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Patent code US10668071

Compile Data Set for Download or QSAR
Found 105 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290292
PNG
(2-Oxo-4-(piperidin-4-yl)-1,2-dihydropyrimido[1,2-b...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3cccc(C#N)c3c2[nH]1
Show InChI InChI=1S/C16H15N5O/c17-9-11-2-1-3-12-15(11)16-19-14(22)8-13(21(16)20-12)10-4-6-18-7-5-10/h1-3,8,10,18H,4-7H2,(H,19,22)
PDB

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US Patent
n/an/a 10n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290336
PNG
(10-Chloro-8-methyl-4-(piperidin-4-yl)pyrimido[1,2-...)
Show SMILES Cc1cc(Cl)c2c(c1)nn1c(cc(=O)[nH]c21)C1CCNCC1
Show InChI InChI=1S/C16H17ClN4O/c1-9-6-11(17)15-12(7-9)20-21-13(8-14(22)19-16(15)21)10-2-4-18-5-3-10/h6-8,10,18H,2-5H2,1H3,(H,19,22)
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n/an/a 11n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290334
PNG
(9-Fluoro-10-phenyl-4-(piperidin-4-yl)pyrimido[1,2-...)
Show SMILES Fc1ccc2nn3c(cc(=O)[nH]c3c2c1-c1ccccc1)C1CCNCC1
Show InChI InChI=1S/C21H19FN4O/c22-15-6-7-16-20(19(15)14-4-2-1-3-5-14)21-24-18(27)12-17(26(21)25-16)13-8-10-23-11-9-13/h1-7,12-13,23H,8-11H2,(H,24,27)
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n/an/a 11n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290309
PNG
((−)-trans-10-Ethoxy-4-(2-methylpiperidin-4-y...)
Show SMILES CCOc1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNC(C)C1
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n/an/a 13n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290314
PNG
(10-(2-Fluorophenyl)-4-(piperidin-4-yl)pyrimido[1,2...)
Show SMILES Fc1ccccc1-c1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C21H19FN4O/c22-16-6-2-1-4-14(16)15-5-3-7-17-20(15)21-24-19(27)12-18(26(21)25-17)13-8-10-23-11-9-13/h1-7,12-13,23H,8-11H2,(H,24,27)
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n/an/a 13n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290324
PNG
(4-(Piperidin-4-yl)-10-[2-(trifluoromethyl)phenyl]p...)
Show SMILES FC(F)(F)c1ccccc1-c1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C22H19F3N4O/c23-22(24,25)16-6-2-1-4-14(16)15-5-3-7-17-20(15)21-27-19(30)12-18(29(21)28-17)13-8-10-26-11-9-13/h1-7,12-13,26H,8-11H2,(H,27,30)
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n/an/a 13n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290286
PNG
(7-Bromo-4-(piperidin-4-yl)pyrido[4′,3′...)
Show SMILES Brc1cncc2c1nn1c(cc(=O)[nH]c21)C1CCNCC1
Show InChI InChI=1S/C14H14BrN5O/c15-10-7-17-6-9-13(10)19-20-11(5-12(21)18-14(9)20)8-1-3-16-4-2-8/h5-8,16H,1-4H2,(H,18,21)
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n/an/a 13n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290320
PNG
(10-Cyclopentyl-4-(piperidin-4-yl)pyrimido[1,2-b]in...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3cccc(C4CCCC4)c3c2[nH]1
Show InChI InChI=1S/C20H24N4O/c25-18-12-17(14-8-10-21-11-9-14)24-20(22-18)19-15(13-4-1-2-5-13)6-3-7-16(19)23-24/h3,6-7,12-14,21H,1-2,4-5,8-11H2,(H,22,25)
PDB

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n/an/a 13n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290329
PNG
(10-sec-Butyl-4-(piperidin-4-yl)pyrimido[1,2-b]inda...)
Show SMILES CCC(C)c1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
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n/an/a 14n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290312
PNG
(4-(Piperidin-4-yl)-10-[4-(trifluoromethyl)phenyl]p...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C22H19F3N4O/c23-22(24,25)15-6-4-13(5-7-15)16-2-1-3-17-20(16)21-27-19(30)12-18(29(21)28-17)14-8-10-26-11-9-14/h1-7,12,14,26H,8-11H2,(H,27,30)
PDB

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n/an/a 14n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290269
PNG
(10-Bromo-4-(piperidin-4-yl)pyrimido[1,2-b]indazol-...)
Show SMILES Brc1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C15H15BrN4O/c16-10-2-1-3-11-14(10)15-18-13(21)8-12(20(15)19-11)9-4-6-17-7-5-9/h1-3,8-9,17H,4-7H2,(H,18,21)
PDB

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n/an/a 14n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290313
PNG
(10-Phenyl-4-(piperidin-4-yl)pyrimido[1,2-b]indazol...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3cccc(-c4ccccc4)c3c2[nH]1
Show InChI InChI=1S/C21H20N4O/c26-19-13-18(15-9-11-22-12-10-15)25-21(23-19)20-16(7-4-8-17(20)24-25)14-5-2-1-3-6-14/h1-8,13,15,22H,9-12H2,(H,23,26)
PDB

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n/an/a 14n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290307
PNG
((−)-trans-10-Bromo-4-(2-methylpiperidin-4-yl...)
Show SMILES CC1CC(CCN1)c1cc(=O)[nH]c2c3c(Br)cccc3nn12
PDB

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n/an/a 14n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290331
PNG
(10-Bromo-9-methyl-4-(piperidin-4-yl)pyrimido[1,2-b...)
Show SMILES Cc1ccc2nn3c(cc(=O)[nH]c3c2c1Br)C1CCNCC1
Show InChI InChI=1S/C16H17BrN4O/c1-9-2-3-11-14(15(9)17)16-19-13(22)8-12(21(16)20-11)10-4-6-18-7-5-10/h2-3,8,10,18H,4-7H2,1H3,(H,19,22)
PDB

