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Patent code US10660877

Compile Data Set for Download or QSAR

Found 2542 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Toll-like receptor 7


(Homo sapiens (Human))
BDBM443583
PNG
(US10660877, Example 166)
Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCN(CC1)C(=O)CNC(C)=O)-c1cc(C)nc(C)c1
Show InChI InChI=1S/C27H34N4O2/c1-16(2)26-23-14-21(20-8-10-31(11-9-20)25(33)15-28-19(5)32)6-7-24(23)30-27(26)22-12-17(3)29-18(4)13-22/h6-7,12-14,16,20,30H,8-11,15H2,1-5H3,(H,28,32)
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Bristol-Myers Squibb Company

US Patent


Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...


US Patent US10660877 (2020)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM443500
PNG
(US10660877, Example 77)
Show SMILES CC(C)c1c([nH]c2ccc(C3CCNCC3)c(F)c12)-c1cc(C)nc(C)c1
Show InChI InChI=1S/C23H28FN3/c1-13(2)20-21-19(27-23(20)17-11-14(3)26-15(4)12-17)6-5-18(22(21)24)16-7-9-25-10-8-16/h5-6,11-13,16,25,27H,7-10H2,1-4H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...


US Patent US10660877 (2020)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM443999
PNG
(US10660877, Example 588)
Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCN(CC1)C(=O)CN(C)C)-c1cc(C)nc(C)c1F
Show InChI InChI=1S/C27H35FN4O/c1-16(2)25-21-14-20(19-9-11-32(12-10-19)24(33)15-31(5)6)7-8-23(21)30-27(25)22-13-17(3)29-18(4)26(22)28/h7-8,13-14,16,19,30H,9-12,15H2,1-6H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...


US Patent US10660877 (2020)

More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM444094
PNG
(US10660877, Example 683)
Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCN(CC2=C[N](C)=NN2)CC1)-c1cc(C)ncc1C
Show InChI InChI=1S/C27H35N6/c1-17(2)26-24-13-21(20-8-10-33(11-9-20)16-22-15-32(5)31-30-22)6-7-25(24)29-27(26)23-12-19(4)28-14-18(23)3/h6-7,12-15,17,20,29H,8-11,16H2,1-5H3,(H,30,31)
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Bristol-Myers Squibb Company

US Patent


Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...


US Patent US10660877 (2020)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM444082
PNG
(US10660877, Example 671)
Show SMILES CCN(CC)CCCN1CCC(CC1)c1ccc2[nH]c(c(C(C)C)c2c1)-c1cc(C)nc(C)c1
Show InChI InChI=1S/C30H44N4/c1-7-33(8-2)14-9-15-34-16-12-24(13-17-34)25-10-11-28-27(20-25)29(21(3)4)30(32-28)26-18-22(5)31-23(6)19-26/h10-11,18-21,24,32H,7-9,12-17H2,1-6H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...


US Patent US10660877 (2020)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM443799
PNG
(US10660877, Example 387)
Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCN(CC1)C(=O)CNC1CCOC1)-c1cc(C)nc(C)c1
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Bristol-Myers Squibb Company

US Patent


Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...


US Patent US10660877 (2020)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM443512
PNG
(US10660877, Example 92)
Show SMILES CC(c1c([nH]c2ccc(cc12)C1CCNCC1)-c1cc(C)nc(C)c1)C(F)(F)F
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Bristol-Myers Squibb Company

US Patent


Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...


US Patent US10660877 (2020)

More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM444092
PNG
(US10660877, Example 681)
Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCN(Cc2ccn[nH]2)CC1)-c1cc(C)ncc1C
Show InChI InChI=1S/C27H33N5/c1-17(2)26-24-14-21(20-8-11-32(12-9-20)16-22-7-10-29-31-22)5-6-25(24)30-27(26)23-13-19(4)28-15-18(23)3/h5-7,10,13-15,17,20,30H,8-9,11-12,16H2,1-4H3,(H,29,31)
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Bristol-Myers Squibb Company

US Patent


Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...


