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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Phosphodiesterase (Macaca mulatta (Rhesus macaque)) | BDBM442759 (6-Chloro-N,1-dimethyl-N-{1-[4-(trifluoromethyl)phe...) | PDB UniProtKB/TrEMBL GoogleScholar | UniChem | US Patent | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase () | BDBM50452209 (CHEMBL4207777 | US10647727, Example 9) | PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem | US Patent | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase () | BDBM442759 (6-Chloro-N,1-dimethyl-N-{1-[4-(trifluoromethyl)phe...) | PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 3.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Phosphodiesterase (Macaca mulatta (Rhesus macaque)) | BDBM50452209 (CHEMBL4207777 | US10647727, Example 9) | PDB UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | 4.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase () | BDBM442769 (N,1,6-Trimethyl-N-{1-[4-(trifluoromethyl)phenyl]cy...) | PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 4.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Phosphodiesterase (Macaca mulatta (Rhesus macaque)) | BDBM50452200 (CHEMBL4212416 | US10647727, Example 20) | PDB UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | 5.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Phosphodiesterase (Macaca mulatta (Rhesus macaque)) | BDBM442759 (6-Chloro-N,1-dimethyl-N-{1-[4-(trifluoromethyl)phe...) | PDB UniProtKB/TrEMBL GoogleScholar | UniChem | US Patent | 6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase () | BDBM50452200 (CHEMBL4212416 | US10647727, Example 20) | PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem | US Patent | 6.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase () | BDBM50452200 (CHEMBL4212416 | US10647727, Example 20) | PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem | US Patent | 8.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase () | BDBM442766 (1,6-Dimethyl-N- (1-{4- [(trifluoromethyl)- sulfany...) | PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Phosphodiesterase (Macaca mulatta (Rhesus macaque)) | BDBM442766 (1,6-Dimethyl-N- (1-{4- [(trifluoromethyl)- sulfany...) | PDB UniProtKB/TrEMBL GoogleScholar | UniChem | US Patent | 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Phosphodiesterase (Macaca mulatta (Rhesus macaque)) | BDBM50452216 (CHEMBL4215537 | US10647727, Example 13) | PDB UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase () | BDBM442767 (N-{1-[2-Fluoro-4- (trifluoromethyl)- phenyl]cyclo-...) | PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 29 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase () | BDBM442773 (1,6-Dimethyl-4-({1-[4-(trifluoromethyl)phenyl]cycl...) | PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 32 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase () | BDBM442765 (N-{1-[3-Fluoro-4- (trifluoromethyl)- phenyl]cyclo-...) | PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 35 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase () | BDBM442772 (1-Methyl-4-{1-[4-(trifluoromethyl)phenyl]cycloprop...) | PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 39 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase () | BDBM442770 (N,1,6-Trimethyl-N-(1-{4-[(trifluoromethyl)sulfanyl...) | PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Phosphodiesterase (Macaca mulatta (Rhesus macaque)) | BDBM442772 (1-Methyl-4-{1-[4-(trifluoromethyl)phenyl]cycloprop...) | PDB UniProtKB/TrEMBL GoogleScholar | UniChem | US Patent | 47 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase () | BDBM442775 ((R)—N-(1-(3-Fluoro-4-(trifluoromethyl)phenyl)-2,2-...) | PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 51 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Phosphodiesterase (Macaca mulatta (Rhesus macaque)) | BDBM442765 (N-{1-[3-Fluoro-4- (trifluoromethyl)- phenyl]cyclo-...) | PDB UniProtKB/TrEMBL GoogleScholar | UniChem | US Patent | 55 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase () | BDBM50452216 (CHEMBL4215537 | US10647727, Example 13) | PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem | US Patent | 55 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase () | BDBM442774 (N-(1-(3-Fluoro-4-(trifluoromethyl)phenyl)cycloprop...) | PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 55 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase () | BDBM442756 (6-Chloro-N,1-dimethyl-N-{(1R)-1-[4-(trifluoromethy...) | PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 65 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase () | BDBM442761 (1-Methyl-6-(trifluoromethyl)-N-(1-(4-(trifluoromet...) | PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 67 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Phosphodiesterase (Macaca mulatta (Rhesus macaque)) | BDBM50452216 (CHEMBL4215537 | US10647727, Example 13) | PDB UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | 72 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase () | BDBM442771 (N-{1-[3-Fluoro-4-(trifluoromethyl)phenyl]cycloprop...) | PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 76 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Phosphodiesterase (Macaca mulatta (Rhesus macaque)) | BDBM442761 (1-Methyl-6-(trifluoromethyl)-N-(1-(4-(trifluoromet...) | PDB UniProtKB/TrEMBL GoogleScholar | UniChem | US Patent | 80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Phosphodiesterase (Macaca mulatta (Rhesus macaque)) | BDBM442771 (N-{1-[3-Fluoro-4-(trifluoromethyl)phenyl]cycloprop...) | PDB UniProtKB/TrEMBL GoogleScholar | UniChem | US Patent | 98 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase () | BDBM442780 (N-(1-(3-Fluoro-4-(trifluoromethyl)phenyl)cycloprop...) | PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 115 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Phosphodiesterase (Macaca mulatta (Rhesus macaque)) | BDBM442756 (6-Chloro-N,1-dimethyl-N-{(1R)-1-[4-(trifluoromethy...) | PDB UniProtKB/TrEMBL GoogleScholar | UniChem | US Patent | 137 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase () | BDBM442763 (1,6-Dimethyl- N-{(1R)-1-[4- (trifluoromethyl)- phe...) | PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 140 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase () | BDBM50452210 (CHEMBL4202746 | US10647727, Example 12) | PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem | US Patent | 141 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase () | BDBM442786 (US10647727, Example 43 | [7-({1-[3-Fluoro-4-(trifl...) | PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 169 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase () | BDBM442791 (N-{(1R)-1-[3-Fluoro-4-(trifluoromethyl)phenyl]-2,2...) | PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 174 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Phosphodiesterase (Macaca mulatta (Rhesus macaque)) | BDBM442763 (1,6-Dimethyl- N-{(1R)-1-[4- (trifluoromethyl)- phe...) | PDB UniProtKB/TrEMBL GoogleScholar | UniChem | US Patent | 194 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Phosphodiesterase (Macaca mulatta (Rhesus macaque)) | BDBM50452210 (CHEMBL4202746 | US10647727, Example 12) | PDB UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | 196 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase () | BDBM442790 (N-{1-[3-Fluoro-4-(trifluoromethyl)phenyl]cycloprop...) | PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 199 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase () | BDBM442779 (N-{1-[3-Fluoro-4-(trifluoromethyl)phenyl]cycloprop...) | PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 206 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Phosphodiesterase (Macaca mulatta (Rhesus macaque)) | BDBM50452215 (CHEMBL4212115 | US10647727, Example 2) | PDB UniProtKB/TrEMBL GoogleScholar | PC cid PC sid PDB UniChem | PDB US Patent | 237 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair |  3D Structure (crystal) | ||||||||||||
| 3',5'-cyclic phosphodiesterase () | BDBM442787 (US10647727, Example 44 | [7-({(1R)-1-[3-Fluoro-4-(...) | PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 259 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Phosphodiesterase (Macaca mulatta (Rhesus macaque)) | BDBM442743 (6-Chloro-1-methyl-N-{1-[4-(trifluoromethyl)phenyl]...) | PDB UniProtKB/TrEMBL GoogleScholar | UniChem | US Patent | 290 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Phosphodiesterase (Macaca mulatta (Rhesus macaque)) | BDBM442752 (6-Chloro-N-{(1R)-[4-(trifluoromethyl)phenyl]ethyl}...) | PDB UniProtKB/TrEMBL GoogleScholar | UniChem | US Patent | 308 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase () | BDBM442784 (N7-{1-[3-Fluoro-4-(trifluoromethyl)phenyl]cyclopro...) | PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 337 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Phosphodiesterase (Macaca mulatta (Rhesus macaque)) | BDBM442768 (1,6-Dimethyl-N- {1-[4-(trifluoro- methyl)phenyl]- ...) | PDB UniProtKB/TrEMBL GoogleScholar | UniChem | US Patent | 358 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase () | BDBM50452215 (CHEMBL4212115 | US10647727, Example 2) | PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar | PC cid PC sid PDB UniChem | PDB US Patent | 392 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Phosphodiesterase (Macaca mulatta (Rhesus macaque)) | BDBM442747 (6-Chloro-1- methyl-N-{1-[4- (1-methylethyl)- pheny...) | PDB UniProtKB/TrEMBL GoogleScholar | UniChem | US Patent | 401 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase () | BDBM442758 (6-Chloro-N-ethyl-1- methyl-N-[4- (trifluoromethyl)...) | PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 429 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase () | BDBM442768 (1,6-Dimethyl-N- {1-[4-(trifluoro- methyl)phenyl]- ...) | PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 430 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase () | BDBM442783 (7-({(1R)-1-[3-Fluoro-4-(trifluoromethyl)phenyl]-2,...) | PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 462 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Phosphodiesterase (Macaca mulatta (Rhesus macaque)) | BDBM442748 (6-Chloro-1- methyl-N-{1-[4- (1-methylethyl)- pheny...) | PDB UniProtKB/TrEMBL GoogleScholar | UniChem | US Patent | 468 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase () | BDBM442782 (US10647727, Example 39) | PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 503 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase () | BDBM442778 (N-{(1R)-1-[3-Fluoro-4-(trifluoromethyl)phenyl]-2,2...) | PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 566 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase () | BDBM442785 (N7-{(1R)-1-[3-Fluoro-4-(trifluoromethyl)phenyl]-2,...) | PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 580 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Phosphodiesterase (Macaca mulatta (Rhesus macaque)) | BDBM50452198 (CHEMBL4207234 | US10647727, Example 8) | PDB UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | 642 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase () | BDBM442788 (US10647727, Example 45 | [7-({1-[3-Fluoro-4-(trifl...) | PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 682 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Phosphodiesterase (Macaca mulatta (Rhesus macaque)) | BDBM442758 (6-Chloro-N-ethyl-1- methyl-N-[4- (trifluoromethyl)...) | PDB UniProtKB/TrEMBL GoogleScholar | UniChem | US Patent | 866 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Phosphodiesterase (Macaca mulatta (Rhesus macaque)) | BDBM442757 (6-Chloro-N,1- dimethyl-N- [4-(trifluoromethyl)- be...) | PDB UniProtKB/TrEMBL GoogleScholar | UniChem | US Patent | 997 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase () | BDBM442776 ((R or S)-1-[3-Fluoro-4-(trifluoromethyl)phenyl]-2-...) | PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 1.33E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Phosphodiesterase (Macaca mulatta (Rhesus macaque)) | BDBM442753 (6-Chloro-N- {(1S)-[4- (trifluoromethyl)- phenyl]et...) | PDB UniProtKB/TrEMBL GoogleScholar | UniChem | US Patent | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Phosphodiesterase (Macaca mulatta (Rhesus macaque)) | BDBM442760 (6-Chloro-1-(1-methylethyl)-N-{1-[4-(trifluoromethy...) | PDB UniProtKB/TrEMBL GoogleScholar | UniChem | US Patent | 1.97E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase () | BDBM442781 (N-{(1R)-1-[3-fluoro-4-(trifluoromethyl)phenyl]-2,2...) | PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 2.06E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Phosphodiesterase (Macaca mulatta (Rhesus macaque)) | BDBM50452206 (CHEMBL4209385 | US10647727, Example 4) | PDB UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | 2.34E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase () | BDBM442789 (US10647727, Example 46 | [7-({1-[3-Fluoro-4-(trifl...) | PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 2.64E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Phosphodiesterase (Macaca mulatta (Rhesus macaque)) | BDBM442749 (6-Chloro-1- methyl-N-{1- [4-(1H-pyrazol- 1-yl)phen...) | PDB UniProtKB/TrEMBL GoogleScholar | UniChem | US Patent | 2.65E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase () | BDBM442776 ((R or S)-1-[3-Fluoro-4-(trifluoromethyl)phenyl]-2-...) | PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar | UniChem | US Patent | >2.96E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Phosphodiesterase (Macaca mulatta (Rhesus macaque)) | BDBM442745 (Ethyl 7-chloro-5-methylpyrazolo[1,5-a]pyrimidine-3...) | PDB UniProtKB/TrEMBL GoogleScholar | UniChem | US Patent | 4.79E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US10647727 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
