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Patent code US10662184

Compile Data Set for Download or QSAR
Found 150 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM374028
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...)
Show SMILES CN([C@H]1CCN(Cc2ccccc2)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C21H23F2N5O2S2/c1-14-18(27(2)16-8-9-28(12-16)11-15-6-4-3-5-7-15)10-17(22)20(19(14)23)32(29,30)26-21-24-13-25-31-21/h3-7,10,13,16H,8-9,11-12H2,1-2H3,(H,24,25,26)/t16-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM374029
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...)
Show SMILES CN([C@H]1CCN(Cc2cccc(C)n2)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C21H24F2N6O2S2/c1-13-5-4-6-15(26-13)10-29-8-7-16(11-29)28(3)18-9-17(22)20(19(23)14(18)2)33(30,31)27-21-24-12-25-32-21/h4-6,9,12,16H,7-8,10-11H2,1-3H3,(H,24,25,27)/t16-/m0/s1
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n/an/a 2n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM374015
PNG
((R)-2,6-difluoro-3-methyl-4-((1-(1-phenylethyl)pip...)
Show SMILES C[C@@H](N1CCC(CC1)Oc1cc(F)c(c(F)c1C)S(=O)(=O)Nc1cscn1)c1ccccc1
Show InChI InChI=1S/C23H25F2N3O3S2/c1-15-20(12-19(24)23(22(15)25)33(29,30)27-21-13-32-14-26-21)31-18-8-10-28(11-9-18)16(2)17-6-4-3-5-7-17/h3-7,12-14,16,18,27H,8-11H2,1-2H3/t16-/m1/s1
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n/an/a 5n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM373891
PNG
((S)-4-((1-benzyl-3-methylpyrrolidin-3-yl)oxy)-2,6-...)
Show SMILES Cc1c(F)c(c(F)cc1O[C@@]1(C)CCN(Cc2ccccc2)C1)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C22H23F2N3O3S2/c1-15-18(30-22(2)8-9-27(13-22)11-16-6-4-3-5-7-16)10-17(23)21(20(15)24)32(28,29)26-19-12-31-14-25-19/h3-7,10,12,14,26H,8-9,11,13H2,1-2H3/t22-/m0/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM373837
PNG
((S)-2,6-difluoro-3-methyl-4-(methyl(1-((6-methylpy...)
Show SMILES CN(C1CCN(Cc2cccc(C)n2)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C22H25F2N5O2S2/c1-14-5-4-6-16(26-14)10-29-8-7-17(11-29)28(3)19-9-18(23)22(21(24)15(19)2)33(30,31)27-20-12-32-13-25-20/h4-6,9,12-13,17,27H,7-8,10-11H2,1-3H3
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM374012
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...)
Show SMILES CN([C@H]1CCN(Cc2ccccc2)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1ccsn1
Show InChI InChI=1S/C22H24F2N4O2S2/c1-15-19(27(2)17-8-10-28(14-17)13-16-6-4-3-5-7-16)12-18(23)22(21(15)24)32(29,30)26-20-9-11-31-25-20/h3-7,9,11-12,17H,8,10,13-14H2,1-2H3,(H,25,26)/t17-/m0/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM444553
PNG
((S)-3-chloro-2,6-difluoro-4-(methyl (1-((6-methylp...)
Show SMILES CN([C@H]1CCN(Cc2cccc(C)n2)C1)c1cc(F)c(c(F)c1Cl)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H21ClF2N6O2S2/c1-12-4-3-5-13(26-12)9-29-7-6-14(10-29)28(2)16-8-15(22)19(18(23)17(16)21)33(30,31)27-20-24-11-25-32-20/h3-5,8,11,14H,6-7,9-10H2,1-2H3,(H,24,25,27)/t14-/m0/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM373836
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...)
Show SMILES CN(C1CCN(Cc2ccccc2)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C22H24F2N4O2S2/c1-15-19(27(2)17-8-9-28(12-17)11-16-6-4-3-5-7-16)10-18(23)22(21(15)24)32(29,30)26-20-13-31-14-25-20/h3-7,10,13-14,17,26H,8-9,11-12H2,1-2H3
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM444506
PNG
(4-((trans-1-benzyl-4-methylpyrrolidin-3-yl)amino)-...)
Show SMILES C[C@H]1CN(Cc2ccccc2)C[C@@H]1Nc1ccc(cc1Cl)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C21H23ClN4O2S2/c1-15-12-26(13-16-5-3-2-4-6-16)14-20(15)24-19-8-7-17(11-18(19)22)30(27,28)25-21-23-9-10-29-21/h2-11,15,20,24H,12-14H2,1H3,(H,23,25)/t15-,20-/m0/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM374010
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2-f...)
Show SMILES CN([C@H]1CCN(Cc2ccccc2)C1)c1cc(F)c(cc1C)S(=O)(=O)Nc1ccsn1
Show InChI InChI=1S/C22H25FN4O2S2/c1-16-12-21(31(28,29)25-22-9-11-30-24-22)19(23)13-20(16)26(2)18-8-10-27(15-18)14-17-6-4-3-5-7-17/h3-7,9,11-13,18H,8,10,14-15H2,1-2H3,(H,24,25)/t18-/m0/s1
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n/an/a 27n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM373764
PNG
((S)-3-chloro-4-((1-(3-(difluoromethyl)benzyl)pyrro...)
Show SMILES CN([C@H]1CCN(Cc2cccc(c2)C(F)F)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C21H22ClF2N5O2S2/c1-28(16-7-8-29(12-16)11-14-3-2-4-15(9-14)20(23)24)19-6-5-17(10-18(19)22)33(30,31)27-21-25-13-26-32-21/h2-6,9-10,13,16,20H,7-8,11-12H2,1H3,(H,25,26,27)/t16-/m0/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM373749
PNG
(4-(((1R,3s,5S)-8-benzyl-8-azabicyclo[3.2.1]octan-3...)
Show SMILES Clc1cc(ccc1O[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccccc1)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C23H24ClN3O3S2/c24-21-14-20(32(28,29)26-23-25-10-11-31-23)8-9-22(21)30-19-12-17-6-7-18(13-19)27(17)15-16-4-2-1-3-5-16/h1-5,8-11,14,17-19H,6-7,12-13,15H2,(H,25,26)/t17-,18+,19-
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM373788
PNG
((R)-3-chloro-4-((1-(1-phenylethyl)piperidin-4-yl)o...)
Show SMILES C[C@@H](N1CCC(CC1)Oc1ccc(cc1Cl)S(=O)(=O)Nc1nccs1)c1ccccc1
Show InChI InChI=1S/C22H24ClN3O3S2/c1-16(17-5-3-2-4-6-17)26-12-9-18(10-13-26)29-21-8-7-19(15-20(21)23)31(27,28)25-22-24-11-14-30-22/h2-8,11,14-16,18H,9-10,12-13H2,1H3,(H,24,25)/t16-/m1/s1
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n/an/a 32n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM373839
PNG
(4-((1-benzylpiperidin-4-yl)oxy)-2,6-difluoro-3-met...)
Show SMILES Cc1c(F)c(c(F)cc1OC1CCN(Cc2ccccc2)CC1)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C22H23F2N3O3S2/c1-15-19(30-17-7-9-27(10-8-17)12-16-5-3-2-4-6-16)11-18(23)22(21(15)24)32(28,29)26-20-13-31-14-25-20/h2-6,11,13-14,17,26H,7-10,12H2,1H3
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM373761
PNG
((S)-3-chloro-4-((1-(3-(difluoromethyl)benzyl)pyrro...)
Show SMILES CN([C@H]1CCN(Cc2cccc(c2)C(F)F)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C22H23ClF2N4O2S2/c1-28(17-7-9-29(14-17)13-15-3-2-4-16(11-15)21(24)25)20-6-5-18(12-19(20)23)33(30,31)27-22-26-8-10-32-22/h2-6,8,10-12,17,21H,7,9,13-14H2,1H3,(H,26,27)/t17-/m0/s1
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n/an/a 36n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM444511
PNG
((S)-3-chloro-4-(methyl(1-(3- methylbenzyl)pyrrolid...)
Show SMILES Cc1cccc(CN2CC[C@@H](C2)Nc2ccc(cc2Cl)S(=O)(=O)Nc2ncns2)c1
Show InChI InChI=1S/C20H22ClN5O2S2/c1-14-3-2-4-15(9-14)11-26-8-7-16(12-26)24-19-6-5-17(10-18(19)21)30(27,28)25-20-22-13-23-29-20/h2-6,9-10,13,16,24H,7-8,11-12H2,1H3,(H,22,23,25)/t16-/m0/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM374016
PNG
((R)-2,6-difluoro-3-methyl-4-((1-(1-phenylethyl)pip...)
Show SMILES C[C@@H](N1CCC(CC1)Oc1cc(F)c(c(F)c1Cl)S(=O)(=O)Nc1cscn1)c1ccccc1
Show InChI InChI=1S/C22H22ClF2N3O3S2/c1-14(15-5-3-2-4-6-15)28-9-7-16(8-10-28)31-18-11-17(24)22(21(25)20(18)23)33(29,30)27-19-12-32-13-26-19/h2-6,11-14,16,27H,7-10H2,1H3/t14-/m1/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM444513
PNG
((R)-5-chloro-2-fluoro-4-(1-(3- methylbenzyl)pyrrol...)
Show SMILES Cc1cccc(c1)N1CC[C@@H](C1)Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C20H20ClFN4O2S2/c1-13-3-2-4-15(9-13)26-7-5-14(12-26)24-18-11-17(22)19(10-16(18)21)30(27,28)25-20-23-6-8-29-20/h2-4,6,8-11,14,24H,5,7,12H2,1H3,(H,23,25)/t14-/m0/s1
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n/an/a 39n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM374031
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...)
Show SMILES CN([C@H]1CCN(Cc2ccccc2)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1cccc(F)n1
Show InChI InChI=1S/C24H25F3N4O2S/c1-16-20(30(2)18-11-12-31(15-18)14-17-7-4-3-5-8-17)13-19(25)24(23(16)27)34(32,33)29-22-10-6-9-21(26)28-22/h3-10,13,18H,11-12,14-15H2,1-2H3,(H,28,29)/t18-/m0/s1
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n/an/a 43n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM373834
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2-f...)
