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Patent code US10669239

Compile Data Set for Download or QSAR
Found 74 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412291
PNG
(US10399945, Example 30 | US10669239, Compound 30)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)c(nc1-c1cn[nH]c1)C1CCOCC1
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n/an/a<50n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412295
PNG
(US10399945, Example 34a | US10669239, Compound 34a)
Show SMILES Cc1ncc(cn1)-c1nc(c(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccc(F)cc23)cc1C)-c1ccccc1
Show InChI InChI=1S/C30H30FN5O2/c1-17-12-24(27(19-8-6-5-7-9-19)35-26(17)20-15-32-18(2)33-16-20)34-29(38)36-28-22-13-21(31)10-11-23(22)30(3,4)14-25(28)37/h5-13,15-16,25,28,37H,14H2,1-4H3,(H2,34,36,38)/t25-,28-/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412297
PNG
(US10399945, Example 35a | US10669239, Compound 35a)
Show SMILES Cc1ncc(cn1)-c1nc(c(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3cc(F)ccc23)cc1C)-c1ccccc1
Show InChI InChI=1S/C30H30FN5O2/c1-17-12-24(27(19-8-6-5-7-9-19)35-26(17)20-15-32-18(2)33-16-20)34-29(38)36-28-22-11-10-21(31)13-23(22)30(3,4)14-25(28)37/h5-13,15-16,25,28,37H,14H2,1-4H3,(H2,34,36,38)/t25-,28-/m1/s1
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n/an/a<50n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412306
PNG
(US10399945, Example 41 | US10669239, Compound 41)
Show SMILES Cc1nnc(CNC(=O)c2nc(c(NC(=O)NC3[C@H](O)CC(C)(C)c4cc(F)c(F)cc34)cc2C)-c2ccccc2)o1
Show InChI InChI=1S/C30H30F2N6O4/c1-15-10-22(34-29(41)36-27-18-11-20(31)21(32)12-19(18)30(3,4)13-23(27)39)26(17-8-6-5-7-9-17)35-25(15)28(40)33-14-24-38-37-16(2)42-24/h5-12,23,27,39H,13-14H2,1-4H3,(H,33,40)(H2,34,36,41)/t23-,27?/m1/s1
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n/an/a<50n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412309
PNG
(US10399945, Example 42 | US10669239, Compound 42)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)c(nc1C(=O)NCC(C)(C)O)-c1ccccc1
Show InChI InChI=1S/C30H34F2N4O4/c1-16-11-22(25(17-9-7-6-8-10-17)35-24(16)27(38)33-15-30(4,5)40)34-28(39)36-26-18-12-20(31)21(32)13-19(18)29(2,3)14-23(26)37/h6-13,23,26,37,40H,14-15H2,1-5H3,(H,33,38)(H2,34,36,39)/t23-,26-/m1/s1
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n/an/a<50n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM445317
PNG
(US10669239, Compound 44b)
Show SMILES Cc1ncc(cn1)-c1nc(c(NC(=O)N[C@@H]2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)cc1C)-c1ccccc1
Show InChI InChI=1S/C30H29F2N5O2/c1-16-10-24(27(18-8-6-5-7-9-18)36-26(16)19-14-33-17(2)34-15-19)35-29(39)37-28-20-11-22(31)23(32)12-21(20)30(3,4)13-25(28)38/h5-12,14-15,25,28,38H,13H2,1-4H3,(H2,35,37,39)/t25-,28+/m1/s1
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n/an/a<50n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412322
PNG
(US10399945, Example 51 | US10669239, Compound 51)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)c(nc1-c1cnn(C)c1)-c1ccccc1
Show InChI InChI=1S/C29H29F2N5O2/c1-16-10-23(26(17-8-6-5-7-9-17)34-25(16)18-14-32-36(4)15-18)33-28(38)35-27-19-11-21(30)22(31)12-20(19)29(2,3)13-24(27)37/h5-12,14-15,24,27,37H,13H2,1-4H3,(H2,33,35,38)/t24-,27-/m1/s1
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n/an/a<50n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412324
PNG
(US10399945, Example 53 | US10669239, Compound 53)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)c(nc1-c1cn[nH]c1)-c1ccccc1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM445330
PNG
(US10669239, Compound 55)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)c(nc1-c1ccc(CO)nc1)-c1ccccc1
Show InChI InChI=1S/C31H30F2N4O3/c1-17-11-25(28(18-7-5-4-6-8-18)36-27(17)19-9-10-20(16-38)34-15-19)35-30(40)37-29-21-12-23(32)24(33)13-22(21)31(2,3)14-26(29)39/h4-13,15,26,29,38-39H,14,16H2,1-3H3,(H2,35,37,40)/t26-,29-/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412265
PNG
