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Patent code US10669246

Compile Data Set for Download or QSAR
Found 153 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445969
PNG
(US10669246, Example 22)
Show SMILES Cc1c(O)cccc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C18H15FN2O2S/c1-9-11(3-2-4-15(9)22)10-5-6-14-16(7-10)24-18(20-14)21-17(23)12-8-13(12)19/h2-7,12-13,22H,8H2,1H3,(H,20,21,23)/t12-,13+/m1/s1
PDB
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n/an/a 0.600n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445969
PNG
(US10669246, Example 22)
Show SMILES Cc1c(O)cccc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C18H15FN2O2S/c1-9-11(3-2-4-15(9)22)10-5-6-14-16(7-10)24-18(20-14)21-17(23)12-8-13(12)19/h2-7,12-13,22H,8H2,1H3,(H,20,21,23)/t12-,13+/m1/s1
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n/an/a 0.600n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446046
PNG
(US10669246, Example 97)
Show SMILES Cc1ccc(cc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1)-c1cc[nH]n1
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n/an/a 1.20n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445962
PNG
(US10669246, Example 14)
Show SMILES Cc1ccc(O)cc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C18H15FN2O2S/c1-9-2-4-11(22)7-12(9)10-3-5-15-16(6-10)24-18(20-15)21-17(23)13-8-14(13)19/h2-7,13-14,22H,8H2,1H3,(H,20,21,23)/t13-,14+/m1/s1
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n/an/a 1.30n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446026
PNG
(US10669246, Example 77)
Show SMILES Cc1ccc2[nH]ccc2c1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
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n/an/a 1.60n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446039
PNG
(US10669246, Example 90)
Show SMILES O=C(Nc1nc2ccc(cc2s1)-c1cnc2[nH]ccc2c1)C1CC1
Show InChI InChI=1S/C18H14N4OS/c23-17(10-1-2-10)22-18-21-14-4-3-11(8-15(14)24-18)13-7-12-5-6-19-16(12)20-9-13/h3-10H,1-2H2,(H,19,20)(H,21,22,23)
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n/an/a 1.60n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445962
PNG
(US10669246, Example 14)
Show SMILES Cc1ccc(O)cc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C18H15FN2O2S/c1-9-2-4-11(22)7-12(9)10-3-5-15-16(6-10)24-18(20-15)21-17(23)13-8-14(13)19/h2-7,13-14,22H,8H2,1H3,(H,20,21,23)/t13-,14+/m1/s1
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n/an/a 1.80n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446047
PNG
(US10669246, Example 98)
Show SMILES Cc1ccc2NC(=O)Cc2c1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C20H16FN3O2S/c1-9-2-4-14-12(8-17(25)22-14)18(9)10-3-5-15-16(6-10)27-20(23-15)24-19(26)11-7-13(11)21/h2-6,11,13H,7-8H2,1H3,(H,22,25)(H,23,24,26)/t11-,13+/m1/s1
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n/an/a 2.10n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445971
PNG
(US10669246, Example 24)
Show SMILES Cc1ccc2NCCc2c1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C20H18FN3OS/c1-10-2-4-15-12(6-7-22-15)18(10)11-3-5-16-17(8-11)26-20(23-16)24-19(25)13-9-14(13)21/h2-5,8,13-14,22H,6-7,9H2,1H3,(H,23,24,25)/t13-,14+/m1/s1
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n/an/a 2.30n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445971
PNG
(US10669246, Example 24)
Show SMILES Cc1ccc2NCCc2c1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C20H18FN3OS/c1-10-2-4-15-12(6-7-22-15)18(10)11-3-5-16-17(8-11)26-20(23-16)24-19(25)13-9-14(13)21/h2-5,8,13-14,22H,6-7,9H2,1H3,(H,23,24,25)/t13-,14+/m1/s1
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n/an/a 2.30n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446049
PNG
(US10669246, Example 100)
Show SMILES Cc1c[nH]c2ncc(cc12)-c1ccc2nc(NC(=O)C3CC3)sc2c1
Show InChI InChI=1S/C19H16N4OS/c1-10-8-20-17-14(10)6-13(9-21-17)12-4-5-15-16(7-12)25-19(22-15)23-18(24)11-2-3-11/h4-9,11H,2-3H2,1H3,(H,20,21)(H,22,23,24)
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n/an/a 2.5n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445996
PNG
(US10669246, Example 47)
Show SMILES Cc1c(F)cncc1-c1ccc2nc(NC(=O)C3CC3)sc2c1
Show InChI InChI=1S/C17H14FN3OS/c1-9-12(7-19-8-13(9)18)11-4-5-14-15(6-11)23-17(20-14)21-16(22)10-2-3-10/h4-8,10H,2-3H2,1H3,(H,20,21,22)
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n/an/a 2.5n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445956
PNG
(US10669246, Example 8)
Show SMILES Cc1c(F)cncc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C17H13F2N3OS/c1-8-11(6-20-7-13(8)19)9-2-3-14-15(4-9)24-17(21-14)22-16(23)10-5-12(10)18/h2-4,6-7,10,12H,5H2,1H3,(H,21,22,23)/t10-,12+/m1/s1
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n/an/a 2.70n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445956
PNG
(US10669246, Example 8)
Show SMILES Cc1c(F)cncc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C17H13F2N3OS/c1-8-11(6-20-7-13(8)19)9-2-3-14-15(4-9)24-17(21-14)22-16(23)10-5-12(10)18/h2-4,6-7,10,12H,5H2,1H3,(H,21,22,23)/t10-,12+/m1/s1
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n/an/a 2.70n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446060
PNG
(US10669246, Example 111)
Show SMILES Cc1ccc2ncsc2c1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C19H14FN3OS2/c1-9-2-4-14-17(25-8-21-14)16(9)10-3-5-13-15(6-10)26-19(22-13)23-18(24)11-7-12(11)20/h2-6,8,11-12H,7H2,1H3,(H,22,23,24)/t11-,12+/m1/s1
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n/an/a 3n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446050
PNG
(US10669246, Example 101)
Show SMILES F[C@H]1CC1C(=O)Nc1nc2ccc(cc2s1)-c1cnc2[nH]ccc2c1
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n/an/a 3.20n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446034
PNG
(US10669246, Example 85)
Show SMILES Cc1ccc(cc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1)C#C
Show InChI InChI=1S/C20H15FN2OS/c1-3-12-5-4-11(2)14(8-12)13-6-7-17-18(9-13)25-20(22-17)23-19(24)15-10-16(15)21/h1,4-9,15-16H,10H2,2H3,(H,22,23,24)/t15-,16+/m1/s1
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n/an/a 3.60n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446057
PNG
(US10669246, Example 108)
Show SMILES Cc1c(ccc2cn[nH]c12)-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
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n/an/a 3.80n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445970
PNG
(US10669246, Example 23)
Show SMILES Cc1cc(N)nc(C)c1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C18H17FN4OS/c1-8-5-15(20)21-9(2)16(8)10-3-4-13-14(6-10)25-18(22-13)23-17(24)11-7-12(11)19/h3-6,11-12H,7H2,1-2H3,(H2,20,21)(H,22,23,24)/t11-,12+/m1/s1
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n/an/a 4n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445952
PNG
(US10669246, Example 4)
Show SMILES Cc1ccncc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C17H14FN3OS/c1-9-4-5-19-8-12(9)10-2-3-14-15(6-10)23-17(20-14)21-16(22)11-7-13(11)18/h2-6,8,11,13H,7H2,1H3,(H,20,21,22)/t11-,13+/m1/s1
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n/an/a 4.10n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445952
PNG
(US10669246, Example 4)
Show SMILES Cc1ccncc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C17H14FN3OS/c1-9-4-5-19-8-12(9)10-2-3-14-15(6-10)23-17(20-14)21-16(22)11-7-13(11)18/h2-6,8,11,13H,7H2,1H3,(H,20,21,22)/t11-,13+/m1/s1
