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Patent code US10654831

Compile Data Set for Download or QSAR
Found 85 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclin-Dependent Kinase 4 (CDK4)


(Homo sapiens (Human))
BDBM443117
PNG
(US10654831, Compound 20)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2CC(=O)NCC22CCCCC2)nc1
Show InChI InChI=1S/C23H32N8O/c1-29-11-13-30(14-12-29)18-5-6-19(25-15-18)27-22-24-10-7-20(28-22)31-16-21(32)26-17-23(31)8-3-2-4-9-23/h5-7,10,15H,2-4,8-9,11-14,16-17H2,1H3,(H,26,32)(H,24,25,27,28)
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n/an/a 440n/an/an/an/an/an/a



G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (Human))
BDBM443117
PNG
(US10654831, Compound 20)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2CC(=O)NCC22CCCCC2)nc1
Show InChI InChI=1S/C23H32N8O/c1-29-11-13-30(14-12-29)18-5-6-19(25-15-18)27-22-24-10-7-20(28-22)31-16-21(32)26-17-23(31)8-3-2-4-9-23/h5-7,10,15H,2-4,8-9,11-14,16-17H2,1H3,(H,26,32)(H,24,25,27,28)
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n/an/a 750n/an/an/an/an/an/a



G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 4 (CDK4)


(Homo sapiens (Human))
BDBM443121
PNG
(US10654831, Compound 46)
Show SMILES CC(C)[C@H]1CNC(=O)N1c1ccnc(Nc2ccc(cn2)N2CCN(C)CC2)n1
Show InChI InChI=1S/C20H28N8O/c1-14(2)16-13-23-20(29)28(16)18-6-7-21-19(25-18)24-17-5-4-15(12-22-17)27-10-8-26(3)9-11-27/h4-7,12,14,16H,8-11,13H2,1-3H3,(H,23,29)(H,21,22,24,25)/t16-/m1/s1
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n/an/a 761n/an/an/an/an/an/a



G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
CDK6/CycD3


(Homo sapiens (Human))
BDBM443117
PNG
(US10654831, Compound 20)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2CC(=O)NCC22CCCCC2)nc1
Show InChI InChI=1S/C23H32N8O/c1-29-11-13-30(14-12-29)18-5-6-19(25-15-18)27-22-24-10-7-20(28-22)31-16-21(32)26-17-23(31)8-3-2-4-9-23/h5-7,10,15H,2-4,8-9,11-14,16-17H2,1H3,(H,26,32)(H,24,25,27,28)
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n/an/a 1.00E+3n/an/an/an/an/an/a



G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 4 (CDK4)


(Homo sapiens (Human))
BDBM443113
PNG
(US10654831, Compound 6)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2C(=O)NCC22CCCCC2)nc1
Show InChI InChI=1S/C22H30N8O/c1-28-11-13-29(14-12-28)17-5-6-18(24-15-17)26-20-23-10-7-19(27-20)30-21(31)25-16-22(30)8-3-2-4-9-22/h5-7,10,15H,2-4,8-9,11-14,16H2,1H3,(H,25,31)(H,23,24,26,27)
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n/an/a 1.00E+3n/an/an/an/an/an/a



G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 4 (CDK4)


(Homo sapiens (Human))
BDBM443122
PNG
(US10654831, Compound 52)
Show SMILES C[C@H]1CNC(=O)N1c1ccnc(Nc2ccc(cn2)N2CCN(C)CC2)n1
Show InChI InChI=1S/C18H24N8O/c1-13-11-21-18(27)26(13)16-5-6-19-17(23-16)22-15-4-3-14(12-20-15)25-9-7-24(2)8-10-25/h3-6,12-13H,7-11H2,1-2H3,(H,21,27)(H,19,20,22,23)/t13-/m0/s1
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n/an/a 1.50E+3n/an/an/an/an/an/a



G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 4 (CDK4)


(Homo sapiens (Human))
BDBM443120
PNG
(US10654831, Compound 40)
Show SMILES C[C@H]1CNC(=O)CN1c1ccnc(Nc2ccc(cn2)N2CCN(C)CC2)n1
Show InChI InChI=1S/C19H26N8O/c1-14-11-22-18(28)13-27(14)17-5-6-20-19(24-17)23-16-4-3-15(12-21-16)26-9-7-25(2)8-10-26/h3-6,12,14H,7-11,13H2,1-2H3,(H,22,28)(H,20,21,23,24)/t14-/m0/s1
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n/an/a 1.70E+3n/an/an/an/an/an/a



G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 4 (CDK4)


(Homo sapiens (Human))
BDBM443115
PNG
(US10654831, Compound 10)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2C(=O)N(Cc3ccccc3)CC22CCCCC2)nc1
Show InChI InChI=1S/C29H36N8O/c1-34-16-18-35(19-17-34)24-10-11-25(31-20-24)32-27-30-15-12-26(33-27)37-28(38)36(21-23-8-4-2-5-9-23)22-29(37)13-6-3-7-14-29/h2,4-5,8-12,15,20H,3,6-7,13-14,16-19,21-22H2,1H3,(H,30,31,32,33)
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n/an/a 2.71E+3n/an/an/an/an/an/a



G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 4 (CDK4)


(Homo sapiens (Human))
BDBM443114
PNG
(US10654831, Compound 8)
Show SMILES CN1CC2(CCCCC2)N(C1=O)c1ccnc(Nc2ccc(cn2)N2CCN(C)CC2)n1
Show InChI InChI=1S/C23H32N8O/c1-28-12-14-30(15-13-28)18-6-7-19(25-16-18)26-21-24-11-8-20(27-21)31-22(32)29(2)17-23(31)9-4-3-5-10-23/h6-8,11,16H,3-5,9-10,12-15,17H2,1-2H3,(H,24,25,26,27)
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n/an/a 3.27E+3n/an/an/an/an/an/a



