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Patent code US10669265

Compile Data Set for Download or QSAR
Found 142 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365349
PNG
(US10633373, Example 54 | US10669265, Example 54 | ...)
Show SMILES COC(=O)CCCC[S@](C)(=O)=NC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3cc(C)ccc3F)ccc2s1
Show InChI InChI=1S/C29H30FN5O5S2/c1-17-7-9-22(30)23(12-17)34-29(38)33-20-8-10-24-18(13-20)15-25(41-24)21-14-19(16-32-27(21)31)28(37)35-42(3,39)11-5-4-6-26(36)40-2/h7-10,12-16H,4-6,11H2,1-3H3,(H2,31,32)(H2,33,34,38)/t42-/m0/s1
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n/an/a 3n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM363234
PNG
(6-amino-5-[5-({[(3-chloro-4- fluorophenyl)amino]ca...)
Show SMILES CS(C)(=O)=NC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccc(F)c(Cl)c3)ccc2s1
Show InChI InChI=1S/C23H19ClFN5O3S2/c1-35(2,33)30-22(31)13-8-16(21(26)27-11-13)20-9-12-7-14(4-6-19(12)34-20)28-23(32)29-15-3-5-18(25)17(24)10-15/h3-11H,1-2H3,(H2,26,27)(H2,28,29,32)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM363243
PNG
(6-amino-N-[dimethyl(oxido)- lambda4-sulfanylidene]...)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc3sc(cc3c2)-c2cc(cnc2N)C(=O)N=S(C)(C)=O)c1
Show InChI InChI=1S/C24H22FN5O3S2/c1-13-4-6-18(25)19(8-13)29-24(32)28-16-5-7-20-14(9-16)11-21(34-20)17-10-15(12-27-22(17)26)23(31)30-35(2,3)33/h4-12H,1-3H3,(H2,26,27)(H2,28,29,32)
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ALLERGAN, INC.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365350
PNG
(US10633373, Example 55 | US10669265, Example 55 | ...)
Show SMILES COC(=O)CCCC[S@](C)(=O)=NC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccc(F)c(Cl)c3)ccc2s1
Show InChI InChI=1S/C28H27ClFN5O5S2/c1-40-25(36)5-3-4-10-42(2,39)35-27(37)17-12-20(26(31)32-15-17)24-13-16-11-18(7-9-23(16)41-24)33-28(38)34-19-6-8-22(30)21(29)14-19/h6-9,11-15H,3-5,10H2,1-2H3,(H2,31,32)(H2,33,34,38)/t42-/m0/s1
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n/an/a 4n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM364984
PNG
(6-amino-N-[dimethyl(oxido)- lambda4-sulfanylidene]...)
Show SMILES CS(C)(=O)=NC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3cc(ccc3F)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C24H19F4N5O3S2/c1-38(2,36)33-22(34)13-8-16(21(29)30-11-13)20-9-12-7-15(4-6-19(12)37-20)31-23(35)32-18-10-14(24(26,27)28)3-5-17(18)25/h3-11H,1-2H3,(H2,29,30)(H2,31,32,35)
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ALLERGAN, INC.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365348
PNG
(US10633373, Example 53 | US10669265, Example 53 | ...)
Show SMILES COC(=O)CCCC[S@](C)(=O)=NC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3cccc(C)c3)ccc2s1
Show InChI InChI=1S/C29H31N5O5S2/c1-18-7-6-8-21(13-18)32-29(37)33-22-10-11-24-19(14-22)16-25(40-24)23-15-20(17-31-27(23)30)28(36)34-41(3,38)12-5-4-9-26(35)39-2/h6-8,10-11,13-17H,4-5,9,12H2,1-3H3,(H2,30,31)(H2,32,33,37)/t41-/m0/s1
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM364980
PNG
(6-amino-5-{5-[({[4-chloro-3- (trifluoromethyl)phen...)
Show SMILES CS(C)(=O)=NC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C24H19ClF3N5O3S2/c1-38(2,36)33-22(34)13-8-16(21(29)30-11-13)20-9-12-7-14(4-6-19(12)37-20)31-23(35)32-15-3-5-18(25)17(10-15)24(26,27)28/h3-11H,1-2H3,(H2,29,30)(H2,31,32,35)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM364984
PNG
(6-amino-N-[dimethyl(oxido)- lambda4-sulfanylidene]...)
Show SMILES CS(C)(=O)=NC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3cc(ccc3F)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C24H19F4N5O3S2/c1-38(2,36)33-22(34)13-8-16(21(29)30-11-13)20-9-12-7-15(4-6-19(12)37-20)31-23(35)32-18-10-14(24(26,27)28)3-5-17(18)25/h3-11H,1-2H3,(H2,29,30)(H2,31,32,35)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365355
PNG
(6-amino-N-[dimethyl(oxido)- lambda4-sulfanylidene]...)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cc(cnc2N)C(=O)N=S(C)(C)=O)c1
Show InChI InChI=1S/C22H22FN5O3S/c1-13-4-9-18(23)19(10-13)27-22(30)26-16-7-5-14(6-8-16)17-11-15(12-25-20(17)24)21(29)28-32(2,3)31/h4-12H,1-3H3,(H2,24,25)(H2,26,27,30)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365314
PNG
(6-amino-N-[dimethyl(oxido)- lambda4-sulfanylidene]...)
Show SMILES Cc1ccoc1C(=O)Nc1ccc2sc(cc2c1)-c1cc(cnc1N)C(=O)N=S(C)(C)=O
Show InChI InChI=1S/C22H20N4O4S2/c1-12-6-7-30-19(12)22(28)25-15-4-5-17-13(8-15)10-18(31-17)16-9-14(11-24-20(16)23)21(27)26-32(2,3)29/h4-11H,1-3H3,(H2,23,24)(H,25,28)
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n/an/a 6n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365352
PNG
(N-[dimethyl(oxido)-lambda4- sulfanylidene]-5-{5-[(...)
Show SMILES CS(C)(=O)=NC(=O)c1cncc(c1)-c1cc2cc(NC(=O)Nc3cc(ccc3F)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C24H18F4N4O3S2/c1-37(2,35)32-22(33)15-7-14(11-29-12-15)21-9-13-8-17(4-6-20(13)36-21)30-23(34)31-19-10-16(24(26,27)28)3-5-18(19)25/h3-12H,1-2H3,(H2,30,31,34)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM364986
PNG
(US10633373, Example 7 | US10669265, Example 7 | US...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3cccc(c3)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C23H17F3N4O3S/c1-33-21(31)13-8-17(20(27)28-11-13)19-9-12-7-16(5-6-18(12)34-19)30-22(32)29-15-4-2-3-14(10-15)23(24,25)26/h2-11H,1H3,(H2,27,28)(H2,29,30,32)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365369
PNG
(US10633373, Example 74 | US10669265, Example 74 | ...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1ccc(NC(=O)Nc2cc(ccc2F)C(F)(F)F)cc1
Show InChI InChI=1S/C21H16F4N4O3/c1-32-19(30)12-8-15(18(26)27-10-12)11-2-5-14(6-3-11)28-20(31)29-17-9-13(21(23,24)25)4-7-16(17)22/h2-10H,1H3,(H2,26,27)(H2,28,29,31)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365370
PNG
(US10633373, Example 75 | US10669265, Example 75 | ...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1ccc(NC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)cc1
Show InChI InChI=1S/C21H16ClF3N4O3/c1-32-19(30)12-8-15(18(26)27-10-12)11-2-4-13(5-3-11)28-20(31)29-14-6-7-17(22)16(9-14)21(23,24)25/h2-10H,1H3,(H2,26,27)(H2,28,29,31)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365351
PNG
(6-amino-N-[bis(3- hydroxypropyl)(oxido)-lambda4- s...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc3sc(cc3c2)-c2cc(cnc2N)C(=O)N=S(=O)(CCCO)CCCO)c1
Show InChI InChI=1S/C28H31N5O5S2/c1-18-5-2-6-21(13-18)31-28(37)32-22-7-8-24-19(14-22)16-25(39-24)23-15-20(17-30-26(23)29)27(36)33-40(38,11-3-9-34)12-4-10-35/h2,5-8,13-17,34-35H,3-4,9-12H2,1H3,(H2,29,30)(H2,31,32,37)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM363243
PNG
(6-amino-N-[dimethyl(oxido)- lambda4-sulfanylidene]...)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc3sc(cc3c2)-c2cc(cnc2N)C(=O)N=S(C)(C)=O)c1
Show InChI InChI=1S/C24H22FN5O3S2/c1-13-4-6-18(25)19(8-13)29-24(32)28-16-5-7-20-14(9-16)11-21(34-20)17-10-15(12-27-22(17)26)23(31)30-35(2,3)33/h4-12H,1-3H3,(H2,26,27)(H2,28,29,32)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM363197
PNG
(6-amino-N-[dimethyl(oxido)- lambda4-sulfanylidene]...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc3sc(cc3c2)-c2cc(cnc2N)C(=O)N=S(C)(C)=O)c1
Show InChI InChI=1S/C24H23N5O3S2/c1-14-5-4-6-17(9-14)27-24(31)28-18-7-8-20-15(10-18)12-21(33-20)19-11-16(13-26-22(19)25)23(30)29-34(2,3)32/h4-13H,1-3H3,(H2,25,26)(H2,27,28,31)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM365351
PNG
(6-amino-N-[bis(3- hydroxypropyl)(oxido)-lambda4- s...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc3sc(cc3c2)-c2cc(cnc2N)C(=O)N=S(=O)(CCCO)CCCO)c1
Show InChI InChI=1S/C28H31N5O5S2/c1-18-5-2-6-21(13-18)31-28(37)32-22-7-8-24-19(14-22)16-25(39-24)23-15-20(17-30-26(23)29)27(36)33-40(38,11-3-9-34)12-4-10-35/h2,5-8,13-17,34-35H,3-4,9-12H2,1H3,(H2,29,30)(H2,31,32,37)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM364999