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n/an/a 4.10n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446027
PNG
(US10669246, Example 78)
Show SMILES Cc1cccc(F)c1-c1ccc2nc(NC(=O)C3CC3)sc2c1
Show InChI InChI=1S/C18H15FN2OS/c1-10-3-2-4-13(19)16(10)12-7-8-14-15(9-12)23-18(20-14)21-17(22)11-5-6-11/h2-4,7-9,11H,5-6H2,1H3,(H,20,21,22)
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n/an/a 4.20n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446051
PNG
(US10669246, Example 102)
Show SMILES O=C(Nc1nc2ccc(cc2s1)-c1cnc2[nH]ncc2c1)C1CC1
Show InChI InChI=1S/C17H13N5OS/c23-16(9-1-2-9)21-17-20-13-4-3-10(6-14(13)24-17)11-5-12-8-19-22-15(12)18-7-11/h3-9H,1-2H2,(H,18,19,22)(H,20,21,23)
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n/an/a 5.10n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446037
PNG
(US10669246, Example 88)
Show SMILES Cc1ccnc(F)c1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C17H13F2N3OS/c1-8-4-5-20-15(19)14(8)9-2-3-12-13(6-9)24-17(21-12)22-16(23)10-7-11(10)18/h2-6,10-11H,7H2,1H3,(H,21,22,23)/t10-,11+/m1/s1
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n/an/a 5.10n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446004
PNG
(US10669246, Example 55)
Show SMILES COc1ccncc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C17H14FN3O2S/c1-23-14-4-5-19-8-11(14)9-2-3-13-15(6-9)24-17(20-13)21-16(22)10-7-12(10)18/h2-6,8,10,12H,7H2,1H3,(H,20,21,22)/t10-,12+/m1/s1
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n/an/a 5.90n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446042
PNG
(US10669246, Example 93)
Show SMILES Cc1ccc(cc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1)C#N
Show InChI InChI=1S/C19H14FN3OS/c1-10-2-3-11(9-21)6-13(10)12-4-5-16-17(7-12)25-19(22-16)23-18(24)14-8-15(14)20/h2-7,14-15H,8H2,1H3,(H,22,23,24)/t14-,15+/m1/s1
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n/an/a 7.10n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446035
PNG
(US10669246, Example 86)
Show SMILES F[C@H]1C[C@H]1C(=O)Nc1nc2ccc(cc2s1)-c1cnccc1Cl
Show InChI InChI=1S/C16H11ClFN3OS/c17-11-3-4-19-7-10(11)8-1-2-13-14(5-8)23-16(20-13)21-15(22)9-6-12(9)18/h1-5,7,9,12H,6H2,(H,20,21,22)/t9-,12+/m1/s1
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n/an/a 7.40n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445966
PNG
(US10669246, Example 19)
Show SMILES Nc1ccc(cn1)-c1ccc2nc(NC(=O)C3CC3)sc2c1
Show InChI InChI=1S/C16H14N4OS/c17-14-6-4-11(8-18-14)10-3-5-12-13(7-10)22-16(19-12)20-15(21)9-1-2-9/h3-9H,1-2H2,(H2,17,18)(H,19,20,21)
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n/an/a 7.40n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446059
PNG
(US10669246, Example 110)
Show SMILES Cc1ccc(cc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1)-c1ncc[nH]1
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n/an/a 7.70n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445964
PNG
(US10669246, Example 17)
Show SMILES CC(=C)c1ccc(C)c(c1)-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C21H19FN2OS/c1-11(2)13-5-4-12(3)15(8-13)14-6-7-18-19(9-14)26-21(23-18)24-20(25)16-10-17(16)22/h4-9,16-17H,1,10H2,2-3H3,(H,23,24,25)/t16-,17+/m1/s1
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n/an/a 7.80n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445964
PNG
(US10669246, Example 17)
Show SMILES CC(=C)c1ccc(C)c(c1)-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C21H19FN2OS/c1-11(2)13-5-4-12(3)15(8-13)14-6-7-18-19(9-14)26-21(23-18)24-20(25)16-10-17(16)22/h4-9,16-17H,1,10H2,2-3H3,(H,23,24,25)/t16-,17+/m1/s1
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n/an/a 7.80n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446005
PNG
(US10669246, Example 56)
Show SMILES Cc1ccsc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C16H13FN2OS2/c1-8-4-5-21-14(8)9-2-3-12-13(6-9)22-16(18-12)19-15(20)10-7-11(10)17/h2-6,10-11H,7H2,1H3,(H,18,19,20)/t10-,11+/m1/s1
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n/an/a 7.90n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445997
PNG
(US10669246, Example 48)
Show SMILES Cc1c(F)cncc1-c1ccc2nc(NC(=O)C3CC3(F)F)sc2c1
Show InChI InChI=1S/C17H12F3N3OS/c1-8-10(6-21-7-12(8)18)9-2-3-13-14(4-9)25-16(22-13)23-15(24)11-5-17(11,19)20/h2-4,6-7,11H,5H2,1H3,(H,22,23,24)
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n/an/a 7.90n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445959
PNG
(US10669246, Example 11)
Show SMILES Cc1ccnc(Cl)c1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C17H13ClFN3OS/c1-8-4-5-20-15(18)14(8)9-2-3-12-13(6-9)24-17(21-12)22-16(23)10-7-11(10)19/h2-6,10-11H,7H2,1H3,(H,21,22,23)/t10-,11+/m1/s1
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n/an/a 8.30n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446024
PNG
(US10669246, Example 75)
Show SMILES Cc1ccc(cc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1)-n1cccn1
Show InChI InChI=1S/C21H17FN4OS/c1-12-3-5-14(26-8-2-7-23-26)10-15(12)13-4-6-18-19(9-13)28-21(24-18)25-20(27)16-11-17(16)22/h2-10,16-17H,11H2,1H3,(H,24,25,27)/t16-,17+/m1/s1
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n/an/a 8.30n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445959
PNG
(US10669246, Example 11)
Show SMILES Cc1ccnc(Cl)c1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C17H13ClFN3OS/c1-8-4-5-20-15(18)14(8)9-2-3-12-13(6-9)24-17(21-12)22-16(23)10-7-11(10)19/h2-6,10-11H,7H2,1H3,(H,21,22,23)/t10-,11+/m1/s1
PDB
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n/an/a 8.30n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445953
PNG
(US10669246, Example 5)
Show SMILES Cc1ccncc1-c1ccc2nc(NC(=O)C3CC3)sc2c1
Show InChI InChI=1S/C17H15N3OS/c1-10-6-7-18-9-13(10)12-4-5-14-15(8-12)22-17(19-14)20-16(21)11-2-3-11/h4-9,11H,2-3H2,1H3,(H,19,20,21)
PDB
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n/an/a 9n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445953
PNG
(US10669246, Example 5)
Show SMILES Cc1ccncc1-c1ccc2nc(NC(=O)C3CC3)sc2c1
Show InChI InChI=1S/C17H15N3OS/c1-10-6-7-18-9-13(10)12-4-5-14-15(8-12)22-17(19-14)20-16(21)11-2-3-11/h4-9,11H,2-3H2,1H3,(H,19,20,21)
PDB
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n/an/a 9n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446041
PNG
(US10669246, Example 92)
Show SMILES Cc1ccc(cc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1)-c1nccs1
Show InChI InChI=1S/C21H16FN3OS2/c1-11-2-3-13(20-23-6-7-27-20)8-14(11)12-4-5-17-18(9-12)28-21(24-17)25-19(26)15-10-16(15)22/h2-9,15-16H,10H2,1H3,(H,24,25,26)/t15-,16+/m1/s1
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n/an/a 9.30n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446040
PNG
(US10669246, Example 91)
Show SMILES Cc1ccc(cc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1)-c1cc[nH]c1
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n/an/a 9.90n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446045
PNG
(US10669246, Example 96)
Show SMILES Cc1ccc(cc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1)-c1ccc[nH]1
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n/an/a 10.1n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445983
PNG
(US10669246, Example 36)
Show SMILES Cc1ccncc1-c1ccc2nc(NC(=O)C3CC3(F)F)sc2c1