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n/an/a 15n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290343
PNG
(10-(1-Methyl-1H-pyrazol-5-yl)-4-(piperidin-4-yl)py...)
Show SMILES Cn1nccc1-c1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C19H20N6O/c1-24-15(7-10-21-24)13-3-2-4-14-18(13)19-22-17(26)11-16(25(19)23-14)12-5-8-20-9-6-12/h2-4,7,10-12,20H,5-6,8-9H2,1H3,(H,22,26)
PDB

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n/an/a 15n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290308
PNG
((−)-trans-4-(2-Methylpiperidin-4-yl)-10-phen...)
Show SMILES CC1CC(CCN1)c1cc(=O)[nH]c2c3c(ccnc3nn12)-c1ccccc1
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n/an/a 15n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290311
PNG
(10-(4-Methoxyphenyl)-4-(piperidin-4-yl)pyrimido[1,...)
Show SMILES COc1ccc(cc1)-c1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C22H22N4O2/c1-28-16-7-5-14(6-8-16)17-3-2-4-18-21(17)22-24-20(27)13-19(26(22)25-18)15-9-11-23-12-10-15/h2-8,13,15,23H,9-12H2,1H3,(H,24,27)
PDB

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n/an/a 15n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290333
PNG
(10-Isopropoxy-4-(piperidin-4-yl)pyrimido[1,2-b]ind...)
Show SMILES CC(C)Oc1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C18H22N4O2/c1-11(2)24-15-5-3-4-13-17(15)18-20-16(23)10-14(22(18)21-13)12-6-8-19-9-7-12/h3-5,10-12,19H,6-9H2,1-2H3,(H,20,23)
PDB

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n/an/a 15n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290335
PNG
(10-(2,6-Difluorophenyl)-4-(piperidin-4-yl)pyrimido...)
Show SMILES Fc1cccc(F)c1-c1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C21H18F2N4O/c22-14-4-2-5-15(23)19(14)13-3-1-6-16-20(13)21-25-18(28)11-17(27(21)26-16)12-7-9-24-10-8-12/h1-6,11-12,24H,7-10H2,(H,25,28)
PDB

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n/an/a 15n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290315
PNG
(4-(Piperidin-4-yl)-10-(pyridin-3-yl)pyrimido[1,2-b...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3cccc(-c4cccnc4)c3c2[nH]1
Show InChI InChI=1S/C20H19N5O/c26-18-11-17(13-6-9-21-10-7-13)25-20(23-18)19-15(4-1-5-16(19)24-25)14-3-2-8-22-12-14/h1-5,8,11-13,21H,6-7,9-10H2,(H,23,26)
PDB

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n/an/a 15n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290262
PNG
(10-Chloro-4-(piperidin-4-yl)pyrimido[1,2-b]indazol...)
Show SMILES Clc1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C15H15ClN4O/c16-10-2-1-3-11-14(10)15-18-13(21)8-12(20(15)19-11)9-4-6-17-7-5-9/h1-3,8-9,17H,4-7H2,(H,18,21)
PDB

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n/an/a 15n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290328
PNG
(10-Bromo-7-fluoro-4-(piperidin-4-yl)pyrimido[1,2-b...)
Show SMILES Fc1ccc(Br)c2c1nn1c(cc(=O)[nH]c21)C1CCNCC1
Show InChI InChI=1S/C15H14BrFN4O/c16-9-1-2-10(17)14-13(9)15-19-12(22)7-11(21(15)20-14)8-3-5-18-6-4-8/h1-2,7-8,18H,3-6H2,(H,19,22)
PDB

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n/an/a 15n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290338
PNG
(10-Bromo-8-fluoro-4-(piperidin-4-yl)pyrimido[1,2-b...)
Show SMILES Fc1cc(Br)c2c(c1)nn1c(cc(=O)[nH]c21)C1CCNCC1
Show InChI InChI=1S/C15H14BrFN4O/c16-10-5-9(17)6-11-14(10)15-19-13(22)7-12(21(15)20-11)8-1-3-18-4-2-8/h5-8,18H,1-4H2,(H,19,22)
PDB

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n/an/a 16n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290332
PNG
(10-Bromo-7-methyl-4-(piperidin-4-yl)pyrimido[1,2-b...)
Show SMILES Cc1ccc(Br)c2c1nn1c(cc(=O)[nH]c21)C1CCNCC1
Show InChI InChI=1S/C16H17BrN4O/c1-9-2-3-11(17)14-15(9)20-21-12(8-13(22)19-16(14)21)10-4-6-18-7-5-10/h2-3,8,10,18H,4-7H2,1H3,(H,19,22)
PDB

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n/an/a 16n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290316
PNG
(4-(Piperidin-4-yl)-10-(pyridin-4-yl)pyrimido[1,2-b...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3cccc(-c4ccncc4)c3c2[nH]1
Show InChI InChI=1S/C20H19N5O/c26-18-12-17(14-6-10-22-11-7-14)25-20(23-18)19-15(2-1-3-16(19)24-25)13-4-8-21-9-5-13/h1-5,8-9,12,14,22H,6-7,10-11H2,(H,23,26)
PDB

