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Patent code US10662189

Compile Data Set for Download or QSAR
Found 84 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444781
PNG
(US10662189, Compound WX032)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2ncc(cc2[nH]c1=O)-c1ccccc1C#N
PDB

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US Patent
n/an/a 0.234n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444767
PNG
(US10662189, Compound WX018)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2ncc(cc2[nH]c1=O)-c1ccccc1C(F)(F)F
PDB

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n/an/a 0.391n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444825
PNG
(US10662189, Compound WX076)
Show SMILES CCOc1cc(ccc1OC(F)F)C(CS(C)(=O)=O)n1c2ncc(c(C)c2[nH]c1=O)-c1ccccc1C
PDB

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n/an/a<0.5n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444765
PNG
(US10662189, Compound WX016)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2ncc(cc2[nH]c1=O)-c1ccccc1Cl
PDB

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n/an/a<0.5n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444763
PNG
(US10662189, Compound WX014)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2ncc(cc2[nH]c1=O)-c1ccccc1C
PDB

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n/an/a<0.5n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444822
PNG
(US10662189, Compound WX073)
Show SMILES CCOc1cc(ccc1OC(F)F)C(CS(C)(=O)=O)n1c2ncc(cc2nc1=O)-c1ccccc1F
PDB

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n/an/a<0.5n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444827
PNG
(US10662189, Compound WX078)
Show SMILES CCOc1cc(ccc1OC(F)F)C(CS(C)(=O)=O)n1c2nccc(-c3ccccc3)c2[nH]c1=O
PDB

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n/an/a<0.5n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444779
PNG
(US10662189, Compound WX030)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2ncc(cc2[nH]c1=O)-c1ccccc1CC
PDB

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n/an/a 0.515n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444812
PNG
(US10662189, Compound WX063)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2ncc(c(C)c2nc1=O)-c1ccccc1F
PDB

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n/an/a 0.560n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444766
PNG
(US10662189, Compound WX017)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2ncc(cc2[nH]c1=O)-c1ccccc1OC
PDB

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n/an/a 0.641n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444782
PNG
(US10662189, Compound WX033)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2ncc(cc2[nH]c1=O)-c1c(F)cccc1F
PDB

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n/an/a 0.671n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444812
PNG
(US10662189, Compound WX063)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2ncc(c(C)c2nc1=O)-c1ccccc1F
PDB

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n/an/a 0.685n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444820
PNG
(US10662189, Compound WX071)
Show SMILES CCOc1cc(ccc1OC)C(CS(C)(=O)=O)n1c2ncc(cc2oc1=O)-c1ccccc1C
Show InChI InChI=1S/C25H26N2O6S/c1-5-32-22-12-17(10-11-21(22)31-3)20(15-34(4,29)30)27-24-23(33-25(27)28)13-18(14-26-24)19-9-7-6-8-16(19)2/h6-14,20H,5,15H2,1-4H3
PDB

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n/an/a 0.740n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444755
PNG
(US10662189, Compound WX006 | US10662189, Compound ...)
Show SMILES CCOc1cc(CC(CS(C)(=O)=O)n2c3ncc(Cc4ccccc4F)cc3[nH]c2=O)ccc1OC
PDB

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n/an/a 0.860n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444780
PNG
(US10662189, Compound WX031)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2ncc(cc2[nH]c1=O)-c1ccccc1OCC
PDB

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n/an/a 0.861n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444810
PNG
(US10662189, Compound WX061)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2ncc(cc2n(CC#N)c1=O)-c1ccccc1F
Show InChI InChI=1S/C26H25FN4O5S/c1-4-36-24-14-17(9-10-23(24)35-2)22(16-37(3,33)34)31-25-21(30(12-11-28)26(31)32)13-18(15-29-25)19-7-5-6-8-20(19)27/h5-10,13-15,22H,4,12,16H2,1-3H3/t22-/m1/s1
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n/an/a 0.989n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444762
PNG
(US10662189, Compound WX013)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2ncc(cc2[nH]c1=O)-c1cccc(F)c1F
PDB

