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Patent code US10669267

Compile Data Set for Download or QSAR
Found 65 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM446067
PNG
(2-chloro-6-fluoro-N-(2-{4-[(3-fluorophenyl)methoxy...)
Show SMILES Cc1ncsc1C(CNC(=O)c1c(F)cccc1Cl)N1CCC(CC1)OCc1cccc(F)c1
Show InChI InChI=1S/C25H26ClF2N3O2S/c1-16-24(34-15-30-16)22(13-29-25(32)23-20(26)6-3-7-21(23)28)31-10-8-19(9-11-31)33-14-17-4-2-5-18(27)12-17/h2-7,12,15,19,22H,8-11,13-14H2,1H3,(H,29,32)
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n/an/a 5.95n/an/an/an/an/an/a



Axxam S.P.A.

US Patent


Assay Description
In order to directly monitor the block of P2X7 channel, an electrophysiological assay was developed and implemented on the QPatch16X automated electr...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM446076
PNG
(N-(2-{4-[(3-fluorophenyl)methoxy]piperidin-1-yl}-2...)
Show SMILES Cc1ncsc1C(CNC(=O)c1cccc2ncccc12)N1CCC(CC1)OCc1cccc(F)c1
Show InChI InChI=1S/C28H29FN4O2S/c1-19-27(36-18-32-19)26(16-31-28(34)24-7-3-9-25-23(24)8-4-12-30-25)33-13-10-22(11-14-33)35-17-20-5-2-6-21(29)15-20/h2-9,12,15,18,22,26H,10-11,13-14,16-17H2,1H3,(H,31,34)
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n/an/a 11.6n/an/an/an/an/an/a



Axxam S.P.A.

US Patent


Assay Description
In order to directly monitor the block of P2X7 channel, an electrophysiological assay was developed and implemented on the QPatch16X automated electr...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM446071
PNG
(2-chloro-6-fluoro-N-{2-[4-(3-fluorophenoxy)piperid...)
Show SMILES Cc1ncsc1C(CNC(=O)c1c(F)cccc1Cl)N1CCC(CC1)Oc1cccc(F)c1
Show InChI InChI=1S/C24H24ClF2N3O2S/c1-15-23(33-14-29-15)21(13-28-24(31)22-19(25)6-3-7-20(22)27)30-10-8-17(9-11-30)32-18-5-2-4-16(26)12-18/h2-7,12,14,17,21H,8-11,13H2,1H3,(H,28,31)
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n/an/a 23.6n/an/an/an/an/an/a



Axxam S.P.A.

US Patent


Assay Description
In order to directly monitor the block of P2X7 channel, an electrophysiological assay was developed and implemented on the QPatch16X automated electr...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM446079
PNG
(N-{2-[4-(4-fluorophenoxy)piperidin-1-yl]-2-(4-meth...)
Show SMILES Cc1ncsc1C(CNC(=O)c1cccc2ncccc12)N1CCC(CC1)Oc1ccc(F)cc1
Show InChI InChI=1S/C27H27FN4O2S/c1-18-26(35-17-31-18)25(16-30-27(33)23-4-2-6-24-22(23)5-3-13-29-24)32-14-11-21(12-15-32)34-20-9-7-19(28)8-10-20/h2-10,13,17,21,25H,11-12,14-16H2,1H3,(H,30,33)
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n/an/a 23.9n/an/an/an/an/an/a



Axxam S.P.A.

US Patent


Assay Description
In order to directly monitor the block of P2X7 channel, an electrophysiological assay was developed and implemented on the QPatch16X automated electr...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM446074
PNG
(2-chloro-N-{2-[4-(3,4-difluorophenoxy)piperidin-1-...)
Show SMILES Cc1ncsc1C(CNC(=O)c1c(F)cccc1Cl)N1CCC(CC1)Oc1ccc(F)c(F)c1
Show InChI InChI=1S/C24H23ClF3N3O2S/c1-14-23(34-13-30-14)21(12-29-24(32)22-17(25)3-2-4-19(22)27)31-9-7-15(8-10-31)33-16-5-6-18(26)20(28)11-16/h2-6,11,13,15,21H,7-10,12H2,1H3,(H,29,32)
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n/an/a 25.8n/an/an/an/an/an/a



Axxam S.P.A.

