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Patent code US10654860

Compile Data Set for Download or QSAR
Found 35 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM443399
PNG
(US10654860, Example 8)
Show SMILES COc1cccc(CN2CCN(C2=O)c2ccc3-c4c[nH]nc4CCc3n2)c1
Show InChI InChI=1S/C21H21N5O2/c1-28-15-4-2-3-14(11-15)13-25-9-10-26(21(25)27)20-8-5-16-17-12-22-24-19(17)7-6-18(16)23-20/h2-5,8,11-12H,6-7,9-10,13H2,1H3,(H,22,24)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL, assay containing 20 mM HEPES, pH 7.5, 2...


US Patent US10654860 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM443392
PNG
((rac)-1''-(4,5-dihydro-2H-benzo[e]indazol-7-yl)spi...)
Show SMILES O=C1N(CCC11Cc2ccccc2N1)c1ccc2-c3c[nH]nc3CCc2c1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL, assay containing 20 mM HEPES, pH 7.5, 2...


US Patent US10654860 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM443393
PNG
(1-(4,5-dihydro-2H-benzo[e]indazol-7-yl)-3-(3-metho...)
Show SMILES COc1cccc(CN2CCN(C2=O)c2ccc3-c4c[nH]nc4CCc3c2)c1
Show InChI InChI=1S/C22H22N4O2/c1-28-18-4-2-3-15(11-18)14-25-9-10-26(22(25)27)17-6-7-19-16(12-17)5-8-21-20(19)13-23-24-21/h2-4,6-7,11-13H,5,8-10,14H2,1H3,(H,23,24)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL, assay containing 20 mM HEPES, pH 7.5, 2...


US Patent US10654860 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM443405
PNG
(US10654860, Example 14)
Show SMILES COc1cccc(CN2CCN(C2=O)c2ccc3-c4c[nH]nc4COc3c2)c1
Show InChI InChI=1S/C21H20N4O3/c1-27-16-4-2-3-14(9-16)12-24-7-8-25(21(24)26)15-5-6-17-18-11-22-23-19(18)13-28-20(17)10-15/h2-6,9-11H,7-8,12-13H2,1H3,(H,22,23)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL, assay containing 20 mM HEPES, pH 7.5, 2...


US Patent US10654860 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM443400
PNG
(US10654860, Example 9)
Show SMILES COc1cccc(N[C@@H]2CCN(C2=O)c2ccc3-c4c[nH]nc4CCc3c2)c1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL, assay containing 20 mM HEPES, pH 7.5, 2...


US Patent US10654860 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM443394
PNG
((S)-1-(4,5-dihydro-21-benzo[e]indazol-7-yl)-3-((3-...)
Show SMILES COc1cccc(N[C@H]2CCN(C2=O)c2ccc3-c4c[nH]nc4CCc3c2)c1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL, assay containing 20 mM HEPES, pH 7.5, 2...


US Patent US10654860 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM443406
PNG
(US10654860, Example 15)
Show SMILES COc1cccc(CN2CCN(C2=O)c2ccc3-c4c[nH]nc4COc3n2)c1
Show InChI InChI=1S/C20H19N5O3/c1-27-14-4-2-3-13(9-14)11-24-7-8-25(20(24)26)18-6-5-15-16-10-21-23-17(16)12-28-19(15)22-18/h2-6,9-10H,7-8,11-12H2,1H3,(H,21,23)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL, assay containing 20 mM HEPES, pH 7.5, 2...


US Patent US10654860 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM443395
PNG
((R)-2-amino-N-(4,5-dihydro-2H-benzo[e]indazol-7-yl...)
Show SMILES N[C@H](CCc1ccccc1)C(=O)Nc1ccc2-c3c[nH]nc3CCc2c1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL, assay containing 20 mM HEPES, pH 7.5, 2...


US Patent US10654860 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM443398
PNG
(US10654860, Example 7)
Show SMILES COc1cccc(c1)[C@@H](C)N1CCN(C1=O)c1ccc2-c3c[nH]nc3CCc2c1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL, assay containing 20 mM HEPES, pH 7.5, 2...


