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Patent code US10647720

Compile Data Set for Download or QSAR

Found 614 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM322657
PNG
(4-(4-(4-ethylpiperazin-1-yl) phenylamino)-2-morpho...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCOCC2)cc1
Show InChI InChI=1S/C22H28N8O2/c1-2-28-7-9-29(10-8-28)17-5-3-16(4-6-17)24-20-19-18(15-23-27-21(19)31)25-22(26-20)30-11-13-32-14-12-30/h3-6,15H,2,7-14H2,1H3,(H,27,31)(H,24,25,26)
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n/an/a<10n/an/an/an/an/an/a



Asan BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10647720 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM322738
PNG
(2-(1-(5-((2-(azepan-1-yl)-5-oxo-5,6- dihydropyrimi...)
Show SMILES OC(=O)CC1CCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cn1
Show InChI InChI=1S/C24H30N8O3/c33-20(34)13-16-7-11-31(12-8-16)19-6-5-17(14-25-19)27-22-21-18(15-26-30-23(21)35)28-24(29-22)32-9-3-1-2-4-10-32/h5-6,14-16H,1-4,7-13H2,(H,30,35)(H,33,34)(H,27,28,29)
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Asan BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10647720 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM322808
PNG
(2-(1-(4-((4-(4-ethyl-3-oxopiperazin-1-yl) phenyl)a...)
Show SMILES CCN1CCN(CC1=O)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCC(CC#N)CC2)cc1
Show InChI InChI=1S/C25H29N9O2/c1-2-32-13-14-34(16-21(32)35)19-5-3-18(4-6-19)28-23-22-20(15-27-31-24(22)36)29-25(30-23)33-11-8-17(7-10-26)9-12-33/h3-6,15,17H,2,7-9,11-14,16H2,1H3,(H,31,36)(H,28,29,30)
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Asan BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10647720 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM442926
PNG
(US10647720, Ex. # 185)
Show SMILES CC1(O)CCN(CCOc2ccc(Nc3nc(nc(C=N)c3C(N)=O)N3CCC(CC#N)CC3)cc2)CC1
Show InChI InChI=1S/C27H36N8O3/c1-27(37)9-14-34(15-10-27)16-17-38-21-4-2-20(3-5-21)31-25-23(24(30)36)22(18-29)32-26(33-25)35-12-7-19(6-11-28)8-13-35/h2-5,18-19,29,37H,6-10,12-17H2,1H3,(H2,30,36)(H,31,32,33)
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Asan BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10647720 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM322816
PNG
(2-(azepan-1-yl)-4-((4-(4- hydroxypiperidin-1-yl)ph...)
Show SMILES NC(=O)c1c(Nc2ccc(cc2)N2CCC(O)CC2)nc(nc1C=N)N1CCCCCC1
Show InChI InChI=1S/C23H31N7O2/c24-15-19-20(21(25)32)22(28-23(27-19)30-11-3-1-2-4-12-30)26-16-5-7-17(8-6-16)29-13-9-18(31)10-14-29/h5-8,15,18,24,31H,1-4,9-14H2,(H2,25,32)(H,26,27,28)
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Asan BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10647720 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM322817
PNG
(2-(1-(4-((4-(4-ethylpiperazin-1-yl) phenyl)amino)-...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2nc(nc(C=N)c2C(N)=O)N2CCC(CC#N)CC2)cc1
Show InChI InChI=1S/C25H33N9O/c1-2-32-13-15-33(16-14-32)20-5-3-19(4-6-20)29-24-22(23(28)35)21(17-27)30-25(31-24)34-11-8-18(7-10-26)9-12-34/h3-6,17-18,27H,2,7-9,11-16H2,1H3,(H2,28,35)(H,29,30,31)
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Asan BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10647720 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM322820
PNG
(2-(azepan-1-yl)-4-((4-(4-(2- hydroxyethyl)piperazi...)
Show SMILES NC(=O)c1c(Nc2ccc(cc2)N2CCN(CCO)CC2)nc(nc1C=N)N1CCCCCC1
Show InChI InChI=1S/C24H34N8O2/c25-17-20-21(22(26)34)23(29-24(28-20)32-9-3-1-2-4-10-32)27-18-5-7-19(8-6-18)31-13-11-30(12-14-31)15-16-33/h5-8,17,25,33H,1-4,9-16H2,(H2,26,34)(H,27,28,29)
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Asan BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10647720 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322825
PNG
(2-(azepan-1-yl)-4-((4-(4-(2-hydroxyethyl) piperidi...)