Show SMILES CN(C1CCN(Cc2ccccc2)C1)c1cc(F)c(cc1C)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C22H25FN4O2S2/c1-16-10-21(31(28,29)25-22-14-30-15-24-22)19(23)11-20(16)26(2)18-8-9-27(13-18)12-17-6-4-3-5-7-17/h3-7,10-11,14-15,18,25H,8-9,12-13H2,1-2H3
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n/an/a 54n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM373815
PNG
(3-chloro-4-(1-((6-methylpyridin-2-yl)methyl)piperi...)
Show SMILES Cc1cccc(CN2CCC(CC2)Oc2ccc(cc2Cl)S(=O)(=O)Nc2nccs2)n1
Show InChI InChI=1S/C21H23ClN4O3S2/c1-15-3-2-4-16(24-15)14-26-10-7-17(8-11-26)29-20-6-5-18(13-19(20)22)31(27,28)25-21-23-9-12-30-21/h2-6,9,12-13,17H,7-8,10-11,14H2,1H3,(H,23,25)
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n/an/a 56n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM373762
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-3-c...)
Show SMILES CN([C@H]1CCN(Cc2ccccc2)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H22ClN5O2S2/c1-25(16-9-10-26(13-16)12-15-5-3-2-4-6-15)19-8-7-17(11-18(19)21)30(27,28)24-20-22-14-23-29-20/h2-8,11,14,16H,9-10,12-13H2,1H3,(H,22,23,24)/t16-/m0/s1
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n/an/a 60n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM374000
PNG
((S)-3-chloro-2,6-difluoro-4-(methyl(1-((6-methylpy...)
Show SMILES CN([C@H]1CCN(Cc2cccc(C)n2)C1)c1cc(F)c(c(F)c1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C21H22ClF2N5O2S2/c1-13-4-3-5-14(26-13)9-29-7-6-15(10-29)28(2)17-8-16(23)21(20(24)19(17)22)33(30,31)27-18-11-32-12-25-18/h3-5,8,11-12,15,27H,6-7,9-10H2,1-2H3/t15-/m0/s1
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n/an/a 66n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM373766
PNG
((S)-3-chloro-4-((1-(5-chloro-2-fluorobenzyl)pyrrol...)
Show SMILES CN([C@H]1CCN(Cc2cc(Cl)ccc2F)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H20Cl2FN5O2S2/c1-27(15-6-7-28(11-15)10-13-8-14(21)2-4-18(13)23)19-5-3-16(9-17(19)22)32(29,30)26-20-24-12-25-31-20/h2-5,8-9,12,15H,6-7,10-11H2,1H3,(H,24,25,26)/t15-/m0/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM373760
PNG
((S)-3-chloro-4-((1-(3-chlorobenzyl)pyrrolidin-3-yl...)
Show SMILES CN([C@H]1CCN(Cc2cccc(Cl)c2)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C21H22Cl2N4O2S2/c1-26(17-7-9-27(14-17)13-15-3-2-4-16(22)11-15)20-6-5-18(12-19(20)23)31(28,29)25-21-24-8-10-30-21/h2-6,8,10-12,17H,7,9,13-14H2,1H3,(H,24,25)/t17-/m0/s1
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n/an/a 70n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM373825
PNG
(3-chloro-4-(1-(3-methylbenzyl)piperidin-4-yloxy)-N...)
Show SMILES Cc1cccc(CN2CCC(CC2)Oc2ccc(cc2Cl)S(=O)(=O)Nc2nccs2)c1
Show InChI InChI=1S/C22H24ClN3O3S2/c1-16-3-2-4-17(13-16)15-26-10-7-18(8-11-26)29-21-6-5-19(14-20(21)23)31(27,28)25-22-24-9-12-30-22/h2-6,9,12-14,18H,7-8,10-11,15H2,1H3,(H,24,25)
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n/an/a 81n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM373744
PNG
(3-chloro-4-((1-(3-(difluoromethyl)benzyl)piperidin...)
Show SMILES FC(F)c1cccc(CN2CCC(CC2)Oc2ccc(cc2Cl)S(=O)(=O)Nc2nccs2)c1
Show InChI InChI=1S/C22H22ClF2N3O3S2/c23-19-13-18(33(29,30)27-22-26-8-11-32-22)4-5-20(19)31-17-6-9-28(10-7-17)14-15-2-1-3-16(12-15)21(24)25/h1-5,8,11-13,17,21H,6-7,9-10,14H2,(H,26,27)
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n/an/a 82n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM373777
PNG
(3-chloro-4-(methyl((S)-1-((R)-1-phenylethyl)pyrrol...)
Show SMILES C[C@@H](N1CC[C@@H](C1)N(C)c1ccc(cc1Cl)S(=O)(=O)Nc1nccs1)c1ccccc1
Show InChI InChI=1S/C22H25ClN4O2S2/c1-16(17-6-4-3-5-7-17)27-12-10-18(15-27)26(2)21-9-8-19(14-20(21)23)31(28,29)25-22-24-11-13-30-22/h3-9,11,13-14,16,18H,10,12,15H2,1-2H3,(H,24,25)/t16-,18+/m1/s1
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n/an/a 89n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM444514
PNG
((R)-4-(1-benzylpyrrolidin-3-ylamino)-5-chloro- 2-f...)
Show SMILES Fc1cc(N[C@@H]2CCN(C2)c2ccccc2)c(Cl)cc1S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C19H18ClFN4O2S2/c20-15-10-18(29(26,27)24-19-22-7-9-28-19)16(21)11-17(15)23-13-6-8-25(12-13)14-4-2-1-3-5-14/h1-5,7,9-11,13,23H,6,8,12H2,(H,22,24)/t13-/m1/s1
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n/an/a 91n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM373792
PNG
(3-chloro-4-((1-(2-phenylpropan-2-yl)piperidin-4-yl...)
Show SMILES CC(C)(N1CCC(CC1)Oc1ccc(cc1Cl)S(=O)(=O)Nc1nccs1)c1ccccc1
Show InChI InChI=1S/C23H26ClN3O3S2/c1-23(2,17-6-4-3-5-7-17)27-13-10-18(11-14-27)30-21-9-8-19(16-20(21)24)32(28,29)26-22-25-12-15-31-22/h3-9,12,15-16,18H,10-11,13-14H2,1-2H3,(H,25,26)
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM444497
PNG
((S)-3-chloro-4-((1-(1-phenylethyl)piperidin-4-yl)o...)
Show SMILES C[C@H](N1CCC(CC1)Oc1ccc(cc1Cl)S(=O)(=O)Nc1nccs1)c1ccccc1
Show InChI InChI=1S/C22H24ClN3O3S2/c1-16(17-5-3-2-4-6-17)26-12-9-18(10-13-26)29-21-8-7-19(15-20(21)23)31(27,28)25-22-24-11-14-30-22/h2-8,11,14-16,18H,9-10,12-13H2,1H3,(H,24,25)/t16-/m0/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM373954
PNG
((S)-3-chloro-4-((1-(1-phenylethyl)piperidin-4-yl)o...)
Show SMILES C[C@H](N1CCC(CC1)Oc1ccc(cc1Cl)S(=O)(=O)Nc1ncns1)c1ccccc1
Show InChI InChI=1S/C21H23ClN4O3S2/c1-15(16-5-3-2-4-6-16)26-11-9-17(10-12-26)29-20-8-7-18(13-19(20)22)31(27,28)25-21-23-14-24-30-21/h2-8,13-15,17H,9-12H2,1H3,(H,23,24,25)/t15-/m0/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM444536
PNG
(5-chloro-4-(((S)-1-((S)-2,3-dihydro-1H-inden-1-yl)...)
Show SMILES CN([C@H]1CCN(C1)C1CCc2ccccc12)c1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C23H24ClFN4O2S2/c1-28(16-8-9-29(12-16)20-7-6-15-4-2-3-5-17(15)20)21-11-19(25)22(10-18(21)24)33(30,31)27-23-13-32-14-26-23/h2-5,10-11,13-14,16,20,27H,6-9,12H2,1H3/t16-,20?/m0/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM444509
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)- 3-...)
Show SMILES CN([C@H]1CCN(C1)c1ccccc1)c1ccc(cc1Cl)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C20H21ClN4O2S2/c1-24(16-9-11-25(14-16)15-5-3-2-4-6-15)19-8-7-17(13-18(19)21)29(26,27)23-20-22-10-12-28-20/h2-8,10,12-13,16H,9,11,14H2,1H3,(H,22,23)/t16-/m0/s1
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n/an/a 124n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM374055
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2-f...)
Show SMILES CN([C@H]1CCN(Cc2ccccc2)C1)c1ccc(c(F)c1C)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C22H25FN4O2S2/c1-16-19(8-9-20(22(16)23)31(28,29)25-21-14-30-15-24-21)26(2)18-10-11-27(13-18)12-17-6-4-3-5-7-17/h3-9,14-15,18,25H,10-13H2,1-2H3/t18-/m0/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM373794
PNG
(4-((1-benzyl-3-methylpyrrolidin-3-yl)amino)-3-chlo...)
Show SMILES CC1(CCN(Cc2ccccc2)C1)Nc1ccc(cc1Cl)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C21H23ClN4O2S2/c1-21(9-11-26(15-21)14-16-5-3-2-4-6-16)24-19-8-7-17(13-18(19)22)30(27,28)25-20-23-10-12-29-20/h2-8,10,12-13,24H,9,11,14-15H2,1H3,(H,23,25)
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM444508
PNG
((R)-4-(1-benzylpyrrolidin-3-ylamino)-3-chloro- N-(...)
Show SMILES Clc1cc(ccc1N[C@@H]1CCN(C1)c1ccccc1)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C19H19ClN4O2S2/c20-17-12-16(28(25,26)23-19-21-9-11-27-19)6-7-18(17)22-14-8-10-24(13-14)15-4-2-1-3-5-15/h1-7,9,11-12,14,22H,8,10,13H2,(H,21,23)/t14-/m1/s1
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n/an/a 138n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM373758
PNG
(4-((1-benzyl-3-methylazetidin-3-yl)amino)-3-chloro...)