US Patent


Assay Description
In order to directly monitor the block of P2X7 channel, an electrophysiological assay was developed and implemented on the QPatch16X automated electr...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM446080
PNG
(N-{2-[4-(3-fluorophenoxy)piperidin-1-yl]-2-(4-meth...)
Show SMILES Cc1ncsc1C(CNC(=O)c1cccc2ncccc12)N1CCC(CC1)Oc1cccc(F)c1
Show InChI InChI=1S/C27H27FN4O2S/c1-18-26(35-17-31-18)25(16-30-27(33)23-7-3-9-24-22(23)8-4-12-29-24)32-13-10-20(11-14-32)34-21-6-2-5-19(28)15-21/h2-9,12,15,17,20,25H,10-11,13-14,16H2,1H3,(H,30,33)
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n/an/a 26.4n/an/an/an/an/an/a



Axxam S.P.A.

US Patent


Assay Description
In order to directly monitor the block of P2X7 channel, an electrophysiological assay was developed and implemented on the QPatch16X automated electr...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM446068
PNG
(2-chloro-6-fluoro-N-(2-{4-[(2-fluorophenyl)methoxy...)
Show SMILES Cc1ncsc1C(CNC(=O)c1c(F)cccc1Cl)N1CCC(CC1)OCc1ccccc1F
Show InChI InChI=1S/C25H26ClF2N3O2S/c1-16-24(34-15-30-16)22(13-29-25(32)23-19(26)6-4-8-21(23)28)31-11-9-18(10-12-31)33-14-17-5-2-3-7-20(17)27/h2-8,15,18,22H,9-14H2,1H3,(H,29,32)
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n/an/a 28.1n/an/an/an/an/an/a



Axxam S.P.A.

US Patent


Assay Description
In order to directly monitor the block of P2X7 channel, an electrophysiological assay was developed and implemented on the QPatch16X automated electr...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM446083
PNG
(2-chloro-N-{2-[4-(difluoromethyl)-1,3-thiazol-5-yl...)
Show SMILES FC(F)c1ncsc1C(CNC(=O)c1c(F)cccc1Cl)N1CCC(CC1)Oc1cccc(F)c1
Show InChI InChI=1S/C24H22ClF4N3O2S/c25-17-5-2-6-18(27)20(17)24(33)30-12-19(22-21(23(28)29)31-13-35-22)32-9-7-15(8-10-32)34-16-4-1-3-14(26)11-16/h1-6,11,13,15,19,23H,7-10,12H2,(H,30,33)
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n/an/a 28.9n/an/an/an/an/an/a



Axxam S.P.A.

US Patent


Assay Description
In order to directly monitor the block of P2X7 channel, an electrophysiological assay was developed and implemented on the QPatch16X automated electr...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM446081
PNG
(N-{2-[4-(2-fluorophenoxy)piperidin-1-yl]-2-(4-meth...)
Show SMILES Cc1ncsc1C(CNC(=O)c1cccc2ncccc12)N1CCC(CC1)Oc1ccccc1F
Show InChI InChI=1S/C27H27FN4O2S/c1-18-26(35-17-31-18)24(16-30-27(33)21-6-4-9-23-20(21)7-5-13-29-23)32-14-11-19(12-15-32)34-25-10-3-2-8-22(25)28/h2-10,13,17,19,24H,11-12,14-16H2,1H3,(H,30,33)
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n/an/a 30.2n/an/an/an/an/an/a



Axxam S.P.A.

US Patent


Assay Description
In order to directly monitor the block of P2X7 channel, an electrophysiological assay was developed and implemented on the QPatch16X automated electr...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM446073
PNG
(2-chloro-N-{2-[4-(3,5-difluorophenoxy)piperidin-1-...)
Show SMILES Cc1ncsc1C(CNC(=O)c1c(F)cccc1Cl)N1CCC(CC1)Oc1cc(F)cc(F)c1
Show InChI InChI=1S/C24H23ClF3N3O2S/c1-14-23(34-13-30-14)21(12-29-24(32)22-19(25)3-2-4-20(22)28)31-7-5-17(6-8-31)33-18-10-15(26)9-16(27)11-18/h2-4,9-11,13,17,21H,5-8,12H2,1H3,(H,29,32)
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n/an/a 30.6n/an/an/an/an/an/a



Axxam S.P.A.