Show InChI InChI=1S/C17H13F2N3OS/c1-9-4-5-20-8-11(9)10-2-3-13-14(6-10)24-16(21-13)22-15(23)12-7-17(12,18)19/h2-6,8,12H,7H2,1H3,(H,21,22,23)
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n/an/a 11.4n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445983
PNG
(US10669246, Example 36)
Show SMILES Cc1ccncc1-c1ccc2nc(NC(=O)C3CC3(F)F)sc2c1
Show InChI InChI=1S/C17H13F2N3OS/c1-9-4-5-20-8-11(9)10-2-3-13-14(6-10)24-16(21-13)22-15(23)12-7-17(12,18)19/h2-6,8,12H,7H2,1H3,(H,21,22,23)
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n/an/a 11.4n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446054
PNG
(US10669246, Example 105)
Show SMILES Cc1cc(sn1)-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C15H12FN3OS2/c1-7-4-12(22-19-7)8-2-3-11-13(5-8)21-15(17-11)18-14(20)9-6-10(9)16/h2-5,9-10H,6H2,1H3,(H,17,18,20)/t9-,10+/m1/s1
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n/an/a 11.5n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445998
PNG
(US10669246, Example 49)
Show SMILES Cc1c(F)cncc1-c1ccc2nc(NC(=O)C3CCC3)sc2c1
Show InChI InChI=1S/C18H16FN3OS/c1-10-13(8-20-9-14(10)19)12-5-6-15-16(7-12)24-18(21-15)22-17(23)11-3-2-4-11/h5-9,11H,2-4H2,1H3,(H,21,22,23)
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n/an/a 11.6n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445951
PNG
(US10669246, Example 3)
Show SMILES Cc1cccc(C)c1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C19H17FN2OS/c1-10-4-3-5-11(2)17(10)12-6-7-15-16(8-12)24-19(21-15)22-18(23)13-9-14(13)20/h3-8,13-14H,9H2,1-2H3,(H,21,22,23)/t13-,14+/m1/s1
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n/an/a 11.9n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445951
PNG
(US10669246, Example 3)
Show SMILES Cc1cccc(C)c1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C19H17FN2OS/c1-10-4-3-5-11(2)17(10)12-6-7-15-16(8-12)24-19(21-15)22-18(23)13-9-14(13)20/h3-8,13-14H,9H2,1-2H3,(H,21,22,23)/t13-,14+/m1/s1
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n/an/a 11.9n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446064
PNG
(US10669246, Example 121)
Show SMILES Cc1ccncc1-c1ccc2nc(NC(=O)[C@H]3C[C@H]3F)sc2c1
Show InChI InChI=1S/C17H14FN3OS/c1-9-4-5-19-8-12(9)10-2-3-14-15(6-10)23-17(20-14)21-16(22)11-7-13(11)18/h2-6,8,11,13H,7H2,1H3,(H,20,21,22)/t11-,13+/m0/s1
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n/an/a 12.7n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446063
PNG
(US10669246, Example 120)
Show SMILES Cc1cc(F)ncc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C17H13F2N3OS/c1-8-4-15(19)20-7-11(8)9-2-3-13-14(5-9)24-17(21-13)22-16(23)10-6-12(10)18/h2-5,7,10,12H,6H2,1H3,(H,21,22,23)/t10-,12+/m1/s1
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n/an/a 13.3n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446058
PNG
(US10669246, Example 109)
Show SMILES Cc1nsc(c1C)-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C16H14FN3OS2/c1-7-8(2)20-23-14(7)9-3-4-12-13(5-9)22-16(18-12)19-15(21)10-6-11(10)17/h3-5,10-11H,6H2,1-2H3,(H,18,19,21)/t10-,11+/m1/s1
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n/an/a 13.7n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446056
PNG
(US10669246, Example 107)
Show SMILES Cc1ccc(-c2ccc3nc(NC(=O)[C@@H]4C[C@@H]4F)sc3c2)c2cn[nH]c12
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n/an/a 14.8n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445995
PNG
(US10669246, Example 46)
Show SMILES CNc1ccc(C)c(-c2ccc3nc(NC(=O)[C@@H]4C[C@@H]4F)sc3c2)c1F
Show InChI InChI=1S/C19H17F2N3OS/c1-9-3-5-14(22-2)17(21)16(9)10-4-6-13-15(7-10)26-19(23-13)24-18(25)11-8-12(11)20/h3-7,11-12,22H,8H2,1-2H3,(H,23,24,25)/t11-,12+/m1/s1
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n/an/a 16.8n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446013
PNG
(US10669246, Example 64)
Show SMILES Cc1c(F)cncc1-c1ccc2nc(NC(=O)C3C[C@H]3CO)sc2c1
Show InChI InChI=1S/C18H16FN3O2S/c1-9-13(6-20-7-14(9)19)10-2-3-15-16(5-10)25-18(21-15)22-17(24)12-4-11(12)8-23/h2-3,5-7,11-12,23H,4,8H2,1H3,(H,21,22,24)/t11-,12?/m0/s1
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n/an/a 17n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446017
PNG
(US10669246, Example 68)
Show SMILES OCc1ccncc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C17H14FN3O2S/c18-13-6-11(13)16(23)21-17-20-14-2-1-9(5-15(14)24-17)12-7-19-4-3-10(12)8-22/h1-5,7,11,13,22H,6,8H2,(H,20,21,23)/t11-,13+/m1/s1
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n/an/a 17.8n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445949
PNG
(US10669246, Example 1)
Show SMILES Cc1cccc(F)c1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C18H14F2N2OS/c1-9-3-2-4-12(19)16(9)10-5-6-14-15(7-10)24-18(21-14)22-17(23)11-8-13(11)20/h2-7,11,13H,8H2,1H3,(H,21,22,23)/t11-,13+/m1/s1
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n/an/a 18.4n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445949
PNG
(US10669246, Example 1)
Show SMILES Cc1cccc(F)c1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C18H14F2N2OS/c1-9-3-2-4-12(19)16(9)10-5-6-14-15(7-10)24-18(21-14)22-17(23)11-8-13(11)20/h2-7,11,13H,8H2,1H3,(H,21,22,23)/t11-,13+/m1/s1
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n/an/a 18.4n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446033
PNG
(US10669246, Example 84)
Show SMILES Cc1c2NC(=O)Cc2ccc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C20H16FN3O2S/c1-9-12(4-2-11-7-17(25)23-18(9)11)10-3-5-15-16(6-10)27-20(22-15)24-19(26)13-8-14(13)21/h2-6,13-14H,7-8H2,1H3,(H,23,25)(H,22,24,26)/t13-,14+/m1/s1
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n/an/a 18.8n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446011
PNG
(US10669246, Example 62)
Show SMILES CC(=O)c1cc(C)c(cn1)-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C19H16FN3O2S/c1-9-5-16(10(2)24)21-8-13(9)11-3-4-15-17(6-11)26-19(22-15)23-18(25)12-7-14(12)20/h3-6,8,12,14H,7H2,1-2H3,(H,22,23,25)/t12-,14+/m1/s1
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n/an/a 19.9n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446028
PNG
(US10669246, Example 79)
Show SMILES Cc1c(CO)cncc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C18H16FN3O2S/c1-9-11(8-23)6-20-7-13(9)10-2-3-15-16(4-10)25-18(21-15)22-17(24)12-5-14(12)19/h2-4,6-7,12,14,23H,5,8H2,1H3,(H,21,22,24)/t12-,14+/m1/s1
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n/an/a 20n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446052
PNG
(US10669246, Example 103)
Show SMILES O=C(Nc1nc2ccc(cc2s1)-c1cnc2NC(=O)Cc2c1)C1CC1
Show InChI InChI=1S/C18H14N4O2S/c23-15-7-11-5-12(8-19-16(11)21-15)10-3-4-13-14(6-10)25-18(20-13)22-17(24)9-1-2-9/h3-6,8-9H,1-2,7H2,(H,19,21,23)(H,20,22,24)
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n/an/a 20.3n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446015
PNG
(US10669246, Example 66)
Show SMILES Cc1cc(Cl)ncc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C17H13ClFN3OS/c1-8-4-15(18)20-7-11(8)9-2-3-13-14(5-9)24-17(21-13)22-16(23)10-6-12(10)19/h2-5,7,10,12H,6H2,1H3,(H,21,22,23)/t10-,12+/m1/s1
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n/an/a 20.3n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446053
PNG
(US10669246, Example 104)
Show SMILES O=C(Nc1nc2ccc(cc2s1)-c1cnc2NCCc2c1)C1CC1
Show InChI InChI=1S/C18H16N4OS/c23-17(10-1-2-10)22-18-21-14-4-3-11(8-15(14)24-18)13-7-12-5-6-19-16(12)20-9-13/h3-4,7-10H,1-2,5-6H2,(H,19,20)(H,21,22,23)
