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Patent code US10669234

Compile Data Set for Download or QSAR
Found 193 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445113
PNG
((S)-N-(4-(3-chlorophenyl)- thiazol-2-yl)-1-cyano-N...)
Show SMILES CN(C(=O)[C@@H]1CCCN1C#N)c1nc(cs1)-c1cccc(Cl)c1
Show InChI InChI=1S/C16H15ClN4OS/c1-20(15(22)14-6-3-7-21(14)10-18)16-19-13(9-23-16)11-4-2-5-12(17)8-11/h2,4-5,8-9,14H,3,6-7H2,1H3/t14-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445158
PNG
((S)-2-(5-(3-(trifluoro- methyl)-1H-pyrazol-4- yl)i...)
Show SMILES FC(F)(F)c1n[nH]cc1-c1ccc2CN(Cc2c1)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C18H16F3N5O/c19-18(20,21)16-14(7-23-24-16)11-3-4-12-8-26(9-13(12)6-11)17(27)15-2-1-5-25(15)10-22/h3-4,6-7,15H,1-2,5,8-9H2,(H,23,24)/t15-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445090
PNG
((2S,4S)-4-fluoro-2-(4-(5-(trifluoromethyl)-1H-pyra...)
Show SMILES F[C@H]1C[C@H](N(C1)C#N)C(=O)N1CCc2c1cccc2-c1cn[nH]c1C(F)(F)F
Show InChI InChI=1S/C18H15F4N5O/c19-10-6-15(26(8-10)9-23)17(28)27-5-4-12-11(2-1-3-14(12)27)13-7-24-25-16(13)18(20,21)22/h1-3,7,10,15H,4-6,8H2,(H,24,25)/t10-,15-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445088
PNG
((S)-2-(4-(1H-pyrrolo [2,3-b]pyridin-3- yl)indoline...)
Show SMILES O=C([C@@H]1CCCN1C#N)N1CCc2c1cccc2-c1c[nH]c2ncccc12
Show InChI InChI=1S/C21H19N5O/c22-13-25-10-3-7-19(25)21(27)26-11-8-15-14(4-1-6-18(15)26)17-12-24-20-16(17)5-2-9-23-20/h1-2,4-6,9,12,19H,3,7-8,10-11H2,(H,23,24)/t19-/m0/s1
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445160
PNG
((S)-2-(4-(1H-pyrrolo[2,3-b]- pyridin-4-yl)indoline...)
Show SMILES O=C([C@@H]1CCCN1C#N)N1CCc2c1cccc2-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C21H19N5O/c22-13-25-11-2-5-19(25)21(27)26-12-8-16-14(3-1-4-18(16)26)15-6-9-23-20-17(15)7-10-24-20/h1,3-4,6-7,9-10,19H,2,5,8,11-12H2,(H,23,24)/t19-/m0/s1
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445171
PNG
((S)-1-cyano-N-(4- (6-cyano-3- methylpyridin-2- yl)...)
Show SMILES CN(C(=O)[C@@H]1CCCN1C#N)c1nc(cs1)-c1nc(ccc1C)C#N
Show InChI InChI=1S/C17H16N6OS/c1-11-5-6-12(8-18)20-15(11)13-9-25-17(21-13)22(2)16(24)14-4-3-7-23(14)10-19/h5-6,9,14H,3-4,7H2,1-2H3/t14-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445173
PNG
((S)-1-Cyano-N-(4-(6-cyano-5-methoxypyridin-2-yl)th...)
Show SMILES COc1ccc(nc1C#N)-c1csc(n1)N(C)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C17H16N6O2S/c1-22(16(24)14-4-3-7-23(14)10-19)17-21-13(9-26-17)11-5-6-15(25-2)12(8-18)20-11/h5-6,9,14H,3-4,7H2,1-2H3/t14-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445168
PNG
((S)-1-cyano-N-methyl-N-(4- (3-(trifluoromethyl)phe...)
Show SMILES CN(C(=O)[C@@H]1CCCN1C#N)c1nc(cs1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C17H15F3N4OS/c1-23(15(25)14-6-3-7-24(14)10-21)16-22-13(9-26-16)11-4-2-5-12(8-11)17(18,19)20/h2,4-5,8-9,14H,3,6-7H2,1H3/t14-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445188
PNG
((S)-1-cyano-N-(4-(3- ethylphenyl)thiazol-2-yl)- N-...)
Show SMILES CCc1cccc(c1)-c1csc(n1)N(C)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C18H20N4OS/c1-3-13-6-4-7-14(10-13)15-11-24-18(20-15)21(2)17(23)16-8-5-9-22(16)12-19/h4,6-7,10-11,16H,3,5,8-9H2,1-2H3/t16-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445203
PNG
((S)-1-cyano-N-(4-(6-cyano-3-ethoxypyridin-2-yl)thi...)
Show SMILES CCOc1ccc(nc1-c1csc(n1)N(C)C(=O)[C@@H]1CCCN1C#N)C#N
Show InChI InChI=1S/C18H18N6O2S/c1-3-26-15-7-6-12(9-19)21-16(15)13-10-27-18(22-13)23(2)17(25)14-5-4-8-24(14)11-20/h6-7,10,14H,3-5,8H2,1-2H3/t14-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445170
PNG
((S)-1-Cyano-N-(4-(6-cyanopyridin-2-yl)thiazol-2-yl...)
Show SMILES CN(C(=O)[C@@H]1CCCN1C#N)c1nc(cs1)-c1cccc(n1)C#N
Show InChI InChI=1S/C16H14N6OS/c1-21(15(23)14-6-3-7-22(14)10-18)16-20-13(9-24-16)12-5-2-4-11(8-17)19-12/h2,4-5,9,14H,3,6-7H2,1H3/t14-/m0/s1
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445149
PNG
((2S,4S)-4-Fluoro-2-(4-(5-methyl-1H-pyrazol-4-yl)in...)
Show SMILES Cc1[nH]ncc1-c1cccc2N(CCc12)C(=O)[C@@H]1C[C@H](F)CN1C#N
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445198
PNG
((S)-1-cyano-N-(4- (6-cyano-3- methoxypyridin- 2-yl...)
Show SMILES COc1ccc(nc1-c1csc(n1)N(C)C(=O)[C@@H]1CCCN1C#N)C#N
Show InChI InChI=1S/C17H16N6O2S/c1-22(16(24)13-4-3-7-23(13)10-19)17-21-12(9-26-17)15-14(25-2)6-5-11(8-18)20-15/h5-6,9,13H,3-4,7H2,1-2H3/t13-/m0/s1
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445080
PNG
((S)-2-(4-(5-(Trifluoromethyl)-1H-pyrazol-4-yl)indo...)
Show SMILES FC(F)(F)c1[nH]ncc1-c1cccc2N(CCc12)C(=O)[C@@H]1CCCN1C#N
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445201
PNG
((S)-1-cyano-N-(4-(6-cyano-5-(dimethylamino)pyridin...)
Show SMILES CN(C)c1ccc(nc1C#N)-c1csc(n1)N(C)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C18H19N7OS/c1-23(2)15-7-6-12(21-13(15)9-19)14-10-27-18(22-14)24(3)17(26)16-5-4-8-25(16)11-20/h6-7,10,16H,4-5,8H2,1-3H3/t16-/m0/s1
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445163
PNG
((S)-2-(4-(2- (methylamino)pyrimidin- 4-yl)indoline...)
Show SMILES CNc1nccc(n1)-c1cccc2N(CCc12)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C19H20N6O/c1-21-19-22-9-7-15(23-19)13-4-2-5-16-14(13)8-11-25(16)18(26)17-6-3-10-24(17)12-20/h2,4-5,7,9,17H,3,6,8,10-11H2,1H3,(H,21,22,23)/t17-/m0/s1
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445148
PNG
((S)-2-(6-(5-Methyl-4H-1,2,4-triazol-3-yl)-4-phenyl...)
Show SMILES Cc1nnc([nH]1)-c1cc2N(CCc2c(c1)-c1ccccc1)C(=O)[C@@H]1CCCN1C#N
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445115
PNG
((S)-1-cyano-N-methyl-N-(4-phenylthiazol-2-yl)pyrro...)
Show SMILES CN(C(=O)[C@@H]1CCCN1C#N)c1nc(cs1)-c1ccccc1
Show InChI InChI=1S/C16H16N4OS/c1-19(15(21)14-8-5-9-20(14)11-17)16-18-13(10-22-16)12-6-3-2-4-7-12/h2-4,6-7,10,14H,5,8-9H2,1H3/t14-/m0/s1
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445132
PNG
((2S,4S)-1-Cyano-4-methoxy-N-methyl-N-(4-phenylthia...)
Show SMILES CO[C@H]1C[C@H](N(C1)C(=O)OC(C)(C)C)C(=O)N(C)c1nc(cs1)-c1ccccc1
Show InChI InChI=1S/C21H27N3O4S/c1-21(2,3)28-20(26)24-12-15(27-5)11-17(24)18(25)23(4)19-22-16(13-29-19)14-9-7-6-8-10-14/h6-10,13,15,17H,11-12H2,1-5H3/t15-,17-/m0/s1
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445175
PNG
((S)-2-(4-(4-Cyanophenyl)-6-(5-methyl-4H-1,2,4-tria...)
Show SMILES Cc1nnc([nH]1)-c1cc2N(CCc2c(c1)-c1ccc(cc1)C#N)C(=O)[C@@H]1CCCN1C#N
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445205
PNG
((S)-1-cyano-N-(4-(6-cyanopyridin-2-yl)-5-methylthi...)
Show SMILES CN(C(=O)[C@@H]1CCCN1C#N)c1nc(c(C)s1)-c1cccc(n1)C#N
Show InChI InChI=1S/C17H16N6OS/c1-11-15(13-6-3-5-12(9-18)20-13)21-17(25-11)22(2)16(24)14-7-4-8-23(14)10-19/h3,5-6,14H,4,7-8H2,1-2H3/t14-/m0/s1
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445081
PNG
((S)-2-(4-(1H-Pyrazol-4-yl)indoline-1-carbonyl)pyrr...)
Show SMILES O=C([C@@H]1CCCN1C#N)N1CCc2c1cccc2-c1cn[nH]c1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445114
PNG
((S)-N-(4-(2-chlorophenyl)- thiazol-2-yl)-1-cyano-N...)
Show SMILES CN(C(=O)[C@@H]1CCCN1C#N)c1nc(cs1)-c1ccccc1Cl
Show InChI InChI=1S/C16H15ClN4OS/c1-20(15(22)14-7-4-8-21(14)10-18)16-19-13(9-23-16)11-5-2-3-6-12(11)17/h2-3,5-6,9,14H,4,7-8H2,1H3/t14-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445155
PNG
((S)-N-(4-(3-Chlorophenyl)thiazol-2-yl)-1-cyano-N-e...)
Show SMILES CCN(C(=O)[C@@H]1CCCN1C(=O)OC(C)(C)C)c1nc(cs1)-c1cccc(Cl)c1
Show InChI InChI=1S/C21H26ClN3O3S/c1-5-24(19-23-16(13-29-19)14-8-6-9-15(22)12-14)18(26)17-10-7-11-25(17)20(27)28-21(2,3)4/h6,8-9,12-13,17H,5,7,10-11H2,1-4H3/t17-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445167
PNG
((S)-N-(4-(3-chloro-4- fluorophenyl)thiazol-2-yl)-1...)
Show SMILES CN(C(=O)[C@@H]1CCCN1C#N)c1nc(cs1)-c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C16H14ClFN4OS/c1-21(15(23)14-3-2-6-22(14)9-19)16-20-13(8-24-16)10-4-5-12(18)11(17)7-10/h4-5,7-8,14H,2-3,6H2,1H3/t14-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445169
PNG
((S)-1-cyano-N-(4-(3- cyanophenyl)thiazol-2-yl)- N-...)
