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Patent code US10668067

Compile Data Set for Download or QSAR
Found 135 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444935
PNG
(6-((4'-fluoro-3-methoxy-3'-(trifluoromethoxy)-4- |...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ncccn1)c1ccc(cc1OC)-c1ccc(F)c(OC(F)(F)F)c1
Show InChI InChI=1S/C25H20F4N6O5S/c1-30-24(36)35(22-9-6-17(14-33-22)41(37,38)34-23-31-10-3-11-32-23)19-8-5-16(13-21(19)39-2)15-4-7-18(26)20(12-15)40-25(27,28)29/h3-14H,1-2H3,(H,30,36)(H,31,32,34)
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n/an/a 4n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444908
PNG
(6-((2-chloro-4'-fluoro-5-methoxy-3'-(trifluorometh...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(Cl)c(cc1OC)-c1ccc(F)c(OC(F)(F)F)c1
Show InChI InChI=1S/C24H18ClF4N5O6S/c1-30-23(35)34(22-6-4-14(12-31-22)41(36,37)33-21-7-8-39-32-21)18-11-16(25)15(10-20(18)38-2)13-3-5-17(26)19(9-13)40-24(27,28)29/h3-12H,1-2H3,(H,30,35)(H,32,33)
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n/an/a 6n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444931
PNG
(6-((3'-chloro-2,4'-difluoro-5-methoxy-4- | US10668...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ncccn1)c1cc(F)c(cc1OC)-c1ccc(F)c(c1)C(F)F
Show InChI InChI=1S/C25H20F4N6O4S/c1-30-25(36)35(22-7-5-15(13-33-22)40(37,38)34-24-31-8-3-9-32-24)20-12-19(27)16(11-21(20)39-2)14-4-6-18(26)17(10-14)23(28)29/h3-13,23H,1-2H3,(H,30,36)(H,31,32,34)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444965
PNG
(6-((1-(2-chloro-5-methoxy-3'-(trifluoromethyl)-[1,...)
Show SMILES COc1cc(c(Cl)cc1N(C(N)=O)c1ccc(cn1)S(=O)(=O)Nc1ccon1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H17ClF3N5O5S/c1-36-19-10-16(13-3-2-4-14(9-13)23(25,26)27)17(24)11-18(19)32(22(28)33)21-6-5-15(12-29-21)38(34,35)31-20-7-8-37-30-20/h2-12H,1H3,(H2,28,33)(H,30,31)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444954
PNG
(6-((2,4'-difluoro-5-methoxy-3'-(trifluoromethoxy)-...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1cccnn1)c1cc(F)c(cc1OC)-c1ccc(F)c(OC(F)(F)F)c1
Show InChI InChI=1S/C25H19F5N6O5S/c1-31-24(37)36(23-8-6-15(13-32-23)42(38,39)35-22-4-3-9-33-34-22)19-12-18(27)16(11-21(19)40-2)14-5-7-17(26)20(10-14)41-25(28,29)30/h3-13H,1-2H3,(H,31,37)(H,34,35)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444968
PNG
(6-((carbamoyl(2-chloro-3',5-dimethoxy-5'-(trifluor...)
Show SMILES COc1cc(cc(c1)C(F)(F)F)-c1cc(OC)c(cc1Cl)N(C(N)=O)c1ccc(cn1)S(=O)(=O)Nc1ccon1
Show InChI InChI=1S/C24H19ClF3N5O6S/c1-37-15-8-13(7-14(9-15)24(26,27)28)17-10-20(38-2)19(11-18(17)25)33(23(29)34)22-4-3-16(12-30-22)40(35,36)32-21-5-6-39-31-21/h3-12H,1-2H3,(H2,29,34)(H,31,32)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444937
PNG
(6-((2-chloro-4'-fluoro-5-methoxy-3'-(trifluorometh...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ncccn1)c1cc(Cl)c(cc1OC)-c1ccc(F)c(OC(F)(F)F)c1
Show InChI InChI=1S/C25H19ClF4N6O5S/c1-31-24(37)36(22-7-5-15(13-34-22)42(38,39)35-23-32-8-3-9-33-23)19-12-17(26)16(11-21(19)40-2)14-4-6-18(27)20(10-14)41-25(28,29)30/h3-13H,1-2H3,(H,31,37)(H,32,33,35)
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n/an/a 8n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444890
PNG
(6-((2-chloro-3',5-dimethoxy-5'-(trifluoromethoxy)-...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(Cl)c(cc1OC)-c1cc(OC)cc(OC(F)(F)F)c1
Show InChI InChI=1S/C25H21ClF3N5O7S/c1-30-24(35)34(23-5-4-17(13-31-23)42(36,37)33-22-6-7-40-32-22)20-12-19(26)18(11-21(20)39-3)14-8-15(38-2)10-16(9-14)41-25(27,28)29/h4-13H,1-3H3,(H,30,35)(H,32,33)
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n/an/a 9n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444897
PNG
(6-((2-chloro-4'-fluoro-5-methoxy-3'-(trifluorometh...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(Cl)c(cc1OC)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C24H18ClF4N5O5S/c1-30-23(35)34(22-6-4-14(12-31-22)40(36,37)33-21-7-8-39-32-21)19-11-17(25)15(10-20(19)38-2)13-3-5-18(26)16(9-13)24(27,28)29/h3-12H,1-2H3,(H,30,35)(H,32,33)
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n/an/a 9n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444847
PNG
(6-((3',4'-dichloro-2-fluoro-5-methoxy-4- | US10668...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(F)c(cc1OC)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C23H18Cl2FN5O5S/c1-27-23(32)31(22-6-4-14(12-28-22)37(33,34)30-21-7-8-36-29-21)19-11-18(26)15(10-20(19)35-2)13-3-5-16(24)17(25)9-13/h3-12H,1-2H3,(H,27,32)(H,29,30)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444966
PNG
(6-((carbamoyl(2,4'-dichloro-3'-fluoro-5-methoxy-4-...)
Show SMILES COc1cc(c(Cl)cc1N(C(N)=O)c1ccc(cn1)S(=O)(=O)Nc1ccon1)-c1ccc(Cl)c(F)c1
Show InChI InChI=1S/C22H16Cl2FN5O5S/c1-34-19-9-14(12-2-4-15(23)17(25)8-12)16(24)10-18(19)30(22(26)31)21-5-3-13(11-27-21)36(32,33)29-20-6-7-35-28-20/h2-11H,1H3,(H2,26,31)(H,28,29)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444878
PNG
(6-((2-chloro-5-methoxy-3'-(trifluoromethoxy)-4- | ...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(Cl)c(cc1OC)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C24H19ClF3N5O6S/c1-29-23(34)33(22-7-6-16(13-30-22)40(35,36)32-21-8-9-38-31-21)19-12-18(25)17(11-20(19)37-2)14-4-3-5-15(10-14)39-24(26,27)28/h3-13H,1-2H3,(H,29,34)(H,31,32)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444875
PNG
(6-((2-chloro-3',5-dimethoxy-5'-(trifluoromethyl)-4...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(Cl)c(cc1OC)-c1cc(OC)cc(c1)C(F)(F)F
Show InChI InChI=1S/C25H21ClF3N5O6S/c1-30-24(35)34(23-5-4-17(13-31-23)41(36,37)33-22-6-7-40-32-22)20-12-19(26)18(11-21(20)39-3)14-8-15(25(27,28)29)10-16(9-14)38-2/h4-13H,1-3H3,(H,30,35)(H,32,33)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444876
PNG
(6-((2-chloro-5-methoxy-3'-(2,2,2-trifluoroethoxy)-...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(Cl)c(cc1OC)-c1cccc(OCC(F)(F)F)c1
Show InChI InChI=1S/C25H21ClF3N5O6S/c1-30-24(35)34(23-7-6-17(13-31-23)41(36,37)33-22-8-9-40-32-22)20-12-19(26)18(11-21(20)38-2)15-4-3-5-16(10-15)39-14-25(27,28)29/h3-13H,14H2,1-2H3,(H,30,35)(H,32,33)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444865
PNG
(6-((2,4'-difluoro-5-methoxy-3'-(trifluoromethyl)-4...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(F)c(cc1OC)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C24H18F5N5O5S/c1-30-23(35)34(22-6-4-14(12-31-22)40(36,37)33-21-7-8-39-32-21)19-11-18(26)15(10-20(19)38-2)13-3-5-17(25)16(9-13)24(27,28)29/h3-12H,1-2H3,(H,30,35)(H,32,33)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444938
PNG
(6-(1-(5-Fluoro-2-methoxy-4-tetradecylphenyl)-3-met...)