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n/an/a 0.994n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444826
PNG
(US10662189, Compound WX077)
Show SMILES CCOc1cc(ccc1OC(F)F)C(CS(C)(=O)=O)n1c2ncc(-c3ccccc3)c(C)c2[nH]c1=O
PDB

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n/an/a 1.01n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444823
PNG
(US10662189, Compound WX074)
Show SMILES CCOc1cc(ccc1OC(F)F)C(CS(C)(=O)=O)n1c2ncc(cc2oc1=O)-c1ccccc1
Show InChI InChI=1S/C24H22F2N2O6S/c1-3-32-20-11-16(9-10-19(20)33-23(25)26)18(14-35(2,30)31)28-22-21(34-24(28)29)12-17(13-27-22)15-7-5-4-6-8-15/h4-13,18,23H,3,14H2,1-2H3
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n/an/a 1.03n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444764
PNG
(US10662189, Compound WX015)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2ncc(cc2[nH]c1=O)-c1ccccc1C(C)C
PDB

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n/an/a 1.04n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444806
PNG
(US10662189, Compound WX057)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2ncc(cc2n(C)c1=O)-c1ccccc1F
Show InChI InChI=1S/C25H26FN3O5S/c1-5-34-23-13-16(10-11-22(23)33-3)21(15-35(4,31)32)29-24-20(28(2)25(29)30)12-17(14-27-24)18-8-6-7-9-19(18)26/h6-14,21H,5,15H2,1-4H3/t21-/m1/s1
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n/an/a 1.25n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444802
PNG
(US10662189, Compound WX053)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2ncc(Br)cc2n(Cc2ccccc2F)c1=O
Show InChI InChI=1S/C25H25BrFN3O5S/c1-4-35-23-11-16(9-10-22(23)34-2)21(15-36(3,32)33)30-24-20(12-18(26)13-28-24)29(25(30)31)14-17-7-5-6-8-19(17)27/h5-13,21H,4,14-15H2,1-3H3/t21-/m1/s1
PDB

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n/an/a 1.49n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444755
PNG
(US10662189, Compound WX006 | US10662189, Compound ...)
Show SMILES CCOc1cc(CC(CS(C)(=O)=O)n2c3ncc(Cc4ccccc4F)cc3[nH]c2=O)ccc1OC
PDB

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n/an/a 1.80n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444814
PNG
(US10662189, Compound WX065)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2nccc(-c3ccccc3F)c2nc1=O
PDB

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n/an/a 1.87n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444807
PNG
(US10662189, Compound WX058)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2ncc(cc2n(CC)c1=O)-c1ccccc1F
Show InChI InChI=1S/C26H28FN3O5S/c1-5-29-21-13-18(19-9-7-8-10-20(19)27)15-28-25(21)30(26(29)31)22(16-36(4,32)33)17-11-12-23(34-3)24(14-17)35-6-2/h7-15,22H,5-6,16H2,1-4H3/t22-/m1/s1
PDB

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n/an/a 1.99n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444808
PNG
(US10662189, Compound WX059)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2ncc(cc2n(CCO)c1=O)-c1ccccc1F
Show InChI InChI=1S/C26H28FN3O6S/c1-4-36-24-14-17(9-10-23(24)35-2)22(16-37(3,33)34)30-25-21(29(11-12-31)26(30)32)13-18(15-28-25)19-7-5-6-8-20(19)27/h5-10,13-15,22,31H,4,11-12,16H2,1-3H3/t22-/m1/s1
PDB

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n/an/a 2.02n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444813
PNG
(US10662189, Compound WX064)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2ncc(-c3ccccc3)c(C)c2nc1=O
PDB

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n/an/a 2.23n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444817
PNG
(US10662189, Compound WX068)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2nccc(Cc3ccccc3C)c2nc1=O
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n/an/a 2.24n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444815
PNG
(US10662189, Compound WX066)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2nccc(-c3ccccc3)c2nc1=O
PDB

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n/an/a 2.48n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444792
PNG
(US10662189, Compound WX043)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2ncc(Oc3ccccc3C(F)(F)F)cc2[nH]c1=O
PDB