PNG
(US10633373, Example 16 | US10669265, Example 16 | ...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccc(F)cc3F)ccc2s1
Show InChI InChI=1S/C22H16F2N4O3S/c1-31-21(29)12-7-15(20(25)26-10-12)19-8-11-6-14(3-5-18(11)32-19)27-22(30)28-17-4-2-13(23)9-16(17)24/h2-10H,1H3,(H2,25,26)(H2,27,28,30)
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n/an/a 9n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365368
PNG
(US10633373, Example 73 | US10669265, Example 73 | ...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1ccc(NC(=O)Nc2cc(C)ccc2F)cc1
Show InChI InChI=1S/C21H19FN4O3/c1-12-3-8-17(22)18(9-12)26-21(28)25-15-6-4-13(5-7-15)16-10-14(20(27)29-2)11-24-19(16)23/h3-11H,1-2H3,(H2,23,24)(H2,25,26,28)
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n/an/a 9n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM364990
PNG
(US10633373, Example 8 | US10669265, Example 8 | US...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3cc(ccc3F)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C23H16F4N4O3S/c1-34-21(32)12-7-15(20(28)29-10-12)19-8-11-6-14(3-5-18(11)35-19)30-22(33)31-17-9-13(23(25,26)27)2-4-16(17)24/h2-10H,1H3,(H2,28,29)(H2,30,31,33)
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n/an/a 10n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM365217
PNG
(1-{2-[2-amino-5-(4,4,5,5- tetramethyl-1,3,2- dioxa...)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc3sc(cc3c2)-c2cc(cnc2N)B2OC(C)(C)C(C)(C)O2)c1
Show InChI InChI=1S/C27H28BFN4O3S/c1-15-6-8-20(29)21(10-15)33-25(34)32-18-7-9-22-16(11-18)12-23(37-22)19-13-17(14-31-24(19)30)28-35-26(2,3)27(4,5)36-28/h6-14H,1-5H3,(H2,30,31)(H2,32,33,34)
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n/an/a 10n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM364997
PNG
(US10633373, Example 14 | US10669265, Example 14 | ...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccccc3F)ccc2s1
Show InChI InChI=1S/C22H17FN4O3S/c1-30-21(28)13-9-15(20(24)25-11-13)19-10-12-8-14(6-7-18(12)31-19)26-22(29)27-17-5-3-2-4-16(17)23/h2-11H,1H3,(H2,24,25)(H2,26,27,29)
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n/an/a 10n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365013
PNG
(1-{2-[2-amino-5-(4,4,5,5- tetramethyl-1,3,2- dioxa...)
Show SMILES CC1(C)OB(OC1(C)C)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3cc(ccc3F)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C27H25BF4N4O3S/c1-25(2)26(3,4)39-28(38-25)16-12-18(23(33)34-13-16)22-10-14-9-17(6-8-21(14)40-22)35-24(37)36-20-11-15(27(30,31)32)5-7-19(20)29/h5-13H,1-4H3,(H2,33,34)(H2,35,36,37)
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n/an/a 10n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM364980
PNG
(6-amino-5-{5-[({[4-chloro-3- (trifluoromethyl)phen...)
Show SMILES CS(C)(=O)=NC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C24H19ClF3N5O3S2/c1-38(2,36)33-22(34)13-8-16(21(29)30-11-13)20-9-12-7-14(4-6-19(12)37-20)31-23(35)32-15-3-5-18(25)17(10-15)24(26,27)28/h3-11H,1-2H3,(H2,29,30)(H2,31,32,35)
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n/an/a 11n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM364986
PNG
(US10633373, Example 7 | US10669265, Example 7 | US...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3cccc(c3)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C23H17F3N4O3S/c1-33-21(31)13-8-17(20(27)28-11-13)19-9-12-7-16(5-6-18(12)34-19)30-22(32)29-15-4-2-3-14(10-15)23(24,25)26/h2-11H,1H3,(H2,27,28)(H2,29,30,32)
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n/an/a 11n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM364990
PNG
(US10633373, Example 8 | US10669265, Example 8 | US...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3cc(ccc3F)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C23H16F4N4O3S/c1-34-21(32)12-7-15(20(28)29-10-12)19-8-11-6-14(3-5-18(11)35-19)30-22(33)31-17-9-13(23(25,26)27)2-4-16(17)24/h2-10H,1H3,(H2,28,29)(H2,30,31,33)
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n/an/a 12n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM364996
PNG
(US10633373, Example 13 | US10669265, Example 13 | ...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccc(C)cc3)ccc2s1
Show InChI InChI=1S/C23H20N4O3S/c1-13-3-5-16(6-4-13)26-23(29)27-17-7-8-19-14(9-17)11-20(31-19)18-10-15(22(28)30-2)12-25-21(18)24/h3-12H,1-2H3,(H2,24,25)(H2,26,27,29)
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n/an/a 12n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365364
PNG
(6-amino-N-[bis(3- hydroxypropyl)(oxido)-lambda6- s...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cc(cnc2N)C(=O)N=S(=O)(CCCO)CCCO)c1
Show InChI InChI=1S/C26H31N5O5S/c1-18-5-2-6-22(15-18)30-26(35)29-21-9-7-19(8-10-21)23-16-20(17-28-24(23)27)25(34)31-37(36,13-3-11-32)14-4-12-33/h2,5-10,15-17,32-33H,3-4,11-14H2,1H3,(H2,27,28)(H2,29,30,35)
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n/an/a 13n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365015
PNG
(1-{2-[2-amino-5-(4,4,5,5- tetramethyl-1,3,2- dioxa...)
Show SMILES CC1(C)OB(OC1(C)C)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3cccc(c3)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C27H26BF3N4O3S/c1-25(2)26(3,4)38-28(37-25)17-13-20(23(32)33-14-17)22-11-15-10-19(8-9-21(15)39-22)35-24(36)34-18-7-5-6-16(12-18)27(29,30)31/h5-14H,1-4H3,(H2,32,33)(H2,34,35,36)
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n/an/a 13n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM365367
PNG
(US10633373, Example 72 | US10669265, Example 72 | ...)
Show SMILES COC(=O)CCCCS(=O)(CCCCC(=O)OC)=NC(=O)c1cnc(N)c(c1)-c1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1
Show InChI InChI=1S/C32H36F3N5O7S/c1-46-27(41)10-3-5-16-48(45,17-6-4-11-28(42)47-2)40-30(43)22-18-26(29(36)37-20-22)21-12-14-24(15-13-21)38-31(44)39-25-9-7-8-23(19-25)32(33,34)35/h7-9,12-15,18-20H,3-6,10-11,16-17H2,1-2H3,(H2,36,37)(H2,38,39,44)
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n/an/a 13n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365353
PNG
(5-{5-[({[4-chloro-3- (trifluoromethyl)phenyl]amino...)
Show SMILES CS(C)(=O)=NC(=O)c1cncc(c1)-c1cc2cc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C24H18ClF3N4O3S2/c1-37(2,35)32-22(33)15-7-14(11-29-12-15)21-9-13-8-16(4-6-20(13)36-21)30-23(34)31-17-3-5-19(25)18(10-17)24(26,27)28/h3-12H,1-2H3,(H2,30,31,34)
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n/an/a 14n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365365
PNG
(US10633373, Example 70 | US10669265, Example 70 | ...)
Show SMILES COC(=O)CCCCS(=O)(CCCCC(=O)OC)=NC(=O)c1cnc(N)c(c1)-c1ccc(NC(=O)Nc2cccc(C)c2)cc1
Show InChI InChI=1S/C32H39N5O7S/c1-22-9-8-10-26(19-22)36-32(41)35-25-15-13-23(14-16-25)27-20-24(21-34-30(27)33)31(40)37-45(42,17-6-4-11-28(38)43-2)18-7-5-12-29(39)44-3/h8-10,13-16,19-21H,4-7,11-12,17-18H2,1-3H3,(H2,33,34)(H2,35,36,41)
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n/an/a 14n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM364992
PNG
(US10633373, Example 10 | US10669265, Example 10 | ...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3cc(C)ccc3F)ccc2s1
Show InChI InChI=1S/C23H19FN4O3S/c1-12-3-5-17(24)18(7-12)28-23(30)27-15-4-6-19-13(8-15)10-20(32-19)16-9-14(22(29)31-2)11-26-21(16)25/h3-11H,1-2H3,(H2,25,26)(H2,27,28,30)
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n/an/a 15n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM364991
PNG
(US10633373, Example 9 | US10669265, Example 9 | US...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C23H16ClF3N4O3S/c1-34-21(32)12-7-15(20(28)29-10-12)19-8-11-6-13(3-5-18(11)35-19)30-22(33)31-14-2-4-17(24)16(9-14)23(25,26)27/h2-10H,1H3,(H2,28,29)(H2,30,31,33)
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n/an/a 15n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM365348
PNG
(US10633373, Example 53 | US10669265, Example 53 | ...)
