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Patent code US10662186

Compile Data Set for Download or QSAR

Found 650 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM444593
PNG
(US10662186, Compound 129)
Show SMILES Cc1nc2c(F)cc(cc2n1C(C)(C)C)-c1nc(Nc2ccc3CN(C[C@@H]4CNCCO4)CCc3n2)ncc1F
Show InChI InChI=1S/C29H34F2N8O/c1-17-34-27-21(30)11-19(12-24(27)39(17)29(2,3)4)26-22(31)14-33-28(37-26)36-25-6-5-18-15-38(9-7-23(18)35-25)16-20-13-32-8-10-40-20/h5-6,11-12,14,20,32H,7-10,13,15-16H2,1-4H3,(H,33,35,36,37)/t20-/m0/s1
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n/an/a 0.700n/an/an/an/an/an/a



SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...


US Patent US10662186 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (Human))
BDBM444596
PNG
(US10662186, Compound 132)
Show SMILES CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCNC(N)=N)CCc3n2)ncc1F
Show InChI InChI=1S/C26H30F2N10/c1-14(2)38-15(3)33-24-18(27)10-17(11-21(24)38)23-19(28)12-32-26(36-23)35-22-5-4-16-13-37(8-6-20(16)34-22)9-7-31-25(29)30/h4-5,10-12,14H,6-9,13H2,1-3H3,(H4,29,30,31)(H,32,34,35,36)
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n/an/a 0.770n/an/an/an/an/an/a



SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...


US Patent US10662186 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM444563
PNG
(US10662186, Compound 82)
Show SMILES CCC(CC)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CNCCc3n2)ncc1F
Show InChI InChI=1S/C25H27F2N7/c1-4-17(5-2)34-14(3)30-24-18(26)10-16(11-21(24)34)23-19(27)13-29-25(33-23)32-22-7-6-15-12-28-9-8-20(15)31-22/h6-7,10-11,13,17,28H,4-5,8-9,12H2,1-3H3,(H,29,31,32,33)
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n/an/a 0.860n/an/an/an/an/an/a



SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...


US Patent US10662186 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM444595
PNG
(US10662186, Compound 131)
Show SMILES CN1CCC[C@H]1CN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1
Show InChI InChI=1S/C29H32F2N8/c1-17-33-28-22(30)12-19(13-25(28)39(17)20-6-7-20)27-23(31)14-32-29(36-27)35-26-8-5-18-15-38(11-9-24(18)34-26)16-21-4-3-10-37(21)2/h5,8,12-14,20-21H,3-4,6-7,9-11,15-16H2,1-2H3,(H,32,34,35,36)/t21-/m0/s1
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n/an/a 0.910n/an/an/an/an/an/a



SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...


US Patent US10662186 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM444569
PNG
(US10662186, Compound 88)
Show SMILES CN(C)CCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C3(C)CC3)ccc2C1
Show InChI InChI=1S/C28H32F2N8/c1-17-32-26-20(29)13-19(14-23(26)38(17)28(2)8-9-28)25-21(30)15-31-27(35-25)34-24-6-5-18-16-37(12-11-36(3)4)10-7-22(18)33-24/h5-6,13-15H,7-12,16H2,1-4H3,(H,31,33,34,35)
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n/an/a 0.910n/an/an/an/an/an/a



SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...


US Patent US10662186 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM444568
PNG
(US10662186, Compound 87)
Show SMILES Cc1nc2c(F)cc(cc2n1C1(C)CC1)-c1nc(Nc2ccc3CNCCc3n2)ncc1F
Show InChI InChI=1S/C24H23F2N7/c1-13-29-22-16(25)9-15(10-19(22)33(13)24(2)6-7-24)21-17(26)12-28-23(32-21)31-20-4-3-14-11-27-8-5-18(14)30-20/h3-4,9-10,12,27H,5-8,11H2,1-2H3,(H,28,30,31,32)
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n/an/a 0.920n/an/an/an/an/an/a



SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...