G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
CDK6/CycD3


(Homo sapiens (Human))
BDBM443121
PNG
(US10654831, Compound 46)
Show SMILES CC(C)[C@H]1CNC(=O)N1c1ccnc(Nc2ccc(cn2)N2CCN(C)CC2)n1
Show InChI InChI=1S/C20H28N8O/c1-14(2)16-13-23-20(29)28(16)18-6-7-21-19(25-18)24-17-5-4-15(12-22-17)27-10-8-26(3)9-11-27/h4-7,12,14,16H,8-11,13H2,1-3H3,(H,23,29)(H,21,22,24,25)/t16-/m1/s1
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n/an/a 3.30E+3n/an/an/an/an/an/a



G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
CDK6/CycD3


(Homo sapiens (Human))
BDBM443116
PNG
(US10654831, Compound 16)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2CCNC2=O)nc1
Show InChI InChI=1S/C17H22N8O/c1-23-8-10-24(11-9-23)13-2-3-14(20-12-13)21-16-18-5-4-15(22-16)25-7-6-19-17(25)26/h2-5,12H,6-11H2,1H3,(H,19,26)(H,18,20,21,22)
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n/an/a 3.40E+3n/an/an/an/an/an/a



G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
CDK6/CycD3


(Homo sapiens (Human))
BDBM443122
PNG
(US10654831, Compound 52)
Show SMILES C[C@H]1CNC(=O)N1c1ccnc(Nc2ccc(cn2)N2CCN(C)CC2)n1
Show InChI InChI=1S/C18H24N8O/c1-13-11-21-18(27)26(13)16-5-6-19-17(23-16)22-15-4-3-14(12-20-15)25-9-7-24(2)8-10-25/h3-6,12-13H,7-11H2,1-2H3,(H,21,27)(H,19,20,22,23)/t13-/m0/s1
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n/an/a 4.00E+3n/an/an/an/an/an/a



G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 4 (CDK4)


(Homo sapiens (Human))
BDBM443126
PNG
(US10654831, Compound 56)
Show SMILES CC[C@H]1CC(=O)NN1c1ccnc(Nc2ccc(cn2)N2CCN(C)CC2)n1
Show InChI InChI=1S/C19H26N8O/c1-3-14-12-18(28)24-27(14)17-6-7-20-19(23-17)22-16-5-4-15(13-21-16)26-10-8-25(2)9-11-26/h4-7,13-14H,3,8-12H2,1-2H3,(H,24,28)(H,20,21,22,23)/t14-/m0/s1
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n/an/a 4.00E+3n/an/an/an/an/an/a



G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
CDK6/CycD3


(Homo sapiens (Human))
BDBM443113
PNG
(US10654831, Compound 6)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2C(=O)NCC22CCCCC2)nc1
Show InChI InChI=1S/C22H30N8O/c1-28-11-13-29(14-12-28)17-5-6-18(24-15-17)26-20-23-10-7-19(27-20)30-21(31)25-16-22(30)8-3-2-4-9-22/h5-7,10,15H,2-4,8-9,11-14,16H2,1H3,(H,25,31)(H,23,24,26,27)
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n/an/a 4.98E+3n/an/an/an/an/an/a



G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
CDK6/CycD3


(Homo sapiens (Human))
BDBM443120
PNG
(US10654831, Compound 40)
Show SMILES C[C@H]1CNC(=O)CN1c1ccnc(Nc2ccc(cn2)N2CCN(C)CC2)n1
Show InChI InChI=1S/C19H26N8O/c1-14-11-22-18(28)13-27(14)17-5-6-20-19(24-17)23-16-4-3-15(12-21-16)26-9-7-25(2)8-10-26/h3-6,12,14H,7-11,13H2,1-2H3,(H,22,28)(H,20,21,23,24)/t14-/m0/s1
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n/an/a 5.70E+3n/an/an/an/an/an/a



G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 4 (CDK4)


(Homo sapiens (Human))
BDBM443116
PNG
(US10654831, Compound 16)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2CCNC2=O)nc1
Show InChI InChI=1S/C17H22N8O/c1-23-8-10-24(11-9-23)13-2-3-14(20-12-13)21-16-18-5-4-15(22-16)25-7-6-19-17(25)26/h2-5,12H,6-11H2,1H3,(H,19,26)(H,18,20,21,22)
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n/an/a 8.10E+3n/an/an/an/an/an/a



G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (Human))
BDBM443116
PNG
(US10654831, Compound 16)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2CCNC2=O)nc1
Show InChI InChI=1S/C17H22N8O/c1-23-8-10-24(11-9-23)13-2-3-14(20-12-13)21-16-18-5-4-15(22-16)25-7-6-19-17(25)26/h2-5,12H,6-11H2,1H3,(H,19,26)(H,18,20,21,22)
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n/an/a 9.30E+3n/an/an/an/an/an/a



G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (Human))
BDBM443113
PNG
(US10654831, Compound 6)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2C(=O)NCC22CCCCC2)nc1
Show InChI InChI=1S/C22H30N8O/c1-28-11-13-29(14-12-28)17-5-6-18(24-15-17)26-20-23-10-7-19(27-20)30-21(31)25-16-22(30)8-3-2-4-9-22/h5-7,10,15H,2-4,8-9,11-14,16H2,1H3,(H,25,31)(H,23,24,26,27)
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n/an/a 9.63E+3n/an/an/an/an/an/a



G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 2 (CDK2)


(Homo sapiens (Human))
BDBM443121
PNG
(US10654831, Compound 46)
Show SMILES CC(C)[C@H]1CNC(=O)N1c1ccnc(Nc2ccc(cn2)N2CCN(C)CC2)n1
Show InChI InChI=1S/C20H28N8O/c1-14(2)16-13-23-20(29)28(16)18-6-7-21-19(25-18)24-17-5-4-15(12-22-17)27-10-8-26(3)9-11-27/h4-7,12,14,16H,8-11,13H2,1-3H3,(H,23,29)(H,21,22,24,25)/t16-/m1/s1
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n/an/a 9.70E+3n/an/an/an/an/an/a



G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 4 (CDK4)


(Homo sapiens (Human))
BDBM443119
PNG
(US10654831, Compound 32)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2CCNC(=O)C2)nc1
Show InChI InChI=1S/C18H24N8O/c1-24-8-10-25(11-9-24)14-2-3-15(21-12-14)22-18-20-5-4-16(23-18)26-7-6-19-17(27)13-26/h2-5,12H,6-11,13H2,1H3,(H,19,27)(H,20,21,22,23)
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n/an/a 1.44E+4n/an/an/an/an/an/a