Show SMILES COC(=O)CCCC[S@](C)(=O)=NC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3cccc(C)c3)ccc2s1
Show InChI InChI=1S/C29H31N5O5S2/c1-18-7-6-8-21(13-18)32-29(37)33-22-10-11-24-19(14-22)16-25(40-24)23-15-20(17-31-27(23)30)28(36)34-41(3,38)12-5-4-9-26(35)39-2/h6-8,10-11,13-17H,4-5,9,12H2,1-3H3,(H2,30,31)(H2,32,33,37)/t41-/m0/s1
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n/an/a 16n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365216
PNG
(1-{2-[2-amino-5-(4,4,5,5- tetramethyl-1,3,2- dioxa...)
Show SMILES CC1(C)OB(OC1(C)C)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C27H25BClF3N4O3S/c1-25(2)26(3,4)39-28(38-25)15-11-18(23(33)34-13-15)22-10-14-9-16(6-8-21(14)40-22)35-24(37)36-17-5-7-20(29)19(12-17)27(30,31)32/h5-13H,1-4H3,(H2,33,34)(H2,35,36,37)
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n/an/a 16n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM363234
PNG
(6-amino-5-[5-({[(3-chloro-4- fluorophenyl)amino]ca...)
Show SMILES CS(C)(=O)=NC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccc(F)c(Cl)c3)ccc2s1
Show InChI InChI=1S/C23H19ClFN5O3S2/c1-35(2,33)30-22(31)13-8-16(21(26)27-11-13)20-9-12-7-14(4-6-19(12)34-20)28-23(32)29-15-3-5-18(25)17(24)10-15/h3-11H,1-2H3,(H2,26,27)(H2,28,29,32)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365314
PNG
(6-amino-N-[dimethyl(oxido)- lambda4-sulfanylidene]...)
Show SMILES Cc1ccoc1C(=O)Nc1ccc2sc(cc2c1)-c1cc(cnc1N)C(=O)N=S(C)(C)=O
Show InChI InChI=1S/C22H20N4O4S2/c1-12-6-7-30-19(12)22(28)25-15-4-5-17-13(8-15)10-18(31-17)16-9-14(11-24-20(16)23)21(27)26-32(2,3)29/h4-11H,1-3H3,(H2,23,24)(H,25,28)
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n/an/a 17n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM364992
PNG
(US10633373, Example 10 | US10669265, Example 10 | ...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3cc(C)ccc3F)ccc2s1
Show InChI InChI=1S/C23H19FN4O3S/c1-12-3-5-17(24)18(7-12)28-23(30)27-15-4-6-19-13(8-15)10-20(32-19)16-9-14(22(29)31-2)11-26-21(16)25/h3-11H,1-2H3,(H2,25,26)(H2,27,28,30)
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n/an/a 17n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM363243
PNG
(6-amino-N-[dimethyl(oxido)- lambda4-sulfanylidene]...)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc3sc(cc3c2)-c2cc(cnc2N)C(=O)N=S(C)(C)=O)c1
Show InChI InChI=1S/C24H22FN5O3S2/c1-13-4-6-18(25)19(8-13)29-24(32)28-16-5-7-20-14(9-16)11-21(34-20)17-10-15(12-27-22(17)26)23(31)30-35(2,3)33/h4-12H,1-3H3,(H2,26,27)(H2,28,29,32)
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n/an/a 17n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM365013
PNG
(1-{2-[2-amino-5-(4,4,5,5- tetramethyl-1,3,2- dioxa...)
Show SMILES CC1(C)OB(OC1(C)C)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3cc(ccc3F)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C27H25BF4N4O3S/c1-25(2)26(3,4)39-28(38-25)16-12-18(23(33)34-13-16)22-10-14-9-17(6-8-21(14)40-22)35-24(37)36-20-11-15(27(30,31)32)5-7-19(20)29/h5-13H,1-4H3,(H2,33,34)(H2,35,36,37)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM364994
PNG
(US10633373, Example 11 | US10669265, Example 11 | ...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3cccc(C)c3)ccc2s1
Show InChI InChI=1S/C23H20N4O3S/c1-13-4-3-5-16(8-13)26-23(29)27-17-6-7-19-14(9-17)11-20(31-19)18-10-15(22(28)30-2)12-25-21(18)24/h3-12H,1-2H3,(H2,24,25)(H2,26,27,29)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM365308
PNG
(1-{2-[2-amino-5-(4,4,5,5- tetramethyl-1,3,2- dioxa...)
Show SMILES CCc1cccc(NC(=O)Nc2ccc3sc(cc3c2)-c2cc(cnc2N)B2OC(C)(C)C(C)(C)O2)c1
Show InChI InChI=1S/C28H31BN4O3S/c1-6-17-8-7-9-20(12-17)32-26(34)33-21-10-11-23-18(13-21)14-24(37-23)22-15-19(16-31-25(22)30)29-35-27(2,3)28(4,5)36-29/h7-16H,6H2,1-5H3,(H2,30,31)(H2,32,33,34)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM363197
PNG
(6-amino-N-[dimethyl(oxido)- lambda4-sulfanylidene]...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc3sc(cc3c2)-c2cc(cnc2N)C(=O)N=S(C)(C)=O)c1
Show InChI InChI=1S/C24H23N5O3S2/c1-14-5-4-6-17(9-14)27-24(31)28-18-7-8-20-15(10-18)12-21(33-20)19-11-16(13-26-22(19)25)23(30)29-34(2,3)32/h4-13H,1-3H3,(H2,25,26)(H2,27,28,31)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM364994
PNG
(US10633373, Example 11 | US10669265, Example 11 | ...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3cccc(C)c3)ccc2s1
Show InChI InChI=1S/C23H20N4O3S/c1-13-4-3-5-16(8-13)26-23(29)27-17-6-7-19-14(9-17)11-20(31-19)18-10-15(22(28)30-2)12-25-21(18)24/h3-12H,1-2H3,(H2,24,25)(H2,26,27,29)
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n/an/a 20n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM363197
PNG
(6-amino-N-[dimethyl(oxido)- lambda4-sulfanylidene]...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc3sc(cc3c2)-c2cc(cnc2N)C(=O)N=S(C)(C)=O)c1
Show InChI InChI=1S/C24H23N5O3S2/c1-14-5-4-6-17(9-14)27-24(31)28-18-7-8-20-15(10-18)12-21(33-20)19-11-16(13-26-22(19)25)23(30)29-34(2,3)32/h4-13H,1-3H3,(H2,25,26)(H2,27,28,31)
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ALLERGAN, INC.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM365309
PNG
(1-{2-[2-amino-5-(4,4,5,5- tetramethyl-1,3,2- dioxa...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc3sc(cc3c2)-c2cc(cnc2N)B2OC(C)(C)C(C)(C)O2)c1
Show InChI InChI=1S/C27H29BN4O3S/c1-16-7-6-8-19(11-16)31-25(33)32-20-9-10-22-17(12-20)13-23(36-22)21-14-18(15-30-24(21)29)28-34-26(2,3)27(4,5)35-28/h6-15H,1-5H3,(H2,29,30)(H2,31,32,33)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM364995
PNG
(US10633373, Example 12 | US10669265, Example 12 | ...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccc(F)c(Cl)c3)ccc2s1
Show InChI InChI=1S/C22H16ClFN4O3S/c1-31-21(29)12-7-15(20(25)26-10-12)19-8-11-6-13(3-5-18(11)32-19)27-22(30)28-14-2-4-17(24)16(23)9-14/h2-10H,1H3,(H2,25,26)(H2,27,28,30)
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n/an/a 21n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM365216
PNG
(1-{2-[2-amino-5-(4,4,5,5- tetramethyl-1,3,2- dioxa...)
Show SMILES CC1(C)OB(OC1(C)C)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C27H25BClF3N4O3S/c1-25(2)26(3,4)39-28(38-25)15-11-18(23(33)34-13-15)22-10-14-9-16(6-8-21(14)40-22)35-24(37)36-17-5-7-20(29)19(12-17)27(30,31)32/h5-13H,1-4H3,(H2,33,34)(H2,35,36,37)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM364980
PNG
(6-amino-5-{5-[({[4-chloro-3- (trifluoromethyl)phen...)