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n/an/a 21n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446044
PNG
(US10669246, Example 95)
Show SMILES Cc1c[nH]nc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
PDB
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n/an/a 21.1n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446062
PNG
(US10669246, Example 113)
Show SMILES Cc1cc(CF)ncc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C18H15F2N3OS/c1-9-4-11(7-19)21-8-13(9)10-2-3-15-16(5-10)25-18(22-15)23-17(24)12-6-14(12)20/h2-5,8,12,14H,6-7H2,1H3,(H,22,23,24)/t12-,14+/m1/s1
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n/an/a 21.2n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446014
PNG
(US10669246, Example 65)
Show SMILES Cc1cc(C)c(cn1)-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C18H16FN3OS/c1-9-5-10(2)20-8-13(9)11-3-4-15-16(6-11)24-18(21-15)22-17(23)12-7-14(12)19/h3-6,8,12,14H,7H2,1-2H3,(H,21,22,23)/t12-,14+/m1/s1
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n/an/a 21.3n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445958
PNG
(US10669246, Example 10)
Show SMILES CC(=O)Nc1ccc(C)c(c1)-c1ccc2nc(NC(=O)C3CC3)sc2c1
Show InChI InChI=1S/C20H19N3O2S/c1-11-3-7-15(21-12(2)24)10-16(11)14-6-8-17-18(9-14)26-20(22-17)23-19(25)13-4-5-13/h3,6-10,13H,4-5H2,1-2H3,(H,21,24)(H,22,23,25)
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n/an/a 22.6n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445958
PNG
(US10669246, Example 10)
Show SMILES CC(=O)Nc1ccc(C)c(c1)-c1ccc2nc(NC(=O)C3CC3)sc2c1
Show InChI InChI=1S/C20H19N3O2S/c1-11-3-7-15(21-12(2)24)10-16(11)14-6-8-17-18(9-14)26-20(22-17)23-19(25)13-4-5-13/h3,6-10,13H,4-5H2,1-2H3,(H,21,24)(H,22,23,25)
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n/an/a 22.6n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446065
PNG
(US10669246, Example 122)
Show SMILES Cc1ccncc1-c1ccc2nc(NC(=O)[C@@H]3C[C@H]3F)sc2c1
Show InChI InChI=1S/C17H14FN3OS/c1-9-4-5-19-8-12(9)10-2-3-14-15(6-10)23-17(20-14)21-16(22)11-7-13(11)18/h2-6,8,11,13H,7H2,1H3,(H,20,21,22)/t11-,13-/m1/s1
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n/an/a 23.7n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445999
PNG
(US10669246, Example 50)
Show SMILES Cc1c(F)cncc1-c1ccc2nc(NC(=O)C3CC(F)C3)sc2c1
Show InChI InChI=1S/C18H15F2N3OS/c1-9-13(7-21-8-14(9)20)10-2-3-15-16(6-10)25-18(22-15)23-17(24)11-4-12(19)5-11/h2-3,6-8,11-12H,4-5H2,1H3,(H,22,23,24)
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n/an/a 24.4n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446019
PNG
(US10669246, Example 70)
Show SMILES CC(O)c1cc(C)c(cn1)-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C19H18FN3O2S/c1-9-5-16(10(2)24)21-8-13(9)11-3-4-15-17(6-11)26-19(22-15)23-18(25)12-7-14(12)20/h3-6,8,10,12,14,24H,7H2,1-2H3,(H,22,23,25)/t10?,12-,14+/m1/s1
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n/an/a 24.6n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446018
PNG
(US10669246, Example 69)
Show SMILES Cc1cc(CO)ncc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C18H16FN3O2S/c1-9-4-11(8-23)20-7-13(9)10-2-3-15-16(5-10)25-18(21-15)22-17(24)12-6-14(12)19/h2-5,7,12,14,23H,6,8H2,1H3,(H,21,22,24)/t12-,14+/m1/s1
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n/an/a 25.4n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445988
PNG
(US10669246, Example 39)
Show SMILES Cc1cccc(F)c1-c1ccc2nc(NC(=O)C3CC3(F)F)sc2c1
Show InChI InChI=1S/C18H13F3N2OS/c1-9-3-2-4-12(19)15(9)10-5-6-13-14(7-10)25-17(22-13)23-16(24)11-8-18(11,20)21/h2-7,11H,8H2,1H3,(H,22,23,24)
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n/an/a 27.5n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445950
PNG
(US10669246, Example 2)
Show SMILES Cc1cccc(Cl)c1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C18H14ClFN2OS/c1-9-3-2-4-12(19)16(9)10-5-6-14-15(7-10)24-18(21-14)22-17(23)11-8-13(11)20/h2-7,11,13H,8H2,1H3,(H,21,22,23)/t11-,13+/m1/s1
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n/an/a 29.8n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445950
PNG
(US10669246, Example 2)
Show SMILES Cc1cccc(Cl)c1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C18H14ClFN2OS/c1-9-3-2-4-12(19)16(9)10-5-6-14-15(7-10)24-18(21-14)22-17(23)11-8-13(11)20/h2-7,11,13H,8H2,1H3,(H,21,22,23)/t11-,13+/m1/s1
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n/an/a 29.8n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445960
PNG
(US10669246, Example 12)
Show SMILES Cc1ccnc(C)c1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C18H16FN3OS/c1-9-5-6-20-10(2)16(9)11-3-4-14-15(7-11)24-18(21-14)22-17(23)12-8-13(12)19/h3-7,12-13H,8H2,1-2H3,(H,21,22,23)/t12-,13+/m1/s1
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n/an/a 32.3n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445960
PNG
(US10669246, Example 12)
Show SMILES Cc1ccnc(C)c1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C18H16FN3OS/c1-9-5-6-20-10(2)16(9)11-3-4-14-15(7-11)24-18(21-14)22-17(23)12-8-13(12)19/h3-7,12-13H,8H2,1-2H3,(H,21,22,23)/t12-,13+/m1/s1
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n/an/a 32.3n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445957
PNG
(US10669246, Example 9)
Show SMILES Cc1ccncc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3CO)sc2c1
Show InChI InChI=1S/C18H17N3O2S/c1-10-4-5-19-8-14(10)11-2-3-15-16(7-11)24-18(20-15)21-17(23)13-6-12(13)9-22/h2-5,7-8,12-13,22H,6,9H2,1H3,(H,20,21,23)/t12-,13-/m1/s1
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n/an/a 34.6n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445957
PNG
(US10669246, Example 9)
Show SMILES Cc1ccncc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3CO)sc2c1
Show InChI InChI=1S/C18H17N3O2S/c1-10-4-5-19-8-14(10)11-2-3-15-16(7-11)24-18(20-15)21-17(23)13-6-12(13)9-22/h2-5,7-8,12-13,22H,6,9H2,1H3,(H,20,21,23)/t12-,13-/m1/s1
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n/an/a 34.6n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446000
PNG
(US10669246, Example 51)
Show SMILES Cc1c(F)cncc1-c1ccc2nc(NC(=O)C3CC(F)(F)C3)sc2c1
Show InChI InChI=1S/C18H14F3N3OS/c1-9-12(7-22-8-13(9)19)10-2-3-14-15(4-10)26-17(23-14)24-16(25)11-5-18(20,21)6-11/h2-4,7-8,11H,5-6H2,1H3,(H,23,24,25)
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n/an/a 35.7n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446008
PNG
(US10669246, Example 59)
Show SMILES Cc1cccc(F)c1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3CO)sc2c1
Show InChI InChI=1S/C19H17FN2O2S/c1-10-3-2-4-14(20)17(10)11-5-6-15-16(8-11)25-19(21-15)22-18(24)13-7-12(13)9-23/h2-6,8,12-13,23H,7,9H2,1H3,(H,21,22,24)/t12-,13-/m1/s1
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n/an/a 38.8n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446029
PNG
(US10669246, Example 80)
Show SMILES Cc1ccncc1-c1cc(F)c2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C17H13F2N3OS/c1-8-2-3-20-7-11(8)9-4-13(19)15-14(5-9)24-17(21-15)22-16(23)10-6-12(10)18/h2-5,7,10,12H,6H2,1H3,(H,21,22,23)/t10-,12+/m1/s1
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n/an/a 39.3n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446031
PNG
(US10669246, Example 82)
Show SMILES Cc1scnc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C15H12FN3OS2/c1-7-13(17-6-21-7)8-2-3-11-12(4-8)22-15(18-11)19-14(20)9-5-10(9)16/h2-4,6,9-10H,5H2,1H3,(H,18,19,20)/t9-,10+/m1/s1
