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Patent code US10654853

Compile Data Set for Download or QSAR
Found 147 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
OTU domain-containing protein 7B


(Human)
BDBM443363
PNG
(7-(1-Methyl-1H-indazol- 4-yl)-2-oxo-1,2- dihydrosp...)
Show SMILES Cn1ncc2c(cccc12)-c1cnc2OC3(CCN(C3)C#N)C(=O)Nc2c1
Show InChI InChI=1S/C19H16N6O2/c1-24-16-4-2-3-13(14(16)9-22-24)12-7-15-17(21-8-12)27-19(18(26)23-15)5-6-25(10-19)11-20/h2-4,7-9H,5-6,10H2,1H3,(H,23,26)
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n/an/a<100n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443372
PNG
(7-(5-Methyl-1H- indazol-4-yl)-2- oxo-1,4-dihydro- ...)
Show SMILES Cc1ccc2[nH]ncc2c1-c1cnc2NC3(CCN(C3)C#N)C(=O)Nc2c1
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n/an/a<100n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443364
PNG
(7-(1-(2-Hydroxyethyl)- 1H-indazol-4-yl)-2- oxo-1,2...)
Show SMILES CCn1ncc2c(cccc12)-c1cnc2OC3(CCN(C3)C#N)C(=O)Nc2c1
Show InChI InChI=1S/C20H18N6O2/c1-2-26-17-5-3-4-14(15(17)10-23-26)13-8-16-18(22-9-13)28-20(19(27)24-16)6-7-25(11-20)12-21/h3-5,8-10H,2,6-7,11H2,1H3,(H,24,27)
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n/an/a<100n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443362
PNG
(7-(1H-Indazol-4-yl)-2- oxo-1,2-dihydrospiro [pyrid...)
Show SMILES O=C1Nc2cc(cnc2OC11CCN(C1)C#N)-c1cccc2[nH]ncc12
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n/an/a<100n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443251
PNG
(7'-(1-Methyl-1H-indazol-5-yl)- 2'-oxo-1',4'-dihydr...)
Show SMILES Cn1ncc2cc(ccc12)-c1ccc2CC3(CCN(C3)C#N)C(=O)Nc2c1
Show InChI InChI=1S/C21H19N5O/c1-25-19-5-4-14(8-17(19)11-23-25)15-2-3-16-10-21(6-7-26(12-21)13-22)20(27)24-18(16)9-15/h2-5,8-9,11H,6-7,10,12H2,1H3,(H,24,27)
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n/an/a<100n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443287
PNG
(US10654853, Example 60)
Show SMILES Fc1cccc(c1)-c1cnc2NC3(CCN(C3)C#N)C(=O)Nc2c1
Show InChI InChI=1S/C17H14FN5O/c18-13-3-1-2-11(6-13)12-7-14-15(20-8-12)22-17(16(24)21-14)4-5-23(9-17)10-19/h1-3,6-8H,4-5,9H2,(H,20,22)(H,21,24)
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443346
PNG
(N-(2-(1-Cyano-2'-oxo-1',4'-dihydro- 2'H-spiro[pyrr...)
Show SMILES CC(=O)Nc1ccccc1-c1ccc2NC(=O)C3(CCN(C3)C#N)Cc2c1
Show InChI InChI=1S/C21H20N4O2/c1-14(26)23-19-5-3-2-4-17(19)15-6-7-18-16(10-15)11-21(20(27)24-18)8-9-25(12-21)13-22/h2-7,10H,8-9,11-12H2,1H3,(H,23,26)(H,24,27)
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443370
PNG
(1′-Cyano-2-oxo-N-phenyl-1,2-dihydrospiro[pyr...)
Show SMILES O=C(Nc1ccccc1)c1ccc2NC(=O)C3(CCN(C3)C#N)Oc2n1
Show InChI InChI=1S/C18H15N5O3/c19-11-23-9-8-18(10-23)17(25)22-14-7-6-13(21-16(14)26-18)15(24)20-12-4-2-1-3-5-12/h1-7H,8-10H2,(H,20,24)(H,22,25)
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443246
PNG
(7'-(4-(4-Methylpiperazin-1- yl)phenyl)-2'-oxo-1',4...)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2CC3(CCN(C3)C#N)C(=O)Nc2c1
Show InChI InChI=1S/C24H27N5O/c1-27-10-12-29(13-11-27)21-6-4-18(5-7-21)19-2-3-20-15-24(8-9-28(16-24)17-25)23(30)26-22(20)14-19/h2-7,14H,8-13,15-16H2,1H3,(H,26,30)
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443255
PNG
(2'-Oxo-7'-(pyrimidin-5-yl)- 1',4'-dihydro-2'H- spi...)
Show SMILES O=C1Nc2cc(ccc2CC11CCN(C1)C#N)-c1cncnc1
Show InChI InChI=1S/C17H15N5O/c18-10-22-4-3-17(9-22)6-13-2-1-12(5-15(13)21-16(17)23)14-7-19-11-20-8-14/h1-2,5,7-8,11H,3-4,6,9H2,(H,21,23)
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443268
PNG
(US10654853, Example 41 | US10654853, Example 44)
Show SMILES O=C1Nc2ccc(cc2CC11CCN(C1)C#N)-c1ccccc1
Show InChI InChI=1S/C19H17N3O/c20-13-22-9-8-19(12-22)11-16-10-15(14-4-2-1-3-5-14)6-7-17(16)21-18(19)23/h1-7,10H,8-9,11-12H2,(H,21,23)
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443268
PNG
(US10654853, Example 41 | US10654853, Example 44)
Show SMILES O=C1Nc2ccc(cc2CC11CCN(C1)C#N)-c1ccccc1
Show InChI InChI=1S/C19H17N3O/c20-13-22-9-8-19(12-22)11-16-10-15(14-4-2-1-3-5-14)6-7-17(16)21-18(19)23/h1-7,10H,8-9,11-12H2,(H,21,23)
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443299
PNG
((S)-7-(4- Fluorophenyl)- 2-oxo-1,4- dihydro-2H- sp...)
Show SMILES Fc1ccc(cc1)-c1cnc2N[C@]3(CCN(C3)C#N)C(=O)Nc2c1
Show InChI InChI=1S/C17H14FN5O/c18-13-3-1-11(2-4-13)12-7-14-15(20-8-12)22-17(16(24)21-14)5-6-23(9-17)10-19/h1-4,7-8H,5-6,9H2,(H,20,22)(H,21,24)/t17-/m0/s1
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443300
PNG
((S)-7-(3- Fluorophenyl)- 2-oxo- 1,4-dihydro- 2H-sp...)
Show SMILES Fc1cccc(c1)-c1cnc2N[C@]3(CCN(C3)C#N)C(=O)Nc2c1
Show InChI InChI=1S/C17H14FN5O/c18-13-3-1-2-11(6-13)12-7-14-15(20-8-12)22-17(16(24)21-14)4-5-23(9-17)10-19/h1-3,6-8H,4-5,9H2,(H,20,22)(H,21,24)/t17-/m0/s1
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443314
PNG
(8-Methyl-7,10-dioxo-8-phenyl-2,6,9-triazaspiro[4.5...)
Show SMILES CC1(NC(=O)C2(CCN(C2)C#N)NC1=O)c1ccccc1
Show InChI InChI=1S/C15H16N4O2/c1-14(11-5-3-2-4-6-11)12(20)18-15(13(21)17-14)7-8-19(9-15)10-16/h2-6H,7-9H2,1H3,(H,17,21)(H,18,20)
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443321
PNG
(6'-(1-Methyl-1H-pyrazol-5-yl)-2'-oxo- 1',4'-dihydr...)
Show SMILES Cn1nccc1-c1ccc2NC(=O)C3(CCN(C3)C#N)Cc2c1
Show InChI InChI=1S/C17H17N5O/c1-21-15(4-6-19-21)12-2-3-14-13(8-12)9-17(16(23)20-14)5-7-22(10-17)11-18/h2-4,6,8H,5,7,9-10H2,1H3,(H,20,23)
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443348
PNG
(6'-(3-(Morpholinosulfonyl)phenyl)-2'- oxo-1',4'-di...)
Show SMILES O=C1Nc2ccc(cc2CC11CCN(C1)C#N)-c1cccc(c1)S(=O)(=O)N1CCOCC1
Show InChI InChI=1S/C23H24N4O4S/c24-16-26-7-6-23(15-26)14-19-12-18(4-5-21(19)25-22(23)28)17-2-1-3-20(13-17)32(29,30)27-8-10-31-11-9-27/h1-5,12-13H,6-11,14-15H2,(H,25,28)
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443353
PNG
(6'-(4-(4-Methylpiperazin-1-yl)phenyl)- 2'-oxo-1',4...)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2NC(=O)C3(CCN(C3)C#N)Cc2c1
Show InChI InChI=1S/C24H27N5O/c1-27-10-12-29(13-11-27)21-5-2-18(3-6-21)19-4-7-22-20(14-19)15-24(23(30)26-22)8-9-28(16-24)17-25/h2-7,14H,8-13,15-16H2,1H3,(H,26,30)
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443356
PNG
(6'-(4-(Morpholinomethyl)phenyl)-2'- oxo-1',4'-dihy...)