Show SMILES CCCCCCCCCCCCCCc1cc(OC)c(cc1F)N(C(=O)NC)c1ccc(cn1)S(=O)(=O)Nc1ncccn1
Show InChI InChI=1S/C32H45FN6O4S/c1-4-5-6-7-8-9-10-11-12-13-14-15-17-25-22-29(43-3)28(23-27(25)33)39(32(40)34-2)30-19-18-26(24-37-30)44(41,42)38-31-35-20-16-21-36-31/h16,18-24H,4-15,17H2,1-3H3,(H,34,40)(H,35,36,38)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444949
PNG
(6-((2-chloro-4'-fluoro-5-methoxy-3'-(trifluorometh...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1cnsn1)c1cc(Cl)c(cc1OC)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C23H17ClF4N6O4S2/c1-29-22(35)34(21-6-4-13(10-30-21)40(36,37)33-20-11-31-39-32-20)18-9-16(24)14(8-19(18)38-2)12-3-5-17(25)15(7-12)23(26,27)28/h3-11H,1-2H3,(H,29,35)(H,32,33)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444926
PNG
(6-((2,4'-difluoro-5-methoxy-3'-(trifluoromethoxy)-...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ncccn1)c1cc(F)c(cc1OC)-c1ccc(F)c(OC(F)(F)F)c1
Show InChI InChI=1S/C25H19F5N6O5S/c1-31-24(37)36(22-7-5-15(13-34-22)42(38,39)35-23-32-8-3-9-33-23)19-12-18(27)16(11-21(19)40-2)14-4-6-17(26)20(10-14)41-25(28,29)30/h3-13H,1-2H3,(H,31,37)(H,32,33,35)
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n/an/a 14n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444848
PNG
(6-((4'-chloro-2-fluoro-5-methoxy-3'-(trifluorometh...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(F)c(cc1OC)-c1ccc(Cl)c(c1)C(F)(F)F
Show InChI InChI=1S/C24H18ClF4N5O5S/c1-30-23(35)34(22-6-4-14(12-31-22)40(36,37)33-21-7-8-39-32-21)19-11-18(26)15(10-20(19)38-2)13-3-5-17(25)16(9-13)24(27,28)29/h3-12H,1-2H3,(H,30,35)(H,32,33)
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n/an/a 14n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444871
PNG
(6-((2,3'-dichloro-5,5'-dimethoxy-4- | US10668067, ...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(Cl)c(cc1OC)-c1cc(Cl)cc(OC)c1
Show InChI InChI=1S/C24H21Cl2N5O6S/c1-27-24(32)31(23-5-4-17(13-28-23)38(33,34)30-22-6-7-37-29-22)20-12-19(26)18(11-21(20)36-3)14-8-15(25)10-16(9-14)35-2/h4-13H,1-3H3,(H,27,32)(H,29,30)
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n/an/a 14n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444969
PNG
(6-((carbamoyl(2-chloro-5-methoxy-3'-(2,2,2-trifluo...)
Show SMILES COc1cc(c(Cl)cc1N(C(N)=O)c1ccc(cn1)S(=O)(=O)Nc1ccon1)-c1cccc(OCC(F)(F)F)c1
Show InChI InChI=1S/C24H19ClF3N5O6S/c1-37-20-10-17(14-3-2-4-15(9-14)38-13-24(26,27)28)18(25)11-19(20)33(23(29)34)22-6-5-16(12-30-22)40(35,36)32-21-7-8-39-31-21/h2-12H,13H2,1H3,(H2,29,34)(H,31,32)
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n/an/a 16n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444864
PNG
(6-((3'-chloro-2,4'-difluoro-5,5'-dimethoxy-4- | US...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(F)c(cc1OC)-c1cc(Cl)c(F)c(OC)c1
Show InChI InChI=1S/C24H20ClF2N5O6S/c1-28-24(33)32(22-5-4-14(12-29-22)39(34,35)31-21-6-7-38-30-21)18-11-17(26)15(10-19(18)36-2)13-8-16(25)23(27)20(9-13)37-3/h4-12H,1-3H3,(H,28,33)(H,30,31)
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n/an/a 16n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444870
PNG
(6-((2-chloro-5-methoxy-3'-(trifluoromethyl)-4- | U...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(Cl)c(cc1OC)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H19ClF3N5O5S/c1-29-23(34)33(22-7-6-16(13-30-22)39(35,36)32-21-8-9-38-31-21)19-12-18(25)17(11-20(19)37-2)14-4-3-5-15(10-14)24(26,27)28/h3-13H,1-2H3,(H,29,34)(H,31,32)
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n/an/a 16n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444936
PNG
(6-((4'-fluoro-3-methoxy-3'-(trifluoromethyl)-4- | ...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ncccn1)c1ccc(cc1OC)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C25H20F4N6O4S/c1-30-24(36)35(22-9-6-17(14-33-22)40(37,38)34-23-31-10-3-11-32-23)20-8-5-16(13-21(20)39-2)15-4-7-19(26)18(12-15)25(27,28)29/h3-14H,1-2H3,(H,30,36)(H,31,32,34)
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n/an/a 17n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444894
PNG
(6-((2-chloro-2'-fluoro-5-methoxy-5'-(trifluorometh...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(Cl)c(cc1OC)-c1cc(ccc1F)C(F)(F)F
Show InChI InChI=1S/C24H18ClF4N5O5S/c1-30-23(35)34(22-6-4-14(12-31-22)40(36,37)33-21-7-8-39-32-21)19-11-17(25)15(10-20(19)38-2)16-9-13(24(27,28)29)3-5-18(16)26/h3-12H,1-2H3,(H,30,35)(H,32,33)
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n/an/a 17n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444851
PNG
(6-((2-fluoro-5-methoxy-3'-(trifluoromethoxy)-4- | ...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(F)c(cc1OC)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C24H19F4N5O6S/c1-29-23(34)33(22-7-6-16(13-30-22)40(35,36)32-21-8-9-38-31-21)19-12-18(25)17(11-20(19)37-2)14-4-3-5-15(10-14)39-24(26,27)28/h3-13H,1-2H3,(H,29,34)(H,31,32)
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n/an/a 17n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444955
PNG
(6-((2,4'-difluoro-5-methoxy-3'-(trifluoromethoxy)-...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ncco1)c1cc(F)c(cc1OC)-c1ccc(F)c(OC(F)(F)F)c1
Show InChI InChI=1S/C24H18F5N5O6S/c1-30-23(35)34(21-6-4-14(12-32-21)41(36,37)33-22-31-7-8-39-22)18-11-17(26)15(10-20(18)38-2)13-3-5-16(25)19(9-13)40-24(27,28)29/h3-12H,1-2H3,(H,30,35)(H,31,33)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444921
PNG
(6-((2-fluoro-3',5-dimethoxy-5'-(trifluoromethyl)-4...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ncccn1)c1cc(F)c(cc1OC)-c1cc(OC)cc(c1)C(F)(F)F
Show InChI InChI=1S/C26H22F4N6O5S/c1-31-25(37)36(23-6-5-18(14-34-23)42(38,39)35-24-32-7-4-8-33-24)21-13-20(27)19(12-22(21)41-3)15-9-16(26(28,29)30)11-17(10-15)40-2/h4-14H,1-3H3,(H,31,37)(H,32,33,35)
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n/an/a 18n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444930
PNG
(6-((3′-chloro-2,4′-difluoro-5-methoxy-...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ncccn1)c1cc(F)c(cc1OC)-c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C24H19ClF2N6O4S/c1-28-24(34)33(22-7-5-15(13-31-22)38(35,36)32-23-29-8-3-9-30-23)20-12-19(27)16(11-21(20)37-2)14-4-6-18(26)17(25)10-14/h3-13H,1-2H3,(H,28,34)(H,29,30,32)
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n/an/a 18n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444846
PNG
(6-((2-fluoro-3',5-dimethoxy-5'-(trifluoromethyl)-4...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(F)c(cc1OC)-c1cc(OC)cc(c1)C(F)(F)F
Show InChI InChI=1S/C25H21F4N5O6S/c1-30-24(35)34(23-5-4-17(13-31-23)41(36,37)33-22-6-7-40-32-22)20-12-19(26)18(11-21(20)39-3)14-8-15(25(27,28)29)10-16(9-14)38-2/h4-13H,1-3H3,(H,30,35)(H,32,33)
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n/an/a 18n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444844
PNG
(6-((2-fluoro-3',5-dimethoxy-5'-(trifluoromethoxy)-...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(F)c(cc1OC)-c1cc(OC)cc(OC(F)(F)F)c1
Show InChI InChI=1S/C25H21F4N5O7S/c1-30-24(35)34(23-5-4-17(13-31-23)42(36,37)33-22-6-7-40-32-22)20-12-19(26)18(11-21(20)39-3)14-8-15(38-2)10-16(9-14)41-25(27,28)29/h4-13H,1-3H3,(H,30,35)(H,32,33)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444899
PNG
(6-((2,3'-dichloro-4'-fluoro-5-methoxy-4- | US10668...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(Cl)c(cc1OC)-c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C23H18Cl2FN5O5S/c1-27-23(32)31(22-6-4-14(12-28-22)37(33,34)30-21-7-8-36-29-21)19-11-16(24)15(10-20(19)35-2)13-3-5-18(26)17(25)9-13/h3-12H,1-2H3,(H,27,32)(H,29,30)
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n/an/a 19n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444895
PNG
