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Patent code US10660898

Compile Data Set for Download or QSAR
Found 27 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta


(Homo sapiens (Human))
BDBM444320
PNG
(US10660898, Example 70)
Show SMILES Cc1c(Cn2c(nc3c(cc(cc23)N2CCOCC2)C(O)=O)C(F)F)cccc1C(F)(F)F
Show InChI InChI=1S/C22H20F5N3O3/c1-12-13(3-2-4-16(12)22(25,26)27)11-30-17-10-14(29-5-7-33-8-6-29)9-15(21(31)32)18(17)28-20(30)19(23)24/h2-4,9-10,19H,5-8,11H2,1H3,(H,31,32)
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GLAXOSMITHKLINE LLC

US Patent


Assay Description
PI3Kinase Reaction Buffer was prepared by diluting the stock 1:4 with de-ionized water. Freshly prepared DTT was added at a final concentration of 5 ...


US Patent US10660898 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta


(Homo sapiens (Human))
BDBM444306
PNG
(US10660898, Example 25)
Show SMILES Cc1nc2c(cc(cc2n1Cc1cccc2ccccc12)N1CCOCC1)-c1nnc[nH]1
Show InChI InChI=1S/C25H24N6O/c1-17-28-24-22(25-26-16-27-29-25)13-20(30-9-11-32-12-10-30)14-23(24)31(17)15-19-7-4-6-18-5-2-3-8-21(18)19/h2-8,13-14,16H,9-12,15H2,1H3,(H,26,27,29)
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GLAXOSMITHKLINE LLC

US Patent


Assay Description
PI3Kinase Reaction Buffer was prepared by diluting the stock 1:4 with de-ionized water. Freshly prepared DTT was added at a final concentration of 5 ...


US Patent US10660898 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta


(Homo sapiens (Human))
BDBM444315
PNG
(US10660898, Example 53)
Show SMILES Cc1c(Cl)cccc1Cn1c(nc2c(cc(cc12)N1CCOCC1)C(O)=O)C(F)(F)F
Show InChI InChI=1S/C21H19ClF3N3O3/c1-12-13(3-2-4-16(12)22)11-28-17-10-14(27-5-7-31-8-6-27)9-15(19(29)30)18(17)26-20(28)21(23,24)25/h2-4,9-10H,5-8,11H2,1H3,(H,29,30)
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GLAXOSMITHKLINE LLC

US Patent


Assay Description
PI3Kinase Reaction Buffer was prepared by diluting the stock 1:4 with de-ionized water. Freshly prepared DTT was added at a final concentration of 5 ...


US Patent US10660898 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta


(Homo sapiens (Human))
BDBM444311
PNG
(US10660898, Example 39)
Show SMILES Cc1nc2c(cc(cc2n1Cc1cccc(c1C)C(F)(F)F)N1CCOCC1)-c1nnc[nH]1
Show InChI InChI=1S/C23H23F3N6O/c1-14-16(4-3-5-19(14)23(24,25)26)12-32-15(2)29-21-18(22-27-13-28-30-22)10-17(11-20(21)32)31-6-8-33-9-7-31/h3-5,10-11,13H,6-9,12H2,1-2H3,(H,27,28,30)
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GLAXOSMITHKLINE LLC

US Patent


Assay Description
PI3Kinase Reaction Buffer was prepared by diluting the stock 1:4 with de-ionized water. Freshly prepared DTT was added at a final concentration of 5 ...


US Patent US10660898 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta


(Homo sapiens (Human))
BDBM444319
PNG
(US10660898, Example 63)
Show SMILES Cc1nc2c(Br)cc(cc2n1Cc1cccc(c1C)C(F)(F)F)N1CCOCC1
Show InChI InChI=1S/C21H21BrF3N3O/c1-13-15(4-3-5-17(13)21(23,24)25)12-28-14(2)26-20-18(22)10-16(11-19(20)28)27-6-8-29-9-7-27/h3-5,10-11H,6-9,12H2,1-2H3
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GLAXOSMITHKLINE LLC

US Patent


Assay Description
PI3Kinase Reaction Buffer was prepared by diluting the stock 1:4 with de-ionized water. Freshly prepared DTT was added at a final concentration of 5 ...