Show SMILES CN(C(=O)[C@@H]1CCCN1C#N)c1nc(cs1)-c1cccc(c1)C#N
Show InChI InChI=1S/C17H15N5OS/c1-21(16(23)15-6-3-7-22(15)11-19)17-20-14(10-24-17)13-5-2-4-12(8-13)9-18/h2,4-5,8,10,15H,3,6-7H2,1H3/t15-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445159
PNG
(4-(1-(cyano-L-prolyl)indolin- 4-yl)nicotinonitrile...)
Show SMILES O=C([C@@H]1CCCN1C#N)N1CCc2c1cccc2-c1ccncc1C#N
Show InChI InChI=1S/C20H17N5O/c21-11-14-12-23-8-6-15(14)16-3-1-4-18-17(16)7-10-25(18)20(26)19-5-2-9-24(19)13-22/h1,3-4,6,8,12,19H,2,5,7,9-10H2/t19-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445107
PNG
((S)-1-Cyano-N-(4-(2-methoxyphenyl)thiazol-2-yl)-N-...)
Show SMILES COc1ccccc1-c1csc(n1)N(C)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C17H18N4O2S/c1-20(16(22)14-7-5-9-21(14)11-18)17-19-13(10-24-17)12-6-3-4-8-15(12)23-2/h3-4,6,8,10,14H,5,7,9H2,1-2H3/t14-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445138
PNG
((S)-1-cyano-N-(4-(2- cyanopyridin-4- yl)thiazol-2-...)
Show SMILES CN(C(=O)[C@@H]1CCCN1C#N)c1nc(cs1)-c1ccnc(c1)C#N
Show InChI InChI=1S/C16H14N6OS/c1-21(15(23)14-3-2-6-22(14)10-18)16-20-13(9-24-16)11-4-5-19-12(7-11)8-17/h4-5,7,9,14H,2-3,6H2,1H3/t14-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445172
PNG
((S)-1-cyano-N- methyl-N-(4-(6- (trifluoromethyl)- ...)
Show SMILES CN(C(=O)[C@@H]1CCCN1C#N)c1nc(cs1)-c1cccc(n1)C(F)(F)F
Show InChI InChI=1S/C16H14F3N5OS/c1-23(14(25)12-5-3-7-24(12)9-20)15-22-11(8-26-15)10-4-2-6-13(21-10)16(17,18)19/h2,4,6,8,12H,3,5,7H2,1H3/t12-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445155
PNG
((S)-N-(4-(3-Chlorophenyl)thiazol-2-yl)-1-cyano-N-e...)
Show SMILES CCN(C(=O)[C@@H]1CCCN1C(=O)OC(C)(C)C)c1nc(cs1)-c1cccc(Cl)c1
Show InChI InChI=1S/C21H26ClN3O3S/c1-5-24(19-23-16(13-29-19)14-8-6-9-15(22)12-14)18(26)17-10-7-11-25(17)20(27)28-21(2,3)4/h6,8-9,12-13,17H,5,7,10-11H2,1-4H3/t17-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445194
PNG
((S)-2-(5-(3-nitrophenyl)- isoindoline-2-carbonyl)-...)
Show SMILES [O-][N+](=O)c1cccc(c1)-c1ccc2CN(Cc2c1)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C20H18N4O3/c21-13-22-8-2-5-19(22)20(25)23-11-16-7-6-15(9-17(16)12-23)14-3-1-4-18(10-14)24(26)27/h1,3-4,6-7,9-10,19H,2,5,8,11-12H2/t19-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445150
PNG
(N-(4-(1-(Cyano-L-prolyl)indolin-4-yl)pyridin-2-yl)...)
Show SMILES CC(=O)Nc1cc(ccn1)-c1cccc2N(CCc12)C(=O)[C@@H]1CCCN1C(=O)OC(C)(C)C
Show InChI InChI=1S/C25H30N4O4/c1-16(30)27-22-15-17(10-12-26-22)18-7-5-8-20-19(18)11-14-28(20)23(31)21-9-6-13-29(21)24(32)33-25(2,3)4/h5,7-8,10,12,15,21H,6,9,11,13-14H2,1-4H3,(H,26,27,30)/t21-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445086
PNG
((S)-2-(4-(3,5-dimethyl- 1H-pyrazol-4-yl)indoline- ...)
Show SMILES Cc1n[nH]c(C)c1-c1cccc2N(CCc12)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C19H21N5O/c1-12-18(13(2)22-21-12)15-5-3-6-16-14(15)8-10-24(16)19(25)17-7-4-9-23(17)11-20/h3,5-6,17H,4,7-10H2,1-2H3,(H,21,22)/t17-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445089
PNG
((S)-4,4-difluoro-2-(4-(5-(trifluoromethyl)-1H-pyra...)
Show SMILES FC(F)(F)c1[nH]ncc1-c1cccc2N(CCc12)C(=O)[C@@H]1CC(F)(F)CN1C#N
Show InChI InChI=1S/C18H14F5N5O/c19-17(20)6-14(27(8-17)9-24)16(29)28-5-4-11-10(2-1-3-13(11)28)12-7-25-26-15(12)18(21,22)23/h1-3,7,14H,4-6,8H2,(H,25,26)/t14-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445187
PNG
((S)-2-(5-(3-cyanophenyl)- isoindoline-2-carbonyl)-...)
Show SMILES O=C([C@@H]1CCCN1C#N)N1Cc2ccc(cc2C1)-c1cccc(c1)C#N
Show InChI InChI=1S/C21H18N4O/c22-11-15-3-1-4-16(9-15)17-6-7-18-12-25(13-19(18)10-17)21(26)20-5-2-8-24(20)14-23/h1,3-4,6-7,9-10,20H,2,5,8,12-13H2/t20-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445169
PNG
((S)-1-cyano-N-(4-(3- cyanophenyl)thiazol-2-yl)- N-...)
Show SMILES CN(C(=O)[C@@H]1CCCN1C#N)c1nc(cs1)-c1cccc(c1)C#N
Show InChI InChI=1S/C17H15N5OS/c1-21(16(23)15-6-3-7-22(15)11-19)17-20-14(10-24-17)13-5-2-4-12(8-13)9-18/h2,4-5,8,10,15H,3,6-7H2,1H3/t15-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445100
PNG
((S)-2-(4-(Pyridin-4-yl)indoline-1-carbonyl)pyrroli...)
Show SMILES O=C([C@@H]1CCCN1C#N)N1CCc2c1cccc2-c1ccncc1
Show InChI InChI=1S/C19H18N4O/c20-13-22-11-2-5-18(22)19(24)23-12-8-16-15(3-1-4-17(16)23)14-6-9-21-10-7-14/h1,3-4,6-7,9-10,18H,2,5,8,11-12H2/t18-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445113
PNG
((S)-N-(4-(3-chlorophenyl)- thiazol-2-yl)-1-cyano-N...)
Show SMILES CN(C(=O)[C@@H]1CCCN1C#N)c1nc(cs1)-c1cccc(Cl)c1
Show InChI InChI=1S/C16H15ClN4OS/c1-20(15(22)14-6-3-7-21(14)10-18)16-19-13(9-23-16)11-4-2-5-12(17)8-11/h2,4-5,8-9,14H,3,6-7H2,1H3/t14-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445137
PNG
((S)-2-(4-(2-Aminopyridin-4-yl)indoline-1-carbonyl)...)
Show SMILES CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)N1CCc2c1cccc2-c1ccnc(N)c1
Show InChI InChI=1S/C23H28N4O3/c1-23(2,3)30-22(29)27-12-5-8-19(27)21(28)26-13-10-17-16(6-4-7-18(17)26)15-9-11-25-20(24)14-15/h4,6-7,9,11,14,19H,5,8,10,12-13H2,1-3H3,(H2,24,25)/t19-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445140
PNG
((S)-1-cyano-N-(4- (6-methoxypyridin- 2-yl)thiazol-...)
Show SMILES COc1cccc(n1)-c1csc(n1)N(C)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C16H17N5O2S/c1-20(15(22)13-6-4-8-21(13)10-17)16-19-12(9-24-16)11-5-3-7-14(18-11)23-2/h3,5,7,9,13H,4,6,8H2,1-2H3/t13-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445165
PNG
((S)-2-(4-(1H-pyrazolo[3,4- b]pyridin-3-yl)indoline...)
Show SMILES O=C([C@@H]1CCCN1C#N)N1CCc2c1cccc2-c1n[nH]c2ncccc12
Show InChI InChI=1S/C20H18N6O/c21-12-25-10-3-7-17(25)20(27)26-11-8-13-14(4-1-6-16(13)26)18-15-5-2-9-22-19(15)24-23-18/h1-2,4-6,9,17H,3,7-8,10-11H2,(H,22,23,24)/t17-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445166
PNG
((S)-2-(4-(5H-pyrrolo[2,3- b]pyrazin-7-yl)indoline-...)
Show SMILES O=C([C@@H]1CCCN1C#N)N1CCc2c1cccc2-c1c[nH]c2nccnc12
Show InChI InChI=1S/C20H18N6O/c21-12-25-9-2-5-17(25)20(27)26-10-6-14-13(3-1-4-16(14)26)15-11-24-19-18(15)22-7-8-23-19/h1,3-4,7-8,11,17H,2,5-6,9-10H2,(H,23,24)/t17-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445099
PNG
((S)-2-(4-(2-aminopyrimidin- 4-yl)indoline-1- carbo...)
Show SMILES Nc1nccc(n1)-c1cccc2N(CCc12)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C18H18N6O/c19-11-23-9-2-5-16(23)17(25)24-10-7-13-12(3-1-4-15(13)24)14-6-8-21-18(20)22-14/h1,3-4,6,8,16H,2,5,7,9-10H2,(H2,20,21,22)/t16-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445108
PNG
((S)-1-cyano-N-(4-(3- methoxyphenyl)thiazol-2- yl)-...)
Show SMILES COc1cccc(c1)-c1csc(n1)N(C)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C17H18N4O2S/c1-20(16(22)15-7-4-8-21(15)11-18)17-19-14(10-24-17)12-5-3-6-13(9-12)23-2/h3,5-6,9-10,15H,4,7-8H2,1-2H3/t15-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445145
PNG
(1-(Cyano-L-prolyl)-N-methyl-4-(1H-pyrrolo[2,3-b]py...)
Show SMILES CNC(=O)c1cc2N(CCc2c(c1)-c1c[nH]c2ncccc12)C(=O)[C@@H]1CCCN1C#N
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445122
PNG
((S)-N-(4-(4- chlorophenyl)thiazol- 2-yl)-1-cyano-N...)
Show SMILES CN(C(=O)[C@@H]1CCCN1C#N)c1nc(cs1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C16H15ClN4OS/c1-20(15(22)14-3-2-8-21(14)10-18)16-19-13(9-23-16)11-4-6-12(17)7-5-11/h4-7,9,14H,2-3,8H2,1H3/t14-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445139
PNG
((S)-1-cyano-N-(4- (4-cyanopyridin-2- yl)thiazol-2-...)
Show SMILES CN(C(=O)[C@@H]1CCCN1C#N)c1nc(cs1)-c1cc(ccn1)C#N
Show InChI InChI=1S/C16H14N6OS/c1-21(15(23)14-3-2-6-22(14)10-18)16-20-13(9-24-16)12-7-11(8-17)4-5-19-12/h4-5,7,9,14H,2-3,6H2,1H3/t14-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445176
PNG
((S)-2-(4-(3-Cyanophenyl)-6-(5-methyl-4H-1,2,4-tria...)