Show SMILES O=C1Nc2ccc(cc2CC11CCN(C1)C#N)-c1ccc(CN2CCOCC2)cc1
Show InChI InChI=1S/C24H26N4O2/c25-17-28-8-7-24(16-28)14-21-13-20(5-6-22(21)26-23(24)29)19-3-1-18(2-4-19)15-27-9-11-30-12-10-27/h1-6,13H,7-12,14-16H2,(H,26,29)
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443365
PNG
(7-(6-Methoxy-2- methylpyridin-3-yl)- 2-oxo-1,2-dih...)
Show SMILES COc1ccc(c(C)n1)-c1cnc2OC3(CCN(C3)C#N)C(=O)Nc2c1
Show InChI InChI=1S/C18H17N5O3/c1-11-13(3-4-15(21-11)25-2)12-7-14-16(20-8-12)26-18(17(24)22-14)5-6-23(9-18)10-19/h3-4,7-8H,5-6,9H2,1-2H3,(H,22,24)
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443367
PNG
(7-(1-(2-Methoxyethyl)-1H-indazol-4-yl)-2-oxo-1,2-d...)
Show SMILES COCCn1ncc2c(cccc12)-c1cnc2OC3(CCN(C3)C#N)C(=O)Nc2c1
Show InChI InChI=1S/C21H20N6O3/c1-29-8-7-27-18-4-2-3-15(16(18)11-24-27)14-9-17-19(23-10-14)30-21(20(28)25-17)5-6-26(12-21)13-22/h2-4,9-11H,5-8,12H2,1H3,(H,25,28)
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443276
PNG
(2-Oxo-7-phenyl-1,2-dihydrospiro[pyrido[2,3-b][1,4]...)
Show SMILES O=C1Nc2cc(cnc2OC11CCN(C1)C#N)-c1ccccc1
Show InChI InChI=1S/C17H14N4O2/c18-11-21-7-6-17(10-21)16(22)20-14-8-13(9-19-15(14)23-17)12-4-2-1-3-5-12/h1-5,8-9H,6-7,10H2,(H,20,22)
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443277
PNG
(7-(4-Cyanophenyl)-2-oxo- 1,2-dihydrospiro[pyrido [...)
Show SMILES O=C1Nc2cc(cnc2OC11CCN(C1)C#N)-c1ccc(cc1)C#N
Show InChI InChI=1S/C18H13N5O2/c19-8-12-1-3-13(4-2-12)14-7-15-16(21-9-14)25-18(17(24)22-15)5-6-23(10-18)11-20/h1-4,7,9H,5-6,10H2,(H,22,24)
PDB

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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443286
PNG
(US10654853, Example 59)
Show SMILES Fc1ccc(cc1)-c1cnc2NC3(CCN(C3)C#N)C(=O)Nc2c1
Show InChI InChI=1S/C17H14FN5O/c18-13-3-1-11(2-4-13)12-7-14-15(20-8-12)22-17(16(24)21-14)5-6-23(9-17)10-19/h1-4,7-8H,5-6,9H2,(H,20,22)(H,21,24)
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443301
PNG
((S)-7-(4- Fluorophenyl)- 2-oxo-1,2- dihydrospiro [...)
Show SMILES Fc1ccc(cc1)-c1cnc2O[C@]3(CCN(C3)C#N)C(=O)Nc2c1
Show InChI InChI=1S/C17H13FN4O2/c18-13-3-1-11(2-4-13)12-7-14-15(20-8-12)24-17(16(23)21-14)5-6-22(9-17)10-19/h1-4,7-8H,5-6,9H2,(H,21,23)/t17-/m0/s1
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443302
PNG
((S)-7-(3-Cyanophenyl)-2-oxo-1,4-dihydro-2H-spiro[p...)
Show SMILES O=C1Nc2cc(cnc2N[C@]11CCN(C1)C#N)-c1cccc(c1)C#N
Show InChI InChI=1S/C18H14N6O/c19-8-12-2-1-3-13(6-12)14-7-15-16(21-9-14)23-18(17(25)22-15)4-5-24(10-18)11-20/h1-3,6-7,9H,4-5,10H2,(H,21,23)(H,22,25)/t18-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443313
PNG
(2-Oxo-1,2,4,5-tetrahydrospiro[pyrido[2,3-b][1,4]di...)
Show SMILES O=C1Nc2cccnc2NCC11CCN(C1)C#N
Show InChI InChI=1S/C12H13N5O/c13-8-17-5-3-12(7-17)6-15-10-9(16-11(12)18)2-1-4-14-10/h1-2,4H,3,5-7H2,(H,14,15)(H,16,18)
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443320
PNG
(6'-(4-(Benzyloxy)phenyl)-2'-oxo-1',4'- dihydro-2'H...)
Show SMILES O=C1Nc2ccc(cc2CC11CCN(C1)C#N)-c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C26H23N3O2/c27-18-29-13-12-26(17-29)15-22-14-21(8-11-24(22)28-25(26)30)20-6-9-23(10-7-20)31-16-19-4-2-1-3-5-19/h1-11,14H,12-13,15-17H2,(H,28,30)
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443324
PNG
(6'-(1-Methyl-1H-pyrazol-4-yl)-2'-oxo- 1',4'-dihydr...)
Show SMILES Cn1cc(cn1)-c1ccc2NC(=O)C3(CCN(C3)C#N)Cc2c1
Show InChI InChI=1S/C17H17N5O/c1-21-9-14(8-19-21)12-2-3-15-13(6-12)7-17(16(23)20-15)4-5-22(10-17)11-18/h2-3,6,8-9H,4-5,7,10H2,1H3,(H,20,23)
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443330
PNG
(6'-(6-Methoxypyridin-3-yl)-2'-oxo- 1',4'-dihydro-2...)
Show SMILES COc1ccc(cn1)-c1ccc2NC(=O)C3(CCN(C3)C#N)Cc2c1
Show InChI InChI=1S/C19H18N4O2/c1-25-17-5-3-14(10-21-17)13-2-4-16-15(8-13)9-19(18(24)22-16)6-7-23(11-19)12-20/h2-5,8,10H,6-7,9,11H2,1H3,(H,22,24)
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443337
PNG
(4-(1-Cyano-2'-oxo-1',4'-dihydro-2'H- spiro[pyrroli...)
Show SMILES CN(C)C(=O)c1ccc(cc1)-c1ccc2NC(=O)C3(CCN(C3)C#N)Cc2c1
Show InChI InChI=1S/C22H22N4O2/c1-25(2)20(27)16-5-3-15(4-6-16)17-7-8-19-18(11-17)12-22(21(28)24-19)9-10-26(13-22)14-23/h3-8,11H,9-10,12-13H2,1-2H3,(H,24,28)
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443340
PNG
(N-(4-(1-Cyano-2'-oxo-1',4'-dihydro- 2'H-spiro[pyrr...)
Show SMILES CC(=O)Nc1ccc(cc1)-c1ccc2NC(=O)C3(CCN(C3)C#N)Cc2c1
Show InChI InChI=1S/C21H20N4O2/c1-14(26)23-18-5-2-15(3-6-18)16-4-7-19-17(10-16)11-21(20(27)24-19)8-9-25(12-21)13-22/h2-7,10H,8-9,11-12H2,1H3,(H,23,26)(H,24,27)
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443350
PNG
(6'-(2-Methylbenzo[d]thiazol-5-yl)-2'- oxo-1',4'-di...)
Show SMILES Cc1nc2cc(ccc2s1)-c1ccc2NC(=O)C3(CCN(C3)C#N)Cc2c1
Show InChI InChI=1S/C21H18N4OS/c1-13-23-18-9-15(3-5-19(18)27-13)14-2-4-17-16(8-14)10-21(20(26)24-17)6-7-25(11-21)12-22/h2-5,8-9H,6-7,10-11H2,1H3,(H,24,26)
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443354
PNG
(N-Benzyl-4-(1-cyano-2'-oxo-1',4'- dihydro-2'H-spir...)
Show SMILES O=C(NCc1ccccc1)c1ccc(cc1)-c1ccc2NC(=O)C3(CCN(C3)C#N)Cc2c1
Show InChI InChI=1S/C27H24N4O2/c28-18-31-13-12-27(17-31)15-23-14-22(10-11-24(23)30-26(27)33)20-6-8-21(9-7-20)25(32)29-16-19-4-2-1-3-5-19/h1-11,14H,12-13,15-17H2,(H,29,32)(H,30,33)
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443366
PNG
(6-(1H-Indazol-4-yl)-2-oxo-1,2-dihydrospiro[pyrido[...)
Show SMILES O=C1Nc2ccc(nc2OC11CCN(C1)C#N)-c1cccc2[nH]ncc12
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443250
PNG
(7'-(4-(4-Methylpiperazine-1- carbonyl)phenyl)-2'-o...)