(6-((2-chloro-2',5-dimethoxy-5'-(trifluoromethoxy)-...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(Cl)c(cc1OC)-c1cc(OC(F)(F)F)ccc1OC
Show InChI InChI=1S/C25H21ClF3N5O7S/c1-30-24(35)34(23-7-5-15(13-31-23)42(36,37)33-22-8-9-40-32-22)19-12-18(26)16(11-21(19)39-3)17-10-14(41-25(27,28)29)4-6-20(17)38-2/h4-13H,1-3H3,(H,30,35)(H,32,33)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444866
PNG
(6-((2,4'-difluoro-5-methoxy-3'-(trifluoromethoxy)-...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(F)c(cc1OC)-c1ccc(F)c(OC(F)(F)F)c1
Show InChI InChI=1S/C24H18F5N5O6S/c1-30-23(35)34(22-6-4-14(12-31-22)41(36,37)33-21-7-8-39-32-21)18-11-17(26)15(10-20(18)38-2)13-3-5-16(25)19(9-13)40-24(27,28)29/h3-12H,1-2H3,(H,30,35)(H,32,33)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444868
PNG
(6-((2,4'-dichloro-5-methoxy-3'-methyl-4- | US10668...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(Cl)c(cc1OC)-c1ccc(Cl)c(C)c1
Show InChI InChI=1S/C24H21Cl2N5O5S/c1-14-10-15(4-6-18(14)25)17-11-21(35-3)20(12-19(17)26)31(24(32)27-2)23-7-5-16(13-28-23)37(33,34)30-22-8-9-36-29-22/h4-13H,1-3H3,(H,27,32)(H,29,30)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444900
PNG
(6-((2,3'-dichloro-5-methoxy-4'-methyl-4- | US10668...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(Cl)c(cc1OC)-c1ccc(C)c(Cl)c1
Show InChI InChI=1S/C24H21Cl2N5O5S/c1-14-4-5-15(10-18(14)25)17-11-21(35-3)20(12-19(17)26)31(24(32)27-2)23-7-6-16(13-28-23)37(33,34)30-22-8-9-36-29-22/h4-13H,1-3H3,(H,27,32)(H,29,30)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444951
PNG
(6-((2-chloro-4'-fluoro-5-methoxy-3'-(trifluorometh...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ncco1)c1cc(Cl)c(cc1OC)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C24H18ClF4N5O5S/c1-30-23(35)34(21-6-4-14(12-32-21)40(36,37)33-22-31-7-8-39-22)19-11-17(25)15(10-20(19)38-2)13-3-5-18(26)16(9-13)24(27,28)29/h3-12H,1-2H3,(H,30,35)(H,31,33)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444877
PNG
(6-((2-chloro-3'-cyclopropyl-5-methoxy-4- | US10668...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(Cl)c(cc1OC)-c1cccc(c1)C1CC1
Show InChI InChI=1S/C26H24ClN5O5S/c1-28-26(33)32(25-9-8-19(15-29-25)38(34,35)31-24-10-11-37-30-24)22-14-21(27)20(13-23(22)36-2)18-5-3-4-17(12-18)16-6-7-16/h3-5,8-16H,6-7H2,1-2H3,(H,28,33)(H,30,31)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444907
PNG
(6-((2-chloro-3',4'-difluoro-5,5'-dimethoxy-4- | US...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(Cl)c(cc1OC)-c1cc(F)c(F)c(OC)c1
Show InChI InChI=1S/C24H20ClF2N5O6S/c1-28-24(33)32(22-5-4-14(12-29-22)39(34,35)31-21-6-7-38-30-21)18-11-16(25)15(10-19(18)36-2)13-8-17(26)23(27)20(9-13)37-3/h4-12H,1-3H3,(H,28,33)(H,30,31)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444896
PNG
(6-((2-chloro-4'-fluoro-5-methoxy-3'-(2,2,2-trifluo...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(Cl)c(cc1OC)-c1ccc(F)c(OCC(F)(F)F)c1
Show InChI InChI=1S/C25H20ClF4N5O6S/c1-31-24(36)35(23-6-4-15(12-32-23)42(37,38)34-22-7-8-41-33-22)19-11-17(26)16(10-21(19)39-2)14-3-5-18(27)20(9-14)40-13-25(28,29)30/h3-12H,13H2,1-2H3,(H,31,36)(H,33,34)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444953
PNG
(6-((2-chloro-4'-fluoro-5-methoxy-3'-(trifluorometh...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccncn1)c1cc(Cl)c(cc1OC)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C25H19ClF4N6O4S/c1-31-24(37)36(23-6-4-15(12-33-23)41(38,39)35-22-7-8-32-13-34-22)20-11-18(26)16(10-21(20)40-2)14-3-5-19(27)17(9-14)25(28,29)30/h3-13H,1-2H3,(H,31,37)(H,32,34,35)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444934
PNG
(6-((5-chloro-2-methoxy-4-(2-methoxy-6-((trifluorom...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1cccnn1)c1cc(Cl)c(cc1OC)-c1cc(OC)nc(c1)C(F)(F)F
Show InChI InChI=1S/C25H21ClF3N7O5S/c1-30-24(37)36(22-7-6-15(13-31-22)42(38,39)35-21-5-4-8-32-34-21)18-12-17(26)16(11-19(18)40-2)14-9-20(25(27,28)29)33-23(10-14)41-3/h4-13H,1-3H3,(H,30,37)(H,34,35)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444952
PNG
(6-((2-chloro-4'-fluoro-5-methoxy-3'-(trifluorometh...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccnc(C)n1)c1cc(Cl)c(cc1OC)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C26H21ClF4N6O4S/c1-14-33-9-8-23(35-14)36-42(39,40)16-5-7-24(34-13-16)37(25(38)32-2)21-12-19(27)17(11-22(21)41-3)15-4-6-20(28)18(10-15)26(29,30)31/h4-13H,1-3H3,(H,32,38)(H,33,35,36)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444873
PNG
(6-((2,5'-dichloro-5-methoxy-2'-methyl-4- | US10668...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(Cl)c(cc1OC)-c1cc(Cl)ccc1C
Show InChI InChI=1S/C24H21Cl2N5O5S/c1-14-4-5-15(25)10-17(14)18-11-21(35-3)20(12-19(18)26)31(24(32)27-2)23-7-6-16(13-28-23)37(33,34)30-22-8-9-36-29-22/h4-13H,1-3H3,(H,27,32)(H,29,30)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444888
PNG
(6-((2-chloro-3'-fluoro-5-methoxy-5'-(trifluorometh...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(Cl)c(cc1OC)-c1cc(F)cc(c1)C(F)(F)F
Show InChI InChI=1S/C24H18ClF4N5O5S/c1-30-23(35)34(22-4-3-16(12-31-22)40(36,37)33-21-5-6-39-32-21)19-11-18(25)17(10-20(19)38-2)13-7-14(24(27,28)29)9-15(26)8-13/h3-12H,1-2H3,(H,30,35)(H,32,33)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444869
PNG
(6-((2,3'-dichloro-5'-fluoro-5-methoxy-4- | US10668...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(Cl)c(cc1OC)-c1cc(F)cc(Cl)c1
Show InChI InChI=1S/C23H18Cl2FN5O5S/c1-27-23(32)31(22-4-3-16(12-28-22)37(33,34)30-21-5-6-36-29-21)19-11-18(25)17(10-20(19)35-2)13-7-14(24)9-15(26)8-13/h3-12H,1-2H3,(H,27,32)(H,29,30)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444948
PNG
(6-((2-chloro-4'-fluoro-5-methoxy-3'-(trifluorometh...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ncccn1)c1cc(Cl)c(cc1OC)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C25H19ClF4N6O4S/c1-31-24(37)36(22-7-5-15(13-34-22)41(38,39)35-23-32-8-3-9-33-23)20-12-18(26)16(11-21(20)40-2)14-4-6-19(27)17(10-14)25(28,29)30/h3-13H,1-2H3,(H,31,37)(H,32,33,35)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444902
PNG
(6-((2,4'-dichloro-3'-fluoro-5-methoxy-4- | US10668...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(Cl)c(cc1OC)-c1ccc(Cl)c(F)c1
Show InChI InChI=1S/C23H18Cl2FN5O5S/c1-27-23(32)31(22-6-4-14(12-28-22)37(33,34)30-21-7-8-36-29-21)19-11-17(25)15(10-20(19)35-2)13-3-5-16(24)18(26)9-13/h3-12H,1-2H3,(H,27,32)(H,29,30)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444881
PNG
(6-((5-chloro-2-methoxy-4-(2-methoxy-6-((trifluorom...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(Cl)c(cc1OC)-c1cc(OC)nc(c1)C(F)(F)F
Show InChI InChI=1S/C24H20ClF3N6O6S/c1-29-23(35)34(21-5-4-14(12-30-21)41(36,37)33-20-6-7-40-32-20)17-11-16(25)15(10-18(17)38-2)13-8-19(24(26,27)28)31-22(9-13)39-3/h4-12H,1-3H3,(H,29,35)(H,32,33)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444943
PNG
(6-((2-chloro-4'-fluoro-5-methoxy-3'-(2,2,2-trifluo...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1cnsn1)c1cc(Cl)c(cc1OC)-c1ccc(F)c(OCC(F)(F)F)c1
Show InChI InChI=1S/C24H19ClF4N6O5S2/c1-30-23(36)35(22-6-4-14(10-31-22)42(37,38)34-21-11-32-41-33-21)18-9-16(25)15(8-20(18)39-2)13-3-5-17(26)19(7-13)40-12-24(27,28)29/h3-11H,12H2,1-2H3,(H,30,36)(H,33,34)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444856
PNG
(6-((3'-chloro-2-fluoro-5-methoxy-4'-methyl-4- | US...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(F)c(cc1OC)-c1ccc(C)c(Cl)c1
Show InChI InChI=1S/C24H21ClFN5O5S/c1-14-4-5-15(10-18(14)25)17-11-21(35-3)20(12-19(17)26)31(24(32)27-2)23-7-6-16(13-28-23)37(33,34)30-22-8-9-36-29-22/h4-13H,1-3H3,(H,27,32)(H,29,30)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444967
PNG
(6-((carbamoyl(2,3'-dichloro-5'-cyano-5-methoxy-4- ...)