US Patent US10660877 (2020)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM443610
PNG
(US10660877, Example 194)
Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCN(CC1)C(=O)C(C)(C)N)-c1cc(C)nc(C)c1
Show InChI InChI=1S/C27H36N4O/c1-16(2)24-22-15-20(19-9-11-31(12-10-19)26(32)27(5,6)28)7-8-23(22)30-25(24)21-13-17(3)29-18(4)14-21/h7-8,13-16,19,30H,9-12,28H2,1-6H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...


US Patent US10660877 (2020)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM21958
PNG
(2-(2,6-dimethylpyridin-4-yl)-3-isopropyl-5-(piperi...)
Show SMILES N[C@@H](CCCN=C(N)N[N+]([O-])=O)C(O)=O
Show InChI InChI=1S/C6H13N5O4/c7-4(5(12)13)2-1-3-9-6(8)10-11(14)15/h4H,1-3,7H2,(H,12,13)(H3,8,9,10)/t4-/m0/s1
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Similars

US Patent
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Bristol-Myers Squibb Company

US Patent


Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...


US Patent US10660877 (2020)

More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM444261
PNG
(US10660877, Example 851)
Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCN(CC(C)(C)O)CC1)-c1cc(C)ncc1C
Show InChI InChI=1S/C27H37N3O/c1-17(2)25-23-14-21(20-9-11-30(12-10-20)16-27(5,6)31)7-8-24(23)29-26(25)22-13-19(4)28-15-18(22)3/h7-8,13-15,17,20,29,31H,9-12,16H2,1-6H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...


US Patent US10660877 (2020)

More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM443857
PNG
(US10660877, Example 445)
Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCN(Cc2ccn(C)n2)CC1)-c1cc(C)nc(C)c1
Show InChI InChI=1S/C28H35N5/c1-18(2)27-25-16-22(21-8-12-33(13-9-21)17-24-10-11-32(5)31-24)6-7-26(25)30-28(27)23-14-19(3)29-20(4)15-23/h6-7,10-11,14-16,18,21,30H,8-9,12-13,17H2,1-5H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...


US Patent US10660877 (2020)

More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM444100
PNG
(US10660877, Example 689)
Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCN(Cc2ccn(C)n2)CC1)-c1cc(C)ncc1C
Show InChI InChI=1S/C28H35N5/c1-18(2)27-25-15-22(21-8-12-33(13-9-21)17-23-10-11-32(5)31-23)6-7-26(25)30-28(27)24-14-20(4)29-16-19(24)3/h6-7,10-11,14-16,18,21,30H,8-9,12-13,17H2,1-5H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...


US Patent US10660877 (2020)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM443745
PNG
(US10660877, Example 333)
Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCN(CC2COC2)CC1)-c1cc(C)nc(C)c1
Show InChI InChI=1S/C27H35N3O/c1-17(2)26-24-13-22(21-7-9-30(10-8-21)14-20-15-31-16-20)5-6-25(24)29-27(26)23-11-18(3)28-19(4)12-23/h5-6,11-13,17,20-21,29H,7-10,14-16H2,1-4H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...


US Patent US10660877 (2020)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM443501
PNG
(US10660877, Example 78)
Show SMILES CC(C)c1c([nH]c2cc(F)c(cc12)C1CCNCC1)-c1cc(C)nc(C)c1
Show InChI InChI=1S/C23H28FN3/c1-13(2)22-19-11-18(16-5-7-25-8-6-16)20(24)12-21(19)27-23(22)17-9-14(3)26-15(4)10-17/h9-13,16,25,27H,5-8H2,1-4H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...


US Patent US10660877 (2020)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM444085
PNG
(US10660877, Example 674)
Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCN(CCCN(C)C)CC1)-c1cc(C)nc(C)c1
Show InChI InChI=1S/C28H40N4/c1-19(2)27-25-18-23(22-10-14-32(15-11-22)13-7-12-31(5)6)8-9-26(25)30-28(27)24-16-20(3)29-21(4)17-24/h8-9,16-19,22,30H,7,10-15H2,1-6H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...