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n/an/a 16n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290303
PNG
(10-Phenyl-4-(piperidin-4-yl)pyrido[2′,3̸...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3nccc(-c4ccccc4)c3c2[nH]1
Show InChI InChI=1S/C20H19N5O/c26-17-12-16(14-6-9-21-10-7-14)25-20(23-17)18-15(8-11-22-19(18)24-25)13-4-2-1-3-5-13/h1-5,8,11-12,14,21H,6-7,9-10H2,(H,23,26)
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n/an/a 17n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290337
PNG
(4-(Piperidin-4-yl)-10-[2-(trifluoromethoxy)phenyl]...)
Show SMILES FC(F)(F)Oc1ccccc1-c1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C22H19F3N4O2/c23-22(24,25)31-18-7-2-1-4-14(18)15-5-3-6-16-20(15)21-27-19(30)12-17(29(21)28-16)13-8-10-26-11-9-13/h1-7,12-13,26H,8-11H2,(H,27,30)
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n/an/a 18n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290314
PNG
(10-(2-Fluorophenyl)-4-(piperidin-4-yl)pyrimido[1,2...)
Show SMILES Fc1ccccc1-c1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C21H19FN4O/c22-16-6-2-1-4-14(16)15-5-3-7-17-20(15)21-24-19(27)12-18(26(21)25-17)13-8-10-23-11-9-13/h1-7,12-13,23H,8-11H2,(H,24,27)
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n/an/a 18n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290319
PNG
(10-Isopropyl-4-(piperidin-4-yl)pyrimido[1,2-b]inda...)
Show SMILES CC(C)c1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C18H22N4O/c1-11(2)13-4-3-5-14-17(13)18-20-16(23)10-15(22(18)21-14)12-6-8-19-9-7-12/h3-5,10-12,19H,6-9H2,1-2H3,(H,20,23)
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n/an/a 18n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290293
PNG
(10-Methyl-4-(piperidin-4-yl)pyrimido[1,2-b]indazol...)
Show SMILES Cc1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C16H18N4O/c1-10-3-2-4-12-15(10)16-18-14(21)9-13(20(16)19-12)11-5-7-17-8-6-11/h2-4,9,11,17H,5-8H2,1H3,(H,18,21)
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n/an/a 18n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290342
PNG
(10-(2-Methylphenyl)-4-(piperidin-4-yl)pyrimido[1,2...)
Show SMILES Cc1ccccc1-c1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C22H22N4O/c1-14-5-2-3-6-16(14)17-7-4-8-18-21(17)22-24-20(27)13-19(26(22)25-18)15-9-11-23-12-10-15/h2-8,13,15,23H,9-12H2,1H3,(H,24,27)
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n/an/a 18n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290321
PNG
(10-(2-Chlorophenyl)-4-(piperidin-4-yl)pyrimido[1,2...)
Show SMILES Clc1ccccc1-c1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C21H19ClN4O/c22-16-6-2-1-4-14(16)15-5-3-7-17-20(15)21-24-19(27)12-18(26(21)25-17)13-8-10-23-11-9-13/h1-7,12-13,23H,8-11H2,(H,24,27)
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n/an/a 19n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290326
PNG
(10-Chloro-9-methyl-4-(piperidin-4-yl)pyrimido[1,2-...)
Show SMILES Cc1ccc2nn3c(cc(=O)[nH]c3c2c1Cl)C1CCNCC1
Show InChI InChI=1S/C16H17ClN4O/c1-9-2-3-11-14(15(9)17)16-19-13(22)8-12(21(16)20-11)10-4-6-18-7-5-10/h2-3,8,10,18H,4-7H2,1H3,(H,19,22)
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n/an/a 20n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290339
PNG
(4-(Piperidin-4-yl)-10-(pyridin-2-yl)pyrimido[1,2-b...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3cccc(-c4ccccn4)c3c2[nH]1
Show InChI InChI=1S/C20H19N5O/c26-18-12-17(13-7-10-21-11-8-13)25-20(23-18)19-14(4-3-6-16(19)24-25)15-5-1-2-9-22-15/h1-6,9,12-13,21H,7-8,10-11H2,(H,23,26)
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n/an/a 20n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290284
PNG
(3-Fluoro-7-(piperidin-4-yl)pyrido[3′,2′...)
Show SMILES Fc1cnc2c(c1)nn1c(cc(=O)[nH]c21)C1CCNCC1
Show InChI InChI=1S/C14H14FN5O/c15-9-5-10-13(17-7-9)14-18-12(21)6-11(20(14)19-10)8-1-3-16-4-2-8/h5-8,16H,1-4H2,(H,18,21)
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n/an/a 21n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290292
PNG
(2-Oxo-4-(piperidin-4-yl)-1,2-dihydropyrimido[1,2-b...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3cccc(C#N)c3c2[nH]1
Show InChI InChI=1S/C16H15N5O/c17-9-11-2-1-3-12-15(11)16-19-14(22)8-13(21(16)20-12)10-4-6-18-7-5-10/h1-3,8,10,18H,4-7H2,(H,19,22)
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n/an/a 21n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290276
PNG
(3,4-Dimethyl-8-(piperidin-4-yl)pyrimido[1′,2...)
Show SMILES Cc1nnc2nn3c(cc(=O)[nH]c3c2c1C)C1CCNCC1
Show InChI InChI=1S/C15H18N6O/c1-8-9(2)18-19-14-13(8)15-17-12(22)7-11(21(15)20-14)10-3-5-16-6-4-10/h7,10,16H,3-6H2,1-2H3,(H,17,22)
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n/an/a 22n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290279
PNG
(10-Iodo-4-(piperidin-4-yl)pyrimido[1,2-b]indazol-2...)
Show SMILES Ic1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C15H15IN4O/c16-10-2-1-3-11-14(10)15-18-13(21)8-12(20(15)19-11)9-4-6-17-7-5-9/h1-3,8-9,17H,4-7H2,(H,18,21)
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n/an/a 22n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290330
PNG
(10-Isobutyl-4-(piperidin-4-yl)pyrimido[1,2-b]indaz...)
Show SMILES CC(C)Cc1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C19H24N4O/c1-12(2)10-14-4-3-5-15-18(14)19-21-17(24)11-16(23(19)22-15)13-6-8-20-9-7-13/h3-5,11-13,20H,6-10H2,1-2H3,(H,21,24)
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n/an/a 23n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290298
PNG
(10-Chloro-4-(piperidin-4-yl)-8-(trifluoromethyl)py...)
Show SMILES FC(F)(F)c1cc(Cl)c2c(c1)nn1c(cc(=O)[nH]c21)C1CCNCC1
Show InChI InChI=1S/C16H14ClF3N4O/c17-10-5-9(16(18,19)20)6-11-14(10)15-22-13(25)7-12(24(15)23-11)8-1-3-21-4-2-8/h5-8,21H,1-4H2,(H,22,25)
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n/an/a 23n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290341
PNG
(4-(Piperidin-4-yl)-10-(3-thienyl)pyrimido[1,2-b]in...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3cccc(-c4ccsc4)c3c2[nH]1
Show InChI InChI=1S/C19H18N4OS/c24-17-10-16(12-4-7-20-8-5-12)23-19(21-17)18-14(13-6-9-25-11-13)2-1-3-15(18)22-23/h1-3,6,9-12,20H,4-5,7-8H2,(H,21,24)
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n/an/a 23n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290347
PNG
(10-Chloro-9-fluoro-4-(piperidin-4-yl)pyrimido[1,2-...)
Show SMILES Fc1ccc2nn3c(cc(=O)[nH]c3c2c1Cl)C1CCNCC1
Show InChI InChI=1S/C15H14ClFN4O/c16-14-9(17)1-2-10-13(14)15-19-12(22)7-11(21(15)20-10)8-3-5-18-6-4-8/h1-2,7-8,18H,3-6H2,(H,19,22)
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n/an/a 24n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290304
PNG
(10-methyl-4-(piperidin-4-yl)pyrido[2′,3̸...)
Show SMILES Cc1ccnc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C15H17N5O/c1-9-2-7-17-14-13(9)15-18-12(21)8-11(20(15)19-14)10-3-5-16-6-4-10/h2,7-8,10,16H,3-6H2,1H3,(H,18,21)
PDB