Show SMILES CC1(CN(Cc2ccccc2)C1)Nc1ccc(cc1Cl)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C20H21ClN4O2S2/c1-20(13-25(14-20)12-15-5-3-2-4-6-15)23-18-8-7-16(11-17(18)21)29(26,27)24-19-22-9-10-28-19/h2-11,23H,12-14H2,1H3,(H,22,24)
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n/an/a 138n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM373799
PNG
((R)-4-((1-benzylpyrrolidin-3-yl)amino)-3-chloro-N-...)
Show SMILES Clc1cc(ccc1N[C@@H]1CCN(Cc2ccccc2)C1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C19H20ClN5O2S2/c20-17-10-16(29(26,27)24-19-21-13-22-28-19)6-7-18(17)23-15-8-9-25(12-15)11-14-4-2-1-3-5-14/h1-7,10,13,15,23H,8-9,11-12H2,(H,21,22,24)/t15-/m1/s1
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n/an/a 144n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM373795
PNG
((S)-3-chloro-4-(methyl(1-(2-phenylpropan-2-yl)pyrr...)
Show SMILES CN([C@H]1CCN(C1)C(C)(C)c1ccccc1)c1ccc(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C23H27ClN4O2S2/c1-23(2,17-7-5-4-6-8-17)28-12-11-18(14-28)27(3)21-10-9-19(13-20(21)24)32(29,30)26-22-15-31-16-25-22/h4-10,13,15-16,18,26H,11-12,14H2,1-3H3/t18-/m0/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM373838
PNG
(4-((1-benzylpiperidin-4-yl)oxy)-3-chloro-2,6-diflu...)
Show SMILES Fc1cc(OC2CCN(Cc3ccccc3)CC2)c(Cl)c(F)c1S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C21H20ClF2N3O3S2/c22-19-17(30-15-6-8-27(9-7-15)11-14-4-2-1-3-5-14)10-16(23)21(20(19)24)32(28,29)26-18-12-31-13-25-18/h1-5,10,12-13,15,26H,6-9,11H2
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n/an/a 151n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM373835
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-3-c...)
Show SMILES CN(C1CCN(Cc2ccccc2)C1)c1cc(F)c(c(F)c1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C21H21ClF2N4O2S2/c1-27(15-7-8-28(11-15)10-14-5-3-2-4-6-14)17-9-16(23)21(20(24)19(17)22)32(29,30)26-18-12-31-13-25-18/h2-6,9,12-13,15,26H,7-8,10-11H2,1H3
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n/an/a 152n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM373750
PNG
(4-(((1R,3s,5S)-8-benzyl-8-azabicyclo[3.2.1]octan-3...)
Show SMILES Fc1cc(O[C@H]2C[C@@H]3CC[C@H](C2)N3Cc2ccccc2)c(Cl)cc1S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C23H23ClFN3O3S2/c24-19-12-22(33(29,30)27-23-26-8-9-32-23)20(25)13-21(19)31-18-10-16-6-7-17(11-18)28(16)14-15-4-2-1-3-5-15/h1-5,8-9,12-13,16-18H,6-7,10-11,14H2,(H,26,27)/t16-,17+,18-
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n/an/a 155n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM373833
PNG
(4-(1-benzylpiperidin-4-yloxy)-3-chloro-N-(1,2,4-th...)
Show SMILES Clc1cc(ccc1OC1CCN(Cc2ccccc2)CC1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H21ClN4O3S2/c21-18-12-17(30(26,27)24-20-22-14-23-29-20)6-7-19(18)28-16-8-10-25(11-9-16)13-15-4-2-1-3-5-15/h1-7,12,14,16H,8-11,13H2,(H,22,23,24)
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM373759
PNG
(4-((1-benzylpyrrolidin-3-yl)amino)-3-chloro-N-(1,2...)
Show SMILES Clc1cc(ccc1NC1CCN(Cc2ccccc2)C1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C19H20ClN5O2S2/c20-17-10-16(29(26,27)24-19-21-13-22-28-19)6-7-18(17)23-15-8-9-25(12-15)11-14-4-2-1-3-5-14/h1-7,10,13,15,23H,8-9,11-12H2,(H,21,22,24)
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM373990
PNG
((S)-5-chloro-2-fluoro-4-(methyl(1-(2-phenylpropan-...)
Show SMILES CN([C@H]1CCN(C1)C(C)(C)c1ccccc1)c1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C23H26ClFN4O2S2/c1-23(2,16-7-5-4-6-8-16)29-10-9-17(13-29)28(3)20-12-19(25)21(11-18(20)24)33(30,31)27-22-14-32-15-26-22/h4-8,11-12,14-15,17,27H,9-10,13H2,1-3H3/t17-/m0/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM373828
PNG
(4-(1-benzylpiperidin-4-yloxy)-3-chloro-N-(thiazol-...)
Show SMILES Clc1cc(ccc1OC1CCN(Cc2ccccc2)CC1)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C21H22ClN3O3S2/c22-19-14-18(30(26,27)24-21-23-10-13-29-21)6-7-20(19)28-17-8-11-25(12-9-17)15-16-4-2-1-3-5-16/h1-7,10,13-14,17H,8-9,11-12,15H2,(H,23,24)
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM373790
PNG
((R)-3-chloro-4-((1-(1-phenylethyl)piperidin-4-yl)o...)
Show SMILES C[C@@H](N1CCC(CC1)Oc1ccc(cc1Cl)S(=O)(=O)Nc1cscn1)c1ccccc1
Show InChI InChI=1S/C22H24ClN3O3S2/c1-16(17-5-3-2-4-6-17)26-11-9-18(10-12-26)29-21-8-7-19(13-20(21)23)31(27,28)25-22-14-30-15-24-22/h2-8,13-16,18,25H,9-12H2,1H3/t16-/m1/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM373955
PNG
((R)-5-chloro-2-fluoro-4-((1-(1-phenylethyl)piperid...)
Show SMILES C[C@@H](N1CCC(CC1)Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1)c1ccccc1
Show InChI InChI=1S/C22H23ClFN3O3S2/c1-15(16-5-3-2-4-6-16)27-9-7-17(8-10-27)30-20-12-19(24)21(11-18(20)23)32(28,29)26-22-13-31-14-25-22/h2-6,11-15,17,26H,7-10H2,1H3/t15-/m1/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM373779
PNG
(4-((1-benzylpiperidin-4-yl)amino)-3-chloro-N-(1,2,...)
Show SMILES Clc1cc(ccc1NC1CCN(Cc2ccccc2)CC1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H22ClN5O2S2/c21-18-12-17(30(27,28)25-20-22-14-23-29-20)6-7-19(18)24-16-8-10-26(11-9-16)13-15-4-2-1-3-5-15/h1-7,12,14,16,24H,8-11,13H2,(H,22,23,25)
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM374002
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)oxy)-2,6-difluoro-...)
Show SMILES Cc1c(F)c(c(F)cc1O[C@H]1CCN(Cc2ccccc2)C1)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C21H21F2N3O3S2/c1-14-18(29-16-7-8-26(11-16)10-15-5-3-2-4-6-15)9-17(22)21(20(14)23)31(27,28)25-19-12-30-13-24-19/h2-6,9,12-13,16,25H,7-8,10-11H2,1H3/t16-/m0/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM373926
PNG
((S)-5-chloro-4-((1-(3-(difluoromethyl)benzyl)-pyrr...)
Show SMILES CN([C@H]1CCN(Cc2cccc(c2)C(F)F)C1)c1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C22H22ClF3N4O2S2/c1-29(16-5-6-30(11-16)10-14-3-2-4-15(7-14)22(25)26)19-9-18(24)20(8-17(19)23)34(31,32)28-21-12-33-13-27-21/h2-4,7-9,12-13,16,22,28H,5-6,10-11H2,1H3/t16-/m0/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM444527
PNG
((S)-5-chloro-2-fluoro-4- (methyl(1-((6-methylpyrid...)
Show SMILES C[C@@]1(CCN(Cc2ccccc2)C1)Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C21H22ClFN4O2S2/c1-21(7-8-27(13-21)11-15-5-3-2-4-6-15)25-18-10-17(23)19(9-16(18)22)31(28,29)26-20-12-30-14-24-20/h2-6,9-10,12,14,25-26H,7-8,11,13H2,1H3/t21-/m0/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM374049
PNG
((R)-3-chloro-4-((1-(1-(5-chloro-2-fluorophenyl)eth...)
Show SMILES C[C@@H](N1CCC(CC1)Oc1ccc(cc1Cl)S(=O)(=O)Nc1cscn1)c1cc(Cl)ccc1F
Show InChI InChI=1S/C22H22Cl2FN3O3S2/c1-14(18-10-15(23)2-4-20(18)25)28-8-6-16(7-9-28)31-21-5-3-17(11-19(21)24)33(29,30)27-22-12-32-13-26-22/h2-5,10-14,16,27H,6-9H2,1H3/t14-/m1/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM373732
PNG
(4-((1-benzyl-3,3-dimethylpiperidin-4-yl)oxy)-3-chl...)
Show SMILES CC1(C)CN(Cc2ccccc2)CCC1Oc1ccc(cc1Cl)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C22H25ClN4O3S2/c1-22(2)14-27(13-16-6-4-3-5-7-16)11-10-20(22)30-19-9-8-17(12-18(19)23)32(28,29)26-21-24-15-25-31-21/h3-9,12,15,20H,10-11,13-14H2,1-2H3,(H,24,25,26)
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM373820
PNG
((S)-4-(1-benzylpyrrolidin-3-ylamino)-5-chloro-2-fl...)
Show SMILES Fc1cc(N[C@H]2CCN(Cc3ccccc3)C2)c(Cl)cc1S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C20H20ClFN4O2S2/c21-16-10-19(30(27,28)25-20-23-7-9-29-20)17(22)11-18(16)24-15-6-8-26(13-15)12-14-4-2-1-3-5-14/h1-5,7,9-11,15,24H,6,8,12-13H2,(H,23,25)/t15-/m0/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM373984
PNG
(3-chloro-4-(methyl((S)-1-((R)-1-phenylethyl)pyrrol...)