Show SMILES Cc1nnc([nH]1)-c1cc2N(CCc2c(c1)-c1cccc(c1)C#N)C(=O)[C@@H]1CCCN1C#N
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445202
PNG
((S)-1-cyano-N-(4-(6-cyano-3-(2-methoxyethoxy)pyrid...)
Show SMILES COCCOc1ccc(nc1-c1csc(n1)N(C)C(=O)[C@@H]1CCCN1C#N)C#N
Show InChI InChI=1S/C19H20N6O3S/c1-24(18(26)15-4-3-7-25(15)12-21)19-23-14(11-29-19)17-16(28-9-8-27-2)6-5-13(10-20)22-17/h5-6,11,15H,3-4,7-9H2,1-2H3/t15-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445208
PNG
((S)-1-cyano-N-(4-(6-cyclopropylpyridin-2-yl)thiazo...)
Show SMILES CN(C(=O)[C@@H]1CCCN1C#N)c1nc(cs1)-c1cccc(n1)C1CC1
Show InChI InChI=1S/C18H19N5OS/c1-22(17(24)16-6-3-9-23(16)11-19)18-21-15(10-25-18)14-5-2-4-13(20-14)12-7-8-12/h2,4-5,10,12,16H,3,6-9H2,1H3/t16-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445151
PNG
((S)-2-(4-(5-(Trifluoromethyl)-1H-pyrazol-4-yl)-2,3...)
Show SMILES FC(F)(F)c1[nH]ncc1-c1nccc2N(CCc12)C(=O)[C@@H]1CCCN1C#N
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445082
PNG
((S)-2-(4-(5-Methyl-1H-pyrazol-4-yl)indoline-1-carb...)
Show SMILES Cc1[nH]ncc1-c1cccc2N(CCc12)C(=O)[C@@H]1CCCN1C#N
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445091
PNG
((S)-4,4-difluoro-2-(4-(5-methyl-1H-pyrazol-4-yl)in...)
Show SMILES Cc1[nH]ncc1-c1cccc2N(CCc12)C(=O)[C@@H]1CC(F)(F)CN1C#N
Show InChI InChI=1S/C18H17F2N5O/c1-11-14(8-22-23-11)12-3-2-4-15-13(12)5-6-25(15)17(26)16-7-18(19,20)9-24(16)10-21/h2-4,8,16H,5-7,9H2,1H3,(H,22,23)/t16-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445107
PNG
((S)-1-Cyano-N-(4-(2-methoxyphenyl)thiazol-2-yl)-N-...)
Show SMILES COc1ccccc1-c1csc(n1)N(C)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C17H18N4O2S/c1-20(16(22)14-7-5-9-21(14)11-18)17-19-13(10-24-17)12-6-3-4-8-15(12)23-2/h3-4,6,8,10,14H,5,7,9H2,1-2H3/t14-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445108
PNG
((S)-1-cyano-N-(4-(3- methoxyphenyl)thiazol-2- yl)-...)
Show SMILES COc1cccc(c1)-c1csc(n1)N(C)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C17H18N4O2S/c1-20(16(22)15-7-4-8-21(15)11-18)17-19-14(10-24-17)12-5-3-6-13(9-12)23-2/h3,5-6,9-10,15H,4,7-8H2,1-2H3/t15-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445174
PNG
((S)-1-Cyano-N-(4-(6-cyano-5-methylpyridin-2-yl)thi...)
Show SMILES CN(C(=O)[C@@H]1CCCN1C#N)c1nc(cs1)-c1ccc(C)c(n1)C#N
Show InChI InChI=1S/C17H16N6OS/c1-11-5-6-12(20-13(11)8-18)14-9-25-17(21-14)22(2)16(24)15-4-3-7-23(15)10-19/h5-6,9,15H,3-4,7H2,1-2H3/t15-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445156
PNG
((S)-1-Cyano-N-(4-(5-cyanopyridin-3-yl) thiazol-2-y...)
Show SMILES CN(C(=O)[C@@H]1CCCN1C(=O)OC(C)(C)C)c1nc(cs1)-c1cncc(Br)c1
Show InChI InChI=1S/C19H23BrN4O3S/c1-19(2,3)27-18(26)24-7-5-6-15(24)16(25)23(4)17-22-14(11-28-17)12-8-13(20)10-21-9-12/h8-11,15H,5-7H2,1-4H3/t15-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445167
PNG
((S)-N-(4-(3-chloro-4- fluorophenyl)thiazol-2-yl)-1...)
Show SMILES CN(C(=O)[C@@H]1CCCN1C#N)c1nc(cs1)-c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C16H14ClFN4OS/c1-21(15(23)14-3-2-6-22(14)9-19)16-20-13(8-24-16)10-4-5-12(18)11(17)7-10/h4-5,7-8,14H,2-3,6H2,1H3/t14-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445197
PNG
((S)-1-cyano-N-methyl-N-(4-(3-(N-methylmethylsulfon...)
Show SMILES CN(C(=O)[C@@H]1CCCN1C(=O)OC(C)(C)C)c1nc(cs1)-c1cccc(c1)N(C)S(C)(=O)=O
Show InChI InChI=1S/C22H30N4O5S2/c1-22(2,3)31-21(28)26-12-8-11-18(26)19(27)24(4)20-23-17(14-32-20)15-9-7-10-16(13-15)25(5)33(6,29)30/h7,9-10,13-14,18H,8,11-12H2,1-6H3/t18-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445200
PNG
((S)-1-cyano-N-(4-(6-cyano-5-ethoxypyridin-2-yl)thi...)
Show SMILES CCOc1ccc(nc1C#N)-c1csc(n1)N(C)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C18H18N6O2S/c1-3-26-16-7-6-12(21-13(16)9-19)14-10-27-18(22-14)23(2)17(25)15-5-4-8-24(15)11-20/h6-7,10,15H,3-5,8H2,1-2H3/t15-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445204
PNG
((S)-1-cyano-N-(4-(6-cyanopyridin-2-yl)-5-ethylthia...)
Show SMILES CCc1sc(nc1-c1cccc(n1)C#N)N(C)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C18H18N6OS/c1-3-15-16(13-7-4-6-12(10-19)21-13)22-18(26-15)23(2)17(25)14-8-5-9-24(14)11-20/h4,6-7,14H,3,5,8-9H2,1-2H3/t14-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445206
PNG
((S)-1-cyano-N-(4-(3-(methoxymethyl)phenyl)thiazol-...)
Show SMILES COCc1cccc(c1)-c1csc(n1)N(C)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C18H20N4O2S/c1-21(17(23)16-7-4-8-22(16)12-19)18-20-15(11-25-18)14-6-3-5-13(9-14)10-24-2/h3,5-6,9,11,16H,4,7-8,10H2,1-2H3/t16-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445098
PNG
((S)-2-(4-(3-cyclopropyl-1H- pyrazol-4-yl)indoline-...)
Show SMILES O=C([C@@H]1CCCN1C#N)N1CCc2c1cccc2-c1c[nH]nc1C1CC1
Show InChI InChI=1S/C20H21N5O/c21-12-24-9-2-5-18(24)20(26)25-10-8-15-14(3-1-4-17(15)25)16-11-22-23-19(16)13-6-7-13/h1,3-4,11,13,18H,2,5-10H2,(H,22,23)/t18-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445135
PNG
(4-(1-(Cyano-L-prolyl)indolin-4-yl)-1H-pyrazole-5-c...)
Show SMILES CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)N1CCc2c1cccc2-c1cn[nH]c1C#N
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445109
PNG
((S)-1-cyano-N-methyl-N-(4- (pyridin-2-yl)thiazol-2...)
Show SMILES CN(C(=O)[C@@H]1CCCN1C#N)c1nc(cs1)-c1ccccn1
Show InChI InChI=1S/C15H15N5OS/c1-19(14(21)13-6-4-8-20(13)10-16)15-18-12(9-22-15)11-5-2-3-7-17-11/h2-3,5,7,9,13H,4,6,8H2,1H3/t13-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445127
PNG
((S)-1-cyano-N-methyl-N- (5-phenylisoxazol-3-yl)- p...)
Show SMILES CN(C(=O)[C@@H]1CCCN1C#N)c1cc(on1)-c1ccccc1
Show InChI InChI=1S/C16H16N4O2/c1-19(16(21)13-8-5-9-20(13)11-17)15-10-14(22-18-15)12-6-3-2-4-7-12/h2-4,6-7,10,13H,5,8-9H2,1H3/t13-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445128
PNG
((S)-N-(3-(4-chlorophenyl)- isoxazol-5-yl)-1-cyano-...)
Show SMILES CN(C(=O)[C@@H]1CCCN1C#N)c1cc(no1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C16H15ClN4O2/c1-20(16(22)14-3-2-8-21(14)10-18)15-9-13(19-23-15)11-4-6-12(17)7-5-11/h4-7,9,14H,2-3,8H2,1H3/t14-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445147
PNG
((S)-2-(4-Phenyl-6-(4H-1,2,4-triazol-3-yl)indoline-...)
Show SMILES CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)N1CCc2c1cc(cc2-c1ccccc1)-c1nnc[nH]1
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MISSION THERAPEUTICS LIMITED

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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445153
PNG
(1-(cyano-L-prolyl)-4- (3,4-dichlorophenyl)- N-meth...)
Show SMILES CNC(=O)c1cc2N(CCc2c(c1)-c1ccc(Cl)c(Cl)c1)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C22H20Cl2N4O2/c1-26-21(29)14-9-16(13-4-5-17(23)18(24)10-13)15-6-8-28(20(15)11-14)22(30)19-3-2-7-27(19)12-25/h4-5,9-11,19H,2-3,6-8H2,1H3,(H,26,29)/t19-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445183
PNG
((S)-1-Cyano-N-(5-(3-cyanophenyl)isoxazol-3-yl)-N-m...)
Show SMILES CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)Nc1cc(on1)-c1cccc(Br)c1
Show InChI InChI=1S/C19H22BrN3O4/c1-19(2,3)26-18(25)23-9-5-8-14(23)17(24)21-16-11-15(27-22-16)12-6-4-7-13(20)10-12/h4,6-7,10-11,14H,5,8-9H2,1-3H3,(H,21,22,24)/t14-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445158
PNG
((S)-2-(5-(3-(trifluoro- methyl)-1H-pyrazol-4- yl)i...)
Show SMILES FC(F)(F)c1n[nH]cc1-c1ccc2CN(Cc2c1)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C18H16F3N5O/c19-18(20,21)16-14(7-23-24-16)11-3-4-12-8-26(9-13(12)6-11)17(27)15-2-1-5-25(15)10-22/h3-4,6-7,15H,1-2,5,8-9H2,(H,23,24)/t15-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445190
PNG
((S)-2-(5-(3-methyl-1H- indazol-6-yl)isoindoline- 2...)
Show SMILES Cc1n[nH]c2cc(ccc12)-c1ccc2CN(Cc2c1)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C22H21N5O/c1-14-19-7-6-16(10-20(19)25-24-14)15-4-5-17-11-27(12-18(17)9-15)22(28)21-3-2-8-26(21)13-23/h4-7,9-10,21H,2-3,8,11-12H2,1H3,(H,24,25)/t21-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445193
PNG
((S)-2-(5-(2-cyanophenyl)- isoindoline-2-carbonyl)-...)
Show SMILES O=C([C@@H]1CCCN1C#N)N1Cc2ccc(cc2C1)-c1ccccc1C#N
Show InChI InChI=1S/C21H18N4O/c22-11-16-4-1-2-5-19(16)15-7-8-17-12-25(13-18(17)10-15)21(26)20-6-3-9-24(20)14-23/h1-2,4-5,7-8,10,20H,3,6,9,12-13H2/t20-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445057
PNG
((S)-2-(4-isopropoxyindoline- 1-carbonyl)pyrrolidin...)