G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
CDK6/CycD3


(Homo sapiens (Human))
BDBM443114
PNG
(US10654831, Compound 8)
Show SMILES CN1CC2(CCCCC2)N(C1=O)c1ccnc(Nc2ccc(cn2)N2CCN(C)CC2)n1
Show InChI InChI=1S/C23H32N8O/c1-28-12-14-30(15-13-28)18-6-7-19(25-16-18)26-21-24-11-8-20(27-21)31-22(32)29(2)17-23(31)9-4-3-5-10-23/h6-8,11,16H,3-5,9-10,12-15,17H2,1-2H3,(H,24,25,26,27)
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US Patent
n/an/a 1.62E+4n/an/an/an/an/an/a



G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (Human))
BDBM443119
PNG
(US10654831, Compound 32)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2CCNC(=O)C2)nc1
Show InChI InChI=1S/C18H24N8O/c1-24-8-10-25(11-9-24)14-2-3-15(21-12-14)22-18-20-5-4-16(23-18)26-7-6-19-17(27)13-26/h2-5,12H,6-11,13H2,1H3,(H,19,27)(H,20,21,22,23)
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n/an/a 2.29E+4n/an/an/an/an/an/a



G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM443121
PNG
(US10654831, Compound 46)
Show SMILES CC(C)[C@H]1CNC(=O)N1c1ccnc(Nc2ccc(cn2)N2CCN(C)CC2)n1
Show InChI InChI=1S/C20H28N8O/c1-14(2)16-13-23-20(29)28(16)18-6-7-21-19(25-18)24-17-5-4-15(12-22-17)27-10-8-26(3)9-11-27/h4-7,12,14,16H,8-11,13H2,1-3H3,(H,23,29)(H,21,22,24,25)/t16-/m1/s1
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n/an/a 2.30E+4n/an/an/an/an/an/a



G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
CDK7/Cyclin H/MNAT1


(Homo sapiens (Human))
BDBM443116
PNG
(US10654831, Compound 16)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2CCNC2=O)nc1
Show InChI InChI=1S/C17H22N8O/c1-23-8-10-24(11-9-23)13-2-3-14(20-12-13)21-16-18-5-4-15(22-16)25-7-6-19-17(25)26/h2-5,12H,6-11H2,1H3,(H,19,26)(H,18,20,21,22)
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n/an/a 2.94E+4n/an/an/an/an/an/a



G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
CDK6/CycD3


(Homo sapiens (Human))
BDBM443126
PNG
(US10654831, Compound 56)
Show SMILES CC[C@H]1CC(=O)NN1c1ccnc(Nc2ccc(cn2)N2CCN(C)CC2)n1
Show InChI InChI=1S/C19H26N8O/c1-3-14-12-18(28)24-27(14)17-6-7-20-19(23-17)22-16-5-4-15(13-21-16)26-10-8-25(2)9-11-26/h4-7,13-14H,3,8-12H2,1-2H3,(H,24,28)(H,20,21,22,23)/t14-/m0/s1
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n/an/a 3.30E+4n/an/an/an/an/an/a



G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 2 (CDK2)


(Homo sapiens (Human))
BDBM443122
PNG
(US10654831, Compound 52)
Show SMILES C[C@H]1CNC(=O)N1c1ccnc(Nc2ccc(cn2)N2CCN(C)CC2)n1
Show InChI InChI=1S/C18H24N8O/c1-13-11-21-18(27)26(13)16-5-6-19-17(23-16)22-15-4-3-14(12-20-15)25-9-7-24(2)8-10-25/h3-6,12-13H,7-11H2,1-2H3,(H,21,27)(H,19,20,22,23)/t13-/m0/s1
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n/an/a 3.55E+4n/an/an/an/an/an/a



G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
CDK6/CycD3


(Homo sapiens (Human))
BDBM443115
PNG
(US10654831, Compound 10)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2C(=O)N(Cc3ccccc3)CC22CCCCC2)nc1
Show InChI InChI=1S/C29H36N8O/c1-34-16-18-35(19-17-34)24-10-11-25(31-20-24)32-27-30-15-12-26(33-27)37-28(38)36(21-23-8-4-2-5-9-23)22-29(37)13-6-3-7-14-29/h2,4-5,8-12,15,20H,3,6-7,13-14,16-19,21-22H2,1H3,(H,30,31,32,33)
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n/an/a 3.58E+4n/an/an/an/an/an/a



G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (Human))
BDBM443117
PNG
(US10654831, Compound 20)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2CC(=O)NCC22CCCCC2)nc1
Show InChI InChI=1S/C23H32N8O/c1-29-11-13-30(14-12-29)18-5-6-19(25-15-18)27-22-24-10-7-20(28-22)31-16-21(32)26-17-23(31)8-3-2-4-9-23/h5-7,10,15H,2-4,8-9,11-14,16-17H2,1H3,(H,26,32)(H,24,25,27,28)
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n/an/a 3.80E+4n/an/an/an/an/an/a



G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (Human))
BDBM443117
PNG
(US10654831, Compound 20)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2CC(=O)NCC22CCCCC2)nc1
Show InChI InChI=1S/C23H32N8O/c1-29-11-13-30(14-12-29)18-5-6-19(25-15-18)27-22-24-10-7-20(28-22)31-16-21(32)26-17-23(31)8-3-2-4-9-23/h5-7,10,15H,2-4,8-9,11-14,16-17H2,1H3,(H,26,32)(H,24,25,27,28)
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n/an/a 3.90E+4n/an/an/an/an/an/a



G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
CDK6/CycD3


(Homo sapiens (Human))
BDBM443119
PNG
(US10654831, Compound 32)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2CCNC(=O)C2)nc1
Show InChI InChI=1S/C18H24N8O/c1-24-8-10-25(11-9-24)14-2-3-15(21-12-14)22-18-20-5-4-16(23-18)26-7-6-19-17(27)13-26/h2-5,12H,6-11,13H2,1H3,(H,19,27)(H,20,21,22,23)
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n/an/a 5.10E+4n/an/an/an/an/an/a