US Patent


Assay Description
In order to directly monitor the block of P2X7 channel, an electrophysiological assay was developed and implemented on the QPatch16X automated electr...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM446077
PNG
(N-(2-{4-[(3,5-difluorophenyl)methoxy]piperidin-1-y...)
Show SMILES Cc1ncsc1C(CNC(=O)c1cccc2ncccc12)N1CCC(CC1)OCc1cc(F)cc(F)c1
Show InChI InChI=1S/C28H28F2N4O2S/c1-18-27(37-17-33-18)26(15-32-28(35)24-4-2-6-25-23(24)5-3-9-31-25)34-10-7-22(8-11-34)36-16-19-12-20(29)14-21(30)13-19/h2-6,9,12-14,17,22,26H,7-8,10-11,15-16H2,1H3,(H,32,35)
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n/an/a 32.9n/an/an/an/an/an/a



Axxam S.P.A.

US Patent


Assay Description
In order to directly monitor the block of P2X7 channel, an electrophysiological assay was developed and implemented on the QPatch16X automated electr...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM446069
PNG
(2-chloro-N-(2-{4-[(3,5-difluorophenyl)methoxy]pipe...)
Show SMILES Cc1ncsc1C(CNC(=O)c1c(F)cccc1Cl)N1CCC(CC1)OCc1cc(F)cc(F)c1
Show InChI InChI=1S/C25H25ClF3N3O2S/c1-15-24(35-14-31-15)22(12-30-25(33)23-20(26)3-2-4-21(23)29)32-7-5-19(6-8-32)34-13-16-9-17(27)11-18(28)10-16/h2-4,9-11,14,19,22H,5-8,12-13H2,1H3,(H,30,33)
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n/an/a 35.1n/an/an/an/an/an/a



Axxam S.P.A.

US Patent


Assay Description
In order to directly monitor the block of P2X7 channel, an electrophysiological assay was developed and implemented on the QPatch16X automated electr...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM446078
PNG
(N-(2-{4-[(3,4-difluorophenyl)methoxy]piperidin-1-y...)
Show SMILES Cc1ncsc1C(CNC(=O)c1cccc2ncccc12)N1CCC(CC1)OCc1ccc(F)c(F)c1
Show InChI InChI=1S/C28H28F2N4O2S/c1-18-27(37-17-33-18)26(15-32-28(35)22-4-2-6-25-21(22)5-3-11-31-25)34-12-9-20(10-13-34)36-16-19-7-8-23(29)24(30)14-19/h2-8,11,14,17,20,26H,9-10,12-13,15-16H2,1H3,(H,32,35)
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n/an/a 36.9n/an/an/an/an/an/a



Axxam S.P.A.

US Patent


Assay Description
In order to directly monitor the block of P2X7 channel, an electrophysiological assay was developed and implemented on the QPatch16X automated electr...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM446086
PNG
(N-{2-[4-(difluoromethyl)-1,3-thiazol-5-yl]-2-[4-(4...)
Show SMILES FC(F)c1ncsc1C(CNC(=O)c1cccc2ncccc12)N1CCC(CC1)Oc1ccc(F)cc1
Show InChI InChI=1S/C27H25F3N4O2S/c28-17-6-8-18(9-7-17)36-19-10-13-34(14-11-19)23(25-24(26(29)30)33-16-37-25)15-32-27(35)21-3-1-5-22-20(21)4-2-12-31-22/h1-9,12,16,19,23,26H,10-11,13-15H2,(H,32,35)
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n/an/a 39.7n/an/an/an/an/an/a



Axxam S.P.A.

