20(26)13-5-6-13)23-14-7-4-12(10-29-2)8-16(14)30(3,27)28/h4,7-9,13H,5-6,10H2,1-3H3,(H3,21,22,23,24,25,26)
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UniChem
US Patent
n/an/an/a 0.300n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10647713 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (aa 556-888)


(Homo sapiens (Human))		BDBM442250
PNG
(US10647713, Compound I-211 | US10647713, Compound ...)
Show SMILES Cc1nc2c(Nc3ccc(cc3S(C)(=O)=O)-c3ccn(C)n3)cc(NC(=O)[C@@H]3C[C@@H]3F)nc2[nH]1
GoogleScholar
UniChem
US Patent
n/an/an/a<0.100n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10647713 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (aa 556-888)


(Homo sapiens (Human))		BDBM442264
PNG
(US10647713, Compound I-225)
Show SMILES Cc1nc2c(Nc3ccc(cc3S(C)(=O)=O)-c3ccn(C)n3)cc(NC(=O)[C@H]3C[C@H]3F)nc2[nH]1
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UniChem
US Patent
n/an/an/a 0.300n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10647713 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (aa 556-888)


(Homo sapiens (Human))		BDBM442268
PNG
(US10647713, Compound I-229)
Show SMILES CS(=O)(=O)N(C(F)F)c1ccccc1Nc1cc(Nc2cccc(n2)C#N)nc2[nH]c(nc12)C(F)F
Show InChI InChI=1S/C21H16F4N8O2S/c1-36(34,35)33(21(24)25)14-7-3-2-6-12(14)28-13-9-16(29-15-8-4-5-11(10-26)27-15)30-19-17(13)31-20(32-19)18(22)23/h2-9,18,21H,1H3,(H3,27,28,29,30,31,32)
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UniChem
US Patent
n/an/an/a 5.5n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10647713 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (aa 556-888)


(Homo sapiens (Human))		BDBM442394
PNG
(US10647713, Compound I-355)
Show SMILES Cc1nc2c(Nc3ccc(cc3S(C)(=O)=O)-c3c(C)nn(C)c3C)cc(Nc3cccc(n3)C#N)nc2[nH]1
Show InChI InChI=1S/C26H25N9O2S/c1-14-24(15(2)35(4)34-14)17-9-10-19(21(11-17)38(5,36)37)31-20-12-23(33-26-25(20)28-16(3)29-26)32-22-8-6-7-18(13-27)30-22/h6-12H,1-5H3,(H3,28,29,30,31,32,33)
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UniChem
US Patent
n/an/an/a 0.300n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10647713 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (aa 556-888)


(Homo sapiens (Human))		BDBM442397
PNG
(US10647713, Compound I-358)
Show SMILES CS(=O)(=O)c1cc(ccc1Nc1cc(NC(=O)C2CC2(F)F)nc2[nH]c(nc12)C(F)F)C1CCC1
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UniChem
US Patent
n/an/an/a>10n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10647713 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (aa 556-888)


(Homo sapiens (Human))		BDBM442405
PNG
(US10647713, Compound I-366)
Show SMILES Cc1cc(Nc2cc(Nc3ccc(cc3S(C)(=O)=O)C3CCCCO3)c3nc([nH]c3n2)C(F)F)nc(C)n1
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UniChem
US Patent
n/an/an/a<0.100n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10647713 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (aa 556-888)


(Homo sapiens (Human))		BDBM442409
PNG
(US10647713, Compound I-370)
Show SMILES CN(c1cc(ccc1Nc1cc(NC(=O)C2C[C@@H]2F)nc2[nH]c(nc12)C(F)F)-c1cncn1C)S(C)(=O)=O
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UniChem
US Patent
n/an/an/a 0.300n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10647713 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (aa 556-888)


(Homo sapiens (Human))		BDBM442431
PNG
(US10647713, Compound I-392)
Show SMILES CS(=O)(=O)c1ccccc1Nc1cc(Nc2cc3CCCc3nn2)nc2[nH]c(nc12)C(F)F
Show InChI InChI=1S/C21H19F2N7O2S/c1-33(31,32)15-8-3-2-6-13(15)24-14-10-16(26-20-18(14)27-21(28-20)19(22)23)25-17-9-11-5-4-7-12(11)29-30-17/h2-3,6,8-10,19H,4-5,7H2,1H3,(H3,24,25,26,27,28,30)
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UniChem
US Patent
n/an/an/a<0.100n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10647713 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (aa 556-888)


(Homo sapiens (Human))		BDBM442116
PNG
(US10647713, Compound I-59)
Show SMILES CN(c1ccccc1Nc1cc(Nc2cnc(C)c(C)n2)nc2[nH]c(nc12)C(F)F)S(C)(=O)=O
Show InChI InChI=1S/C21H22F2N8O2S/c1-11-12(2)25-17(10-24-11)27-16-9-14(18-20(28-16)30-21(29-18)19(22)23)26-13-7-5-6-8-15(13)31(3)34(4,32)33/h5-10,19H,1-4H3,(H3,25,26,27,28,29,30)
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UniChem
US Patent
n/an/an/a 0.300n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10647713 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (aa 556-888)