Show SMILES COc1cc(c(Cl)cc1N(C(N)=O)c1ccc(cn1)S(=O)(=O)Nc1ccon1)-c1cc(Cl)cc(c1)C#N
Show InChI InChI=1S/C23H16Cl2N6O5S/c1-35-20-9-17(14-6-13(11-26)7-15(24)8-14)18(25)10-19(20)31(23(27)32)22-3-2-16(12-28-22)37(33,34)30-21-4-5-36-29-21/h2-10,12H,1H3,(H2,27,32)(H,29,30)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444891
PNG
(6-((2-chloro-3',4',5'-trifluoro-5-methoxy-4- | US1...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(Cl)c(cc1OC)-c1cc(F)c(F)c(F)c1
Show InChI InChI=1S/C23H17ClF3N5O5S/c1-28-23(33)32(21-4-3-13(11-29-21)38(34,35)31-20-5-6-37-30-20)18-10-15(24)14(9-19(18)36-2)12-7-16(25)22(27)17(26)8-12/h3-11H,1-2H3,(H,28,33)(H,30,31)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444879
PNG
(6-((5-chloro-2-methoxy-4-(2-methoxy-5-(trifluorome...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(Cl)c(cc1OC)-c1cc(cnc1OC)C(F)(F)F
Show InChI InChI=1S/C24H20ClF3N6O6S/c1-29-23(35)34(21-5-4-14(12-30-21)41(36,37)33-20-6-7-40-32-20)18-10-17(25)15(9-19(18)38-2)16-8-13(24(26,27)28)11-31-22(16)39-3/h4-12H,1-3H3,(H,29,35)(H,32,33)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444922
PNG
(6-((3',4'-dichloro-2-fluoro-5-methoxy-4- | US10668...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ncccn1)c1cc(F)c(cc1OC)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C24H19Cl2FN6O4S/c1-28-24(34)33(22-7-5-15(13-31-22)38(35,36)32-23-29-8-3-9-30-23)20-12-19(27)16(11-21(20)37-2)14-4-6-17(25)18(26)10-14/h3-13H,1-2H3,(H,28,34)(H,29,30,32)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444924
PNG
(6-((2,4'-difluoro-5-methoxy-3'-(trifluoromethyl)-4...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ncccn1)c1cc(F)c(cc1OC)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C25H19F5N6O4S/c1-31-24(37)36(22-7-5-15(13-34-22)41(38,39)35-23-32-8-3-9-33-23)20-12-19(27)16(11-21(20)40-2)14-4-6-18(26)17(10-14)25(28,29)30/h3-13H,1-2H3,(H,31,37)(H,32,33,35)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM50466969
PNG
(CHEMBL4287442 | US10668067, Example 1-4)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(F)c(cc1OC)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H19F4N5O5S/c1-29-23(34)33(22-7-6-16(13-30-22)39(35,36)32-21-8-9-38-31-21)19-12-18(25)17(11-20(19)37-2)14-4-3-5-15(10-14)24(26,27)28/h3-13H,1-2H3,(H,29,34)(H,31,32)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444942
PNG
(6-(1-(2-chloro-4′-fluoro-5-methoxy-3′-...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ncccn1)c1cc(Cl)c(cc1OC)-c1ccc(F)c(OCC(F)(F)F)c1
Show InChI InChI=1S/C26H21ClF4N6O5S/c1-32-25(38)37(23-7-5-16(13-35-23)43(39,40)36-24-33-8-3-9-34-24)20-12-18(27)17(11-22(20)41-2)15-4-6-19(28)21(10-15)42-14-26(29,30)31/h3-13H,14H2,1-2H3,(H,32,38)(H,33,34,36)
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n/an/a 33n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444906
PNG
(6-((2-chloro-3'-ethoxy-4'-fluoro-5-methoxy-4- | US...)
Show SMILES CCOc1cc(ccc1F)-c1cc(OC)c(cc1Cl)N(C(=O)NC)c1ccc(cn1)S(=O)(=O)Nc1ccon1
Show InChI InChI=1S/C25H23ClFN5O6S/c1-4-37-21-11-15(5-7-19(21)27)17-12-22(36-3)20(13-18(17)26)32(25(33)28-2)24-8-6-16(14-29-24)39(34,35)31-23-9-10-38-30-23/h5-14H,4H2,1-3H3,(H,28,33)(H,30,31)
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n/an/a 34n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444860
PNG
(6-((3'-chloro-2,4'-difluoro-5-methoxy-4- | US10668...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(F)c(cc1OC)-c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C23H18ClF2N5O5S/c1-27-23(32)31(22-6-4-14(12-28-22)37(33,34)30-21-7-8-36-29-21)19-11-18(26)15(10-20(19)35-2)13-3-5-17(25)16(24)9-13/h3-12H,1-2H3,(H,27,32)(H,29,30)
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n/an/a 37n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444919
PNG
(6-((4'-chloro-2-fluoro-5-methoxy-3'-methyl-4- | US...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ncccn1)c1cc(F)c(cc1OC)-c1ccc(Cl)c(C)c1
Show InChI InChI=1S/C25H22ClFN6O4S/c1-15-11-16(5-7-19(15)26)18-12-22(37-3)21(13-20(18)27)33(25(34)28-2)23-8-6-17(14-31-23)38(35,36)32-24-29-9-4-10-30-24/h4-14H,1-3H3,(H,28,34)(H,29,30,32)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444927
PNG
(6-((2,4'-difluoro-5-methoxy-3'-(2,2,2-trifluoroeth...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ncccn1)c1cc(F)c(cc1OC)-c1ccc(F)c(OCC(F)(F)F)c1
Show InChI InChI=1S/C26H21F5N6O5S/c1-32-25(38)37(23-7-5-16(13-35-23)43(39,40)36-24-33-8-3-9-34-24)20-12-19(28)17(11-22(20)41-2)15-4-6-18(27)21(10-15)42-14-26(29,30)31/h3-13H,14H2,1-2H3,(H,32,38)(H,33,34,36)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444839
PNG
(6-((2-fluoro-5-methoxy-3'-(trifluoromethyl)-4- | U...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1cccnn1)c1cc(F)c(cc1OC)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H20F4N6O4S/c1-30-24(36)35(23-9-8-17(14-31-23)40(37,38)34-22-7-4-10-32-33-22)20-13-19(26)18(12-21(20)39-2)15-5-3-6-16(11-15)25(27,28)29/h3-14H,1-2H3,(H,30,36)(H,33,34)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444872
PNG
(6-((2,4'-dichloro-3',5-dimethoxy-4- | US10668067, ...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(Cl)c(cc1OC)-c1ccc(Cl)c(OC)c1
Show InChI InChI=1S/C24H21Cl2N5O6S/c1-27-24(32)31(23-7-5-15(13-28-23)38(33,34)30-22-8-9-37-29-22)19-12-18(26)16(11-21(19)36-3)14-4-6-17(25)20(10-14)35-2/h4-13H,1-3H3,(H,27,32)(H,29,30)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444928
PNG
(6-((4'-chloro-2-fluoro-5-methoxy-3'-(trifluorometh...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ncccn1)c1cc(F)c(cc1OC)-c1ccc(Cl)c(c1)C(F)(F)F
Show InChI InChI=1S/C25H19ClF4N6O4S/c1-31-24(37)36(22-7-5-15(13-34-22)41(38,39)35-23-32-8-3-9-33-23)20-12-19(27)16(11-21(20)40-2)14-4-6-18(26)17(10-14)25(28,29)30/h3-13H,1-2H3,(H,31,37)(H,32,33,35)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444850
PNG
(6-((3'-cyclopropyl-2-fluoro-5-methoxy-4- | US10668...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(F)c(cc1OC)-c1cccc(c1)C1CC1
Show InChI InChI=1S/C26H24FN5O5S/c1-28-26(33)32(25-9-8-19(15-29-25)38(34,35)31-24-10-11-37-30-24)22-14-21(27)20(13-23(22)36-2)18-5-3-4-17(12-18)16-6-7-16/h3-5,8-16H,6-7H2,1-2H3,(H,28,33)(H,30,31)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444885
PNG
(6-((2-chloro-3',5-dimethoxy-4'-(trifluoromethyl)-4...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(Cl)c(cc1OC)-c1ccc(c(OC)c1)C(F)(F)F
Show InChI InChI=1S/C25H21ClF3N5O6S/c1-30-24(35)34(23-7-5-15(13-31-23)41(36,37)33-22-8-9-40-32-22)19-12-18(26)16(11-21(19)39-3)14-4-6-17(25(27,28)29)20(10-14)38-2/h4-13H,1-3H3,(H,30,35)(H,32,33)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444858
PNG
(6-((3'-chloro-2-fluoro-5-methoxy-5'-methyl-4- | US...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(F)c(cc1OC)-c1cc(C)cc(Cl)c1
Show InChI InChI=1S/C24H21ClFN5O5S/c1-14-8-15(10-16(25)9-14)18-11-21(35-3)20(12-19(18)26)31(24(32)27-2)23-5-4-17(13-28-23)37(33,34)30-22-6-7-36-29-22/h4-13H,1-3H3,(H,27,32)(H,29,30)
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n/an/a 47n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444892
PNG
(6-((2,3'-dichloro-5'-cyano-5-methoxy-4- | US106680...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(Cl)c(cc1OC)-c1cc(Cl)cc(c1)C#N
Show InChI InChI=1S/C24H18Cl2N6O5S/c1-28-24(33)32(23-4-3-17(13-29-23)38(34,35)31-22-5-6-37-30-22)20-11-19(26)18(10-21(20)36-2)15-7-14(12-27)8-16(25)9-15/h3-11,13H,1-2H3,(H,28,33)(H,30,31)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444889
PNG
(6-((2-chloro-4'-fluoro-3',5-dimethoxy-5'-methyl-4-...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(Cl)c(cc1OC)-c1cc(C)c(F)c(OC)c1
Show InChI InChI=1S/C25H23ClFN5O6S/c1-14-9-15(10-21(37-4)24(14)27)17-11-20(36-3)19(12-18(17)26)32(25(33)28-2)23-6-5-16(13-29-23)39(34,35)31-22-7-8-38-30-22/h5-13H,1-4H3,(H,28,33)(H,30,31)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444859
PNG
(6-((4'-chloro-2,3'-difluoro-5-methoxy-4- | US10668...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(F)c(cc1OC)-c1ccc(Cl)c(F)c1