(US10399945, Example 10 | US10399945, Example 4 | U...)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)c(nc1-c1cnn(C)c1)-c1ccccc1
Show InChI InChI=1S/C29H31N5O2/c1-18-14-23(26(19-10-6-5-7-11-19)32-25(18)20-16-30-34(4)17-20)31-28(36)33-27-21-12-8-9-13-22(21)29(2,3)15-24(27)35/h5-14,16-17,24,27,35H,15H2,1-4H3,(H2,31,33,36)/t24-,27-/m1/s1
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n/an/a<50n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412283
PNG
(US10399945, Example 22 | US10669239, Compound 22)
Show SMILES Cc1cnc(c(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3cc(Br)ccc23)c1)-c1ccccc1
Show InChI InChI=1S/C25H26BrN3O2/c1-15-11-20(22(27-14-15)16-7-5-4-6-8-16)28-24(31)29-23-18-10-9-17(26)12-19(18)25(2,3)13-21(23)30/h4-12,14,21,23,30H,13H2,1-3H3,(H2,28,29,31)/t21-,23-/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412287
PNG
(US10399945, Example 26 | US10669239, Compound 26)
Show SMILES Cc1cnc(C2CCOCC2)c(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)c1
Show InChI InChI=1S/C24H31N3O3/c1-15-12-19(21(25-14-15)16-8-10-30-11-9-16)26-23(29)27-22-17-6-4-5-7-18(17)24(2,3)13-20(22)28/h4-7,12,14,16,20,22,28H,8-11,13H2,1-3H3,(H2,26,27,29)/t20-,22-/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412292
PNG
(US10399945, Example 31 | US10669239, Compound 31)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)c(nc1-c1ccc(O)nc1)C1CCOCC1
Show InChI InChI=1S/C29H34N4O4/c1-17-14-22(26(18-10-12-37-13-11-18)32-25(17)19-8-9-24(35)30-16-19)31-28(36)33-27-20-6-4-5-7-21(20)29(2,3)15-23(27)34/h4-9,14,16,18,23,27,34H,10-13,15H2,1-3H3,(H,30,35)(H2,31,33,36)/t23-,27-/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412319
PNG
(US10399945, Example 48b | US10669239, Compound 48b)
Show SMILES Cc1cc(NC(=O)N[C@@H]2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)c(nc1-c1ccn(C)n1)-c1ccccc1
Show InChI InChI=1S/C29H29F2N5O2/c1-16-12-23(26(17-8-6-5-7-9-17)33-25(16)22-10-11-36(4)35-22)32-28(38)34-27-18-13-20(30)21(31)14-19(18)29(2,3)15-24(27)37/h5-14,24,27,37H,15H2,1-4H3,(H2,32,34,38)/t24-,27+/m1/s1
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n/an/a<50n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412266
PNG
(US10399945, Example 18 | US10399945, Example 5 | U...)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)c(nc1-c1cn[nH]c1)-c1ccccc1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM445276
PNG
(US10669239, Compound 11)
Show SMILES Cc1cc(NC(=O)NC2[C@H](O)CC(C)(C)c3ccccc23)c(nc1-c1cncc(c1)C(F)(F)F)-c1ccccc1
Show InChI InChI=1S/C31H29F3N4O2/c1-18-13-24(36-29(40)38-28-22-11-7-8-12-23(22)30(2,3)15-25(28)39)27(19-9-5-4-6-10-19)37-26(18)20-14-21(17-35-16-20)31(32,33)34/h4-14,16-17,25,28,39H,15H2,1-3H3,(H2,36,38,40)/t25-,28?/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM445280
PNG
(US10669239, Compound 15)
Show SMILES Cc1cc(NC(=O)NC2[C@H](O)CC(C)(C)c3ccccc23)c(nc1-c1cnc(nc1)S(F)(F)F)-c1ccccc1
Show InChI InChI=1S/C29H28F3N5O2S/c1-17-13-22(35-27(39)37-26-20-11-7-8-12-21(20)29(2,3)14-23(26)38)25(18-9-5-4-6-10-18)36-24(17)19-15-33-28(34-16-19)40(30,31)32/h4-13,15-16,23,26,38H,14H2,1-3H3,(H2,35,37,39)/t23-,26?/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412286
PNG
(US10399945, Example 25 | US10669239, Compound 25)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)c(nc1C(=O)NCC(C)(C)O)-c1ccccc1
Show InChI InChI=1S/C30H36N4O4/c1-18-15-22(25(19-11-7-6-8-12-19)33-24(18)27(36)31-17-30(4,5)38)32-28(37)34-26-20-13-9-10-14-21(20)29(2,3)16-23(26)35/h6-15,23,26,35,38H,16-17H2,1-5H3,(H,31,36)(H2,32,34,37)/t23-,26-/m1/s1
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n/an/a<50n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM445297
PNG
(US10669239, Compound 32)
Show SMILES Cc1cnc(c(NC(=O)NC2[C@H](O)CC(C)(C)c3ccc(Br)cc23)c1)-c1ccccc1
Show InChI InChI=1S/C25H26BrN3O2/c1-15-11-20(22(27-14-15)16-7-5-4-6-8-16)28-24(31)29-23-18-12-17(26)9-10-19(18)25(2,3)13-21(23)30/h4-12,14,21,23,30H,13H2,1-3H3,(H2,28,29,31)/t21-,23?/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412300
PNG
(US10399945, Example 37 | US10399945, Example 37a |...)