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n/an/a 2.53n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444759
PNG
(US10662189, Compound WX010)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2ncc(cc2[nH]c1=O)-c1ccccc1
PDB

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n/an/a 2.60n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444773
PNG
(US10662189, Compound WX024)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2ncc(Cc3ccccc3F)cc2n(-c2ccccc2F)c1=O
Show InChI InChI=1S/C31H29F2N3O5S/c1-4-41-29-17-22(13-14-28(29)40-2)27(19-42(3,38)39)36-30-26(35(31(36)37)25-12-8-7-11-24(25)33)16-20(18-34-30)15-21-9-5-6-10-23(21)32/h5-14,16-18,27H,4,15,19H2,1-3H3/t27-/m1/s1
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n/an/a 2.70n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444756
PNG
(US10662189, Compound WX007)
Show SMILES CCOc1cc(CC(CS(C)(=O)=O)n2c3ncc(CC=C(C)C)cc3[nH]c2=O)ccc1OC
PDB

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n/an/a 2.81n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444768
PNG
(US10662189, Compound WX019)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2ncc(cc2[nH]c1=O)-c1cn[nH]c1
PDB

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n/an/a 3.38n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444760
PNG
(US10662189, Compound WX011)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2ncc(cc2[nH]c1=O)-c1cccc(F)c1
PDB

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n/an/a 3.40n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444805
PNG
(US10662189, Compound WX056)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2ncc(Br)cc2nc1=O
PDB

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n/an/a 3.40n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444806
PNG
(US10662189, Compound WX057)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2ncc(cc2n(C)c1=O)-c1ccccc1F
Show InChI InChI=1S/C25H26FN3O5S/c1-5-34-23-13-16(10-11-22(23)33-3)21(15-35(4,31)32)29-24-20(28(2)25(29)30)12-17(14-27-24)18-8-6-7-9-19(18)26/h6-14,21H,5,15H2,1-4H3/t21-/m1/s1
PDB

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n/an/a 3.40n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444809
PNG
(US10662189, Compound WX060)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2ncc(cc2n(C(C)C)c1=O)-c1ccccc1F
Show InChI InChI=1S/C27H30FN3O5S/c1-6-36-25-14-18(11-12-24(25)35-4)23(16-37(5,33)34)31-26-22(30(17(2)3)27(31)32)13-19(15-29-26)20-9-7-8-10-21(20)28/h7-15,17,23H,6,16H2,1-5H3/t23-/m1/s1
PDB

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n/an/a 3.48n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444811
PNG
(US10662189, Compound WX062)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2ncc(cc2n(C2CCC2)c1=O)-c1ccccc1F
Show InChI InChI=1S/C28H30FN3O5S/c1-4-37-26-15-18(12-13-25(26)36-2)24(17-38(3,34)35)32-27-23(31(28(32)33)20-8-7-9-20)14-19(16-30-27)21-10-5-6-11-22(21)29/h5-6,10-16,20,24H,4,7-9,17H2,1-3H3/t24-/m1/s1
PDB

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n/an/a 3.5n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444815
PNG
(US10662189, Compound WX066)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2nccc(-c3ccccc3)c2nc1=O
PDB

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n/an/a 3.80n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444761
PNG
(US10662189, Compound WX012)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2ncc(cc2[nH]c1=O)-c1ccc(F)cc1
PDB

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n/an/a 3.90n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444775
PNG
(US10662189, Compound WX026)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2ncc(cc2[nH]c1=O)-c1ncccn1
PDB

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n/an/a 4.51n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444757
PNG
(US10662189, Compound WX008)
Show SMILES CCOc1cc(CC(CS(C)(=O)=O)n2c3ncc(CC(C)C)cc3[nH]c2=O)ccc1OC
PDB

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n/an/a 4.89n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444735
PNG
(US10662189, Compound WX005)
Show SMILES CCOc1cc(CC(CS(C)(=O)=O)n2c3ncc(cc3[nH]c2=O)C2CC2)ccc1OC
PDB