Show SMILES CC(C)Oc1cccc2N(CCc12)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C17H21N3O2/c1-12(2)22-16-7-3-5-14-13(16)8-10-20(14)17(21)15-6-4-9-19(15)11-18/h3,5,7,12,15H,4,6,8-10H2,1-2H3/t15-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445087
PNG
((S)-2-(4-(1H-pyrazol- 3-yl)indoline-1- carbonyl)py...)
Show SMILES O=C([C@@H]1CCCN1C#N)N1CCc2c1cccc2-c1cc[nH]n1
Show InChI InChI=1S/C17H17N5O/c18-11-21-9-2-5-16(21)17(23)22-10-7-13-12(3-1-4-15(13)22)14-6-8-19-20-14/h1,3-4,6,8,16H,2,5,7,9-10H2,(H,19,20)/t16-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445101
PNG
((S)-2-(4-(5-methylisoxazol-4- yl)indoline-1-carbon...)
Show SMILES Cc1oncc1-c1cccc2N(CCc12)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C18H18N4O2/c1-12-15(10-20-24-12)13-4-2-5-16-14(13)7-9-22(16)18(23)17-6-3-8-21(17)11-19/h2,4-5,10,17H,3,6-9H2,1H3/t17-/m0/s1
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445119
PNG
((S)-N-(5-benzylthiazol-2-yl)-1-cyano-N-methylpyrro...)
Show SMILES CN(C(=O)[C@@H]1CCCN1C#N)c1ncc(Cc2ccccc2)s1
Show InChI InChI=1S/C17H18N4OS/c1-20(16(22)15-8-5-9-21(15)12-18)17-19-11-14(23-17)10-13-6-3-2-4-7-13/h2-4,6-7,11,15H,5,8-10H2,1H3/t15-/m0/s1
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445157
PNG
((S)-2-(4-(3- chlorophenyl)indoline-1- carbonyl)pyr...)
Show SMILES Clc1cccc(c1)-c1cccc2N(CCc12)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C20H18ClN3O/c21-15-5-1-4-14(12-15)16-6-2-7-18-17(16)9-11-24(18)20(25)19-8-3-10-23(19)13-22/h1-2,4-7,12,19H,3,8-11H2/t19-/m0/s1
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445154
PNG
(4-(benzo[d][1,3]dioxol- 5-yl)-1-(cyano-L-prolyl)- ...)
Show SMILES CNC(=O)c1cc2N(CCc2c(c1)-c1ccc2OCOc2c1)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C23H22N4O4/c1-25-22(28)15-9-17(14-4-5-20-21(11-14)31-13-30-20)16-6-8-27(19(16)10-15)23(29)18-3-2-7-26(18)12-24/h4-5,9-11,18H,2-3,6-8,13H2,1H3,(H,25,28)/t18-/m0/s1
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445139
PNG
((S)-1-cyano-N-(4- (4-cyanopyridin-2- yl)thiazol-2-...)
Show SMILES CN(C(=O)[C@@H]1CCCN1C#N)c1nc(cs1)-c1cc(ccn1)C#N
Show InChI InChI=1S/C16H14N6OS/c1-21(15(23)14-3-2-6-22(14)10-18)16-20-13(9-24-16)12-7-11(8-17)4-5-19-12/h4-5,7,9,14H,2-3,6H2,1H3/t14-/m0/s1
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445144
PNG
(1-(Cyano-L-prolyl)-N-methyl-4-(quinolin-6-yl)indol...)
Show SMILES CNC(=O)c1cc2N(CCc2c(c1)-c1ccc2ncccc2c1)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C25H23N5O2/c1-27-24(31)18-13-20(16-6-7-21-17(12-16)4-2-9-28-21)19-8-11-30(23(19)14-18)25(32)22-5-3-10-29(22)15-26/h2,4,6-7,9,12-14,22H,3,5,8,10-11H2,1H3,(H,27,31)/t22-/m0/s1
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445083
PNG
((S)-2-(4-(4- cyanophenyl)indoline- 1-carbonyl)pyrr...)
Show SMILES O=C([C@@H]1CCCN1C#N)N1CCc2c1cccc2-c1ccc(cc1)C#N
Show InChI InChI=1S/C21H18N4O/c22-13-15-6-8-16(9-7-15)17-3-1-4-19-18(17)10-12-25(19)21(26)20-5-2-11-24(20)14-23/h1,3-4,6-9,20H,2,5,10-12H2/t20-/m0/s1
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MISSION THERAPEUTICS LIMITED

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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445140
PNG
((S)-1-cyano-N-(4- (6-methoxypyridin- 2-yl)thiazol-...)
Show SMILES COc1cccc(n1)-c1csc(n1)N(C)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C16H17N5O2S/c1-20(15(22)13-6-4-8-21(13)10-17)16-19-12(9-24-16)11-5-3-7-14(18-11)23-2/h3,5,7,9,13H,4,6,8H2,1-2H3/t13-/m0/s1
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MISSION THERAPEUTICS LIMITED

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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445141
PNG
(1-(Cyano-L-prolyl)-4-phenylindoline-6-carboxamide ...)
Show SMILES COC(=O)c1cc2N(CCc2c(Br)c1)C(=O)[C@@H]1CCCN1C(=O)OC(C)(C)C
Show InChI InChI=1S/C20H25BrN2O5/c1-20(2,3)28-19(26)23-8-5-6-15(23)17(24)22-9-7-13-14(21)10-12(11-16(13)22)18(25)27-4/h10-11,15H,5-9H2,1-4H3/t15-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445143
PNG
(1-(Cyano-L-prolyl)-4-(3-ethylphenyl)-N-methylindol...)
Show SMILES CCc1cccc(c1)-c1cc(cc2N(CCc12)C(=O)[C@@H]1CCCN1C#N)C(=O)NC
Show InChI InChI=1S/C24H26N4O2/c1-3-16-6-4-7-17(12-16)20-13-18(23(29)26-2)14-22-19(20)9-11-28(22)24(30)21-8-5-10-27(21)15-25/h4,6-7,12-14,21H,3,5,8-11H2,1-2H3,(H,26,29)/t21-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445144
PNG
(1-(Cyano-L-prolyl)-N-methyl-4-(quinolin-6-yl)indol...)
Show SMILES CNC(=O)c1cc2N(CCc2c(c1)-c1ccc2ncccc2c1)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C25H23N5O2/c1-27-24(31)18-13-20(16-6-7-21-17(12-16)4-2-9-28-21)19-8-11-30(23(19)14-18)25(32)22-5-3-10-29(22)15-26/h2,4,6-7,9,12-14,22H,3,5,8,10-11H2,1H3,(H,27,31)/t22-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445181
PNG
(4-(4-chlorophenyl)- 1-(cyano-L-prolyl)- N-methylin...)
Show SMILES CNC(=O)c1cc2N(CCc2c(c1)-c1ccc(Cl)cc1)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C22H21ClN4O2/c1-25-21(28)15-11-18(14-4-6-16(23)7-5-14)17-8-10-27(20(17)12-15)22(29)19-3-2-9-26(19)13-24/h4-7,11-12,19H,2-3,8-10H2,1H3,(H,25,28)/t19-/m0/s1
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MISSION THERAPEUTICS LIMITED

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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445157
PNG
((S)-2-(4-(3- chlorophenyl)indoline-1- carbonyl)pyr...)
Show SMILES Clc1cccc(c1)-c1cccc2N(CCc12)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C20H18ClN3O/c21-15-5-1-4-14(12-15)16-6-2-7-18-17(16)9-11-24(18)20(25)19-8-3-10-23(19)13-22/h1-2,4-7,12,19H,3,8-11H2/t19-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445063
PNG
((S)-2-(4-phenoxyindoline-1- carbonyl)pyrrolidine-1...)
Show SMILES O=C([C@@H]1CCCN1C#N)N1CCc2c1cccc2Oc1ccccc1
Show InChI InChI=1S/C20H19N3O2/c21-14-22-12-5-9-18(22)20(24)23-13-11-16-17(23)8-4-10-19(16)25-15-6-2-1-3-7-15/h1-4,6-8,10,18H,5,9,11-13H2/t18-/m0/s1
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445073
PNG
(3-(1-(cyano-L-prolyl)indolin-4- yl)-N-methylbenzam...)
Show SMILES CNC(=O)c1cccc(c1)-c1cccc2N(CCc12)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C22H22N4O2/c1-24-21(27)16-6-2-5-15(13-16)17-7-3-8-19-18(17)10-12-26(19)22(28)20-9-4-11-25(20)14-23/h2-3,5-8,13,20H,4,9-12H2,1H3,(H,24,27)/t20-/m0/s1
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445094
PNG
((S)-2-(5-phenylisoindoline- 2-carbonyl)pyrrolidine...)
Show SMILES O=C([C@@H]1CCCN1C#N)N1Cc2ccc(cc2C1)-c1ccccc1
Show InChI InChI=1S/C20H19N3O/c21-14-22-10-4-7-19(22)20(24)23-12-17-9-8-16(11-18(17)13-23)15-5-2-1-3-6-15/h1-3,5-6,8-9,11,19H,4,7,10,12-13H2/t19-/m0/s1
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445104
PNG
((S)-2-(6-Phenylindoline-1-carbonyl)pyrrolidine-1-c...)
Show SMILES O=C([C@@H]1CCCN1C#N)N1CCc2ccc(cc12)-c1ccccc1
Show InChI InChI=1S/C20H19N3O/c21-14-22-11-4-7-18(22)20(24)23-12-10-16-8-9-17(13-19(16)23)15-5-2-1-3-6-15/h1-3,5-6,8-9,13,18H,4,7,10-12H2/t18-/m0/s1
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445121
PNG
((S)-N-(4-(tert- butyl)thiazol-2-yl)-1- cyano-N- me...)
Show SMILES CN(C(=O)[C@@H]1CCCN1C#N)c1nc(cs1)C(C)(C)C
Show InChI InChI=1S/C14H20N4OS/c1-14(2,3)11-8-20-13(16-11)17(4)12(19)10-6-5-7-18(10)9-15/h8,10H,5-7H2,1-4H3/t10-/m0/s1
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445084
PNG
((S)-2-(4-(3- cyanophenyl)indoline- 1-carbonyl)pyrr...)
Show SMILES O=C([C@@H]1CCCN1C#N)N1CCc2c1cccc2-c1cccc(c1)C#N
Show InChI InChI=1S/C21H18N4O/c22-13-15-4-1-5-16(12-15)17-6-2-7-19-18(17)9-11-25(19)21(26)20-8-3-10-24(20)14-23/h1-2,4-7,12,20H,3,8-11H2/t20-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445094
PNG
((S)-2-(5-phenylisoindoline- 2-carbonyl)pyrrolidine...)
Show SMILES O=C([C@@H]1CCCN1C#N)N1Cc2ccc(cc2C1)-c1ccccc1
Show InChI InChI=1S/C20H19N3O/c21-14-22-10-4-7-19(22)20(24)23-12-17-9-8-16(11-18(17)13-23)15-5-2-1-3-6-15/h1-3,5-6,8-9,11,19H,4,7,10,12-13H2/t19-/m0/s1
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445115
PNG
((S)-1-cyano-N-methyl-N-(4-phenylthiazol-2-yl)pyrro...)
Show SMILES CN(C(=O)[C@@H]1CCCN1C#N)c1nc(cs1)-c1ccccc1
Show InChI InChI=1S/C16H16N4OS/c1-19(15(21)14-8-5-9-20(14)11-17)16-18-13(10-22-16)12-6-3-2-4-7-12/h2-4,6-7,10,14H,5,8-9H2,1H3/t14-/m0/s1
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445126
PNG
((S)-1-cyano-N-(3-(3- methoxyphenyl)isoxazol- 5-yl)...)
