BindingDB logo
myBDB logout

Patent code US10654866

Compile Data Set for Download or QSAR
Found 44 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Baculoviral IAP repeat-containing protein 2/Estrogen receptor


(Homo sapiens (Human))
BDBM443430
PNG
(US10654866, Example 1B)
Show SMILES Oc1ccc2c3[C@@H](Oc4cc(ccc4-c3cnc2c1)C(F)(F)F)c1ccc(OCCN2CC(CF)C2)cc1
Show InChI InChI=1S/C29H24F4N2O3/c30-13-17-15-35(16-17)9-10-37-21-5-1-18(2-6-21)28-27-23-8-4-20(36)12-25(23)34-14-24(27)22-7-3-19(29(31,32)33)11-26(22)38-28/h1-8,11-12,14,17,28,36H,9-10,13,15-16H2/t28-/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
UniChem
US Patent
0.310n/an/an/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...


US Patent US10654866 (2020)

More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2/Estrogen receptor


(Homo sapiens (Human))
BDBM443444
PNG
(US10654866, Example 4B)
Show SMILES Oc1ccc2c3[C@@H](Oc4c(Cl)cccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1
Show InChI InChI=1S/C28H24ClFN2O3/c29-24-3-1-2-21-23-14-31-25-12-19(33)6-9-22(25)26(23)27(35-28(21)24)18-4-7-20(8-5-18)34-11-10-32-15-17(13-30)16-32/h1-9,12,14,17,27,33H,10-11,13,15-16H2/t27-/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
UniChem
US Patent
0.340n/an/an/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...


US Patent US10654866 (2020)

More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2/Estrogen receptor


(Homo sapiens (Human))
BDBM443449
PNG
(US10654866, Example 3B)
Show SMILES Oc1ccc2c3[C@@H](Oc4cc(Cl)ccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1
Show InChI InChI=1S/C28H24ClFN2O3/c29-19-3-7-22-24-14-31-25-12-20(33)4-8-23(25)27(24)28(35-26(22)11-19)18-1-5-21(6-2-18)34-10-9-32-15-17(13-30)16-32/h1-8,11-12,14,17,28,33H,9-10,13,15-16H2/t28-/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
UniChem
US Patent
0.590n/an/an/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...


US Patent US10654866 (2020)

More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2/Estrogen receptor


(Homo sapiens (Human))
BDBM443450
PNG
(US10654866, Example 4)
Show SMILES Oc1ccc2c3C(Oc4c(Cl)cccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1
Show InChI InChI=1S/C28H24ClFN2O3/c29-24-3-1-2-21-23-14-31-25-12-19(33)6-9-22(25)26(23)27(35-28(21)24)18-4-7-20(8-5-18)34-11-10-32-15-17(13-30)16-32/h1-9,12,14,17,27,33H,10-11,13,15-16H2
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
UniChem
US Patent
0.640n/an/an/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...


US Patent US10654866 (2020)

More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2/Estrogen receptor


(Homo sapiens (Human))
BDBM443433
PNG
(US10654866, Example 2A)
Show SMILES Oc1ccc2c3[C@H](Oc4c(cccc4C(F)(F)F)-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1
Show InChI InChI=1S/C29H24F4N2O3/c30-13-17-15-35(16-17)10-11-37-20-7-4-18(5-8-20)27-26-22-9-6-19(36)12-25(22)34-14-23(26)21-2-1-3-24(28(21)38-27)29(31,32)33/h1-9,12,14,17,27,36H,10-11,13,15-16H2/t27-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
UniChem
US Patent
0.650n/an/an/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...


US Patent US10654866 (2020)

More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2/Estrogen receptor


(Homo sapiens (Human))
BDBM443428
PNG
(Racemic 5-(4-{2-[3-(Fluoromethyl)azetidin-1-yl]eth...)
Show SMILES Oc1ccc2c3C(Oc4cc(ccc4-c3cnc2c1)C(F)(F)F)c1ccc(OCCN2CC(CF)C2)cc1
Show InChI InChI=1S/C29H24F4N2O3/c30-13-17-15-35(16-17)9-10-37-21-5-1-18(2-6-21)28-27-23-8-4-20(36)12-25(23)34-14-24(27)22-7-3-19(29(31,32)33)11-26(22)38-28/h1-8,11-12,14,17,28,36H,9-10,13,15-16H2
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
UniChem
US Patent
0.870n/an/an/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...