Show SMILES NC(=O)c1c(Nc2ccc(cc2)N2CCC(CCO)CC2)nc(nc1C=N)N1CCCCCC1
Show InChI InChI=1S/C25H35N7O2/c26-17-21-22(23(27)34)24(30-25(29-21)32-12-3-1-2-4-13-32)28-19-5-7-20(8-6-19)31-14-9-18(10-15-31)11-16-33/h5-8,17-18,26,33H,1-4,9-16H2,(H2,27,34)(H,28,29,30)
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Asan BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10647720 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322826
PNG
(2-(1-(4-((4-(4-(2-hydroxyethyl)piperidin- 1-yl)phe...)
Show SMILES NC(=O)c1c(Nc2ccc(cc2)N2CCC(CCO)CC2)nc(nc1C=N)N1CCC(CC#N)CC1
Show InChI InChI=1S/C26H34N8O2/c27-11-5-18-8-14-34(15-9-18)26-31-22(17-28)23(24(29)36)25(32-26)30-20-1-3-21(4-2-20)33-12-6-19(7-13-33)10-16-35/h1-4,17-19,28,35H,5-10,12-16H2,(H2,29,36)(H,30,31,32)
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Asan BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10647720 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM322827
PNG
(2-(1-(4-((4-(2-(4-ethylpiperazin-1- yl)ethyl)pheny...)
Show SMILES CCN1CCN(CCc2ccc(Nc3nc(nc(C=N)c3C(N)=O)N3CCC(CC#N)CC3)cc2)CC1
Show InChI InChI=1S/C27H37N9O/c1-2-34-15-17-35(18-16-34)12-8-20-3-5-22(6-4-20)31-26-24(25(30)37)23(19-29)32-27(33-26)36-13-9-21(7-11-28)10-14-36/h3-6,19,21,29H,2,7-10,12-18H2,1H3,(H2,30,37)(H,31,32,33)
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Asan BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10647720 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322792
PNG
(2-(4-(4-((2-(4-(cyanomethyl)piperidin-1- yl)-5-oxo...)
Show SMILES OC(=O)CN1CCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCC(CC#N)CC2)cc1
Show InChI InChI=1S/C25H29N9O3/c26-8-5-17-6-9-34(10-7-17)25-29-20-15-27-31-24(37)22(20)23(30-25)28-18-1-3-19(4-2-18)33-13-11-32(12-14-33)16-21(35)36/h1-4,15,17H,5-7,9-14,16H2,(H,31,37)(H,35,36)(H,28,29,30)
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Asan BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10647720 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM322838
PNG
(3-(4-(4-((2-(azepan-1-yl)-5-oxo-5,6- dihydropyrimi...)
Show SMILES NC(=O)c1c(Nc2ccc(cc2)N2CCN(CCC(O)=O)CC2)nc(nc1C=N)N1CCCCCC1
Show InChI InChI=1S/C25H34N8O3/c26-17-20-22(23(27)36)24(30-25(29-20)33-10-3-1-2-4-11-33)28-18-5-7-19(8-6-18)32-15-13-31(14-16-32)12-9-21(34)35/h5-8,17,26H,1-4,9-16H2,(H2,27,36)(H,34,35)(H,28,29,30)
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Asan BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10647720 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322846
PNG
(2-(1-(4-((4-(4-(hydroxymethyl)piperidin- 1-yl)phen...)
Show SMILES NC(=O)c1c(Nc2ccc(cc2)N2CCC(CO)CC2)nc(nc1C=N)N1CCC(CC#N)CC1
Show InChI InChI=1S/C25H32N8O2/c26-10-5-17-6-13-33(14-7-17)25-30-21(15-27)22(23(28)35)24(31-25)29-19-1-3-20(4-2-19)32-11-8-18(16-34)9-12-32/h1-4,15,17-18,27,34H,5-9,11-14,16H2,(H2,28,35)(H,29,30,31)
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Asan BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10647720 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM322850
PNG
(3-(4-(4-((2-(4-(cyanomethyl)piperidin-1- yl)-5-oxo...)