Show SMILES COc1cccc(c1)-c1cc(on1)N(C)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C17H18N4O3/c1-20(17(22)15-7-4-8-21(15)11-18)16-10-14(19-24-16)12-5-3-6-13(9-12)23-2/h3,5-6,9-10,15H,4,7-8H2,1-2H3/t15-/m0/s1
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445165
PNG
((S)-2-(4-(1H-pyrazolo[3,4- b]pyridin-3-yl)indoline...)
Show SMILES O=C([C@@H]1CCCN1C#N)N1CCc2c1cccc2-c1n[nH]c2ncccc12
Show InChI InChI=1S/C20H18N6O/c21-12-25-10-3-7-17(25)20(27)26-11-8-13-14(4-1-6-16(13)26)18-15-5-2-9-22-19(15)24-23-18/h1-2,4-6,9,17H,3,7-8,10-11H2,(H,22,23,24)/t17-/m0/s1
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445147
PNG
((S)-2-(4-Phenyl-6-(4H-1,2,4-triazol-3-yl)indoline-...)
Show SMILES CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)N1CCc2c1cc(cc2-c1ccccc1)-c1nnc[nH]1
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445152
PNG
(4-(2-chlorophenyl)-1- (cyano-L-prolyl)-N- methylin...)
Show SMILES CNC(=O)c1cc2N(CCc2c(c1)-c1ccccc1Cl)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C22H21ClN4O2/c1-25-21(28)14-11-17(15-5-2-3-6-18(15)23)16-8-10-27(20(16)12-14)22(29)19-7-4-9-26(19)13-24/h2-3,5-6,11-12,19H,4,7-10H2,1H3,(H,25,28)/t19-/m0/s1
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445075
PNG
((2S,4S)-4-methoxy-2-(4-phenylindoline-1-carbonyl)p...)
Show SMILES CO[C@H]1C[C@H](N(C1)C#N)C(=O)N1CCc2c1cccc2-c1ccccc1
Show InChI InChI=1S/C21H21N3O2/c1-26-16-12-20(23(13-16)14-22)21(25)24-11-10-18-17(8-5-9-19(18)24)15-6-3-2-4-7-15/h2-9,16,20H,10-13H2,1H3/t16-,20-/m0/s1
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445076
PNG
((2S,4R)-4-methoxy-2-(4-phenylindoline-1-carbonyl)p...)
Show SMILES CO[C@@H]1C[C@H](N(C1)C#N)C(=O)N1CCc2c1cccc2-c1ccccc1
Show InChI InChI=1S/C21H21N3O2/c1-26-16-12-20(23(13-16)14-22)21(25)24-11-10-18-17(8-5-9-19(18)24)15-6-3-2-4-7-15/h2-9,16,20H,10-13H2,1H3/t16-,20+/m1/s1
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445117
PNG
((S)-1-cyano-N-(4-isopropyl- thiazol-2-yl)-N-methyl...)
Show SMILES CC(C)c1csc(n1)N(C)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C13H18N4OS/c1-9(2)10-7-19-13(15-10)16(3)12(18)11-5-4-6-17(11)8-14/h7,9,11H,4-6H2,1-3H3/t11-/m0/s1
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445142
PNG
(1-(Cyano-L-prolyl)-N-ethyl-4-phenylindoline-6-carb...)
Show SMILES CCNC(=O)c1cc2N(CCc2c(c1)-c1ccccc1)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C23H24N4O2/c1-2-25-22(28)17-13-19(16-7-4-3-5-8-16)18-10-12-27(21(18)14-17)23(29)20-9-6-11-26(20)15-24/h3-5,7-8,13-14,20H,2,6,9-12H2,1H3,(H,25,28)/t20-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445143
PNG
(1-(Cyano-L-prolyl)-4-(3-ethylphenyl)-N-methylindol...)
Show SMILES CCc1cccc(c1)-c1cc(cc2N(CCc12)C(=O)[C@@H]1CCCN1C#N)C(=O)NC
Show InChI InChI=1S/C24H26N4O2/c1-3-16-6-4-7-17(12-16)20-13-18(23(29)26-2)14-22-19(20)9-11-28(22)24(30)21-8-5-10-27(21)15-25/h4,6-7,12-14,21H,3,5,8-11H2,1-2H3,(H,26,29)/t21-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445168
PNG
((S)-1-cyano-N-methyl-N-(4- (3-(trifluoromethyl)phe...)
Show SMILES CN(C(=O)[C@@H]1CCCN1C#N)c1nc(cs1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C17H15F3N4OS/c1-23(15(25)14-6-3-7-24(14)10-21)16-22-13(9-26-16)11-4-2-5-12(8-11)17(18,19)20/h2,4-5,8-9,14H,3,6-7H2,1H3/t14-/m0/s1
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445111
PNG
((S)-1-cyano-N-methyl-N-(4- (pyridin-4-yl)thiazol-2...)
Show SMILES CN(C(=O)[C@@H]1CCCN1C#N)c1nc(cs1)-c1ccncc1
Show InChI InChI=1S/C15H15N5OS/c1-19(14(21)13-3-2-8-20(13)10-16)15-18-12(9-22-15)11-4-6-17-7-5-11/h4-7,9,13H,2-3,8H2,1H3/t13-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445129
PNG
((S)-N-(4-(4-acetamidophenyl)thiazol-2-yl)-1-cyano-...)
Show SMILES CN(C(=O)[C@@H]1CCCN1C(=O)OC(C)(C)C)c1nc(cs1)-c1ccc(NC(C)=O)cc1
Show InChI InChI=1S/C22H28N4O4S/c1-14(27)23-16-10-8-15(9-11-16)17-13-31-20(24-17)25(5)19(28)18-7-6-12-26(18)21(29)30-22(2,3)4/h8-11,13,18H,6-7,12H2,1-5H3,(H,23,27)/t18-/m0/s1
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445130
PNG
((S)-N-(4-(3- acetamidophenyl)thiazol- 2-yl)-1-cyan...)
Show SMILES CN(C(=O)[C@@H]1CCCN1C#N)c1nc(cs1)-c1cccc(NC(C)=O)c1
Show InChI InChI=1S/C18H19N5O2S/c1-12(24)20-14-6-3-5-13(9-14)15-10-26-18(21-15)22(2)17(25)16-7-4-8-23(16)11-19/h3,5-6,9-10,16H,4,7-8H2,1-2H3,(H,20,24)/t16-/m0/s1
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445145
PNG
(1-(Cyano-L-prolyl)-N-methyl-4-(1H-pyrrolo[2,3-b]py...)
Show SMILES CNC(=O)c1cc2N(CCc2c(c1)-c1c[nH]c2ncccc12)C(=O)[C@@H]1CCCN1C#N
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445180
PNG
(4-(4-chlorophenyl)- 1-(cyano-L-prolyl)- N-methylin...)
Show SMILES CNC(=O)c1cc2N(CCc2c(c1)-c1ccc(Cl)cc1)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C22H21ClN4O2/c1-25-21(28)15-11-18(14-4-6-16(23)7-5-14)17-8-10-27(20(17)12-15)22(29)19-3-2-9-26(19)13-24/h4-7,11-12,19H,2-3,8-10H2,1H3,(H,25,28)/t19-/m0/s1
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445184
PNG
((S)-1-Cyano-N-(5-(3-methoxyphenyl)isoxazol-3-yl)-N...)
Show SMILES COc1cccc(c1)-c1cc(no1)N(C)C(=O)[C@@H]1CCCN1C(=O)OC(C)(C)C
Show InChI InChI=1S/C21H27N3O5/c1-21(2,3)28-20(26)24-11-7-10-16(24)19(25)23(4)18-13-17(29-22-18)14-8-6-9-15(12-14)27-5/h6,8-9,12-13,16H,7,10-11H2,1-5H3/t16-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445189
PNG
((S)-2-(5-(3-(trifluoro- methoxy)phenyl) isoindolin...)
Show SMILES FC(F)(F)Oc1cccc(c1)-c1ccc2CN(Cc2c1)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C21H18F3N3O2/c22-21(23,24)29-18-4-1-3-14(10-18)15-6-7-16-11-27(12-17(16)9-15)20(28)19-5-2-8-26(19)13-25/h1,3-4,6-7,9-10,19H,2,5,8,11-12H2/t19-/m0/s1
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445192
PNG
((S)-2-(5-(4-(methyl- sulfonyl)phenyl)isoindoline- ...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1ccc2CN(Cc2c1)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C21H21N3O3S/c1-28(26,27)19-8-6-15(7-9-19)16-4-5-17-12-24(13-18(17)11-16)21(25)20-3-2-10-23(20)14-22/h4-9,11,20H,2-3,10,12-13H2,1H3/t20-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445056
PNG
((S)-2-(4-Ethoxyindoline-1-carbonyl)pyrrolidine-1-c...)
Show SMILES CCOc1cccc2N(CCc12)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C16H19N3O2/c1-2-21-15-7-3-5-13-12(15)8-10-19(13)16(20)14-6-4-9-18(14)11-17/h3,5,7,14H,2,4,6,8-10H2,1H3/t14-/m0/s1
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445070
PNG
((S)-2-(4-(4- methoxyphenyl)indoline-1- carbonyl)py...)
Show SMILES COc1ccc(cc1)-c1cccc2N(CCc12)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C21H21N3O2/c1-26-16-9-7-15(8-10-16)17-4-2-5-19-18(17)11-13-24(19)21(25)20-6-3-12-23(20)14-22/h2,4-5,7-10,20H,3,6,11-13H2,1H3/t20-/m0/s1
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445074
PNG
((S)-2-(4-cyclopropylindoline-1- carbonyl)pyrrolidi...)
Show SMILES O=C([C@@H]1CCCN1C#N)N1CCc2c1cccc2C1CC1
Show InChI InChI=1S/C17H19N3O/c18-11-19-9-2-5-16(19)17(21)20-10-8-14-13(12-6-7-12)3-1-4-15(14)20/h1,3-4,12,16H,2,5-10H2/t16-/m0/s1
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445078
PNG
((S)-2-(5-phenylindoline- 1-carbonyl)pyrrolidine- 1...)
Show SMILES O=C([C@@H]1CCCN1C#N)N1CCc2cc(ccc12)-c1ccccc1
Show InChI InChI=1S/C20H19N3O/c21-14-22-11-4-7-19(22)20(24)23-12-10-17-13-16(8-9-18(17)23)15-5-2-1-3-6-15/h1-3,5-6,8-9,13,19H,4,7,10-12H2/t19-/m0/s1
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445084
PNG
((S)-2-(4-(3- cyanophenyl)indoline- 1-carbonyl)pyrr...)
Show SMILES O=C([C@@H]1CCCN1C#N)N1CCc2c1cccc2-c1cccc(c1)C#N
Show InChI InChI=1S/C21H18N4O/c22-13-15-4-1-5-16(12-15)17-6-2-7-19-18(17)9-11-25(19)21(26)20-8-3-10-24(20)14-23/h1-2,4-7,12,20H,3,8-11H2/t20-/m0/s1
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445105
PNG
((S)-2-(8-phenyl-3,4-dihydro- 2H-benzo[b][1,4]oxazi...)
Show SMILES O=C([C@@H]1CCCN1C#N)N1CCOc2c1cccc2-c1ccccc1
Show InChI InChI=1S/C20H19N3O2/c21-14-22-11-5-10-18(22)20(24)23-12-13-25-19-16(8-4-9-17(19)23)15-6-2-1-3-7-15/h1-4,6-9,18H,5,10-13H2/t18-/m0/s1
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445122
PNG
((S)-N-(4-(4- chlorophenyl)thiazol- 2-yl)-1-cyano-N...)