US Patent US10662186 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 9


(Homo sapiens (Human))
BDBM444516
PNG
(US10662186, Compound 38)
Show SMILES CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)C=C)ncc1F
Show InChI InChI=1S/C26H25F2N7O/c1-5-23(36)34-9-8-20-16(13-34)6-7-22(31-20)32-26-29-12-19(28)24(33-26)17-10-18(27)25-21(11-17)35(14(2)3)15(4)30-25/h5-7,10-12,14H,1,8-9,13H2,2-4H3,(H,29,31,32,33)
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SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...


US Patent US10662186 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM444566
PNG
(US10662186, Compound 85)
Show SMILES C[C@@H](CN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1)N(C)C
Show InChI InChI=1S/C28H32F2N8/c1-16(36(3)4)14-37-10-9-23-18(15-37)5-8-25(33-23)34-28-31-13-22(30)26(35-28)19-11-21(29)27-24(12-19)38(17(2)32-27)20-6-7-20/h5,8,11-13,16,20H,6-7,9-10,14-15H2,1-4H3,(H,31,33,34,35)/t16-/m0/s1
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SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...


US Patent US10662186 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM444574
PNG
(US10662186, Compound 93)
Show SMILES CN1CCO[C@@H](CN2CCc3nc(Nc4ncc(F)c(n4)-c4cc(F)c5nc(C)n(c5c4)C(C)(C)C)ccc3C2)C1
Show InChI InChI=1S/C30H36F2N8O/c1-18-34-28-22(31)12-20(13-25(28)40(18)30(2,3)4)27-23(32)14-33-29(37-27)36-26-7-6-19-15-39(9-8-24(19)35-26)17-21-16-38(5)10-11-41-21/h6-7,12-14,21H,8-11,15-17H2,1-5H3,(H,33,35,36,37)/t21-/m1/s1
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SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...


US Patent US10662186 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM444567
PNG
(US10662186, Compound 86)
Show SMILES CC(C1CC1)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCN(C)C)CCc3n2)ncc1F
Show InChI InChI=1S/C29H34F2N8/c1-17(19-5-6-19)39-18(2)33-28-22(30)13-21(14-25(28)39)27-23(31)15-32-29(36-27)35-26-8-7-20-16-38(12-11-37(3)4)10-9-24(20)34-26/h7-8,13-15,17,19H,5-6,9-12,16H2,1-4H3,(H,32,34,35,36)
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SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...


US Patent US10662186 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (Human))
BDBM444581
PNG
(US10662186, Compound 103 | US10662186, Compound 10...)
Show SMILES C[C@@H]1N(CCN(C)C)CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc12
Show InChI InChI=1S/C29H36F2N8/c1-17-20-8-9-25(34-23(20)10-11-38(17)13-12-37(6)7)35-28-32-16-22(31)26(36-28)19-14-21(30)27-24(15-19)39(18(2)33-27)29(3,4)5/h8-9,14-17H,10-13H2,1-7H3,(H,32,34,35,36)/t17-/m0/s1
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SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...


US Patent US10662186 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM444573
PNG
(US10662186, Compound 92)
Show SMILES CN(C)CCC(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc2C1
Show InChI InChI=1S/C29H34F2N8O/c1-17-33-27-20(30)13-19(14-23(27)39(17)29(2,3)4)26-21(31)15-32-28(36-26)35-24-8-7-18-16-38(12-9-22(18)34-24)25(40)10-11-37(5)6/h7-8,13-15H,9-12,16H2,1-6H3,(H,32,34,35,36)
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SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...


US Patent US10662186 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM444596
PNG
(US10662186, Compound 132)
Show SMILES CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCNC(N)=N)CCc3n2)ncc1F
Show InChI InChI=1S/C26H30F2N10/c1-14(2)38-15(3)33-24-18(27)10-17(11-21(24)38)23-19(28)12-32-26(36-23)35-22-5-4-16-13-37(8-6-20(16)34-22)9-7-31-25(29)30/h4-5,10-12,14H,6-9,13H2,1-3H3,(H4,29,30,31)(H,32,34,35,36)
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SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...