Show SMILES O=C(N1CCNCC1)c1ccc(cc1)-c1ccc2CC3(CCN(C3)C#N)C(=O)Nc2c1
Show InChI InChI=1S/C24H25N5O2/c25-16-28-10-7-24(15-28)14-20-6-5-19(13-21(20)27-23(24)31)17-1-3-18(4-2-17)22(30)29-11-8-26-9-12-29/h1-6,13,26H,7-12,14-15H2,(H,27,31)
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443284
PNG
(US10654853, Example 57)
Show SMILES O=C1Nc2cc(cnc2NC11CCN(C1)C#N)-c1ccccc1
Show InChI InChI=1S/C17H15N5O/c18-11-22-7-6-17(10-22)16(23)20-14-8-13(9-19-15(14)21-17)12-4-2-1-3-5-12/h1-5,8-9H,6-7,10H2,(H,19,21)(H,20,23)
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443293
PNG
((S)-2-Oxo-1,4- dihydro-2H- spiro[pyrido[2,3- b]pyr...)
Show SMILES O=C1Nc2cccnc2N[C@]11CCN(C1)C#N
Show InChI InChI=1S/C11H11N5O/c12-7-16-5-3-11(6-16)10(17)14-8-2-1-4-13-9(8)15-11/h1-2,4H,3,5-6H2,(H,13,15)(H,14,17)/t11-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443294
PNG
((R)-2'-Oxo-6'- phenyl-1',4'- dihydro-2'H- spiro[py...)
Show SMILES O=C1Nc2ccc(cc2C[C@]11CCN(C1)C#N)-c1ccccc1
Show InChI InChI=1S/C19H17N3O/c20-13-22-9-8-19(12-22)11-16-10-15(14-4-2-1-3-5-14)6-7-17(16)21-18(19)23/h1-7,10H,8-9,11-12H2,(H,21,23)/t19-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443296
PNG
((S)-7-(3- Fluorophenyl)- 2-oxo-1,2- dihydrospiro [...)
Show SMILES Fc1cccc(c1)-c1cnc2O[C@]3(CCN(C3)C#N)C(=O)Nc2c1
Show InChI InChI=1S/C17H13FN4O2/c18-13-3-1-2-11(6-13)12-7-14-15(20-8-12)24-17(16(23)21-14)4-5-22(9-17)10-19/h1-3,6-8H,4-5,9H2,(H,21,23)/t17-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443328
PNG
(6'-(5-Isopropyl-2-methoxyphenyl)-2'- oxo-1',4'-dih...)
Show SMILES COc1ccc(cc1-c1ccc2NC(=O)C3(CCN(C3)C#N)Cc2c1)C(C)C
Show InChI InChI=1S/C23H25N3O2/c1-15(2)16-5-7-21(28-3)19(11-16)17-4-6-20-18(10-17)12-23(22(27)25-20)8-9-26(13-23)14-24/h4-7,10-11,15H,8-9,12-13H2,1-3H3,(H,25,27)
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443335
PNG
(6'-(5-Methyl-1H-indazol-4-yl)-2'-oxo- 1',4'-dihydr...)
Show SMILES Cc1ccc2[nH]ncc2c1-c1ccc2NC(=O)C3(CCN(C3)C#N)Cc2c1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443339
PNG
(N-(3-(1-Cyano-2'-oxo-1',4'-dihydro- 2'H-spiro[pyrr...)
Show SMILES CC(=O)Nc1cccc(c1)-c1ccc2NC(=O)C3(CCN(C3)C#N)Cc2c1
Show InChI InChI=1S/C21H20N4O2/c1-14(26)23-18-4-2-3-15(10-18)16-5-6-19-17(9-16)11-21(20(27)24-19)7-8-25(12-21)13-22/h2-6,9-10H,7-8,11-12H2,1H3,(H,23,26)(H,24,27)
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443342
PNG
(6'-(1-Methyl-1H-pyrrol-2-yl)-2'-oxo- 1',4'-dihydro...)
Show SMILES Cn1cccc1-c1ccc2NC(=O)C3(CCN(C3)C#N)Cc2c1
Show InChI InChI=1S/C18H18N4O/c1-21-7-2-3-16(21)13-4-5-15-14(9-13)10-18(17(23)20-15)6-8-22(11-18)12-19/h2-5,7,9H,6,8,10-11H2,1H3,(H,20,23)
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443245
PNG
(7'-(3-((2- Chlorobenzyl)oxy)phenyl)-2'- oxo-1',4'-...)
Show SMILES Clc1ccccc1COc1cccc(c1)-c1ccc2CC3(CCN(C3)C#N)C(=O)Nc2c1
Show InChI InChI=1S/C26H22ClN3O2/c27-23-7-2-1-4-21(23)15-32-22-6-3-5-18(12-22)19-8-9-20-14-26(10-11-30(16-26)17-28)25(31)29-24(20)13-19/h1-9,12-13H,10-11,14-16H2,(H,29,31)
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443272
PNG
(6'-(3-Fluorophenyl)- 2'-oxo-1',4'-dihydro- 2'H-spi...)
Show SMILES Fc1cccc(c1)-c1ccc2NC(=O)C3(CCN(C3)C#N)Cc2c1
Show InChI InChI=1S/C19H16FN3O/c20-16-3-1-2-13(9-16)14-4-5-17-15(8-14)10-19(18(24)22-17)6-7-23(11-19)12-21/h1-5,8-9H,6-7,10-11H2,(H,22,24)
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443278
PNG
(7-(3-Cyanophenyl)-2-oxo- 1,2-dihydrospiro[pyrido [...)
Show SMILES O=C1Nc2cc(cnc2OC11CCN(C1)C#N)-c1cccc(c1)C#N
Show InChI InChI=1S/C18H13N5O2/c19-8-12-2-1-3-13(6-12)14-7-15-16(21-9-14)25-18(17(24)22-15)4-5-23(10-18)11-20/h1-3,6-7,9H,4-5,10H2,(H,22,24)
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443291
PNG
((S)-2-Oxo-7-phenyl-1,2-dihydrospiro[pyrido[2,3-b][...)
Show SMILES O=C1Nc2cc(cnc2O[C@]11CCN(C1)C#N)-c1ccccc1
Show InChI InChI=1S/C17H14N4O2/c18-11-21-7-6-17(10-21)16(22)20-14-8-13(9-19-15(14)23-17)12-4-2-1-3-5-12/h1-5,8-9H,6-7,10H2,(H,20,22)/t17-/m0/s1
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443297
PNG
((S)-7-(4- Cyanophenyl)- 2-oxo-1,2- dihydrospiro [p...)
Show SMILES O=C1Nc2cc(cnc2O[C@]11CCN(C1)C#N)-c1ccc(cc1)C#N
Show InChI InChI=1S/C18H13N5O2/c19-8-12-1-3-13(4-2-12)14-7-15-16(21-9-14)25-18(17(24)22-15)5-6-23(10-18)11-20/h1-4,7,9H,5-6,10H2,(H,22,24)/t18-/m0/s1
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443343
PNG
(6'-(4-(Morpholinosulfonyl)phenyl)-2'- oxo-1',4'-di...)
Show SMILES O=C1Nc2ccc(cc2CC11CCN(C1)C#N)-c1ccc(cc1)S(=O)(=O)N1CCOCC1
Show InChI InChI=1S/C23H24N4O4S/c24-16-26-8-7-23(15-26)14-19-13-18(3-6-21(19)25-22(23)28)17-1-4-20(5-2-17)32(29,30)27-9-11-31-12-10-27/h1-6,13H,7-12,14-15H2,(H,25,28)
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443344
PNG
(6'-(3,5-Dimethyl-1H-pyrazol-4-yl)-2'- oxo-1',4'-di...)
Show SMILES Cc1n[nH]c(C)c1-c1ccc2NC(=O)C3(CCN(C3)C#N)Cc2c1
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443347
PNG
(6'-(4-(Morpholine-4-carbonyl)phenyl)- 2'-oxo-1',4'...)
Show SMILES O=C(N1CCOCC1)c1ccc(cc1)-c1ccc2NC(=O)C3(CCN(C3)C#N)Cc2c1
Show InChI InChI=1S/C24H24N4O3/c25-16-27-8-7-24(15-27)14-20-13-19(5-6-21(20)26-23(24)30)17-1-3-18(4-2-17)22(29)28-9-11-31-12-10-28/h1-6,13H,7-12,14-15H2,(H,26,30)
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443373
PNG
(7-(1,4-Dimethyl-1H- pyrazol-5-yl)-2-oxo- 1,4-dihyd...)
Show SMILES Cc1cnn(C)c1-c1cnc2NC3(CCN(C3)C#N)C(=O)Nc2c1
Show InChI InChI=1S/C16H17N7O/c1-10-6-19-22(2)13(10)11-5-12-14(18-7-11)21-16(15(24)20-12)3-4-23(8-16)9-17/h5-7H,3-4,8H2,1-2H3,(H,18,21)(H,20,24)
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443243
PNG
(7'-(2-(Benzyloxy)phenyl)-2'- oxo-1',4'-dihydro-2'H...)
Show SMILES O=C1Nc2cc(ccc2CC11CCN(C1)C#N)-c1ccccc1OCc1ccccc1
Show InChI InChI=1S/C26H23N3O2/c27-18-29-13-12-26(17-29)15-21-11-10-20(14-23(21)28-25(26)30)22-8-4-5-9-24(22)31-16-19-6-2-1-3-7-19/h1-11,14H,12-13,15-17H2,(H,28,30)
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443248
PNG
(7'-(5-Fluoro-2- isopropoxyphenyl)-2'-oxo- 1',4'-di...)