Show SMILES Cc1cnc(c(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)c1)-c1ccccc1
Show InChI InChI=1S/C25H25F2N3O2/c1-14-9-20(22(28-13-14)15-7-5-4-6-8-15)29-24(32)30-23-16-10-18(26)19(27)11-17(16)25(2,3)12-21(23)31/h4-11,13,21,23,31H,12H2,1-3H3,(H2,29,30,32)/t21-,23-/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412302
PNG
(US10399945, Example 37b | US10669239, Compound 37b)
Show SMILES Cc1cnc(c(NC(=O)N[C@@H]2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)c1)-c1ccccc1
Show InChI InChI=1S/C25H25F2N3O2/c1-14-9-20(22(28-13-14)15-7-5-4-6-8-15)29-24(32)30-23-16-10-18(26)19(27)11-17(16)25(2,3)12-21(23)31/h4-11,13,21,23,31H,12H2,1-3H3,(H2,29,30,32)/t21-,23+/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM445315
PNG
(US10669239, Compound 44)
Show SMILES Cc1ncc(cn1)-c1nc(c(NC(=O)NC2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)cc1C)-c1ccccc1
Show InChI InChI=1S/C30H29F2N5O2/c1-16-10-24(27(18-8-6-5-7-9-18)36-26(16)19-14-33-17(2)34-15-19)35-29(39)37-28-20-11-22(31)23(32)12-21(20)30(3,4)13-25(28)38/h5-12,14-15,25,28,38H,13H2,1-4H3,(H2,35,37,39)/t25-,28?/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM445318
PNG
(US10669239, Compound 45)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)c(nc1-c1ccc(CO)cc1)-c1ccccc1
Show InChI InChI=1S/C32H31F2N3O3/c1-18-13-26(29(20-7-5-4-6-8-20)36-28(18)21-11-9-19(17-38)10-12-21)35-31(40)37-30-22-14-24(33)25(34)15-23(22)32(2,3)16-27(30)39/h4-15,27,30,38-39H,16-17H2,1-3H3,(H2,35,37,40)/t27-,30-/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412315
PNG
(US10399945, Example 46 | US10669239, Compound 46)
Show SMILES Cc1cc(NC(=O)NC2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)c(nc1-c1cccc(CO)c1)-c1ccccc1
Show InChI InChI=1S/C32H31F2N3O3/c1-18-12-26(29(20-9-5-4-6-10-20)36-28(18)21-11-7-8-19(13-21)17-38)35-31(40)37-30-22-14-24(33)25(34)15-23(22)32(2,3)16-27(30)39/h4-15,27,30,38-39H,16-17H2,1-3H3,(H2,35,37,40)/t27-,30?/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412262
PNG
(US10399945, Example 1 | US10669239, Compound 1)
Show SMILES CC1(C)C[C@@H](O)[C@H](NC(=O)Nc2cccnc2-c2ccccc2)c2ccccc12
Show InChI InChI=1S/C24H25N3O2/c1-24(2)15-20(28)22(17-11-6-7-12-18(17)24)27-23(29)26-19-13-8-14-25-21(19)16-9-4-3-5-10-16/h3-14,20,22,28H,15H2,1-2H3,(H2,26,27,29)/t20-,22-/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412277
PNG
(US10399945, Example 16 | US10669239, Compound 16)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)c(nc1-c1ccc(cc1)C#N)-c1ccccc1
Show InChI InChI=1S/C32H30N4O2/c1-20-17-26(34-31(38)36-30-24-11-7-8-12-25(24)32(2,3)18-27(30)37)29(22-9-5-4-6-10-22)35-28(20)23-15-13-21(19-33)14-16-23/h4-17,27,30,37H,18H2,1-3H3,(H2,34,36,38)/t27-,30-/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM445331
PNG
(US10669239, Compound 56)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)c(nc1-c1ccnc(CO)c1)-c1ccccc1
Show InChI InChI=1S/C31H30F2N4O3/c1-17-11-25(28(18-7-5-4-6-8-18)36-27(17)19-9-10-34-20(12-19)16-38)35-30(40)37-29-21-13-23(32)24(33)14-22(21)31(2,3)15-26(29)39/h4-14,26,29,38-39H,15-16H2,1-3H3,(H2,35,37,40)/t26-,29-/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412298
PNG
(US10399945, Example 35b | US10669239, Compound 35b)
Show SMILES Cc1ncc(cn1)-c1nc(c(NC(=O)N[C@@H]2[C@H](O)CC(C)(C)c3cc(F)ccc23)cc1C)-c1ccccc1
Show InChI InChI=1S/C30H30FN5O2/c1-17-12-24(27(19-8-6-5-7-9-19)35-26(17)20-15-32-18(2)33-16-20)34-29(38)36-28-22-11-10-21(31)13-23(22)30(3,4)14-25(28)37/h5-13,15-16,25,28,37H,14H2,1-4H3,(H2,34,36,38)/t25-,28+/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412308