G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM443122
PNG
(US10654831, Compound 52)
Show SMILES C[C@H]1CNC(=O)N1c1ccnc(Nc2ccc(cn2)N2CCN(C)CC2)n1
Show InChI InChI=1S/C18H24N8O/c1-13-11-21-18(27)26(13)16-5-6-19-17(23-16)22-15-4-3-14(12-20-15)25-9-7-24(2)8-10-25/h3-6,12-13H,7-11H2,1-2H3,(H,21,27)(H,19,20,22,23)/t13-/m0/s1
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n/an/a 5.70E+4n/an/an/an/an/an/a



G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM443120
PNG
(US10654831, Compound 40)
Show SMILES C[C@H]1CNC(=O)CN1c1ccnc(Nc2ccc(cn2)N2CCN(C)CC2)n1
Show InChI InChI=1S/C19H26N8O/c1-14-11-22-18(28)13-27(14)17-5-6-20-19(24-17)23-16-4-3-15(12-21-16)26-9-7-25(2)8-10-26/h3-6,12,14H,7-11,13H2,1-2H3,(H,22,28)(H,20,21,23,24)/t14-/m0/s1
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n/an/a 7.10E+4n/an/an/an/an/an/a



G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
CDK6/CycD3


(Homo sapiens (Human))
BDBM443123
PNG
(US10654831, Compound 53)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2C(=NCC22CCCCC2)c2ccccc2)nc1
Show InChI InChI=1S/C28H34N8/c1-34-16-18-35(19-17-34)23-10-11-24(30-20-23)32-27-29-15-12-25(33-27)36-26(22-8-4-2-5-9-22)31-21-28(36)13-6-3-7-14-28/h2,4-5,8-12,15,20H,3,6-7,13-14,16-19,21H2,1H3,(H,29,30,32,33)
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n/an/a 7.13E+4n/an/an/an/an/an/a



G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (Human))
BDBM443116
PNG
(US10654831, Compound 16)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2CCNC2=O)nc1
Show InChI InChI=1S/C17H22N8O/c1-23-8-10-24(11-9-23)13-2-3-14(20-12-13)21-16-18-5-4-15(22-16)25-7-6-19-17(25)26/h2-5,12H,6-11H2,1H3,(H,19,26)(H,18,20,21,22)
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n/an/a 7.30E+4n/an/an/an/an/an/a



G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 2 (CDK2)


(Homo sapiens (Human))
BDBM443120
PNG
(US10654831, Compound 40)
Show SMILES C[C@H]1CNC(=O)CN1c1ccnc(Nc2ccc(cn2)N2CCN(C)CC2)n1
Show InChI InChI=1S/C19H26N8O/c1-14-11-22-18(28)13-27(14)17-5-6-20-19(24-17)23-16-4-3-15(12-21-16)26-9-7-25(2)8-10-26/h3-6,12,14H,7-11,13H2,1-2H3,(H,22,28)(H,20,21,23,24)/t14-/m0/s1
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n/an/a 8.80E+4n/an/an/an/an/an/a



G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (Human))
BDBM443116
PNG
(US10654831, Compound 16)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2CCNC2=O)nc1
Show InChI InChI=1S/C17H22N8O/c1-23-8-10-24(11-9-23)13-2-3-14(20-12-13)21-16-18-5-4-15(22-16)25-7-6-19-17(25)26/h2-5,12H,6-11H2,1H3,(H,19,26)(H,18,20,21,22)
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n/an/a 9.50E+4n/an/an/an/an/an/a



G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
CDK7/Cyclin H/MNAT1


(Homo sapiens (Human))
BDBM443113
PNG
(US10654831, Compound 6)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2C(=O)NCC22CCCCC2)nc1
Show InChI InChI=1S/C22H30N8O/c1-28-11-13-29(14-12-28)17-5-6-18(24-15-17)26-20-23-10-7-19(27-20)30-21(31)25-16-22(30)8-3-2-4-9-22/h5-7,10,15H,2-4,8-9,11-14,16H2,1H3,(H,25,31)(H,23,24,26,27)
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n/an/a 9.59E+4n/an/an/an/an/an/a



G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (Human))
BDBM443125
PNG
(US10654831, Compound 55)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2C(=NCC22CCCCC2)c2ccsc2)nc1
Show InChI InChI=1S/C26H32N8S/c1-32-12-14-33(15-13-32)21-5-6-22(28-17-21)30-25-27-11-7-23(31-25)34-24(20-8-16-35-18-20)29-19-26(34)9-3-2-4-10-26/h5-8,11,16-18H,2-4,9-10,12-15,19H2,1H3,(H,27,28,30,31)
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n/an/a>1.00E+5n/an/an/an/an/an/a



G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM443126
PNG
(US10654831, Compound 56)
Show SMILES CC[C@H]1CC(=O)NN1c1ccnc(Nc2ccc(cn2)N2CCN(C)CC2)n1
Show InChI InChI=1S/C19H26N8O/c1-3-14-12-18(28)24-27(14)17-6-7-20-19(23-17)22-16-5-4-15(13-21-16)26-10-8-25(2)9-11-26/h4-7,13-14H,3,8-12H2,1-2H3,(H,24,28)(H,20,21,22,23)/t14-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM443113
PNG
(US10654831, Compound 6)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2C(=O)NCC22CCCCC2)nc1
Show InChI InChI=1S/C22H30N8O/c1-28-11-13-29(14-12-28)17-5-6-18(24-15-17)26-20-23-10-7-19(27-20)30-21(31)25-16-22(30)8-3-2-4-9-22/h5-7,10,15H,2-4,8-9,11-14,16H2,1H3,(H,25,31)(H,23,24,26,27)
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n/an/a>1.00E+5n/an/an/an/an/an/a



G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM443115
PNG
(US10654831, Compound 10)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2C(=O)N(Cc3ccccc3)CC22CCCCC2)nc1
Show InChI InChI=1S/C29H36N8O/c1-34-16-18-35(19-17-34)24-10-11-25(31-20-24)32-27-30-15-12-26(33-27)37-28(38)36(21-23-8-4-2-5-9-23)22-29(37)13-6-3-7-14-29/h2,4-5,8-12,15,20H,3,6-7,13-14,16-19,21-22H2,1H3,(H,30,31,32,33)
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G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 2 (CDK2)