US Patent US10654860 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM443401
PNG
(US10654860, Example 10 | US10654860, Example 13 | ...)
Show SMILES COc1cccc(NC2CCN(C2=O)c2ccc3-c4c[nH]nc4COc3c2)c1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL, assay containing 20 mM HEPES, pH 7.5, 2...


US Patent US10654860 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM443401
PNG
(US10654860, Example 10 | US10654860, Example 13 | ...)
Show SMILES COc1cccc(NC2CCN(C2=O)c2ccc3-c4c[nH]nc4COc3c2)c1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL, assay containing 20 mM HEPES, pH 7.5, 2...


US Patent US10654860 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM443392
PNG
((rac)-1''-(4,5-dihydro-2H-benzo[e]indazol-7-yl)spi...)
Show SMILES O=C1N(CCC11Cc2ccccc2N1)c1ccc2-c3c[nH]nc3CCc2c1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL, assay containing 20 mM HEPES, pH 7.5, 2...


US Patent US10654860 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM443413
PNG
(US10654860, Example 22)
Show SMILES Cc1c(F)cccc1CN1CCN(C1=O)c1ccc2-c3c[nH]nc3COc2n1
Show InChI InChI=1S/C20H18FN5O2/c1-12-13(3-2-4-16(12)21)10-25-7-8-26(20(25)27)18-6-5-14-15-9-22-24-17(15)11-28-19(14)23-18/h2-6,9H,7-8,10-11H2,1H3,(H,22,24)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL, assay containing 20 mM HEPES, pH 7.5, 2...


US Patent US10654860 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM443412
PNG
(US10654860, Example 21)
Show SMILES Fc1cc(F)cc(CN2CCN(C2=O)c2ccc3-c4c[nH]nc4COc3n2)c1
Show InChI InChI=1S/C19H15F2N5O2/c20-12-5-11(6-13(21)7-12)9-25-3-4-26(19(25)27)17-2-1-14-15-8-22-24-16(15)10-28-18(14)23-17/h1-2,5-8H,3-4,9-10H2,(H,22,24)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL, assay containing 20 mM HEPES, pH 7.5, 2...


US Patent US10654860 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM443402
PNG
(US10654860, Example 11)
Show SMILES COc1cccc(NC2CCN(C2=O)c2ccc3-c4c[nH]nc4COc3n2)c1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL, assay containing 20 mM HEPES, pH 7.5, 2...


US Patent US10654860 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM443410
PNG
(US10654860, Example 19)
Show SMILES COc1cccc(CN2CCN(C2=O)c2ccc3-c4c(C)[nH]nc4CCc3c2)c1
Show InChI InChI=1S/C23H24N4O2/c1-15-22-20-8-7-18(13-17(20)6-9-21(22)25-24-15)27-11-10-26(23(27)28)14-16-4-3-5-19(12-16)29-2/h3-5,7-8,12-13H,6,9-11,14H2,1-2H3,(H,24,25)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL, assay containing 20 mM HEPES, pH 7.5, 2...


US Patent US10654860 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM443409
PNG
(US10654860, Example 18)
Show SMILES COc1cc(F)cc(CN2CCN(C2=O)c2ccc3-c4c[nH]nc4COc3n2)c1
Show InChI InChI=1S/C20H18FN5O3/c1-28-14-7-12(6-13(21)8-14)10-25-4-5-26(20(25)27)18-3-2-15-16-9-22-24-17(16)11-29-19(15)23-18/h2-3,6-9H,4-5,10-11H2,1H3,(H,22,24)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL, assay containing 20 mM HEPES, pH 7.5, 2...


US Patent US10654860 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM443411
PNG
(US10654860, Example 20)
Show SMILES Cc1ccc(F)c(CN2CCN(C2=O)c2ccc3-c4c[nH]nc4COc3n2)c1
Show InChI InChI=1S/C20H18FN5O2/c1-12-2-4-16(21)13(8-12)10-25-6-7-26(20(25)27)18-5-3-14-15-9-22-24-17(15)11-28-19(14)23-18/h2-5,8-9H,6-7,10-11H2,1H3,(H,22,24)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL, assay containing 20 mM HEPES, pH 7.5, 2...