Show SMILES NC(=O)c1c(Nc2ccc(cc2)N2CCN(CCC(O)=O)CC2)nc(nc1C=N)N1CCC(CC#N)CC1
Show InChI InChI=1S/C26H33N9O3/c27-9-5-18-6-11-35(12-7-18)26-31-21(17-28)23(24(29)38)25(32-26)30-19-1-3-20(4-2-19)34-15-13-33(14-16-34)10-8-22(36)37/h1-4,17-18,28H,5-8,10-16H2,(H2,29,38)(H,36,37)(H,30,31,32)
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Asan BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10647720 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM322853
PNG
(2-(1-(4-((4-(4-(2-hydroxy-2- methylpropanoyl)piper...)
Show SMILES CC(C)(O)C(=O)N1CCN(CC1)c1ccc(Nc2nc(nc(C=N)c2C(N)=O)N2CCC(CC#N)CC2)cc1
Show InChI InChI=1S/C27H35N9O3/c1-27(2,39)25(38)35-15-13-34(14-16-35)20-5-3-19(4-6-20)31-24-22(23(30)37)21(17-29)32-26(33-24)36-11-8-18(7-10-28)9-12-36/h3-6,17-18,29,39H,7-9,11-16H2,1-2H3,(H2,30,37)(H,31,32,33)
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Asan BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10647720 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322910
PNG
(2-(1-(4-((4-(4,4-difluoropiperidin-1-yl) phenyl)am...)
Show SMILES FC1(F)CCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCC(CC#N)CC2)cc1
Show InChI InChI=1S/C24H26F2N8O/c25-24(26)8-13-33(14-9-24)18-3-1-17(2-4-18)29-21-20-19(15-28-32-22(20)35)30-23(31-21)34-11-6-16(5-10-27)7-12-34/h1-4,15-16H,5-9,11-14H2,(H,32,35)(H,29,30,31)
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Asan BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10647720 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322936
PNG
(2-(azepan-1-yl)-4-((4-(bis(2- hydroxyethyl)amino)p...)
Show SMILES OCCN(CCO)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1
Show InChI InChI=1S/C22H29N7O3/c30-13-11-28(12-14-31)17-7-5-16(6-8-17)24-20-19-18(15-23-27-21(19)32)25-22(26-20)29-9-3-1-2-4-10-29/h5-8,15,30-31H,1-4,9-14H2,(H,27,32)(H,24,25,26)
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Asan BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10647720 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM322937
PNG
(2-(1-(4-((4-(bis(2-hydroxyethyl)amino) phenyl)amin...)
Show SMILES OCCN(CCO)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCC(CC#N)CC2)cc1
Show InChI InChI=1S/C23H28N8O3/c24-8-5-16-6-9-31(10-7-16)23-27-19-15-25-29-22(34)20(19)21(28-23)26-17-1-3-18(4-2-17)30(11-13-32)12-14-33/h1-4,15-16,32-33H,5-7,9-14H2,(H,29,34)(H,26,27,28)
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Asan BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10647720 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322877
PNG
(2-(azepan-1-yl)-4-((4-(4-methylpiperazin- 1-yl)phe...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1
Show InChI InChI=1S/C23H30N8O/c1-29-12-14-30(15-13-29)18-8-6-17(7-9-18)25-21-20-19(16-24-28-22(20)32)26-23(27-21)31-10-4-2-3-5-11-31/h6-9,16H,2-5,10-15H2,1H3,(H,28,32)(H,25,26,27)
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Asan BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10647720 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM322887
PNG
(2-(1-(4-((4-(4-(2-aminoethyl)piperazin- 1-yl)pheny...)
Show SMILES NCCN1CCN(CC1)c1ccc(Nc2nc(nc(C=N)c2C(N)=O)N2CCC(CC#N)CC2)cc1
Show InChI InChI=1S/C25H34N10O/c26-8-5-18-6-10-35(11-7-18)25-31-21(17-28)22(23(29)36)24(32-25)30-19-1-3-20(4-2-19)34-15-13-33(12-9-27)14-16-34/h1-4,17-18,28H,5-7,9-16,27H2,(H2,29,36)(H,30,31,32)
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Asan BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10647720 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322894
PNG
(2-(1-(4-((4-(4-(2-hydroxyethyl)-1,4- diazepan-1-yl...)