PNG
(US10399945, Example 41b | US10669239, Compound 41b)
Show SMILES Cc1nnc(CNC(=O)c2nc(c(NC(=O)N[C@@H]3[C@H](O)CC(C)(C)c4cc(F)c(F)cc34)cc2C)-c2ccccc2)o1
Show InChI InChI=1S/C30H30F2N6O4/c1-15-10-22(34-29(41)36-27-18-11-20(31)21(32)12-19(18)30(3,4)13-23(27)39)26(17-8-6-5-7-9-17)35-25(15)28(40)33-14-24-38-37-16(2)42-24/h5-12,23,27,39H,13-14H2,1-4H3,(H,33,40)(H2,34,36,41)/t23-,27+/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM445329
PNG
(US10669239, Compound 54)
Show SMILES Cc1cc(NC(=O)NC2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)c(nc1-c1cnc(nc1)C(C)(C)O)-c1ccccc1
Show InChI InChI=1S/C32H33F2N5O3/c1-17-11-24(37-30(41)39-28-20-12-22(33)23(34)13-21(20)31(2,3)14-25(28)40)27(18-9-7-6-8-10-18)38-26(17)19-15-35-29(36-16-19)32(4,5)42/h6-13,15-16,25,28,40,42H,14H2,1-5H3,(H2,37,39,41)/t25-,28?/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412267
PNG
(US10399945, Example 6 | US10669239, Compound 20)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)c(nc1-c1ccc(O)nc1)-c1ccccc1
Show InChI InChI=1S/C30H30N4O3/c1-18-15-23(27(19-9-5-4-6-10-19)33-26(18)20-13-14-25(36)31-17-20)32-29(37)34-28-21-11-7-8-12-22(21)30(2,3)16-24(28)35/h4-15,17,24,28,35H,16H2,1-3H3,(H,31,36)(H2,32,34,37)/t24-,28-/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412263
PNG
(US10399945, Example 2 | US10399945, Example 7 | US...)
Show SMILES Cc1cnc(c(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)c1)-c1ccccc1
Show InChI InChI=1S/C25H27N3O2/c1-16-13-20(22(26-15-16)17-9-5-4-6-10-17)27-24(30)28-23-18-11-7-8-12-19(18)25(2,3)14-21(23)29/h4-13,15,21,23,29H,14H2,1-3H3,(H2,27,28,30)/t21-,23-/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412280
PNG
(US10399945, Example 19 | US10669239, Compound 19)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)c(nc1-c1cnc(O)nc1)-c1ccccc1
Show InChI InChI=1S/C29H29N5O3/c1-17-13-22(25(18-9-5-4-6-10-18)33-24(17)19-15-30-27(36)31-16-19)32-28(37)34-26-20-11-7-8-12-21(20)29(2,3)14-23(26)35/h4-13,15-16,23,26,35H,14H2,1-3H3,(H,30,31,36)(H2,32,34,37)/t23-,26-/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM445298
PNG
(US10669239, Compound 33)
Show SMILES Cc1cnc(C2CCOCC2)c(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccc(CO)cc23)c1
Show InChI InChI=1S/C25H33N3O4/c1-15-10-20(22(26-13-15)17-6-8-32-9-7-17)27-24(31)28-23-18-11-16(14-29)4-5-19(18)25(2,3)12-21(23)30/h4-5,10-11,13,17,21,23,29-30H,6-9,12,14H2,1-3H3,(H2,27,28,31)/t21-,23-/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412296
PNG
(US10399945, Example 34b | US10669239, Compound 34b)
Show SMILES Cc1ncc(cn1)-c1nc(c(NC(=O)N[C@@H]2[C@H](O)CC(C)(C)c3ccc(F)cc23)cc1C)-c1ccccc1
Show InChI InChI=1S/C30H30FN5O2/c1-17-12-24(27(19-8-6-5-7-9-19)35-26(17)20-15-32-18(2)33-16-20)34-29(38)36-28-22-13-21(31)10-11-23(22)30(3,4)14-25(28)37/h5-13,15-16,25,28,37H,14H2,1-4H3,(H2,34,36,38)/t25-,28+/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412304
PNG
(US10399945, Example 39 | US10669239, Compound 39)
Show SMILES Cc1ccc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)c(n1)-c1ccccc1
Show InChI InChI=1S/C25H25F2N3O2/c1-14-9-10-20(22(28-14)15-7-5-4-6-8-15)29-24(32)30-23-16-11-18(26)19(27)12-17(16)25(2,3)13-21(23)31/h4-12,21,23,31H,13H2,1-3H3,(H2,29,30,32)/t21-,23-/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412311
PNG
(US10399945, Example 44 | US10399945, Example 44a |...)