US Patent US10660877 (2020)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM443580
PNG
(US10660877, Example 163)
Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCN(CC1)C(=O)CN1CCN(C)CC1)-c1cc(C)nc(C)c1
Show InChI InChI=1S/C30H41N5O/c1-20(2)29-26-18-24(6-7-27(26)32-30(29)25-16-21(3)31-22(4)17-25)23-8-10-35(11-9-23)28(36)19-34-14-12-33(5)13-15-34/h6-7,16-18,20,23,32H,8-15,19H2,1-5H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...


US Patent US10660877 (2020)

More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM444103
PNG
(US10660877, Example 692)
Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCN(Cc2ccn(C)n2)CC1)-c1cc(C)ncc1F
Show InChI InChI=1S/C27H32FN5/c1-17(2)26-23-14-20(19-7-11-33(12-8-19)16-21-9-10-32(4)31-21)5-6-25(23)30-27(26)22-13-18(3)29-15-24(22)28/h5-6,9-10,13-15,17,19,30H,7-8,11-12,16H2,1-4H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...


US Patent US10660877 (2020)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM443599
PNG
(US10660877, Example 183 | US10660877, Example 570)
Show SMILES CNCCC(=O)N1CCC(CC1)c1ccc2[nH]c(c(C(C)C)c2c1)-c1ccnc(C)c1
Show InChI InChI=1S/C26H34N4O/c1-17(2)25-22-16-20(19-9-13-30(14-10-19)24(31)8-11-27-4)5-6-23(22)29-26(25)21-7-12-28-18(3)15-21/h5-7,12,15-17,19,27,29H,8-11,13-14H2,1-4H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...


US Patent US10660877 (2020)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM443452
PNG
(US10660877, Example 51)
Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCNCC1)-c1cc(C)nc(C)c1F
Show InChI InChI=1S/C23H28FN3/c1-13(2)21-18-12-17(16-7-9-25-10-8-16)5-6-20(18)27-23(21)19-11-14(3)26-15(4)22(19)24/h5-6,11-13,16,25,27H,7-10H2,1-4H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...


US Patent US10660877 (2020)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM444264
PNG
(US10660877, Example 854)
Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCN(CC(O)CO)CC1)-c1cc(C)nc(C)c1
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Bristol-Myers Squibb Company

US Patent


Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...


US Patent US10660877 (2020)

More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM442004
PNG
(US10660877, Example 31)
Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCNCC1)-c1cc(C)ncc1C
Show InChI InChI=1S/C23H29N3/c1-14(2)22-20-12-18(17-7-9-24-10-8-17)5-6-21(20)26-23(22)19-11-16(4)25-13-15(19)3/h5-6,11-14,17,24,26H,7-10H2,1-4H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...


US Patent US10660877 (2020)

More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM444047
PNG
(US10660877, Example 636)
Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCN(C)CC1)-c1cc(C)ncc1C
Show InChI InChI=1S/C24H31N3/c1-15(2)23-21-13-19(18-8-10-27(5)11-9-18)6-7-22(21)26-24(23)20-12-17(4)25-14-16(20)3/h6-7,12-15,18,26H,8-11H2,1-5H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...


US Patent US10660877 (2020)

More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM444263
PNG
(US10660877, Example 853)
Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCN(CC(C)(O)C=C)CC1)-c1cc(C)nc(C)c1
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Bristol-Myers Squibb Company

US Patent


Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...


US Patent US10660877 (2020)

More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM444137
PNG
(US10660877, Example 726)
Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCN(CC1)C1CCCOC1)-c1cc(C)ncc1C
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Bristol-Myers Squibb Company

US Patent


Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...


US Patent US10660877 (2020)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM443627
PNG
(US10660877, Example 211)
Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCN(CC(=O)NC2CCC(O)CC2)CC1)-c1cc(C)nc(C)c1
Show InChI InChI=1S/C31H42N4O2/c1-19(2)30-27-17-23(5-10-28(27)34-31(30)24-15-20(3)32-21(4)16-24)22-11-13-35(14-12-22)18-29(37)33-25-6-8-26(36)9-7-25/h5,10,15-17,19,22,25-26,34,36H,6-9,11-14,18H2,1-4H3,(H,33,37)
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Bristol-Myers Squibb Company

US Patent


Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...