US Patent US10654866 (2020)

More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2/Estrogen receptor


(Homo sapiens (Human))
BDBM443443
PNG
(US10654866, Example 8B)
Show SMILES Cc1cccc-2c1O[C@H](c1ccc(OCCN3CC(CF)C3)cc1)c1c-2cnc2cc(O)ccc12
Show InChI InChI=1S/C29H27FN2O3/c1-18-3-2-4-23-25-15-31-26-13-21(33)7-10-24(26)27(25)29(35-28(18)23)20-5-8-22(9-6-20)34-12-11-32-16-19(14-30)17-32/h2-10,13,15,19,29,33H,11-12,14,16-17H2,1H3/t29-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
UniChem
US Patent
0.940n/an/an/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...


US Patent US10654866 (2020)

More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2/Estrogen receptor


(Homo sapiens (Human))
BDBM443448
PNG
(US10654866, Example 6B)
Show SMILES Oc1ccc2c3[C@@H](Oc4c(F)cccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1
Show InChI InChI=1S/C28H24F2N2O3/c29-13-17-15-32(16-17)10-11-34-20-7-4-18(5-8-20)27-26-22-9-6-19(33)12-25(22)31-14-23(26)21-2-1-3-24(30)28(21)35-27/h1-9,12,14,17,27,33H,10-11,13,15-16H2/t27-/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
UniChem
US Patent
1.13n/an/an/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...


US Patent US10654866 (2020)

More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2/Estrogen receptor


(Homo sapiens (Human))
BDBM443446
PNG
(US10654866, Example 5B)
Show SMILES Oc1ccc2c3[C@@H](Oc4cc(F)ccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1
Show InChI InChI=1S/C28H24F2N2O3/c29-13-17-15-32(16-17)9-10-34-21-5-1-18(2-6-21)28-27-23-8-4-20(33)12-25(23)31-14-24(27)22-7-3-19(30)11-26(22)35-28/h1-8,11-12,14,17,28,33H,9-10,13,15-16H2/t28-/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
UniChem
US Patent
1.30n/an/an/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...


US Patent US10654866 (2020)

More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2/Estrogen receptor


(Homo sapiens (Human))
BDBM443440
PNG
(US10654866, Example 7)
Show SMILES Cc1ccc-2c(OC(c3ccc(OCCN4CC(CF)C4)cc3)c3c-2cnc2cc(O)ccc32)c1
Show InChI InChI=1S/C29H27FN2O3/c1-18-2-8-23-25-15-31-26-13-21(33)5-9-24(26)28(25)29(35-27(23)12-18)20-3-6-22(7-4-20)34-11-10-32-16-19(14-30)17-32/h2-9,12-13,15,19,29,33H,10-11,14,16-17H2,1H3
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
UniChem
US Patent
1.55n/an/an/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...


US Patent US10654866 (2020)

More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2/Estrogen receptor


(Homo sapiens (Human))
BDBM443432
PNG
(Racemic 5-(4-{2- [3-(fluoromethyl) azetidin-1- yl]...)
Show SMILES Oc1ccc2c3C(Oc4c(cccc4C(F)(F)F)-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1
Show InChI InChI=1S/C29H24F4N2O3/c30-13-17-15-35(16-17)10-11-37-20-7-4-18(5-8-20)27-26-22-9-6-19(36)12-25(22)34-14-23(26)21-2-1-3-24(28(21)38-27)29(31,32)33/h1-9,12,14,17,27,36H,10-11,13,15-16H2
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
UniChem
US Patent
2.17n/an/an/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...