(Homo sapiens (Human))
BDBM443115
PNG
(US10654831, Compound 10)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2C(=O)N(Cc3ccccc3)CC22CCCCC2)nc1
Show InChI InChI=1S/C29H36N8O/c1-34-16-18-35(19-17-34)24-10-11-25(31-20-24)32-27-30-15-12-26(33-27)37-28(38)36(21-23-8-4-2-5-9-23)22-29(37)13-6-3-7-14-29/h2,4-5,8-12,15,20H,3,6-7,13-14,16-19,21-22H2,1H3,(H,30,31,32,33)
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n/an/a>1.00E+5n/an/an/an/an/an/a



G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (Human))
BDBM443115
PNG
(US10654831, Compound 10)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2C(=O)N(Cc3ccccc3)CC22CCCCC2)nc1
Show InChI InChI=1S/C29H36N8O/c1-34-16-18-35(19-17-34)24-10-11-25(31-20-24)32-27-30-15-12-26(33-27)37-28(38)36(21-23-8-4-2-5-9-23)22-29(37)13-6-3-7-14-29/h2,4-5,8-12,15,20H,3,6-7,13-14,16-19,21-22H2,1H3,(H,30,31,32,33)
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G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 2 (CDK2)


(Homo sapiens (Human))
BDBM443117
PNG
(US10654831, Compound 20)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2CC(=O)NCC22CCCCC2)nc1
Show InChI InChI=1S/C23H32N8O/c1-29-11-13-30(14-12-29)18-5-6-19(25-15-18)27-22-24-10-7-20(28-22)31-16-21(32)26-17-23(31)8-3-2-4-9-23/h5-7,10,15H,2-4,8-9,11-14,16-17H2,1H3,(H,26,32)(H,24,25,27,28)
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G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 4 (CDK4)


(Homo sapiens (Human))
BDBM443123
PNG
(US10654831, Compound 53)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2C(=NCC22CCCCC2)c2ccccc2)nc1
Show InChI InChI=1S/C28H34N8/c1-34-16-18-35(19-17-34)23-10-11-24(30-20-23)32-27-29-15-12-25(33-27)36-26(22-8-4-2-5-9-22)31-21-28(36)13-6-3-7-14-28/h2,4-5,8-12,15,20H,3,6-7,13-14,16-19,21H2,1H3,(H,29,30,32,33)
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G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 2 (CDK2)


(Homo sapiens (Human))
BDBM443123
PNG
(US10654831, Compound 53)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2C(=NCC22CCCCC2)c2ccccc2)nc1
Show InChI InChI=1S/C28H34N8/c1-34-16-18-35(19-17-34)23-10-11-24(30-20-23)32-27-29-15-12-25(33-27)36-26(22-8-4-2-5-9-22)31-21-28(36)13-6-3-7-14-28/h2,4-5,8-12,15,20H,3,6-7,13-14,16-19,21H2,1H3,(H,29,30,32,33)
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G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (Human))
BDBM443124
PNG
(US10654831, Compound 54)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2C(=NCC22CCCCC2)c2ccoc2)nc1
Show InChI InChI=1S/C26H32N8O/c1-32-12-14-33(15-13-32)21-5-6-22(28-17-21)30-25-27-11-7-23(31-25)34-24(20-8-16-35-18-20)29-19-26(34)9-3-2-4-10-26/h5-8,11,16-18H,2-4,9-10,12-15,19H2,1H3,(H,27,28,30,31)
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G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 2 (CDK2)


(Homo sapiens (Human))
BDBM443116
PNG
(US10654831, Compound 16)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2CCNC2=O)nc1
Show InChI InChI=1S/C17H22N8O/c1-23-8-10-24(11-9-23)13-2-3-14(20-12-13)21-16-18-5-4-15(22-16)25-7-6-19-17(25)26/h2-5,12H,6-11H2,1H3,(H,19,26)(H,18,20,21,22)
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G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM443124
PNG
(US10654831, Compound 54)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2C(=NCC22CCCCC2)c2ccoc2)nc1
Show InChI InChI=1S/C26H32N8O/c1-32-12-14-33(15-13-32)21-5-6-22(28-17-21)30-25-27-11-7-23(31-25)34-24(20-8-16-35-18-20)29-19-26(34)9-3-2-4-10-26/h5-8,11,16-18H,2-4,9-10,12-15,19H2,1H3,(H,27,28,30,31)
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G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 4 (CDK4)


(Homo sapiens (Human))
BDBM443125
PNG
(US10654831, Compound 55)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2C(=NCC22CCCCC2)c2ccsc2)nc1
Show InChI InChI=1S/C26H32N8S/c1-32-12-14-33(15-13-32)21-5-6-22(28-17-21)30-25-27-11-7-23(31-25)34-24(20-8-16-35-18-20)29-19-26(34)9-3-2-4-10-26/h5-8,11,16-18H,2-4,9-10,12-15,19H2,1H3,(H,27,28,30,31)
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G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 2 (CDK2)


(Homo sapiens (Human))
BDBM443126
PNG
(US10654831, Compound 56)
Show SMILES CC[C@H]1CC(=O)NN1c1ccnc(Nc2ccc(cn2)N2CCN(C)CC2)n1
Show InChI InChI=1S/C19H26N8O/c1-3-14-12-18(28)24-27(14)17-6-7-20-19(23-17)22-16-5-4-15(13-21-16)26-10-8-25(2)9-11-26/h4-7,13-14H,3,8-12H2,1-2H3,(H,24,28)(H,20,21,22,23)/t14-/m0/s1
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G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
CDK7/Cyclin H/MNAT1


(Homo sapiens (Human))
BDBM443114
PNG
(US10654831, Compound 8)
Show SMILES CN1CC2(CCCCC2)N(C1=O)c1ccnc(Nc2ccc(cn2)N2CCN(C)CC2)n1
Show InChI InChI=1S/C23H32N8O/c1-28-12-14-30(15-13-28)18-6-7-19(25-16-18)26-21-24-11-8-20(27-21)31-22(32)29(2)17-23(31)9-4-3-5-10-23/h6-8,11,16H,3-5,9-10,12-15,17H2,1-2H3,(H,24,25,26,27)
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G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
CDK7/Cyclin H/MNAT1