US Patent US10662186 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM444572
PNG
(US10662186, Compound 91)
Show SMILES CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCN(C)C(N)=N)CCc3n2)ncc1F
Show InChI InChI=1S/C27H32F2N10/c1-15(2)39-16(3)33-25-19(28)11-18(12-22(25)39)24-20(29)13-32-27(36-24)35-23-6-5-17-14-38(8-7-21(17)34-23)10-9-37(4)26(30)31/h5-6,11-13,15H,7-10,14H2,1-4H3,(H3,30,31)(H,32,34,35,36)
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SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...


US Patent US10662186 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM444580
PNG
(US10662186, Compound 102)
Show SMILES CN(C)CCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CCCCC5)c4c3)ccc2C1
Show InChI InChI=1S/C30H36F2N8/c1-19-34-29-23(31)15-21(16-26(29)40(19)22-7-5-4-6-8-22)28-24(32)17-33-30(37-28)36-27-10-9-20-18-39(14-13-38(2)3)12-11-25(20)35-27/h9-10,15-17,22H,4-8,11-14,18H2,1-3H3,(H,33,35,36,37)
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SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...


US Patent US10662186 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM444594
PNG
(US10662186, Compound 130)
Show SMILES Cc1nc2c(F)cc(cc2n1C(C)(C)C)-c1nc(Nc2ccc3CN(C[C@H]4CNCCO4)CCc3n2)ncc1F
Show InChI InChI=1S/C29H34F2N8O/c1-17-34-27-21(30)11-19(12-24(27)39(17)29(2,3)4)26-22(31)14-33-28(37-26)36-25-6-5-18-15-38(9-7-23(18)35-25)16-20-13-32-8-10-40-20/h5-6,11-12,14,20,32H,7-10,13,15-16H2,1-4H3,(H,33,35,36,37)/t20-/m1/s1
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SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...


US Patent US10662186 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM444581
PNG
(US10662186, Compound 103 | US10662186, Compound 10...)
Show SMILES C[C@@H]1N(CCN(C)C)CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc12
Show InChI InChI=1S/C29H36F2N8/c1-17-20-8-9-25(34-23(20)10-11-38(17)13-12-37(6)7)35-28-32-16-22(31)26(36-28)19-14-21(30)27-24(15-19)39(18(2)33-27)29(3,4)5/h8-9,14-17H,10-13H2,1-7H3,(H,32,34,35,36)/t17-/m0/s1
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SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...


US Patent US10662186 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM444578
PNG
(US10662186, Compound 98)
Show SMILES CN(C)CCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CCCC5)c4c3)ccc2C1
Show InChI InChI=1S/C29H34F2N8/c1-18-33-28-22(30)14-20(15-25(28)39(18)21-6-4-5-7-21)27-23(31)16-32-29(36-27)35-26-9-8-19-17-38(13-12-37(2)3)11-10-24(19)34-26/h8-9,14-16,21H,4-7,10-13,17H2,1-3H3,(H,32,34,35,36)
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n/an/a 1.04n/an/an/an/an/an/a



SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...


US Patent US10662186 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM444546
PNG
(US10662186, Compound 66)
Show SMILES CN[C@H](C)C(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1
Show InChI InChI=1S/C27H28F2N8O/c1-14(30-3)26(38)36-9-8-21-16(13-36)4-7-23(33-21)34-27-31-12-20(29)24(35-27)17-10-19(28)25-22(11-17)37(15(2)32-25)18-5-6-18/h4,7,10-12,14,18,30H,5-6,8-9,13H2,1-3H3,(H,31,33,34,35)/t14-/m1/s1
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n/an/a 1.06n/an/an/an/an/an/a



SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...


US Patent US10662186 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM444564
PNG
(US10662186, Compound 83)
Show SMILES CCC(CC)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCN(C)C)CCc3n2)ncc1F
Show InChI InChI=1S/C29H36F2N8/c1-6-21(7-2)39-18(3)33-28-22(30)14-20(15-25(28)39)27-23(31)16-32-29(36-27)35-26-9-8-19-17-38(13-12-37(4)5)11-10-24(19)34-26/h8-9,14-16,21H,6-7,10-13,17H2,1-5H3,(H,32,34,35,36)
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n/an/a 1.08n/an/an/an/an/an/a



SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...