US Patent US10660877 (2020)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM443901
PNG
(US10660877, Example 489-A)
Show SMILES CC(C)c1c([nH]c2ccc(cc12)[C@H]1CCNCC1(F)F)-c1cc(C)nc(C)c1
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Bristol-Myers Squibb Company

US Patent


Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...


US Patent US10660877 (2020)

More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM444139
PNG
(US10660877, Example 728)
Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCN(CC1)C1CCOC1)-c1cc(C)ncc1C
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Bristol-Myers Squibb Company

US Patent


Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...


US Patent US10660877 (2020)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM444033
PNG
(US10660877, Example 622)
Show SMILES CNCC(=O)N1CCC(CC1)c1ccc2[nH]c(c(C(C)C)c2c1)-c1cc(C)nc(C)c1F
Show InChI InChI=1S/C26H33FN4O/c1-15(2)24-20-13-19(18-8-10-31(11-9-18)23(32)14-28-5)6-7-22(20)30-26(24)21-12-16(3)29-17(4)25(21)27/h6-7,12-13,15,18,28,30H,8-11,14H2,1-5H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...


US Patent US10660877 (2020)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM443686
PNG
(US10660877, Example 272)
Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCN(CC(=O)N2CCNC(=O)C2)CC1)-c1cc(C)nc(C)c1
Show InChI InChI=1S/C29H37N5O2/c1-18(2)28-24-15-22(5-6-25(24)32-29(28)23-13-19(3)31-20(4)14-23)21-7-10-33(11-8-21)17-27(36)34-12-9-30-26(35)16-34/h5-6,13-15,18,21,32H,7-12,16-17H2,1-4H3,(H,30,35)
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Bristol-Myers Squibb Company

US Patent


Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...


US Patent US10660877 (2020)

More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM443454
PNG
(US10660877, Example 53)
Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCNCC1)-c1ccnc(C)c1F
Show InChI InChI=1S/C22H26FN3/c1-13(2)20-18-12-16(15-6-9-24-10-7-15)4-5-19(18)26-22(20)17-8-11-25-14(3)21(17)23/h4-5,8,11-13,15,24,26H,6-7,9-10H2,1-3H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...


US Patent US10660877 (2020)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM444238
PNG
(US10660877, Example 828)
Show SMILES CC(C)c1c([nH]c2cc(F)c(cc12)C1CCN(C)CC1)-c1cc(C)nc(C)c1
Show InChI InChI=1S/C24H30FN3/c1-14(2)23-20-12-19(17-6-8-28(5)9-7-17)21(25)13-22(20)27-24(23)18-10-15(3)26-16(4)11-18/h10-14,17,27H,6-9H2,1-5H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...


US Patent US10660877 (2020)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM443695
PNG
(US10660877, Example 281)
Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCN(CC(=O)N2CCS(=O)(=O)CC2)CC1)-c1cc(C)nc(C)c1
Show InChI InChI=1S/C29H38N4O3S/c1-19(2)28-25-17-23(5-6-26(25)31-29(28)24-15-20(3)30-21(4)16-24)22-7-9-32(10-8-22)18-27(34)33-11-13-37(35,36)14-12-33/h5-6,15-17,19,22,31H,7-14,18H2,1-4H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...


US Patent US10660877 (2020)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM443612
PNG
(US10660877, Example 196)
Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCN(CC1)C(=O)[C@@H]1C[C@H](F)CN1)-c1cc(C)nc(C)c1
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Bristol-Myers Squibb Company

US Patent


Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...


US Patent US10660877 (2020)

More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM444233
PNG
(US10660877, Example 823 | US10660877, Example 824)
Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCN(Cc2cnc[nH]2)CC1)-c1cc(C)ncc1N
Show InChI InChI=1S/C26H32N6/c1-16(2)25-22-11-19(18-6-8-32(9-7-18)14-20-12-28-15-30-20)4-5-24(22)31-26(25)21-10-17(3)29-13-23(21)27/h4-5,10-13,15-16,18,31H,6-9,14,27H2,1-3H3,(H,28,30)
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Bristol-Myers Squibb Company

US Patent


Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...