Show SMILES CC(C)Oc1ccc(F)cc1-c1ccc2CC3(CCN(C3)C#N)C(=O)Nc2c1
Show InChI InChI=1S/C22H22FN3O2/c1-14(2)28-20-6-5-17(23)10-18(20)15-3-4-16-11-22(7-8-26(12-22)13-24)21(27)25-19(16)9-15/h3-6,9-10,14H,7-8,11-12H2,1-2H3,(H,25,27)
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443249
PNG
(7'-(3-Methyl-1H-indazol-6-yl)- 2'-oxo-1',4'-dihydr...)
Show SMILES Cc1n[nH]c2cc(ccc12)-c1ccc2CC3(CCN(C3)C#N)C(=O)Nc2c1
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443252
PNG
(7'-(5-Methyl-1H-indazol-4-yl)- 2'-oxo-1',4'-dihydr...)
Show SMILES Cc1ccc2[nH]ncc2c1-c1ccc2CC3(CCN(C3)C#N)C(=O)Nc2c1
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443269
PNG
(6'-(4-Cyanophenyl)- 2'-oxo-1',4'-dihydro- 2'H-spir...)
Show SMILES O=C1Nc2ccc(cc2CC11CCN(C1)C#N)-c1ccc(cc1)C#N
Show InChI InChI=1S/C20H16N4O/c21-11-14-1-3-15(4-2-14)16-5-6-18-17(9-16)10-20(19(25)23-18)7-8-24(12-20)13-22/h1-6,9H,7-8,10,12H2,(H,23,25)
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443279
PNG
(7-(4-Fluorophenyl)-2-oxo- 1,2-dihydrospiro[pyrido ...)
Show SMILES Fc1ccc(cc1)-c1cnc2OC3(CCN(C3)C#N)C(=O)Nc2c1
Show InChI InChI=1S/C17H13FN4O2/c18-13-3-1-11(2-4-13)12-7-14-15(20-8-12)24-17(16(23)21-14)5-6-22(9-17)10-19/h1-4,7-8H,5-6,9H2,(H,21,23)
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443280
PNG
(7-(3-Fluorophenyl)-2-oxo- 1,2-dihydrospiro[pyrido ...)
Show SMILES Fc1cccc(c1)-c1cnc2OC3(CCN(C3)C#N)C(=O)Nc2c1
Show InChI InChI=1S/C17H13FN4O2/c18-13-3-1-2-11(6-13)12-7-14-15(20-8-12)24-17(16(23)21-14)4-5-22(9-17)10-19/h1-3,6-8H,4-5,9H2,(H,21,23)
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443295
PNG
((S)-2-Oxo-7- phenyl- 1,4-dihydro-2H- spiro[pyrido[...)
Show SMILES O=C1Nc2cc(cnc2N[C@]11CCN(C1)C#N)-c1ccccc1
Show InChI InChI=1S/C17H15N5O/c18-11-22-7-6-17(10-22)16(23)20-14-8-13(9-19-15(14)21-17)12-4-2-1-3-5-12/h1-5,8-9H,6-7,10H2,(H,19,21)(H,20,23)/t17-/m0/s1
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443332
PNG
(6'-(3-Methyl-1H-indazol-6-yl)-2'-oxo- 1',4'-dihydr...)
Show SMILES O=C1Nc2ccc(cc2CC11CCN(C1)C#N)-c1ccc2cn[nH]c2c1
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443345
PNG
(2'-Oxo-6'-(3-(piperidin-1-yl)phenyl)- 1',4'-dihydr...)
Show SMILES O=C1Nc2ccc(cc2CC11CCN(C1)C#N)-c1cccc(c1)N1CCCCC1
Show InChI InChI=1S/C24H26N4O/c25-17-27-12-9-24(16-27)15-20-13-19(7-8-22(20)26-23(24)29)18-5-4-6-21(14-18)28-10-2-1-3-11-28/h4-8,13-14H,1-3,9-12,15-16H2,(H,26,29)
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443351
PNG
(6'-(3,5-Dimethylisoxazol-4-yl)-2'-oxo- 1',4'-dihyd...)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C3(CCN(C3)C#N)Cc2c1
Show InChI InChI=1S/C18H18N4O2/c1-11-16(12(2)24-21-11)13-3-4-15-14(7-13)8-18(17(23)20-15)5-6-22(9-18)10-19/h3-4,7H,5-6,8-9H2,1-2H3,(H,20,23)
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443270
PNG
(6'-(3-Cyanophenyl)- 2'-oxo-1',4'-dihydro- 2'H-spir...)
Show SMILES O=C1Nc2ccc(cc2CC11CCN(C1)C#N)-c1cccc(c1)C#N
Show InChI InChI=1S/C20H16N4O/c21-11-14-2-1-3-15(8-14)16-4-5-18-17(9-16)10-20(19(25)23-18)6-7-24(12-20)13-22/h1-5,8-9H,6-7,10,12H2,(H,23,25)
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443275
PNG
(US10654853, Example 48)
Show SMILES O=C1Nc2cccnc2OC11CCN(C1)C#N
Show InChI InChI=1S/C11H10N4O2/c12-7-15-5-3-11(6-15)10(16)14-8-2-1-4-13-9(8)17-11/h1-2,4H,3,5-6H2,(H,14,16)
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443298
PNG
((S)-7-(3- Cyanophenyl)- 2-oxo-1,2- dihydrospiro [p...)
Show SMILES O=C1Nc2cc(cnc2O[C@]11CCN(C1)C#N)-c1cccc(c1)C#N
Show InChI InChI=1S/C18H13N5O2/c19-8-12-2-1-3-13(6-12)14-7-15-16(21-9-14)25-18(17(24)22-15)4-5-23(10-18)11-20/h1-3,6-7,9H,4-5,10H2,(H,22,24)/t18-/m0/s1
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443317
PNG
(7'-(3-(4-Methylpiperazine-1- carbonyl)phenyl)-2'-o...)
Show SMILES CN1CCN(CC1)C(=O)c1cccc(c1)-c1ccc2CC3(CCN(C3)C#N)C(=O)Nc2c1
Show InChI InChI=1S/C25H27N5O2/c1-28-9-11-30(12-10-28)23(31)20-4-2-3-18(13-20)19-5-6-21-15-25(7-8-29(16-25)17-26)24(32)27-22(21)14-19/h2-6,13-14H,7-12,15-16H2,1H3,(H,27,32)
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443322
PNG
(2'-Oxo-6'-(3- (trifluoromethoxy)phenyl)-1',4'- dih...)
Show SMILES FC(F)(F)Oc1cccc(c1)-c1ccc2NC(=O)C3(CCN(C3)C#N)Cc2c1
Show InChI InChI=1S/C20H16F3N3O2/c21-20(22,23)28-16-3-1-2-13(9-16)14-4-5-17-15(8-14)10-19(18(27)25-17)6-7-26(11-19)12-24/h1-5,8-9H,6-7,10-11H2,(H,25,27)
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443325
PNG
(5-(1-Cyano-2'-oxo-1',4'-dihydro-2'H- spiro[pyrroli...)
Show SMILES CNC(=O)c1ccc(cn1)-c1ccc2NC(=O)C3(CCN(C3)C#N)Cc2c1
Show InChI InChI=1S/C20H19N5O2/c1-22-18(26)17-5-3-14(10-23-17)13-2-4-16-15(8-13)9-20(19(27)24-16)6-7-25(11-20)12-21/h2-5,8,10H,6-7,9,11H2,1H3,(H,22,26)(H,24,27)
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443334
PNG
(6'-(1-Methyl-1H-indazol-5-yl)-2'-oxo- 1',4'-dihydr...)
Show SMILES Cn1ncc2cc(ccc12)-c1ccc2NC(=O)C3(CCN(C3)C#N)Cc2c1
Show InChI InChI=1S/C21H19N5O/c1-25-19-5-3-15(9-17(19)11-23-25)14-2-4-18-16(8-14)10-21(20(27)24-18)6-7-26(12-21)13-22/h2-5,8-9,11H,6-7,10,12H2,1H3,(H,24,27)
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443336
PNG
(N-(3-(1-Cyano-2'-oxo-1',4'-dihydro- 2'H-spiro[pyrr...)
Show SMILES O=C1Nc2ccc(cc2CC11CCN(C1)C#N)-c1cccc(NS(=O)(=O)C2CC2)c1
Show InChI InChI=1S/C22H22N4O3S/c23-14-26-9-8-22(13-26)12-17-10-16(4-7-20(17)24-21(22)27)15-2-1-3-18(11-15)25-30(28,29)19-5-6-19/h1-4,7,10-11,19,25H,5-6,8-9,12-13H2,(H,24,27)
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443338
PNG
(2'-Oxo-6'-(pyrimidin-5-yl)-1',4'- dihydro-2'H-spir...)