Show SMILES CN(C(=O)[C@@H]1CCCN1C#N)c1nc(cs1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C16H15ClN4OS/c1-20(15(22)14-3-2-8-21(14)10-18)16-19-13(9-23-16)11-4-6-12(17)7-5-11/h4-7,9,14H,2-3,8H2,1H3/t14-/m0/s1
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445133
PNG
((S)-2-(4-(3-Methylisoxazol-4-yl)indoline-1-carbony...)
Show SMILES CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)N1CCc2c1cccc2C#C[Si](C)(C)C
Show InChI InChI=1S/C23H32N2O3Si/c1-23(2,3)28-22(27)25-14-8-11-20(25)21(26)24-15-12-18-17(9-7-10-19(18)24)13-16-29(4,5)6/h7,9-10,20H,8,11-12,14-15H2,1-6H3/t20-/m0/s1
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445085
PNG
((S)-2-(4-(2- cyanophenyl)indoline- 1-carbonyl)pyrr...)
Show SMILES O=C([C@@H]1CCCN1C#N)N1CCc2c1cccc2-c1ccccc1C#N
Show InChI InChI=1S/C21H18N4O/c22-13-15-5-1-2-6-16(15)17-7-3-8-19-18(17)10-12-25(19)21(26)20-9-4-11-24(20)14-23/h1-3,5-8,20H,4,9-12H2/t20-/m0/s1
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445120
PNG
((S)-1-cyano-N-methyl- N-(5-phenylthiazol-2- yl)pyr...)
Show SMILES CN(C(=O)[C@@H]1CCCN1C#N)c1ncc(s1)-c1ccccc1
Show InChI InChI=1S/C16H16N4OS/c1-19(15(21)13-8-5-9-20(13)11-17)16-18-10-14(22-16)12-6-3-2-4-7-12/h2-4,6-7,10,13H,5,8-9H2,1H3/t13-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445125
PNG
((S)-N-(3-(3-Chlorophenyl)isoxazol-5-yl)-1-cyano-N-...)
Show SMILES CN(C(=O)[C@@H]1CCCN1C#N)c1cc(no1)-c1cccc(Cl)c1
Show InChI InChI=1S/C16H15ClN4O2/c1-20(16(22)14-6-3-7-21(14)10-18)15-9-13(19-23-15)11-4-2-5-12(17)8-11/h2,4-5,8-9,14H,3,6-7H2,1H3/t14-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445182
PNG
((S)-N-(5-(3-Chlorophenyl)isoxazol-3-yl)-1-cyano-N-...)
Show SMILES CN(C(=O)[C@@H]1CCCN1C(=O)OC(C)(C)C)c1cc(on1)-c1cccc(Cl)c1
Show InChI InChI=1S/C20H24ClN3O4/c1-20(2,3)27-19(26)24-10-6-9-15(24)18(25)23(4)17-12-16(28-22-17)13-7-5-8-14(21)11-13/h5,7-8,11-12,15H,6,9-10H2,1-4H3/t15-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445191
PNG
((S)-2-(5-(1-methyl-1H- indazol-5-yl)isoindoline- 2...)
Show SMILES Cn1ncc2cc(ccc12)-c1ccc2CN(Cc2c1)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C22H21N5O/c1-25-20-7-6-16(9-18(20)11-24-25)15-4-5-17-12-27(13-19(17)10-15)22(28)21-3-2-8-26(21)14-23/h4-7,9-11,21H,2-3,8,12-13H2,1H3/t21-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445207
PNG
((S)-1-cyano-N-(5-cyano-4-phenylthiazol-2-yl)-N-met...)
Show SMILES CN(C(=O)[C@@H]1CCCN1C(=O)OC(C)(C)C)c1nc(c(s1)C#N)-c1ccccc1
Show InChI InChI=1S/C21H24N4O3S/c1-21(2,3)28-20(27)25-12-8-11-15(25)18(26)24(4)19-23-17(16(13-22)29-19)14-9-6-5-7-10-14/h5-7,9-10,15H,8,11-12H2,1-4H3/t15-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445153
PNG
(1-(cyano-L-prolyl)-4- (3,4-dichlorophenyl)- N-meth...)
Show SMILES CNC(=O)c1cc2N(CCc2c(c1)-c1ccc(Cl)c(Cl)c1)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C22H20Cl2N4O2/c1-26-21(29)14-9-16(13-4-5-17(23)18(24)10-13)15-6-8-28(20(15)11-14)22(30)19-3-2-7-27(19)12-25/h4-5,9-11,19H,2-3,6-8H2,1H3,(H,26,29)/t19-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445068
PNG
((S)-2-(5-(3,5-dimethylisoxazol- 4-yl)indoline-l- c...)
Show SMILES Cc1noc(C)c1-c1ccc2N(CCc2c1)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C19H20N4O2/c1-12-18(13(2)25-21-12)15-5-6-16-14(10-15)7-9-23(16)19(24)17-4-3-8-22(17)11-20/h5-6,10,17H,3-4,7-9H2,1-2H3/t17-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445071
PNG
((S)-2-(4-(2,6- dimethylphenyl)indoline-1- carbonyl...)
Show SMILES Cc1cccc(C)c1-c1cccc2N(CCc12)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C22H23N3O/c1-15-6-3-7-16(2)21(15)18-8-4-9-19-17(18)11-13-25(19)22(26)20-10-5-12-24(20)14-23/h3-4,6-9,20H,5,10-13H2,1-2H3/t20-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445085
PNG
((S)-2-(4-(2- cyanophenyl)indoline- 1-carbonyl)pyrr...)
Show SMILES O=C([C@@H]1CCCN1C#N)N1CCc2c1cccc2-c1ccccc1C#N
Show InChI InChI=1S/C21H18N4O/c22-13-15-5-1-2-6-16(15)17-7-3-8-19-18(17)10-12-25(19)21(26)20-9-4-11-24(20)14-23/h1-3,5-8,20H,4,9-12H2/t20-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445103
PNG
((S)-2-(4-(pyridin-3-yl)indoline- 1-carbonyl)pyrrol...)
Show SMILES O=C([C@@H]1CCCN1C#N)N1CCc2c1cccc2-c1cccnc1
Show InChI InChI=1S/C19H18N4O/c20-13-22-10-3-7-18(22)19(24)23-11-8-16-15(5-1-6-17(16)23)14-4-2-9-21-12-14/h1-2,4-6,9,12,18H,3,7-8,10-11H2/t18-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445111
PNG
((S)-1-cyano-N-methyl-N-(4- (pyridin-4-yl)thiazol-2...)
Show SMILES CN(C(=O)[C@@H]1CCCN1C#N)c1nc(cs1)-c1ccncc1
Show InChI InChI=1S/C15H15N5OS/c1-19(14(21)13-3-2-8-20(13)10-16)15-18-12(9-22-15)11-4-6-17-7-5-11/h4-7,9,13H,2-3,8H2,1H3/t13-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445123
PNG
((S)-N-(3-(2-chloro- phenyl)isoxazol- 5-yl)-1-cyano...)
Show SMILES CN(C(=O)[C@@H]1CCCN1C#N)c1cc(no1)-c1ccccc1Cl
Show InChI InChI=1S/C16H15ClN4O2/c1-20(16(22)14-7-4-8-21(14)10-18)15-9-13(19-23-15)11-5-2-3-6-12(11)17/h2-3,5-6,9,14H,4,7-8H2,1H3/t14-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445124
PNG
((2S,4S)-1-cyano-N-methyl-4- phenyl-N-(4-phenylthia...)
Show SMILES CN(C(=O)[C@@H]1C[C@H](CN1C#N)c1ccccc1)c1nc(cs1)-c1ccccc1
Show InChI InChI=1S/C22H20N4OS/c1-25(22-24-19(14-28-22)17-10-6-3-7-11-17)21(27)20-12-18(13-26(20)15-23)16-8-4-2-5-9-16/h2-11,14,18,20H,12-13H2,1H3/t18-,20+/m1/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445146
PNG
((S)-2-(6-(1H-Imidazol-2-yl)-4-phenylindoline-1-car...)
Show SMILES CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)N1CCc2c1cc(cc2-c1ccccc1)-c1ncc[nH]1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445154
PNG
(4-(benzo[d][1,3]dioxol- 5-yl)-1-(cyano-L-prolyl)- ...)
Show SMILES CNC(=O)c1cc2N(CCc2c(c1)-c1ccc2OCOc2c1)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C23H22N4O4/c1-25-22(28)15-9-17(14-4-5-20-21(11-14)31-13-30-20)16-6-8-27(19(16)10-15)23(29)18-3-2-7-26(18)12-24/h4-5,9-11,18H,2-3,6-8,13H2,1H3,(H,25,28)/t18-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445186
PNG
((S)-2-(5-(4-cyanophenyl)- isoindoline-2-carbonyl)-...)
Show SMILES O=C([C@@H]1CCCN1C#N)N1Cc2ccc(cc2C1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C21H18N4O/c22-11-15-3-5-16(6-4-15)17-7-8-18-12-25(13-19(18)10-17)21(26)20-2-1-9-24(20)14-23/h3-8,10,20H,1-2,9,12-13H2/t20-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445148
PNG
((S)-2-(6-(5-Methyl-4H-1,2,4-triazol-3-yl)-4-phenyl...)
Show SMILES Cc1nnc([nH]1)-c1cc2N(CCc2c(c1)-c1ccccc1)C(=O)[C@@H]1CCCN1C#N
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445069
PNG
((S)-2-(4-(3- methoxyphenyl)indoline-1- carbonyl)py...)
Show SMILES COc1cccc(c1)-c1cccc2N(CCc12)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C21H21N3O2/c1-26-16-6-2-5-15(13-16)17-7-3-8-19-18(17)10-12-24(19)21(25)20-9-4-11-23(20)14-22/h2-3,5-8,13,20H,4,9-12H2,1H3/t20-/m0/s1
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MISSION THERAPEUTICS LIMITED

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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445102
PNG
((S)-2-(4-(3,5-dimethylisoxazol- 4-yl)indoline-1-ca...)
Show SMILES Cc1noc(C)c1-c1cccc2N(CCc12)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C19H20N4O2/c1-12-18(13(2)25-21-12)15-5-3-6-16-14(15)8-10-23(16)19(24)17-7-4-9-22(17)11-20/h3,5-6,17H,4,7-10H2,1-2H3/t17-/m0/s1
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MISSION THERAPEUTICS LIMITED

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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445162
PNG
((S)-2-(4-(6-aminopyrazin- 2-yl)indoline-1- carbony...)
Show SMILES Nc1cncc(n1)-c1cccc2N(CCc12)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C18H18N6O/c19-11-23-7-2-5-16(23)18(25)24-8-6-13-12(3-1-4-15(13)24)14-9-21-10-17(20)22-14/h1,3-4,9-10,16H,2,5-8H2,(H2,20,22)/t16-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445146
PNG
((S)-2-(6-(1H-Imidazol-2-yl)-4-phenylindoline-1-car...)
Show SMILES CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)N1CCc2c1cc(cc2-c1ccccc1)-c1ncc[nH]1
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MISSION THERAPEUTICS LIMITED

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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445114
PNG
((S)-N-(4-(2-chlorophenyl)- thiazol-2-yl)-1-cyano-N...)
Show SMILES CN(C(=O)[C@@H]1CCCN1C#N)c1nc(cs1)-c1ccccc1Cl
Show InChI InChI=1S/C16H15ClN4OS/c1-20(15(22)14-7-4-8-21(14)10-18)16-19-13(9-23-16)11-5-2-3-6-12(11)17/h2-3,5-6,9,14H,4,7-8H2,1H3/t14-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445177
PNG
(1-(Cyano-L-prolyl)-N-methyl-4-(4-(trifluoromethyl)...)