Show InChI InChI=1S/C23H18ClF2N5O5S/c1-27-23(32)31(22-6-4-14(12-28-22)37(33,34)30-21-7-8-36-29-21)19-11-17(25)15(10-20(19)35-2)13-3-5-16(24)18(26)9-13/h3-12H,1-2H3,(H,27,32)(H,29,30)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444842
PNG
(6-((3'-chloro-2-fluoro-5,5'-dimethoxy-4- | US10668...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(F)c(cc1OC)-c1cc(Cl)cc(OC)c1
Show InChI InChI=1S/C24H21ClFN5O6S/c1-27-24(32)31(23-5-4-17(13-28-23)38(33,34)30-22-6-7-37-29-22)20-12-19(26)18(11-21(20)36-3)14-8-15(25)10-16(9-14)35-2/h4-13H,1-3H3,(H,27,32)(H,29,30)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444947
PNG
(6-((2-chloro-4'-fluoro-5-methoxy-3'-(2,2,2-trifluo...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccncn1)c1cc(Cl)c(cc1OC)-c1ccc(F)c(OCC(F)(F)F)c1
Show InChI InChI=1S/C26H21ClF4N6O5S/c1-32-25(38)37(24-6-4-16(12-34-24)43(39,40)36-23-7-8-33-14-35-23)20-11-18(27)17(10-22(20)41-2)15-3-5-19(28)21(9-15)42-13-26(29,30)31/h3-12,14H,13H2,1-2H3,(H,32,38)(H,33,35,36)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444893
PNG
(6-((2,4'-dichloro-3'-cyano-5-methoxy-4- | US106680...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(Cl)c(cc1OC)-c1ccc(Cl)c(c1)C#N
Show InChI InChI=1S/C24H18Cl2N6O5S/c1-28-24(33)32(23-6-4-16(13-29-23)38(34,35)31-22-7-8-37-30-22)20-11-19(26)17(10-21(20)36-2)14-3-5-18(25)15(9-14)12-27/h3-11,13H,1-2H3,(H,28,33)(H,30,31)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444909
PNG
(6-((2,4'-dichloro-5-methoxy-4-biphenylyl)(methylca...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(Cl)c(cc1OC)-c1ccc(Cl)cc1
Show InChI InChI=1S/C23H19Cl2N5O5S/c1-26-23(31)30(22-8-7-16(13-27-22)36(32,33)29-21-9-10-35-28-21)19-12-18(25)17(11-20(19)34-2)14-3-5-15(24)6-4-14/h3-13H,1-2H3,(H,26,31)(H,28,29)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444950
PNG
(6-((2-chloro-4'-fluoro-5-methoxy-3'-(trifluorometh...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1cccc(F)n1)c1cc(Cl)c(cc1OC)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C26H19ClF5N5O4S/c1-33-25(38)37(24-9-7-15(13-34-24)42(39,40)36-23-5-3-4-22(29)35-23)20-12-18(27)16(11-21(20)41-2)14-6-8-19(28)17(10-14)26(30,31)32/h3-13H,1-2H3,(H,33,38)(H,35,36)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444945
PNG
(6-((2-chloro-4'-fluoro-5-methoxy-3'-(2,2,2-trifluo...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ncco1)c1cc(Cl)c(cc1OC)-c1ccc(F)c(OCC(F)(F)F)c1
Show InChI InChI=1S/C25H20ClF4N5O6S/c1-31-24(36)35(22-6-4-15(12-33-22)42(37,38)34-23-32-7-8-40-23)19-11-17(26)16(10-21(19)39-2)14-3-5-18(27)20(9-14)41-13-25(28,29)30/h3-12H,13H2,1-2H3,(H,31,36)(H,32,34)
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n/an/a 53n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444932
PNG
(6-((2-chloro-4'-fluoro-5-methoxy-3'-(2,2,2-trifluo...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1cccnn1)c1cc(Cl)c(cc1OC)-c1ccc(F)c(OCC(F)(F)F)c1
Show InChI InChI=1S/C26H21ClF4N6O5S/c1-32-25(38)37(24-8-6-16(13-33-24)43(39,40)36-23-4-3-9-34-35-23)20-12-18(27)17(11-22(20)41-2)15-5-7-19(28)21(10-15)42-14-26(29,30)31/h3-13H,14H2,1-2H3,(H,32,38)(H,35,36)
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n/an/a 54n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444904
PNG
(6-((2-chloro-3',4'-difluoro-5-methoxy-4- | US10668...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(Cl)c(cc1OC)-c1ccc(F)c(F)c1
Show InChI InChI=1S/C23H18ClF2N5O5S/c1-27-23(32)31(22-6-4-14(12-28-22)37(33,34)30-21-7-8-36-29-21)19-11-16(24)15(10-20(19)35-2)13-3-5-17(25)18(26)9-13/h3-12H,1-2H3,(H,27,32)(H,29,30)
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n/an/a 54n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444832
PNG
(6-(1-(4′-chloro-2-fluoro-5-methoxy-3′-...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(F)c(cc1OC)-c1ccc(Cl)c(C)c1
Show InChI InChI=1S/C24H21ClFN5O5S/c1-14-10-15(4-6-18(14)25)17-11-21(35-3)20(12-19(17)26)31(24(32)27-2)23-7-5-16(13-28-23)37(33,34)30-22-8-9-36-29-22/h4-13H,1-3H3,(H,27,32)(H,29,30)
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n/an/a 57n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444867
PNG
(6-((2-chloro-4'-fluoro-5-methoxy-3'-methyl-4- | US...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(Cl)c(cc1OC)-c1ccc(F)c(C)c1
Show InChI InChI=1S/C24H21ClFN5O5S/c1-14-10-15(4-6-19(14)26)17-11-21(35-3)20(12-18(17)25)31(24(32)27-2)23-7-5-16(13-28-23)37(33,34)30-22-8-9-36-29-22/h4-13H,1-3H3,(H,27,32)(H,29,30)
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n/an/a 58n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444905
PNG
(6-((2-chloro-4'-fluoro-3',5,5'-trimethoxy-4- | US1...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(Cl)c(cc1OC)-c1cc(OC)c(F)c(OC)c1
Show InChI InChI=1S/C25H23ClFN5O7S/c1-28-25(33)32(23-6-5-15(13-29-23)40(34,35)31-22-7-8-39-30-22)18-12-17(26)16(11-19(18)36-2)14-9-20(37-3)24(27)21(10-14)38-4/h5-13H,1-4H3,(H,28,33)(H,30,31)
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n/an/a 59n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444855
PNG
(6-((2,4'-difluoro-5-methoxy-3'-methyl-4- | US10668...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(F)c(cc1OC)-c1ccc(F)c(C)c1
Show InChI InChI=1S/C24H21F2N5O5S/c1-14-10-15(4-6-18(14)25)17-11-21(35-3)20(12-19(17)26)31(24(32)27-2)23-7-5-16(13-28-23)37(33,34)30-22-8-9-36-29-22/h4-13H,1-3H3,(H,27,32)(H,29,30)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444923
PNG
(6-((2-fluoro-5-methoxy-3'-(trifluoromethoxy)-4- | ...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ncccn1)c1cc(F)c(cc1OC)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C25H20F4N6O5S/c1-30-24(36)35(22-8-7-17(14-33-22)41(37,38)34-23-31-9-4-10-32-23)20-13-19(26)18(12-21(20)39-2)15-5-3-6-16(11-15)40-25(27,28)29/h3-14H,1-2H3,(H,30,36)(H,31,32,34)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444939
PNG
(6-(1-(2,4′-difluoro-5-methoxy-3′-(trif...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1nocc1C)c1cc(F)c(cc1OC)-c1ccc(F)c(OC(F)(F)F)c1
Show InChI InChI=1S/C25H20F5N5O6S/c1-13-12-40-33-23(13)34-42(37,38)15-5-7-22(32-11-15)35(24(36)31-2)19-10-18(27)16(9-21(19)39-3)14-4-6-17(26)20(8-14)41-25(28,29)30/h4-12H,1-3H3,(H,31,36)(H,33,34)
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n/an/a 63.5n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444901
PNG
(6-((2-chloro-3'-fluoro-5-methoxy-4'-methyl-4- | US...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(Cl)c(cc1OC)-c1ccc(C)c(F)c1
Show InChI InChI=1S/C24H21ClFN5O5S/c1-14-4-5-15(10-19(14)26)17-11-21(35-3)20(12-18(17)25)31(24(32)27-2)23-7-6-16(13-28-23)37(33,34)30-22-8-9-36-29-22/h4-13H,1-3H3,(H,27,32)(H,29,30)
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n/an/a 64n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444884
PNG
(6-((2-chloro-5-methoxy-4'-(trifluoromethyl)-4- | U...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(Cl)c(cc1OC)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C24H19ClF3N5O5S/c1-29-23(34)33(22-8-7-16(13-30-22)39(35,36)32-21-9-10-38-31-21)19-12-18(25)17(11-20(19)37-2)14-3-5-15(6-4-14)24(26,27)28/h3-13H,1-2H3,(H,29,34)(H,31,32)
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n/an/a 65n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444912
PNG
(6-((4'-chloro-3-methoxy-3'-methyl-4- | US10668067,...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1ccc(cc1OC)-c1ccc(Cl)c(C)c1
Show InChI InChI=1S/C24H22ClN5O5S/c1-15-12-16(4-7-19(15)25)17-5-8-20(21(13-17)34-3)30(24(31)26-2)23-9-6-18(14-27-23)36(32,33)29-22-10-11-35-28-22/h4-14H,1-3H3,(H,26,31)(H,28,29)
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n/an/a 65n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444971
PNG
(6-((5-chloro-4-(cyclopentylethynyl)-2-methoxypheny...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(Cl)c(cc1OC)C#CC1CCCC1
Show InChI InChI=1S/C24H24ClN5O5S/c1-26-24(31)30(23-10-9-18(15-27-23)36(32,33)29-22-11-12-35-28-22)20-14-19(25)17(13-21(20)34-2)8-7-16-5-3-4-6-16/h9-16H,3-6H2,1-2H3,(H,26,31)(H,28,29)
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n/an/a 68n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444929
PNG
(6-((2-fluoro-5-methoxy-3'-(trifluoromethyl)-4- | U...)