US Patent US10662186 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM444548
PNG
(US10662186, Compound 68)
Show SMILES Cc1nc2c(F)cc(cc2n1C(C)(C)C)-c1nc(Nc2ccc3CNCCc3n2)ncc1F
Show InChI InChI=1S/C24H25F2N7/c1-13-29-22-16(25)9-15(10-19(22)33(13)24(2,3)4)21-17(26)12-28-23(32-21)31-20-6-5-14-11-27-8-7-18(14)30-20/h5-6,9-10,12,27H,7-8,11H2,1-4H3,(H,28,30,31,32)
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n/an/a 1.09n/an/an/an/an/an/a



SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...


US Patent US10662186 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM444586
PNG
(US10662186, Compound 109 | US10662186, Compound 11...)
Show SMILES C[C@@H]1Cc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc2CN1
Show InChI InChI=1S/C25H27F2N7/c1-13-8-19-15(11-28-13)6-7-21(31-19)32-24-29-12-18(27)22(33-24)16-9-17(26)23-20(10-16)34(14(2)30-23)25(3,4)5/h6-7,9-10,12-13,28H,8,11H2,1-5H3,(H,29,31,32,33)/t13-/m1/s1
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n/an/a 1.09n/an/an/an/an/an/a



SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...


US Patent US10662186 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (Human))
BDBM444620
PNG
(US10662186, Compound 202)
Show SMILES Cc1nc2c(F)cc(cc2n1C(C)(C)C)-c1nc(Nc2ccc3CN(CCN)CCc3n2)ncc1F
Show InChI InChI=1S/C26H30F2N8/c1-15-31-24-18(27)11-17(12-21(24)36(15)26(2,3)4)23-19(28)13-30-25(34-23)33-22-6-5-16-14-35(10-8-29)9-7-20(16)32-22/h5-6,11-13H,7-10,14,29H2,1-4H3,(H,30,32,33,34)
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n/an/a 1.11n/an/an/an/an/an/a



SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...


US Patent US10662186 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM444552
PNG
(US10662186, Compound 72)
Show SMILES CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C2CCN(C2)C#C)ncc1F
Show InChI InChI=1S/C29H30F2N8/c1-5-37-10-8-21(16-37)38-11-9-24-19(15-38)6-7-26(34-24)35-29-32-14-23(31)27(36-29)20-12-22(30)28-25(13-20)39(17(2)3)18(4)33-28/h1,6-7,12-14,17,21H,8-11,15-16H2,2-4H3,(H,32,34,35,36)
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n/an/a 1.12n/an/an/an/an/an/a



SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...


US Patent US10662186 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM444541
PNG
(US10662186, Compound 61)
Show SMILES CN(C)CCN(C)C(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1
Show InChI InChI=1S/C29H33F2N9O/c1-17-33-27-21(30)13-19(14-24(27)40(17)20-6-7-20)26-22(31)15-32-28(36-26)35-25-8-5-18-16-39(10-9-23(18)34-25)29(41)38(4)12-11-37(2)3/h5,8,13-15,20H,6-7,9-12,16H2,1-4H3,(H,32,34,35,36)
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n/an/a 1.12n/an/an/an/an/an/a



SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...


US Patent US10662186 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM444543
PNG
(US10662186, Compound 63)
Show SMILES CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCN(C)C)CCc3n2)ncc1F
Show InChI InChI=1S/C27H32F2N8/c1-16(2)37-17(3)31-26-20(28)12-19(13-23(26)37)25-21(29)14-30-27(34-25)33-24-7-6-18-15-36(11-10-35(4)5)9-8-22(18)32-24/h6-7,12-14,16H,8-11,15H2,1-5H3,(H,30,32,33,34)
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n/an/a 1.12n/an/an/an/an/an/a



SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...