Show SMILES Cc1ncc(cn1)-c1nc(c(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)cc1C)-c1ccccc1
Show InChI InChI=1S/C30H29F2N5O2/c1-16-10-24(27(18-8-6-5-7-9-18)36-26(16)19-14-33-17(2)34-15-19)35-29(39)37-28-20-11-22(31)23(32)12-21(20)30(3,4)13-25(28)38/h5-12,14-15,25,28,38H,13H2,1-4H3,(H2,35,37,39)/t25-,28-/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412318
PNG
(US10399945, Example 48a | US10669239, Compound 48a)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)c(nc1-c1ccn(C)n1)-c1ccccc1
Show InChI InChI=1S/C29H29F2N5O2/c1-16-12-23(26(17-8-6-5-7-9-17)33-25(16)22-10-11-36(4)35-22)32-28(38)34-27-18-13-20(30)21(31)14-19(18)29(2,3)15-24(27)37/h5-14,24,27,37H,15H2,1-4H3,(H2,32,34,38)/t24-,27-/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM445324
PNG
(US10669239, Compound 49)
Show SMILES Cc1cc(cnn1)-c1nc(c(NC(=O)NC2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)cc1C)-c1ccccc1
Show InChI InChI=1S/C30H29F2N5O2/c1-16-10-24(27(18-8-6-5-7-9-18)35-26(16)19-11-17(2)37-33-15-19)34-29(39)36-28-20-12-22(31)23(32)13-21(20)30(3,4)14-25(28)38/h5-13,15,25,28,38H,14H2,1-4H3,(H2,34,36,39)/t25-,28?/m1/s1
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n/an/a<50n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412278
PNG
(US10399945, Example 17 | US10669239, Compound 17)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)c(nc1-c1ccnc(c1)C(F)(F)F)-c1ccccc1
Show InChI InChI=1S/C31H29F3N4O2/c1-18-15-23(36-29(40)38-28-21-11-7-8-12-22(21)30(2,3)17-24(28)39)27(19-9-5-4-6-10-19)37-26(18)20-13-14-35-25(16-20)31(32,33)34/h4-16,24,28,39H,17H2,1-3H3,(H2,36,38,40)/t24-,28-/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412265
PNG
(US10399945, Example 10 | US10399945, Example 4 | U...)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)c(nc1-c1cnn(C)c1)-c1ccccc1
Show InChI InChI=1S/C29H31N5O2/c1-18-14-23(26(19-10-6-5-7-11-19)32-25(18)20-16-30-34(4)17-20)31-28(36)33-27-21-12-8-9-13-22(21)29(2,3)15-24(27)35/h5-14,16-17,24,27,35H,15H2,1-4H3,(H2,31,33,36)/t24-,27-/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412289
PNG
(US10399945, Example 28 | US10669239, Compound 28)
Show SMILES Cc1ncc(cn1)-c1nc(C2CCOCC2)c(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)cc1C
Show InChI InChI=1S/C29H35N5O3/c1-17-13-23(26(19-9-11-37-12-10-19)33-25(17)20-15-30-18(2)31-16-20)32-28(36)34-27-21-7-5-6-8-22(21)29(3,4)14-24(27)35/h5-8,13,15-16,19,24,27,35H,9-12,14H2,1-4H3,(H2,32,34,36)/t24-,27-/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412299
PNG
(US10399945, Example 36 | US10669239, Compound 36)
Show SMILES CC1(C)C[C@@H](O)[C@H](NC(=O)Nc2cccnc2-c2ccccc2)c2cc(F)c(F)cc12
Show InChI InChI=1S/C24H23F2N3O2/c1-24(2)13-20(30)22(15-11-17(25)18(26)12-16(15)24)29-23(31)28-19-9-6-10-27-21(19)14-7-4-3-5-8-14/h3-12,20,22,30H,13H2,1-2H3,(H2,28,29,31)/t20-,22-/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412305
PNG
(US10399945, Example 40 | US10669239, Compound 40)
Show SMILES Cc1cc(NC(=O)NC2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)c(nc1C(N)=O)-c1ccccc1
Show InChI InChI=1S/C26H26F2N4O3/c1-13-9-19(22(31-21(13)24(29)34)14-7-5-4-6-8-14)30-25(35)32-23-15-10-17(27)18(28)11-16(15)26(2,3)12-20(23)33/h4-11,20,23,33H,12H2,1-3H3,(H2,29,34)(H2,30,32,35)/t20-,23?/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412307
PNG
(US10399945, Example 41a | US10669239, Compound 41a)
Show SMILES Cc1nnc(CNC(=O)c2nc(c(NC(=O)N[C@H]3[C@H](O)CC(C)(C)c4cc(F)c(F)cc34)cc2C)-c2ccccc2)o1
Show InChI InChI=1S/C30H30F2N6O4/c1-15-10-22(34-29(41)36-27-18-11-20(31)21(32)12-19(18)30(3,4)13-23(27)39)26(17-8-6-5-7-9-17)35-25(15)28(40)33-14-24-38-37-16(2)42-24/h5-12,23,27,39H,13-14H2,1-4H3,(H,33,40)(H2,34,36,41)/t23-,27-/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412316
PNG
(US10399945, Example 47 | US10669239, Compound 47)