Show SMILES CONC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(F)c(cc1OC)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H19F4N5O6S/c1-37-20-11-17(14-4-3-5-15(10-14)24(26,27)28)18(25)12-19(20)33(23(34)31-38-2)22-7-6-16(13-29-22)40(35,36)32-21-8-9-39-30-21/h3-13H,1-2H3,(H,30,32)(H,31,34)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444916
PNG
(6-((2,4'-dichloro-3',5-dimethoxy-4- | US10668067, ...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ncccn1)c1cc(Cl)c(cc1OC)-c1ccc(Cl)c(OC)c1
Show InChI InChI=1S/C25H22Cl2N6O5S/c1-28-25(34)33(23-8-6-16(14-31-23)39(35,36)32-24-29-9-4-10-30-24)20-13-19(27)17(12-22(20)38-3)15-5-7-18(26)21(11-15)37-2/h4-14H,1-3H3,(H,28,34)(H,29,30,32)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444887
PNG
(6-((2-chloro-5-methoxy-3'-(1-methylethoxy)-4- | US...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(Cl)c(cc1OC)-c1cccc(OC(C)C)c1
Show InChI InChI=1S/C26H26ClN5O6S/c1-16(2)38-18-7-5-6-17(12-18)20-13-23(36-4)22(14-21(20)27)32(26(33)28-3)25-9-8-19(15-29-25)39(34,35)31-24-10-11-37-30-24/h5-16H,1-4H3,(H,28,33)(H,30,31)
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n/an/a 71n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444886
PNG
(6-((2-chloro-3'-(difluoromethoxy)-5-methoxy-4- | U...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(Cl)c(cc1OC)-c1cccc(OC(F)F)c1
Show InChI InChI=1S/C24H20ClF2N5O6S/c1-28-24(33)32(22-7-6-16(13-29-22)39(34,35)31-21-8-9-37-30-21)19-12-18(25)17(11-20(19)36-2)14-4-3-5-15(10-14)38-23(26)27/h3-13,23H,1-2H3,(H,28,33)(H,30,31)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444944
PNG
(6-((2-chloro-4'-fluoro-5-methoxy-3'-(2,2,2-trifluo...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1cccc(F)n1)c1cc(Cl)c(cc1OC)-c1ccc(F)c(OCC(F)(F)F)c1
Show InChI InChI=1S/C27H21ClF5N5O5S/c1-34-26(39)38(25-9-7-16(13-35-25)44(40,41)37-24-5-3-4-23(30)36-24)20-12-18(28)17(11-22(20)42-2)15-6-8-19(29)21(10-15)43-14-27(31,32)33/h3-13H,14H2,1-2H3,(H,34,39)(H,36,37)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444933
PNG
(6-((2-chloro-3',4',5'-trifluoro-5-methoxy-4- | US1...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1cccnn1)c1cc(Cl)c(cc1OC)-c1cc(F)c(F)c(F)c1
Show InChI InChI=1S/C24H18ClF3N6O4S/c1-29-24(35)34(22-6-5-14(12-30-22)39(36,37)33-21-4-3-7-31-32-21)19-11-16(25)15(10-20(19)38-2)13-8-17(26)23(28)18(27)9-13/h3-12H,1-2H3,(H,29,35)(H,32,33)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444946
PNG
(6-((2-chloro-4'-fluoro-5-methoxy-3'-(2,2,2-trifluo...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccnc(C)n1)c1cc(Cl)c(cc1OC)-c1ccc(F)c(OCC(F)(F)F)c1
Show InChI InChI=1S/C27H23ClF4N6O5S/c1-15-34-9-8-24(36-15)37-44(40,41)17-5-7-25(35-13-17)38(26(39)33-2)21-12-19(28)18(11-23(21)42-3)16-4-6-20(29)22(10-16)43-14-27(30,31)32/h4-13H,14H2,1-3H3,(H,33,39)(H,34,36,37)
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n/an/a 76n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444964
PNG
(6-((3',6-dichloro-4-methoxy-4'-methyl-3- | US10668...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(c(Cl)cc1OC)-c1ccc(C)c(Cl)c1
Show InChI InChI=1S/C24H21Cl2N5O5S/c1-14-4-5-15(10-18(14)25)17-11-20(21(35-3)12-19(17)26)31(24(32)27-2)23-7-6-16(13-28-23)37(33,34)30-22-8-9-36-29-22/h4-13H,1-3H3,(H,27,32)(H,29,30)
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n/an/a 76n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444903
PNG
(6-((2-chloro-3',5,5'-trimethoxy-4- | US10668067, E...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(Cl)c(cc1OC)-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C25H24ClN5O7S/c1-27-25(32)31(24-6-5-18(14-28-24)39(33,34)30-23-7-8-38-29-23)21-13-20(26)19(12-22(21)37-4)15-9-16(35-2)11-17(10-15)36-3/h5-14H,1-4H3,(H,27,32)(H,29,30)
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n/an/a 78n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444963
PNG
(6-((3',6-dichloro-4,5'-dimethoxy-3- | US10668067, ...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(c(Cl)cc1OC)-c1cc(Cl)cc(OC)c1
Show InChI InChI=1S/C24H21Cl2N5O6S/c1-27-24(32)31(23-5-4-17(13-28-23)38(33,34)30-22-6-7-37-29-22)20-11-18(19(26)12-21(20)36-3)14-8-15(25)10-16(9-14)35-2/h4-13H,1-3H3,(H,27,32)(H,29,30)
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n/an/a 81n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444913
PNG
(6-((3'-chloro-5'-fluoro-3-methoxy-4- | US10668067,...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1ccc(cc1OC)-c1cc(F)cc(Cl)c1
Show InChI InChI=1S/C23H19ClFN5O5S/c1-26-23(31)30(22-6-4-18(13-27-22)36(32,33)29-21-7-8-35-28-21)19-5-3-14(11-20(19)34-2)15-9-16(24)12-17(25)10-15/h3-13H,1-2H3,(H,26,31)(H,28,29)
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n/an/a 84n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444849
PNG
(6-((2-fluoro-5-methoxy-3'-(2,2,2-trifluoroethoxy)-...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(F)c(cc1OC)-c1cccc(OCC(F)(F)F)c1
Show InChI InChI=1S/C25H21F4N5O6S/c1-30-24(35)34(23-7-6-17(13-31-23)41(36,37)33-22-8-9-40-32-22)20-12-19(26)18(11-21(20)38-2)15-4-3-5-16(10-15)39-14-25(27,28)29/h3-13H,14H2,1-2H3,(H,30,35)(H,32,33)
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n/an/a 85n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444863
PNG
(N-3-isoxazolyl-6-((methylcarbamoyl)(2,3',4',5'-tet...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(F)c(cc1OC)-c1cc(F)c(F)c(F)c1
Show InChI InChI=1S/C23H17F4N5O5S/c1-28-23(33)32(21-4-3-13(11-29-21)38(34,35)31-20-5-6-37-30-20)18-10-15(24)14(9-19(18)36-2)12-7-16(25)22(27)17(26)8-12/h3-11H,1-2H3,(H,28,33)(H,30,31)
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n/an/a 86n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444961
PNG
(6-((6-chloro-4-methoxy-3'-(trifluoromethyl)-3- | U...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(c(Cl)cc1OC)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H19ClF3N5O5S/c1-29-23(34)33(22-7-6-16(13-30-22)39(35,36)32-21-8-9-38-31-21)19-11-17(18(25)12-20(19)37-2)14-4-3-5-15(10-14)24(26,27)28/h3-13H,1-2H3,(H,29,34)(H,31,32)
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n/an/a 90n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444841
PNG
(6-((3'-chloro-2,5'-difluoro-5-methoxy-4- | US10668...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(F)c(cc1OC)-c1cc(F)cc(Cl)c1
Show InChI InChI=1S/C23H18ClF2N5O5S/c1-27-23(32)31(22-4-3-16(12-28-22)37(33,34)30-21-5-6-36-29-21)19-11-18(26)17(10-20(19)35-2)13-7-14(24)9-15(25)8-13/h3-12H,1-2H3,(H,27,32)(H,29,30)