US Patent US10662186 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (Human))
BDBM444593
PNG
(US10662186, Compound 129)
Show SMILES Cc1nc2c(F)cc(cc2n1C(C)(C)C)-c1nc(Nc2ccc3CN(C[C@@H]4CNCCO4)CCc3n2)ncc1F
Show InChI InChI=1S/C29H34F2N8O/c1-17-34-27-21(30)11-19(12-24(27)39(17)29(2,3)4)26-22(31)14-33-28(37-26)36-25-6-5-18-15-38(9-7-23(18)35-25)16-20-13-32-8-10-40-20/h5-6,11-12,14,20,32H,7-10,13,15-16H2,1-4H3,(H,33,35,36,37)/t20-/m0/s1
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n/an/a 1.13n/an/an/an/an/an/a



SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...


US Patent US10662186 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM444549
PNG
(US10662186, Compound 69)
Show SMILES CN(C)CCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc2C1
Show InChI InChI=1S/C28H34F2N8/c1-17-32-26-20(29)13-19(14-23(26)38(17)28(2,3)4)25-21(30)15-31-27(35-25)34-24-8-7-18-16-37(12-11-36(5)6)10-9-22(18)33-24/h7-8,13-15H,9-12,16H2,1-6H3,(H,31,33,34,35)
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n/an/a 1.13n/an/an/an/an/an/a



SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...


US Patent US10662186 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM444620
PNG
(US10662186, Compound 202)
Show SMILES Cc1nc2c(F)cc(cc2n1C(C)(C)C)-c1nc(Nc2ccc3CN(CCN)CCc3n2)ncc1F
Show InChI InChI=1S/C26H30F2N8/c1-15-31-24-18(27)11-17(12-21(24)36(15)26(2,3)4)23-19(28)13-30-25(34-23)33-22-6-5-16-14-35(10-8-29)9-7-20(16)32-22/h5-6,11-13H,7-10,14,29H2,1-4H3,(H,30,32,33,34)
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n/an/a 1.14n/an/an/an/an/an/a



SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...


US Patent US10662186 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM444575
PNG
(US10662186, Compound 94)
Show SMILES CN1CCO[C@H](CN2CCc3nc(Nc4ncc(F)c(n4)-c4cc(F)c5nc(C)n(c5c4)C(C)(C)C)ccc3C2)C1
Show InChI InChI=1S/C30H36F2N8O/c1-18-34-28-22(31)12-20(13-25(28)40(18)30(2,3)4)27-23(32)14-33-29(37-27)36-26-7-6-19-15-39(9-8-24(19)35-26)17-21-16-38(5)10-11-41-21/h6-7,12-14,21H,8-11,15-17H2,1-5H3,(H,33,35,36,37)/t21-/m0/s1
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n/an/a 1.16n/an/an/an/an/an/a



SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...


US Patent US10662186 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM444571
PNG
(US10662186, Compound 90)
Show SMILES CN(C)CCCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc2C1
Show InChI InChI=1S/C29H36F2N8/c1-18-33-27-21(30)14-20(15-24(27)39(18)29(2,3)4)26-22(31)16-32-28(36-26)35-25-9-8-19-17-38(12-7-11-37(5)6)13-10-23(19)34-25/h8-9,14-16H,7,10-13,17H2,1-6H3,(H,32,34,35,36)
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n/an/a 1.16n/an/an/an/an/an/a



SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...


US Patent US10662186 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM444576
PNG
(US10662186, Compound 95)
Show SMILES CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(C\C=N\O)CCc3n2)ncc1F
Show InChI InChI=1S/C25H26F2N8O/c1-14(2)35-15(3)30-24-18(26)10-17(11-21(24)35)23-19(27)12-28-25(33-23)32-22-5-4-16-13-34(9-7-29-36)8-6-20(16)31-22/h4-5,7,10-12,14,36H,6,8-9,13H2,1-3H3,(H,28,31,32,33)/b29-7+
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n/an/a 1.18n/an/an/an/an/an/a



SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...