Show SMILES OCCN1CCCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCC(CC#N)CC2)cc1
Show InChI InChI=1S/C26H33N9O2/c27-9-6-19-7-12-35(13-8-19)26-30-22-18-28-32-25(37)23(22)24(31-26)29-20-2-4-21(5-3-20)34-11-1-10-33(14-15-34)16-17-36/h2-5,18-19,36H,1,6-8,10-17H2,(H,32,37)(H,29,30,31)
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Asan BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10647720 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322944
PNG
(2-(azepan-1-yl)-4-((4-((1-hydroxy-2- methylpropan-...)
Show SMILES CC(C)(CO)Oc1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1
Show InChI InChI=1S/C22H28N6O3/c1-22(2,14-29)31-16-9-7-15(8-10-16)24-19-18-17(13-23-27-20(18)30)25-21(26-19)28-11-5-3-4-6-12-28/h7-10,13,29H,3-6,11-12,14H2,1-2H3,(H,27,30)(H,24,25,26)
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Asan BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10647720 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM322692
PNG
(6-(4-((2-(azepan-1-yl)-5-oxo-5,6- dihydropyrimido[...)
Show SMILES OC(=O)C1CC11CCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1
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Asan BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10647720 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM322898
PNG
(2-(1-(4-((4-(4-(2-(dimethylamino)ethyl) piperazin-...)
Show SMILES CN(C)CCN1CCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCC(CC#N)CC2)cc1
Show InChI InChI=1S/C27H36N10O/c1-34(2)13-14-35-15-17-36(18-16-35)22-5-3-21(4-6-22)30-25-24-23(19-29-33-26(24)38)31-27(32-25)37-11-8-20(7-10-28)9-12-37/h3-6,19-20H,7-9,11-18H2,1-2H3,(H,33,38)(H,30,31,32)
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Asan BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10647720 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM322884
PNG
(2-(4-(4-((2-(azepan-1-yl)-5-oxo-5,6- dihydropyrimi...)
Show SMILES OC(=O)CN1CCC(CC1)Oc1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1
Show InChI InChI=1S/C25H31N7O4/c33-21(34)16-31-13-9-19(10-14-31)36-18-7-5-17(6-8-18)27-23-22-20(15-26-30-24(22)35)28-25(29-23)32-11-3-1-2-4-12-32/h5-8,15,19H,1-4,9-14,16H2,(H,30,35)(H,33,34)(H,27,28,29)
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Asan BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10647720 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322885
PNG
(2-(azepan-1-yl)-4-((4-(4-(2-methoxyethyl) piperazi...)
Show SMILES COCCN1CCN(CC1)c1ccc(Nc2nc(nc(C=N)c2C(N)=O)N2CCCCCC2)cc1
Show InChI InChI=1S/C25H36N8O2/c1-35-17-16-31-12-14-32(15-13-31)20-8-6-19(7-9-20)28-24-22(23(27)34)21(18-26)29-25(30-24)33-10-4-2-3-5-11-33/h6-9,18,26H,2-5,10-17H2,1H3,(H2,27,34)(H,28,29,30)
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Asan BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10647720 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM322894
PNG
(2-(1-(4-((4-(4-(2-hydroxyethyl)-1,4- diazepan-1-yl...)
Show SMILES OCCN1CCCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCC(CC#N)CC2)cc1
Show InChI InChI=1S/C26H33N9O2/c27-9-6-19-7-12-35(13-8-19)26-30-22-18-28-32-25(37)23(22)24(31-26)29-20-2-4-21(5-3-20)34-11-1-10-33(14-15-34)16-17-36/h2-5,18-19,36H,1,6-8,10-17H2,(H,32,37)(H,29,30,31)
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Asan BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10647720 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM322896
PNG
(2-(1-(4-((4-(4-(1-hydroxy-2- methylpropan-2-yl)pip...)