Show SMILES CS(C)(=O)=NC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C24H19ClF3N5O3S2/c1-38(2,36)33-22(34)13-8-16(21(29)30-11-13)20-9-12-7-14(4-6-19(12)37-20)31-23(35)32-15-3-5-18(25)17(10-15)24(26,27)28/h3-11H,1-2H3,(H2,29,30)(H2,31,32,35)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM364986
PNG
(US10633373, Example 7 | US10669265, Example 7 | US...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3cccc(c3)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C23H17F3N4O3S/c1-33-21(31)13-8-17(20(27)28-11-13)19-9-12-7-16(5-6-18(12)34-19)30-22(32)29-15-4-2-3-14(10-15)23(24,25)26/h2-11H,1H3,(H2,27,28)(H2,29,30,32)
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n/an/a 22n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM364990
PNG
(US10633373, Example 8 | US10669265, Example 8 | US...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3cc(ccc3F)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C23H16F4N4O3S/c1-34-21(32)12-7-15(20(28)29-10-12)19-8-11-6-14(3-5-18(11)35-19)30-22(33)31-17-9-13(23(25,26)27)2-4-16(17)24/h2-10H,1H3,(H2,28,29)(H2,30,31,33)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM365357
PNG
(1-{4-[2-amino-5-(4,4,5,5- tetramethyl-1,3,2- dioxa...)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cc(cnc2N)B2OC(C)(C)C(C)(C)O2)c1
Show InChI InChI=1S/C25H28BFN4O3/c1-15-6-11-20(27)21(12-15)31-23(32)30-18-9-7-16(8-10-18)19-13-17(14-29-22(19)28)26-33-24(2,3)25(4,5)34-26/h6-14H,1-5H3,(H2,28,29)(H2,30,31,32)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM365338
PNG
(US10633373, Example 43 | US10669265, Example 43 | ...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)c3ccc(F)c(Cl)c3)ccc2s1
Show InChI InChI=1S/C22H15ClFN3O3S/c1-30-22(29)13-7-15(20(25)26-10-13)19-9-12-6-14(3-5-18(12)31-19)27-21(28)11-2-4-17(24)16(23)8-11/h2-10H,1H3,(H2,25,26)(H,27,28)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM365335
PNG
(US10633373, Example 40 | US10669265, Example 40 | ...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)c3cccc(C)c3)ccc2s1
Show InChI InChI=1S/C23H19N3O3S/c1-13-4-3-5-14(8-13)22(27)26-17-6-7-19-15(9-17)11-20(30-19)18-10-16(23(28)29-2)12-25-21(18)24/h3-12H,1-2H3,(H2,24,25)(H,26,27)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365356
PNG
(US10633373, Example 61 | US10669265, Example 61 | ...)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cc(cnc2N)B(O)O)c1
Show InChI InChI=1S/C19H18BFN4O3/c1-11-2-7-16(21)17(8-11)25-19(26)24-14-5-3-12(4-6-14)15-9-13(20(27)28)10-23-18(15)22/h2-10,27-28H,1H3,(H2,22,23)(H2,24,25,26)
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n/an/a 25n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM363234
PNG
(6-amino-5-[5-({[(3-chloro-4- fluorophenyl)amino]ca...)
Show SMILES CS(C)(=O)=NC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccc(F)c(Cl)c3)ccc2s1
Show InChI InChI=1S/C23H19ClFN5O3S2/c1-35(2,33)30-22(31)13-8-16(21(26)27-11-13)20-9-12-7-14(4-6-19(12)34-20)28-23(32)29-15-3-5-18(25)17(24)10-15/h3-11H,1-2H3,(H2,26,27)(H2,28,29,32)
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n/an/a 25n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365217
PNG
(1-{2-[2-amino-5-(4,4,5,5- tetramethyl-1,3,2- dioxa...)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc3sc(cc3c2)-c2cc(cnc2N)B2OC(C)(C)C(C)(C)O2)c1
Show InChI InChI=1S/C27H28BFN4O3S/c1-15-6-8-20(29)21(10-15)33-25(34)32-18-7-9-22-16(11-18)12-23(37-22)19-13-17(14-31-24(19)30)28-35-26(2,3)27(4,5)36-28/h6-14H,1-5H3,(H2,30,31)(H2,32,33,34)
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n/an/a 25n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM364995
PNG
(US10633373, Example 12 | US10669265, Example 12 | ...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccc(F)c(Cl)c3)ccc2s1
Show InChI InChI=1S/C22H16ClFN4O3S/c1-31-21(29)12-7-15(20(25)26-10-12)19-8-11-6-13(3-5-18(11)32-19)27-22(30)28-14-2-4-17(24)16(23)9-14/h2-10H,1H3,(H2,25,26)(H2,27,28,30)
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n/an/a 26n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365354
PNG
(6-amino-N-[dimethyl(oxido)- lambda4-sulfanylidene]...)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cc(cnc2N)C(=O)N=S(=O)(CCCO)CCCO)c1
Show InChI InChI=1S/C26H30FN5O5S/c1-17-4-9-22(27)23(14-17)31-26(36)30-20-7-5-18(6-8-20)21-15-19(16-29-24(21)28)25(35)32-38(37,12-2-10-33)13-3-11-34/h4-9,14-16,33-34H,2-3,10-13H2,1H3,(H2,28,29)(H2,30,31,36)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM364992
PNG
(US10633373, Example 10 | US10669265, Example 10 | ...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3cc(C)ccc3F)ccc2s1
Show InChI InChI=1S/C23H19FN4O3S/c1-12-3-5-17(24)18(7-12)28-23(30)27-15-4-6-19-13(8-15)10-20(32-19)16-9-14(22(29)31-2)11-26-21(16)25/h3-11H,1-2H3,(H2,25,26)(H2,27,28,30)
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n/an/a 27n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM364984
PNG
(6-amino-N-[dimethyl(oxido)- lambda4-sulfanylidene]...)
Show SMILES CS(C)(=O)=NC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3cc(ccc3F)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C24H19F4N5O3S2/c1-38(2,36)33-22(34)13-8-16(21(29)30-11-13)20-9-12-7-15(4-6-19(12)37-20)31-23(35)32-18-10-14(24(26,27)28)3-5-17(18)25/h3-11H,1-2H3,(H2,29,30)(H2,31,32,35)
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n/an/a 27n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM364998
PNG
(US10633373, Example 15 | US10669265, Example 15 | ...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccccc3)ccc2s1
Show InChI InChI=1S/C22H18N4O3S/c1-29-21(27)14-10-17(20(23)24-12-14)19-11-13-9-16(7-8-18(13)30-19)26-22(28)25-15-5-3-2-4-6-15/h2-12H,1H3,(H2,23,24)(H2,25,26,28)
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n/an/a 28n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM365339
PNG
(US10633373, Example 44 | US10669265, Example 44 | ...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)c3cc(ccc3F)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C23H15F4N3O3S/c1-33-22(32)12-7-16(20(28)29-10-12)19-8-11-6-14(3-5-18(11)34-19)30-21(31)15-9-13(23(25,26)27)2-4-17(15)24/h2-10H,1H3,(H2,28,29)(H,30,31)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365371
PNG
(US10633373, Example 76 | US10669265, Example 76 | ...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1ccc(NC(=O)Nc2ccccc2)cc1
Show InChI InChI=1S/C20H18N4O3/c1-27-19(25)14-11-17(18(21)22-12-14)13-7-9-16(10-8-13)24-20(26)23-15-5-3-2-4-6-15/h2-12H,1H3,(H2,21,22)(H2,23,24,26)
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n/an/a 29n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365326
PNG
(US10633373, Example 39 | US10669265, Example 39 | ...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)c3occc3C)ccc2s1
Show InChI InChI=1S/C21H17N3O4S/c1-11-5-6-28-18(11)20(25)24-14-3-4-16-12(7-14)9-17(29-16)15-8-13(21(26)27-2)10-23-19(15)22/h3-10H,1-2H3,(H2,22,23)(H,24,25)
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n/an/a 31n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365315
PNG
(6-amino-5-(5-{[4-chloro-3- (trifluoromethyl)benzoy...)
Show SMILES CS(C)(=O)=NC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)c3ccc(Cl)c(c3)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C24H18ClF3N4O3S2/c1-37(2,35)32-23(34)14-8-16(21(29)30-11-14)20-10-13-7-15(4-6-19(13)36-20)31-22(33)12-3-5-18(25)17(9-12)24(26,27)28/h3-11H,1-2H3,(H2,29,30)(H,31,33)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365366
PNG
(US10633373, Example 71 | US10669265, Example 71 | ...)
Show SMILES COC(=O)CCCCS(=O)(CCCCC(=O)OC)=NC(=O)c1cnc(N)c(c1)-c1ccc(NC(=O)Nc2cc(C)ccc2F)cc1
Show InChI InChI=1S/C32H38FN5O7S/c1-21-10-15-26(33)27(18-21)37-32(42)36-24-13-11-22(12-14-24)25-19-23(20-35-30(25)34)31(41)38-46(43,16-6-4-8-28(39)44-2)17-7-5-9-29(40)45-3/h10-15,18-20H,4-9,16-17H2,1-3H3,(H2,34,35)(H2,36,37,42)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365006
PNG
(6-amino-5-[5-({[(3- methylphenyl)amino]carbonyl} a...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc3sc(cc3c2)-c2cc(cnc2N)C(N)=O)c1
Show InChI InChI=1S/C22H19N5O2S/c1-12-3-2-4-15(7-12)26-22(29)27-16-5-6-18-13(8-16)10-19(30-18)17-9-14(21(24)28)11-25-20(17)23/h2-11H,1H3,(H2,23,25)(H2,24,28)(H2,26,27,29)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM365315
PNG
(6-amino-5-(5-{[4-chloro-3- (trifluoromethyl)benzoy...)
Show SMILES CS(C)(=O)=NC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)c3ccc(Cl)c(c3)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C24H18ClF3N4O3S2/c1-37(2,35)32-23(34)14-8-16(21(29)30-11-14)20-10-13-7-15(4-6-19(13)36-20)31-22(33)12-3-5-18(25)17(9-12)24(26,27)28/h3-11H,1-2H3,(H2,29,30)(H,31,33)
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n/an/a 36n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365307
PNG
(1-{2-[2-amino-5-(4,4,5,5- tetramethyl-1,3,2- dioxa...)