US Patent US10662186 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM444610
PNG
(US10662186, Compound 158)
Show SMILES CN(C)CCN(C)CCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc2C1
Show InChI InChI=1S/C31H41F2N9/c1-20-35-29-23(32)16-22(17-26(29)42(20)31(2,3)4)28-24(33)18-34-30(38-28)37-27-9-8-21-19-41(11-10-25(21)36-27)15-14-40(7)13-12-39(5)6/h8-9,16-18H,10-15,19H2,1-7H3,(H,34,36,37,38)
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n/an/a 1.27n/an/an/an/an/an/a



SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...


US Patent US10662186 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (Human))
BDBM444621
PNG
(US10662186, Compound 203)
Show SMILES CNCCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C3(C)CC3)ccc2C1
Show InChI InChI=1S/C27H30F2N8/c1-16-32-25-19(28)12-18(13-22(25)37(16)27(2)7-8-27)24-20(29)14-31-26(35-24)34-23-5-4-17-15-36(11-9-30-3)10-6-21(17)33-23/h4-5,12-14,30H,6-11,15H2,1-3H3,(H,31,33,34,35)
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n/an/a 1.28n/an/an/an/an/an/a



SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...


US Patent US10662186 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (Human))
BDBM444574
PNG
(US10662186, Compound 93)
Show SMILES CN1CCO[C@@H](CN2CCc3nc(Nc4ncc(F)c(n4)-c4cc(F)c5nc(C)n(c5c4)C(C)(C)C)ccc3C2)C1
Show InChI InChI=1S/C30H36F2N8O/c1-18-34-28-22(31)12-20(13-25(28)40(18)30(2,3)4)27-23(32)14-33-29(37-27)36-26-7-6-19-15-39(9-8-24(19)35-26)17-21-16-38(5)10-11-41-21/h6-7,12-14,21H,8-11,15-17H2,1-5H3,(H,33,35,36,37)/t21-/m1/s1
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n/an/a 1.33n/an/an/an/an/an/a



SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...


US Patent US10662186 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM444581
PNG
(US10662186, Compound 103 | US10662186, Compound 10...)
Show SMILES C[C@@H]1N(CCN(C)C)CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc12
Show InChI InChI=1S/C29H36F2N8/c1-17-20-8-9-25(34-23(20)10-11-38(17)13-12-37(6)7)35-28-32-16-22(31)26(36-28)19-14-21(30)27-24(15-19)39(18(2)33-27)29(3,4)5/h8-9,14-17H,10-13H2,1-7H3,(H,32,34,35,36)/t17-/m0/s1
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n/an/a 1.33n/an/an/an/an/an/a



SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...


US Patent US10662186 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM444551
PNG
(US10662186, Compound 71)
Show SMILES CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCN(C)CC#C)CCc3n2)ncc1F
Show InChI InChI=1S/C29H32F2N8/c1-6-10-37(5)12-13-38-11-9-24-20(17-38)7-8-26(34-24)35-29-32-16-23(31)27(36-29)21-14-22(30)28-25(15-21)39(18(2)3)19(4)33-28/h1,7-8,14-16,18H,9-13,17H2,2-5H3,(H,32,34,35,36)
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n/an/a 1.34n/an/an/an/an/an/a



SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...


US Patent US10662186 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM444545
PNG
(US10662186, Compound 65 | US10662186, Compound 67)
Show SMILES Cc1nc2c(F)cc(cc2n1C1CC1)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)C2CCCN2)ncc1F
Show InChI InChI=1S/C28H28F2N8O/c1-15-33-26-19(29)11-17(12-23(26)38(15)18-5-6-18)25-20(30)13-32-28(36-25)35-24-7-4-16-14-37(10-8-21(16)34-24)27(39)22-3-2-9-31-22/h4,7,11-13,18,22,31H,2-3,5-6,8-10,14H2,1H3,(H,32,34,35,36)
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n/an/a 1.35n/an/an/an/an/an/a



SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...