(Homo sapiens (Human))		BDBM442121
PNG
(US10647713, Compound I-64)
Show SMILES CN(c1cc(ccc1Nc1cc(NC(=O)C2CC2)nc2[nH]c(nc12)C(F)F)-c1cn(C)cn1)S(C)(=O)=O
Show InChI InChI=1S/C23H24F2N8O3S/c1-32-10-16(26-11-32)13-6-7-14(17(8-13)33(2)37(3,35)36)27-15-9-18(29-23(34)12-4-5-12)28-21-19(15)30-22(31-21)20(24)25/h6-12,20H,4-5H2,1-3H3,(H3,27,28,29,30,31,34)
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UniChem
US Patent
n/an/an/a 0.300n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10647713 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (aa 556-888)


(Homo sapiens (Human))		BDBM442130
PNG
(US10647713, Compound I-94)
Show SMILES CN(c1cc(Cl)ccc1Nc1cc(Nc2cccc(n2)C#N)nc2[nH]c(nc12)C(F)F)S(C)(=O)=O
Show InChI InChI=1S/C21H17ClF2N8O2S/c1-32(35(2,33)34)15-8-11(22)6-7-13(15)27-14-9-17(28-16-5-3-4-12(10-25)26-16)29-20-18(14)30-21(31-20)19(23)24/h3-9,19H,1-2H3,(H3,26,27,28,29,30,31)
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UniChem
US Patent
n/an/an/a 0.75n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10647713 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (aa 556-888)


(Homo sapiens (Human))		BDBM442142
PNG
(US10647713, Compound I-107)
Show SMILES COc1c(Nc2cc(NC(=O)C3CC3)nc3[nH]c(C)nc23)cccc1-c1cnn(C)c1
Show InChI InChI=1S/C22H23N7O2/c1-12-24-19-17(9-18(27-21(19)25-12)28-22(30)13-7-8-13)26-16-6-4-5-15(20(16)31-3)14-10-23-29(2)11-14/h4-6,9-11,13H,7-8H2,1-3H3,(H3,24,25,26,27,28,30)
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UniChem
US Patent
n/an/an/a 5.5n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10647713 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (aa 556-888)


(Homo sapiens (Human))		BDBM442148
PNG
(US10647713, Compound I-113)
Show SMILES COc1c(Nc2cc(Nc3ccc(N4CCC4)c(c3)C#N)nc3[nH]c(C)nc23)cccc1-c1nnn(C)n1
Show InChI InChI=1S/C26H25N11O/c1-15-28-23-20(31-19-7-4-6-18(24(19)38-3)25-33-35-36(2)34-25)13-22(32-26(23)29-15)30-17-8-9-21(16(12-17)14-27)37-10-5-11-37/h4,6-9,12-13H,5,10-11H2,1-3H3,(H3,28,29,30,31,32)
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UniChem
US Patent
n/an/an/a 0.300n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10647713 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (aa 556-888)


(Homo sapiens (Human))		BDBM442152
PNG
(US10647713, Compound I-117)
Show SMILES CO[C@@H]1CCN(C1)c1ncc(Nc2cc(Nc3cccc(-c4nnn(C)n4)c3OC)c3nc(C)[nH]c3n2)nc1C#N
GoogleScholar
UniChem
US Patent
n/an/an/a 5.5n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10647713 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (aa 556-888)


(Homo sapiens (Human))		BDBM442153
PNG
(US10647713, Compound I-118)
Show SMILES CN(c1ccccc1Nc1cc(Nc2ccc(C)nn2)nc2[nH]c(C)nc12)S(C)(=O)=O
Show InChI InChI=1S/C20H22N8O2S/c1-12-9-10-17(27-26-12)24-18-11-15(19-20(25-18)22-13(2)21-19)23-14-7-5-6-8-16(14)28(3)31(4,29)30/h5-11H,1-4H3,(H3,21,22,23,24,25,27)
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UniChem
US Patent
n/an/an/a 0.300n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10647713 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (aa 556-888)


(Homo sapiens (Human))		BDBM442282
PNG
(US10647713, Compound I-243)
Show SMILES Cc1nc2c(Nc3ccccc3P(C)(C)=O)cc(NC(=O)C3CC3)nc2[nH]1
Show InChI InChI=1S/C19H22N5O2P/c1-11-20-17-14(22-13-6-4-5-7-15(13)27(2,3)26)10-16(23-18(17)21-11)24-19(25)12-8-9-12/h4-7,10,12H,8-9H2,1-3H3,(H3,20,21,22,23,24,25)
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UniChem
US Patent
n/an/an/a>10n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10647713 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (aa 556-888)


