Affinity Data by Patent

Patent code US10669243

Found 10 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Histone-lysine N-methyltransferase SMYD3 (Homo sapiens (Human))	BDBM321293 (5-cyclopropyl-N-((2R)-2-methyl-1- (vinylsulfonyl)p...) Show SMILES Show InChI	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	3.68E+3	n/a	n/a	n/a	n/a	n/a	n/a
EPIZYME, INC. US Patent					Assay Description The assays were an performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use. ...				US Patent US10669243 (2020)
EPIZYME, INC. US Patent					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3 (Homo sapiens (Human))	BDBM321292 (5-cyclopropyl-N-((2S)-2-methyl-1- (vinylsulfonyl)p...) Show SMILES Show InChI	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	5.28E+3	n/a	n/a	n/a	n/a	n/a	n/a
EPIZYME, INC. US Patent					Assay Description The assays were an performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use. ...				US Patent US10669243 (2020)
EPIZYME, INC. US Patent					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3 (Homo sapiens (Human))	BDBM321294 (5-cyclopropyl-N-((1s,4s)-4- (vinylsulfonamido)cycl...) Show SMILES Show InChI	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
EPIZYME, INC. US Patent					Assay Description The assays were an performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use. ...				US Patent US10669243 (2020)
EPIZYME, INC. US Patent					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3 (Homo sapiens (Human))	BDBM321287 (5-cyclopropyl-N-(1- (vinylsulfonyl)azetidin-3-yl) ...) Show SMILES Show InChI	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
EPIZYME, INC. US Patent					Assay Description The assays were an performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use. ...				US Patent US10669243 (2020)
EPIZYME, INC. US Patent					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3 (Homo sapiens (Human))	BDBM321288 (5-cyclopropyl-N-((1r,4r)-4- (vinylsulfonamido)cycl...) Show SMILES Show InChI	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	3.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
EPIZYME, INC. US Patent					Assay Description The assays were an performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use. ...				US Patent US10669243 (2020)
EPIZYME, INC. US Patent					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3 (Homo sapiens (Human))	BDBM321295 (5-cyclopropyl-N-(1- (vinylsulfonyl)piperidin-4-yl)...) Show SMILES Show InChI	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	3.17E+4	n/a	n/a	n/a	n/a	n/a	n/a
EPIZYME, INC. US Patent					Assay Description The assays were an performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use. ...				US Patent US10669243 (2020)
EPIZYME, INC. US Patent					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3 (Homo sapiens (Human))	BDBM321290 (N-(1-(2-chloroacetyl)piperidin-4-yl)-5- cyclopropy...) Show SMILES ClCC(=O)N1CCC(CC1)NC(=O)c1cc(on1)C1CC1 Show InChI	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	3.35E+4	n/a	n/a	n/a	n/a	n/a	n/a
EPIZYME, INC. US Patent					Assay Description The assays were an performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use. ...				US Patent US10669243 (2020)
EPIZYME, INC. US Patent					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3 (Homo sapiens (Human))	BDBM321296 (5-cyclopropyl-N-(1- (vinylsulfonyl)pyrrolidin-3-yl...) Show SMILES Show InChI	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
EPIZYME, INC. US Patent					Assay Description The assays were an performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use. ...				US Patent US10669243 (2020)
EPIZYME, INC. US Patent					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3 (Homo sapiens (Human))	BDBM321289 (N-((1r,4r)-4-acrylamidocyclohexyl)-5- cyclopropyli...) Show SMILES Show InChI	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	7.41E+4	n/a	n/a	n/a	n/a	n/a	n/a
EPIZYME, INC. US Patent					Assay Description The assays were an performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use. ...				US Patent US10669243 (2020)
EPIZYME, INC. US Patent					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3 (Homo sapiens (Human))	BDBM321291 (N-(1-acryloylpiperidin-4-yl)-5- cyclopropylisoxazo...) Show SMILES C=CC(=O)N1CCC(CC1)NC(=O)c1cc(on1)C1CC1 Show InChI	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
EPIZYME, INC. US Patent					Assay Description The assays were an performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use. ...				US Patent US10669243 (2020)
EPIZYME, INC. US Patent					More data for this Ligand-Target Pair

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* indicates data uncertainty>20%