Show SMILES CC(C)(CO)N1CCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCC(CC#N)CC2)cc1
Show InChI InChI=1S/C27H35N9O2/c1-27(2,18-37)36-15-13-34(14-16-36)21-5-3-20(4-6-21)30-24-23-22(17-29-33-25(23)38)31-26(32-24)35-11-8-19(7-10-28)9-12-35/h3-6,17,19,37H,7-9,11-16,18H2,1-2H3,(H,33,38)(H,30,31,32)
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Asan BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10647720 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM322668
PNG
(4-(4-(4-ethylpiperazin-1-yl)phenylamino)- 2-(thiop...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)-c2ccsc2)cc1
Show InChI InChI=1S/C22H23N7OS/c1-2-28-8-10-29(11-9-28)17-5-3-16(4-6-17)24-21-19-18(13-23-27-22(19)30)25-20(26-21)15-7-12-31-14-15/h3-7,12-14H,2,8-11H2,1H3,(H,27,30)(H,24,25,26)
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Asan BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10647720 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM322683
PNG
(2-(azepan-1-yl)-4-((4-(piperazin-1- ylmethyl)pheny...)
Show SMILES O=c1[nH]ncc2nc(nc(Nc3ccc(CN4CCNCC4)cc3)c12)N1CCCCCC1
Show InChI InChI=1S/C23H30N8O/c32-22-20-19(15-25-29-22)27-23(31-11-3-1-2-4-12-31)28-21(20)26-18-7-5-17(6-8-18)16-30-13-9-24-10-14-30/h5-8,15,24H,1-4,9-14,16H2,(H,29,32)(H,26,27,28)
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Asan BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10647720 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322690
PNG
(2-(azepan-1-yl)-4-((4-morpholinophenyl) amino)pyri...)
Show SMILES O=c1[nH]ncc2nc(nc(Nc3ccc(cc3)N3CCOCC3)c12)N1CCCCCC1
Show InChI InChI=1S/C22H27N7O2/c30-21-19-18(15-23-27-21)25-22(29-9-3-1-2-4-10-29)26-20(19)24-16-5-7-17(8-6-16)28-11-13-31-14-12-28/h5-8,15H,1-4,9-14H2,(H,27,30)(H,24,25,26)
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Asan BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10647720 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM322897
PNG
(2-(azepan-1-yl)-4-((4-(4-(2- (dimethylamino)ethyl)...)
Show SMILES CN(C)CCN1CCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1
Show InChI InChI=1S/C26H37N9O/c1-32(2)13-14-33-15-17-34(18-16-33)21-9-7-20(8-10-21)28-24-23-22(19-27-31-25(23)36)29-26(30-24)35-11-5-3-4-6-12-35/h7-10,19H,3-6,11-18H2,1-2H3,(H,31,36)(H,28,29,30)
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Asan BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10647720 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322903
PNG
(2-(azepan-1-yl)-4-((4-(4-(2,3- dihydroxypropyl)pip...)
Show SMILES OCC(O)CN1CCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1
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Asan BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10647720 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM322904
PNG
(2-(1-(4-((4-(4-(2,3-dihydroxypropyl) piperazin-1-y...)
Show SMILES NC(=O)c1c(Nc2ccc(cc2)N2CCN(CC(O)CO)CC2)nc(nc1C=N)N1CCC(CC#N)CC1
Show InChI InChI=1S/C26H35N9O3/c27-8-5-18-6-9-35(10-7-18)26-31-22(15-28)23(24(29)38)25(32-26)30-19-1-3-20(4-2-19)34-13-11-33(12-14-34)16-21(37)17-36/h1-4,15,18,21,28,36-37H,5-7,9-14,16-17H2,(H2,29,38)(H,30,31,32)
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Asan BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10647720 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM322906
PNG
(2-(1-(4-((4-(4-(2-fluoroethyl)piperazin-1- yl)phen...)
Show SMILES FCCN1CCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCC(CC#N)CC2)cc1
Show InChI InChI=1S/C25H30FN9O/c26-8-12-33-13-15-34(16-14-33)20-3-1-19(2-4-20)29-23-22-21(17-28-32-24(22)36)30-25(31-23)35-10-6-18(5-9-27)7-11-35/h1-4,17-18H,5-8,10-16H2,(H,32,36)(H,29,30,31)
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Asan BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10647720 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322711
PNG
(6-(4-((2-cycloheptyl-5-oxo-5,6- dihydropyrimido[4,...)