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n/an/a 24n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290296
PNG
(8-Chloro-4-(piperidin-4-yl)pyrimido[1,2-b]indazol-...)
Show SMILES Clc1ccc2c(c1)nn1c(cc(=O)[nH]c21)C1CCNCC1
Show InChI InChI=1S/C15H15ClN4O/c16-10-1-2-11-12(7-10)19-20-13(8-14(21)18-15(11)20)9-3-5-17-6-4-9/h1-2,7-9,17H,3-6H2,(H,18,21)
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n/an/a 24n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290318
PNG
(10-Cyclopropyl-4-(piperidin-4-yl)pyrimido[1,2-b]in...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3cccc(C4CC4)c3c2[nH]1
Show InChI InChI=1S/C18H20N4O/c23-16-10-15(12-6-8-19-9-7-12)22-18(20-16)17-13(11-4-5-11)2-1-3-14(17)21-22/h1-3,10-12,19H,4-9H2,(H,20,23)
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n/an/a 24n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290322
PNG
(10-(2-Methoxyphenyl)-4-(piperidin-4-yl)pyrimido[1,...)
Show SMILES COc1ccccc1-c1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C22H22N4O2/c1-28-19-8-3-2-5-15(19)16-6-4-7-17-21(16)22-24-20(27)13-18(26(22)25-17)14-9-11-23-12-10-14/h2-8,13-14,23H,9-12H2,1H3,(H,24,27)
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n/an/a 25n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290325
PNG
((−)-trans-10-Chloro-4-(2-methylpiperidin-4-y...)
Show SMILES CC1CC(CCN1)c1cc(=O)[nH]c2c3c(Cl)cccc3nn12
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n/an/a 25n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290344
PNG
(10-(1-Methyl-1H-pyrazol-4-yl)-4-(piperidin-4-yl)py...)
Show SMILES Cn1cc(cn1)-c1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C19H20N6O/c1-24-11-13(10-21-24)14-3-2-4-15-18(14)19-22-17(26)9-16(25(19)23-15)12-5-7-20-8-6-12/h2-4,9-12,20H,5-8H2,1H3,(H,22,26)
PDB

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n/an/a 25n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290353
PNG
(4-(Piperidin-4-yl)-10-(1H-pyrazol-1-yl)pyrimido[1,...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3cccc(-n4cccn4)c3c2[nH]1
Show InChI InChI=1S/C18H18N6O/c25-16-11-15(12-5-8-19-9-6-12)24-18(21-16)17-13(22-24)3-1-4-14(17)23-10-2-7-20-23/h1-4,7,10-12,19H,5-6,8-9H2,(H,21,25)
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n/an/a 26n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290270
PNG
(4-(Piperidin-4-yl)-8-(trifluoromethyl)pyrimido[1,2...)
Show SMILES FC(F)(F)c1ccc2c(c1)nn1c(cc(=O)[nH]c21)C1CCNCC1
Show InChI InChI=1S/C16H15F3N4O/c17-16(18,19)10-1-2-11-12(7-10)22-23-13(8-14(24)21-15(11)23)9-3-5-20-6-4-9/h1-2,7-9,20H,3-6H2,(H,21,24)
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n/an/a 26n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290345
PNG
(4-(Piperidin-4-yl)-10-(2-thienyl)pyrimido[1,2-b]in...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3cccc(-c4cccs4)c3c2[nH]1
Show InChI InChI=1S/C19H18N4OS/c24-17-11-15(12-6-8-20-9-7-12)23-19(21-17)18-13(16-5-2-10-25-16)3-1-4-14(18)22-23/h1-5,10-12,20H,6-9H2,(H,21,24)
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n/an/a 26n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290278
PNG
(9-Bromo-4-(piperidin-4-yl)pyrimido[1,2-b]indazol-2...)
Show SMILES Brc1ccc2nn3c(cc(=O)[nH]c3c2c1)C1CCNCC1
Show InChI InChI=1S/C15H15BrN4O/c16-10-1-2-12-11(7-10)15-18-14(21)8-13(20(15)19-12)9-3-5-17-6-4-9/h1-2,7-9,17H,3-6H2,(H,18,21)
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n/an/a 26n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290281
PNG
(7-Chloro-4-(piperidin-4-yl)pyrimido[1,2-b]indazol-...)
Show SMILES Clc1cccc2c1nn1c(cc(=O)[nH]c21)C1CCNCC1
Show InChI InChI=1S/C15H15ClN4O/c16-11-3-1-2-10-14(11)19-20-12(8-13(21)18-15(10)20)9-4-6-17-7-5-9/h1-3,8-9,17H,4-7H2,(H,18,21)
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n/an/a 26n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290348
PNG
(4-(Piperidin-4-yl)-10-(1H-1,2,4-triazol-1-yl)pyrim...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3cccc(-n4cncn4)c3c2[nH]1
Show InChI InChI=1S/C17H17N7O/c25-15-8-14(11-4-6-18-7-5-11)24-17(21-15)16-12(22-24)2-1-3-13(16)23-10-19-9-20-23/h1-3,8-11,18H,4-7H2,(H,21,25)
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n/an/a 27n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290349
PNG
(9-Fluoro-10-(2-fluorophenyl)-4-(piperidin-4-yl)pyr...)
Show SMILES Fc1ccccc1-c1c(F)ccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C21H18F2N4O/c22-14-4-2-1-3-13(14)19-15(23)5-6-16-20(19)21-25-18(28)11-17(27(21)26-16)12-7-9-24-10-8-12/h1-6,11-12,24H,7-10H2,(H,25,28)
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n/an/a 27n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290355
PNG
(4-(Piperidin-4-yl)-10-(2H-1,2,3-triazol-2-yl)pyrim...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3cccc(-n4nccn4)c3c2[nH]1
Show InChI InChI=1S/C17H17N7O/c25-15-10-14(11-4-6-18-7-5-11)23-17(21-15)16-12(22-23)2-1-3-13(16)24-19-8-9-20-24/h1-3,8-11,18H,4-7H2,(H,21,25)
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n/an/a 27n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290288
PNG
(4-(Piperidin-4-yl)pyrido[3′,4′:3,4]pyr...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3cnccc3c2[nH]1
Show InChI InChI=1S/C14H15N5O/c20-13-7-12(9-1-4-15-5-2-9)19-14(17-13)10-3-6-16-8-11(10)18-19/h3,6-9,15H,1-2,4-5H2,(H,17,20)
PDB