(Homo sapiens (Human))
BDBM443125
PNG
(US10654831, Compound 55)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2C(=NCC22CCCCC2)c2ccsc2)nc1
Show InChI InChI=1S/C26H32N8S/c1-32-12-14-33(15-13-32)21-5-6-22(28-17-21)30-25-27-11-7-23(31-25)34-24(20-8-16-35-18-20)29-19-26(34)9-3-2-4-10-26/h5-8,11,16-18H,2-4,9-10,12-15,19H2,1H3,(H,27,28,30,31)
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G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 4 (CDK4)


(Homo sapiens (Human))
BDBM443118
PNG
(US10654831, Compound 28)
Show SMILES CC(C)C1CC(=O)NN1c1ccnc(Nc2ccc(cn2)N2CCN(C)CC2)n1
Show InChI InChI=1S/C20H28N8O/c1-14(2)16-12-19(29)25-28(16)18-6-7-21-20(24-18)23-17-5-4-15(13-22-17)27-10-8-26(3)9-11-27/h4-7,13-14,16H,8-12H2,1-3H3,(H,25,29)(H,21,22,23,24)
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G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 2 (CDK2)


(Homo sapiens (Human))
BDBM443124
PNG
(US10654831, Compound 54)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2C(=NCC22CCCCC2)c2ccoc2)nc1
Show InChI InChI=1S/C26H32N8O/c1-32-12-14-33(15-13-32)21-5-6-22(28-17-21)30-25-27-11-7-23(31-25)34-24(20-8-16-35-18-20)29-19-26(34)9-3-2-4-10-26/h5-8,11,16-18H,2-4,9-10,12-15,19H2,1H3,(H,27,28,30,31)
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G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM443125
PNG
(US10654831, Compound 55)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2C(=NCC22CCCCC2)c2ccsc2)nc1
Show InChI InChI=1S/C26H32N8S/c1-32-12-14-33(15-13-32)21-5-6-22(28-17-21)30-25-27-11-7-23(31-25)34-24(20-8-16-35-18-20)29-19-26(34)9-3-2-4-10-26/h5-8,11,16-18H,2-4,9-10,12-15,19H2,1H3,(H,27,28,30,31)
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G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 2 (CDK2)


(Homo sapiens (Human))
BDBM443125
PNG
(US10654831, Compound 55)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2C(=NCC22CCCCC2)c2ccsc2)nc1
Show InChI InChI=1S/C26H32N8S/c1-32-12-14-33(15-13-32)21-5-6-22(28-17-21)30-25-27-11-7-23(31-25)34-24(20-8-16-35-18-20)29-19-26(34)9-3-2-4-10-26/h5-8,11,16-18H,2-4,9-10,12-15,19H2,1H3,(H,27,28,30,31)
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G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (Human))
BDBM443113
PNG
(US10654831, Compound 6)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2C(=O)NCC22CCCCC2)nc1
Show InChI InChI=1S/C22H30N8O/c1-28-11-13-29(14-12-28)17-5-6-18(24-15-17)26-20-23-10-7-19(27-20)30-21(31)25-16-22(30)8-3-2-4-9-22/h5-7,10,15H,2-4,8-9,11-14,16H2,1H3,(H,25,31)(H,23,24,26,27)
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G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (Human))
BDBM443124
PNG
(US10654831, Compound 54)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2C(=NCC22CCCCC2)c2ccoc2)nc1
Show InChI InChI=1S/C26H32N8O/c1-32-12-14-33(15-13-32)21-5-6-22(28-17-21)30-25-27-11-7-23(31-25)34-24(20-8-16-35-18-20)29-19-26(34)9-3-2-4-10-26/h5-8,11,16-18H,2-4,9-10,12-15,19H2,1H3,(H,27,28,30,31)
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G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (Human))
BDBM443125
PNG
(US10654831, Compound 55)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2C(=NCC22CCCCC2)c2ccsc2)nc1
Show InChI InChI=1S/C26H32N8S/c1-32-12-14-33(15-13-32)21-5-6-22(28-17-21)30-25-27-11-7-23(31-25)34-24(20-8-16-35-18-20)29-19-26(34)9-3-2-4-10-26/h5-8,11,16-18H,2-4,9-10,12-15,19H2,1H3,(H,27,28,30,31)
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G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM443117
PNG
(US10654831, Compound 20)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2CC(=O)NCC22CCCCC2)nc1
Show InChI InChI=1S/C23H32N8O/c1-29-11-13-30(14-12-29)18-5-6-19(25-15-18)27-22-24-10-7-20(28-22)31-16-21(32)26-17-23(31)8-3-2-4-9-23/h5-7,10,15H,2-4,8-9,11-14,16-17H2,1H3,(H,26,32)(H,24,25,27,28)
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n/an/a>1.00E+5n/an/an/an/an/an/a



G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
CDK6/CycD3


(Homo sapiens (Human))
BDBM443124
PNG
(US10654831, Compound 54)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2C(=NCC22CCCCC2)c2ccoc2)nc1
Show InChI InChI=1S/C26H32N8O/c1-32-12-14-33(15-13-32)21-5-6-22(28-17-21)30-25-27-11-7-23(31-25)34-24(20-8-16-35-18-20)29-19-26(34)9-3-2-4-10-26/h5-8,11,16-18H,2-4,9-10,12-15,19H2,1H3,(H,27,28,30,31)
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n/an/a>1.00E+5n/an/an/an/an/an/a



G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (Human))
BDBM443114
PNG
(US10654831, Compound 8)
Show SMILES CN1CC2(CCCCC2)N(C1=O)c1ccnc(Nc2ccc(cn2)N2CCN(C)CC2)n1
Show InChI InChI=1S/C23H32N8O/c1-28-12-14-30(15-13-28)18-6-7-19(25-16-18)26-21-24-11-8-20(27-21)31-22(32)29(2)17-23(31)9-4-3-5-10-23/h6-8,11,16H,3-5,9-10,12-15,17H2,1-2H3,(H,24,25,26,27)
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G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (Human))
BDBM443115
PNG
(US10654831, Compound 10)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2C(=O)N(Cc3ccccc3)CC22CCCCC2)nc1
Show InChI InChI=1S/C29H36N8O/c1-34-16-18-35(19-17-34)24-10-11-25(31-20-24)32-27-30-15-12-26(33-27)37-28(38)36(21-23-8-4-2-5-9-23)22-29(37)13-6-3-7-14-29/h2,4-5,8-12,15,20H,3,6-7,13-14,16-19,21-22H2,1H3,(H,30,31,32,33)
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G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
CDK7/Cyclin H/MNAT1