US Patent US10654866 (2020)

More data for this
Ligand-Target Pair
Estrogen receptor alpha Y537S


(Homo sapiens (Human))
BDBM443444
PNG
(US10654866, Example 4B)
Show SMILES Oc1ccc2c3[C@@H](Oc4c(Cl)cccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1
Show InChI InChI=1S/C28H24ClFN2O3/c29-24-3-1-2-21-23-14-31-25-12-19(33)6-9-22(25)26(23)27(35-28(21)24)18-4-7-20(8-5-18)34-11-10-32-15-17(13-30)16-32/h1-9,12,14,17,27,33H,10-11,13,15-16H2/t27-/m0/s1
PDB

GoogleScholar
UniChem
US Patent
2.34n/an/an/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...


US Patent US10654866 (2020)

More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2/Estrogen receptor


(Homo sapiens (Human))
BDBM443435
PNG
(US10654866, Example 3 | US10654866, Example 3A)
Show SMILES Oc1ccc2c3C(Oc4cc(Cl)ccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1
Show InChI InChI=1S/C28H24ClFN2O3/c29-19-3-7-22-24-14-31-25-12-20(33)4-8-23(25)27(24)28(35-26(22)11-19)18-1-5-21(6-2-18)34-10-9-32-15-17(13-30)16-32/h1-8,11-12,14,17,28,33H,9-10,13,15-16H2
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
UniChem
US Patent
2.36n/an/an/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...


US Patent US10654866 (2020)

More data for this
Ligand-Target Pair
Estrogen receptor alpha Y537S


(Homo sapiens (Human))
BDBM443430
PNG
(US10654866, Example 1B)
Show SMILES Oc1ccc2c3[C@@H](Oc4cc(ccc4-c3cnc2c1)C(F)(F)F)c1ccc(OCCN2CC(CF)C2)cc1
Show InChI InChI=1S/C29H24F4N2O3/c30-13-17-15-35(16-17)9-10-37-21-5-1-18(2-6-21)28-27-23-8-4-20(36)12-25(23)34-14-24(27)22-7-3-19(29(31,32)33)11-26(22)38-28/h1-8,11-12,14,17,28,36H,9-10,13,15-16H2/t28-/m0/s1
PDB

GoogleScholar
UniChem
US Patent
2.79n/an/an/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...


US Patent US10654866 (2020)

More data for this
Ligand-Target Pair
Estrogen receptor alpha Y537S


(Homo sapiens (Human))
BDBM443449
PNG
(US10654866, Example 3B)
Show SMILES Oc1ccc2c3[C@@H](Oc4cc(Cl)ccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1
Show InChI InChI=1S/C28H24ClFN2O3/c29-19-3-7-22-24-14-31-25-12-20(33)4-8-23(25)27(24)28(35-26(22)11-19)18-1-5-21(6-2-18)34-10-9-32-15-17(13-30)16-32/h1-8,11-12,14,17,28,33H,9-10,13,15-16H2/t28-/m0/s1
PDB

GoogleScholar
UniChem
US Patent
2.79n/an/an/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...


US Patent US10654866 (2020)

More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2/Estrogen receptor


(Homo sapiens (Human))
BDBM443438
PNG
(US10654866, Example 5)
Show SMILES Oc1ccc2c3C(Oc4cc(F)ccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1
Show InChI InChI=1S/C28H24F2N2O3/c29-13-17-15-32(16-17)9-10-34-21-5-1-18(2-6-21)28-27-23-8-4-20(33)12-25(23)31-14-24(27)22-7-3-19(30)11-26(22)35-28/h1-8,11-12,14,17,28,33H,9-10,13,15-16H2
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
UniChem
US Patent
2.82n/an/an/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...


US Patent US10654866 (2020)

More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2/Estrogen receptor


(Homo sapiens (Human))
BDBM443441
PNG
(US10654866, Example 8)
Show SMILES Cc1cccc-2c1OC(c1ccc(OCCN3CC(CF)C3)cc1)c1c-2cnc2cc(O)ccc12
Show InChI InChI=1S/C29H27FN2O3/c1-18-3-2-4-23-25-15-31-26-13-21(33)7-10-24(26)27(25)29(35-28(18)23)20-5-8-22(9-6-20)34-12-11-32-16-19(14-30)17-32/h2-10,13,15,19,29,33H,11-12,14,16-17H2,1H3
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
UniChem
US Patent
3.20n/an/an/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...