Show SMILES OC(=O)C1CC11CCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)C2CCCCCC2)cc1
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Asan BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10647720 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM322722
PNG
(4-(4-((2-(azepan-1-yl)-5-oxo-5,6- dihydropyrimido[...)
Show SMILES OC(=O)CCCOc1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1
Show InChI InChI=1S/C22H26N6O4/c29-18(30)6-5-13-32-16-9-7-15(8-10-16)24-20-19-17(14-23-27-21(19)31)25-22(26-20)28-11-3-1-2-4-12-28/h7-10,14H,1-6,11-13H2,(H,27,31)(H,29,30)(H,24,25,26)
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Asan BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10647720 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322638
PNG
(2-phenyl-4-(4-(piperazin-1-yl) phenylamino)pyrimid...)
Show SMILES O=c1[nH]ncc2nc(nc(Nc3ccc(cc3)N3CCNCC3)c12)-c1ccccc1
Show InChI InChI=1S/C22H21N7O/c30-22-19-18(14-24-28-22)26-20(15-4-2-1-3-5-15)27-21(19)25-16-6-8-17(9-7-16)29-12-10-23-11-13-29/h1-9,14,23H,10-13H2,(H,28,30)(H,25,26,27)
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Asan BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10647720 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322642
PNG
(2-(4-(4-(5-oxo-2-phenyl-5,6- dihydropyrimido[4,5-d...)
Show SMILES OC(=O)CN1CCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)-c2ccccc2)cc1
Show InChI InChI=1S/C24H23N7O3/c32-20(33)15-30-10-12-31(13-11-30)18-8-6-17(7-9-18)26-23-21-19(14-25-29-24(21)34)27-22(28-23)16-4-2-1-3-5-16/h1-9,14H,10-13,15H2,(H,29,34)(H,32,33)(H,26,27,28)
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Asan BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10647720 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322710
PNG
(2-(1-(4-((2-(azepan-1-yl)-5-oxo-5,6- dihydropyrimi...)
Show SMILES O=c1[nH]ncc2nc(nc(Nc3ccc(cc3)N3CCC(CC#N)CC3)c12)N1CCCCCC1
Show InChI InChI=1S/C25H30N8O/c26-12-9-18-10-15-32(16-11-18)20-7-5-19(6-8-20)28-23-22-21(17-27-31-24(22)34)29-25(30-23)33-13-3-1-2-4-14-33/h5-8,17-18H,1-4,9-11,13-16H2,(H,31,34)(H,28,29,30)
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Asan BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10647720 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322747
PNG
(2-(1-(4-((2-(3,5-dimethylpiperidin-1-yl)- 5-oxo-5,...)
Show SMILES CC1CC(C)CN(C1)c1nc(Nc2ccc(cc2)N2CCC(CC(O)=O)CC2)c2c(cn[nH]c2=O)n1
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Asan BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10647720 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322760
PNG
(3-(1-(4-((2-(azepan-1-yl)-5-oxo-5,6- dihydropyrimi...)
Show SMILES OC(=O)CCC1CCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1
Show InChI InChI=1S/C26H33N7O3/c34-22(35)10-5-18-11-15-32(16-12-18)20-8-6-19(7-9-20)28-24-23-21(17-27-31-25(23)36)29-26(30-24)33-13-3-1-2-4-14-33/h6-9,17-18H,1-5,10-16H2,(H,31,36)(H,34,35)(H,28,29,30)
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Asan BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10647720 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322762
PNG
(3-(1-(4-((5-oxo-2-phenyl-5,6- dihydropyrimido[4,5-...)
Show SMILES OC(=O)CCC1CCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)-c2ccccc2)cc1
Show InChI InChI=1S/C26H26N6O3/c33-22(34)11-6-17-12-14-32(15-13-17)20-9-7-19(8-10-20)28-25-23-21(16-27-31-26(23)35)29-24(30-25)18-4-2-1-3-5-18/h1-5,7-10,16-17H,6,11-15H2,(H,31,35)(H,33,34)(H,28,29,30)
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Asan BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10647720 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM322765
PNG
(6-(4-((2-(azepan-1-yl)-5-oxo-5,6- dihydropyrimido[...)