Show SMILES O=C1Nc2ccc(cc2CC11CCN(C1)C#N)-c1cncnc1
Show InChI InChI=1S/C17H15N5O/c18-10-22-4-3-17(9-22)6-13-5-12(14-7-19-11-20-8-14)1-2-15(13)21-16(17)23/h1-2,5,7-8,11H,3-4,6,9H2,(H,21,23)
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443341
PNG
(6'-(3-(4-Methylpiperazine-1- carbonyl)phenyl)-2'-o...)
Show SMILES O=C(N1CCNCC1)c1cccc(c1)-c1ccc2NC(=O)C3(CCN(C3)C#N)Cc2c1
Show InChI InChI=1S/C24H25N5O2/c25-16-28-9-6-24(15-28)14-20-13-18(4-5-21(20)27-23(24)31)17-2-1-3-19(12-17)22(30)29-10-7-26-8-11-29/h1-5,12-13,26H,6-11,14-15H2,(H,27,31)
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443355
PNG
(6'-(3-Methyl-1H-pyrazol-4-yl)-2'-oxo- 1',4'-dihydr...)
Show SMILES Cc1n[nH]cc1-c1ccc2NC(=O)C3(CCN(C3)C#N)Cc2c1
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443357
PNG
(3-(1-Cyano-2'-oxo-1',4'-dihydro-2'H- spiro[pyrroli...)
Show SMILES CN(C)C(=O)c1cccc(c1)-c1ccc(cc1)-c1ccc2NC(=O)C3(CCN(C3)C#N)Cc2c1
Show InChI InChI=1S/C28H26N4O2/c1-31(2)26(33)23-5-3-4-21(14-23)19-6-8-20(9-7-19)22-10-11-25-24(15-22)16-28(27(34)30-25)12-13-32(17-28)18-29/h3-11,14-15H,12-13,16-17H2,1-2H3,(H,30,34)
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443359
PNG
((R)-7′-(5-Methyl-H-indazol-4-yl)-2′-ox...)
Show SMILES Cc1ccc2[nH]ncc2c1-c1ccc2C[C@]3(CCN(C3)C#N)C(=O)Nc2c1
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443360
PNG
(7′-(1H-Indazol-4-yl)-2′-oxo-1′,4...)
Show SMILES O=C1Nc2cc(ccc2CC11CCN(C1)C#N)-c1cccc2[nH]ncc12
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443371
PNG
(1′-Cyano-N-(2-fluorophenyl)-2-oxo-1,2-dihydr...)
Show SMILES Fc1ccccc1NC(=O)c1ccc2NC(=O)C3(CCN(C3)C#N)Oc2n1
Show InChI InChI=1S/C18H14FN5O3/c19-11-3-1-2-4-12(11)21-15(25)13-5-6-14-16(22-13)27-18(17(26)23-14)7-8-24(9-18)10-20/h1-6H,7-9H2,(H,21,25)(H,23,26)
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443253
PNG
(N-(3-(1-Cyano-2'-oxo-1',4'- dihydro-2'H- spiro[pyr...)
Show SMILES O=C1Nc2cc(ccc2CC11CCN(C1)C#N)-c1cccc(NS(=O)(=O)C2CC2)c1
Show InChI InChI=1S/C22H22N4O3S/c23-14-26-9-8-22(13-26)12-17-5-4-16(11-20(17)24-21(22)27)15-2-1-3-18(10-15)25-30(28,29)19-6-7-19/h1-5,10-11,19,25H,6-9,12-13H2,(H,24,27)
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443267
PNG
(7'-(2-Methylbenzo[d]thiazol- 5-yl)-2'-oxo-1',4'-di...)
Show SMILES Cc1nc2cc(ccc2s1)-c1ccc2CC3(CCN(C3)C#N)C(=O)Nc2c1
Show InChI InChI=1S/C21H18N4OS/c1-13-23-18-9-15(4-5-19(18)27-13)14-2-3-16-10-21(6-7-25(11-21)12-22)20(26)24-17(16)8-14/h2-5,8-9H,6-7,10-11H2,1H3,(H,24,26)
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443281
PNG
(2-Oxo-6-phenyl-1,2-dihydrospiro[pyrido[2,3-b][1,4]...)
Show SMILES O=C1Nc2ccc(nc2OC11CCN(C1)C#N)-c1ccccc1
Show InChI InChI=1S/C17H14N4O2/c18-11-21-9-8-17(10-21)16(22)20-14-7-6-13(19-15(14)23-17)12-4-2-1-3-5-12/h1-7H,8-10H2,(H,20,22)
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443285
PNG
(7-(4-Cyanophenyl)-2- oxo-1,4-dihydro-2H- spiro[pyr...)
Show SMILES O=C1Nc2cc(cnc2NC11CCN(C1)C#N)-c1ccc(cc1)C#N
Show InChI InChI=1S/C18H14N6O/c19-8-12-1-3-13(4-2-12)14-7-15-16(21-9-14)23-18(17(25)22-15)5-6-24(10-18)11-20/h1-4,7,9H,5-6,10H2,(H,21,23)(H,22,25)
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443327
PNG
(4-(1-Cyano-2'-oxo-1',4'-dihydro-2'H- spiro[pyrroli...)
Show SMILES CNC(=O)c1ccc(cc1)-c1ccc2NC(=O)C3(CCN(C3)C#N)Cc2c1
Show InChI InChI=1S/C21H20N4O2/c1-23-19(26)15-4-2-14(3-5-15)16-6-7-18-17(10-16)11-21(20(27)24-18)8-9-25(12-21)13-22/h2-7,10H,8-9,11-12H2,1H3,(H,23,26)(H,24,27)
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443331
PNG
(6'-(5-Fluoro-2-isopropoxyphenyl)-2'- oxo-1',4'-dih...)
Show SMILES CC(C)Oc1ccc(F)cc1-c1ccc2NC(=O)C3(CCN(C3)C#N)Cc2c1
Show InChI InChI=1S/C22H22FN3O2/c1-14(2)28-20-6-4-17(23)10-18(20)15-3-5-19-16(9-15)11-22(21(27)25-19)7-8-26(12-22)13-24/h3-6,9-10,14H,7-8,11-12H2,1-2H3,(H,25,27)
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443352
PNG
(6'-(2-Chloro-5- (trifluoromethoxy)phenyl)-2'-oxo-1...)
Show SMILES FC(F)(F)Oc1ccc(Cl)c(c1)-c1ccc2NC(=O)C3(CCN(C3)C#N)Cc2c1
Show InChI InChI=1S/C20H15ClF3N3O2/c21-16-3-2-14(29-20(22,23)24)8-15(16)12-1-4-17-13(7-12)9-19(18(28)26-17)5-6-27(10-19)11-25/h1-4,7-8H,5-6,9-10H2,(H,26,28)
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443358
PNG
(6'-(2-Methylpyridin-4-yl)-2'-oxo-1',4'- dihydro-2'...)
Show SMILES O=C1Nc2ccc(cc2CC11CCN(C1)C#N)-c1ccncc1
Show InChI InChI=1S/C18H16N4O/c19-12-22-8-5-18(11-22)10-15-9-14(13-3-6-20-7-4-13)1-2-16(15)21-17(18)23/h1-4,6-7,9H,5,8,10-11H2,(H,21,23)
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443361
PNG
(6′-(1H-Indazol-4-yl)-2′-oxo-1′,4...)
Show SMILES O=C1Nc2ccc(cc2CC11CCN(C1)C#N)-c1cccc2[nH]ncc12
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443257
PNG
(3-(1-Cyano-2'-oxo-1',4'- dihydro-2'H- spiro[pyrrol...)
Show SMILES CN(C)C(=O)c1cccc(c1)-c1ccc2CC3(CCN(C3)C#N)C(=O)Nc2c1
Show InChI InChI=1S/C22H22N4O2/c1-25(2)20(27)17-5-3-4-15(10-17)16-6-7-18-12-22(8-9-26(13-22)14-23)21(28)24-19(18)11-16/h3-7,10-11H,8-9,12-13H2,1-2H3,(H,24,28)
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443263
PNG
(N-(2-(1-Cyano-2'-oxo-1',4'- dihydro-2'H- spiro[pyr...)
Show SMILES CC(=O)Nc1ccccc1-c1ccc2CC3(CCN(C3)C#N)C(=O)Nc2c1
Show InChI InChI=1S/C21H20N4O2/c1-14(26)23-18-5-3-2-4-17(18)15-6-7-16-11-21(8-9-25(12-21)13-22)20(27)24-19(16)10-15/h2-7,10H,8-9,11-12H2,1H3,(H,23,26)(H,24,27)
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n/an/a 550n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443316
PNG
(4-(1-Cyano-2'-oxo-1',4'- dihydro-2'H- spiro[pyrrol...)
Show SMILES CN(C)C(=O)c1ccc(cc1)-c1ccc2CC3(CCN(C3)C#N)C(=O)Nc2c1
Show InChI InChI=1S/C22H22N4O2/c1-25(2)20(27)16-5-3-15(4-6-16)17-7-8-18-12-22(9-10-26(13-22)14-23)21(28)24-19(18)11-17/h3-8,11H,9-10,12-13H2,1-2H3,(H,24,28)
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n/an/a 5.50E+3n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443244
PNG
(4-(1-Cyano-2'-oxo-1',4'- dihydro-2'H- spiro[pyrrol...)