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n/an/a 40.4n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445979
PNG
(US10669246, Example 32)
Show SMILES CC(=O)N1CCc2c1ccc(C)c2-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C22H20FN3O2S/c1-11-3-6-18-14(7-8-26(18)12(2)27)20(11)13-4-5-17-19(9-13)29-22(24-17)25-21(28)15-10-16(15)23/h3-6,9,15-16H,7-8,10H2,1-2H3,(H,24,25,28)/t15-,16+/m1/s1
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n/an/a 47.2n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446010
PNG
(US10669246, Example 61)
Show SMILES Cc1ncncc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C16H13FN4OS/c1-8-11(6-18-7-19-8)9-2-3-13-14(4-9)23-16(20-13)21-15(22)10-5-12(10)17/h2-4,6-7,10,12H,5H2,1H3,(H,20,21,22)/t10-,12+/m1/s1
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n/an/a 50.1n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446036
PNG
(US10669246, Example 87)
Show SMILES F[C@H]1C[C@H]1C(=O)Nc1nc2ccc(cc2s1)-c1cnccc1C#N
Show InChI InChI=1S/C17H11FN4OS/c18-13-6-11(13)16(23)22-17-21-14-2-1-9(5-15(14)24-17)12-8-20-4-3-10(12)7-19/h1-5,8,11,13H,6H2,(H,21,22,23)/t11-,13+/m1/s1
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n/an/a 50.9n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445992
PNG
(US10669246, Example 43)
Show SMILES Cc1ccncc1-c1ccc2nc(NC(=O)C3CCC3)sc2c1
Show InChI InChI=1S/C18H17N3OS/c1-11-7-8-19-10-14(11)13-5-6-15-16(9-13)23-18(20-15)21-17(22)12-3-2-4-12/h5-10,12H,2-4H2,1H3,(H,20,21,22)
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n/an/a 56.4n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446022
PNG
(US10669246, Example 73)
Show SMILES F[C@H]1C[C@H]1C(=O)Nc1nc2ccc(cc2s1)-c1cc[nH]n1
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n/an/a 57.6n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446012
PNG
(US10669246, Example 63)
Show SMILES Cc1cccc(F)c1-c1ccc2nc(NC(=O)C3C[C@H]3CO)sc2c1
Show InChI InChI=1S/C19H17FN2O2S/c1-10-3-2-4-14(20)17(10)11-5-6-15-16(8-11)25-19(21-15)22-18(24)13-7-12(13)9-23/h2-6,8,12-13,23H,7,9H2,1H3,(H,21,22,24)/t12-,13?/m0/s1
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n/an/a 58.2n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446021
PNG
(US10669246, Example 72)
Show SMILES F[C@H]1C[C@H]1C(=O)Nc1nc2ccc(cc2s1)-c1cnccc1C(F)(F)F
Show InChI InChI=1S/C17H11F4N3OS/c18-12-6-9(12)15(25)24-16-23-13-2-1-8(5-14(13)26-16)10-7-22-4-3-11(10)17(19,20)21/h1-5,7,9,12H,6H2,(H,23,24,25)/t9-,12+/m1/s1
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n/an/a 63.5n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446006
PNG
(US10669246, Example 57)
Show SMILES CC1=C(C=[N]([O-])C=C1)c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C17H14FN3O2S/c1-9-4-5-21(23)8-12(9)10-2-3-14-15(6-10)24-17(19-14)20-16(22)11-7-13(11)18/h2-6,8,11,13H,7H2,1H3,(H-,19,20,22,23)/q-1/t11-,13+/m1/s1
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n/an/a 74.2n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445986
PNG
(US10669246, Example 37)
Show SMILES Cc1ccncc1-c1ccc2nc(NC(=O)C3C[C@H](F)C3)sc2c1
Show InChI InChI=1S/C18H16FN3OS/c1-10-4-5-20-9-14(10)11-2-3-15-16(8-11)24-18(21-15)22-17(23)12-6-13(19)7-12/h2-5,8-9,12-13H,6-7H2,1H3,(H,21,22,23)/t12?,13-
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n/an/a 76.2n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446032
PNG
(US10669246, Example 83)
Show SMILES Cc1ncnc(C)c1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C17H15FN4OS/c1-8-15(9(2)20-7-19-8)10-3-4-13-14(5-10)24-17(21-13)22-16(23)11-6-12(11)18/h3-5,7,11-12H,6H2,1-2H3,(H,21,22,23)/t11-,12+/m1/s1
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n/an/a 90.6n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446048
PNG
(US10669246, Example 99)
Show SMILES Cc1c(ccc2sc(=O)[nH]c12)-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
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n/an/a 103n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445987
PNG
(US10669246, Example 38)
Show SMILES Cc1ccncc1-c1ccc2nc(NC(=O)C3C[C@H](F)C3)sc2c1
Show InChI InChI=1S/C18H16FN3OS/c1-10-4-5-20-9-14(10)11-2-3-15-16(8-11)24-18(21-15)22-17(23)12-6-13(19)7-12/h2-5,8-9,12-13H,6-7H2,1H3,(H,21,22,23)/t12?,13-
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n/an/a 103n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445963
PNG
(US10669246, Example 15)
Show SMILES Cc1ccc(cc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1)C(C)(C)O
Show InChI InChI=1S/C21H21FN2O2S/c1-11-4-6-13(21(2,3)26)9-14(11)12-5-7-17-18(8-12)27-20(23-17)24-19(25)15-10-16(15)22/h4-9,15-16,26H,10H2,1-3H3,(H,23,24,25)/t15-,16+/m1/s1
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n/an/a 116n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446055
PNG
(US10669246, Example 106)
Show SMILES Cc1nsc(c1Cl)-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C15H11ClFN3OS2/c1-6-12(16)13(23-20-6)7-2-3-10-11(4-7)22-15(18-10)19-14(21)8-5-9(8)17/h2-4,8-9H,5H2,1H3,(H,18,19,21)/t8-,9+/m1/s1
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n/an/a 116n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446038
PNG
(US10669246, Example 89)
Show SMILES F[C@H]1C[C@H]1C(=O)Nc1nc2ccc(cc2s1)-c1cncnc1C(F)(F)F
Show InChI InChI=1S/C16H10F4N4OS/c17-10-4-8(10)14(25)24-15-23-11-2-1-7(3-12(11)26-15)9-5-21-6-22-13(9)16(18,19)20/h1-3,5-6,8,10H,4H2,(H,23,24,25)/t8-,10+/m1/s1
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n/an/a 120n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446009
PNG
(US10669246, Example 60)
Show SMILES Cc1cccc(F)c1-c1ccc2nc(NC(=O)[C@H]3C[C@H]3CO)sc2c1
Show InChI InChI=1S/C19H17FN2O2S/c1-10-3-2-4-14(20)17(10)11-5-6-15-16(8-11)25-19(21-15)22-18(24)13-7-12(13)9-23/h2-6,8,12-13,23H,7,9H2,1H3,(H,21,22,24)/t12-,13-/m0/s1
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n/an/a 128n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446007
PNG
(US10669246, Example 58)
Show SMILES OB(O)c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C11H10BFN2O3S/c13-7-4-6(7)10(16)15-11-14-8-2-1-5(12(17)18)3-9(8)19-11/h1-3,6-7,17-18H,4H2,(H,14,15,16)/t6-,7+/m1/s1
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n/an/a 131n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446030
PNG
(US10669246, Example 81)
Show SMILES Cc1cccc(F)c1-c1cc(F)c2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C18H13F3N2OS/c1-8-3-2-4-11(19)15(8)9-5-13(21)16-14(6-9)25-18(22-16)23-17(24)10-7-12(10)20/h2-6,10,12H,7H2,1H3,(H,22,23,24)/t10-,12+/m1/s1
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n/an/a 142n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Homo sapiens (Human))
BDBM445962
PNG
(US10669246, Example 14)
Show SMILES Cc1ccc(O)cc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C18H15FN2O2S/c1-9-2-4-11(22)7-12(9)10-3-5-15-16(6-10)24-18(20-15)21-17(23)13-8-14(13)19/h2-7,13-14,22H,8H2,1H3,(H,20,21,23)/t13-,14+/m1/s1
PDB

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n/an/a 143n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), Bovine serum albumin (BSA) and dimethylsulfoxide (DMSO) were purchased from...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445993
PNG
(US10669246, Example 44)
Show SMILES Cc1ccncc1-c1ccc2nc(NC(=O)C3CC(F)(F)C3)sc2c1