US Patent US10660898 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta


(Homo sapiens (Human))
BDBM444301
PNG
(US10660898, Example 15)
Show SMILES Cc1nc2c(F)cc(cc2n1Cc1cccc2ccccc12)N1CCOCC1
Show InChI InChI=1S/C23H22FN3O/c1-16-25-23-21(24)13-19(26-9-11-28-12-10-26)14-22(23)27(16)15-18-7-4-6-17-5-2-3-8-20(17)18/h2-8,13-14H,9-12,15H2,1H3
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GLAXOSMITHKLINE LLC

US Patent


Assay Description
PI3Kinase Reaction Buffer was prepared by diluting the stock 1:4 with de-ionized water. Freshly prepared DTT was added at a final concentration of 5 ...


US Patent US10660898 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta


(Homo sapiens (Human))
BDBM444314
PNG
(US10660898, Example 50)
Show SMILES OC(=O)c1cc(cc2n(Cc3cccc4ccccc34)c(nc12)C(F)(F)F)N1CCOCC1
Show InChI InChI=1S/C24H20F3N3O3/c25-24(26,27)23-28-21-19(22(31)32)12-17(29-8-10-33-11-9-29)13-20(21)30(23)14-16-6-3-5-15-4-1-2-7-18(15)16/h1-7,12-13H,8-11,14H2,(H,31,32)
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GLAXOSMITHKLINE LLC

US Patent


Assay Description
PI3Kinase Reaction Buffer was prepared by diluting the stock 1:4 with de-ionized water. Freshly prepared DTT was added at a final concentration of 5 ...


US Patent US10660898 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta


(Homo sapiens (Human))
BDBM444297
PNG
(US10660898, Example 5)
Show SMILES Cc1nc2c(O)cc(cc2n1Cc1cccc2ccccc12)N1CCOCC1
Show InChI InChI=1S/C23H23N3O2/c1-16-24-23-21(13-19(14-22(23)27)25-9-11-28-12-10-25)26(16)15-18-7-4-6-17-5-2-3-8-20(17)18/h2-8,13-14,27H,9-12,15H2,1H3
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GLAXOSMITHKLINE LLC

US Patent


Assay Description
PI3Kinase Reaction Buffer was prepared by diluting the stock 1:4 with de-ionized water. Freshly prepared DTT was added at a final concentration of 5 ...


US Patent US10660898 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta


(Homo sapiens (Human))
BDBM444312
PNG
(US10660898, Example 41)
Show SMILES CC(=O)c1cc(cc2n(Cc3cccc4ccccc34)c(C)nc12)N1CCOCC1
Show InChI InChI=1S/C25H25N3O2/c1-17(29)23-14-21(27-10-12-30-13-11-27)15-24-25(23)26-18(2)28(24)16-20-8-5-7-19-6-3-4-9-22(19)20/h3-9,14-15H,10-13,16H2,1-2H3
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GLAXOSMITHKLINE LLC

US Patent


Assay Description
PI3Kinase Reaction Buffer was prepared by diluting the stock 1:4 with de-ionized water. Freshly prepared DTT was added at a final concentration of 5 ...


US Patent US10660898 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta


(Homo sapiens (Human))
BDBM444321
PNG
(US10660898, Example 72)
Show SMILES Cc1c(Cl)cccc1Cn1c(nc2c(cc(cc12)N1CCOCC1)C(O)=O)C(F)F
Show InChI InChI=1S/C21H20ClF2N3O3/c1-12-13(3-2-4-16(12)22)11-27-17-10-14(26-5-7-30-8-6-26)9-15(21(28)29)18(17)25-20(27)19(23)24/h2-4,9-10,19H,5-8,11H2,1H3,(H,28,29)
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GLAXOSMITHKLINE LLC

US Patent


Assay Description
PI3Kinase Reaction Buffer was prepared by diluting the stock 1:4 with de-ionized water. Freshly prepared DTT was added at a final concentration of 5 ...


US Patent US10660898 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta


(Homo sapiens (Human))
BDBM444298
PNG
(US10660898, Example 11)
Show SMILES CC(C)c1nc2c(O)cc(cc2n1Cc1cccc2ccccc12)N1CCOCC1
Show InChI InChI=1S/C25H27N3O2/c1-17(2)25-26-24-22(14-20(15-23(24)29)27-10-12-30-13-11-27)28(25)16-19-8-5-7-18-6-3-4-9-21(18)19/h3-9,14-15,17,29H,10-13,16H2,1-2H3
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GLAXOSMITHKLINE LLC

US Patent


Assay Description
PI3Kinase Reaction Buffer was prepared by diluting the stock 1:4 with de-ionized water. Freshly prepared DTT was added at a final concentration of 5 ...