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n/an/a 5.03n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444783
PNG
(US10662189, Compound WX034)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2ncc(cc2[nH]c1=O)-c1c(C)ncnc1C
PDB

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n/an/a 5.18n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444824
PNG
(US10662189, Compound WX075)
Show SMILES CCOc1cc(ccc1OC(F)F)C(CS(C)(=O)=O)n1c2ncc(C)c(C)c2[nH]c1=O
PDB

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n/an/a 5.39n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444791
PNG
(US10662189, Compound WX042)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2ncc(Oc3ncccn3)cc2nc1=O
PDB

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n/an/a 5.42n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444675
PNG
(US10662189, Compound WX002)
Show SMILES CCOc1cc(CC(CS(C)(=O)=O)n2c3ncc(cc3[nH]c2=O)C(F)(F)F)ccc1OC
PDB

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n/an/a 5.66n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444785
PNG
(US10662189, Compound WX036)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2ncc(cc2[nH]c1=O)-c1cscn1
PDB

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n/an/a 6.27n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444816
PNG
(US10662189, Compound WX067)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2nccc(-c3cnn(C)c3)c2nc1=O
PDB

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n/an/a 6.40n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444794
PNG
(US10662189, Compound WX045)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2ncc(Br)cc2n(C2CC2)c1=O
Show InChI InChI=1S/C21H24BrN3O5S/c1-4-30-19-9-13(5-8-18(19)29-2)17(12-31(3,27)28)25-20-16(10-14(22)11-23-20)24(21(25)26)15-6-7-15/h5,8-11,15,17H,4,6-7,12H2,1-3H3/t17-/m1/s1
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n/an/a 6.5n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444803
PNG
(US10662189, Compound WX054)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2ncc(Br)cc2n(Cc2nccc(C)n2)c1=O
Show InChI InChI=1S/C24H26BrN5O5S/c1-5-35-21-10-16(6-7-20(21)34-3)19(14-36(4,32)33)30-23-18(11-17(25)12-27-23)29(24(30)31)13-22-26-9-8-15(2)28-22/h6-12,19H,5,13-14H2,1-4H3/t19-/m1/s1
PDB

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n/an/a 6.90n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444804
PNG
(US10662189, Compound WX055)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2ncc(Br)cc2n(Cc2cncc(C)n2)c1=O
Show InChI InChI=1S/C24H26BrN5O5S/c1-5-35-22-8-16(6-7-21(22)34-3)20(14-36(4,32)33)30-23-19(9-17(25)11-27-23)29(24(30)31)13-18-12-26-10-15(2)28-18/h6-12,20H,5,13-14H2,1-4H3/t20-/m1/s1
PDB

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n/an/a 6.99n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444719
PNG
(US10662189, Compound WX004)
Show SMILES CCOc1cc(CC(CS(C)(=O)=O)n2c3ncc(Br)cc3[nH]c2=O)ccc1OC
PDB

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n/an/a 7.09n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444795
PNG
(US10662189, Compound WX046)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2ncc(cc2n(C2CC2)c1=O)-c1ccccc1F
Show InChI InChI=1S/C27H28FN3O5S/c1-4-36-25-14-17(9-12-24(25)35-2)23(16-37(3,33)34)31-26-22(30(27(31)32)19-10-11-19)13-18(15-29-26)20-7-5-6-8-21(20)28/h5-9,12-15,19,23H,4,10-11,16H2,1-3H3/t23-/m1/s1
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n/an/a 7.79n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444801
PNG
(US10662189, Compound WX052)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2ncc(Br)cc2n(CCS(C)(=O)=O)c1=O
Show InChI InChI=1S/C21H26BrN3O7S2/c1-5-32-19-10-14(6-7-18(19)31-2)17(13-34(4,29)30)25-20-16(11-15(22)12-23-20)24(21(25)26)8-9-33(3,27)28/h6-7,10-12,17H,5,8-9,13H2,1-4H3/t17-/m1/s1
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n/an/a 8.20n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444814
PNG
(US10662189, Compound WX065)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2nccc(-c3ccccc3F)c2nc1=O
PDB