US Patent US10662186 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM444598
PNG
(US10662186, Compound 134)
Show SMILES CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCN(C)CC[Si](C)(C)C)CCc3n2)ncc1F
Show InChI InChI=1S/C31H42F2N8Si/c1-20(2)41-21(3)35-30-24(32)16-23(17-27(30)41)29-25(33)18-34-31(38-29)37-28-9-8-22-19-40(11-10-26(22)36-28)13-12-39(4)14-15-42(5,6)7/h8-9,16-18,20H,10-15,19H2,1-7H3,(H,34,36,37,38)
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n/an/a 1.35n/an/an/an/an/an/a



SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...


US Patent US10662186 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (Human))
BDBM444629
PNG
(US10662186, Compound 211)
Show SMILES Cc1nc2c(F)cc(cc2n1C(C)(C)C)-c1nc(Nc2ccc3CN(CCN4CCC(CC4)B(O)O)CCc3n2)ncc1F
Show InChI InChI=1S/C31H39BF2N8O2/c1-19-36-29-23(33)15-21(16-26(29)42(19)31(2,3)4)28-24(34)17-35-30(39-28)38-27-6-5-20-18-41(12-9-25(20)37-27)14-13-40-10-7-22(8-11-40)32(43)44/h5-6,15-17,22,43-44H,7-14,18H2,1-4H3,(H,35,37,38,39)
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n/an/a 1.36n/an/an/an/an/an/a



SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...


US Patent US10662186 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (Human))
BDBM444575
PNG
(US10662186, Compound 94)
Show SMILES CN1CCO[C@H](CN2CCc3nc(Nc4ncc(F)c(n4)-c4cc(F)c5nc(C)n(c5c4)C(C)(C)C)ccc3C2)C1
Show InChI InChI=1S/C30H36F2N8O/c1-18-34-28-22(31)12-20(13-25(28)40(18)30(2,3)4)27-23(32)14-33-29(37-27)36-26-7-6-19-15-39(9-8-24(19)35-26)17-21-16-38(5)10-11-41-21/h6-7,12-14,21H,8-11,15-17H2,1-5H3,(H,33,35,36,37)/t21-/m0/s1
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n/an/a 1.37n/an/an/an/an/an/a



SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...


US Patent US10662186 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM444589
PNG
(US10662186, Compound 112 | US10662186, Compound 11...)
Show SMILES C[C@@H]1Cc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc2CN1CCN(C)C
Show InChI InChI=1S/C29H36F2N8/c1-17-12-23-19(16-38(17)11-10-37(6)7)8-9-25(34-23)35-28-32-15-22(31)26(36-28)20-13-21(30)27-24(14-20)39(18(2)33-27)29(3,4)5/h8-9,13-15,17H,10-12,16H2,1-7H3,(H,32,34,35,36)/t17-/m1/s1
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n/an/a 1.37n/an/an/an/an/an/a



SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...


US Patent US10662186 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM444626
PNG
(US10662186, Compound 208)
Show SMILES Cc1nc2c(F)cc(cc2n1C(C)(C)C)-c1nc(Nc2ccc3CN(CCS(C)(=O)=O)CCc3n2)ncc1F
Show InChI InChI=1S/C27H31F2N7O2S/c1-16-31-25-19(28)12-18(13-22(25)36(16)27(2,3)4)24-20(29)14-30-26(34-24)33-23-7-6-17-15-35(9-8-21(17)32-23)10-11-39(5,37)38/h6-7,12-14H,8-11,15H2,1-5H3,(H,30,32,33,34)
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n/an/a 1.39n/an/an/an/an/an/a



SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...


US Patent US10662186 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (Human))
BDBM444573
PNG
(US10662186, Compound 92)
Show SMILES CN(C)CCC(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc2C1
Show InChI InChI=1S/C29H34F2N8O/c1-17-33-27-20(30)13-19(14-23(27)39(17)29(2,3)4)26-21(31)15-32-28(36-26)35-24-8-7-18-16-38(12-9-22(18)34-24)25(40)10-11-37(5)6/h7-8,13-15H,9-12,16H2,1-6H3,(H,32,34,35,36)
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n/an/a 1.39n/an/an/an/an/an/a



SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...