US Patent US10660898 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta


(Homo sapiens (Human))
BDBM444316
PNG
(US10660898, Example 54)
Show SMILES Cc1c(Cn2c(nc3c(cc(cc23)N2CCOCC2)C(N)=O)C(F)(F)F)cccc1C(F)(F)F
Show InChI InChI=1S/C22H20F6N4O2/c1-12-13(3-2-4-16(12)21(23,24)25)11-32-17-10-14(31-5-7-34-8-6-31)9-15(19(29)33)18(17)30-20(32)22(26,27)28/h2-4,9-10H,5-8,11H2,1H3,(H2,29,33)
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GLAXOSMITHKLINE LLC

US Patent


Assay Description
PI3Kinase Reaction Buffer was prepared by diluting the stock 1:4 with de-ionized water. Freshly prepared DTT was added at a final concentration of 5 ...


US Patent US10660898 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta


(Homo sapiens (Human))
BDBM444302
PNG
(US10660898, Example 17)
Show SMILES CCc1nc2c(F)cc(cc2n1Cc1cccc2ccccc12)N1CCOCC1
Show InChI InChI=1S/C24H24FN3O/c1-2-23-26-24-21(25)14-19(27-10-12-29-13-11-27)15-22(24)28(23)16-18-8-5-7-17-6-3-4-9-20(17)18/h3-9,14-15H,2,10-13,16H2,1H3
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GLAXOSMITHKLINE LLC

US Patent


Assay Description
PI3Kinase Reaction Buffer was prepared by diluting the stock 1:4 with de-ionized water. Freshly prepared DTT was added at a final concentration of 5 ...


US Patent US10660898 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta


(Homo sapiens (Human))
BDBM444300
PNG
(US10660898, Example 14)
Show SMILES CCc1nc2c(O)cc(cc2n1Cc1cccc(Cl)c1Cl)N1CCOCC1
Show InChI InChI=1S/C20H21Cl2N3O2/c1-2-18-23-20-16(25(18)12-13-4-3-5-15(21)19(13)22)10-14(11-17(20)26)24-6-8-27-9-7-24/h3-5,10-11,26H,2,6-9,12H2,1H3
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GLAXOSMITHKLINE LLC

US Patent


Assay Description
PI3Kinase Reaction Buffer was prepared by diluting the stock 1:4 with de-ionized water. Freshly prepared DTT was added at a final concentration of 5 ...


US Patent US10660898 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta


(Homo sapiens (Human))
BDBM444313
PNG
(US10660898, Example 43)
Show SMILES Cc1nc2c(CO)cc(cc2n1Cc1cccc(c1C)C(F)(F)F)N1CCOCC1
Show InChI InChI=1S/C22H24F3N3O2/c1-14-16(4-3-5-19(14)22(23,24)25)12-28-15(2)26-21-17(13-29)10-18(11-20(21)28)27-6-8-30-9-7-27/h3-5,10-11,29H,6-9,12-13H2,1-2H3
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GLAXOSMITHKLINE LLC

US Patent


Assay Description
PI3Kinase Reaction Buffer was prepared by diluting the stock 1:4 with de-ionized water. Freshly prepared DTT was added at a final concentration of 5 ...


US Patent US10660898 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta


(Homo sapiens (Human))
BDBM50059637
PNG
(GSK-2636771 | GSK2636771 | US10660898, Example 31)
Show SMILES Cc1nc2c(cc(cc2n1Cc1cccc(c1C)C(F)(F)F)N1CCOCC1)C(O)=O
Show InChI InChI=1S/C22H22F3N3O3/c1-13-15(4-3-5-18(13)22(23,24)25)12-28-14(2)26-20-17(21(29)30)10-16(11-19(20)28)27-6-8-31-9-7-27/h3-5,10-11H,6-9,12H2,1-2H3,(H,29,30)
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GLAXOSMITHKLINE LLC

US Patent


Assay Description
PI3Kinase Reaction Buffer was prepared by diluting the stock 1:4 with de-ionized water. Freshly prepared DTT was added at a final concentration of 5 ...