Show SMILES CNC(=O)c1ccc(cc1)-c1ccc2CC3(CCN(C3)C#N)C(=O)Nc2c1
Show InChI InChI=1S/C21H20N4O2/c1-23-19(26)15-4-2-14(3-5-15)16-6-7-17-11-21(8-9-25(12-21)13-22)20(27)24-18(17)10-16/h2-7,10H,8-9,11-12H2,1H3,(H,23,26)(H,24,27)
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n/an/a 5.50E+3n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443247
PNG
(7'-(6-Methoxypyridin-3-yl)-2'- oxo-1',4'-dihydro-2...)
Show SMILES COc1ccc(cn1)-c1ccc2CC3(CCN(C3)C#N)C(=O)Nc2c1
Show InChI InChI=1S/C19H18N4O2/c1-25-17-5-4-15(10-21-17)13-2-3-14-9-19(6-7-23(11-19)12-20)18(24)22-16(14)8-13/h2-5,8,10H,6-7,9,11H2,1H3,(H,22,24)
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n/an/a 5.50E+3n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443266
PNG
(7'-(1-Methyl-6-oxo-1,6- dihydropyridin-3-yl)-2'-ox...)
Show SMILES Cn1cc(ccc1=O)-c1ccc2CC3(CCN(C3)C#N)C(=O)Nc2c1
Show InChI InChI=1S/C19H18N4O2/c1-22-10-15(4-5-17(22)24)13-2-3-14-9-19(6-7-23(11-19)12-20)18(25)21-16(14)8-13/h2-5,8,10H,6-7,9,11H2,1H3,(H,21,25)
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n/an/a 5.50E+3n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443273
PNG
(1-Cyano-N,N-dimethyl-2′-oxo-1′,4′...)
Show SMILES CN(C)C(=O)c1ccc2CC3(CCN(C3)C#N)C(=O)Nc2c1
Show InChI InChI=1S/C16H18N4O2/c1-19(2)14(21)11-3-4-12-8-16(5-6-20(9-16)10-17)15(22)18-13(12)7-11/h3-4,7H,5-6,8-9H2,1-2H3,(H,18,22)
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n/an/a 5.50E+3n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443274
PNG
(1-Cyano-N-methyl-2′-oxo-1′,4′-di...)
Show SMILES CNC(=O)c1ccc2CC3(CCN(C3)C#N)C(=O)Nc2c1
Show InChI InChI=1S/C15H16N4O2/c1-17-13(20)10-2-3-11-7-15(4-5-19(8-15)9-16)14(21)18-12(11)6-10/h2-3,6H,4-5,7-8H2,1H3,(H,17,20)(H,18,21)
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n/an/a 5.50E+3n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443306
PNG
(7,10-Dioxo-8-phenyl-2,6,9-triazaspiro[4.5]decane-2...)
Show SMILES O=C1NC2(CCN(C2)C#N)C(=O)NC1c1ccccc1
Show InChI InChI=1S/C14H14N4O2/c15-9-18-7-6-14(8-18)13(20)16-11(12(19)17-14)10-4-2-1-3-5-10/h1-5,11H,6-8H2,(H,16,20)(H,17,19)
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n/an/a 5.50E+3n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443349
PNG
(6'-(1-Methyl-6-oxo-1,6-dihydropyridin- 3-yl)-2'-ox...)
Show SMILES Cn1cc(ccc1=O)-c1ccc2NC(=O)C3(CCN(C3)C#N)Cc2c1
Show InChI InChI=1S/C19H18N4O2/c1-22-10-14(3-5-17(22)24)13-2-4-16-15(8-13)9-19(18(25)21-16)6-7-23(11-19)12-20/h2-5,8,10H,6-7,9,11H2,1H3,(H,21,25)
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n/an/a 5.50E+3n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443369
PNG
(2-Oxo-6-(piperidine-1-carbonyl)-1,2-dihydrospiro[p...)
Show SMILES O=C(N1CCCCC1)c1ccc2NC(=O)C3(CCN(C3)C#N)Oc2n1
Show InChI InChI=1S/C17H19N5O3/c18-11-21-9-6-17(10-21)16(24)20-12-4-5-13(19-14(12)25-17)15(23)22-7-2-1-3-8-22/h4-5H,1-3,6-10H2,(H,20,24)
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MISSION THERAPEUTICS LIMITED

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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443232
PNG
(US10654853, Example 5)
Show SMILES COc1ccc(cc1-c1ccc2CC3(CCN(C3)C#N)C(=O)Nc2c1)C(C)C
Show InChI InChI=1S/C23H25N3O2/c1-15(2)16-6-7-21(28-3)19(10-16)17-4-5-18-12-23(8-9-26(13-23)14-24)22(27)25-20(18)11-17/h4-7,10-11,15H,8-9,12-13H2,1-3H3,(H,25,27)
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443241
PNG
(7'-(2-Chloro-5- (trifluoromethoxy)phenyl)-2'- oxo-...)
Show SMILES FC(F)(F)Oc1ccc(Cl)c(c1)-c1ccc2CC3(CCN(C3)C#N)C(=O)Nc2c1
Show InChI InChI=1S/C20H15ClF3N3O2/c21-16-4-3-14(29-20(22,23)24)8-15(16)12-1-2-13-9-19(5-6-27(10-19)11-25)18(28)26-17(13)7-12/h1-4,7-8H,5-6,9-10H2,(H,26,28)
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MISSION THERAPEUTICS LIMITED

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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443254
PNG
(7'-(3-Methyl-1H-pyrazol-4- yl)-2'-oxo-1',4'-dihydr...)
Show SMILES Cc1n[nH]cc1-c1ccc2CC3(CCN(C3)C#N)C(=O)Nc2c1
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443256
PNG
(N-(3-(1-Cyano-2'-oxo-1',4'- dihydro-2'H- spiro[pyr...)
Show SMILES CC(=O)Nc1cccc(c1)-c1ccc2CC3(CCN(C3)C#N)C(=O)Nc2c1
Show InChI InChI=1S/C21H20N4O2/c1-14(26)23-18-4-2-3-15(9-18)16-5-6-17-11-21(7-8-25(12-21)13-22)20(27)24-19(17)10-16/h2-6,9-10H,7-8,11-12H2,1H3,(H,23,26)(H,24,27)
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443262
PNG
(2'-Oxo-7'-(3-(piperidin-1- yl)phenyl)-1',4'-dihydr...)
Show SMILES O=C1Nc2cc(ccc2CC11CCN(C1)C#N)-c1cccc(c1)N1CCCCC1
Show InChI InChI=1S/C24H26N4O/c25-17-27-12-9-24(16-27)15-20-8-7-19(14-22(20)26-23(24)29)18-5-4-6-21(13-18)28-10-2-1-3-11-28/h4-8,13-14H,1-3,9-12,15-16H2,(H,26,29)
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443283
PNG
(2-Oxo-6-(trifluoromethyl)-1,4-dihydro-2H-spiro[pyr...)
Show SMILES FC(F)(F)c1ccc2NC(=O)C3(CCN(C3)C#N)Nc2n1
Show InChI InChI=1S/C12H10F3N5O/c13-12(14,15)8-2-1-7-9(18-8)19-11(10(21)17-7)3-4-20(5-11)6-16/h1-2H,3-5H2,(H,17,21)(H,18,19)
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443304
PNG
(7,10-Dioxo-2,6,9-triazaspiro[4.5]decane-2-carbonit...)
Show SMILES O=C1CNC(=O)C2(CCN(C2)C#N)N1
Show InChI InChI=1S/C8H10N4O2/c9-5-12-2-1-8(4-12)7(14)10-3-6(13)11-8/h1-4H2,(H,10,14)(H,11,13)
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443305
PNG
((8S)-8-Methyl-7,10-dioxo-2,6,9-triazaspiro[4.5]dec...)
Show SMILES C[C@@H]1NC(=O)C2(CCN(C2)C#N)NC1=O
Show InChI InChI=1S/C9H12N4O2/c1-6-7(14)12-9(8(15)11-6)2-3-13(4-9)5-10/h6H,2-4H2,1H3,(H,11,15)(H,12,14)/t6-,9?/m0/s1
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443230
PNG
(US10654853, Example 3)
Show SMILES COc1ccc2CC3(CCN(C3)C#N)C(=O)Nc2c1
Show InChI InChI=1S/C14H15N3O2/c1-19-11-3-2-10-7-14(4-5-17(8-14)9-15)13(18)16-12(10)6-11/h2-3,6H,4-5,7-8H2,1H3,(H,16,18)
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443239
PNG
(7'-(1-Methyl-1H-pyrazol-4- yl)-2'-oxo-1',4'-dihydr...)
Show SMILES Cn1cc(cn1)-c1ccc2CC3(CCN(C3)C#N)C(=O)Nc2c1
Show InChI InChI=1S/C17H17N5O/c1-21-9-14(8-19-21)12-2-3-13-7-17(4-5-22(10-17)11-18)16(23)20-15(13)6-12/h2-3,6,8-9H,4-5,7,10H2,1H3,(H,20,23)
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443235
PNG
(7'-(2-Fluoro-5-methylphenyl)- 2'-oxo-1',4'-dihydro...)