Show SMILES CNC(=O)c1cc2N(CCc2c(c1)-c1ccc(cc1)C(F)(F)F)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C23H21F3N4O2/c1-28-21(31)15-11-18(14-4-6-16(7-5-14)23(24,25)26)17-8-10-30(20(17)12-15)22(32)19-3-2-9-29(19)13-27/h4-7,11-12,19H,2-3,8-10H2,1H3,(H,28,31)/t19-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445179
PNG
(1-(cyano-L-prolyl)-4- (4-cyanophenyl)-N- methylind...)
Show SMILES CNC(=O)c1cc2N(CCc2c(c1)-c1ccc(cc1)C#N)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C23H21N5O2/c1-26-22(29)17-11-19(16-6-4-15(13-24)5-7-16)18-8-10-28(21(18)12-17)23(30)20-3-2-9-27(20)14-25/h4-7,11-12,20H,2-3,8-10H2,1H3,(H,26,29)/t20-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445199
PNG
((S)-1-cyano-N-(4- (6-isopropoxypyridin- 2-yl)thiaz...)
Show SMILES CC(C)Oc1cccc(n1)-c1csc(n1)N(C)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C18H21N5O2S/c1-12(2)25-16-8-4-6-13(20-16)14-10-26-18(21-14)22(3)17(24)15-7-5-9-23(15)11-19/h4,6,8,10,12,15H,5,7,9H2,1-3H3/t15-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445067
PNG
((S)-2-(4-Phenylindoline-1-carbonyl)pyrrolidine-1-c...)
Show SMILES O=C([C@@H]1CCCN1C#N)N1CCc2c1cccc2-c1ccccc1
Show InChI InChI=1S/C20H19N3O/c21-14-22-12-5-10-19(22)20(24)23-13-11-17-16(8-4-9-18(17)23)15-6-2-1-3-7-15/h1-4,6-9,19H,5,10-13H2/t19-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445093
PNG
((S)-2-(4-phenylisoindoline- 2-carbonyl)pyrrolidine...)
Show SMILES O=C([C@@H]1CCCN1C#N)N1Cc2cccc(c2C1)-c1ccccc1
Show InChI InChI=1S/C20H19N3O/c21-14-22-11-5-10-19(22)20(24)23-12-16-8-4-9-17(18(16)13-23)15-6-2-1-3-7-15/h1-4,6-9,19H,5,10-13H2/t19-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445112
PNG
((2S)-1-cyano-N-methyl-N-(4- (tetrahydrofuran-3-yl)...)
Show SMILES CN(C(=O)[C@@H]1CCCN1C#N)c1nc(cs1)C1CCOC1
Show InChI InChI=1S/C14H18N4O2S/c1-17(13(19)12-3-2-5-18(12)9-15)14-16-11(8-21-14)10-4-6-20-7-10/h8,10,12H,2-7H2,1H3/t10?,12-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445131
PNG
(Ethyl 4-(1-(cyano-L-prolyl)indolin-4-yl)-1-(4-meth...)
Show SMILES CCOC(=O)c1c(cnn1Cc1ccc(OC)cc1)B1OC(C)(C)C(C)(C)O1
Show InChI InChI=1S/C20H27BN2O5/c1-7-26-18(24)17-16(21-27-19(2,3)20(4,5)28-21)12-22-23(17)13-14-8-10-15(25-6)11-9-14/h8-12H,7,13H2,1-6H3
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445134
PNG
((S)-2-(4-(1H-imidazol-1-yl)indoline-1-carbonyl)pyr...)
Show SMILES CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)N1CCc2c1cccc2Br
Show InChI InChI=1S/C18H23BrN2O3/c1-18(2,3)24-17(23)21-10-5-8-15(21)16(22)20-11-9-12-13(19)6-4-7-14(12)20/h4,6-7,15H,5,8-11H2,1-3H3/t15-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445141
PNG
(1-(Cyano-L-prolyl)-4-phenylindoline-6-carboxamide ...)
Show SMILES COC(=O)c1cc2N(CCc2c(Br)c1)C(=O)[C@@H]1CCCN1C(=O)OC(C)(C)C
Show InChI InChI=1S/C20H25BrN2O5/c1-20(2,3)28-19(26)23-8-5-6-15(23)17(24)22-9-7-13-14(21)10-12(11-16(13)22)18(25)27-4/h10-11,15H,5-9H2,1-4H3/t15-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445178
PNG
(1-(cyano-L-prolyl)-4- (3-cyanophenyl)-N- methylind...)
Show SMILES CNC(=O)c1cc2N(CCc2c(c1)-c1cccc(c1)C#N)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C23H21N5O2/c1-26-22(29)17-11-19(16-5-2-4-15(10-16)13-24)18-7-9-28(21(18)12-17)23(30)20-6-3-8-27(20)14-25/h2,4-5,10-12,20H,3,6-9H2,1H3,(H,26,29)/t20-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445195
PNG
((S)-2-(5-(3-cyano-2- fluorophenyl)isoindoline- 2-c...)
Show SMILES Fc1c(cccc1-c1ccc2CN(Cc2c1)C(=O)[C@@H]1CCCN1C#N)C#N
Show InChI InChI=1S/C21H17FN4O/c22-20-15(10-23)3-1-4-18(20)14-6-7-16-11-26(12-17(16)9-14)21(27)19-5-2-8-25(19)13-24/h1,3-4,6-7,9,19H,2,5,8,11-12H2/t19-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445196
PNG
((S)-1-cyano-N-methyl-N-(4-(3-(N-methylacetamido)ph...)
Show SMILES CN(C(=O)[C@@H]1CCCN1C(=O)OC(C)(C)C)c1nc(cs1)-c1cccc(c1)N(C)C(C)=O
Show InChI InChI=1S/C23H30N4O4S/c1-15(28)25(5)17-10-7-9-16(13-17)18-14-32-21(24-18)26(6)20(29)19-11-8-12-27(19)22(30)31-23(2,3)4/h7,9-10,13-14,19H,8,11-12H2,1-6H3/t19-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445065
PNG
((S)-2-(5-phenoxyindoline-1- carbonyl)pyrrolidine-1...)
Show SMILES O=C([C@@H]1CCCN1C#N)N1CCc2cc(Oc3ccccc3)ccc12
Show InChI InChI=1S/C20H19N3O2/c21-14-22-11-4-7-19(22)20(24)23-12-10-15-13-17(8-9-18(15)23)25-16-5-2-1-3-6-16/h1-3,5-6,8-9,13,19H,4,7,10-12H2/t19-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445066
PNG
((S)-1-cyano-N-ethyl-N-(4- phenylthiazol-2- yl)pyrr...)
Show SMILES CCN(C(=O)[C@@H]1CCCN1C#N)c1nc(cs1)-c1ccccc1
Show InChI InChI=1S/C17H18N4OS/c1-2-21(16(22)15-9-6-10-20(15)12-18)17-19-14(11-23-17)13-7-4-3-5-8-13/h3-5,7-8,11,15H,2,6,9-10H2,1H3/t15-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445072
PNG
((S)-2-(4-(2- methoxyphenyl)indoline-l- carbonyl)py...)
Show SMILES COc1ccccc1-c1cccc2N(CCc12)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C21H21N3O2/c1-26-20-10-3-2-6-17(20)15-7-4-8-18-16(15)11-13-24(18)21(25)19-9-5-12-23(19)14-22/h2-4,6-8,10,19H,5,9,11-13H2,1H3/t19-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445077
PNG
((S)-2-(5-(5-methylisoxazol- 4-yl)indoline-1- carbo...)
Show SMILES Cc1oncc1-c1ccc2N(CCc2c1)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C18H18N4O2/c1-12-15(10-20-24-12)13-4-5-16-14(9-13)6-8-22(16)18(23)17-3-2-7-21(17)11-19/h4-5,9-10,17H,2-3,6-8H2,1H3/t17-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445079
PNG
((S)-2-(5-(5-(trifluoromethyl)- 1H-pyrazol-4-yl)ind...)
Show SMILES FC(F)(F)c1[nH]ncc1-c1ccc2N(CCc2c1)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C18H16F3N5O/c19-18(20,21)16-13(9-23-24-16)11-3-4-14-12(8-11)5-7-26(14)17(27)15-2-1-6-25(15)10-22/h3-4,8-9,15H,1-2,5-7H2,(H,23,24)/t15-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445097
PNG
((S)-2-(4-(pyrimidin-4-yl)- indoline-1-carbonyl)pyr...)
Show SMILES O=C([C@@H]1CCCN1C#N)N1CCc2c1cccc2-c1ccncn1
Show InChI InChI=1S/C18H17N5O/c19-11-22-9-2-5-17(22)18(24)23-10-7-14-13(3-1-4-16(14)23)15-6-8-20-12-21-15/h1,3-4,6,8,12,17H,2,5,7,9-10H2/t17-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445110
PNG
((S)-1-cyano-N-methyl-N-(4- (pyridin-3-yl)thiazol-2...)
Show SMILES CN(C(=O)[C@@H]1CCCN1C#N)c1nc(cs1)-c1cccnc1
Show InChI InChI=1S/C15H15N5OS/c1-19(14(21)13-5-3-7-20(13)10-16)15-18-12(9-22-15)11-4-2-6-17-8-11/h2,4,6,8-9,13H,3,5,7H2,1H3/t13-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445125
PNG
((S)-N-(3-(3-Chlorophenyl)isoxazol-5-yl)-1-cyano-N-...)
Show SMILES CN(C(=O)[C@@H]1CCCN1C#N)c1cc(no1)-c1cccc(Cl)c1
Show InChI InChI=1S/C16H15ClN4O2/c1-20(16(22)14-6-3-7-21(14)10-18)15-9-13(19-23-15)11-4-2-5-12(17)8-11/h2,4-5,8-9,14H,3,6-7H2,1H3/t14-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445138
PNG
((S)-1-cyano-N-(4-(2- cyanopyridin-4- yl)thiazol-2-...)
Show SMILES CN(C(=O)[C@@H]1CCCN1C#N)c1nc(cs1)-c1ccnc(c1)C#N
Show InChI InChI=1S/C16H14N6OS/c1-21(15(23)14-3-2-6-22(14)10-18)16-20-13(9-24-16)11-4-5-19-12(7-11)8-17/h4-5,7,9,14H,2-3,6H2,1H3/t14-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445110
PNG
((S)-1-cyano-N-methyl-N-(4- (pyridin-3-yl)thiazol-2...)
Show SMILES CN(C(=O)[C@@H]1CCCN1C#N)c1nc(cs1)-c1cccnc1
Show InChI InChI=1S/C15H15N5OS/c1-19(14(21)13-5-3-7-20(13)10-16)15-18-12(9-22-15)11-4-2-6-17-8-11/h2,4,6,8-9,13H,3,5,7H2,1H3/t13-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445126
PNG
((S)-1-cyano-N-(3-(3- methoxyphenyl)isoxazol- 5-yl)...)
Show SMILES COc1cccc(c1)-c1cc(on1)N(C)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C17H18N4O3/c1-20(17(22)15-7-4-8-21(15)11-18)16-10-14(19-24-16)12-5-3-6-13(9-12)23-2/h3,5-6,9-10,15H,4,7-8H2,1-2H3/t15-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445118
PNG
((S)-1-cyano-N-methyl-N- (3-phenylisoxazol-5- yl)py...)
Show SMILES CN(C(=O)[C@@H]1CCCN1C#N)c1cc(no1)-c1ccccc1
Show InChI InChI=1S/C16H16N4O2/c1-19(16(21)14-8-5-9-20(14)11-17)15-10-13(18-22-15)12-6-3-2-4-7-12/h2-4,6-7,10,14H,5,8-9H2,1H3/t14-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445104
PNG
((S)-2-(6-Phenylindoline-1-carbonyl)pyrrolidine-1-c...)