US Patent US10660898 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta


(Homo sapiens (Human))
BDBM444304
PNG
(US10660898, Example 20)
Show SMILES Cc1nc2c(cc(cc2n1Cc1cccc2ccccc12)N1CCOCC1)C(O)=O
Show InChI InChI=1S/C24H23N3O3/c1-16-25-23-21(24(28)29)13-19(26-9-11-30-12-10-26)14-22(23)27(16)15-18-7-4-6-17-5-2-3-8-20(17)18/h2-8,13-14H,9-12,15H2,1H3,(H,28,29)
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GLAXOSMITHKLINE LLC

US Patent


Assay Description
PI3Kinase Reaction Buffer was prepared by diluting the stock 1:4 with de-ionized water. Freshly prepared DTT was added at a final concentration of 5 ...


US Patent US10660898 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta


(Homo sapiens (Human))
BDBM444318
PNG
(US10660898, Example 59)
Show SMILES Cc1nc2c(cc(cc2n1Cc1cccc(Cl)c1C)N1CCOCC1)C(O)=O
Show InChI InChI=1S/C21H22ClN3O3/c1-13-15(4-3-5-18(13)22)12-25-14(2)23-20-17(21(26)27)10-16(11-19(20)25)24-6-8-28-9-7-24/h3-5,10-11H,6-9,12H2,1-2H3,(H,26,27)
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GLAXOSMITHKLINE LLC

US Patent


Assay Description
PI3Kinase Reaction Buffer was prepared by diluting the stock 1:4 with de-ionized water. Freshly prepared DTT was added at a final concentration of 5 ...


US Patent US10660898 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta


(Homo sapiens (Human))
BDBM444317
PNG
(US10660898, Example 58)
Show SMILES Cc1nc2c(cc(cc2n1Cc1cccc2ccccc12)N1CCOCC1)-c1nnn[nH]1
Show InChI InChI=1S/C24H23N7O/c1-16-25-23-21(24-26-28-29-27-24)13-19(30-9-11-32-12-10-30)14-22(23)31(16)15-18-7-4-6-17-5-2-3-8-20(17)18/h2-8,13-14H,9-12,15H2,1H3,(H,26,27,28,29)
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GLAXOSMITHKLINE LLC

US Patent


Assay Description
PI3Kinase Reaction Buffer was prepared by diluting the stock 1:4 with de-ionized water. Freshly prepared DTT was added at a final concentration of 5 ...


US Patent US10660898 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta


(Homo sapiens (Human))
BDBM444299
PNG
(US10660898, Example 13)
Show SMILES CC(C)c1nc2c(O)cc(cc2n1Cc1cccc(Cl)c1Cl)N1CCOCC1
Show InChI InChI=1S/C21H23Cl2N3O2/c1-13(2)21-24-20-17(26(21)12-14-4-3-5-16(22)19(14)23)10-15(11-18(20)27)25-6-8-28-9-7-25/h3-5,10-11,13,27H,6-9,12H2,1-2H3
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GLAXOSMITHKLINE LLC

US Patent


Assay Description
PI3Kinase Reaction Buffer was prepared by diluting the stock 1:4 with de-ionized water. Freshly prepared DTT was added at a final concentration of 5 ...


US Patent US10660898 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta


(Homo sapiens (Human))
BDBM444303
PNG
(US10660898, Example 18)
Show SMILES CCc1nc2c(F)cc(cc2n1Cc1cccc(Cl)c1Cl)N1CCOCC1
Show InChI InChI=1S/C20H20Cl2FN3O/c1-2-18-24-20-16(23)10-14(25-6-8-27-9-7-25)11-17(20)26(18)12-13-4-3-5-15(21)19(13)22/h3-5,10-11H,2,6-9,12H2,1H3
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GLAXOSMITHKLINE LLC

US Patent


Assay Description
PI3Kinase Reaction Buffer was prepared by diluting the stock 1:4 with de-ionized water. Freshly prepared DTT was added at a final concentration of 5 ...


US Patent US10660898 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta


(Homo sapiens (Human))
BDBM444308
PNG
(US10660898, Example 32)
Show SMILES Cc1nc2c(cc(cc2n1Cc1cccc(Cl)c1Cl)N1CCOCC1)C#N
Show InChI InChI=1S/C20H18Cl2N4O/c1-13-24-20-15(11-23)9-16(25-5-7-27-8-6-25)10-18(20)26(13)12-14-3-2-4-17(21)19(14)22/h2-4,9-10H,5-8,12H2,1H3
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GLAXOSMITHKLINE LLC

US Patent


Assay Description
PI3Kinase Reaction Buffer was prepared by diluting the stock 1:4 with de-ionized water. Freshly prepared DTT was added at a final concentration of 5 ...