Show SMILES C[C@@H](N1CC[C@@H](C1)N(C)c1ccc(cc1Cl)S(=O)(=O)Nc1cscn1)c1ccccc1
Show InChI InChI=1S/C22H25ClN4O2S2/c1-16(17-6-4-3-5-7-17)27-11-10-18(13-27)26(2)21-9-8-19(12-20(21)23)31(28,29)25-22-14-30-15-24-22/h3-9,12,14-16,18,25H,10-11,13H2,1-2H3/t16-,18+/m1/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM373992
PNG
((S)-5-chloro-2-fluoro-4-(methyl(1-(1-phenylcyclopr...)
Show SMILES CN([C@H]1CCN(C1)C1(CC1)c1ccccc1)c1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C23H24ClFN4O2S2/c1-28(17-7-10-29(13-17)23(8-9-23)16-5-3-2-4-6-16)20-12-19(25)21(11-18(20)24)33(30,31)27-22-14-32-15-26-22/h2-6,11-12,14-15,17,27H,7-10,13H2,1H3/t17-/m0/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM374024
PNG
((R)-2,6-difluoro-4-((1-(1-phenylethyl)piperidin-4-...)
Show SMILES C[C@@H](N1CCC(CC1)Oc1cc(F)c(c(F)c1)S(=O)(=O)Nc1cscn1)c1ccccc1
Show InChI InChI=1S/C22H23F2N3O3S2/c1-15(16-5-3-2-4-6-16)27-9-7-17(8-10-27)30-18-11-19(23)22(20(24)12-18)32(28,29)26-21-13-31-14-25-21/h2-6,11-15,17,26H,7-10H2,1H3/t15-/m1/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM373800
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)amino)-3-chloro-N-...)
Show SMILES Clc1cc(ccc1N[C@H]1CCN(Cc2ccccc2)C1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C19H20ClN5O2S2/c20-17-10-16(29(26,27)24-19-21-13-22-28-19)6-7-18(17)23-15-8-9-25(12-15)11-14-4-2-1-3-5-14/h1-7,10,13,15,23H,8-9,11-12H2,(H,21,22,24)/t15-/m0/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM373939
PNG
((S)-5-chloro-2-fluoro-4-((1-(2-methoxybenzyl)pyrro...)
Show SMILES COc1ccccc1CN1CC[C@@H](C1)N(C)c1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C22H24ClFN4O3S2/c1-27(16-7-8-28(12-16)11-15-5-3-4-6-20(15)31-2)19-10-18(24)21(9-17(19)23)33(29,30)26-22-13-32-14-25-22/h3-6,9-10,13-14,16,26H,7-8,11-12H2,1-2H3/t16-/m0/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM373780
PNG
(4-((1-benzylpiperidin-4-yl)oxy)-5-chloro-2-fluoro-...)
Show SMILES Fc1cc(OC2CCN(Cc3ccccc3)CC2)c(Cl)cc1S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C21H21ClFN3O3S2/c22-17-12-20(31(27,28)25-21-24-8-11-30-21)18(23)13-19(17)29-16-6-9-26(10-7-16)14-15-4-2-1-3-5-15/h1-5,8,11-13,16H,6-7,9-10,14H2,(H,24,25)
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM373986
PNG
((S)-3-chloro-4-((1-(3-(difluoromethyl)benzyl)pyrro...)
Show SMILES CN([C@H]1CCN(Cc2cccc(c2)C(F)F)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C22H23ClF2N4O2S2/c1-28(17-7-8-29(12-17)11-15-3-2-4-16(9-15)22(24)25)20-6-5-18(10-19(20)23)33(30,31)27-21-13-32-14-26-21/h2-6,9-10,13-14,17,22,27H,7-8,11-12H2,1H3/t17-/m0/s1
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n/an/a 491n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM373975
PNG
(5-chloro-2-fluoro-4-(methyl((S)-1-((S)-1-phenylpro...)
Show SMILES CC[C@H](N1CC[C@@H](C1)N(C)c1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1)c1ccccc1
Show InChI InChI=1S/C23H26ClFN4O2S2/c1-3-20(16-7-5-4-6-8-16)29-10-9-17(13-29)28(2)21-12-19(25)22(11-18(21)24)33(30,31)27-23-14-32-15-26-23/h4-8,11-12,14-15,17,20,27H,3,9-10,13H2,1-2H3/t17-,20-/m0/s1
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n/an/a 668n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM373769
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(ethyl)amino)-3-ch...)
Show SMILES CCN([C@H]1CCN(Cc2ccccc2)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C21H24ClN5O2S2/c1-2-27(17-10-11-26(14-17)13-16-6-4-3-5-7-16)20-9-8-18(12-19(20)22)31(28,29)25-21-23-15-24-30-21/h3-9,12,15,17H,2,10-11,13-14H2,1H3,(H,23,24,25)/t17-/m0/s1
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n/an/a 685n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM373774
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-3-c...)
Show SMILES CN([C@H]1CCN(Cc2ccccc2)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C21H23ClN4O2S2/c1-25(17-9-10-26(13-17)12-16-5-3-2-4-6-16)20-8-7-18(11-19(20)22)30(27,28)24-21-14-29-15-23-21/h2-8,11,14-15,17,24H,9-10,12-13H2,1H3/t17-/m0/s1
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n/an/a 748n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM373771
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-5-c...)
Show SMILES CN([C@H]1CCN(Cc2ccccc2)C1)c1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C21H22ClFN4O2S2/c1-26(16-7-8-27(12-16)11-15-5-3-2-4-6-15)19-10-18(23)20(9-17(19)22)31(28,29)25-21-13-30-14-24-21/h2-6,9-10,13-14,16,25H,7-8,11-12H2,1H3/t16-/m0/s1
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n/an/a 803n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM373798
PNG
(3-chloro-4-((1-(pyridin-2-ylmethyl)piperidin-4-yl)...)
Show SMILES Clc1cc(ccc1OC1CCN(Cc2ccccn2)CC1)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C20H21ClN4O3S2/c21-18-13-17(30(26,27)24-20-23-9-12-29-20)4-5-19(18)28-16-6-10-25(11-7-16)14-15-3-1-2-8-22-15/h1-5,8-9,12-13,16H,6-7,10-11,14H2,(H,23,24)
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n/an/a 839n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM373993
PNG
((S)-5-chloro-2-fluoro-N-(6-fluoropyridin-2-yl)-4-(...)
Show SMILES CN([C@H]1CCN(C1)C(C)(C)c1ccccc1)c1cc(F)c(cc1Cl)S(=O)(=O)Nc1cccc(F)n1
Show InChI InChI=1S/C25H27ClF2N4O2S/c1-25(2,17-8-5-4-6-9-17)32-13-12-18(16-32)31(3)21-15-20(27)22(14-19(21)26)35(33,34)30-24-11-7-10-23(28)29-24/h4-11,14-15,18H,12-13,16H2,1-3H3,(H,29,30)/t18-/m0/s1
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n/an/a 842n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM373804
PNG
((R)-3-chloro-4-((1-(2-fluorobenzyl)pyrrolidin-3-yl...)
Show SMILES Fc1ccccc1CN1CC[C@H](C1)Nc1ccc(cc1Cl)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C20H20ClFN4O2S2/c21-17-11-16(30(27,28)25-20-23-8-10-29-20)5-6-19(17)24-15-7-9-26(13-15)12-14-3-1-2-4-18(14)22/h1-6,8,10-11,15,24H,7,9,12-13H2,(H,23,25)/t15-/m1/s1
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n/an/a 863n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM374033
PNG
((R)-3-chloro-4-((1-(1-phenylethyl)piperidin-4-yl)o...)
Show SMILES C[C@@H](N1CCC(CC1)Oc1ccc(cc1Cl)S(=O)(=O)Nc1ccncn1)c1ccccc1
Show InChI InChI=1S/C23H25ClN4O3S/c1-17(18-5-3-2-4-6-18)28-13-10-19(11-14-28)31-22-8-7-20(15-21(22)24)32(29,30)27-23-9-12-25-16-26-23/h2-9,12,15-17,19H,10-11,13-14H2,1H3,(H,25,26,27)/t17-/m1/s1
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n/an/a 972n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM444506
PNG
(4-((trans-1-benzyl-4-methylpyrrolidin-3-yl)amino)-...)
Show SMILES C[C@H]1CN(Cc2ccccc2)C[C@@H]1Nc1ccc(cc1Cl)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C21H23ClN4O2S2/c1-15-12-26(13-16-5-3-2-4-6-16)14-20(15)24-19-8-7-17(11-18(19)22)30(27,28)25-21-23-9-10-29-21/h2-11,15,20,24H,12-14H2,1H3,(H,23,25)/t15-,20-/m0/s1
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n/an/a 1.03E+3n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM373979
PNG
(5-chloro-4-(((S)-1-((R)-2,3-dihydro-1H-inden-1-yl)...)
Show SMILES CN([C@H]1CCN(C1)[C@@H]1CCc2ccccc12)c1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C23H24ClFN4O2S2/c1-28(16-8-9-29(12-16)20-7-6-15-4-2-3-5-17(15)20)21-11-19(25)22(10-18(21)24)33(30,31)27-23-13-32-14-26-23/h2-5,10-11,13-14,16,20,27H,6-9,12H2,1H3/t16-,20+/m0/s1
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n/an/a 1.03E+3n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM374052
PNG
(4-(((1R,3s,5S)-8-benzyl-8-azabicyclo[3.2.1]octan-3...)
Show SMILES Clc1cc(ccc1O[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccccc1)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C23H24ClN3O3S2/c24-21-12-20(32(28,29)26-23-14-31-15-25-23)8-9-22(21)30-19-10-17-6-7-18(11-19)27(17)13-16-4-2-1-3-5-16/h1-5,8-9,12,14-15,17-19,26H,6-7,10-11,13H2/t17-,18+,19-
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n/an/a 1.15E+3n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM444513
PNG
((R)-5-chloro-2-fluoro-4-(1-(3- methylbenzyl)pyrrol...)