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n/an/a 92n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444911
PNG
(6-((3'-chloro-3,5'-dimethoxy-4- | US10668067, Exam...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1ccc(cc1OC)-c1cc(Cl)cc(OC)c1
Show InChI InChI=1S/C24H22ClN5O6S/c1-26-24(31)30(23-7-5-19(14-27-23)37(32,33)29-22-8-9-36-28-22)20-6-4-15(12-21(20)35-3)16-10-17(25)13-18(11-16)34-2/h4-14H,1-3H3,(H,26,31)(H,28,29)
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n/an/a 101n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444836
PNG
(6-((4'-chloro-2-fluoro-5-methoxy-3'-methyl-4- | US...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1cccnn1)c1cc(F)c(cc1OC)-c1ccc(Cl)c(C)c1
Show InChI InChI=1S/C25H22ClFN6O4S/c1-15-11-16(6-8-19(15)26)18-12-22(37-3)21(13-20(18)27)33(25(34)28-2)24-9-7-17(14-29-24)38(35,36)32-23-5-4-10-30-31-23/h4-14H,1-3H3,(H,28,34)(H,31,32)
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n/an/a 106n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444914
PNG
(6-((2,4'-dichloro-3'-cyano-5-methoxy-4- | US106680...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ncccn1)c1cc(Cl)c(cc1OC)-c1ccc(Cl)c(c1)C#N
Show InChI InChI=1S/C25H19Cl2N7O4S/c1-29-25(35)34(23-7-5-17(14-32-23)39(36,37)33-24-30-8-3-9-31-24)21-12-20(27)18(11-22(21)38-2)15-4-6-19(26)16(10-15)13-28/h3-12,14H,1-2H3,(H,29,35)(H,30,31,33)
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n/an/a 106n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444915
PNG
(6-((2-chloro-3',4'-difluoro-5-methoxy-4- | US10668...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ncccn1)c1cc(Cl)c(cc1OC)-c1ccc(F)c(F)c1
Show InChI InChI=1S/C24H19ClF2N6O4S/c1-28-24(34)33(22-7-5-15(13-31-22)38(35,36)32-23-29-8-3-9-30-23)20-12-17(25)16(11-21(20)37-2)14-4-6-18(26)19(27)10-14/h3-13H,1-2H3,(H,28,34)(H,29,30,32)
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n/an/a 116n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444940
PNG
(6-((1-(2,4'-difluoro-5-methoxy-3'-(trifluoromethyl...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1nocc1C)c1cc(F)c(cc1OC)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C25H20F5N5O5S/c1-13-12-40-33-23(13)34-41(37,38)15-5-7-22(32-11-15)35(24(36)31-2)20-10-19(27)16(9-21(20)39-3)14-4-6-18(26)17(8-14)25(28,29)30/h4-12H,1-3H3,(H,31,36)(H,33,34)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444917
PNG
(6-((2,3'-dichloro-5'-cyano-5-methoxy-4- | US106680...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ncccn1)c1cc(Cl)c(cc1OC)-c1cc(Cl)cc(c1)C#N
Show InChI InChI=1S/C25H19Cl2N7O4S/c1-29-25(35)34(23-5-4-18(14-32-23)39(36,37)33-24-30-6-3-7-31-24)21-12-20(27)19(11-22(21)38-2)16-8-15(13-28)9-17(26)10-16/h3-12,14H,1-2H3,(H,29,35)(H,30,31,33)
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n/an/a 123n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444854
PNG
(6-((2,3'-difluoro-5-methoxy-4'-methyl-4- | US10668...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(F)c(cc1OC)-c1ccc(C)c(F)c1
Show InChI InChI=1S/C24H21F2N5O5S/c1-14-4-5-15(10-18(14)25)17-11-21(35-3)20(12-19(17)26)31(24(32)27-2)23-7-6-16(13-28-23)37(33,34)30-22-8-9-36-29-22/h4-13H,1-3H3,(H,27,32)(H,29,30)
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n/an/a 124n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444883
PNG
(6-((2-chloro-4'-fluoro-5-methoxy-4- | US10668067, ...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(Cl)c(cc1OC)-c1ccc(F)cc1
Show InChI InChI=1S/C23H19ClFN5O5S/c1-26-23(31)30(22-8-7-16(13-27-22)36(32,33)29-21-9-10-35-28-21)19-12-18(24)17(11-20(19)34-2)14-3-5-15(25)6-4-14/h3-13H,1-2H3,(H,26,31)(H,28,29)
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n/an/a 125n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444882
PNG
(6-((5-chloro-2-methoxy-4-(2-(trifluoromethyl)-4- |...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(Cl)c(cc1OC)-c1ccnc(c1)C(F)(F)F
Show InChI InChI=1S/C23H18ClF3N6O5S/c1-28-22(34)33(21-4-3-14(12-30-21)39(35,36)32-20-6-8-38-31-20)17-11-16(24)15(10-18(17)37-2)13-5-7-29-19(9-13)23(25,26)27/h3-12H,1-2H3,(H,28,34)(H,31,32)
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n/an/a 131n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444920
PNG
(6-((2-fluoro-5-methoxy-3'-(trifluoromethyl)-4- | U...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ncccn1)c1cc(F)c(cc1OC)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H20F4N6O4S/c1-30-24(36)35(22-8-7-17(14-33-22)40(37,38)34-23-31-9-4-10-32-23)20-13-19(26)18(12-21(20)39-2)15-5-3-6-16(11-15)25(27,28)29/h3-14H,1-2H3,(H,30,36)(H,31,32,34)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444857
PNG
(6-((2,3'-difluoro-5-methoxy-5'-methyl-4- | US10668...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(F)c(cc1OC)-c1cc(C)cc(F)c1
Show InChI InChI=1S/C24H21F2N5O5S/c1-14-8-15(10-16(25)9-14)18-11-21(35-3)20(12-19(18)26)31(24(32)27-2)23-5-4-17(13-28-23)37(33,34)30-22-6-7-36-29-22/h4-13H,1-3H3,(H,27,32)(H,29,30)
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n/an/a 146n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444862
PNG
(6-((2,4'-difluoro-3',5,5'-trimethoxy-4- | US106680...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(F)c(cc1OC)-c1cc(OC)c(F)c(OC)c1
Show InChI InChI=1S/C25H23F2N5O7S/c1-28-25(33)32(23-6-5-15(13-29-23)40(34,35)31-22-7-8-39-30-22)18-12-17(26)16(11-19(18)36-2)14-9-20(37-3)24(27)21(10-14)38-4/h5-13H,1-4H3,(H,28,33)(H,30,31)
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n/an/a 151n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444880
PNG
(6-((5-chloro-4-(5-chloro-2-methoxy-3-pyridinyl)-2-...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(Cl)c(cc1OC)-c1cc(Cl)cnc1OC
Show InChI InChI=1S/C23H20Cl2N6O6S/c1-26-23(32)31(21-5-4-14(12-27-21)38(33,34)30-20-6-7-37-29-20)18-10-17(25)15(9-19(18)35-2)16-8-13(24)11-28-22(16)36-3/h4-12H,1-3H3,(H,26,32)(H,29,30)
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n/an/a 166n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444918
PNG
(6-((2-chloro-3',5,5'-trimethoxy-4- | US10668067, E...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ncccn1)c1cc(Cl)c(cc1OC)-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C26H25ClN6O6S/c1-28-26(34)33(24-7-6-19(15-31-24)40(35,36)32-25-29-8-5-9-30-25)22-14-21(27)20(13-23(22)39-4)16-10-17(37-2)12-18(11-16)38-3/h5-15H,1-4H3,(H,28,34)(H,29,30,32)
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n/an/a 166n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444970
PNG
(Methyl (2-chloro-5-methoxy-3′-(trifluorometh...)