Show SMILES O=C([C@@H]1CCCN1C#N)N1CCc2ccc(cc12)-c1ccccc1
Show InChI InChI=1S/C20H19N3O/c21-14-22-11-4-7-18(22)20(24)23-12-10-16-8-9-17(13-19(16)23)15-5-2-1-3-6-15/h1-3,5-6,8-9,13,18H,4,7,10-12H2/t18-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445123
PNG
((S)-N-(3-(2-chloro- phenyl)isoxazol- 5-yl)-1-cyano...)
Show SMILES CN(C(=O)[C@@H]1CCCN1C#N)c1cc(no1)-c1ccccc1Cl
Show InChI InChI=1S/C16H15ClN4O2/c1-20(16(22)14-7-4-8-21(14)10-18)15-9-13(19-23-15)11-5-2-3-6-12(11)17/h2-3,5-6,9,14H,4,7-8H2,1H3/t14-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445156
PNG
((S)-1-Cyano-N-(4-(5-cyanopyridin-3-yl) thiazol-2-y...)
Show SMILES CN(C(=O)[C@@H]1CCCN1C(=O)OC(C)(C)C)c1nc(cs1)-c1cncc(Br)c1
Show InChI InChI=1S/C19H23BrN4O3S/c1-19(2,3)27-18(26)24-7-5-6-15(24)16(25)23(4)17-22-14(11-28-17)12-8-13(20)10-21-9-12/h8-11,15H,5-7H2,1-4H3/t15-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445118
PNG
((S)-1-cyano-N-methyl-N- (3-phenylisoxazol-5- yl)py...)
Show SMILES CN(C(=O)[C@@H]1CCCN1C#N)c1cc(no1)-c1ccccc1
Show InChI InChI=1S/C16H16N4O2/c1-19(16(21)14-8-5-9-20(14)11-17)15-10-13(18-22-15)12-6-3-2-4-7-12/h2-4,6-7,10,14H,5,8-9H2,1H3/t14-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445096
PNG
((S)-2-(4-(pyridazin-4-yl)- indoline-1-carbonyl)pyr...)
Show SMILES O=C([C@@H]1CCCN1C#N)N1CCc2c1cccc2-c1ccnnc1
Show InChI InChI=1S/C18H17N5O/c19-12-22-9-2-5-17(22)18(24)23-10-7-15-14(3-1-4-16(15)23)13-6-8-20-21-11-13/h1,3-4,6,8,11,17H,2,5,7,9-10H2/t17-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445116
PNG
((S)-1-cyano-N-methyl-N- (1-phenyl-1H-pyrazol-3-yl)...)
Show SMILES CN(C(=O)[C@@H]1CCCN1C#N)c1ccn(n1)-c1ccccc1
Show InChI InChI=1S/C16H17N5O/c1-19(16(22)14-8-5-10-20(14)12-17)15-9-11-21(18-15)13-6-3-2-4-7-13/h2-4,6-7,9,11,14H,5,8,10H2,1H3/t14-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445120
PNG
((S)-1-cyano-N-methyl- N-(5-phenylthiazol-2- yl)pyr...)
Show SMILES CN(C(=O)[C@@H]1CCCN1C#N)c1ncc(s1)-c1ccccc1
Show InChI InChI=1S/C16H16N4OS/c1-19(15(21)13-8-5-9-20(13)11-17)16-18-10-14(22-16)12-6-3-2-4-7-12/h2-4,6-7,10,13H,5,8-9H2,1H3/t13-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445128
PNG
((S)-N-(3-(4-chlorophenyl)- isoxazol-5-yl)-1-cyano-...)
Show SMILES CN(C(=O)[C@@H]1CCCN1C#N)c1cc(no1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C16H15ClN4O2/c1-20(16(22)14-3-2-8-21(14)10-18)15-9-13(19-23-15)11-4-6-12(17)7-5-11/h4-7,9,14H,2-3,8H2,1H3/t14-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445136
PNG
((S)-2-(5-Phenyl-1,2,3,4-tetrahydroisoquinoline-2-c...)
Show SMILES CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)N1CCc2c(C1)cccc2-c1ccccc1
Show InChI InChI=1S/C25H30N2O3/c1-25(2,3)30-24(29)27-15-8-13-22(27)23(28)26-16-14-21-19(17-26)11-7-12-20(21)18-9-5-4-6-10-18/h4-7,9-12,22H,8,13-17H2,1-3H3/t22-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445164
PNG
((S)-2-(4-(2-aminopyrimidin- 5-yl)indoline-1- carbo...)
Show SMILES Nc1ncc(cn1)-c1cccc2N(CCc12)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C18H18N6O/c19-11-23-7-2-5-16(23)17(25)24-8-6-14-13(3-1-4-15(14)24)12-9-21-18(20)22-10-12/h1,3-4,9-10,16H,2,5-8H2,(H2,20,21,22)/t16-/m0/s1
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445185
PNG
((S)-2-(1-Phenyl-1,4,5,6-tetrahydropyrrolo[3,2-c]py...)
Show SMILES O=C([C@@H]1CCCN1C#N)N1CCc2c1cnn2-c1ccccc1
Show InChI InChI=1S/C17H17N5O/c18-12-20-9-4-7-15(20)17(23)21-10-8-14-16(21)11-19-22(14)13-5-2-1-3-6-13/h1-3,5-6,11,15H,4,7-10H2/t15-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445095
PNG
((S)-2-(4-(Pyridin-2-yl)indoline-1-carbonyl)pyrroli...)
Show SMILES O=C([C@@H]1CCCN1C#N)N1CCc2c1cccc2-c1ccccn1
Show InChI InChI=1S/C19H18N4O/c20-13-22-11-4-8-18(22)19(24)23-12-9-15-14(5-3-7-17(15)23)16-6-1-2-10-21-16/h1-3,5-7,10,18H,4,8-9,11-12H2/t18-/m0/s1
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445106
PNG
((S)-2-(5-phenyl-1,2,3,4- tetrahydroquinoline-1- ca...)
Show SMILES O=C([C@@H]1CCCN1C#N)N1CCCc2c1cccc2-c1ccccc1
Show InChI InChI=1S/C21H21N3O/c22-15-23-13-6-12-20(23)21(25)24-14-5-10-18-17(9-4-11-19(18)24)16-7-2-1-3-8-16/h1-4,7-9,11,20H,5-6,10,12-14H2/t20-/m0/s1
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MISSION THERAPEUTICS LIMITED

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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445127
PNG
((S)-1-cyano-N-methyl-N- (5-phenylisoxazol-3-yl)- p...)
Show SMILES CN(C(=O)[C@@H]1CCCN1C#N)c1cc(on1)-c1ccccc1
Show InChI InChI=1S/C16H16N4O2/c1-19(16(21)13-8-5-9-20(13)11-17)15-10-14(22-18-15)12-6-3-2-4-7-12/h2-4,6-7,10,13H,5,8-9H2,1H3/t13-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445130
PNG
((S)-N-(4-(3- acetamidophenyl)thiazol- 2-yl)-1-cyan...)
Show SMILES CN(C(=O)[C@@H]1CCCN1C#N)c1nc(cs1)-c1cccc(NC(C)=O)c1
Show InChI InChI=1S/C18H19N5O2S/c1-12(24)20-14-6-3-5-13(9-14)15-10-26-18(21-15)22(2)17(25)16-7-4-8-23(16)11-19/h3,5-6,9-10,16H,4,7-8H2,1-2H3,(H,20,24)/t16-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445129
PNG
((S)-N-(4-(4-acetamidophenyl)thiazol-2-yl)-1-cyano-...)
Show SMILES CN(C(=O)[C@@H]1CCCN1C(=O)OC(C)(C)C)c1nc(cs1)-c1ccc(NC(C)=O)cc1
Show InChI InChI=1S/C22H28N4O4S/c1-14(27)23-16-10-8-15(9-11-16)17-13-31-20(24-17)25(5)19(28)18-7-6-12-26(18)21(29)30-22(2,3)4/h8-11,13,18H,6-7,12H2,1-5H3,(H,23,27)/t18-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445142
PNG
(1-(Cyano-L-prolyl)-N-ethyl-4-phenylindoline-6-carb...)
Show SMILES CCNC(=O)c1cc2N(CCc2c(c1)-c1ccccc1)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C23H24N4O2/c1-2-25-22(28)17-13-19(16-7-4-3-5-8-16)18-10-12-27(21(18)14-17)23(29)20-9-6-11-26(20)15-24/h3-5,7-8,13-14,20H,2,6,9-12H2,1H3,(H,25,28)/t20-/m0/s1
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n/an/a 5.50E+4n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445092
PNG
((S)-2-(5-(1H-pyrazol- 5-yl)indoline-1- carbonyl)py...)
Show SMILES O=C([C@@H]1CCCN1C#N)N1CCc2cc(ccc12)-c1ccn[nH]1
Show InChI InChI=1S/C17H17N5O/c18-11-21-8-1-2-16(21)17(23)22-9-6-13-10-12(3-4-15(13)22)14-5-7-19-20-14/h3-5,7,10,16H,1-2,6,8-9H2,(H,19,20)/t16-/m0/s1
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n/an/a 5.50E+4n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445109
PNG
((S)-1-cyano-N-methyl-N-(4- (pyridin-2-yl)thiazol-2...)
Show SMILES CN(C(=O)[C@@H]1CCCN1C#N)c1nc(cs1)-c1ccccn1
Show InChI InChI=1S/C15H15N5OS/c1-19(14(21)13-6-4-8-20(13)10-16)15-18-12(9-22-15)11-5-2-3-7-17-11/h2-3,5,7,9,13H,4,6,8H2,1H3/t13-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445161
PNG
((S)-2-(4-(6-aminopyridin- 2-yl)indoline-1- carbony...)
Show SMILES Nc1cccc(n1)-c1cccc2N(CCc12)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C19H19N5O/c20-12-23-10-3-7-17(23)19(25)24-11-9-14-13(4-1-6-16(14)24)15-5-2-8-18(21)22-15/h1-2,4-6,8,17H,3,7,9-11H2,(H2,21,22)/t17-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445067
PNG
((S)-2-(4-Phenylindoline-1-carbonyl)pyrrolidine-1-c...)
Show SMILES O=C([C@@H]1CCCN1C#N)N1CCc2c1cccc2-c1ccccc1
Show InChI InChI=1S/C20H19N3O/c21-14-22-12-5-10-19(22)20(24)23-13-11-17-16(8-4-9-18(17)23)15-6-2-1-3-7-15/h1-4,6-9,19H,5,10-13H2/t19-/m0/s1
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n/an/a 5.50E+4n/an/an/an/an/an/a



MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM445083
PNG
((S)-2-(4-(4- cyanophenyl)indoline- 1-carbonyl)pyrr...)
Show SMILES O=C([C@@H]1CCCN1C#N)N1CCc2c1cccc2-c1ccc(cc1)C#N
Show InChI InChI=1S/C21H18N4O/c22-13-15-6-8-16(9-7-15)17-3-1-4-19-18(17)10-12-25(19)21(26)20-5-2-11-24(20)14-23/h1,3-4,6-9,20H,2,5,10-12H2/t20-/m0/s1
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM445069
PNG
((S)-2-(4-(3- methoxyphenyl)indoline-1- carbonyl)py...)
Show SMILES COc1cccc(c1)-c1cccc2N(CCc12)C(=O)[C@@H]1CCCN1C#N
Show InChI InChI=1S/C21H21N3O2/c1-26-16-6-2-5-15(13-16)17-7-3-8-19-18(17)10-12-24(19)21(25)20-9-4-11-23(20)14-22/h2-3,5-8,13,20H,4,9-12H2,1H3/t20-/m0/s1
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MISSION THERAPEUTICS LIMITED

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10669234 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%