Show InChI InChI=1S/C18H15F2N3OS/c1-10-4-5-21-9-13(10)11-2-3-14-15(6-11)25-17(22-14)23-16(24)12-7-18(19,20)8-12/h2-6,9,12H,7-8H2,1H3,(H,22,23,24)
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n/an/a 161n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446023
PNG
(US10669246, Example 74)
Show SMILES Cc1ccc(cc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1)C#Cc1ccccn1
Show InChI InChI=1S/C25H18FN3OS/c1-15-5-6-16(7-9-18-4-2-3-11-27-18)12-19(15)17-8-10-22-23(13-17)31-25(28-22)29-24(30)20-14-21(20)26/h2-6,8,10-13,20-21H,14H2,1H3,(H,28,29,30)/t20-,21+/m1/s1
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n/an/a 172n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Homo sapiens (Human))
BDBM445969
PNG
(US10669246, Example 22)
Show SMILES Cc1c(O)cccc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C18H15FN2O2S/c1-9-11(3-2-4-15(9)22)10-5-6-14-16(7-10)24-18(20-14)21-17(23)12-8-13(12)19/h2-7,12-13,22H,8H2,1H3,(H,20,21,23)/t12-,13+/m1/s1
PDB

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n/an/a 177n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), Bovine serum albumin (BSA) and dimethylsulfoxide (DMSO) were purchased from...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445989
PNG
(US10669246, Example 40)
Show SMILES Cc1cccc(F)c1-c1ccc2nc(NC(=O)[C@@H]3C[C@H](F)C3)sc2c1
Show InChI InChI=1S/C19H16F2N2OS/c1-10-3-2-4-14(21)17(10)11-5-6-15-16(9-11)25-19(22-15)23-18(24)12-7-13(20)8-12/h2-6,9,12-13H,7-8H2,1H3,(H,22,23,24)/t12-,13+
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n/an/a 215n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445990
PNG
(US10669246, Example 41)
Show SMILES Cc1cccc(F)c1-c1ccc2nc(NC(=O)C3C[C@H](F)C3)sc2c1
Show InChI InChI=1S/C19H16F2N2OS/c1-10-3-2-4-14(21)17(10)11-5-6-15-16(9-11)25-19(22-15)23-18(24)12-7-13(20)8-12/h2-6,9,12-13H,7-8H2,1H3,(H,22,23,24)/t12?,13-
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n/an/a 339n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445981
PNG
(US10669246, Example 34)
Show SMILES Cc1cccc(F)c1-c1ccc2nc(NC(=O)C3CCC3)sc2c1
Show InChI InChI=1S/C19H17FN2OS/c1-11-4-2-7-14(20)17(11)13-8-9-15-16(10-13)24-19(21-15)22-18(23)12-5-3-6-12/h2,4,7-10,12H,3,5-6H2,1H3,(H,21,22,23)
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n/an/a 364n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Homo sapiens (Human))
BDBM445956
PNG
(US10669246, Example 8)
Show SMILES Cc1c(F)cncc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C17H13F2N3OS/c1-8-11(6-20-7-13(8)19)9-2-3-14-15(4-9)24-17(21-14)22-16(23)10-5-12(10)18/h2-4,6-7,10,12H,5H2,1H3,(H,21,22,23)/t10-,12+/m1/s1
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n/an/a 391n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), Bovine serum albumin (BSA) and dimethylsulfoxide (DMSO) were purchased from...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445973
PNG
(US10669246, Example 26)
Show SMILES Cc1cccc(F)c1-c1cc2sc(NC(=O)[C@@H]3C[C@@H]3F)nc2cn1
Show InChI InChI=1S/C17H13F2N3OS/c1-8-3-2-4-10(18)15(8)12-6-14-13(7-20-12)21-17(24-14)22-16(23)9-5-11(9)19/h2-4,6-7,9,11H,5H2,1H3,(H,21,22,23)/t9-,11+/m1/s1
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n/an/a 423n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446016
PNG
(US10669246, Example 67)
Show SMILES Cc1cc(ncc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1)C(F)(F)F
Show InChI InChI=1S/C18H13F4N3OS/c1-8-4-15(18(20,21)22)23-7-11(8)9-2-3-13-14(5-9)27-17(24-13)25-16(26)10-6-12(10)19/h2-5,7,10,12H,6H2,1H3,(H,24,25,26)/t10-,12+/m1/s1
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n/an/a 455n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445967
PNG
(US10669246, Example 20)
Show SMILES Cc1cccc(F)c1-c1cnc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C17H13F2N3OS/c1-8-3-2-4-11(18)14(8)9-5-13-15(20-7-9)21-17(24-13)22-16(23)10-6-12(10)19/h2-5,7,10,12H,6H2,1H3,(H,20,21,22,23)/t10-,12+/m1/s1
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n/an/a 729n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446043
PNG
(US10669246, Example 94)
Show SMILES Cc1cn(nc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1)C1CCCCO1
Show InChI InChI=1S/C20H21FN4O2S/c1-11-10-25(17-4-2-3-7-27-17)24-18(11)12-5-6-15-16(8-12)28-20(22-15)23-19(26)13-9-14(13)21/h5-6,8,10,13-14,17H,2-4,7,9H2,1H3,(H,22,23,26)/t13-,14+,17?/m1/s1
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n/an/a 758n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445991
PNG
(US10669246, Example 42)
Show SMILES Cc1cccc(F)c1-c1ccc2nc(NC(=O)C3CC(F)(F)C3)sc2c1
Show InChI InChI=1S/C19H15F3N2OS/c1-10-3-2-4-13(20)16(10)11-5-6-14-15(7-11)26-18(23-14)24-17(25)12-8-19(21,22)9-12/h2-7,12H,8-9H2,1H3,(H,23,24,25)
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n/an/a 876n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM445969
PNG
(US10669246, Example 22)
Show SMILES Cc1c(O)cccc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C18H15FN2O2S/c1-9-11(3-2-4-15(9)22)10-5-6-14-16(7-10)24-18(20-14)21-17(23)12-8-13(12)19/h2-7,12-13,22H,8H2,1H3,(H,20,21,23)/t12-,13+/m1/s1
PDB

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n/an/a 1.02E+3n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), Manganese(II) chloride (MnCl2), Bovine serum albumin (BSA) and dimethylsulf...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Homo sapiens (Human))
BDBM445971
PNG
(US10669246, Example 24)
Show SMILES Cc1ccc2NCCc2c1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C20H18FN3OS/c1-10-2-4-15-12(6-7-22-15)18(10)11-3-5-16-17(8-11)26-20(23-16)24-19(25)13-9-14(13)21/h2-5,8,13-14,22H,6-7,9H2,1H3,(H,23,24,25)/t13-,14+/m1/s1
PDB

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n/an/a 1.16E+3n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), Bovine serum albumin (BSA) and dimethylsulfoxide (DMSO) were purchased from...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445982
PNG
(US10669246, Example 35)
Show SMILES Cc1c(F)cncc1-c1cnc2nc(NC(=O)C3CC3)sc2c1
Show InChI InChI=1S/C16H13FN4OS/c1-8-11(6-18-7-12(8)17)10-4-13-14(19-5-10)20-16(23-13)21-15(22)9-2-3-9/h4-7,9H,2-3H2,1H3,(H,19,20,21,22)
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n/an/a 1.16E+3n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Homo sapiens (Human))
BDBM445964
PNG
(US10669246, Example 17)
Show SMILES CC(=C)c1ccc(C)c(c1)-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C21H19FN2OS/c1-11(2)13-5-4-12(3)15(8-13)14-6-7-18-19(9-14)26-21(23-18)24-20(25)16-10-17(16)22/h4-9,16-17H,1,10H2,2-3H3,(H,23,24,25)/t16-,17+/m1/s1
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n/an/a 1.30E+3n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), Bovine serum albumin (BSA) and dimethylsulfoxide (DMSO) were purchased from...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM445962
PNG
(US10669246, Example 14)
Show SMILES Cc1ccc(O)cc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C18H15FN2O2S/c1-9-2-4-11(22)7-12(9)10-3-5-15-16(6-10)24-18(20-15)21-17(23)13-8-14(13)19/h2-7,13-14,22H,8H2,1H3,(H,20,21,23)/t13-,14+/m1/s1
PDB

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n/an/a 1.34E+3n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), Manganese(II) chloride (MnCl2), Bovine serum albumin (BSA) and dimethylsulf...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Homo sapiens (Human))
BDBM445953