Show SMILES Cc1cc(NC(=O)NC2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)c(nc1-c1cccc(c1)C#N)-c1ccccc1
Show InChI InChI=1S/C32H28F2N4O2/c1-18-12-26(29(20-9-5-4-6-10-20)37-28(18)21-11-7-8-19(13-21)17-35)36-31(40)38-30-22-14-24(33)25(34)15-23(22)32(2,3)16-27(30)39/h4-15,27,30,39H,16H2,1-3H3,(H2,36,38,40)/t27-,30?/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412317
PNG
(US10399945, Example 48 | US10669239, Compound 48)
Show SMILES Cc1cc(NC(=O)NC2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)c(nc1-c1ccn(C)n1)-c1ccccc1
Show InChI InChI=1S/C29H29F2N5O2/c1-16-12-23(26(17-8-6-5-7-9-17)33-25(16)22-10-11-36(4)35-22)32-28(38)34-27-18-13-20(30)21(31)14-19(18)29(2,3)15-24(27)37/h5-14,24,27,37H,15H2,1-4H3,(H2,32,34,38)/t24-,27?/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412323
PNG
(US10399945, Example 52 | US10669239, Compound 52)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)c(nc1-c1ccc(cc1)C#N)-c1ccccc1
Show InChI InChI=1S/C32H28F2N4O2/c1-18-13-26(29(20-7-5-4-6-8-20)37-28(18)21-11-9-19(17-35)10-12-21)36-31(40)38-30-22-14-24(33)25(34)15-23(22)32(2,3)16-27(30)39/h4-15,27,30,39H,16H2,1-3H3,(H2,36,38,40)/t27-,30-/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412269
PNG
(US10399945, Example 8 | US10669239, Compound 8)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)c(nc1CO)-c1ccccc1
Show InChI InChI=1S/C26H29N3O3/c1-16-13-20(23(27-21(16)15-30)17-9-5-4-6-10-17)28-25(32)29-24-18-11-7-8-12-19(18)26(2,3)14-22(24)31/h4-13,22,24,30-31H,14-15H2,1-3H3,(H2,28,29,32)/t22-,24-/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412264
PNG
(US10399945, Example 3 | US10399945, Example 9 | US...)
Show SMILES Cc1ncc(cn1)-c1nc(c(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)cc1C)-c1ccccc1
Show InChI InChI=1S/C30H31N5O2/c1-18-14-24(27(20-10-6-5-7-11-20)34-26(18)21-16-31-19(2)32-17-21)33-29(37)35-28-22-12-8-9-13-23(22)30(3,4)15-25(28)36/h5-14,16-17,25,28,36H,15H2,1-4H3,(H2,33,35,37)/t25-,28-/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM445278
PNG
(US10669239, Compound 13)
Show SMILES Cc1cc(NC(=O)NC2[C@H](O)CC(C)(C)c3ccccc23)c(nc1-c1ccc(nc1)C#N)-c1ccccc1
Show InChI InChI=1S/C31H29N5O2/c1-19-15-25(34-30(38)36-29-23-11-7-8-12-24(23)31(2,3)16-26(29)37)28(20-9-5-4-6-10-20)35-27(19)21-13-14-22(17-32)33-18-21/h4-15,18,26,29,37H,16H2,1-3H3,(H2,34,36,38)/t26-,29?/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM445286
PNG
(US10669239, Compound 21)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)c(nc1-c1cnc(nc1)C(C)(C)O)-c1ccccc1
Show InChI InChI=1S/C32H35N5O3/c1-19-15-24(35-30(39)37-28-22-13-9-10-14-23(22)31(2,3)16-25(28)38)27(20-11-7-6-8-12-20)36-26(19)21-17-33-29(34-18-21)32(4,5)40/h6-15,17-18,25,28,38,40H,16H2,1-5H3,(H2,35,37,39)/t25-,28-/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412284
PNG
(US10399945, Example 23 | US10669239, Compound 23)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3cc(Br)ccc23)c(nc1C(N)=O)-c1ccccc1
Show InChI InChI=1S/C26H27BrN4O3/c1-14-11-19(22(30-21(14)24(28)33)15-7-5-4-6-8-15)29-25(34)31-23-17-10-9-16(27)12-18(17)26(2,3)13-20(23)32/h4-12,20,23,32H,13H2,1-3H3,(H2,28,33)(H2,29,31,34)/t20-,23-/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM445304
PNG
(US10669239, Compound 37)
Show SMILES Cc1cnc(c(NC(=O)NC2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)c1)-c1ccccc1
Show InChI InChI=1S/C25H25F2N3O2/c1-14-9-20(22(28-13-14)15-7-5-4-6-8-15)29-24(32)30-23-16-10-18(26)19(27)11-17(16)25(2,3)12-21(23)31/h4-11,13,21,23,31H,12H2,1-3H3,(H2,29,30,32)/t21-,23?/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM445314
PNG
(US10669239, Compound 43)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)c(nc1CO)-c1ccccc1
Show InChI InChI=1S/C26H27F2N3O3/c1-14-9-20(23(29-21(14)13-32)15-7-5-4-6-8-15)30-25(34)31-24-16-10-18(27)19(28)11-17(16)26(2,3)12-22(24)33/h4-11,22,24,32-33H,12-13H2,1-3H3,(H2,30,31,34)/t22-,24-/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM445277