US Patent US10654866 (2020)

More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2/Estrogen receptor


(Homo sapiens (Human))
BDBM443439
PNG
(US10654866, Example 6)
Show SMILES Oc1ccc2c3C(Oc4c(F)cccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1
Show InChI InChI=1S/C28H24F2N2O3/c29-13-17-15-32(16-17)10-11-34-20-7-4-18(5-8-20)27-26-22-9-6-19(33)12-25(22)31-14-23(26)21-2-1-3-24(30)28(21)35-27/h1-9,12,14,17,27,33H,10-11,13,15-16H2
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
UniChem
US Patent
4.14n/an/an/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...


US Patent US10654866 (2020)

More data for this
Ligand-Target Pair
Estrogen receptor alpha Y537S


(Homo sapiens (Human))
BDBM443443
PNG
(US10654866, Example 8B)
Show SMILES Cc1cccc-2c1O[C@H](c1ccc(OCCN3CC(CF)C3)cc1)c1c-2cnc2cc(O)ccc12
Show InChI InChI=1S/C29H27FN2O3/c1-18-3-2-4-23-25-15-31-26-13-21(33)7-10-24(26)27(25)29(35-28(18)23)20-5-8-22(9-6-20)34-12-11-32-16-19(14-30)17-32/h2-10,13,15,19,29,33H,11-12,14,16-17H2,1H3/t29-/m1/s1
PDB

GoogleScholar
UniChem
US Patent
5.44n/an/an/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...


US Patent US10654866 (2020)

More data for this
Ligand-Target Pair
Estrogen receptor alpha Y537S


(Homo sapiens (Human))
BDBM443448
PNG
(US10654866, Example 6B)
Show SMILES Oc1ccc2c3[C@@H](Oc4c(F)cccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1
Show InChI InChI=1S/C28H24F2N2O3/c29-13-17-15-32(16-17)10-11-34-20-7-4-18(5-8-20)27-26-22-9-6-19(33)12-25(22)31-14-23(26)21-2-1-3-24(30)28(21)35-27/h1-9,12,14,17,27,33H,10-11,13,15-16H2/t27-/m0/s1
PDB

GoogleScholar
UniChem
US Patent
5.71n/an/an/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...


US Patent US10654866 (2020)

More data for this
Ligand-Target Pair
Estrogen receptor alpha Y537S


(Homo sapiens (Human))
BDBM443428
PNG
(Racemic 5-(4-{2-[3-(Fluoromethyl)azetidin-1-yl]eth...)
Show SMILES Oc1ccc2c3C(Oc4cc(ccc4-c3cnc2c1)C(F)(F)F)c1ccc(OCCN2CC(CF)C2)cc1
Show InChI InChI=1S/C29H24F4N2O3/c30-13-17-15-35(16-17)9-10-37-21-5-1-18(2-6-21)28-27-23-8-4-20(36)12-25(23)34-14-24(27)22-7-3-19(29(31,32)33)11-26(22)38-28/h1-8,11-12,14,17,28,36H,9-10,13,15-16H2
PDB

GoogleScholar
UniChem
US Patent
5.80n/an/an/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...


US Patent US10654866 (2020)

More data for this
Ligand-Target Pair
Estrogen receptor alpha Y537S


(Homo sapiens (Human))
BDBM443446
PNG
(US10654866, Example 5B)
Show SMILES Oc1ccc2c3[C@@H](Oc4cc(F)ccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1
Show InChI InChI=1S/C28H24F2N2O3/c29-13-17-15-32(16-17)9-10-34-21-5-1-18(2-6-21)28-27-23-8-4-20(33)12-25(23)31-14-24(27)22-7-3-19(30)11-26(22)35-28/h1-8,11-12,14,17,28,33H,9-10,13,15-16H2/t28-/m0/s1
PDB

GoogleScholar
UniChem
US Patent
6.56n/an/an/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...