PNG
(US10669246, Example 5)
Show SMILES Cc1ccncc1-c1ccc2nc(NC(=O)C3CC3)sc2c1
Show InChI InChI=1S/C17H15N3OS/c1-10-6-7-18-9-13(10)12-4-5-14-15(8-12)22-17(19-14)20-16(21)11-2-3-11/h4-9,11H,2-3H2,1H3,(H,19,20,21)
PDB

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n/an/a 1.61E+3n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), Bovine serum albumin (BSA) and dimethylsulfoxide (DMSO) were purchased from...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446025
PNG
(US10669246, Example 76)
Show SMILES CNC[C@@H]1CC1C(=O)Nc1nc2ccc(cc2s1)-c1cncc(F)c1C
Show InChI InChI=1S/C19H19FN4OS/c1-10-14(8-22-9-15(10)20)11-3-4-16-17(6-11)26-19(23-16)24-18(25)13-5-12(13)7-21-2/h3-4,6,8-9,12-13,21H,5,7H2,1-2H3,(H,23,24,25)/t12-,13?/m0/s1
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n/an/a 1.66E+3n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Homo sapiens (Human))
BDBM445952
PNG
(US10669246, Example 4)
Show SMILES Cc1ccncc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C17H14FN3OS/c1-9-4-5-19-8-12(9)10-2-3-14-15(6-10)23-17(20-14)21-16(22)11-7-13(11)18/h2-6,8,11,13H,7H2,1H3,(H,20,21,22)/t11-,13+/m1/s1
PDB

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n/an/a 1.97E+3n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), Bovine serum albumin (BSA) and dimethylsulfoxide (DMSO) were purchased from...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445978
PNG
(US10669246, Example 31)
Show SMILES Cc1ccc2[nH]ccc2c1-c1ccc2sc(NC(=O)[C@@H]3C[C@@H]3F)nc2c1
PDB
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n/an/a>2.00E+3n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445977
PNG
(US10669246, Example 30)
Show SMILES Cc1cccc(F)c1-c1ccc2sc(NC(=O)C3CC3)nc2c1
Show InChI InChI=1S/C18H15FN2OS/c1-10-3-2-4-13(19)16(10)12-7-8-15-14(9-12)20-18(23-15)21-17(22)11-5-6-11/h2-4,7-9,11H,5-6H2,1H3,(H,20,21,22)
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n/an/a>2.00E+3n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445972
PNG
(US10669246, Example 25)
Show SMILES Cc1ccc2n(COCC[Si](C)(C)C)ccc2c1-c1ccc2sc(NC(=O)[C@@H]3C[C@@H]3F)nc2c1
Show InChI InChI=1S/C26H30FN3O2SSi/c1-16-5-7-22-18(9-10-30(22)15-32-11-12-34(2,3)4)24(16)17-6-8-23-21(13-17)28-26(33-23)29-25(31)19-14-20(19)27/h5-10,13,19-20H,11-12,14-15H2,1-4H3,(H,28,29,31)/t19-,20+/m1/s1
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n/an/a>2.00E+3n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445965
PNG
(US10669246, Example 18)
Show SMILES Cc1ccncc1-c1cnc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C16H13FN4OS/c1-8-2-3-18-7-11(8)9-4-13-14(19-6-9)20-16(23-13)21-15(22)10-5-12(10)17/h2-4,6-7,10,12H,5H2,1H3,(H,19,20,21,22)/t10-,12+/m1/s1
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n/an/a>2.00E+3n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445974
PNG
(US10669246, Example 27)
Show SMILES Cc1ccncc1-c1ccc2nc(N)sc2c1
Show InChI InChI=1S/C13H11N3S/c1-8-4-5-15-7-10(8)9-2-3-11-12(6-9)17-13(14)16-11/h2-7H,1H3,(H2,14,16)
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n/an/a>2.00E+3n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445980
PNG
(US10669246, Example 33)
Show SMILES Cc1cccc(F)c1-c1ccc2sc(NC(=O)C3C[C@H]3CO)nc2c1
Show InChI InChI=1S/C19H17FN2O2S/c1-10-3-2-4-14(20)17(10)11-5-6-16-15(8-11)21-19(25-16)22-18(24)13-7-12(13)9-23/h2-6,8,12-13,23H,7,9H2,1H3,(H,21,22,24)/t12-,13?/m0/s1
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n/an/a>2.00E+3n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445976
PNG
(US10669246, Example 29)
Show SMILES Cc1cc(CO)ncc1-c1ccc2sc(NC(=O)[C@@H]3C[C@@H]3F)nc2c1
Show InChI InChI=1S/C18H16FN3O2S/c1-9-4-11(8-23)20-7-13(9)10-2-3-16-15(5-10)21-18(25-16)22-17(24)12-6-14(12)19/h2-5,7,12,14,23H,6,8H2,1H3,(H,21,22,24)/t12-,14+/m1/s1
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n/an/a>2.00E+3n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445968
PNG
(US10669246, Example 21)
Show SMILES CC(=O)c1cc(C)c(cn1)-c1ccc2sc(NC(=O)[C@@H]3C[C@@H]3F)nc2c1
Show InChI InChI=1S/C19H16FN3O2S/c1-9-5-15(10(2)24)21-8-13(9)11-3-4-17-16(6-11)22-19(26-17)23-18(25)12-7-14(12)20/h3-6,8,12,14H,7H2,1-2H3,(H,22,23,25)/t12-,14+/m1/s1
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n/an/a>2.00E+3n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445975
PNG
(US10669246, Example 28)
Show SMILES CC(O)c1cc(C)c(cn1)-c1ccc2sc(NC(=O)[C@@H]3C[C@@H]3F)nc2c1
Show InChI InChI=1S/C19H18FN3O2S/c1-9-5-15(10(2)24)21-8-13(9)11-3-4-17-16(6-11)22-19(26-17)23-18(25)12-7-14(12)20/h3-6,8,10,12,14,24H,7H2,1-2H3,(H,22,23,25)/t10?,12-,14+/m1/s1
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n/an/a>2.00E+3n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446020
PNG
(US10669246, Example 71)
Show SMILES CNC[C@@H]1CC1C(=O)Nc1nc2ccc(cc2s1)-c1c(C)cccc1F
Show InChI InChI=1S/C20H20FN3OS/c1-11-4-3-5-15(21)18(11)12-6-7-16-17(9-12)26-20(23-16)24-19(25)14-8-13(14)10-22-2/h3-7,9,13-14,22H,8,10H2,1-2H3,(H,23,24,25)/t13-,14?/m0/s1
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n/an/a>2.00E+3n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Homo sapiens (Human))
BDBM445949
PNG
(US10669246, Example 1)
Show SMILES Cc1cccc(F)c1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C18H14F2N2OS/c1-9-3-2-4-12(19)16(9)10-5-6-14-15(7-10)24-18(21-14)22-17(23)11-8-13(11)20/h2-7,11,13H,8H2,1H3,(H,21,22,23)/t11-,13+/m1/s1
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n/an/a>3.10E+3n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), Bovine serum albumin (BSA) and dimethylsulfoxide (DMSO) were purchased from...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM445956
PNG
(US10669246, Example 8)
Show SMILES Cc1c(F)cncc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C17H13F2N3OS/c1-8-11(6-20-7-13(8)19)9-2-3-14-15(4-9)24-17(21-14)22-16(23)10-5-12(10)18/h2-4,6-7,10,12H,5H2,1H3,(H,21,22,23)/t10-,12+/m1/s1
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n/an/a 3.13E+3n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), Manganese(II) chloride (MnCl2), Bovine serum albumin (BSA) and dimethylsulf...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM445951
PNG
(US10669246, Example 3)
Show SMILES Cc1cccc(C)c1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C19H17FN2OS/c1-10-4-3-5-11(2)17(10)12-6-7-15-16(8-12)24-19(21-15)22-18(23)13-9-14(13)20/h3-8,13-14H,9H2,1-2H3,(H,21,22,23)/t13-,14+/m1/s1
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n/an/a 3.85E+3n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), Manganese(II) chloride (MnCl2), Bovine serum albumin (BSA) and dimethylsulf...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM445950
PNG
(US10669246, Example 2)
Show SMILES Cc1cccc(Cl)c1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C18H14ClFN2OS/c1-9-3-2-4-12(19)16(9)10-5-6-14-15(7-10)24-18(21-14)22-17(23)11-8-13(11)20/h2-7,11,13H,8H2,1H3,(H,21,22,23)/t11-,13+/m1/s1
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n/an/a 4.02E+3n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), Manganese(II) chloride (MnCl2), Bovine serum albumin (BSA) and dimethylsulf...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445994
PNG
(US10669246, Example 45)
Show SMILES CN(C(=O)OC(C)(C)C)c1ccc(C)c(-c2ccc3nc(NC(=O)[C@@H]4C[C@@H]4F)sc3c2)c1F