Show SMILES CC1(C)OB(OC1(C)C)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccc(F)c(Cl)c3)ccc2s1
Show InChI InChI=1S/C26H25BClFN4O3S/c1-25(2)26(3,4)36-27(35-25)15-11-18(23(30)31-13-15)22-10-14-9-16(6-8-21(14)37-22)32-24(34)33-17-5-7-20(29)19(28)12-17/h5-13H,1-4H3,(H2,30,31)(H2,32,33,34)
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n/an/a 37n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM365336
PNG
(US10633373, Example 41 | US10669265, Example 41 | ...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)c3cc(C)ccc3F)ccc2s1
Show InChI InChI=1S/C23H18FN3O3S/c1-12-3-5-18(24)16(7-12)22(28)27-15-4-6-19-13(8-15)10-20(31-19)17-9-14(23(29)30-2)11-26-21(17)25/h3-11H,1-2H3,(H2,25,26)(H,27,28)
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n/an/a 38n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365001
PNG
(6-amino-5-[5-({[(2-fluoro-5- methylphenyl)amino]ca...)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc3sc(cc3c2)-c2cc(cnc2N)C(O)=O)c1
Show InChI InChI=1S/C22H17FN4O3S/c1-11-2-4-16(23)17(6-11)27-22(30)26-14-3-5-18-12(7-14)9-19(31-18)15-8-13(21(28)29)10-25-20(15)24/h2-10H,1H3,(H2,24,25)(H,28,29)(H2,26,27,30)
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n/an/a 38n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365000
PNG
(6-amino-5-[5-({[(3-chloro-4- fluorophenyl)amino]ca...)
Show SMILES Nc1ncc(cc1-c1cc2cc(NC(=O)Nc3ccc(F)c(Cl)c3)ccc2s1)C(O)=O
Show InChI InChI=1S/C21H14ClFN4O3S/c22-15-8-13(1-3-16(15)23)27-21(30)26-12-2-4-17-10(5-12)7-18(31-17)14-6-11(20(28)29)9-25-19(14)24/h1-9H,(H2,24,25)(H,28,29)(H2,26,27,30)
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n/an/a 41n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365308
PNG
(1-{2-[2-amino-5-(4,4,5,5- tetramethyl-1,3,2- dioxa...)
Show SMILES CCc1cccc(NC(=O)Nc2ccc3sc(cc3c2)-c2cc(cnc2N)B2OC(C)(C)C(C)(C)O2)c1
Show InChI InChI=1S/C28H31BN4O3S/c1-6-17-8-7-9-20(12-17)32-26(34)33-21-10-11-23-18(13-21)14-24(37-23)22-15-19(16-31-25(22)30)29-35-27(2,3)28(4,5)36-29/h7-16H,6H2,1-5H3,(H2,30,31)(H2,32,33,34)
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n/an/a 42n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM364977
PNG
(6-amino-5-{5- [(anilinocarbonyl)amino]-1- benzothi...)
Show SMILES CS(C)(=O)=NC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccccc3)ccc2s1
Show InChI InChI=1S/C23H21N5O3S2/c1-33(2,31)28-22(29)15-11-18(21(24)25-13-15)20-12-14-10-17(8-9-19(14)32-20)27-23(30)26-16-6-4-3-5-7-16/h3-13H,1-2H3,(H2,24,25)(H2,26,27,30)
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n/an/a 42n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365367
PNG
(US10633373, Example 72 | US10669265, Example 72 | ...)
Show SMILES COC(=O)CCCCS(=O)(CCCCC(=O)OC)=NC(=O)c1cnc(N)c(c1)-c1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1
Show InChI InChI=1S/C32H36F3N5O7S/c1-46-27(41)10-3-5-16-48(45,17-6-4-11-28(42)47-2)40-30(43)22-18-26(29(36)37-20-22)21-12-14-24(15-13-21)38-31(44)39-25-9-7-8-23(19-25)32(33,34)35/h7-9,12-15,18-20H,3-6,10-11,16-17H2,1-2H3,(H2,36,37)(H2,38,39,44)
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n/an/a 42n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM365312
PNG
(US10633373, Example 31 | US10669265, Example 31 | ...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc3sc(cc3c2)-c2cc(cnc2N)B(O)O)c1
Show InChI InChI=1S/C21H19BN4O3S/c1-12-3-2-4-15(7-12)25-21(27)26-16-5-6-18-13(8-16)9-19(30-18)17-10-14(22(28)29)11-24-20(17)23/h2-11,28-29H,1H3,(H2,23,24)(H2,25,26,27)
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n/an/a 42n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM364991
PNG
(US10633373, Example 9 | US10669265, Example 9 | US...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C23H16ClF3N4O3S/c1-34-21(32)12-7-15(20(28)29-10-12)19-8-11-6-13(3-5-18(11)35-19)30-22(33)31-14-2-4-17(24)16(9-14)23(25,26)27/h2-10H,1H3,(H2,28,29)(H2,30,31,33)
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n/an/a 45n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365318
PNG
(6-amino-N-[dimethyl(oxido)- lambda4-sulfanylidene]...)
Show SMILES Cc1ccc(F)c(c1)C(=O)Nc1ccc2sc(cc2c1)-c1cc(cnc1N)C(=O)N=S(C)(C)=O
Show InChI InChI=1S/C24H21FN4O3S2/c1-13-4-6-19(25)17(8-13)24(31)28-16-5-7-20-14(9-16)11-21(33-20)18-10-15(12-27-22(18)26)23(30)29-34(2,3)32/h4-12H,1-3H3,(H2,26,27)(H,28,31)
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n/an/a 45n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM364996
PNG
(US10633373, Example 13 | US10669265, Example 13 | ...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccc(C)cc3)ccc2s1
Show InChI InChI=1S/C23H20N4O3S/c1-13-3-5-16(6-4-13)26-23(29)27-17-7-8-19-14(9-17)11-20(31-19)18-10-15(22(28)30-2)12-25-21(18)24/h3-12H,1-2H3,(H2,24,25)(H2,26,27,29)
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n/an/a 45n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365318
PNG
(6-amino-N-[dimethyl(oxido)- lambda4-sulfanylidene]...)
Show SMILES Cc1ccc(F)c(c1)C(=O)Nc1ccc2sc(cc2c1)-c1cc(cnc1N)C(=O)N=S(C)(C)=O
Show InChI InChI=1S/C24H21FN4O3S2/c1-13-4-6-19(25)17(8-13)24(31)28-16-5-7-20-14(9-16)11-21(33-20)18-10-15(12-27-22(18)26)23(30)29-34(2,3)32/h4-12H,1-3H3,(H2,26,27)(H,28,31)
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n/an/a 50n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365320
PNG
(6-amino-5-[5-(benzoylamino)- 1-benzothien-2-yl]-N...)
Show SMILES CS(C)(=O)=NC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)c3ccccc3)ccc2s1
Show InChI InChI=1S/C23H20N4O3S2/c1-32(2,30)27-23(29)16-11-18(21(24)25-13-16)20-12-15-10-17(8-9-19(15)31-20)26-22(28)14-6-4-3-5-7-14/h3-13H,1-2H3,(H2,24,25)(H,26,28)
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n/an/a 51n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365357
PNG
(1-{4-[2-amino-5-(4,4,5,5- tetramethyl-1,3,2- dioxa...)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cc(cnc2N)B2OC(C)(C)C(C)(C)O2)c1
Show InChI InChI=1S/C25H28BFN4O3/c1-15-6-11-20(27)21(12-15)31-23(32)30-18-9-7-16(8-10-18)19-13-17(14-29-22(19)28)26-33-24(2,3)25(4,5)34-26/h6-14H,1-5H3,(H2,28,29)(H2,30,31,32)
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n/an/a 53n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365321
PNG
(6-amino-N-[dimethyl(oxido)- lambda4-sulfanylidene]...)
Show SMILES Cc1cccc(c1)C(=O)Nc1ccc2sc(cc2c1)-c1cc(cnc1N)C(=O)N=S(C)(C)=O
Show InChI InChI=1S/C24H22N4O3S2/c1-14-5-4-6-15(9-14)23(29)27-18-7-8-20-16(10-18)12-21(32-20)19-11-17(13-26-22(19)25)24(30)28-33(2,3)31/h4-13H,1-3H3,(H2,25,26)(H,27,29)
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n/an/a 53n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365309
PNG
(1-{2-[2-amino-5-(4,4,5,5- tetramethyl-1,3,2- dioxa...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc3sc(cc3c2)-c2cc(cnc2N)B2OC(C)(C)C(C)(C)O2)c1
Show InChI InChI=1S/C27H29BN4O3S/c1-16-7-6-8-19(11-16)31-25(33)32-20-9-10-22-17(12-20)13-23(36-22)21-14-18(15-30-24(21)29)28-34-26(2,3)27(4,5)35-28/h6-15H,1-5H3,(H2,29,30)(H2,31,32,33)
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n/an/a 54n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365335
PNG
(US10633373, Example 40 | US10669265, Example 40 | ...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)c3cccc(C)c3)ccc2s1
Show InChI InChI=1S/C23H19N3O3S/c1-13-4-3-5-14(8-13)22(27)26-17-6-7-19-15(9-17)11-20(30-19)18-10-16(23(28)29-2)12-25-21(18)24/h3-12H,1-2H3,(H2,24,25)(H,26,27)
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n/an/a 57n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365359
PNG
(US10633373, Example 64 | US10669265, Example 64 | ...)