PNG
(US10669239, Compound 12 | US10669239, Compound 14)
Show SMILES Cc1cc(NC(=O)NC2[C@H](O)CC(C)(C)c3ccccc23)c(nc1-c1ccc(nc1)S(C)(=O)=O)-c1ccccc1
Show InChI InChI=1S/C31H32N4O4S/c1-19-16-24(33-30(37)35-29-22-12-8-9-13-23(22)31(2,3)17-25(29)36)28(20-10-6-5-7-11-20)34-27(19)21-14-15-26(32-18-21)40(4,38)39/h5-16,18,25,29,36H,17H2,1-4H3,(H2,33,35,37)/t25-,29?/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM445277
PNG
(US10669239, Compound 12 | US10669239, Compound 14)
Show SMILES Cc1cc(NC(=O)NC2[C@H](O)CC(C)(C)c3ccccc23)c(nc1-c1ccc(nc1)S(C)(=O)=O)-c1ccccc1
Show InChI InChI=1S/C31H32N4O4S/c1-19-16-24(33-30(37)35-29-22-12-8-9-13-23(22)31(2,3)17-25(29)36)28(20-10-6-5-7-11-20)34-27(19)21-14-15-26(32-18-21)40(4,38)39/h5-16,18,25,29,36H,17H2,1-4H3,(H2,33,35,37)/t25-,29?/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412290
PNG
(US10399945, Example 29 | US10669239, Compound 29)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)c(nc1-c1cnn(C)c1)C1CCOCC1
Show InChI InChI=1S/C28H35N5O3/c1-17-13-22(25(18-9-11-36-12-10-18)31-24(17)19-15-29-33(4)16-19)30-27(35)32-26-20-7-5-6-8-21(20)28(2,3)14-23(26)34/h5-8,13,15-16,18,23,26,34H,9-12,14H2,1-4H3,(H2,30,32,35)/t23-,26-/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412263
PNG
(US10399945, Example 2 | US10399945, Example 7 | US...)
Show SMILES Cc1cnc(c(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)c1)-c1ccccc1
Show InChI InChI=1S/C25H27N3O2/c1-16-13-20(22(26-15-16)17-9-5-4-6-10-17)27-24(30)28-23-18-11-7-8-12-19(18)25(2,3)14-21(23)29/h4-13,15,21,23,29H,14H2,1-3H3,(H2,27,28,30)/t21-,23-/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412264
PNG
(US10399945, Example 3 | US10399945, Example 9 | US...)
Show SMILES Cc1ncc(cn1)-c1nc(c(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)cc1C)-c1ccccc1
Show InChI InChI=1S/C30H31N5O2/c1-18-14-24(27(20-10-6-5-7-11-20)34-26(18)21-16-31-19(2)32-17-21)33-29(37)35-28-22-12-8-9-13-23(22)30(3,4)15-25(28)36/h5-14,16-17,25,28,36H,15H2,1-4H3,(H2,33,35,37)/t25-,28-/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412265
PNG
(US10399945, Example 10 | US10399945, Example 4 | U...)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)c(nc1-c1cnn(C)c1)-c1ccccc1
Show InChI InChI=1S/C29H31N5O2/c1-18-14-23(26(19-10-6-5-7-11-19)32-25(18)20-16-30-34(4)17-20)31-28(36)33-27-21-12-8-9-13-22(21)29(2,3)15-24(27)35/h5-14,16-17,24,27,35H,15H2,1-4H3,(H2,31,33,36)/t24-,27-/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412267
PNG
(US10399945, Example 6 | US10669239, Compound 20)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)c(nc1-c1ccc(O)nc1)-c1ccccc1
Show InChI InChI=1S/C30H30N4O3/c1-18-15-23(27(19-9-5-4-6-10-19)33-26(18)20-13-14-25(36)31-17-20)32-29(37)34-28-21-11-7-8-12-22(21)30(2,3)16-24(28)35/h4-15,17,24,28,35H,16H2,1-3H3,(H,31,36)(H2,32,34,37)/t24-,28-/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412285
PNG
(US10399945, Example 24 | US10669239, Compound 24)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)c(nc1C(N)=O)-c1ccccc1
Show InChI InChI=1S/C26H28N4O3/c1-15-13-19(22(29-21(15)24(27)32)16-9-5-4-6-10-16)28-25(33)30-23-17-11-7-8-12-18(17)26(2,3)14-20(23)31/h4-13,20,23,31H,14H2,1-3H3,(H2,27,32)(H2,28,30,33)/t20-,23-/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412303
PNG
(US10399945, Example 38 | US10669239, Compound 38)
Show SMILES Cc1ccnc(-c2ccccc2)c1NC(=O)N[C@H]1[C@H](O)CC(C)(C)c2cc(F)c(F)cc12
Show InChI InChI=1S/C25H25F2N3O2/c1-14-9-10-28-22(15-7-5-4-6-8-15)21(14)29-24(32)30-23-16-11-18(26)19(27)12-17(16)25(2,3)13-20(23)31/h4-12,20,23,31H,13H2,1-3H3,(H2,29,30,32)/t20-,23-/m1/s1
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n/an/a 525n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM445333
PNG
(US10669239, Compound 58)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)c(nc1C(N)=O)C1CCOCC1