(Homo sapiens (Human))
BDBM443117
PNG
(US10654831, Compound 20)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2CC(=O)NCC22CCCCC2)nc1
Show InChI InChI=1S/C23H32N8O/c1-29-11-13-30(14-12-29)18-5-6-19(25-15-18)27-22-24-10-7-20(28-22)31-16-21(32)26-17-23(31)8-3-2-4-9-23/h5-7,10,15H,2-4,8-9,11-14,16-17H2,1H3,(H,26,32)(H,24,25,27,28)
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G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
CDK7/Cyclin H/MNAT1


(Homo sapiens (Human))
BDBM443124
PNG
(US10654831, Compound 54)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2C(=NCC22CCCCC2)c2ccoc2)nc1
Show InChI InChI=1S/C26H32N8O/c1-32-12-14-33(15-13-32)21-5-6-22(28-17-21)30-25-27-11-7-23(31-25)34-24(20-8-16-35-18-20)29-19-26(34)9-3-2-4-10-26/h5-8,11,16-18H,2-4,9-10,12-15,19H2,1H3,(H,27,28,30,31)
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G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM443123
PNG
(US10654831, Compound 53)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2C(=NCC22CCCCC2)c2ccccc2)nc1
Show InChI InChI=1S/C28H34N8/c1-34-16-18-35(19-17-34)23-10-11-24(30-20-23)32-27-29-15-12-25(33-27)36-26(22-8-4-2-5-9-22)31-21-28(36)13-6-3-7-14-28/h2,4-5,8-12,15,20H,3,6-7,13-14,16-19,21H2,1H3,(H,29,30,32,33)
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G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (Human))
BDBM443123
PNG
(US10654831, Compound 53)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2C(=NCC22CCCCC2)c2ccccc2)nc1
Show InChI InChI=1S/C28H34N8/c1-34-16-18-35(19-17-34)23-10-11-24(30-20-23)32-27-29-15-12-25(33-27)36-26(22-8-4-2-5-9-22)31-21-28(36)13-6-3-7-14-28/h2,4-5,8-12,15,20H,3,6-7,13-14,16-19,21H2,1H3,(H,29,30,32,33)
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G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
CDK7/Cyclin H/MNAT1


(Homo sapiens (Human))
BDBM443123
PNG
(US10654831, Compound 53)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2C(=NCC22CCCCC2)c2ccccc2)nc1
Show InChI InChI=1S/C28H34N8/c1-34-16-18-35(19-17-34)23-10-11-24(30-20-23)32-27-29-15-12-25(33-27)36-26(22-8-4-2-5-9-22)31-21-28(36)13-6-3-7-14-28/h2,4-5,8-12,15,20H,3,6-7,13-14,16-19,21H2,1H3,(H,29,30,32,33)
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G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (Human))
BDBM443113
PNG
(US10654831, Compound 6)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2C(=O)NCC22CCCCC2)nc1
Show InChI InChI=1S/C22H30N8O/c1-28-11-13-29(14-12-28)17-5-6-18(24-15-17)26-20-23-10-7-19(27-20)30-21(31)25-16-22(30)8-3-2-4-9-22/h5-7,10,15H,2-4,8-9,11-14,16H2,1H3,(H,25,31)(H,23,24,26,27)
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G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM443116
PNG
(US10654831, Compound 16)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2CCNC2=O)nc1
Show InChI InChI=1S/C17H22N8O/c1-23-8-10-24(11-9-23)13-2-3-14(20-12-13)21-16-18-5-4-15(22-16)25-7-6-19-17(25)26/h2-5,12H,6-11H2,1H3,(H,19,26)(H,18,20,21,22)
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G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (Human))
BDBM443123
PNG
(US10654831, Compound 53)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2C(=NCC22CCCCC2)c2ccccc2)nc1
Show InChI InChI=1S/C28H34N8/c1-34-16-18-35(19-17-34)23-10-11-24(30-20-23)32-27-29-15-12-25(33-27)36-26(22-8-4-2-5-9-22)31-21-28(36)13-6-3-7-14-28/h2,4-5,8-12,15,20H,3,6-7,13-14,16-19,21H2,1H3,(H,29,30,32,33)
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G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (Human))
BDBM443124
PNG
(US10654831, Compound 54)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2C(=NCC22CCCCC2)c2ccoc2)nc1
Show InChI InChI=1S/C26H32N8O/c1-32-12-14-33(15-13-32)21-5-6-22(28-17-21)30-25-27-11-7-23(31-25)34-24(20-8-16-35-18-20)29-19-26(34)9-3-2-4-10-26/h5-8,11,16-18H,2-4,9-10,12-15,19H2,1H3,(H,27,28,30,31)
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G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (Human))
BDBM443114
PNG
(US10654831, Compound 8)
Show SMILES CN1CC2(CCCCC2)N(C1=O)c1ccnc(Nc2ccc(cn2)N2CCN(C)CC2)n1
Show InChI InChI=1S/C23H32N8O/c1-28-12-14-30(15-13-28)18-6-7-19(25-16-18)26-21-24-11-8-20(27-21)31-22(32)29(2)17-23(31)9-4-3-5-10-23/h6-8,11,16H,3-5,9-10,12-15,17H2,1-2H3,(H,24,25,26,27)
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G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (Human))
BDBM443125
PNG
(US10654831, Compound 55)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2C(=NCC22CCCCC2)c2ccsc2)nc1
Show InChI InChI=1S/C26H32N8S/c1-32-12-14-33(15-13-32)21-5-6-22(28-17-21)30-25-27-11-7-23(31-25)34-24(20-8-16-35-18-20)29-19-26(34)9-3-2-4-10-26/h5-8,11,16-18H,2-4,9-10,12-15,19H2,1H3,(H,27,28,30,31)
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G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 2 (CDK2)