US Patent US10660877 (2020)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM443850
PNG
(US10660877, Example 438)
Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCN(Cc2cn[nH]c2)CC1)-c1cc(C)nc(C)c1
Show InChI InChI=1S/C27H33N5/c1-17(2)26-24-13-22(21-7-9-32(10-8-21)16-20-14-28-29-15-20)5-6-25(24)31-27(26)23-11-18(3)30-19(4)12-23/h5-6,11-15,17,21,31H,7-10,16H2,1-4H3,(H,28,29)
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Bristol-Myers Squibb Company

US Patent


Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...


US Patent US10660877 (2020)

More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM443503
PNG
(US10660877, Example 80)
Show SMILES CC(C)c1c([nH]c2cc(F)c(cc12)C1CCNCC1)-c1cc(C)ncc1C
Show InChI InChI=1S/C23H28FN3/c1-13(2)22-19-10-18(16-5-7-25-8-6-16)20(24)11-21(19)27-23(22)17-9-15(4)26-12-14(17)3/h9-13,16,25,27H,5-8H2,1-4H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...


US Patent US10660877 (2020)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM444290
PNG
(US10660877, Example 182)
Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCN(CC1)C(=O)[C@H]1CCNC1)-c1cc(C)nc(C)c1
Show InChI InChI=1S/C28H36N4O/c1-17(2)26-24-15-21(20-8-11-32(12-9-20)28(33)22-7-10-29-16-22)5-6-25(24)31-27(26)23-13-18(3)30-19(4)14-23/h5-6,13-15,17,20,22,29,31H,7-12,16H2,1-4H3/t22-/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...


US Patent US10660877 (2020)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM444292
PNG
(US10660877, Example 489-B)
Show SMILES CC(C)c1c([nH]c2ccc(cc12)[C@@H]1CCNCC1(F)F)-c1cc(C)nc(C)c1
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Bristol-Myers Squibb Company

US Patent


Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...


US Patent US10660877 (2020)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM444066
PNG
(US10660877, Example 655)
Show SMILES CNC(=O)CN1CCC(CC1)c1ccc2[nH]c(c(C(C)C)c2c1)-c1cc(C)nc(C)c1F
Show InChI InChI=1S/C26H33FN4O/c1-15(2)24-20-13-19(18-8-10-31(11-9-18)14-23(32)28-5)6-7-22(20)30-26(24)21-12-16(3)29-17(4)25(21)27/h6-7,12-13,15,18,30H,8-11,14H2,1-5H3,(H,28,32)
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Bristol-Myers Squibb Company

US Patent


Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...


US Patent US10660877 (2020)

More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM443999
PNG
(US10660877, Example 588)
Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCN(CC1)C(=O)CN(C)C)-c1cc(C)nc(C)c1F
Show InChI InChI=1S/C27H35FN4O/c1-16(2)25-21-14-20(19-9-11-32(12-10-19)24(33)15-31(5)6)7-8-23(21)30-27(25)22-13-17(3)29-18(4)26(22)28/h7-8,13-14,16,19,30H,9-12,15H2,1-6H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...


US Patent US10660877 (2020)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM443803
PNG
(US10660877, Example 391)
Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCN(CC1)C(=O)CN1CC[C@@H](O)C1)-c1cc(C)nc(C)c1
Show InChI InChI=1S/C29H38N4O2/c1-18(2)28-25-15-22(5-6-26(25)31-29(28)23-13-19(3)30-20(4)14-23)21-7-11-33(12-8-21)27(35)17-32-10-9-24(34)16-32/h5-6,13-15,18,21,24,31,34H,7-12,16-17H2,1-4H3/t24-/m1/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...