US Patent US10654860 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM443401
PNG
(US10654860, Example 10 | US10654860, Example 13 | ...)
Show SMILES COc1cccc(NC2CCN(C2=O)c2ccc3-c4c[nH]nc4COc3c2)c1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL, assay containing 20 mM HEPES, pH 7.5, 2...


US Patent US10654860 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM443392
PNG
((rac)-1''-(4,5-dihydro-2H-benzo[e]indazol-7-yl)spi...)
Show SMILES O=C1N(CCC11Cc2ccccc2N1)c1ccc2-c3c[nH]nc3CCc2c1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL, assay containing 20 mM HEPES, pH 7.5, 2...


US Patent US10654860 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM443414
PNG
(US10654860, Example 23)
Show SMILES NC(=O)c1cccc(CN2CCN(C2=O)c2ccc3-c4c[nH]nc4COc3n2)c1
Show InChI InChI=1S/C20H18N6O3/c21-18(27)13-3-1-2-12(8-13)10-25-6-7-26(20(25)28)17-5-4-14-15-9-22-24-16(15)11-29-19(14)23-17/h1-5,8-9H,6-7,10-11H2,(H2,21,27)(H,22,24)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL, assay containing 20 mM HEPES, pH 7.5, 2...


US Patent US10654860 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM443403
PNG
(US10654860, Example 12)
Show SMILES COc1cc(F)cc(NC2CCN(C2=O)c2ccc3-c4c[nH]nc4COc3n2)c1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL, assay containing 20 mM HEPES, pH 7.5, 2...


US Patent US10654860 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM443396
PNG
(1-(2,4-dihydropyrazolo[4',3':4,5]pyrano[2,3-b]pyri...)
Show SMILES COc1cccc(CNC(=O)Nc2ccc3-c4c[nH]nc4COc3n2)c1
Show InChI InChI=1S/C18H17N5O3/c1-25-12-4-2-3-11(7-12)8-19-18(24)22-16-6-5-13-14-9-20-23-15(14)10-26-17(13)21-16/h2-7,9H,8,10H2,1H3,(H,20,23)(H2,19,21,22,24)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL, assay containing 20 mM HEPES, pH 7.5, 2...


US Patent US10654860 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM443421
PNG
(US10654860, Example 29)
Show SMILES Fc1ccc(CN2CCN(C2=O)c2ccc3-c4c[nH]nc4COc3n2)cc1F
Show InChI InChI=1S/C19H15F2N5O2/c20-14-3-1-11(7-15(14)21)9-25-5-6-26(19(25)27)17-4-2-12-13-8-22-24-16(13)10-28-18(12)23-17/h1-4,7-8H,5-6,9-10H2,(H,22,24)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL, assay containing 20 mM HEPES, pH 7.5, 2...


US Patent US10654860 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM443420
PNG
(US10654860, Example 28)
Show SMILES Cc1cc(F)ccc1CN1CCN(C1=O)c1ccc2-c3c[nH]nc3COc2n1
Show InChI InChI=1S/C20H18FN5O2/c1-12-8-14(21)3-2-13(12)10-25-6-7-26(20(25)27)18-5-4-15-16-9-22-24-17(16)11-28-19(15)23-18/h2-5,8-9H,6-7,10-11H2,1H3,(H,22,24)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL, assay containing 20 mM HEPES, pH 7.5, 2...


US Patent US10654860 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM443417
PNG
(US10654860, Example 25)
Show SMILES Fc1cccc(CN2CCN(C2=O)c2ccc3-c4c[nH]nc4COc3n2)c1
Show InChI InChI=1S/C19H16FN5O2/c20-13-3-1-2-12(8-13)10-24-6-7-25(19(24)26)17-5-4-14-15-9-21-23-16(15)11-27-18(14)22-17/h1-5,8-9H,6-7,10-11H2,(H,21,23)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL, assay containing 20 mM HEPES, pH 7.5, 2...