US Patent US10654866 (2020)

More data for this
Ligand-Target Pair
Estrogen receptor alpha Y537S


(Homo sapiens (Human))
BDBM443435
PNG
(US10654866, Example 3 | US10654866, Example 3A)
Show SMILES Oc1ccc2c3C(Oc4cc(Cl)ccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1
Show InChI InChI=1S/C28H24ClFN2O3/c29-19-3-7-22-24-14-31-25-12-20(33)4-8-23(25)27(24)28(35-26(22)11-19)18-1-5-21(6-2-18)34-10-9-32-15-17(13-30)16-32/h1-8,11-12,14,17,28,33H,9-10,13,15-16H2
PDB

GoogleScholar
UniChem
US Patent
6.69n/an/an/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...


US Patent US10654866 (2020)

More data for this
Ligand-Target Pair
Estrogen receptor alpha Y537S


(Homo sapiens (Human))
BDBM443432
PNG
(Racemic 5-(4-{2- [3-(fluoromethyl) azetidin-1- yl]...)
Show SMILES Oc1ccc2c3C(Oc4c(cccc4C(F)(F)F)-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1
Show InChI InChI=1S/C29H24F4N2O3/c30-13-17-15-35(16-17)10-11-37-20-7-4-18(5-8-20)27-26-22-9-6-19(36)12-25(22)34-14-23(26)21-2-1-3-24(28(21)38-27)29(31,32)33/h1-9,12,14,17,27,36H,10-11,13,15-16H2
PDB

GoogleScholar
UniChem
US Patent
6.78n/an/an/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...


US Patent US10654866 (2020)

More data for this
Ligand-Target Pair
Estrogen receptor alpha Y537S


(Homo sapiens (Human))
BDBM443433
PNG
(US10654866, Example 2A)
Show SMILES Oc1ccc2c3[C@H](Oc4c(cccc4C(F)(F)F)-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1
Show InChI InChI=1S/C29H24F4N2O3/c30-13-17-15-35(16-17)10-11-37-20-7-4-18(5-8-20)27-26-22-9-6-19(36)12-25(22)34-14-23(26)21-2-1-3-24(28(21)38-27)29(31,32)33/h1-9,12,14,17,27,36H,10-11,13,15-16H2/t27-/m1/s1
PDB

GoogleScholar
UniChem
US Patent
7.92n/an/an/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...


US Patent US10654866 (2020)

More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2/Estrogen receptor


(Homo sapiens (Human))
BDBM443435
PNG
(US10654866, Example 3 | US10654866, Example 3A)
Show SMILES Oc1ccc2c3C(Oc4cc(Cl)ccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1
Show InChI InChI=1S/C28H24ClFN2O3/c29-19-3-7-22-24-14-31-25-12-20(33)4-8-23(25)27(24)28(35-26(22)11-19)18-1-5-21(6-2-18)34-10-9-32-15-17(13-30)16-32/h1-8,11-12,14,17,28,33H,9-10,13,15-16H2
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
UniChem
US Patent
8.11n/an/an/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...


US Patent US10654866 (2020)

More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2/Estrogen receptor


(Homo sapiens (Human))
BDBM443447
PNG
(US10654866, Example 6A)
Show SMILES Oc1ccc2c3[C@H](Oc4c(F)cccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1
Show InChI InChI=1S/C28H24F2N2O3/c29-13-17-15-32(16-17)10-11-34-20-7-4-18(5-8-20)27-26-22-9-6-19(33)12-25(22)31-14-23(26)21-2-1-3-24(30)28(21)35-27/h1-9,12,14,17,27,33H,10-11,13,15-16H2/t27-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
UniChem
US Patent
8.53n/an/an/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...


US Patent US10654866 (2020)

More data for this
Ligand-Target Pair
Estrogen receptor alpha Y537S


(Homo sapiens (Human))
BDBM443440
PNG
(US10654866, Example 7)
Show SMILES Cc1ccc-2c(OC(c3ccc(OCCN4CC(CF)C4)cc3)c3c-2cnc2cc(O)ccc32)c1
Show InChI InChI=1S/C29H27FN2O3/c1-18-2-8-23-25-15-31-26-13-21(33)5-9-24(26)28(25)29(35-27(23)12-18)20-3-6-22(7-4-20)34-11-10-32-16-19(14-30)17-32/h2-9,12-13,15,19,29,33H,10-11,14,16-17H2,1H3
PDB

GoogleScholar
UniChem
US Patent
8.55n/an/an/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...