US Patent US10660898 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta


(Homo sapiens (Human))
BDBM444305
PNG
(US10660898, Example 22)
Show SMILES Cc1nc2c(cc(cc2n1Cc1cccc(Cl)c1Cl)N1CCOCC1)C(O)=O
Show InChI InChI=1S/C20H19Cl2N3O3/c1-12-23-19-15(20(26)27)9-14(24-5-7-28-8-6-24)10-17(19)25(12)11-13-3-2-4-16(21)18(13)22/h2-4,9-10H,5-8,11H2,1H3,(H,26,27)
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GLAXOSMITHKLINE LLC

US Patent


Assay Description
PI3Kinase Reaction Buffer was prepared by diluting the stock 1:4 with de-ionized water. Freshly prepared DTT was added at a final concentration of 5 ...


US Patent US10660898 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta


(Homo sapiens (Human))
BDBM444322
PNG
(US10660898, Example 73)
Show SMILES Cc1nc2c(cc(cc2n1Cc1cccc2ccsc12)N1CCOCC1)C(O)=O
Show InChI InChI=1S/C22H21N3O3S/c1-14-23-20-18(22(26)27)11-17(24-6-8-28-9-7-24)12-19(20)25(14)13-16-4-2-3-15-5-10-29-21(15)16/h2-5,10-12H,6-9,13H2,1H3,(H,26,27)
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GLAXOSMITHKLINE LLC

US Patent


Assay Description
PI3Kinase Reaction Buffer was prepared by diluting the stock 1:4 with de-ionized water. Freshly prepared DTT was added at a final concentration of 5 ...


US Patent US10660898 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta


(Homo sapiens (Human))
BDBM444309
PNG
(US10660898, Example 35)
Show SMILES Cc1nc2c(cc(cc2n1Cc1cccc2cccnc12)N1CCOCC1)C(O)=O
Show InChI InChI=1S/C23H22N4O3/c1-15-25-22-19(23(28)29)12-18(26-8-10-30-11-9-26)13-20(22)27(15)14-17-5-2-4-16-6-3-7-24-21(16)17/h2-7,12-13H,8-11,14H2,1H3,(H,28,29)
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GLAXOSMITHKLINE LLC

US Patent


Assay Description
PI3Kinase Reaction Buffer was prepared by diluting the stock 1:4 with de-ionized water. Freshly prepared DTT was added at a final concentration of 5 ...


US Patent US10660898 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta


(Homo sapiens (Human))
BDBM444310
PNG
(US10660898, Example 38)
Show SMILES Cc1nc2c(cc(cc2n1Cc1ccc(Cl)c(Cl)c1)N1CCOCC1)C(O)=O
Show InChI InChI=1S/C20H19Cl2N3O3/c1-12-23-19-15(20(26)27)9-14(24-4-6-28-7-5-24)10-18(19)25(12)11-13-2-3-16(21)17(22)8-13/h2-3,8-10H,4-7,11H2,1H3,(H,26,27)
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GLAXOSMITHKLINE LLC

US Patent


Assay Description
PI3Kinase Reaction Buffer was prepared by diluting the stock 1:4 with de-ionized water. Freshly prepared DTT was added at a final concentration of 5 ...


US Patent US10660898 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta


(Homo sapiens (Human))
BDBM444296
PNG
(US10660898, Example 3)
Show SMILES CC(=O)Nc1cc(cc2n(Cc3cccc4ccccc34)c(C)nc12)N1CCOCC1
Show InChI InChI=1S/C25H26N4O2/c1-17-26-25-23(27-18(2)30)14-21(28-10-12-31-13-11-28)15-24(25)29(17)16-20-8-5-7-19-6-3-4-9-22(19)20/h3-9,14-15H,10-13,16H2,1-2H3,(H,27,30)
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GLAXOSMITHKLINE LLC

US Patent


Assay Description
PI3Kinase Reaction Buffer was prepared by diluting the stock 1:4 with de-ionized water. Freshly prepared DTT was added at a final concentration of 5 ...


US Patent US10660898 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%