Show SMILES Cc1ccc(F)c(c1)-c1ccc2CC3(CCN(C3)C#N)C(=O)Nc2c1
Show InChI InChI=1S/C20H18FN3O/c1-13-2-5-17(21)16(8-13)14-3-4-15-10-20(6-7-24(11-20)12-22)19(25)23-18(15)9-14/h2-5,8-9H,6-7,10-11H2,1H3,(H,23,25)
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443368
PNG
(1′-Cyano-N-(4-fluorophenyl)-2-oxo-1,2-dihydr...)
Show SMILES Fc1ccc(NC(=O)c2ccc3NC(=O)C4(CCN(C4)C#N)Oc3n2)cc1
Show InChI InChI=1S/C18H14FN5O3/c19-11-1-3-12(4-2-11)21-15(25)13-5-6-14-16(22-13)27-18(17(26)23-14)7-8-24(9-18)10-20/h1-6H,7-9H2,(H,21,25)(H,23,26)
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MISSION THERAPEUTICS LIMITED

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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443333
PNG
(6'-(4-(4-Methylpiperazine-1- carbonyl)phenyl)-2'-o...)
Show SMILES CN1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2NC(=O)C3(CCN(C3)C#N)Cc2c1
Show InChI InChI=1S/C25H27N5O2/c1-28-10-12-30(13-11-28)23(31)19-4-2-18(3-5-19)20-6-7-22-21(14-20)15-25(24(32)27-22)8-9-29(16-25)17-26/h2-7,14H,8-13,15-16H2,1H3,(H,27,32)
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443229
PNG
(US10654853, Example 2)
Show SMILES Clc1ccc2CC3(CCN(C3)C#N)C(=O)Nc2c1
Show InChI InChI=1S/C13H12ClN3O/c14-10-2-1-9-6-13(3-4-17(7-13)8-15)12(18)16-11(9)5-10/h1-2,5H,3-4,6-7H2,(H,16,18)
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443288
PNG
(3-Oxo-3,4-dihydro-1H-spiro[pyrido[2,3-b]pyrazine-2...)
Show SMILES O=C1Nc2ncccc2NC11CCN(C1)C#N
Show InChI InChI=1S/C11H11N5O/c12-7-16-5-3-11(6-16)10(17)14-9-8(15-11)2-1-4-13-9/h1-2,4,15H,3,5-6H2,(H,13,14,17)
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443292
PNG
((S)-2-Oxo-1,2- dihydrospiro [pyrido[2,3- b][1,4]ox...)
Show SMILES O=C1Nc2cccnc2O[C@]11CCN(C1)C#N
Show InChI InChI=1S/C11H10N4O2/c12-7-15-5-3-11(6-15)10(16)14-8-2-1-4-13-9(8)17-11/h1-2,4H,3,5-6H2,(H,14,16)/t11-/m0/s1
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443323
PNG
(2'-Oxo-6'-(4-phenoxyphenyl)-1',4'- dihydro-2'H-spi...)
Show SMILES O=C1Nc2ccc(cc2CC11CCN(C1)C#N)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C25H21N3O2/c26-17-28-13-12-25(16-28)15-20-14-19(8-11-23(20)27-24(25)29)18-6-9-22(10-7-18)30-21-4-2-1-3-5-21/h1-11,14H,12-13,15-16H2,(H,27,29)
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443329
PNG
(6'-(3-((2-Chlorobenzyl)oxy)phenyl)-2'- oxo-1',4'-d...)
Show SMILES Clc1ccccc1COc1cccc(c1)-c1ccc2NC(=O)C3(CCN(C3)C#N)Cc2c1
Show InChI InChI=1S/C26H22ClN3O2/c27-23-7-2-1-4-20(23)15-32-22-6-3-5-18(13-22)19-8-9-24-21(12-19)14-26(25(31)29-24)10-11-30(16-26)17-28/h1-9,12-13H,10-11,14-16H2,(H,29,31)
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443374
PNG
(2-Oxo-6-phenyl-1,4-dihydro-2H-spiro[pyrido[2,3-b]p...)
Show SMILES O=C1Nc2ccc(nc2NC11CCN(C1)C#N)-c1ccccc1
Show InChI InChI=1S/C17H15N5O/c18-11-22-9-8-17(10-22)16(23)20-14-7-6-13(19-15(14)21-17)12-4-2-1-3-5-12/h1-7H,8-10H2,(H,19,21)(H,20,23)
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443238
PNG
(2'-Oxo-7'-(4-phenoxyphenyl)- 1',4'-dihydro-2'H- sp...)
Show SMILES O=C1Nc2cc(ccc2CC11CCN(C1)C#N)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C25H21N3O2/c26-17-28-13-12-25(16-28)15-20-7-6-19(14-23(20)27-24(25)29)18-8-10-22(11-9-18)30-21-4-2-1-3-5-21/h1-11,14H,12-13,15-16H2,(H,27,29)
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443242
PNG
(5-(1-Cyano-2'-oxo-1',4'- dihydro-2'H- spiro[pyrrol...)
Show SMILES CNC(=O)c1ccc(cn1)-c1ccc2CC3(CCN(C3)C#N)C(=O)Nc2c1
Show InChI InChI=1S/C20H19N5O2/c1-22-18(26)16-5-4-15(10-23-16)13-2-3-14-9-20(6-7-25(11-20)12-21)19(27)24-17(14)8-13/h2-5,8,10H,6-7,9,11H2,1H3,(H,22,26)(H,24,27)
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443258
PNG
(N-(4-(1-Cyano-2'-oxo-1',4'- dihydro-2'H- spiro[pyr...)
Show SMILES CC(=O)Nc1ccc(cc1)-c1ccc2CC3(CCN(C3)C#N)C(=O)Nc2c1
Show InChI InChI=1S/C21H20N4O2/c1-14(26)23-18-6-4-15(5-7-18)16-2-3-17-11-21(8-9-25(12-21)13-22)20(27)24-19(17)10-16/h2-7,10H,8-9,11-12H2,1H3,(H,23,26)(H,24,27)
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MISSION THERAPEUTICS LIMITED

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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443265
PNG
(7'-(3- (Morpholinosulfonyl)phenyl)- 2'-oxo-1',4'-d...)
Show SMILES O=C1Nc2cc(ccc2CC11CCN(C1)C#N)-c1cccc(c1)S(=O)(=O)N1CCOCC1
Show InChI InChI=1S/C23H24N4O4S/c24-16-26-7-6-23(15-26)14-19-5-4-18(13-21(19)25-22(23)28)17-2-1-3-20(12-17)32(29,30)27-8-10-31-11-9-27/h1-5,12-13H,6-11,14-15H2,(H,25,28)
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MISSION THERAPEUTICS LIMITED

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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443326
PNG
(6'-(2-(Benzyloxy)phenyl)-2'-oxo-1',4'- dihydro-2'H...)
Show SMILES O=C1Nc2ccc(cc2CC11CCN(C1)C#N)-c1ccccc1Oc1ccccc1
Show InChI InChI=1S/C25H21N3O2/c26-17-28-13-12-25(16-28)15-19-14-18(10-11-22(19)27-24(25)29)21-8-4-5-9-23(21)30-20-6-2-1-3-7-20/h1-11,14H,12-13,15-16H2,(H,27,29)
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n/an/a 5.50E+3n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443231
PNG
(US10654853, Example 4)
Show SMILES O=C1Nc2cc(ccc2CC11CCN(C1)C#N)-c1ccccc1
Show InChI InChI=1S/C19H17N3O/c20-13-22-9-8-19(12-22)11-16-7-6-15(10-17(16)21-18(19)23)14-4-2-1-3-5-14/h1-7,10H,8-9,11-12H2,(H,21,23)
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443234
PNG
(7'-(4-(Benzyloxy)phenyl)-2'- oxo-1',4'-dihydro-2'H...)
Show SMILES O=C1Nc2cc(ccc2CC11CCN(C1)C#N)-c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C26H23N3O2/c27-18-29-13-12-26(17-29)15-22-7-6-21(14-24(22)28-25(26)30)20-8-10-23(11-9-20)31-16-19-4-2-1-3-5-19/h1-11,14H,12-13,15-17H2,(H,28,30)
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n/an/a 5.50E+3n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443236
PNG
(7'-(3-Cyanophenyl)-2'-oxo- 1',4'-dihydro-2'H- spir...)
Show SMILES O=C1Nc2cc(ccc2CC11CCN(C1)C#N)-c1cccc(c1)C#N
Show InChI InChI=1S/C20H16N4O/c21-11-14-2-1-3-15(8-14)16-4-5-17-10-20(6-7-24(12-20)13-22)19(25)23-18(17)9-16/h1-5,8-9H,6-7,10,12H2,(H,23,25)
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n/an/a 5.50E+3n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443237
PNG
(7'-(1-Methyl-1H-pyrazol-5- yl)-2'-oxo-1',4'-dihydr...)