US Patent US10660877 (2020)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM443858
PNG
(US10660877, Example 446)
Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCN(Cc2c[nH]nn2)CC1)-c1cc(C)nc(C)c1
Show InChI InChI=1S/C26H32N6/c1-16(2)25-23-13-20(19-7-9-32(10-8-19)15-22-14-27-31-30-22)5-6-24(23)29-26(25)21-11-17(3)28-18(4)12-21/h5-6,11-14,16,19,29H,7-10,15H2,1-4H3,(H,27,30,31)
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Bristol-Myers Squibb Company

US Patent


Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...


US Patent US10660877 (2020)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM443516
PNG
(3-(dimethylamino)-1-(4-(2-(2,6-dimethylpyridin-4-y...)
Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCN(CC1)C(=O)CCN(C)C)-c1cc(C)nc(C)c1
Show InChI InChI=1S/C28H38N4O/c1-18(2)27-24-17-22(21-9-13-32(14-10-21)26(33)11-12-31(5)6)7-8-25(24)30-28(27)23-15-19(3)29-20(4)16-23/h7-8,15-18,21,30H,9-14H2,1-6H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...


US Patent US10660877 (2020)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM444267
PNG
(US10660877, Example 857)
Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCN(CC1)C(=O)C(=O)N1CCNCC1)-c1cc(C)nc(C)c1
Show InChI InChI=1S/C29H37N5O2/c1-18(2)26-24-17-22(5-6-25(24)32-27(26)23-15-19(3)31-20(4)16-23)21-7-11-33(12-8-21)28(35)29(36)34-13-9-30-10-14-34/h5-6,15-18,21,30,32H,7-14H2,1-4H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...


US Patent US10660877 (2020)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM443499
PNG
(US10660877, Example 76)
Show SMILES CC(C)c1c([nH]c2ccc(C3CCNCC3)c(F)c12)-c1ccnc(C)c1
Show InChI InChI=1S/C22H26FN3/c1-13(2)19-20-18(26-22(19)16-8-11-25-14(3)12-16)5-4-17(21(20)23)15-6-9-24-10-7-15/h4-5,8,11-13,15,24,26H,6-7,9-10H2,1-3H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...


US Patent US10660877 (2020)

More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM441986
PNG
(US10660877, Example 16)
Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCNCC1)-c1cc(C)ncc1F
Show InChI InChI=1S/C22H26FN3/c1-13(2)21-18-11-16(15-6-8-24-9-7-15)4-5-20(18)26-22(21)17-10-14(3)25-12-19(17)23/h4-5,10-13,15,24,26H,6-9H2,1-3H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...


US Patent US10660877 (2020)

More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM443745
PNG
(US10660877, Example 333)
Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCN(CC2COC2)CC1)-c1cc(C)nc(C)c1
Show InChI InChI=1S/C27H35N3O/c1-17(2)26-24-13-22(21-7-9-30(10-8-21)14-20-15-31-16-20)5-6-25(24)29-27(26)23-11-18(3)28-19(4)12-23/h5-6,11-13,17,20-21,29H,7-10,14-16H2,1-4H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...


US Patent US10660877 (2020)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM443726
PNG
(US10660877, Example 314)
Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCN(CCC(N)=O)CC1)-c1cc(C)nc(C)c1
Show InChI InChI=1S/C26H34N4O/c1-16(2)25-22-15-20(19-7-10-30(11-8-19)12-9-24(27)31)5-6-23(22)29-26(25)21-13-17(3)28-18(4)14-21/h5-6,13-16,19,29H,7-12H2,1-4H3,(H2,27,31)
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Bristol-Myers Squibb Company

US Patent


Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...


US Patent US10660877 (2020)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM443735
PNG
(US10660877, Example 323)
Show SMILES CCCN1CCC(CC1)c1ccc2[nH]c(c(C(C)C)c2c1)-c1cc(C)nc(C)c1
Show InChI InChI=1S/C26H35N3/c1-6-11-29-12-9-20(10-13-29)21-7-8-24-23(16-21)25(17(2)3)26(28-24)22-14-18(4)27-19(5)15-22/h7-8,14-17,20,28H,6,9-13H2,1-5H3
PDB

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Bristol-Myers Squibb Company

US Patent


Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...


US Patent US10660877 (2020)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%