Show SMILES OC(=O)C1CC11CCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1F
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Asan BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10647720 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322812
PNG
(2-(azepan-1-yl)-4-((6-(2-(piperazin-1-yl) ethoxy)p...)
Show SMILES O=c1[nH]ncc2nc(nc(Nc3ccc(OCCN4CCNCC4)nc3)c12)N1CCCCCC1
Show InChI InChI=1S/C23H31N9O2/c33-22-20-18(16-26-30-22)28-23(32-9-3-1-2-4-10-32)29-21(20)27-17-5-6-19(25-15-17)34-14-13-31-11-7-24-8-12-31/h5-6,15-16,24H,1-4,7-14H2,(H,30,33)(H,27,28,29)
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Asan BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10647720 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM322822
PNG
(2-(azepan-1-yl)-4-((4-(piperazin-1-yl) phenyl)amin...)
Show SMILES NC(=O)c1c(Nc2ccc(cc2)N2CCNCC2)nc(nc1C=N)N1CCCCCC1
Show InChI InChI=1S/C22H30N8O/c23-15-18-19(20(24)31)21(28-22(27-18)30-11-3-1-2-4-12-30)26-16-5-7-17(8-6-16)29-13-9-25-10-14-29/h5-8,15,23,25H,1-4,9-14H2,(H2,24,31)(H,26,27,28)
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Asan BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10647720 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM322826
PNG
(2-(1-(4-((4-(4-(2-hydroxyethyl)piperidin- 1-yl)phe...)
Show SMILES NC(=O)c1c(Nc2ccc(cc2)N2CCC(CCO)CC2)nc(nc1C=N)N1CCC(CC#N)CC1
Show InChI InChI=1S/C26H34N8O2/c27-11-5-18-8-14-34(15-9-18)26-31-22(17-28)23(24(29)36)25(32-26)30-20-1-3-21(4-2-20)33-12-6-19(7-13-33)10-16-35/h1-4,17-19,28,35H,5-10,12-16H2,(H2,29,36)(H,30,31,32)
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Asan BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10647720 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322828
PNG
(2-(azepan-1-yl)-4-((4-(2-(piperazin-1- yl)ethyl)ph...)
Show SMILES NC(=O)c1c(Nc2ccc(CCN3CCNCC3)cc2)nc(nc1C=N)N1CCCCCC1
Show InChI InChI=1S/C24H34N8O/c25-17-20-21(22(26)33)23(30-24(29-20)32-12-3-1-2-4-13-32)28-19-7-5-18(6-8-19)9-14-31-15-10-27-11-16-31/h5-8,17,25,27H,1-4,9-16H2,(H2,26,33)(H,28,29,30)
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Asan BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10647720 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM322845
PNG
(3-(4-(4-((2-(azepan-1-yl)-5-oxo-5,6- dihydropyrimi...)
Show SMILES NC(=O)c1c(Nc2ccc(cc2)N2CCN(CC2)C(=O)CC#N)nc(nc1C=N)N1CCCCCC1
Show InChI InChI=1S/C25H31N9O2/c26-10-9-21(35)33-15-13-32(14-16-33)19-7-5-18(6-8-19)29-24-22(23(28)36)20(17-27)30-25(31-24)34-11-3-1-2-4-12-34/h5-8,17,27H,1-4,9,11-16H2,(H2,28,36)(H,29,30,31)
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Asan BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10647720 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM322846
PNG
(2-(1-(4-((4-(4-(hydroxymethyl)piperidin- 1-yl)phen...)
Show SMILES NC(=O)c1c(Nc2ccc(cc2)N2CCC(CO)CC2)nc(nc1C=N)N1CCC(CC#N)CC1
Show InChI InChI=1S/C25H32N8O2/c26-10-5-17-6-13-33(14-7-17)25-30-21(15-27)22(23(28)35)24(31-25)29-19-1-3-20(4-2-19)32-11-8-18(16-34)9-12-32/h1-4,15,17-18,27,34H,5-9,11-14,16H2,(H2,28,35)(H,29,30,31)
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Asan BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10647720 (2020)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%