Show SMILES COC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(Cl)c(cc1OC)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H18ClF3N4O6S/c1-36-20-11-17(14-4-3-5-15(10-14)24(26,27)28)18(25)12-19(20)32(23(33)37-2)22-7-6-16(13-29-22)39(34,35)31-21-8-9-38-30-21/h3-13H,1-2H3,(H,30,31)
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n/an/a 167n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444959
PNG
(6-((3'-chloro-5'-fluoro-4-methoxy-3- | US10668067,...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(ccc1OC)-c1cc(F)cc(Cl)c1
Show InChI InChI=1S/C23H19ClFN5O5S/c1-26-23(31)30(22-6-4-18(13-27-22)36(32,33)29-21-7-8-35-28-21)19-11-14(3-5-20(19)34-2)15-9-16(24)12-17(25)10-15/h3-13H,1-2H3,(H,26,31)(H,28,29)
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n/an/a 173n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444874
PNG
(6-((4'-chloro-2-fluoro-3',5-dimethoxy-4- | US10668...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(F)c(cc1OC)-c1ccc(Cl)c(OC)c1
Show InChI InChI=1S/C24H21ClFN5O6S/c1-27-24(32)31(23-7-5-15(13-28-23)38(33,34)30-22-8-9-37-29-22)19-12-18(26)16(11-21(19)36-3)14-4-6-17(25)20(10-14)35-2/h4-13H,1-3H3,(H,27,32)(H,29,30)
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n/an/a 185n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444957
PNG
(N-3-isoxazolyl-6-((4-methoxy-3'-(trifluoromethyl)-...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(ccc1OC)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H20F3N5O5S/c1-28-23(33)32(22-9-7-18(14-29-22)38(34,35)31-21-10-11-37-30-21)19-13-16(6-8-20(19)36-2)15-4-3-5-17(12-15)24(25,26)27/h3-14H,1-2H3,(H,28,33)(H,30,31)
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n/an/a 187n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444861
PNG
(N-3-isoxazolyl-6-((methylcarbamoyl)(2,3',4'-triflu...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(F)c(cc1OC)-c1ccc(F)c(F)c1
Show InChI InChI=1S/C23H18F3N5O5S/c1-27-23(32)31(22-6-4-14(12-28-22)37(33,34)30-21-7-8-36-29-21)19-11-17(25)15(10-20(19)35-2)13-3-5-16(24)18(26)9-13/h3-12H,1-2H3,(H,27,32)(H,29,30)
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n/an/a 199n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444845
PNG
(6-((2-fluoro-3',5-dimethoxy-4-biphenylyl)(methylca...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(F)c(cc1OC)-c1cccc(OC)c1
Show InChI InChI=1S/C24H22FN5O6S/c1-26-24(31)30(23-8-7-17(14-27-23)37(32,33)29-22-9-10-36-28-22)20-13-19(25)18(12-21(20)35-3)15-5-4-6-16(11-15)34-2/h4-14H,1-3H3,(H,26,31)(H,28,29)
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n/an/a 206n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444974
PNG
(4-(1-(2,4′-difluoro-5-methoxy-3′-(trif...)
Show SMILES CNC(=O)N(c1ccc(cc1)S(=O)(=O)N(Cc1ccc(OC)cc1)c1ccon1)c1cc(F)c(Br)cc1OC
Show InChI InChI=1S/C26H24BrFN4O6S/c1-29-26(33)32(23-15-22(28)21(27)14-24(23)37-3)18-6-10-20(11-7-18)39(34,35)31(25-12-13-38-30-25)16-17-4-8-19(36-2)9-5-17/h4-15H,16H2,1-3H3,(H,29,33)
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n/an/a 210n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444925
PNG
(6-((methylcarbamoyl)(2,3',4',5'-tetrafluoro-5-meth...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ncccn1)c1cc(F)c(cc1OC)-c1cc(F)c(F)c(F)c1
Show InChI InChI=1S/C24H18F4N6O4S/c1-29-24(35)34(21-5-4-14(12-32-21)39(36,37)33-23-30-6-3-7-31-23)19-11-16(25)15(10-20(19)38-2)13-8-17(26)22(28)18(27)9-13/h3-12H,1-2H3,(H,29,35)(H,30,31,33)
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n/an/a 220n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444910
PNG
(6-((4'-fluoro-3-methoxy-3'-methyl-4- | US10668067,...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1ccc(cc1OC)-c1ccc(F)c(C)c1
Show InChI InChI=1S/C24H22FN5O5S/c1-15-12-16(4-7-19(15)25)17-5-8-20(21(13-17)34-3)30(24(31)26-2)23-9-6-18(14-27-23)36(32,33)29-22-10-11-35-28-22/h4-14H,1-3H3,(H,26,31)(H,28,29)
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n/an/a 398n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444973
PNG
(4-(1-(4′-chloro-3-methoxy-3′-methyl-[1...)
Show SMILES COc1cc(ccc1Nc1ccc(cc1)S(=O)(=O)N(Cc1ccc(C=O)cc1)c1ccon1)-c1ccc(Cl)c(C)c1
Show InChI InChI=1S/C31H26ClN3O5S/c1-21-17-24(7-13-28(21)32)25-8-14-29(30(18-25)39-2)33-26-9-11-27(12-10-26)41(37,38)35(31-15-16-40-34-31)19-22-3-5-23(20-36)6-4-22/h3-18,20,33H,19H2,1-2H3
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n/an/a 400n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444960
PNG
(6-((3'-chloro-4-methoxy-4'-methyl-3- | US10668067,...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(ccc1OC)-c1ccc(C)c(Cl)c1
Show InChI InChI=1S/C24H22ClN5O5S/c1-15-4-5-16(12-19(15)25)17-6-8-21(34-3)20(13-17)30(24(31)26-2)23-9-7-18(14-27-23)36(32,33)29-22-10-11-35-28-22/h4-14H,1-3H3,(H,26,31)(H,28,29)
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n/an/a 442n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444956
PNG
(6-((3'-chloro-4,5'-dimethoxy-3- | US10668067, Exam...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(ccc1OC)-c1cc(Cl)cc(OC)c1
Show InChI InChI=1S/C24H22ClN5O6S/c1-26-24(31)30(23-7-5-19(14-27-23)37(32,33)29-22-8-9-36-28-22)20-12-15(4-6-21(20)35-3)16-10-17(25)13-18(11-16)34-2/h4-14H,1-3H3,(H,26,31)(H,28,29)
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n/an/a 461n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444941
PNG
(6-((1-(2,4'-difluoro-5-methoxy-3'-(2,2,2-trifluoro...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1nocc1C)c1cc(F)c(cc1OC)-c1ccc(F)c(OCC(F)(F)F)c1
Show InChI InChI=1S/C26H22F5N5O6S/c1-14-12-42-34-24(14)35-43(38,39)16-5-7-23(33-11-16)36(25(37)32-2)20-10-19(28)17(9-22(20)40-3)15-4-6-18(27)21(8-15)41-13-26(29,30)31/h4-12H,13H2,1-3H3,(H,32,37)(H,34,35)
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n/an/a 621n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444972
PNG
(6-((5-fluoro-2-methoxy-4-(3,3,3-trifluoropropyl)ph...)
Show SMILES COc1ccc(CN(C)C(=O)N(c2ccc(SCc3ccccc3)cn2)c2cc(F)c(CCC(F)(F)F)cc2OC)cc1
Show InChI InChI=1S/C32H31F4N3O3S/c1-38(20-22-9-11-25(41-2)12-10-22)31(40)39(28-18-27(33)24(17-29(28)42-3)15-16-32(34,35)36)30-14-13-26(19-37-30)43-21-23-7-5-4-6-8-23/h4-14,17-19H,15-16,20-21H2,1-3H3
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n/an/a 849n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444962
PNG
(6-((6-chloro-3'-fluoro-4-methoxy-3- | US10668067, ...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(c(Cl)cc1OC)-c1cccc(F)c1
Show InChI InChI=1S/C23H19ClFN5O5S/c1-26-23(31)30(22-7-6-16(13-27-22)36(32,33)29-21-8-9-35-28-21)19-11-17(18(24)12-20(19)34-2)14-4-3-5-15(25)10-14/h3-13H,1-2H3,(H,26,31)(H,28,29)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444958
PNG
(6-((3'-fluoro-4-methoxy-3-biphenylyl)(methylcarbam...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(ccc1OC)-c1cccc(F)c1
Show InChI InChI=1S/C23H20FN5O5S/c1-25-23(30)29(19-13-16(6-8-20(19)33-2)15-4-3-5-17(24)12-15)22-9-7-18(14-26-22)35(31,32)28-21-10-11-34-27-21/h3-14H,1-2H3,(H,25,30)(H,27,28)
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n/an/a 2.37E+3n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM444898
PNG
(6-((5-chloro-4-cyclopropyl-2- | US10668067, Exampl...)
Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(Cl)c(cc1OC)C1CC1
Show InChI InChI=1S/C20H20ClN5O5S/c1-22-20(27)26(16-10-15(21)14(12-3-4-12)9-17(16)30-2)19-6-5-13(11-23-19)32(28,29)25-18-7-8-31-24-18/h5-12H,3-4H2,1-2H3,(H,22,27)(H,24,25)
PDB

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UniChem
US Patent
n/an/a 3.02E+3n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US10668067 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%