Show SMILES COP(=O)(OC)c1cnc(N)c(c1)-c1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1
Show InChI InChI=1S/C21H20F3N4O4P/c1-31-33(30,32-2)17-11-18(19(25)26-12-17)13-6-8-15(9-7-13)27-20(29)28-16-5-3-4-14(10-16)21(22,23)24/h3-12H,1-2H3,(H2,25,26)(H2,27,28,29)
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n/an/a 57n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM365356
PNG
(US10633373, Example 61 | US10669265, Example 61 | ...)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cc(cnc2N)B(O)O)c1
Show InChI InChI=1S/C19H18BFN4O3/c1-11-2-7-16(21)17(8-11)25-19(26)24-14-5-3-12(4-6-14)15-9-13(20(27)28)10-23-18(15)22/h2-10,27-28H,1H3,(H2,22,23)(H2,24,25,26)
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n/an/a 58n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM365326
PNG
(US10633373, Example 39 | US10669265, Example 39 | ...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)c3occc3C)ccc2s1
Show InChI InChI=1S/C21H17N3O4S/c1-11-5-6-28-18(11)20(25)24-14-3-4-16-12(7-14)9-17(29-16)15-8-13(21(26)27-2)10-23-19(15)22/h3-10H,1-2H3,(H2,22,23)(H,24,25)
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n/an/a 61n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM364991
PNG
(US10633373, Example 9 | US10669265, Example 9 | US...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C23H16ClF3N4O3S/c1-34-21(32)12-7-15(20(28)29-10-12)19-8-11-6-13(3-5-18(11)35-19)30-22(33)31-14-2-4-17(24)16(9-14)23(25,26)27/h2-10H,1H3,(H2,28,29)(H2,30,31,33)
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n/an/a 63n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM364977
PNG
(6-amino-5-{5- [(anilinocarbonyl)amino]-1- benzothi...)
Show SMILES CS(C)(=O)=NC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccccc3)ccc2s1
Show InChI InChI=1S/C23H21N5O3S2/c1-33(2,31)28-22(29)15-11-18(21(24)25-13-15)20-12-14-10-17(8-9-19(14)32-20)27-23(30)26-16-6-4-3-5-7-16/h3-13H,1-2H3,(H2,24,25)(H2,26,27,30)
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n/an/a 68n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))
BDBM364980
PNG
(6-amino-5-{5-[({[4-chloro-3- (trifluoromethyl)phen...)
Show SMILES CS(C)(=O)=NC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C24H19ClF3N5O3S2/c1-38(2,36)33-22(34)13-8-16(21(29)30-11-13)20-9-12-7-14(4-6-19(12)37-20)31-23(35)32-15-3-5-18(25)17(10-15)24(26,27)28/h3-11H,1-2H3,(H2,29,30)(H2,31,32,35)
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n/an/a 69n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM364977
PNG
(6-amino-5-{5- [(anilinocarbonyl)amino]-1- benzothi...)
Show SMILES CS(C)(=O)=NC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccccc3)ccc2s1
Show InChI InChI=1S/C23H21N5O3S2/c1-33(2,31)28-22(29)15-11-18(21(24)25-13-15)20-12-14-10-17(8-9-19(14)32-20)27-23(30)26-16-6-4-3-5-7-16/h3-13H,1-2H3,(H2,24,25)(H2,26,27,30)
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n/an/a 73n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM364997
PNG
(US10633373, Example 14 | US10669265, Example 14 | ...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccccc3F)ccc2s1
Show InChI InChI=1S/C22H17FN4O3S/c1-30-21(28)13-9-15(20(24)25-11-13)19-10-12-8-14(6-7-18(12)31-19)26-22(29)27-17-5-3-2-4-16(17)23/h2-11H,1H3,(H2,24,25)(H2,26,27,29)
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n/an/a 81n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM365360
PNG
(US10633373, Example 65 | US10669265, Example 65 | ...)
Show SMILES CCOP(=O)(OCC)c1cnc(N)c(c1)-c1ccc(NC(=O)Nc2cc(C)ccc2F)cc1
Show InChI InChI=1S/C23H26FN4O4P/c1-4-31-33(30,32-5-2)18-13-19(22(25)26-14-18)16-7-9-17(10-8-16)27-23(29)28-21-12-15(3)6-11-20(21)24/h6-14H,4-5H2,1-3H3,(H2,25,26)(H2,27,28,29)
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n/an/a 82n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM365364
PNG
(6-amino-N-[bis(3- hydroxypropyl)(oxido)-lambda6- s...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cc(cnc2N)C(=O)N=S(=O)(CCCO)CCCO)c1
Show InChI InChI=1S/C26H31N5O5S/c1-18-5-2-6-22(15-18)30-26(35)29-21-9-7-19(8-10-21)23-16-20(17-28-24(23)27)25(34)31-37(36,13-3-11-32)14-4-12-33/h2,5-10,15-17,32-33H,3-4,11-14H2,1H3,(H2,27,28)(H2,29,30,35)
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n/an/a 83n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM365366
PNG
(US10633373, Example 71 | US10669265, Example 71 | ...)
Show SMILES COC(=O)CCCCS(=O)(CCCCC(=O)OC)=NC(=O)c1cnc(N)c(c1)-c1ccc(NC(=O)Nc2cc(C)ccc2F)cc1
Show InChI InChI=1S/C32H38FN5O7S/c1-21-10-15-26(33)27(18-21)37-32(42)36-24-13-11-22(12-14-24)25-19-23(20-35-30(25)34)31(41)38-46(43,16-6-4-8-28(39)44-2)17-7-5-9-29(40)45-3/h10-15,18-20H,4-9,16-17H2,1-3H3,(H2,34,35)(H2,36,37,42)
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n/an/a 88n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365312
PNG
(US10633373, Example 31 | US10669265, Example 31 | ...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc3sc(cc3c2)-c2cc(cnc2N)B(O)O)c1
Show InChI InChI=1S/C21H19BN4O3S/c1-12-3-2-4-15(7-12)25-21(27)26-16-5-6-18-13(8-16)9-19(30-18)17-10-14(22(28)29)11-24-20(17)23/h2-11,28-29H,1H3,(H2,23,24)(H2,25,26,27)
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n/an/a 93n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365360
PNG
(US10633373, Example 65 | US10669265, Example 65 | ...)
Show SMILES CCOP(=O)(OCC)c1cnc(N)c(c1)-c1ccc(NC(=O)Nc2cc(C)ccc2F)cc1
Show InChI InChI=1S/C23H26FN4O4P/c1-4-31-33(30,32-5-2)18-13-19(22(25)26-14-18)16-7-9-17(10-8-16)27-23(29)28-21-12-15(3)6-11-20(21)24/h6-14H,4-5H2,1-3H3,(H2,25,26)(H2,27,28,29)
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n/an/a 99n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM365354
PNG
(6-amino-N-[dimethyl(oxido)- lambda4-sulfanylidene]...)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cc(cnc2N)C(=O)N=S(=O)(CCCO)CCCO)c1
Show InChI InChI=1S/C26H30FN5O5S/c1-17-4-9-22(27)23(14-17)31-26(36)30-20-7-5-18(6-8-20)21-15-19(16-29-24(21)28)25(35)32-38(37,12-2-10-33)13-3-11-34/h4-9,14-16,33-34H,2-3,10-13H2,1H3,(H2,28,29)(H2,30,31,36)
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n/an/a 100n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365361
PNG
(US10633373, Example 66 | US10669265, Example 66 | ...)
Show SMILES COP(=O)(OC)c1cnc(N)c(c1)-c1ccc(NC(=O)Nc2cc(ccc2F)C(F)(F)F)cc1
Show InChI InChI=1S/C21H19F4N4O4P/c1-32-34(31,33-2)15-10-16(19(26)27-11-15)12-3-6-14(7-4-12)28-20(30)29-18-9-13(21(23,24)25)5-8-17(18)22/h3-11H,1-2H3,(H2,26,27)(H2,28,29,30)
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n/an/a 115n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365008
PNG
(US10633373, Example 21 | US10669265, Example 21 | ...)
Show SMILES COC(=O)CCCNC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3cccc(C)c3)ccc2s1
Show InChI InChI=1S/C27H27N5O4S/c1-16-5-3-6-19(11-16)31-27(35)32-20-8-9-22-17(12-20)14-23(37-22)21-13-18(15-30-25(21)28)26(34)29-10-4-7-24(33)36-2/h3,5-6,8-9,11-15H,4,7,10H2,1-2H3,(H2,28,30)(H,29,34)(H2,31,32,35)
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n/an/a 118n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365005
PNG
(6-amino-5-[5-({[(3- methylphenyl)amino]carbonyl} a...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc3sc(cc3c2)-c2cc(cnc2N)C(O)=O)c1
Show InChI InChI=1S/C22H18N4O3S/c1-12-3-2-4-15(7-12)25-22(29)26-16-5-6-18-13(8-16)10-19(30-18)17-9-14(21(27)28)11-24-20(17)23/h2-11H,1H3,(H2,23,24)(H,27,28)(H2,25,26,29)
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n/an/a 120n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM365322
PNG
(6-amino-N-[dimethyl(oxido)- lambda4-sulfanylidene]...)
Show SMILES CS(C)(=O)=NC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)c3cc(ccc3F)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C24H18F4N4O3S2/c1-37(2,35)32-22(33)13-8-17(21(29)30-11-13)20-9-12-7-15(4-6-19(12)36-20)31-23(34)16-10-14(24(26,27)28)3-5-18(16)25/h3-11H,1-2H3,(H2,29,30)(H,31,34)
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n/an/a 128n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM365311
PNG
(1-{2-[2-amino-5-(4,4,5,5- tetramethyl-1,3,2- dioxa...)