Show SMILES Cc1cccc(c1)N1CC[C@@H](C1)Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C20H20ClFN4O2S2/c1-13-3-2-4-15(9-13)26-7-5-14(12-26)24-18-11-17(22)19(10-16(18)21)30(27,28)25-20-23-6-8-29-20/h2-4,6,8-11,14,24H,5,7,12H2,1H3,(H,23,25)/t14-/m0/s1
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n/an/a 1.25E+3n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM444514
PNG
((R)-4-(1-benzylpyrrolidin-3-ylamino)-5-chloro- 2-f...)
Show SMILES Fc1cc(N[C@@H]2CCN(C2)c2ccccc2)c(Cl)cc1S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C19H18ClFN4O2S2/c20-15-10-18(29(26,27)24-19-22-7-9-28-19)16(21)11-17(15)23-13-6-8-25(12-13)14-4-2-1-3-5-14/h1-5,7,9-11,13,23H,6,8,12H2,(H,22,24)/t13-/m1/s1
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n/an/a 2.87E+3n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM373801
PNG
((R)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-3-c...)
Show SMILES CN([C@@H]1CCN(Cc2ccccc2)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H22ClN5O2S2/c1-25(16-9-10-26(13-16)12-15-5-3-2-4-6-15)19-8-7-17(11-18(19)21)30(27,28)24-20-22-14-23-29-20/h2-8,11,14,16H,9-10,12-13H2,1H3,(H,22,23,24)/t16-/m1/s1
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n/an/a 2.92E+3n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM444517
PNG
((S)-4-(1-benzylpyrrolidin-3-yloxy)-3-chloro-N- (1,...)
Show SMILES Fc1cc(O[C@H]2CCN(Cc3ccccc3)C2)c(Cl)cc1S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C19H18ClFN4O3S2/c20-15-8-18(30(26,27)24-19-22-12-23-29-19)16(21)9-17(15)28-14-6-7-25(11-14)10-13-4-2-1-3-5-13/h1-5,8-9,12,14H,6-7,10-11H2,(H,22,23,24)/t14-/m0/s1
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n/an/a 2.94E+3n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM373959
PNG
((S)-4-((1-benzyl-3-methylpyrrolidin-3-yl)amino)-3-...)
Show SMILES C[C@@]1(CCN(Cc2ccccc2)C1)Nc1ccc(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C21H23ClN4O2S2/c1-21(9-10-26(14-21)12-16-5-3-2-4-6-16)24-19-8-7-17(11-18(19)22)30(27,28)25-20-13-29-15-23-20/h2-8,11,13,15,24-25H,9-10,12,14H2,1H3/t21-/m0/s1
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n/an/a 3.09E+3n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373760
PNG
((S)-3-chloro-4-((1-(3-chlorobenzyl)pyrrolidin-3-yl...)
Show SMILES CN([C@H]1CCN(Cc2cccc(Cl)c2)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C21H22Cl2N4O2S2/c1-26(17-7-9-27(14-17)13-15-3-2-4-16(22)11-15)20-6-5-18(12-19(20)23)31(28,29)25-21-24-8-10-30-21/h2-6,8,10-12,17H,7,9,13-14H2,1H3,(H,24,25)/t17-/m0/s1
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n/an/a 3.41E+3n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373992
PNG
((S)-5-chloro-2-fluoro-4-(methyl(1-(1-phenylcyclopr...)
Show SMILES CN([C@H]1CCN(C1)C1(CC1)c1ccccc1)c1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C23H24ClFN4O2S2/c1-28(17-7-10-29(13-17)23(8-9-23)16-5-3-2-4-6-16)20-12-19(25)21(11-18(20)24)33(30,31)27-22-14-32-15-26-22/h2-6,11-12,14-15,17,27H,7-10,13H2,1H3/t17-/m0/s1
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n/an/a 3.52E+3n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM373996
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(ethyl)amino)-5-ch...)
Show SMILES CCN([C@H]1CCN(Cc2ccccc2)C1)c1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C22H24ClFN4O2S2/c1-2-28(17-8-9-27(13-17)12-16-6-4-3-5-7-16)20-11-19(24)21(10-18(20)23)32(29,30)26-22-14-31-15-25-22/h3-7,10-11,14-15,17,26H,2,8-9,12-13H2,1H3/t17-/m0/s1
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n/an/a 3.81E+3n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM373773
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-5-c...)
Show SMILES CN([C@H]1CCN(Cc2ccccc2)C1)c1cc(F)c(cc1Cl)S(=O)(=O)Nc1cccc(F)n1
Show InChI InChI=1S/C23H23ClF2N4O2S/c1-29(17-10-11-30(15-17)14-16-6-3-2-4-7-16)20-13-19(25)21(12-18(20)24)33(31,32)28-23-9-5-8-22(26)27-23/h2-9,12-13,17H,10-11,14-15H2,1H3,(H,27,28)/t17-/m0/s1
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n/an/a 3.88E+3n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373761
PNG
((S)-3-chloro-4-((1-(3-(difluoromethyl)benzyl)pyrro...)
Show SMILES CN([C@H]1CCN(Cc2cccc(c2)C(F)F)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C22H23ClF2N4O2S2/c1-28(17-7-9-29(14-17)13-15-3-2-4-16(11-15)21(24)25)20-6-5-18(12-19(20)23)33(30,31)27-22-26-8-10-32-22/h2-6,8,10-12,17,21H,7,9,13-14H2,1H3,(H,26,27)/t17-/m0/s1
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n/an/a 4.21E+3n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM374049
PNG
((R)-3-chloro-4-((1-(1-(5-chloro-2-fluorophenyl)eth...)
Show SMILES C[C@@H](N1CCC(CC1)Oc1ccc(cc1Cl)S(=O)(=O)Nc1cscn1)c1cc(Cl)ccc1F
Show InChI InChI=1S/C22H22Cl2FN3O3S2/c1-14(18-10-15(23)2-4-20(18)25)28-8-6-16(7-9-28)31-21-5-3-17(11-19(21)24)33(29,30)27-22-12-32-13-26-22/h2-5,10-14,16,27H,6-9H2,1H3/t14-/m1/s1
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n/an/a 4.25E+3n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM373832
PNG
((S)-3-chloro-4-(1-(3,5-dimethylbenzyl)pyrrolidin-3...)
Show SMILES Cc1cc(C)cc(CN2CC[C@@H](C2)Oc2ccc(cc2Cl)S(=O)(=O)Nc2ncns2)c1
Show InChI InChI=1S/C21H23ClN4O3S2/c1-14-7-15(2)9-16(8-14)11-26-6-5-17(12-26)29-20-4-3-18(10-19(20)22)31(27,28)25-21-23-13-24-30-21/h3-4,7-10,13,17H,5-6,11-12H2,1-2H3,(H,23,24,25)/t17-/m0/s1
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n/an/a 4.44E+3n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373986
PNG
((S)-3-chloro-4-((1-(3-(difluoromethyl)benzyl)pyrro...)
Show SMILES CN([C@H]1CCN(Cc2cccc(c2)C(F)F)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C22H23ClF2N4O2S2/c1-28(17-7-8-29(12-17)11-15-3-2-4-16(9-15)22(24)25)20-6-5-18(10-19(20)23)33(30,31)27-21-13-32-14-26-21/h2-6,9-10,13-14,17,22,27H,7-8,11-12H2,1H3/t17-/m0/s1
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n/an/a 4.76E+3n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM373958
PNG
((R)-4-((1-benzyl-3-methylpyrrolidin-3-yl)amino)-3-...)
Show SMILES C[C@]1(CCN(Cc2ccccc2)C1)Nc1ccc(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C21H23ClN4O2S2/c1-21(9-10-26(14-21)12-16-5-3-2-4-6-16)24-19-8-7-17(11-18(19)22)30(27,28)25-20-13-29-15-23-20/h2-8,11,13,15,24-25H,9-10,12,14H2,1H3/t21-/m1/s1
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n/an/a 5.31E+3n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM373810
PNG
(4-((1-benzylpiperidin-4-yl)oxy)-3-chloro-N-(6-fluo...)
Show SMILES Fc1cccc(NS(=O)(=O)c2ccc(OC3CCN(Cc4ccccc4)CC3)c(Cl)c2)n1
Show InChI InChI=1S/C23H23ClFN3O3S/c24-20-15-19(32(29,30)27-23-8-4-7-22(25)26-23)9-10-21(20)31-18-11-13-28(14-12-18)16-17-5-2-1-3-6-17/h1-10,15,18H,11-14,16H2,(H,26,27)
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n/an/a 5.57E+3n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 alpha subunit


(Homo sapiens (Human))
BDBM374038
PNG
((R)-3-chloro-N-(isoxazol-3-yl)-4-((1-(1-phenylethy...)
Show SMILES C[C@@H](N1CCC(CC1)Oc1ccc(cc1Cl)S(=O)(=O)Nc1ccon1)c1ccccc1
Show InChI InChI=1S/C22H24ClN3O4S/c1-16(17-5-3-2-4-6-17)26-12-9-18(10-13-26)30-21-8-7-19(15-20(21)23)31(27,28)25-22-11-14-29-24-22/h2-8,11,14-16,18H,9-10,12-13H2,1H3,(H,24,25)/t16-/m1/s1
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n/an/a 5.57E+3n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373795
PNG
((S)-3-chloro-4-(methyl(1-(2-phenylpropan-2-yl)pyrr...)
Show SMILES CN([C@H]1CCN(C1)C(C)(C)c1ccccc1)c1ccc(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C23H27ClN4O2S2/c1-23(2,17-7-5-4-6-8-17)28-12-11-18(14-28)27(3)21-10-9-19(13-20(21)24)32(29,30)26-22-15-31-16-25-22/h4-10,13,15-16,18,26H,11-12,14H2,1-3H3/t18-/m0/s1
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n/an/a 6.55E+3n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373744
PNG
(3-chloro-4-((1-(3-(difluoromethyl)benzyl)piperidin...)
Show SMILES FC(F)c1cccc(CN2CCC(CC2)Oc2ccc(cc2Cl)S(=O)(=O)Nc2nccs2)c1
Show InChI InChI=1S/C22H22ClF2N3O3S2/c23-19-13-18(33(29,30)27-22-26-8-11-32-22)4-5-20(19)31-17-6-9-28(10-7-17)14-15-2-1-3-16(12-15)21(24)25/h1-5,8,11-13,17,21H,6-7,9-10,14H2,(H,26,27)
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n/an/a 7.21E+3n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373820
PNG
((S)-4-(1-benzylpyrrolidin-3-ylamino)-5-chloro-2-fl...)