(Homo sapiens (Human))		BDBM442285
PNG
(US10647713, Compound I-246)
Show SMILES Cc1cn(C)nc1-c1ccc(Nc2cc(NC(=O)C3CC3)nc3[nH]c(nc23)C(F)F)c(c1)S(C)(=O)=O
Show InChI InChI=1S/C23H23F2N7O3S/c1-11-10-32(2)31-18(11)13-6-7-14(16(8-13)36(3,34)35)26-15-9-17(28-23(33)12-4-5-12)27-21-19(15)29-22(30-21)20(24)25/h6-10,12,20H,4-5H2,1-3H3,(H3,26,27,28,29,30,33)
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UniChem
US Patent
n/an/an/a<0.100n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10647713 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (aa 556-888)


(Homo sapiens (Human))		BDBM442295
PNG
(US10647713, Compound I-256)
Show SMILES Cc1nc2c(Nc3ccc(cc3S(C)(=O)=O)[C@H]3CCCCO3)cc(NC(=O)[C@H]3CC3(F)F)nc2[nH]1
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UniChem
US Patent
n/an/an/a 0.75n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10647713 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (aa 556-888)


(Homo sapiens (Human))		BDBM442299
PNG
(US10647713, Compound I-260)
Show SMILES Cc1nc2c(Nc3ccc(cc3S(C)(=O)=O)-c3cncn3C)cc(NC(=O)[C@@H]3C[C@@H]3F)nc2[nH]1
GoogleScholar
UniChem
US Patent
n/an/an/a<0.100n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10647713 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (aa 556-888)


(Homo sapiens (Human))		BDBM442308
PNG
(US10647713, Compound I-269)
Show SMILES CN(c1cc(ccc1Nc1cc(NC(=O)[C@H]2C[C@H]2F)nc2[nH]c(C)nc12)-c1cnn(C)c1)S(C)(=O)=O
GoogleScholar
UniChem
US Patent
n/an/an/a 0.300n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10647713 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (aa 556-888)


(Homo sapiens (Human))		BDBM442311
PNG
(US10647713, Compound I-272)
Show SMILES CS(=O)(=O)c1cc(ccc1Nc1cc(Nc2cccc(n2)C(F)(F)F)nc2[nH]c(nc12)C(F)F)C1CC1
Show InChI InChI=1S/C23H19F5N6O2S/c1-37(35,36)15-9-12(11-5-6-11)7-8-13(15)29-14-10-18(32-21-19(14)33-22(34-21)20(24)25)31-17-4-2-3-16(30-17)23(26,27)28/h2-4,7-11,20H,5-6H2,1H3,(H3,29,30,31,32,33,34)
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UniChem
US Patent
n/an/an/a 5.5n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10647713 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (aa 556-888)


(Homo sapiens (Human))		BDBM442312
PNG
(US10647713, Compound I-273)
Show SMILES Cc1nc2c(Nc3ccc(cc3S(C)(=O)=O)C3CC3)cc(Nc3cccc(n3)C(F)(F)F)nc2[nH]1
Show InChI InChI=1S/C23H21F3N6O2S/c1-12-27-21-16(29-15-9-8-14(13-6-7-13)10-17(15)35(2,33)34)11-20(32-22(21)28-12)31-19-5-3-4-18(30-19)23(24,25)26/h3-5,8-11,13H,6-7H2,1-2H3,(H3,27,28,29,30,31,32)
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UniChem
US Patent
n/an/an/a 0.75n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10647713 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (aa 556-888)


(Homo sapiens (Human))		BDBM442320
PNG
(US10647713, Compound I-281 | US10647713, Compound ...)
Show SMILES CS(=O)(=O)c1cc(ccc1Nc1cc(NC(=O)[C@@H]2CC2(F)F)nc2[nH]c(nc12)C(F)F)[C@H]1CCCCO1
GoogleScholar
UniChem
US Patent
n/an/an/a 5.5n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10647713 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (aa 556-888)


(Homo sapiens (Human))		BDBM442326
PNG
(US10647713, Compound I-287)
Show SMILES CS(=O)(=O)c1cc(ccc1Nc1cc(NC(=O)C2CC2)nc2[nH]c(nc12)C(F)F)-c1ccn(n1)C1CC1
Show InChI InChI=1S/C24H23F2N7O3S/c1-37(35,36)18-10-13(15-8-9-33(32-15)14-5-6-14)4-7-16(18)27-17-11-19(29-24(34)12-2-3-12)28-22-20(17)30-23(31-22)21(25)26/h4,7-12,14,21H,2-3,5-6H2,1H3,(H3,27,28,29,30,31,34)
GoogleScholar
UniChem
US Patent
n/an/an/a 0.300n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10647713 (2020)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%