Show SMILES CC1(C)OB(OC1(C)C)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccccc3)ccc2s1
Show InChI InChI=1S/C26H27BN4O3S/c1-25(2)26(3,4)34-27(33-25)17-14-20(23(28)29-15-17)22-13-16-12-19(10-11-21(16)35-22)31-24(32)30-18-8-6-5-7-9-18/h5-15H,1-4H3,(H2,28,29)(H2,30,31,32)
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n/an/a 130n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM365321
PNG
(6-amino-N-[dimethyl(oxido)- lambda4-sulfanylidene]...)
Show SMILES Cc1cccc(c1)C(=O)Nc1ccc2sc(cc2c1)-c1cc(cnc1N)C(=O)N=S(C)(C)=O
Show InChI InChI=1S/C24H22N4O3S2/c1-14-5-4-6-15(9-14)23(29)27-18-7-8-20-16(10-18)12-21(32-20)19-11-17(13-26-22(19)25)24(30)28-33(2,3)31/h4-13H,1-3H3,(H2,25,26)(H,27,29)
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n/an/a 131n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365011
PNG
(US10633373, Example 22 | US10669265, Example 22 | ...)
Show SMILES COC(=O)CCCCCNC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3cccc(C)c3)ccc2s1
Show InChI InChI=1S/C29H31N5O4S/c1-18-7-6-8-21(13-18)33-29(37)34-22-10-11-24-19(14-22)16-25(39-24)23-15-20(17-32-27(23)30)28(36)31-12-5-3-4-9-26(35)38-2/h6-8,10-11,13-17H,3-5,9,12H2,1-2H3,(H2,30,32)(H,31,36)(H2,33,34,37)
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n/an/a 132n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365362
PNG
(US10633373, Example 67 | US10669265, Example 67 | ...)
Show SMILES COP(=O)(OC)c1cnc(N)c(c1)-c1ccc(NC(=O)Nc2cc(C)ccc2F)cc1
Show InChI InChI=1S/C21H22FN4O4P/c1-13-4-9-18(22)19(10-13)26-21(27)25-15-7-5-14(6-8-15)17-11-16(12-24-20(17)23)31(28,29-2)30-3/h4-12H,1-3H3,(H2,23,24)(H2,25,26,27)
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n/an/a 133n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM364998
PNG
(US10633373, Example 15 | US10669265, Example 15 | ...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccccc3)ccc2s1
Show InChI InChI=1S/C22H18N4O3S/c1-29-21(27)14-10-17(20(23)24-12-14)19-11-13-9-16(7-8-18(13)30-19)26-22(28)25-15-5-3-2-4-6-15/h2-12H,1H3,(H2,23,24)(H2,25,26,28)
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n/an/a 137n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM365313
PNG
((6-amino-5-{5- [(anilinocarbonyl)amino]-1- benzoth...)
Show SMILES Nc1ncc(cc1-c1cc2cc(NC(=O)Nc3ccccc3)ccc2s1)B(O)O
Show InChI InChI=1S/C20H17BN4O3S/c22-19-16(10-13(11-23-19)21(27)28)18-9-12-8-15(6-7-17(12)29-18)25-20(26)24-14-4-2-1-3-5-14/h1-11,27-28H,(H2,22,23)(H2,24,25,26)
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n/an/a 138n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM365365
PNG
(US10633373, Example 70 | US10669265, Example 70 | ...)
Show SMILES COC(=O)CCCCS(=O)(CCCCC(=O)OC)=NC(=O)c1cnc(N)c(c1)-c1ccc(NC(=O)Nc2cccc(C)c2)cc1
Show InChI InChI=1S/C32H39N5O7S/c1-22-9-8-10-26(19-22)36-32(41)35-25-15-13-23(14-16-25)27-20-24(21-34-30(27)33)31(40)37-45(42,17-6-4-11-28(38)43-2)18-7-5-12-29(39)44-3/h8-10,13-16,19-21H,4-7,11-12,17-18H2,1-3H3,(H2,33,34)(H2,35,36,41)
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n/an/a 138n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))
BDBM364984
PNG
(6-amino-N-[dimethyl(oxido)- lambda4-sulfanylidene]...)
Show SMILES CS(C)(=O)=NC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3cc(ccc3F)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C24H19F4N5O3S2/c1-38(2,36)33-22(34)13-8-16(21(29)30-11-13)20-9-12-7-15(4-6-19(12)37-20)31-23(35)32-18-10-14(24(26,27)28)3-5-17(18)25/h3-11H,1-2H3,(H2,29,30)(H2,31,32,35)
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ALLERGAN, INC.

US Patent


Assay Description
Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365322
PNG
(6-amino-N-[dimethyl(oxido)- lambda4-sulfanylidene]...)
Show SMILES CS(C)(=O)=NC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)c3cc(ccc3F)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C24H18F4N4O3S2/c1-37(2,35)32-22(33)13-8-17(21(29)30-11-13)20-9-12-7-15(4-6-19(12)36-20)31-23(34)16-10-14(24(26,27)28)3-5-18(16)25/h3-11H,1-2H3,(H2,29,30)(H,31,34)
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n/an/a 178n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365336
PNG
(US10633373, Example 41 | US10669265, Example 41 | ...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)c3cc(C)ccc3F)ccc2s1
Show InChI InChI=1S/C23H18FN3O3S/c1-12-3-5-18(24)16(7-12)22(28)27-15-4-6-19-13(8-15)10-20(31-19)17-9-14(23(29)30-2)11-26-21(17)25/h3-11H,1-2H3,(H2,25,26)(H,27,28)
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n/an/a 199n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365358
PNG
(1-{4-[2-amino-5-(4,4,5,5- tetramethyl-1,3,2- dioxa...)
Show SMILES CC1(C)OB(OC1(C)C)c1cnc(N)c(c1)-c1ccc(NC(=O)Nc2ccccc2)cc1
Show InChI InChI=1S/C24H27BN4O3/c1-23(2)24(3,4)32-25(31-23)17-14-20(21(26)27-15-17)16-10-12-19(13-11-16)29-22(30)28-18-8-6-5-7-9-18/h5-15H,1-4H3,(H2,26,27)(H2,28,29,30)
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n/an/a 206n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365337
PNG
(6-amino-5-[5-[5 (benzoylamino)-1-benzothien- 2-yl]...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)c3ccccc3)ccc2s1
Show InChI InChI=1S/C22H17N3O3S/c1-28-22(27)15-10-17(20(23)24-12-15)19-11-14-9-16(7-8-18(14)29-19)25-21(26)13-5-3-2-4-6-13/h2-12H,1H3,(H2,23,24)(H,25,26)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM365318
PNG
(6-amino-N-[dimethyl(oxido)- lambda4-sulfanylidene]...)
Show SMILES Cc1ccc(F)c(c1)C(=O)Nc1ccc2sc(cc2c1)-c1cc(cnc1N)C(=O)N=S(C)(C)=O
Show InChI InChI=1S/C24H21FN4O3S2/c1-13-4-6-19(25)17(8-13)24(31)28-16-5-7-20-14(9-16)11-21(33-20)18-10-15(12-27-22(18)26)23(30)29-34(2,3)32/h4-12H,1-3H3,(H2,26,27)(H,28,31)
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n/an/a 258n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365338
PNG
(US10633373, Example 43 | US10669265, Example 43 | ...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)c3ccc(F)c(Cl)c3)ccc2s1
Show InChI InChI=1S/C22H15ClFN3O3S/c1-30-22(29)13-7-15(20(25)26-10-13)19-9-12-6-14(3-5-18(12)31-19)27-21(28)11-2-4-17(24)16(23)8-11/h2-10H,1H3,(H2,25,26)(H,27,28)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365315
PNG
(6-amino-5-(5-{[4-chloro-3- (trifluoromethyl)benzoy...)
Show SMILES CS(C)(=O)=NC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)c3ccc(Cl)c(c3)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C24H18ClF3N4O3S2/c1-37(2,35)32-23(34)14-8-16(21(29)30-11-14)20-10-13-7-15(4-6-19(13)36-20)31-22(33)12-3-5-18(25)17(9-12)24(26,27)28/h3-11H,1-2H3,(H2,29,30)(H,31,33)
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n/an/a 277n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365311
PNG
(1-{2-[2-amino-5-(4,4,5,5- tetramethyl-1,3,2- dioxa...)
Show SMILES CC1(C)OB(OC1(C)C)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccccc3)ccc2s1
Show InChI InChI=1S/C26H27BN4O3S/c1-25(2)26(3,4)34-27(33-25)17-14-20(23(28)29-15-17)22-13-16-12-19(10-11-21(16)35-22)31-24(32)30-18-8-6-5-7-9-18/h5-15H,1-4H3,(H2,28,29)(H2,30,31,32)
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n/an/a 301n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM364994
PNG
(US10633373, Example 11 | US10669265, Example 11 | ...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3cccc(C)c3)ccc2s1
Show InChI InChI=1S/C23H20N4O3S/c1-13-4-3-5-16(8-13)26-23(29)27-17-6-7-19-14(9-17)11-20(31-19)18-10-15(22(28)30-2)12-25-21(18)24/h3-12H,1-2H3,(H2,24,25)(H2,26,27,29)
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n/an/a 328n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM364995
PNG
(US10633373, Example 12 | US10669265, Example 12 | ...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccc(F)c(Cl)c3)ccc2s1
Show InChI InChI=1S/C22H16ClFN4O3S/c1-31-21(29)12-7-15(20(25)26-10-12)19-8-11-6-13(3-5-18(11)32-19)27-22(30)28-14-2-4-17(24)16(23)9-14/h2-10H,1H3,(H2,25,26)(H2,27,28,30)
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n/an/a 355n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365313
PNG
((6-amino-5-{5- [(anilinocarbonyl)amino]-1- benzoth...)