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n/an/a 8.80n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444800
PNG
(US10662189, Compound WX051)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2ncc(Br)cc2n(CCOC)c1=O
Show InChI InChI=1S/C21H26BrN3O6S/c1-5-31-19-10-14(6-7-18(19)30-3)17(13-32(4,27)28)25-20-16(11-15(22)12-23-20)24(21(25)26)8-9-29-2/h6-7,10-12,17H,5,8-9,13H2,1-4H3/t17-/m1/s1
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n/an/a 9.10n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444639
PNG
(US10662189, Compound WX001)
Show SMILES CCOc1cc(CC(CS(C)(=O)=O)n2c3ncc(Cl)cc3[nH]c2=O)ccc1OC
PDB

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n/an/a 9.48n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444774
PNG
(US10662189, Compound WX025)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2ncc(cc2[nH]c1=O)-c1cccnc1
PDB

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n/an/a 9.53n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444777
PNG
(US10662189, Compound WX028)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2ncc(cc2[nH]c1=O)-c1nccc(C)n1
PDB

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n/an/a 9.70n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444786
PNG
(US10662189, Compound WX037)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2ncc(cc2[nH]c1=O)-c1ncccc1F
PDB

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n/an/a 10.2n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444789
PNG
(US10662189, Compound WX040)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2ncc(cc2[nH]c1=O)C1=CCN(CC1)C(=O)OC(C)(C)C
PDB

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n/an/a 10.4n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444689
PNG
(US10662189, Compound WX003)
Show SMILES CCOc1cc(CC(CS(C)(=O)=O)n2c3ncc(F)cc3[nH]c2=O)ccc1OC
PDB

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n/an/a 10.6n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444799
PNG
(US10662189, Compound WX050)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2ncc(Br)cc2n(C)c1=O
Show InChI InChI=1S/C19H22BrN3O5S/c1-5-28-17-8-12(6-7-16(17)27-3)15(11-29(4,25)26)23-18-14(22(2)19(23)24)9-13(20)10-21-18/h6-10,15H,5,11H2,1-4H3/t15-/m1/s1
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n/an/a 11n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444787
PNG
(US10662189, Compound WX038)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2ncc(cc2[nH]c1=O)-c1nccnc1C
PDB

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n/an/a 14.5n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444778
PNG
(US10662189, Compound WX029)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2ncc(cc2[nH]c1=O)-c1cncnc1C
PDB

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n/an/a 14.8n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444784
PNG
(US10662189, Compound WX035)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2ncc(cc2[nH]c1=O)-c1ccncc1
PDB

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n/an/a 15.5n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444790
PNG
(US10662189, Compound WX041)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2ncc(OC)cc2n(C)c1=O
Show InChI InChI=1S/C20H25N3O6S/c1-6-29-18-9-13(7-8-17(18)28-4)16(12-30(5,25)26)23-19-15(22(2)20(23)24)10-14(27-3)11-21-19/h7-11,16H,6,12H2,1-5H3/t16-/m1/s1
PDB

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n/an/a 16.4n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50248919
PNG
((S)-N-(2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsu...)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)N1C(=O)c2cccc(NC(C)=O)c2C1=O
Show InChI InChI=1S/C22H24N2O7S/c1-5-31-19-11-14(9-10-18(19)30-3)17(12-32(4,28)29)24-21(26)15-7-6-8-16(23-13(2)25)20(15)22(24)27/h6-11,17H,5,12H2,1-4H3,(H,23,25)/t17-/m1/s1
PDB

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US Patent
n/an/a 16.5n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444816
PNG
(US10662189, Compound WX067)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2nccc(-c3cnn(C)c3)c2nc1=O
PDB

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n/an/a 18.5n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444776
PNG
(US10662189, Compound WX027)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2ncc(cc2[nH]c1=O)-c1cncnc1
PDB

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n/an/a 19.1n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444797
PNG
(US10662189, Compound WX048)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2ncc(Cl)cc2n(CC(F)(F)F)c1=O
Show InChI InChI=1S/C20H21ClF3N3O5S/c1-4-32-17-7-12(5-6-16(17)31-2)15(10-33(3,29)30)27-18-14(8-13(21)9-25-18)26(19(27)28)11-20(22,23)24/h5-9,15H,4,10-11H2,1-3H3/t15-/m1/s1
PDB