(Homo sapiens (Human))
BDBM443113
PNG
(US10654831, Compound 6)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2C(=O)NCC22CCCCC2)nc1
Show InChI InChI=1S/C22H30N8O/c1-28-11-13-29(14-12-28)17-5-6-18(24-15-17)26-20-23-10-7-19(27-20)30-21(31)25-16-22(30)8-3-2-4-9-22/h5-7,10,15H,2-4,8-9,11-14,16H2,1H3,(H,25,31)(H,23,24,26,27)
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G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM443114
PNG
(US10654831, Compound 8)
Show SMILES CN1CC2(CCCCC2)N(C1=O)c1ccnc(Nc2ccc(cn2)N2CCN(C)CC2)n1
Show InChI InChI=1S/C23H32N8O/c1-28-12-14-30(15-13-28)18-6-7-19(25-16-18)26-21-24-11-8-20(27-21)31-22(32)29(2)17-23(31)9-4-3-5-10-23/h6-8,11,16H,3-5,9-10,12-15,17H2,1-2H3,(H,24,25,26,27)
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G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 2 (CDK2)


(Homo sapiens (Human))
BDBM443114
PNG
(US10654831, Compound 8)
Show SMILES CN1CC2(CCCCC2)N(C1=O)c1ccnc(Nc2ccc(cn2)N2CCN(C)CC2)n1
Show InChI InChI=1S/C23H32N8O/c1-28-12-14-30(15-13-28)18-6-7-19(25-16-18)26-21-24-11-8-20(27-21)31-22(32)29(2)17-23(31)9-4-3-5-10-23/h6-8,11,16H,3-5,9-10,12-15,17H2,1-2H3,(H,24,25,26,27)
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G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (Human))
BDBM443114
PNG
(US10654831, Compound 8)
Show SMILES CN1CC2(CCCCC2)N(C1=O)c1ccnc(Nc2ccc(cn2)N2CCN(C)CC2)n1
Show InChI InChI=1S/C23H32N8O/c1-28-12-14-30(15-13-28)18-6-7-19(25-16-18)26-21-24-11-8-20(27-21)31-22(32)29(2)17-23(31)9-4-3-5-10-23/h6-8,11,16H,3-5,9-10,12-15,17H2,1-2H3,(H,24,25,26,27)
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n/an/a>1.00E+5n/an/an/an/an/an/a



G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
CDK6/CycD3


(Homo sapiens (Human))
BDBM443125
PNG
(US10654831, Compound 55)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2C(=NCC22CCCCC2)c2ccsc2)nc1
Show InChI InChI=1S/C26H32N8S/c1-32-12-14-33(15-13-32)21-5-6-22(28-17-21)30-25-27-11-7-23(31-25)34-24(20-8-16-35-18-20)29-19-26(34)9-3-2-4-10-26/h5-8,11,16-18H,2-4,9-10,12-15,19H2,1H3,(H,27,28,30,31)
PDB

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n/an/a>1.00E+5n/an/an/an/an/an/a



G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
CDK7/Cyclin H/MNAT1


(Homo sapiens (Human))
BDBM443115
PNG
(US10654831, Compound 10)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2C(=O)N(Cc3ccccc3)CC22CCCCC2)nc1
Show InChI InChI=1S/C29H36N8O/c1-34-16-18-35(19-17-34)24-10-11-25(31-20-24)32-27-30-15-12-26(33-27)37-28(38)36(21-23-8-4-2-5-9-23)22-29(37)13-6-3-7-14-29/h2,4-5,8-12,15,20H,3,6-7,13-14,16-19,21-22H2,1H3,(H,30,31,32,33)
PDB

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n/an/a>1.00E+5n/an/an/an/an/an/a



G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (Human))
BDBM443115
PNG
(US10654831, Compound 10)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2C(=O)N(Cc3ccccc3)CC22CCCCC2)nc1
Show InChI InChI=1S/C29H36N8O/c1-34-16-18-35(19-17-34)24-10-11-25(31-20-24)32-27-30-15-12-26(33-27)37-28(38)36(21-23-8-4-2-5-9-23)22-29(37)13-6-3-7-14-29/h2,4-5,8-12,15,20H,3,6-7,13-14,16-19,21-22H2,1H3,(H,30,31,32,33)
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G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (Human))
BDBM443123
PNG
(US10654831, Compound 53)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2C(=NCC22CCCCC2)c2ccccc2)nc1
Show InChI InChI=1S/C28H34N8/c1-34-16-18-35(19-17-34)23-10-11-24(30-20-23)32-27-29-15-12-25(33-27)36-26(22-8-4-2-5-9-22)31-21-28(36)13-6-3-7-14-28/h2,4-5,8-12,15,20H,3,6-7,13-14,16-19,21H2,1H3,(H,29,30,32,33)
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G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
CDK6/CycD3


(Homo sapiens (Human))
BDBM443118
PNG
(US10654831, Compound 28)
Show SMILES CC(C)C1CC(=O)NN1c1ccnc(Nc2ccc(cn2)N2CCN(C)CC2)n1
Show InChI InChI=1S/C20H28N8O/c1-14(2)16-12-19(29)25-28(16)18-6-7-21-20(24-18)23-17-5-4-15(13-22-17)27-10-8-26(3)9-11-27/h4-7,13-14,16H,8-12H2,1-3H3,(H,25,29)(H,21,22,23,24)
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n/an/a>1.00E+5n/an/an/an/an/an/a



G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 4 (CDK4)


(Homo sapiens (Human))
BDBM443124
PNG
(US10654831, Compound 54)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2C(=NCC22CCCCC2)c2ccoc2)nc1
Show InChI InChI=1S/C26H32N8O/c1-32-12-14-33(15-13-32)21-5-6-22(28-17-21)30-25-27-11-7-23(31-25)34-24(20-8-16-35-18-20)29-19-26(34)9-3-2-4-10-26/h5-8,11,16-18H,2-4,9-10,12-15,19H2,1H3,(H,27,28,30,31)
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G1 Therapeutics, Inc.

US Patent


Assay Description
Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...


US Patent US10654831 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%