Show SMILES Fc1cc(N[C@H]2CCN(Cc3ccccc3)C2)c(Cl)cc1S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C20H20ClFN4O2S2/c21-16-10-19(30(27,28)25-20-23-7-9-29-20)17(22)11-18(16)24-15-6-8-26(13-15)12-14-4-2-1-3-5-14/h1-5,7,9-11,15,24H,6,8,12-13H2,(H,23,25)/t15-/m0/s1
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n/an/a 7.28E+3n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373825
PNG
(3-chloro-4-(1-(3-methylbenzyl)piperidin-4-yloxy)-N...)
Show SMILES Cc1cccc(CN2CCC(CC2)Oc2ccc(cc2Cl)S(=O)(=O)Nc2nccs2)c1
Show InChI InChI=1S/C22H24ClN3O3S2/c1-16-3-2-4-17(13-16)15-26-10-7-18(8-11-26)29-21-6-5-19(14-20(21)23)31(27,28)25-22-24-9-12-30-22/h2-6,9,12-14,18H,7-8,10-11,15H2,1H3,(H,24,25)
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n/an/a 7.53E+3n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM444497
PNG
((S)-3-chloro-4-((1-(1-phenylethyl)piperidin-4-yl)o...)
Show SMILES C[C@H](N1CCC(CC1)Oc1ccc(cc1Cl)S(=O)(=O)Nc1nccs1)c1ccccc1
Show InChI InChI=1S/C22H24ClN3O3S2/c1-16(17-5-3-2-4-6-17)26-12-9-18(10-13-26)29-21-8-7-19(15-20(21)23)31(27,28)25-22-24-11-14-30-22/h2-8,11,14-16,18H,9-10,12-13H2,1H3,(H,24,25)/t16-/m0/s1
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n/an/a 9.15E+3n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373993
PNG
((S)-5-chloro-2-fluoro-N-(6-fluoropyridin-2-yl)-4-(...)
Show SMILES CN([C@H]1CCN(C1)C(C)(C)c1ccccc1)c1cc(F)c(cc1Cl)S(=O)(=O)Nc1cccc(F)n1
Show InChI InChI=1S/C25H27ClF2N4O2S/c1-25(2,17-8-5-4-6-9-17)32-13-12-18(16-32)31(3)21-15-20(27)22(14-19(21)26)35(33,34)30-24-11-7-10-23(28)29-24/h4-11,14-15,18H,12-13,16H2,1-3H3,(H,29,30)/t18-/m0/s1
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n/an/a 9.64E+3n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373792
PNG
(3-chloro-4-((1-(2-phenylpropan-2-yl)piperidin-4-yl...)
Show SMILES CC(C)(N1CCC(CC1)Oc1ccc(cc1Cl)S(=O)(=O)Nc1nccs1)c1ccccc1
Show InChI InChI=1S/C23H26ClN3O3S2/c1-23(2,17-6-4-3-5-7-17)27-13-10-18(11-14-27)30-21-9-8-19(16-20(21)24)32(28,29)26-22-25-12-15-31-22/h3-9,12,15-16,18H,10-11,13-14H2,1-2H3,(H,25,26)
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n/an/a 9.91E+3n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM444511
PNG
((S)-3-chloro-4-(methyl(1-(3- methylbenzyl)pyrrolid...)
Show SMILES Cc1cccc(CN2CC[C@@H](C2)Nc2ccc(cc2Cl)S(=O)(=O)Nc2ncns2)c1
Show InChI InChI=1S/C20H22ClN5O2S2/c1-14-3-2-4-15(9-14)11-26-8-7-16(12-26)24-19-6-5-17(10-18(19)21)30(27,28)25-20-22-13-23-29-20/h2-6,9-10,13,16,24H,7-8,11-12H2,1H3,(H,22,23,25)/t16-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373926
PNG
((S)-5-chloro-4-((1-(3-(difluoromethyl)benzyl)-pyrr...)
Show SMILES CN([C@H]1CCN(Cc2cccc(c2)C(F)F)C1)c1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C22H22ClF3N4O2S2/c1-29(16-5-6-30(11-16)10-14-3-2-4-15(7-14)22(25)26)19-9-18(24)20(8-17(19)23)34(31,32)28-21-12-33-13-27-21/h2-4,7-9,12-13,16,22,28H,5-6,10-11H2,1H3/t16-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373979
PNG
(5-chloro-4-(((S)-1-((R)-2,3-dihydro-1H-inden-1-yl)...)
Show SMILES CN([C@H]1CCN(C1)[C@@H]1CCc2ccccc12)c1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C23H24ClFN4O2S2/c1-28(16-8-9-29(12-16)20-7-6-15-4-2-3-5-17(15)20)21-11-19(25)22(10-18(21)24)33(30,31)27-23-13-32-14-26-23/h2-5,10-11,13-14,16,20,27H,6-9,12H2,1H3/t16-,20+/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM444536
PNG
(5-chloro-4-(((S)-1-((S)-2,3-dihydro-1H-inden-1-yl)...)
Show SMILES CN([C@H]1CCN(C1)C1CCc2ccccc12)c1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C23H24ClFN4O2S2/c1-28(16-8-9-29(12-16)20-7-6-15-4-2-3-5-17(15)20)21-11-19(25)22(10-18(21)24)33(30,31)27-23-13-32-14-26-23/h2-5,10-11,13-14,16,20,27H,6-9,12H2,1H3/t16-,20?/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373749
PNG
(4-(((1R,3s,5S)-8-benzyl-8-azabicyclo[3.2.1]octan-3...)
Show SMILES Clc1cc(ccc1O[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccccc1)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C23H24ClN3O3S2/c24-21-14-20(32(28,29)26-23-25-10-11-31-23)8-9-22(21)30-19-12-17-6-7-18(13-19)27(17)15-16-4-2-1-3-5-16/h1-5,8-11,14,17-19H,6-7,12-13,15H2,(H,25,26)/t17-,18+,19-
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n/an/a>1.00E+4n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373750
PNG
(4-(((1R,3s,5S)-8-benzyl-8-azabicyclo[3.2.1]octan-3...)
Show SMILES Fc1cc(O[C@H]2C[C@@H]3CC[C@H](C2)N3Cc2ccccc2)c(Cl)cc1S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C23H23ClFN3O3S2/c24-19-12-22(33(29,30)27-23-26-8-9-32-23)20(25)13-21(19)31-18-10-16-6-7-17(11-18)28(16)14-15-4-2-1-3-5-15/h1-5,8-9,12-13,16-18H,6-7,10-11,14H2,(H,26,27)/t16-,17+,18-
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373766
PNG
((S)-3-chloro-4-((1-(5-chloro-2-fluorobenzyl)pyrrol...)
Show SMILES CN([C@H]1CCN(Cc2cc(Cl)ccc2F)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H20Cl2FN5O2S2/c1-27(15-6-7-28(11-15)10-13-8-14(21)2-4-18(13)23)19-5-3-16(9-17(19)22)32(29,30)26-20-24-12-25-31-20/h2-5,8-9,12,15H,6-7,10-11H2,1H3,(H,24,25,26)/t15-/m0/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373769
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(ethyl)amino)-3-ch...)
Show SMILES CCN([C@H]1CCN(Cc2ccccc2)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C21H24ClN5O2S2/c1-2-27(17-10-11-26(14-17)13-16-6-4-3-5-7-16)20-9-8-18(12-19(20)22)31(28,29)25-21-23-15-24-30-21/h3-9,12,15,17H,2,10-11,13-14H2,1H3,(H,23,24,25)/t17-/m0/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373798
PNG
(3-chloro-4-((1-(pyridin-2-ylmethyl)piperidin-4-yl)...)
Show SMILES Clc1cc(ccc1OC1CCN(Cc2ccccn2)CC1)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C20H21ClN4O3S2/c21-18-13-17(30(26,27)24-20-23-9-12-29-20)4-5-19(18)28-16-6-10-25(11-7-16)14-15-3-1-2-8-22-15/h1-5,8-9,12-13,16H,6-7,10-11,14H2,(H,23,24)
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373801
PNG
((R)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-3-c...)
Show SMILES CN([C@@H]1CCN(Cc2ccccc2)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H22ClN5O2S2/c1-25(16-9-10-26(13-16)12-15-5-3-2-4-6-15)19-8-7-17(11-18(19)21)30(27,28)24-20-22-14-23-29-20/h2-8,11,14,16H,9-10,12-13H2,1H3,(H,22,23,24)/t16-/m1/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM444527
PNG
((S)-5-chloro-2-fluoro-4- (methyl(1-((6-methylpyrid...)
Show SMILES C[C@@]1(CCN(Cc2ccccc2)C1)Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C21H22ClFN4O2S2/c1-21(7-8-27(13-21)11-15-5-3-2-4-6-15)25-18-10-17(23)19(9-16(18)22)31(28,29)26-20-12-30-14-24-20/h2-6,9-10,12,14,25-26H,7-8,11,13H2,1H3/t21-/m0/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373939
PNG
((S)-5-chloro-2-fluoro-4-((1-(2-methoxybenzyl)pyrro...)
Show SMILES COc1ccccc1CN1CC[C@@H](C1)N(C)c1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C22H24ClFN4O3S2/c1-27(16-7-8-28(12-16)11-15-5-3-4-6-20(15)31-2)19-10-18(24)21(9-17(19)23)33(29,30)26-22-13-32-14-25-22/h3-6,9-10,13-14,16,26H,7-8,11-12H2,1-2H3/t16-/m0/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373984
PNG
(3-chloro-4-(methyl((S)-1-((R)-1-phenylethyl)pyrrol...)
Show SMILES C[C@@H](N1CC[C@@H](C1)N(C)c1ccc(cc1Cl)S(=O)(=O)Nc1cscn1)c1ccccc1
Show InChI InChI=1S/C22H25ClN4O2S2/c1-16(17-6-4-3-5-7-17)27-11-10-18(13-27)26(2)21-9-8-19(12-20(21)23)31(28,29)25-22-14-30-15-24-22/h3-9,12,14-16,18,25H,10-11,13H2,1-2H3/t16-,18+/m1/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM373762
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-3-c...)