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n/an/a 19.8n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444788
PNG
(US10662189, Compound WX039)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2ncc(cc2[nH]c1=O)-c1nnccc1C
PDB

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SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444821
PNG
(US10662189, Compound WX072)
Show SMILES CCOc1cc(ccc1OC)C(CS(C)(=O)=O)n1c2nccc(-c3ccccc3F)c2oc1=O
Show InChI InChI=1S/C24H23FN2O6S/c1-4-32-21-13-15(9-10-20(21)31-2)19(14-34(3,29)30)27-23-22(33-24(27)28)17(11-12-26-23)16-7-5-6-8-18(16)25/h5-13,19H,4,14H2,1-3H3
PDB

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n/an/a 24.6n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444770
PNG
(US10662189, Compound WX021)
Show SMILES CCOc1cc(ccc1OC)C(CS(C)(=O)=O)n1c2ncc(cc2[nH]c1=O)-n1ccccc1=O
PDB

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n/an/a 26.1n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444771
PNG
(US10662189, Compound WX022)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2ncc(cc2[nH]c1=O)C#N
PDB

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n/an/a 26.5n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444793
PNG
(US10662189, Compound WX044)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2ncc(Br)cc2n(-c2ccccc2)c1=O
Show InChI InChI=1S/C24H24BrN3O5S/c1-4-33-22-12-16(10-11-21(22)32-2)20(15-34(3,30)31)28-23-19(13-17(25)14-26-23)27(24(28)29)18-8-6-5-7-9-18/h5-14,20H,4,15H2,1-3H3/t20-/m1/s1
PDB

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SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444796
PNG
(US10662189, Compound WX047)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2ncc(C)cc2n(CC(F)F)c1=O
Show InChI InChI=1S/C21H25F2N3O5S/c1-5-31-18-9-14(6-7-17(18)30-3)16(12-32(4,28)29)26-20-15(8-13(2)10-24-20)25(21(26)27)11-19(22)23/h6-10,16,19H,5,11-12H2,1-4H3/t16-/m1/s1
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n/an/a 41.6n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444818
PNG
(US10662189, Compound WX069)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)N1C(=O)Cc2cc(Br)cnc12
Show InChI InChI=1S/C19H21BrN2O5S/c1-4-27-17-8-12(5-6-16(17)26-2)15(11-28(3,24)25)22-18(23)9-13-7-14(20)10-21-19(13)22/h5-8,10,15H,4,9,11H2,1-3H3/t15-/m1/s1
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n/an/a 47.8n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444769
PNG
(US10662189, Compound WX020)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2ncc(C)cc2[nH]c1=O
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n/an/a 65.8n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444772
PNG
(US10662189, Compound WX023)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2ncc(CO)cc2[nH]c1=O
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n/an/a 68.1n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444819
PNG
(US10662189, Compound WX070)
Show SMILES CCOc1cc(ccc1OC)C(CS(C)(=O)=O)n1c2ncc(Br)cc2oc1=O
Show InChI InChI=1S/C18H19BrN2O6S/c1-4-26-15-7-11(5-6-14(15)25-2)13(10-28(3,23)24)21-17-16(27-18(21)22)8-12(19)9-20-17/h5-9,13H,4,10H2,1-3H3
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n/an/a 73.8n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM444798
PNG
(US10662189, Compound WX049)
Show SMILES CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)n1c2ncc(F)cc2n(CC(F)F)c1=O
Show InChI InChI=1S/C20H22F3N3O5S/c1-4-31-17-7-12(5-6-16(17)30-2)15(11-32(3,28)29)26-19-14(8-13(21)9-24-19)25(20(26)27)10-18(22)23/h5-9,15,18H,4,10-11H2,1-3H3/t15-/m1/s1
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n/an/a 90.7n/an/an/an/an/an/a



SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.

US Patent


Assay Description
The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...


US Patent US10662189 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%