US Patent US10654866 (2020)

More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2/Estrogen receptor


(Homo sapiens (Human))
BDBM443442
PNG
(US10654866, Example 8A)
Show SMILES Cc1cccc-2c1O[C@@H](c1ccc(OCCN3CC(CF)C3)cc1)c1c-2cnc2cc(O)ccc12
Show InChI InChI=1S/C29H27FN2O3/c1-18-3-2-4-23-25-15-31-26-13-21(33)7-10-24(26)27(25)29(35-28(18)23)20-5-8-22(9-6-20)34-12-11-32-16-19(14-30)17-32/h2-10,13,15,19,29,33H,11-12,14,16-17H2,1H3/t29-/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
UniChem
US Patent
9.33n/an/an/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...


US Patent US10654866 (2020)

More data for this
Ligand-Target Pair
Estrogen receptor alpha Y537S


(Homo sapiens (Human))
BDBM443441
PNG
(US10654866, Example 8)
Show SMILES Cc1cccc-2c1OC(c1ccc(OCCN3CC(CF)C3)cc1)c1c-2cnc2cc(O)ccc12
Show InChI InChI=1S/C29H27FN2O3/c1-18-3-2-4-23-25-15-31-26-13-21(33)7-10-24(26)27(25)29(35-28(18)23)20-5-8-22(9-6-20)34-12-11-32-16-19(14-30)17-32/h2-10,13,15,19,29,33H,11-12,14,16-17H2,1H3
PDB

GoogleScholar
UniChem
US Patent
11.4n/an/an/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...


US Patent US10654866 (2020)

More data for this
Ligand-Target Pair
Estrogen receptor alpha Y537S


(Homo sapiens (Human))
BDBM443450
PNG
(US10654866, Example 4)
Show SMILES Oc1ccc2c3C(Oc4c(Cl)cccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1
Show InChI InChI=1S/C28H24ClFN2O3/c29-24-3-1-2-21-23-14-31-25-12-19(33)6-9-22(25)26(23)27(35-28(21)24)18-4-7-20(8-5-18)34-11-10-32-15-17(13-30)16-32/h1-9,12,14,17,27,33H,10-11,13,15-16H2
PDB

GoogleScholar
UniChem
US Patent
12.1n/an/an/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...


US Patent US10654866 (2020)

More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2/Estrogen receptor


(Homo sapiens (Human))
BDBM443429
PNG
(US10654866, Example 1A)
Show SMILES Oc1ccc2c3[C@H](Oc4cc(ccc4-c3cnc2c1)C(F)(F)F)c1ccc(OCCN2CC(CF)C2)cc1
Show InChI InChI=1S/C29H24F4N2O3/c30-13-17-15-35(16-17)9-10-37-21-5-1-18(2-6-21)28-27-23-8-4-20(36)12-25(23)34-14-24(27)22-7-3-19(29(31,32)33)11-26(22)38-28/h1-8,11-12,14,17,28,36H,9-10,13,15-16H2/t28-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
UniChem
US Patent
12.4n/an/an/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...


US Patent US10654866 (2020)

More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2/Estrogen receptor


(Homo sapiens (Human))
BDBM443445
PNG
(US10654866, Example 5A)
Show SMILES Oc1ccc2c3[C@H](Oc4cc(F)ccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1
Show InChI InChI=1S/C28H24F2N2O3/c29-13-17-15-32(16-17)9-10-34-21-5-1-18(2-6-21)28-27-23-8-4-20(33)12-25(23)31-14-24(27)22-7-3-19(30)11-26(22)35-28/h1-8,11-12,14,17,28,33H,9-10,13,15-16H2/t28-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
UniChem
US Patent
12.5n/an/an/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...