Show SMILES CN([C@H]1CCN(Cc2ccccc2)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H22ClN5O2S2/c1-25(16-9-10-26(13-16)12-15-5-3-2-4-6-15)19-8-7-17(11-18(19)21)30(27,28)24-20-22-14-23-29-20/h2-8,11,14,16H,9-10,12-13H2,1H3,(H,22,23,24)/t16-/m0/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373774
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-3-c...)
Show SMILES CN([C@H]1CCN(Cc2ccccc2)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C21H23ClN4O2S2/c1-25(17-9-10-26(13-17)12-16-5-3-2-4-6-16)20-8-7-18(11-19(20)22)30(27,28)24-21-14-29-15-23-21/h2-8,11,14-15,17,24H,9-10,12-13H2,1H3/t17-/m0/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373794
PNG
(4-((1-benzyl-3-methylpyrrolidin-3-yl)amino)-3-chlo...)
Show SMILES CC1(CCN(Cc2ccccc2)C1)Nc1ccc(cc1Cl)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C21H23ClN4O2S2/c1-21(9-11-26(15-21)14-16-5-3-2-4-6-16)24-19-8-7-17(13-18(19)22)30(27,28)25-20-23-10-12-29-20/h2-8,10,12-13,24H,9,11,14-15H2,1H3,(H,23,25)
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373833
PNG
(4-(1-benzylpiperidin-4-yloxy)-3-chloro-N-(1,2,4-th...)
Show SMILES Clc1cc(ccc1OC1CCN(Cc2ccccc2)CC1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H21ClN4O3S2/c21-18-12-17(30(26,27)24-20-22-14-23-29-20)6-7-19(18)28-16-8-10-25(11-9-16)13-15-4-2-1-3-5-15/h1-7,12,14,16H,8-11,13H2,(H,22,23,24)
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373839
PNG
(4-((1-benzylpiperidin-4-yl)oxy)-2,6-difluoro-3-met...)
Show SMILES Cc1c(F)c(c(F)cc1OC1CCN(Cc2ccccc2)CC1)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C22H23F2N3O3S2/c1-15-19(30-17-7-9-27(10-8-17)12-16-5-3-2-4-6-16)11-18(23)22(21(15)24)32(28,29)26-20-13-31-14-25-20/h2-6,11,13-14,17,26H,7-10,12H2,1H3
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM374012
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...)
Show SMILES CN([C@H]1CCN(Cc2ccccc2)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1ccsn1
Show InChI InChI=1S/C22H24F2N4O2S2/c1-15-19(27(2)17-8-10-28(14-17)13-16-6-4-3-5-7-16)12-18(23)22(21(15)24)32(29,30)26-20-9-11-31-25-20/h3-7,9,11-12,17H,8,10,13-14H2,1-2H3,(H,25,26)/t17-/m0/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373990
PNG
((S)-5-chloro-2-fluoro-4-(methyl(1-(2-phenylpropan-...)
Show SMILES CN([C@H]1CCN(C1)C(C)(C)c1ccccc1)c1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C23H26ClFN4O2S2/c1-23(2,16-7-5-4-6-8-16)29-10-9-17(13-29)28(3)20-12-19(25)21(11-18(20)24)33(30,31)27-22-14-32-15-26-22/h4-8,11-12,14-15,17,27H,9-10,13H2,1-3H3/t17-/m0/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM374052
PNG
(4-(((1R,3s,5S)-8-benzyl-8-azabicyclo[3.2.1]octan-3...)
Show SMILES Clc1cc(ccc1O[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccccc1)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C23H24ClN3O3S2/c24-21-12-20(32(28,29)26-23-14-31-15-25-23)8-9-22(21)30-19-10-17-6-7-18(11-19)27(17)13-16-4-2-1-3-5-16/h1-5,8-9,12,14-15,17-19,26H,6-7,10-11,13H2/t17-,18+,19-
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373777
PNG
(3-chloro-4-(methyl((S)-1-((R)-1-phenylethyl)pyrrol...)
Show SMILES C[C@@H](N1CC[C@@H](C1)N(C)c1ccc(cc1Cl)S(=O)(=O)Nc1nccs1)c1ccccc1
Show InChI InChI=1S/C22H25ClN4O2S2/c1-16(17-6-4-3-5-7-17)27-12-10-18(15-27)26(2)21-9-8-19(14-20(21)23)31(28,29)25-22-24-11-13-30-22/h3-9,11,13-14,16,18H,10,12,15H2,1-2H3,(H,24,25)/t16-,18+/m1/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM444508
PNG
((R)-4-(1-benzylpyrrolidin-3-ylamino)-3-chloro- N-(...)
Show SMILES Clc1cc(ccc1N[C@@H]1CCN(C1)c1ccccc1)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C19H19ClN4O2S2/c20-17-12-16(28(25,26)23-19-21-9-11-27-19)6-7-18(17)22-14-8-10-24(13-14)15-4-2-1-3-5-15/h1-7,9,11-12,14,22H,8,10,13H2,(H,21,23)/t14-/m1/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373773
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-5-c...)
Show SMILES CN([C@H]1CCN(Cc2ccccc2)C1)c1cc(F)c(cc1Cl)S(=O)(=O)Nc1cccc(F)n1
Show InChI InChI=1S/C23H23ClF2N4O2S/c1-29(17-10-11-30(15-17)14-16-6-3-2-4-7-16)20-13-19(25)21(12-18(20)24)33(31,32)28-23-9-5-8-22(26)27-23/h2-9,12-13,17H,10-11,14-15H2,1H3,(H,27,28)/t17-/m0/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM374016
PNG
((R)-2,6-difluoro-3-methyl-4-((1-(1-phenylethyl)pip...)
Show SMILES C[C@@H](N1CCC(CC1)Oc1cc(F)c(c(F)c1Cl)S(=O)(=O)Nc1cscn1)c1ccccc1
Show InChI InChI=1S/C22H22ClF2N3O3S2/c1-14(15-5-3-2-4-6-15)28-9-7-16(8-10-28)31-18-11-17(24)22(21(25)20(18)23)33(29,30)27-19-12-32-13-26-19/h2-6,11-14,16,27H,7-10H2,1H3/t14-/m1/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373975
PNG
(5-chloro-2-fluoro-4-(methyl((S)-1-((S)-1-phenylpro...)
Show SMILES CC[C@H](N1CC[C@@H](C1)N(C)c1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1)c1ccccc1
Show InChI InChI=1S/C23H26ClFN4O2S2/c1-3-20(16-7-5-4-6-8-16)29-10-9-17(13-29)28(2)21-12-19(25)22(11-18(21)24)33(30,31)27-23-14-32-15-26-23/h4-8,11-12,14-15,17,20,27H,3,9-10,13H2,1-2H3/t17-,20-/m0/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM374033
PNG
((R)-3-chloro-4-((1-(1-phenylethyl)piperidin-4-yl)o...)
Show SMILES C[C@@H](N1CCC(CC1)Oc1ccc(cc1Cl)S(=O)(=O)Nc1ccncn1)c1ccccc1
Show InChI InChI=1S/C23H25ClN4O3S/c1-17(18-5-3-2-4-6-18)28-13-10-19(11-14-28)31-22-8-7-20(15-21(22)24)32(29,30)27-23-9-12-25-16-26-23/h2-9,12,15-17,19H,10-11,13-14H2,1H3,(H,25,26,27)/t17-/m1/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373788
PNG
((R)-3-chloro-4-((1-(1-phenylethyl)piperidin-4-yl)o...)
Show SMILES C[C@@H](N1CCC(CC1)Oc1ccc(cc1Cl)S(=O)(=O)Nc1nccs1)c1ccccc1
Show InChI InChI=1S/C22H24ClN3O3S2/c1-16(17-5-3-2-4-6-17)26-12-9-18(10-13-26)29-21-8-7-19(15-20(21)23)31(27,28)25-22-24-11-14-30-22/h2-8,11,14-16,18H,9-10,12-13H2,1H3,(H,24,25)/t16-/m1/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373790
PNG
((R)-3-chloro-4-((1-(1-phenylethyl)piperidin-4-yl)o...)
Show SMILES C[C@@H](N1CCC(CC1)Oc1ccc(cc1Cl)S(=O)(=O)Nc1cscn1)c1ccccc1
Show InChI InChI=1S/C22H24ClN3O3S2/c1-16(17-5-3-2-4-6-17)26-11-9-18(10-12-26)29-21-8-7-19(13-20(21)23)31(27,28)25-22-14-30-15-24-22/h2-8,13-16,18,25H,9-12H2,1H3/t16-/m1/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM374031
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...)
Show SMILES CN([C@H]1CCN(Cc2ccccc2)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1cccc(F)n1
Show InChI InChI=1S/C24H25F3N4O2S/c1-16-20(30(2)18-11-12-31(15-18)14-17-7-4-3-5-8-17)13-19(25)24(23(16)27)34(32,33)29-22-10-6-9-21(26)28-22/h3-10,13,18H,11-12,14-15H2,1-2H3,(H,28,29)/t18-/m0/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373955
PNG
((R)-5-chloro-2-fluoro-4-((1-(1-phenylethyl)piperid...)
Show SMILES C[C@@H](N1CCC(CC1)Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1)c1ccccc1
Show InChI InChI=1S/C22H23ClFN3O3S2/c1-15(16-5-3-2-4-6-16)27-9-7-17(8-10-27)30-20-12-19(24)21(11-18(20)23)32(28,29)26-22-13-31-14-25-22/h2-6,11-15,17,26H,7-10H2,1H3/t15-/m1/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373771
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-5-c...)
Show SMILES CN([C@H]1CCN(Cc2ccccc2)C1)c1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C21H22ClFN4O2S2/c1-26(16-7-8-27(12-16)11-15-5-3-2-4-6-15)19-10-18(23)20(9-17(19)22)31(28,29)25-21-13-30-14-24-21/h2-6,9-10,13-14,16,25H,7-8,11-12H2,1H3/t16-/m0/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM374031
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...)