Show SMILES Nc1ncc(cc1-c1cc2cc(NC(=O)Nc3ccccc3)ccc2s1)B(O)O
Show InChI InChI=1S/C20H17BN4O3S/c22-19-16(10-13(11-23-19)21(27)28)18-9-12-8-15(6-7-17(12)29-18)25-20(26)24-14-4-2-1-3-5-14/h1-11,27-28H,(H2,22,23)(H2,24,25,26)
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n/an/a 378n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))
BDBM365353
PNG
(5-{5-[({[4-chloro-3- (trifluoromethyl)phenyl]amino...)
Show SMILES CS(C)(=O)=NC(=O)c1cncc(c1)-c1cc2cc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C24H18ClF3N4O3S2/c1-37(2,35)32-22(33)15-7-14(11-29-12-15)21-9-13-8-16(4-6-20(13)36-21)30-23(34)31-17-3-5-19(25)18(10-17)24(26,27)28/h3-12H,1-2H3,(H2,30,31,34)
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n/an/a 390n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM365005
PNG
(6-amino-5-[5-({[(3- methylphenyl)amino]carbonyl} a...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc3sc(cc3c2)-c2cc(cnc2N)C(O)=O)c1
Show InChI InChI=1S/C22H18N4O3S/c1-12-3-2-4-15(7-12)25-22(29)26-16-5-6-18-13(8-16)10-19(30-18)17-9-14(21(27)28)11-24-20(17)23/h2-11H,1H3,(H2,23,24)(H,27,28)(H2,25,26,29)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM365314
PNG
(6-amino-N-[dimethyl(oxido)- lambda4-sulfanylidene]...)
Show SMILES Cc1ccoc1C(=O)Nc1ccc2sc(cc2c1)-c1cc(cnc1N)C(=O)N=S(C)(C)=O
Show InChI InChI=1S/C22H20N4O4S2/c1-12-6-7-30-19(12)22(28)25-15-4-5-17-13(8-15)10-18(31-17)16-9-14(11-24-20(16)23)21(27)26-32(2,3)29/h4-11H,1-3H3,(H2,23,24)(H,25,28)
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n/an/a 457n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM365337
PNG
(6-amino-5-[5-[5 (benzoylamino)-1-benzothien- 2-yl]...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)c3ccccc3)ccc2s1
Show InChI InChI=1S/C22H17N3O3S/c1-28-22(27)15-10-17(20(23)24-12-15)19-11-14-9-16(7-8-18(14)29-19)25-21(26)13-5-3-2-4-6-13/h2-12H,1H3,(H2,23,24)(H,25,26)
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n/an/a 503n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))
BDBM365352
PNG
(N-[dimethyl(oxido)-lambda4- sulfanylidene]-5-{5-[(...)
Show SMILES CS(C)(=O)=NC(=O)c1cncc(c1)-c1cc2cc(NC(=O)Nc3cc(ccc3F)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C24H18F4N4O3S2/c1-37(2,35)32-22(33)15-7-14(11-29-12-15)21-9-13-8-17(4-6-20(13)36-21)30-23(34)31-19-10-16(24(26,27)28)3-5-18(19)25/h3-12H,1-2H3,(H2,30,31,34)
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n/an/a 551n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365363
PNG
(US10633373, Example 68 | US10669265, Example 68 | ...)
Show SMILES COP(=O)(OC)c1cnc(N)c(c1)-c1ccc(NC(=O)Nc2ccccc2)cc1
Show InChI InChI=1S/C20H21N4O4P/c1-27-29(26,28-2)17-12-18(19(21)22-13-17)14-8-10-16(11-9-14)24-20(25)23-15-6-4-3-5-7-15/h3-13H,1-2H3,(H2,21,22)(H2,23,24,25)
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n/an/a 891n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365339
PNG
(US10633373, Example 44 | US10669265, Example 44 | ...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)c3cc(ccc3F)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C23H15F4N3O3S/c1-33-22(32)12-7-16(20(28)29-10-12)19-8-11-6-14(3-5-18(11)34-19)30-21(31)15-9-13(23(25,26)27)2-4-17(15)24/h2-10H,1H3,(H2,28,29)(H,30,31)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM365340
PNG
(US10633373, Example 45 | US10669265, Example 45 | ...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)c3cc4ccccc4o3)ccc2s1
Show InChI InChI=1S/C24H17N3O4S/c1-30-24(29)15-9-17(22(25)26-12-15)21-11-14-8-16(6-7-20(14)32-21)27-23(28)19-10-13-4-2-3-5-18(13)31-19/h2-12H,1H3,(H2,25,26)(H,27,28)
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n/an/a 936n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM364996
PNG
(US10633373, Example 13 | US10669265, Example 13 | ...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccc(C)cc3)ccc2s1
Show InChI InChI=1S/C23H20N4O3S/c1-13-3-5-16(6-4-13)26-23(29)27-17-7-8-19-14(9-17)11-20(31-19)18-10-15(22(28)30-2)12-25-21(18)24/h3-12H,1-2H3,(H2,24,25)(H2,26,27,29)
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US Patent
n/an/a 941n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365322
PNG
(6-amino-N-[dimethyl(oxido)- lambda4-sulfanylidene]...)
Show SMILES CS(C)(=O)=NC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)c3cc(ccc3F)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C24H18F4N4O3S2/c1-37(2,35)32-22(33)13-8-17(21(29)30-11-13)20-9-12-7-15(4-6-19(12)36-20)31-23(34)16-10-14(24(26,27)28)3-5-18(16)25/h3-11H,1-2H3,(H2,29,30)(H,31,34)
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US Patent
n/an/a 1.02E+3n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365343
PNG
(N-[2-(2-aminopyridin-3-yl)-1- benzothien-5-yl]-3- ...)
Show SMILES Cc1cccc(c1)C(=O)Nc1ccc2sc(cc2c1)-c1cccnc1N
Show InChI InChI=1S/C21H17N3OS/c1-13-4-2-5-14(10-13)21(25)24-16-7-8-18-15(11-16)12-19(26-18)17-6-3-9-23-20(17)22/h2-12H,1H3,(H2,22,23)(H,24,25)
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n/an/a 1.17E+3n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM365343
PNG
(N-[2-(2-aminopyridin-3-yl)-1- benzothien-5-yl]-3- ...)
Show SMILES Cc1cccc(c1)C(=O)Nc1ccc2sc(cc2c1)-c1cccnc1N
Show InChI InChI=1S/C21H17N3OS/c1-13-4-2-5-14(10-13)21(25)24-16-7-8-18-15(11-16)12-19(26-18)17-6-3-9-23-20(17)22/h2-12H,1H3,(H2,22,23)(H,24,25)
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n/an/a 1.28E+3n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM364998
PNG
(US10633373, Example 15 | US10669265, Example 15 | ...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccccc3)ccc2s1
Show InChI InChI=1S/C22H18N4O3S/c1-29-21(27)14-10-17(20(23)24-12-14)19-11-13-9-16(7-8-18(13)30-19)26-22(28)25-15-5-3-2-4-6-15/h2-12H,1H3,(H2,23,24)(H2,25,26,28)
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US Patent
n/an/a 1.35E+3n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365345
PNG
(N-[2-(2-aminopyridin-3-yl)-1- benzothien-5-yl]benz...)
Show SMILES Nc1ncccc1-c1cc2cc(NC(=O)c3ccccc3)ccc2s1
Show InChI InChI=1S/C20H15N3OS/c21-19-16(7-4-10-22-19)18-12-14-11-15(8-9-17(14)25-18)23-20(24)13-5-2-1-3-6-13/h1-12H,(H2,21,22)(H,23,24)
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n/an/a 1.49E+3n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM364997
PNG
(US10633373, Example 14 | US10669265, Example 14 | ...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccccc3F)ccc2s1
Show InChI InChI=1S/C22H17FN4O3S/c1-30-21(28)13-9-15(20(24)25-11-13)19-10-12-8-14(6-7-18(12)31-19)26-22(29)27-17-5-3-2-4-16(17)23/h2-11H,1H3,(H2,24,25)(H2,26,27,29)
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US Patent
n/an/a 1.60E+3n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365347
PNG
(2-(2-aminopyridin-3-yl)-N-(3- methylphenyl)-1- ben...)
Show SMILES Cc1cccc(NC(=O)c2ccc3sc(cc3c2)-c2cccnc2N)c1
Show InChI InChI=1S/C21H17N3OS/c1-13-4-2-5-16(10-13)24-21(25)14-7-8-18-15(11-14)12-19(26-18)17-6-3-9-23-20(17)22/h2-12H,1H3,(H2,22,23)(H,24,25)
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n/an/a 3.57E+3n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM365347
PNG
(2-(2-aminopyridin-3-yl)-N-(3- methylphenyl)-1- ben...)
Show SMILES Cc1cccc(NC(=O)c2ccc3sc(cc3c2)-c2cccnc2N)c1
Show InChI InChI=1S/C21H17N3OS/c1-13-4-2-5-16(10-13)24-21(25)14-7-8-18-15(11-14)12-19(26-18)17-6-3-9-23-20(17)22/h2-12H,1H3,(H2,22,23)(H,24,25)
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n/an/a>1.00E+4n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US10669265 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%