US Patent US10654866 (2020)

More data for this
Ligand-Target Pair
Estrogen receptor alpha Y537S


(Homo sapiens (Human))
BDBM443439
PNG
(US10654866, Example 6)
Show SMILES Oc1ccc2c3C(Oc4c(F)cccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1
Show InChI InChI=1S/C28H24F2N2O3/c29-13-17-15-32(16-17)10-11-34-20-7-4-18(5-8-20)27-26-22-9-6-19(33)12-25(22)31-14-23(26)21-2-1-3-24(30)28(21)35-27/h1-9,12,14,17,27,33H,10-11,13,15-16H2
PDB

GoogleScholar
UniChem
US Patent
15.8n/an/an/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...


US Patent US10654866 (2020)

More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2/Estrogen receptor


(Homo sapiens (Human))
BDBM443437
PNG
(US10654866, Example 4A)
Show SMILES Oc1ccc2c3[C@H](Oc4c(Cl)cccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1
Show InChI InChI=1S/C28H24ClFN2O3/c29-24-3-1-2-21-23-14-31-25-12-19(33)6-9-22(25)26(23)27(35-28(21)24)18-4-7-20(8-5-18)34-11-10-32-15-17(13-30)16-32/h1-9,12,14,17,27,33H,10-11,13,15-16H2/t27-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
UniChem
US Patent
16.8n/an/an/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...


US Patent US10654866 (2020)

More data for this
Ligand-Target Pair
Estrogen receptor alpha Y537S


(Homo sapiens (Human))
BDBM443438
PNG
(US10654866, Example 5)
Show SMILES Oc1ccc2c3C(Oc4cc(F)ccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1
Show InChI InChI=1S/C28H24F2N2O3/c29-13-17-15-32(16-17)9-10-34-21-5-1-18(2-6-21)28-27-23-8-4-20(33)12-25(23)31-14-24(27)22-7-3-19(30)11-26(22)35-28/h1-8,11-12,14,17,28,33H,9-10,13,15-16H2
PDB

GoogleScholar
UniChem
US Patent
19.5n/an/an/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...


US Patent US10654866 (2020)

More data for this
Ligand-Target Pair
Estrogen receptor alpha Y537S


(Homo sapiens (Human))
BDBM443435
PNG
(US10654866, Example 3 | US10654866, Example 3A)
Show SMILES Oc1ccc2c3C(Oc4cc(Cl)ccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1
Show InChI InChI=1S/C28H24ClFN2O3/c29-19-3-7-22-24-14-31-25-12-20(33)4-8-23(25)27(24)28(35-26(22)11-19)18-1-5-21(6-2-18)34-10-9-32-15-17(13-30)16-32/h1-8,11-12,14,17,28,33H,9-10,13,15-16H2
PDB

GoogleScholar
UniChem
US Patent
27.2n/an/an/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...


US Patent US10654866 (2020)

More data for this
Ligand-Target Pair
Estrogen receptor alpha Y537S


(Homo sapiens (Human))
BDBM443447
PNG
(US10654866, Example 6A)
Show SMILES Oc1ccc2c3[C@H](Oc4c(F)cccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1
Show InChI InChI=1S/C28H24F2N2O3/c29-13-17-15-32(16-17)10-11-34-20-7-4-18(5-8-20)27-26-22-9-6-19(33)12-25(22)31-14-23(26)21-2-1-3-24(30)28(21)35-27/h1-9,12,14,17,27,33H,10-11,13,15-16H2/t27-/m1/s1
PDB

GoogleScholar
UniChem
US Patent
46n/an/an/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...


US Patent US10654866 (2020)

More data for this
Ligand-Target Pair
Estrogen receptor alpha Y537S


(Homo sapiens (Human))
BDBM443437
PNG
(US10654866, Example 4A)
Show SMILES Oc1ccc2c3[C@H](Oc4c(Cl)cccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1
Show InChI InChI=1S/C28H24ClFN2O3/c29-24-3-1-2-21-23-14-31-25-12-19(33)6-9-22(25)26(23)27(35-28(21)24)18-4-7-20(8-5-18)34-11-10-32-15-17(13-30)16-32/h1-9,12,14,17,27,33H,10-11,13,15-16H2/t27-/m1/s1
PDB

GoogleScholar
UniChem
US Patent
55n/an/an/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...