Show SMILES Cn1nccc1-c1ccc2CC3(CCN(C3)C#N)C(=O)Nc2c1
Show InChI InChI=1S/C17H17N5O/c1-21-15(4-6-19-21)12-2-3-13-9-17(5-7-22(10-17)11-18)16(23)20-14(13)8-12/h2-4,6,8H,5,7,9-10H2,1H3,(H,20,23)
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443240
PNG
(7'-(4-Cyanophenyl)-2'-oxo- 1',4'-dihydro-2'H- spir...)
Show SMILES O=C1Nc2cc(ccc2CC11CCN(C1)C#N)-c1ccc(cc1)C#N
Show InChI InChI=1S/C20H16N4O/c21-11-14-1-3-15(4-2-14)16-5-6-17-10-20(7-8-24(12-20)13-22)19(25)23-18(17)9-16/h1-6,9H,7-8,10,12H2,(H,23,25)
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443282
PNG
(US10654853, Example 55)
Show SMILES O=C1Nc2cccnc2NC11CCN(C1)C#N
Show InChI InChI=1S/C11H11N5O/c12-7-16-5-3-11(6-16)10(17)14-8-2-1-4-13-9(8)15-11/h1-2,4H,3,5-6H2,(H,13,15)(H,14,17)
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MISSION THERAPEUTICS LIMITED

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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443303
PNG
((8R)-8-Methyl-7,10-dioxo-2,6,9-triazaspiro[4.5]dec...)
Show SMILES C[C@H]1NC(=O)C2(CCN(C2)C#N)NC1=O
Show InChI InChI=1S/C9H12N4O2/c1-6-7(14)12-9(8(15)11-6)2-3-13(4-9)5-10/h6H,2-4H2,1H3,(H,11,15)(H,12,14)/t6-,9?/m1/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443312
PNG
(2-Oxo-1,5-dihydro-2H-spiro[benzo[e][1,4]oxazepine-...)
Show SMILES O=C1Nc2ccccc2COC11CCN(C1)C#N
Show InChI InChI=1S/C13H13N3O2/c14-9-16-6-5-13(8-16)12(17)15-11-4-2-1-3-10(11)7-18-13/h1-4H,5-8H2,(H,15,17)
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443315
PNG
(2'-Oxo-7'-(3- (trifluoromethoxy)phenyl)- 1',4'-dih...)
Show SMILES FC(F)(F)Oc1cccc(c1)-c1ccc2CC3(CCN(C3)C#N)C(=O)Nc2c1
Show InChI InChI=1S/C20H16F3N3O2/c21-20(22,23)28-16-3-1-2-13(8-16)14-4-5-15-10-19(6-7-26(11-19)12-24)18(27)25-17(15)9-14/h1-5,8-9H,6-7,10-11H2,(H,25,27)
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443318
PNG
(7'-(1-Methyl-1H-pyrrol-2-yl)- 2'-oxo-1',4'-dihydro...)
Show SMILES Cn1cccc1-c1ccc2CC3(CCN(C3)C#N)C(=O)Nc2c1
Show InChI InChI=1S/C18H18N4O/c1-21-7-2-3-16(21)13-4-5-14-10-18(6-8-22(11-18)12-19)17(23)20-15(14)9-13/h2-5,7,9H,6,8,10-11H2,1H3,(H,20,23)
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443264
PNG
(7'-(4-(Morpholine-4- carbonyl)phenyl)-2'-oxo-1',4'...)
Show SMILES O=C(N1CCOCC1)c1ccc(cc1)-c1ccc2CC3(CCN(C3)C#N)C(=O)Nc2c1
Show InChI InChI=1S/C24H24N4O3/c25-16-27-8-7-24(15-27)14-20-6-5-19(13-21(20)26-23(24)30)17-1-3-18(4-2-17)22(29)28-9-11-31-12-10-28/h1-6,13H,7-12,14-15H2,(H,26,30)
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n/an/a 5.50E+3n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443290
PNG
((R)-6-Oxo-2,7-diazaspiro[4.4]nonane-2-carbonitrile...)
Show SMILES O=C1NCC[C@]11CCN(C1)C#N
Show InChI InChI=1S/C8H11N3O/c9-6-11-4-2-8(5-11)1-3-10-7(8)12/h1-5H2,(H,10,12)/t8-/m1/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443219
PNG
(US10654853, Example 1)
Show SMILES O=C1Nc2ccccc2CC11CCN(C1)C#N
Show InChI InChI=1S/C13H13N3O/c14-9-16-6-5-13(8-16)7-10-3-1-2-4-11(10)15-12(13)17/h1-4H,5-8H2,(H,15,17)
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443233
PNG
(7'-([1,1'-Biphenyl]-4-yl)-2'- oxo-1',4'-dihydro-2'...)
Show SMILES O=C1Nc2cc(ccc2CC11CCN(C1)C#N)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C25H21N3O/c26-17-28-13-12-25(16-28)15-22-11-10-21(14-23(22)27-24(25)29)20-8-6-19(7-9-20)18-4-2-1-3-5-18/h1-11,14H,12-13,15-16H2,(H,27,29)
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443259
PNG
(7'-(4- (Morpholinosulfonyl)phenyl)- 2'-oxo-1',4'-d...)
Show SMILES O=C1Nc2cc(ccc2CC11CCN(C1)C#N)-c1ccc(cc1)S(=O)(=O)N1CCOCC1
Show InChI InChI=1S/C23H24N4O4S/c24-16-26-8-7-23(15-26)14-19-2-1-18(13-21(19)25-22(23)28)17-3-5-20(6-4-17)32(29,30)27-9-11-31-12-10-27/h1-6,13H,7-12,14-15H2,(H,25,28)
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443260
PNG
(7'-(3,5-Dimethyl-1H-pyrazol- 4-yl)-2'-oxo-1',4'-di...)
Show SMILES Cc1n[nH]c(C)c1-c1ccc2CC3(CCN(C3)C#N)C(=O)Nc2c1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443261
PNG
(7'-(2-Methylpyridin-4-yl)-2'- oxo-1',4'-dihydro-2'...)
Show SMILES Cc1cc(ccn1)-c1ccc2CC3(CCN(C3)C#N)C(=O)Nc2c1
Show InChI InChI=1S/C19H18N4O/c1-13-8-15(4-6-21-13)14-2-3-16-10-19(5-7-23(11-19)12-20)18(24)22-17(16)9-14/h2-4,6,8-9H,5,7,10-11H2,1H3,(H,22,24)
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443308
PNG
(8-Benzyl-6-oxo-2,7-diazaspiro[4.4]nonane-2-carboni...)
Show SMILES O=C1NC(Cc2ccccc2)CC11CCN(C1)C#N
Show InChI InChI=1S/C15H17N3O/c16-11-18-7-6-15(10-18)9-13(17-14(15)19)8-12-4-2-1-3-5-12/h1-5,13H,6-10H2,(H,17,19)
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n/an/a 5.50E+3n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443319
PNG
(6'-([1,1'-Biphenyl]-4-yl)-2'-oxo-1',4'- dihydro-2'...)
Show SMILES O=C1Nc2ccc(cc2CC11CCN(C1)C#N)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C25H21N3O/c26-17-28-13-12-25(16-28)15-22-14-21(10-11-23(22)27-24(25)29)20-8-6-19(7-9-20)18-4-2-1-3-5-18/h1-11,14H,12-13,15-16H2,(H,27,29)
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443309
PNG
(US10654853, Example 82 | US10654853, Example 83)
Show SMILES CC1CC2(CCN(C2)C#N)C(=O)N1
Show InChI InChI=1S/C9H13N3O/c1-7-4-9(8(13)11-7)2-3-12(5-9)6-10/h7H,2-5H2,1H3,(H,11,13)
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n/an/a>1.00E+4n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443289
PNG
(6-Oxo-2,7-diazaspiro[4.4]nonane-2-carbonitrile | U...)
Show SMILES O=C1NCCC11CCN(C1)C#N
Show InChI InChI=1S/C8H11N3O/c9-6-11-4-2-8(5-11)1-3-10-7(8)12/h1-5H2,(H,10,12)
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443309
PNG
(US10654853, Example 82 | US10654853, Example 83)
Show SMILES CC1CC2(CCN(C2)C#N)C(=O)N1
Show InChI InChI=1S/C9H13N3O/c1-7-4-9(8(13)11-7)2-3-12(5-9)6-10/h7H,2-5H2,1H3,(H,11,13)
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443311
PNG
(6-Oxo-8-phenyl-2,7-diazaspiro[4.4]nonane-2-carboni...)
Show SMILES O=C1NC(CC11CCN(C1)C#N)c1ccccc1
Show InChI InChI=1S/C14H15N3O/c15-10-17-7-6-14(9-17)8-12(16-13(14)18)11-4-2-1-3-5-11/h1-5,12H,6-9H2,(H,16,18)
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MISSION THERAPEUTICS LIMITED

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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
OTU domain-containing protein 7B


(Human)
BDBM443307
PNG
(8-Ethyl-6-oxo-2,7-diazaspiro[4.4]nonane-2-carbonit...)
Show SMILES CCC1CC2(CCN(C2)C#N)C(=O)N1
Show InChI InChI=1S/C10H15N3O/c1-2-8-5-10(9(14)12-8)3-4-13(6-10)7-11/h8H,2-6H2,1H3,(H,12,14)
PDB

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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10654853 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%