US Patent US10662186 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (Human))
BDBM444569
PNG
(US10662186, Compound 88)
Show SMILES CN(C)CCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C3(C)CC3)ccc2C1
Show InChI InChI=1S/C28H32F2N8/c1-17-32-26-20(29)13-19(14-23(26)38(17)28(2)8-9-28)25-21(30)15-31-27(35-25)34-24-6-5-18-16-37(12-11-36(3)4)10-7-22(18)33-24/h5-6,13-15H,7-12,16H2,1-4H3,(H,31,33,34,35)
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n/an/a 1.41n/an/an/an/an/an/a



SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...


US Patent US10662186 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (Human))
BDBM444595
PNG
(US10662186, Compound 131)
Show SMILES CN1CCC[C@H]1CN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1
Show InChI InChI=1S/C29H32F2N8/c1-17-33-28-22(30)12-19(13-25(28)39(17)20-6-7-20)27-23(31)14-32-29(36-27)35-26-8-5-18-15-38(11-9-24(18)34-26)16-21-4-3-10-37(21)2/h5,8,12-14,20-21H,3-4,6-7,9-11,15-16H2,1-2H3,(H,32,34,35,36)/t21-/m0/s1
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n/an/a 1.41n/an/an/an/an/an/a



SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...


US Patent US10662186 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM444542
PNG
(US10662186, Compound 62)
Show SMILES CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)[C@@H](C)N(C)C)ncc1F
Show InChI InChI=1S/C28H32F2N8O/c1-15(2)38-17(4)32-26-20(29)11-19(12-23(26)38)25-21(30)13-31-28(35-25)34-24-8-7-18-14-37(10-9-22(18)33-24)27(39)16(3)36(5)6/h7-8,11-13,15-16H,9-10,14H2,1-6H3,(H,31,33,34,35)/t16-/m1/s1
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n/an/a 1.44n/an/an/an/an/an/a



SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...


US Patent US10662186 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM444608
PNG
(US10662186, Compound 155)
Show SMILES Cc1nc2c(F)cc(cc2n1C(C)(C)C)-c1nc(Nc2ccc3CN(CCN4CCP(C)(=O)CC4)CCc3n2)ncc1F
Show InChI InChI=1S/C31H39F2N8OP/c1-20-35-29-23(32)16-22(17-26(29)41(20)31(2,3)4)28-24(33)18-34-30(38-28)37-27-7-6-21-19-40(9-8-25(21)36-27)11-10-39-12-14-43(5,42)15-13-39/h6-7,16-18H,8-15,19H2,1-5H3,(H,34,36,37,38)
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n/an/a 1.45n/an/an/an/an/an/a



SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...


US Patent US10662186 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM444629
PNG
(US10662186, Compound 211)
Show SMILES Cc1nc2c(F)cc(cc2n1C(C)(C)C)-c1nc(Nc2ccc3CN(CCN4CCC(CC4)B(O)O)CCc3n2)ncc1F
Show InChI InChI=1S/C31H39BF2N8O2/c1-19-36-29-23(33)15-21(16-26(29)42(19)31(2,3)4)28-24(34)17-35-30(39-28)38-27-6-5-20-18-41(12-9-25(20)37-27)14-13-40-10-7-22(8-11-40)32(43)44/h5-6,15-17,22,43-44H,7-14,18H2,1-4H3,(H,35,37,38,39)
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n/an/a 1.45n/an/an/an/an/an/a



SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...


US Patent US10662186 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM444540
PNG
(US10662186, Compound 60)
Show SMILES CN(C)CC(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(CC5CC5)c4c3)ccc2C1
Show InChI InChI=1S/C28H30F2N8O/c1-16-32-27-20(29)10-19(11-23(27)38(16)13-17-4-5-17)26-21(30)12-31-28(35-26)34-24-7-6-18-14-37(9-8-22(18)33-24)25(39)15-36(2)3/h6-7,10-12,17H,4-5,8-9,13-15H2,1-3H3,(H,31,33,34,35)
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n/an/a 1.47n/an/an/an/an/an/a



SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...


US Patent US10662186 (2020)

More data for this
Ligand-Target Pair
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