Show SMILES CN([C@H]1CCN(Cc2ccccc2)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1cccc(F)n1
Show InChI InChI=1S/C24H25F3N4O2S/c1-16-20(30(2)18-11-12-31(15-18)14-17-7-4-3-5-8-17)13-19(25)24(23(16)27)34(32,33)29-22-10-6-9-21(26)28-22/h3-10,13,18H,11-12,14-15H2,1-2H3,(H,28,29)/t18-/m0/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373835
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-3-c...)
Show SMILES CN(C1CCN(Cc2ccccc2)C1)c1cc(F)c(c(F)c1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C21H21ClF2N4O2S2/c1-27(15-7-8-28(11-15)10-14-5-3-2-4-6-14)17-9-16(23)21(20(24)19(17)22)32(29,30)26-18-12-31-13-25-18/h2-6,9,12-13,15,26H,7-8,10-11H2,1H3
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM373836
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...)
Show SMILES CN(C1CCN(Cc2ccccc2)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C22H24F2N4O2S2/c1-15-19(27(2)17-8-9-28(12-17)11-16-6-4-3-5-7-16)10-18(23)22(21(15)24)32(29,30)26-20-13-31-14-25-20/h3-7,10,13-14,17,26H,8-9,11-12H2,1-2H3
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373837
PNG
((S)-2,6-difluoro-3-methyl-4-(methyl(1-((6-methylpy...)
Show SMILES CN(C1CCN(Cc2cccc(C)n2)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C22H25F2N5O2S2/c1-14-5-4-6-16(26-14)10-29-8-7-17(11-29)28(3)19-9-18(23)22(21(24)15(19)2)33(30,31)27-20-12-32-13-25-20/h4-6,9,12-13,17,27H,7-8,10-11H2,1-3H3
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373954
PNG
((S)-3-chloro-4-((1-(1-phenylethyl)piperidin-4-yl)o...)
Show SMILES C[C@H](N1CCC(CC1)Oc1ccc(cc1Cl)S(=O)(=O)Nc1ncns1)c1ccccc1
Show InChI InChI=1S/C21H23ClN4O3S2/c1-15(16-5-3-2-4-6-16)26-11-9-17(10-12-26)29-20-8-7-18(13-19(20)22)31(27,28)25-21-23-14-24-30-21/h2-8,13-15,17H,9-12H2,1H3,(H,23,24,25)/t15-/m0/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373959
PNG
((S)-4-((1-benzyl-3-methylpyrrolidin-3-yl)amino)-3-...)
Show SMILES C[C@@]1(CCN(Cc2ccccc2)C1)Nc1ccc(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C21H23ClN4O2S2/c1-21(9-10-26(14-21)12-16-5-3-2-4-6-16)24-19-8-7-17(11-18(19)22)30(27,28)25-20-13-29-15-23-20/h2-8,11,13,15,24-25H,9-10,12,14H2,1H3/t21-/m0/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373996
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(ethyl)amino)-5-ch...)
Show SMILES CCN([C@H]1CCN(Cc2ccccc2)C1)c1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C22H24ClFN4O2S2/c1-2-28(17-8-9-27(13-17)12-16-6-4-3-5-7-16)20-11-19(24)21(10-18(20)23)32(29,30)26-22-14-31-15-25-22/h3-7,10-11,14-15,17,26H,2,8-9,12-13H2,1H3/t17-/m0/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM374002
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)oxy)-2,6-difluoro-...)
Show SMILES Cc1c(F)c(c(F)cc1O[C@H]1CCN(Cc2ccccc2)C1)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C21H21F2N3O3S2/c1-14-18(29-16-7-8-26(11-16)10-15-5-3-2-4-6-15)9-17(22)21(20(14)23)31(27,28)25-19-12-30-13-24-19/h2-6,9,12-13,16,25H,7-8,10-11H2,1H3/t16-/m0/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM374038
PNG
((R)-3-chloro-N-(isoxazol-3-yl)-4-((1-(1-phenylethy...)
Show SMILES C[C@@H](N1CCC(CC1)Oc1ccc(cc1Cl)S(=O)(=O)Nc1ccon1)c1ccccc1
Show InChI InChI=1S/C22H24ClN3O4S/c1-16(17-5-3-2-4-6-17)26-12-9-18(10-13-26)30-21-8-7-19(15-20(21)23)31(27,28)25-22-11-14-29-24-22/h2-8,11,14-16,18H,9-10,12-13H2,1H3,(H,24,25)/t16-/m1/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM374055
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2-f...)
Show SMILES CN([C@H]1CCN(Cc2ccccc2)C1)c1ccc(c(F)c1C)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C22H25FN4O2S2/c1-16-19(8-9-20(22(16)23)31(28,29)25-21-14-30-15-24-21)26(2)18-10-11-27(13-18)12-17-6-4-3-5-7-17/h3-9,14-15,18,25H,10-13H2,1-2H3/t18-/m0/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373758
PNG
(4-((1-benzyl-3-methylazetidin-3-yl)amino)-3-chloro...)
Show SMILES CC1(CN(Cc2ccccc2)C1)Nc1ccc(cc1Cl)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C20H21ClN4O2S2/c1-20(13-25(14-20)12-15-5-3-2-4-6-15)23-18-8-7-16(11-17(18)21)29(26,27)24-19-22-9-10-28-19/h2-11,23H,12-14H2,1H3,(H,22,24)
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373762
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-3-c...)
Show SMILES CN([C@H]1CCN(Cc2ccccc2)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H22ClN5O2S2/c1-25(16-9-10-26(13-16)12-15-5-3-2-4-6-15)19-8-7-17(11-18(19)21)30(27,28)24-20-22-14-23-29-20/h2-8,11,14,16H,9-10,12-13H2,1H3,(H,22,23,24)/t16-/m0/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM444509
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)- 3-...)
Show SMILES CN([C@H]1CCN(C1)c1ccccc1)c1ccc(cc1Cl)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C20H21ClN4O2S2/c1-24(16-9-11-25(14-16)15-5-3-2-4-6-15)19-8-7-17(13-18(19)21)29(26,27)23-20-22-10-12-28-20/h2-8,10,12-13,16H,9,11,14H2,1H3,(H,22,23)/t16-/m0/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373815
PNG
(3-chloro-4-(1-((6-methylpyridin-2-yl)methyl)piperi...)
Show SMILES Cc1cccc(CN2CCC(CC2)Oc2ccc(cc2Cl)S(=O)(=O)Nc2nccs2)n1
Show InChI InChI=1S/C21H23ClN4O3S2/c1-15-3-2-4-16(24-15)14-26-10-7-17(8-11-26)29-20-6-5-18(13-19(20)22)31(27,28)25-21-23-9-12-30-21/h2-6,9,12-13,17H,7-8,10-11,14H2,1H3,(H,23,25)
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373838
PNG
(4-((1-benzylpiperidin-4-yl)oxy)-3-chloro-2,6-diflu...)
Show SMILES Fc1cc(OC2CCN(Cc3ccccc3)CC2)c(Cl)c(F)c1S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C21H20ClF2N3O3S2/c22-19-17(30-15-6-8-27(9-7-15)11-14-4-2-1-3-5-14)10-16(23)21(20(19)24)32(28,29)26-18-12-31-13-25-18/h1-5,10,12-13,15,26H,6-9,11H2
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n/an/a>1.00E+4n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373958
PNG
((R)-4-((1-benzyl-3-methylpyrrolidin-3-yl)amino)-3-...)
Show SMILES C[C@]1(CCN(Cc2ccccc2)C1)Nc1ccc(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C21H23ClN4O2S2/c1-21(9-10-26(14-21)12-16-5-3-2-4-6-16)24-19-8-7-17(11-18(19)22)30(27,28)25-20-13-29-15-23-20/h2-8,11,13,15,24-25H,9-10,12,14H2,1H3/t21-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM373987
PNG
((S)-3-chloro-4-((1-(5-chloro-2-fluorobenzyl)pyrrol...)
Show SMILES CN([C@H]1CCN(Cc2cc(Cl)ccc2F)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C21H21Cl2FN4O2S2/c1-27(16-6-7-28(11-16)10-14-8-15(22)2-4-19(14)24)20-5-3-17(9-18(20)23)32(29,30)26-21-12-31-13-25-21/h2-5,8-9,12-13,16,26H,6-7,10-11H2,1H3/t16-/m0/s1
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n/an/a 1.70E+4n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM373771
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-5-c...)
Show SMILES CN([C@H]1CCN(Cc2ccccc2)C1)c1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C21H22ClFN4O2S2/c1-26(16-7-8-27(12-16)11-15-5-3-2-4-6-15)19-10-18(23)20(9-17(19)22)31(28,29)25-21-13-30-14-24-21/h2-6,9-10,13-14,16,25H,7-8,11-12H2,1H3/t16-/m0/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM373834
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2-f...)
Show SMILES CN(C1CCN(Cc2ccccc2)C1)c1cc(F)c(cc1C)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C22H25FN4O2S2/c1-16-10-21(31(28,29)25-22-14-30-15-24-22)19(23)11-20(16)26(2)18-8-9-27(13-18)12-17-6-4-3-5-7-17/h3-7,10-11,14-15,18,25H,8-9,12-13H2,1-2H3
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n/an/a>3.00E+4n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373834
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2-f...)
Show SMILES CN(C1CCN(Cc2ccccc2)C1)c1cc(F)c(cc1C)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C22H25FN4O2S2/c1-16-10-21(31(28,29)25-22-14-30-15-24-22)19(23)11-20(16)26(2)18-8-9-27(13-18)12-17-6-4-3-5-7-17/h3-7,10-11,14-15,18,25H,8-9,12-13H2,1-2H3
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n/an/a 3.17E+4n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373836
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...)
Show SMILES CN(C1CCN(Cc2ccccc2)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C22H24F2N4O2S2/c1-15-19(27(2)17-8-9-28(12-17)11-16-6-4-3-5-7-16)10-18(23)22(21(15)24)32(29,30)26-20-13-31-14-25-20/h3-7,10,13-14,17,26H,8-9,11-12H2,1-2H3
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n/an/a 4.09E+4n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US10662184 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%