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n/an/a 28n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290350
PNG
(10-(2-Ethoxyphenyl)-4-(piperidin-4-yl)pyrimido[1,2...)
Show SMILES CCOc1ccccc1-c1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C23H24N4O2/c1-2-29-20-9-4-3-6-16(20)17-7-5-8-18-22(17)23-25-21(28)14-19(27(23)26-18)15-10-12-24-13-11-15/h3-9,14-15,24H,2,10-13H2,1H3,(H,25,28)
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n/an/a 28n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290263
PNG
(10-Fluoro-4-(piperidin-4-yl)pyrimido[1,2-b]indazol...)
Show SMILES Fc1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C15H15FN4O/c16-10-2-1-3-11-14(10)15-18-13(21)8-12(20(15)19-11)9-4-6-17-7-5-9/h1-3,8-9,17H,4-7H2,(H,18,21)
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n/an/a 28n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290282
PNG
(8,10-Difluoro-4-(piperidin-4-yl)pyrimido[1,2-b]ind...)
Show SMILES Fc1cc(F)c2c(c1)nn1c(cc(=O)[nH]c21)C1CCNCC1
Show InChI InChI=1S/C15H14F2N4O/c16-9-5-10(17)14-11(6-9)20-21-12(7-13(22)19-15(14)21)8-1-3-18-4-2-8/h5-8,18H,1-4H2,(H,19,22)
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n/an/a 28n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290262
PNG
(10-Chloro-4-(piperidin-4-yl)pyrimido[1,2-b]indazol...)
Show SMILES Clc1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C15H15ClN4O/c16-10-2-1-3-11-14(10)15-18-13(21)8-12(20(15)19-11)9-4-6-17-7-5-9/h1-3,8-9,17H,4-7H2,(H,18,21)
PDB

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n/an/a 28n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290285
PNG
(10-Ethoxy-4-(piperidin-4-yl)pyrimido[1,2-b]indazol...)
Show SMILES CCOc1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C17H20N4O2/c1-2-23-14-5-3-4-12-16(14)17-19-15(22)10-13(21(17)20-12)11-6-8-18-9-7-11/h3-5,10-11,18H,2,6-9H2,1H3,(H,19,22)
PDB

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n/an/a 29n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290356
PNG
(4-(Piperidin-4-yl)-10-(1H-1,2,3-triazol-1-yl)pyrim...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3cccc(-n4ccnn4)c3c2[nH]1
Show InChI InChI=1S/C17H17N7O/c25-15-10-14(11-4-6-18-7-5-11)24-17(20-15)16-12(21-24)2-1-3-13(16)23-9-8-19-22-23/h1-3,8-11,18H,4-7H2,(H,20,25)
PDB

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n/an/a 29n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290280
PNG
(8-Bromo-4-(piperidin-4-yl)pyrimido[1,2-b]indazol-2...)
Show SMILES Brc1ccc2c(c1)nn1c(cc(=O)[nH]c21)C1CCNCC1
Show InChI InChI=1S/C15H15BrN4O/c16-10-1-2-11-12(7-10)19-20-13(8-14(21)18-15(11)20)9-3-5-17-6-4-9/h1-2,7-9,17H,3-6H2,(H,18,21)
PDB

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n/an/a 30n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290357
PNG
(10-Chloro-7-methyl-4-(piperidin-4-yl)pyrimido[1,2-...)
Show SMILES Cc1ccc(Cl)c2c1nn1c(cc(=O)[nH]c21)C1CCNCC1
Show InChI InChI=1S/C16H17ClN4O/c1-9-2-3-11(17)14-15(9)20-21-12(8-13(22)19-16(14)21)10-4-6-18-7-5-10/h2-3,8,10,18H,4-7H2,1H3,(H,19,22)
PDB

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n/an/a 30n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290261
PNG
(4-(Piperidin-4-yl)-9-(trifluoromethyl)pyrimido[1,2...)
Show SMILES FC(F)(F)c1ccc2nn3c(cc(=O)[nH]c3c2c1)C1CCNCC1
Show InChI InChI=1S/C16H15F3N4O/c17-16(18,19)10-1-2-12-11(7-10)15-21-14(24)8-13(23(15)22-12)9-3-5-20-6-4-9/h1-2,7-9,20H,3-6H2,(H,21,24)
PDB

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n/an/a 30n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290354
PNG
(10-(2-Fluoro-6-methoxyphenyl)-4-(piperidin-4-yl)py...)
Show SMILES COc1cccc(F)c1-c1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C22H21FN4O2/c1-29-18-7-3-5-15(23)20(18)14-4-2-6-16-21(14)22-25-19(28)12-17(27(22)26-16)13-8-10-24-11-9-13/h2-7,12-13,24H,8-11H2,1H3,(H,25,28)
PDB

