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Patent code US10668033

Compile Data Set for Download or QSAR
Found 4 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prostanoid IP receptor


(Homo sapiens (Human))
BDBM444830
PNG
(2-(((1r,4r)-4-((3-(3- chlorophenyl)-3- phenylureid...)
Show SMILES OC(=O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cccc(Cl)c2)CC1
Show InChI InChI=1S/C23H27ClN2O4/c24-19-5-4-8-21(13-19)26(20-6-2-1-3-7-20)23(29)25-14-17-9-11-18(12-10-17)15-30-16-22(27)28/h1-8,13,17-18H,9-12,14-16H2,(H,25,29)(H,27,28)/t17-,18-
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US Patent
n/an/an/an/a 61.1n/an/an/an/a



ARENA PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds were screened for agonists of the human prostacyclin (PGI2) receptor using the HTRF assay for direct cAMP measurement (Gabriel et al., ASSA...


US Patent US10668033 (2020)

More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (Human))
BDBM50235379
PNG
(CHEMBL3932106 | US10668033, Compound 55)
Show SMILES COc1ccc(cc1)N(C(=O)OC[C@H]1CC[C@H](COCC(O)=O)CC1)c1cccc(F)c1
Show InChI InChI=1S/C24H28FNO6/c1-30-22-11-9-20(10-12-22)26(21-4-2-3-19(25)13-21)24(29)32-15-18-7-5-17(6-8-18)14-31-16-23(27)28/h2-4,9-13,17-18H,5-8,14-16H2,1H3,(H,27,28)/t17-,18-
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Patents


Similars

US Patent
n/an/an/an/a 5.14n/an/an/an/a



ARENA PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds were screened for agonists of the human prostacyclin (PGI2) receptor using the HTRF assay for direct cAMP measurement (Gabriel et al., ASSA...


US Patent US10668033 (2020)

More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (Human))
BDBM444835
PNG
(2-(((1r,4r)-4-(((3- fluorophenyl)(5-methylthiophen...)
Show SMILES Cc1ccc(s1)N(C(=O)OC[C@H]1CC[C@H](COCC(O)=O)CC1)c1cccc(F)c1
Show InChI InChI=1S/C22H26FNO5S/c1-15-5-10-20(30-15)24(19-4-2-3-18(23)11-19)22(27)29-13-17-8-6-16(7-9-17)12-28-14-21(25)26/h2-5,10-11,16-17H,6-9,12-14H2,1H3,(H,25,26)/t16-,17-
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US Patent
n/an/an/an/a 19.1n/an/an/an/a



ARENA PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds were screened for agonists of the human prostacyclin (PGI2) receptor using the HTRF assay for direct cAMP measurement (Gabriel et al., ASSA...


US Patent US10668033 (2020)

More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (Human))
BDBM444831
PNG
(2-(((1s,4s)-4-(((4- fluorophenyl)(phenyl) carbamoy...)
Show SMILES OC(=O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccc(F)cc2)CC1
Show InChI InChI=1S/C23H26FNO5/c24-19-10-12-21(13-11-19)25(20-4-2-1-3-5-20)23(28)30-15-18-8-6-17(7-9-18)14-29-16-22(26)27/h1-5,10-13,17-18H,6-9,14-16H2,(H,26,27)/t17-,18+
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US Patent
n/an/an/an/a 56.9n/an/an/an/a



ARENA PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds were screened for agonists of the human prostacyclin (PGI2) receptor using the HTRF assay for direct cAMP measurement (Gabriel et al., ASSA...


US Patent US10668033 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%