US Patent US10654866 (2020)

More data for this
Ligand-Target Pair
Estrogen receptor alpha Y537S


(Homo sapiens (Human))
BDBM443429
PNG
(US10654866, Example 1A)
Show SMILES Oc1ccc2c3[C@H](Oc4cc(ccc4-c3cnc2c1)C(F)(F)F)c1ccc(OCCN2CC(CF)C2)cc1
Show InChI InChI=1S/C29H24F4N2O3/c30-13-17-15-35(16-17)9-10-37-21-5-1-18(2-6-21)28-27-23-8-4-20(36)12-25(23)34-14-24(27)22-7-3-19(29(31,32)33)11-26(22)38-28/h1-8,11-12,14,17,28,36H,9-10,13,15-16H2/t28-/m1/s1
PDB

GoogleScholar
UniChem
US Patent
57.2n/an/an/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...


US Patent US10654866 (2020)

More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2/Estrogen receptor


(Homo sapiens (Human))
BDBM443434
PNG
(US10654866, Example 2B)
Show SMILES Oc1ccc2c3[C@@H](Oc4c(cccc4C(F)(F)F)-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1
Show InChI InChI=1S/C29H24F4N2O3/c30-13-17-15-35(16-17)10-11-37-20-7-4-18(5-8-20)27-26-22-9-6-19(36)12-25(22)34-14-23(26)21-2-1-3-24(28(21)38-27)29(31,32)33/h1-9,12,14,17,27,36H,10-11,13,15-16H2/t27-/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
UniChem
US Patent
60.4n/an/an/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...


US Patent US10654866 (2020)

More data for this
Ligand-Target Pair
Estrogen receptor alpha Y537S


(Homo sapiens (Human))
BDBM443442
PNG
(US10654866, Example 8A)
Show SMILES Cc1cccc-2c1O[C@@H](c1ccc(OCCN3CC(CF)C3)cc1)c1c-2cnc2cc(O)ccc12
Show InChI InChI=1S/C29H27FN2O3/c1-18-3-2-4-23-25-15-31-26-13-21(33)7-10-24(26)27(25)29(35-28(18)23)20-5-8-22(9-6-20)34-12-11-32-16-19(14-30)17-32/h2-10,13,15,19,29,33H,11-12,14,16-17H2,1H3/t29-/m0/s1
PDB

GoogleScholar
UniChem
US Patent
66.9n/an/an/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...


US Patent US10654866 (2020)

More data for this
Ligand-Target Pair
Estrogen receptor alpha Y537S


(Homo sapiens (Human))
BDBM443445
PNG
(US10654866, Example 5A)
Show SMILES Oc1ccc2c3[C@H](Oc4cc(F)ccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1
Show InChI InChI=1S/C28H24F2N2O3/c29-13-17-15-32(16-17)9-10-34-21-5-1-18(2-6-21)28-27-23-8-4-20(33)12-25(23)31-14-24(27)22-7-3-19(30)11-26(22)35-28/h1-8,11-12,14,17,28,33H,9-10,13,15-16H2/t28-/m1/s1
PDB

GoogleScholar
UniChem
US Patent
81.2n/an/an/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...


US Patent US10654866 (2020)

More data for this
Ligand-Target Pair
Estrogen receptor alpha Y537S


(Homo sapiens (Human))
BDBM443434
PNG
(US10654866, Example 2B)
Show SMILES Oc1ccc2c3[C@@H](Oc4c(cccc4C(F)(F)F)-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1
Show InChI InChI=1S/C29H24F4N2O3/c30-13-17-15-35(16-17)10-11-37-20-7-4-18(5-8-20)27-26-22-9-6-19(36)12-25(22)34-14-23(26)21-2-1-3-24(28(21)38-27)29(31,32)33/h1-9,12,14,17,27,36H,10-11,13,15-16H2/t27-/m0/s1
PDB

GoogleScholar
UniChem
US Patent
294n/an/an/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...


US Patent US10654866 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%