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n/an/a 30n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290272
PNG
(8-tert-Butyl-4-(piperidin-4-yl)pyrido[2′,3&#...)
Show SMILES CC(C)(C)c1ccc2c(nn3c(cc(=O)[nH]c23)C2CCNCC2)n1
Show InChI InChI=1S/C18H23N5O/c1-18(2,3)14-5-4-12-16(20-14)22-23-13(10-15(24)21-17(12)23)11-6-8-19-9-7-11/h4-5,10-11,19H,6-9H2,1-3H3,(H,21,24)
PDB

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n/an/a 31n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290271
PNG
(4-(Piperidin-4-yl)-10-(trifluoromethyl)pyrimido[1,...)
Show SMILES FC(F)(F)c1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C16H15F3N4O/c17-16(18,19)10-2-1-3-11-14(10)15-21-13(24)8-12(23(15)22-11)9-4-6-20-7-5-9/h1-3,8-9,20H,4-7H2,(H,21,24)
PDB

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n/an/a 32n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290287
PNG
(7-Fluoro-4-(piperidin-4-yl)pyrimido[1,2-b]indazol-...)
Show SMILES Fc1cccc2c1nn1c(cc(=O)[nH]c21)C1CCNCC1
Show InChI InChI=1S/C15H15FN4O/c16-11-3-1-2-10-14(11)19-20-12(8-13(21)18-15(10)20)9-4-6-17-7-5-9/h1-3,8-9,17H,4-7H2,(H,18,21)
PDB

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n/an/a 33n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290283
PNG
(8-Methyl-4-(piperidin-4-yl)pyrido[2′,3′...)
Show SMILES Cc1ccc2c(nn3c(cc(=O)[nH]c23)C2CCNCC2)n1
Show InChI InChI=1S/C15H17N5O/c1-9-2-3-11-14(17-9)19-20-12(8-13(21)18-15(11)20)10-4-6-16-7-5-10/h2-3,8,10,16H,4-7H2,1H3,(H,18,21)
PDB

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n/an/a 34n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290363
PNG
(4-(piperidin-4-yl)-10-(2,2,2-trifluoroethoxy)pyrim...)
Show SMILES FC(F)(F)COc1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C17H17F3N4O2/c18-17(19,20)9-26-13-3-1-2-11-15(13)16-22-14(25)8-12(24(16)23-11)10-4-6-21-7-5-10/h1-3,8,10,21H,4-7,9H2,(H,22,25)
PDB

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n/an/a 34n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290269
PNG
(10-Bromo-4-(piperidin-4-yl)pyrimido[1,2-b]indazol-...)
Show SMILES Brc1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C15H15BrN4O/c16-10-2-1-3-11-14(10)15-18-13(21)8-12(20(15)19-11)9-4-6-17-7-5-9/h1-3,8-9,17H,4-7H2,(H,18,21)
PDB