US Patent US10654860 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM443422
PNG
(US10654860, Example 30)
Show SMILES Fc1ccc(F)c(CN2CCN(C2=O)c2ccc3-c4c[nH]nc4COc3n2)c1
Show InChI InChI=1S/C19H15F2N5O2/c20-12-1-3-15(21)11(7-12)9-25-5-6-26(19(25)27)17-4-2-13-14-8-22-24-16(14)10-28-18(13)23-17/h1-4,7-8H,5-6,9-10H2,(H,22,24)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL, assay containing 20 mM HEPES, pH 7.5, 2...


US Patent US10654860 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM443419
PNG
(US10654860, Example 27)
Show SMILES COc1cccc(CN2CCN(C2=O)c2ccc3-c4c[nH]nc4COc3n2)c1F
Show InChI InChI=1S/C20H18FN5O3/c1-28-16-4-2-3-12(18(16)21)10-25-7-8-26(20(25)27)17-6-5-13-14-9-22-24-15(14)11-29-19(13)23-17/h2-6,9H,7-8,10-11H2,1H3,(H,22,24)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL, assay containing 20 mM HEPES, pH 7.5, 2...


US Patent US10654860 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM443416
PNG
(US10654860, Example 24)
Show SMILES Cc1c(F)cccc1NC1CCN(C1=O)c1ccc2-c3c[nH]nc3COc2n1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL, assay containing 20 mM HEPES, pH 7.5, 2...


US Patent US10654860 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM443418
PNG
(US10654860, Example 26)
Show SMILES Cc1cc(CN2CCN(C2=O)c2ccc3-c4c[nH]nc4COc3n2)ccc1F
Show InChI InChI=1S/C20H18FN5O2/c1-12-8-13(2-4-16(12)21)10-25-6-7-26(20(25)27)18-5-3-14-15-9-22-24-17(15)11-28-19(14)23-18/h2-5,8-9H,6-7,10-11H2,1H3,(H,22,24)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL, assay containing 20 mM HEPES, pH 7.5, 2...


US Patent US10654860 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM443427
PNG
(US10654860, Example 35)
Show SMILES O=C1C(CCN1c1ccc2-c3c[nH]nc3COc2n1)Nc1cccc(c1)-c1cnco1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL, assay containing 20 mM HEPES, pH 7.5, 2...


US Patent US10654860 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM443423
PNG
(US10654860, Example 31)
Show SMILES CC(C)(C)c1cccc(CN2CCN(C2=O)c2ccc3-c4c[nH]nc4COc3n2)c1
Show InChI InChI=1S/C23H25N5O2/c1-23(2,3)16-6-4-5-15(11-16)13-27-9-10-28(22(27)29)20-8-7-17-18-12-24-26-19(18)14-30-21(17)25-20/h4-8,11-12H,9-10,13-14H2,1-3H3,(H,24,26)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL, assay containing 20 mM HEPES, pH 7.5, 2...


US Patent US10654860 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM443426
PNG
(US10654860, Example 34)
Show SMILES O=C1C(CCN1c1ccc2-c3c[nH]nc3COc2n1)Nc1cccc(c1)C#N
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL, assay containing 20 mM HEPES, pH 7.5, 2...


US Patent US10654860 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM443424
PNG
(US10654860, Example 32)
Show SMILES O=C1C(CCN1c1ccc2-c3c[nH]nc3COc2n1)Nc1ccc2ncsc2c1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL, assay containing 20 mM HEPES, pH 7.5, 2...


US Patent US10654860 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM443425
PNG
(US10654860, Example 33)
Show SMILES Fc1cccc(F)c1CN1CCN(C1=O)c1ccc2-c3c[nH]nc3COc2n1
Show InChI InChI=1S/C19H15F2N5O2/c20-14-2-1-3-15(21)13(14)9-25-6-7-26(19(25)27)17-5-4-11-12-8-22-24-16(12)10-28-18(11)23-17/h1-5,8H,6-7,9-10H2,(H,22,24)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL, assay containing 20 mM HEPES, pH 7.5, 2...


US Patent US10654860 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%