Show InChI InChI=1S/C25H30F2N4O4/c1-12-8-18(21(30-20(12)23(28)33)13-4-6-35-7-5-13)29-24(34)31-22-14-9-16(26)17(27)10-15(14)25(2,3)11-19(22)32/h8-10,13,19,22,32H,4-7,11H2,1-3H3,(H2,28,33)(H2,29,31,34)/t19-,22-/m1/s1
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n/an/a 525n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412330
PNG
(US10399945, Example 59 | US10669239, Compound 59)
Show SMILES Cc1ncc(cn1)-c1nc(C2CCOCC2)c(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)cc1C
Show InChI InChI=1S/C29H33F2N5O3/c1-15-9-23(26(17-5-7-39-8-6-17)35-25(15)18-13-32-16(2)33-14-18)34-28(38)36-27-19-10-21(30)22(31)11-20(19)29(3,4)12-24(27)37/h9-11,13-14,17,24,27,37H,5-8,12H2,1-4H3,(H2,34,36,38)/t24-,27-/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM445336
PNG
(US10669239, Compound 61)
Show SMILES Cc1cc(NC(=O)NC2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)c(nc1-c1cn[nH]c1)C1CCOCC1
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n/an/a 525n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412334
PNG
(US10399945, Example 61b | US10669239, Compound 61a)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)c(nc1-c1cn[nH]c1)C1CCOCC1
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n/an/a 525n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM445339
PNG
(US10669239, Compound 62)
Show SMILES Cc1cc(NC(=O)NC2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)c(nc1-c1cnc(O)nc1)C1CCOCC1
Show InChI InChI=1S/C28H31F2N5O4/c1-14-8-21(24(15-4-6-39-7-5-15)34-23(14)16-12-31-26(37)32-13-16)33-27(38)35-25-17-9-19(29)20(30)10-18(17)28(2,3)11-22(25)36/h8-10,12-13,15,22,25,36H,4-7,11H2,1-3H3,(H,31,32,37)(H2,33,35,38)/t22-,25?/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412328
PNG
(US10399945, Example 57 | US10669239, Compound 57)
Show SMILES Cc1cnc(C2CCOCC2)c(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)c1
Show InChI InChI=1S/C24H29F2N3O3/c1-13-8-19(21(27-12-13)14-4-6-32-7-5-14)28-23(31)29-22-15-9-17(25)18(26)10-16(15)24(2,3)11-20(22)30/h8-10,12,14,20,22,30H,4-7,11H2,1-3H3,(H2,28,29,31)/t20-,22-/m1/s1
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n/an/a 525n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412288
PNG
(US10399945, Example 27 | US10669239, Compound 27)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)c(nc1C(N)=O)C1CCOCC1
Show InChI InChI=1S/C25H32N4O4/c1-14-12-18(21(28-20(14)23(26)31)15-8-10-33-11-9-15)27-24(32)29-22-16-6-4-5-7-17(16)25(2,3)13-19(22)30/h4-7,12,15,19,22,30H,8-11,13H2,1-3H3,(H2,26,31)(H2,27,29,32)/t19-,22-/m1/s1
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n/an/a 525n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412332
PNG
(US10399945, Example 61 | US10669239, Compound 60)
Show SMILES Cc1cc(NC(=O)NC2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)c(nc1C(=O)NCC(C)(C)O)C1CCOCC1
Show InChI InChI=1S/C29H38F2N4O5/c1-15-10-21(24(16-6-8-40-9-7-16)34-23(15)26(37)32-14-29(4,5)39)33-27(38)35-25-17-11-19(30)20(31)12-18(17)28(2,3)13-22(25)36/h10-12,16,22,25,36,39H,6-9,13-14H2,1-5H3,(H,32,37)(H2,33,35,38)/t22-,25?/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM445338
PNG
(US10669239, Compound 61b)
Show SMILES Cc1cc(NC(=O)N[C@@H]2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)c(nc1-c1cn[nH]c1)C1CCOCC1
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n/an/a 525n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM445325
PNG
(US10669239, Compound 50)
Show SMILES Cc1ncc(s1)-c1nc(c(NC(=O)N[C@@H]2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)cc1C)-c1ccccc1
Show InChI InChI=1S/C29H28F2N4O2S/c1-15-10-22(26(17-8-6-5-7-9-17)34-25(15)24-14-32-16(2)38-24)33-28(37)35-27-18-11-20(30)21(31)12-19(18)29(3,4)13-23(27)36/h5-12,14,23,27,36H,13H2,1-4H3,(H2,33,35,37)/t23-,27+/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10669239 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%