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n/an/a 34n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290275
PNG
(8-Amino-4-(piperidin-4-yl)pyrimido[1,2-b]indazol-2...)
Show SMILES Nc1ccc2c(c1)nn1c(cc(=O)[nH]c21)C1CCNCC1
Show InChI InChI=1S/C15H17N5O/c16-10-1-2-11-12(7-10)19-20-13(8-14(21)18-15(11)20)9-3-5-17-6-4-9/h1-2,7-9,17H,3-6,16H2,(H,18,21)
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n/an/a 34n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290364
PNG
(10-amino-4-(piperidin-4-yl)pyrimido[1,2-b]indazol-...)
Show SMILES Nc1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C15H17N5O/c16-10-2-1-3-11-14(10)15-18-13(21)8-12(20(15)19-11)9-4-6-17-7-5-9/h1-3,8-9,17H,4-7,16H2,(H,18,21)
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n/an/a 35n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290327
PNG
(10-Bromo-9-fluoro-4-(piperidin-4-yl)pyrimido[1,2-b...)
Show SMILES Fc1ccc2nn3c(cc(=O)[nH]c3c2c1Br)C1CCNCC1
Show InChI InChI=1S/C15H14BrFN4O/c16-14-9(17)1-2-10-13(14)15-19-12(22)7-11(21(15)20-10)8-3-5-18-6-4-8/h1-2,7-8,18H,3-6H2,(H,19,22)
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n/an/a 35n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290351
PNG
(10-(2-Isopropoxyphenyl)-4-(piperidin-4-yl)pyrimido...)
Show SMILES CC(C)Oc1ccccc1-c1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C24H26N4O2/c1-15(2)30-21-9-4-3-6-17(21)18-7-5-8-19-23(18)24-26-22(29)14-20(28(24)27-19)16-10-12-25-13-11-16/h3-9,14-16,25H,10-13H2,1-2H3,(H,26,29)
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n/an/a 35n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290360
PNG
(4-(piperidin-4-yl)-10-(1H-pyrrol-2-yl)pyrimido[1,2...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3cccc(-c4ccc[nH]4)c3c2[nH]1
Show InChI InChI=1S/C19H19N5O/c25-17-11-16(12-6-9-20-10-7-12)24-19(22-17)18-13(14-5-2-8-21-14)3-1-4-15(18)23-24/h1-5,8,11-12,20-21H,6-7,9-10H2,(H,22,25)
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n/an/a 35n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290325
PNG
((−)-trans-10-Chloro-4-(2-methylpiperidin-4-y...)
Show SMILES CC1CC(CCN1)c1cc(=O)[nH]c2c3c(Cl)cccc3nn12
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n/an/a 35n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290346
PNG
(10-Bromo-8-methyl-4-(piperidin-4-yl)pyrimido[1,2-b...)
Show SMILES Cc1cc(Br)c2c(c1)nn1c(cc(=O)[nH]c21)C1CCNCC1
Show InChI InChI=1S/C16H17BrN4O/c1-9-6-11(17)15-12(7-9)20-21-13(8-14(22)19-16(15)21)10-2-4-18-5-3-10/h6-8,10,18H,2-5H2,1H3,(H,19,22)
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n/an/a 36n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290268
PNG
(7-(Piperidin-4-yl)pyrido[3′,2′:3,4]pyr...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3cccnc3c2[nH]1
Show InChI InChI=1S/C14H15N5O/c20-12-8-11(9-3-6-15-7-4-9)19-14(17-12)13-10(18-19)2-1-5-16-13/h1-2,5,8-9,15H,3-4,6-7H2,(H,17,20)
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n/an/a 36n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM445019
PNG
(9-Iodo-4-(piperidin-4-yl)pyrimido[1,2-b]indazol-2(...)
Show SMILES Ic1cnc2nn3c(cc(=O)[nH]c3c2c1)C1CCNCC1
Show InChI InChI=1S/C14H14IN5O/c15-9-5-10-13(17-7-9)19-20-11(6-12(21)18-14(10)20)8-1-3-16-4-2-8/h5-8,16H,1-4H2,(H,18,21)
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n/an/a 36n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290306
PNG
(4-(Piperidin-4-yl)pyrido[4′,3′:3,4]pyr...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3ccncc3c2[nH]1
Show InChI InChI=1S/C14H15N5O/c20-13-7-12(9-1-4-15-5-2-9)19-14(17-13)10-8-16-6-3-11(10)18-19/h3,6-9,15H,1-2,4-5H2,(H,17,20)
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n/an/a 36n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290264
PNG
(9-Chloro-4-(piperidin-4-yl)pyrimido[1,2-b]indazol-...)
Show SMILES Clc1ccc2nn3c(cc(=O)[nH]c3c2c1)C1CCNCC1
Show InChI InChI=1S/C15H15ClN4O/c16-10-1-2-12-11(7-10)15-18-14(21)8-13(20(15)19-12)9-3-5-17-6-4-9/h1-2,7-9,17H,3-6H2,(H,18,21)
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n/an/a 37n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290302
PNG
(9-Phenyl-4-(piperidin-4-yl)pyrido[2′,3′...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3ncc(cc3c2[nH]1)-c1ccccc1
Show InChI InChI=1S/C20H19N5O/c26-18-11-17(14-6-8-21-9-7-14)25-20(23-18)16-10-15(12-22-19(16)24-25)13-4-2-1-3-5-13/h1-5,10-12,14,21H,6-9H2,(H,23,26)
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n/an/a 37n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290277
PNG
(8-Fluoro-4-(piperidin-4-yl)pyrimido[1,2-b]indazol-...)
Show SMILES Fc1ccc2c(c1)nn1c(cc(=O)[nH]c21)C1CCNCC1
Show InChI InChI=1S/C15H15FN4O/c16-10-1-2-11-12(7-10)19-20-13(8-14(21)18-15(11)20)9-3-5-17-6-4-9/h1-2,7-9,17H,3-6H2,(H,18,21)
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n/an/a 38n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290297
PNG
(10-(Dimethylamino)-4-(piperidin-4-yl)pyrido[2̸...)
Show SMILES CN(C)c1ccnc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C16H20N6O/c1-21(2)11-5-8-18-15-14(11)16-19-13(23)9-12(22(16)20-15)10-3-6-17-7-4-10/h5,8-10,17H,3-4,6-7H2,1-2H3,(H,19,23)
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n/an/a 38n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290340
PNG
(4-(Piperidin-4-yl)-10-(1,3-thiazol-2-yl)pyrimido[1...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3cccc(-c4nccs4)c3c2[nH]1
Show InChI InChI=1S/C18H17N5OS/c24-15-10-14(11-4-6-19-7-5-11)23-17(21-15)16-12(18-20-8-9-25-18)2-1-3-13(16)22-23/h1-3,8-11,19H,4-7H2,(H,21,24)
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n/an/a 41n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290294
PNG
(4-(Piperidin-4-yl)-10-(trifluoromethoxy)pyrimido[1...)
Show SMILES FC(F)(F)Oc1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C16H15F3N4O2/c17-16(18,19)25-12-3-1-2-10-14(12)15-21-13(24)8-11(23(15)22-10)9-4-6-20-7-5-9/h1-3,8-9,20H,4-7H2,(H,21,24)
PDB

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n/an/a 44n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290289
PNG
(4-(Piperidin-4-yl)-7-(trifluoromethyl)pyrimido[1,2...)
Show SMILES FC(F)(F)c1cccc2c1nn1c(cc(=O)[nH]c21)C1CCNCC1
Show InChI InChI=1S/C16H15F3N4O/c17-16(18,19)11-3-1-2-10-14(11)22-23-12(8-13(24)21-15(10)23)9-4-6-20-7-5-9/h1-3,8-9,20H,4-7H2,(H,21,24)
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n/an/a 46n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290267
PNG
(10-Methoxy-4-(piperidin-4-yl)pyrimido[1,2-b]indazo...)
Show SMILES COc1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C16H18N4O2/c1-22-13-4-2-3-11-15(13)16-18-14(21)9-12(20(16)19-11)10-5-7-17-8-6-10/h2-4,9-10,17H,5-8H2,1H3,(H,18,21)
PDB

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n/an/a 46n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290274
PNG
(9-Methyl-4-(piperidin-4-yl)pyrimido[1,2-b]indazol-...)
Show SMILES Cc1ccc2nn3c(cc(=O)[nH]c3c2c1)C1CCNCC1
Show InChI InChI=1S/C16H18N4O/c1-10-2-3-13-12(8-10)16-18-15(21)9-14(20(16)19-13)11-4-6-17-7-5-11/h2-3,8-9,11,17H,4-7H2,1H3,(H,18,21)
PDB

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n/an/a 48n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290301
PNG
(8-Phenyl-4-(piperidin-4-yl)pyrido[2′,3′...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3nc(ccc3c2[nH]1)-c1ccccc1
Show InChI InChI=1S/C20H19N5O/c26-18-12-17(14-8-10-21-11-9-14)25-20(23-18)15-6-7-16(22-19(15)24-25)13-4-2-1-3-5-13/h1-7,12,14,21H,8-11H2,(H,23,26)
PDB