Show InChI InChI=1S/C24H25F2N3O3S/c1-12-6-9-17(29(5)23(31)32-24(2,3)4)20(26)19(12)13-7-8-16-18(10-13)33-22(27-16)28-21(30)14-11-15(14)25/h6-10,14-15H,11H2,1-5H3,(H,27,28,30)/t14-,15+/m1/s1
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n/an/a 5.31E+3n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Homo sapiens (Human))
BDBM445983
PNG
(US10669246, Example 36)
Show SMILES Cc1ccncc1-c1ccc2nc(NC(=O)C3CC3(F)F)sc2c1
Show InChI InChI=1S/C17H13F2N3OS/c1-9-4-5-20-8-11(9)10-2-3-13-14(6-10)24-16(21-13)22-15(23)12-7-17(12,18)19/h2-6,8,12H,7H2,1H3,(H,21,22,23)
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n/an/a 5.76E+3n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), Bovine serum albumin (BSA) and dimethylsulfoxide (DMSO) were purchased from...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446001
PNG
(US10669246, Example 52)
Show SMILES Cc1ccncc1-c1ccc2nc(NC(=O)c3ccccc3)sc2c1
Show InChI InChI=1S/C20H15N3OS/c1-13-9-10-21-12-16(13)15-7-8-17-18(11-15)25-20(22-17)23-19(24)14-5-3-2-4-6-14/h2-12H,1H3,(H,22,23,24)
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n/an/a 5.77E+3n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Homo sapiens (Human))
BDBM445951
PNG
(US10669246, Example 3)
Show SMILES Cc1cccc(C)c1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C19H17FN2OS/c1-10-4-3-5-11(2)17(10)12-6-7-15-16(8-12)24-19(21-15)22-18(23)13-9-14(13)20/h3-8,13-14H,9H2,1-2H3,(H,21,22,23)/t13-,14+/m1/s1
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n/an/a 8.38E+3n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), Bovine serum albumin (BSA) and dimethylsulfoxide (DMSO) were purchased from...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445961
PNG
(US10669246, Example 13)
Show SMILES Cc1ccncc1-c1cnc2nc(NC(=O)C3CC3)sc2c1
Show InChI InChI=1S/C16H14N4OS/c1-9-4-5-17-8-12(9)11-6-13-14(18-7-11)19-16(22-13)20-15(21)10-2-3-10/h4-8,10H,2-3H2,1H3,(H,18,19,20,21)
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n/an/a 9.50E+3n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446061
PNG
(US10669246, Example 112)
Show SMILES CN(C(=O)[C@@H]1C[C@@H]1F)c1nc2ccc(cc2s1)-c1cnccc1C
Show InChI InChI=1S/C18H16FN3OS/c1-10-5-6-20-9-13(10)11-3-4-15-16(7-11)24-18(21-15)22(2)17(23)12-8-14(12)19/h3-7,9,12,14H,8H2,1-2H3/t12-,14+/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM445964
PNG
(US10669246, Example 17)
Show SMILES CC(=C)c1ccc(C)c(c1)-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C21H19FN2OS/c1-11(2)13-5-4-12(3)15(8-13)14-6-7-18-19(9-14)26-21(23-18)24-20(25)16-10-17(16)22/h4-9,16-17H,1,10H2,2-3H3,(H,23,24,25)/t16-,17+/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), Manganese(II) chloride (MnCl2), Bovine serum albumin (BSA) and dimethylsulf...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM445949
PNG
(US10669246, Example 1)
Show SMILES Cc1cccc(F)c1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C18H14F2N2OS/c1-9-3-2-4-12(19)16(9)10-5-6-14-15(7-10)24-18(21-14)22-17(23)11-8-13(11)20/h2-7,11,13H,8H2,1H3,(H,21,22,23)/t11-,13+/m1/s1
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), Manganese(II) chloride (MnCl2), Bovine serum albumin (BSA) and dimethylsulf...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Homo sapiens (Human))
BDBM445950
PNG
(US10669246, Example 2)
Show SMILES Cc1cccc(Cl)c1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C18H14ClFN2OS/c1-9-3-2-4-12(19)16(9)10-5-6-14-15(7-10)24-18(21-14)22-17(23)11-8-13(11)20/h2-7,11,13H,8H2,1H3,(H,21,22,23)/t11-,13+/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), Bovine serum albumin (BSA) and dimethylsulfoxide (DMSO) were purchased from...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM445952
PNG
(US10669246, Example 4)
Show SMILES Cc1ccncc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C17H14FN3OS/c1-9-4-5-19-8-12(9)10-2-3-14-15(6-10)23-17(20-14)21-16(22)11-7-13(11)18/h2-6,8,11,13H,7H2,1H3,(H,20,21,22)/t11-,13+/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), Manganese(II) chloride (MnCl2), Bovine serum albumin (BSA) and dimethylsulf...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM445971
PNG
(US10669246, Example 24)
Show SMILES Cc1ccc2NCCc2c1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C20H18FN3OS/c1-10-2-4-15-12(6-7-22-15)18(10)11-3-5-16-17(8-11)26-20(23-16)24-19(25)13-9-14(13)21/h2-5,8,13-14,22H,6-7,9H2,1H3,(H,23,24,25)/t13-,14+/m1/s1
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), Manganese(II) chloride (MnCl2), Bovine serum albumin (BSA) and dimethylsulf...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445955
PNG
(US10669246, Example 7)
Show SMILES Cc1ccncc1-c1ccc2sc(NC(=O)C3CC3)nc2c1
Show InChI InChI=1S/C17H15N3OS/c1-10-6-7-18-9-13(10)12-4-5-15-14(8-12)19-17(22-15)20-16(21)11-2-3-11/h4-9,11H,2-3H2,1H3,(H,19,20,21)
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n/an/a>1.00E+4n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Homo sapiens (Human))
BDBM445960
PNG
(US10669246, Example 12)
Show SMILES Cc1ccnc(C)c1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C18H16FN3OS/c1-9-5-6-20-10(2)16(9)11-3-4-14-15(7-11)24-18(21-14)22-17(23)12-8-13(12)19/h3-7,12-13H,8H2,1-2H3,(H,21,22,23)/t12-,13+/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), Bovine serum albumin (BSA) and dimethylsulfoxide (DMSO) were purchased from...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM445954
PNG
(US10669246, Example 6)
Show SMILES Cc1ccncc1-c1ccc2sc(NC(=O)[C@@H]3C[C@@H]3F)nc2c1
Show InChI InChI=1S/C17H14FN3OS/c1-9-4-5-19-8-12(9)10-2-3-15-14(6-10)20-17(23-15)21-16(22)11-7-13(11)18/h2-6,8,11,13H,7H2,1H3,(H,20,21,22)/t11-,13+/m1/s1
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1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM445983
PNG
(US10669246, Example 36)
Show SMILES Cc1ccncc1-c1ccc2nc(NC(=O)C3CC3(F)F)sc2c1
Show InChI InChI=1S/C17H13F2N3OS/c1-9-4-5-20-8-11(9)10-2-3-13-14(6-10)24-16(21-13)22-15(23)12-7-17(12,18)19/h2-6,8,12H,7H2,1H3,(H,21,22,23)
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n/an/a>1.00E+4n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), Manganese(II) chloride (MnCl2), Bovine serum albumin (BSA) and dimethylsulf...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446002
PNG
(US10669246, Example 53)
Show SMILES CNc1nc2ccc(cc2s1)-c1cnccc1C
Show InChI InChI=1S/C14H13N3S/c1-9-5-6-16-8-11(9)10-3-4-12-13(7-10)18-14(15-2)17-12/h3-8H,1-2H3,(H,15,17)
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n/an/a>1.00E+4n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Cereblon/BCR/ABL


(Homo sapiens (Human))
BDBM446003
PNG
(US10669246, Example 54)
Show SMILES Cc1ccncc1-c1ccc2n(C)c(=N)sc2c1
Show InChI InChI=1S/C14H13N3S/c1-9-5-6-16-8-11(9)10-3-4-12-13(7-10)18-14(15)17(12)2/h3-8,15H,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM445960
PNG
(US10669246, Example 12)
Show SMILES Cc1ccnc(C)c1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1
Show InChI InChI=1S/C18H16FN3OS/c1-9-5-6-20-10(2)16(9)11-3-4-14-15(7-11)24-18(21-14)22-17(23)12-8-13(12)19/h3-7,12-13H,8H2,1-2H3,(H,21,22,23)/t12-,13+/m1/s1
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



1ST Biotherapeutics, Inc.

US Patent


Assay Description
ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), Manganese(II) chloride (MnCl2), Bovine serum albumin (BSA) and dimethylsulf...


US Patent US10669246 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%