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n/an/a 48n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM444987
PNG
(10-Methyl-4-(piperidin-4-yl)-8-(trifluoromethyl)py...)
Show SMILES Cc1cc(nc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1)C(F)(F)F
Show InChI InChI=1S/C16H16F3N5O/c1-8-6-11(16(17,18)19)21-14-13(8)15-22-12(25)7-10(24(15)23-14)9-2-4-20-5-3-9/h6-7,9,20H,2-5H2,1H3,(H,22,25)
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n/an/a 50n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290260
PNG
(4-(Piperidin-4-yl)pyrimido[1,2-b]indazol-2(1H)-one...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3ccccc3c2[nH]1
Show InChI InChI=1S/C15H16N4O/c20-14-9-13(10-5-7-16-8-6-10)19-15(17-14)11-3-1-2-4-12(11)18-19/h1-4,9-10,16H,5-8H2,(H,17,20)
PDB

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n/an/a 51n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290295
PNG
(7-(Piperidin-4-yl)pyrazino[2′,3′:3,4]p...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3nccnc3c2[nH]1
Show InChI InChI=1S/C13H14N6O/c20-10-7-9(8-1-3-14-4-2-8)19-13(17-10)11-12(18-19)16-6-5-15-11/h5-8,14H,1-4H2,(H,17,20)
PDB

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n/an/a 60n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290361
PNG
(10-hydroxy-4-(piperidin-4-yl)pyrimido[1,2-b]indazo...)
Show SMILES Oc1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C15H16N4O2/c20-12-3-1-2-10-14(12)15-17-13(21)8-11(19(15)18-10)9-4-6-16-7-5-9/h1-3,8-9,16,20H,4-7H2,(H,17,21)
PDB

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n/an/a 74n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290265
PNG
(7,9-Dichloro-4-(piperidin-4-yl)pyrimido[1,2-b]inda...)
Show SMILES Clc1cc(Cl)c2nn3c(cc(=O)[nH]c3c2c1)C1CCNCC1
Show InChI InChI=1S/C15H14Cl2N4O/c16-9-5-10-14(11(17)6-9)20-21-12(7-13(22)19-15(10)21)8-1-3-18-4-2-8/h5-8,18H,1-4H2,(H,19,22)
PDB

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n/an/a 94n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290266
PNG
(9-Fluoro-4-(piperidin-4-yl)pyrimido[1,2-b]indazol-...)
Show SMILES Fc1ccc2nn3c(cc(=O)[nH]c3c2c1)C1CCNCC1
Show InChI InChI=1S/C15H15FN4O/c16-10-1-2-12-11(7-10)15-18-14(21)8-13(20(15)19-12)9-3-5-17-6-4-9/h1-2,7-9,17H,3-6H2,(H,18,21)
PDB

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UniChem
US Patent
n/an/a 95n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290290
PNG
(10-Nitro-4-(piperidin-4-yl)-8-(trifluoromethyl)pyr...)
Show SMILES [O-][N+](=O)c1cc(cc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1)C(F)(F)F
Show InChI InChI=1S/C16H14F3N5O3/c17-16(18,19)9-5-10-14(12(6-9)24(26)27)15-21-13(25)7-11(23(15)22-10)8-1-3-20-4-2-8/h5-8,20H,1-4H2,(H,21,25)
PDB

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UniChem
US Patent
n/an/a 97n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290300
PNG
(10-Bromo-4-(piperidin-4-yl)pyrido[3′,4′...)
Show SMILES Brc1cncc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C14H14BrN5O/c15-9-6-17-7-10-13(9)14-18-12(21)5-11(20(14)19-10)8-1-3-16-4-2-8/h5-8,16H,1-4H2,(H,18,21)
PDB

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UniChem
US Patent
n/an/a 100n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290299
PNG
(8-(4-Fluorophenyl)-4-(piperidin-4-yl)-10-(trifluor...)
Show SMILES Fc1ccc(cc1)-c1cc(c2c(nn3c(cc(=O)[nH]c23)C2CCNCC2)n1)C(F)(F)F
Show InChI InChI=1S/C21H17F4N5O/c22-13-3-1-11(2-4-13)15-9-14(21(23,24)25)18-19(27-15)29-30-16(10-17(31)28-20(18)30)12-5-7-26-8-6-12/h1-4,9-10,12,26H,5-8H2,(H,28,31)
PDB

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UniChem
US Patent
n/an/a 110n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290359
PNG
(10-(1H-imidazol-5-yl)-4-(piperidin-4-yl)pyrimido[1...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3cccc(-c4cnc[nH]4)c3c2[nH]1
Show InChI InChI=1S/C18H18N6O/c25-16-8-15(11-4-6-19-7-5-11)24-18(22-16)17-12(14-9-20-10-21-14)2-1-3-13(17)23-24/h1-3,8-11,19H,4-7H2,(H,20,21)(H,22,25)
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US Patent
n/an/a 110n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290291
PNG
(8,10-Dimethyl-4-(piperidin-4-yl)pyrido[2′,3&...)
Show SMILES Cc1cc(C)c2c(nn3c(cc(=O)[nH]c23)C2CCNCC2)n1
Show InChI InChI=1S/C16H19N5O/c1-9-7-10(2)18-15-14(9)16-19-13(22)8-12(21(16)20-15)11-3-5-17-6-4-11/h7-8,11,17H,3-6H2,1-2H3,(H,19,22)
PDB

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UniChem
US Patent
n/an/a 210n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
Plasminogen (aa 101-181)


(Homo sapiens (Human))
BDBM290362
PNG
(2-oxo-4-(piperidin-4-yl)-1,2-dihydropyrimido[1,2-b...)
Show SMILES OC(=O)c1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C16H16N4O3/c21-13-8-12(9-4-6-17-7-5-9)20-15(18-13)14-10(16(22)23)2-1-3-11(14)19-20/h1-3,8-9,17H,4-7H2,(H,18,21)(H,22,23)
PDB

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US Patent
n/an/a 420n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...


US Patent US10668071 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%