US Patent


Assay Description
In order to directly monitor the block of P2X7 channel, an electrophysiological assay was developed and implemented on the QPatch16X automated electr...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM446084
PNG
(2-chloro-N-{2-[4-(difluoromethyl)-1,3-thiazol-5-yl...)
Show SMILES FC(F)c1ncsc1C(CNC(=O)c1c(F)cccc1Cl)N1CCC(CC1)Oc1ccccc1F
Show InChI InChI=1S/C24H22ClF4N3O2S/c25-15-4-3-6-17(27)20(15)24(33)30-12-18(22-21(23(28)29)31-13-35-22)32-10-8-14(9-11-32)34-19-7-2-1-5-16(19)26/h1-7,13-14,18,23H,8-12H2,(H,30,33)
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n/an/a 40.7n/an/an/an/an/an/a



Axxam S.P.A.

US Patent


Assay Description
In order to directly monitor the block of P2X7 channel, an electrophysiological assay was developed and implemented on the QPatch16X automated electr...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM446075
PNG
(N-(2-{4-[(4-fluorophenyl)methoxy]piperidin-1-yl}-2...)
Show SMILES Cc1ncsc1C(CNC(=O)c1cccc2ncccc12)N1CCC(CC1)OCc1ccc(F)cc1
Show InChI InChI=1S/C28H29FN4O2S/c1-19-27(36-18-32-19)26(16-31-28(34)24-4-2-6-25-23(24)5-3-13-30-25)33-14-11-22(12-15-33)35-17-20-7-9-21(29)10-8-20/h2-10,13,18,22,26H,11-12,14-17H2,1H3,(H,31,34)
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n/an/a 42.1n/an/an/an/an/an/a



Axxam S.P.A.

US Patent


Assay Description
In order to directly monitor the block of P2X7 channel, an electrophysiological assay was developed and implemented on the QPatch16X automated electr...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM446072
PNG
(2-chloro-6-fluoro-N-{2-[4-(2-fluorophenoxy)piperid...)
Show SMILES Cc1ncsc1C(CNC(=O)c1c(F)cccc1Cl)N1CCC(CC1)Oc1ccccc1F
Show InChI InChI=1S/C24H24ClF2N3O2S/c1-15-23(33-14-29-15)20(13-28-24(31)22-17(25)5-4-7-19(22)27)30-11-9-16(10-12-30)32-21-8-3-2-6-18(21)26/h2-8,14,16,20H,9-13H2,1H3,(H,28,31)
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n/an/a 42.9n/an/an/an/an/an/a



Axxam S.P.A.

US Patent


Assay Description
In order to directly monitor the block of P2X7 channel, an electrophysiological assay was developed and implemented on the QPatch16X automated electr...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM446087
PNG
(N-{2-[4-(difluoromethyl)-1,3-thiazol-5-yl]-2-[4-(2...)
Show SMILES FC(F)c1ncsc1C(CNC(=O)c1cccc2ncccc12)N1CCC(CC1)Oc1ccccc1F
Show InChI InChI=1S/C27H25F3N4O2S/c28-20-7-1-2-9-23(20)36-17-10-13-34(14-11-17)22(25-24(26(29)30)33-16-37-25)15-32-27(35)19-5-3-8-21-18(19)6-4-12-31-21/h1-9,12,16-17,22,26H,10-11,13-15H2,(H,32,35)
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n/an/a 43.2n/an/an/an/an/an/a



Axxam S.P.A.

US Patent


Assay Description
In order to directly monitor the block of P2X7 channel, an electrophysiological assay was developed and implemented on the QPatch16X automated electr...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM446066
PNG
(2-chloro-6-fluoro-N-(2-{4-[(4-fluorophenyl)methoxy...)
Show SMILES Cc1ncsc1C(CNC(=O)c1c(F)cccc1Cl)N1CCC(CC1)OCc1ccc(F)cc1
Show InChI InChI=1S/C25H26ClF2N3O2S/c1-16-24(34-15-30-16)22(13-29-25(32)23-20(26)3-2-4-21(23)28)31-11-9-19(10-12-31)33-14-17-5-7-18(27)8-6-17/h2-8,15,19,22H,9-14H2,1H3,(H,29,32)
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n/an/a 45n/an/an/an/an/an/a



Axxam S.P.A.

US Patent


Assay Description
In order to directly monitor the block of P2X7 channel, an electrophysiological assay was developed and implemented on the QPatch16X automated electr...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM446070
PNG
(2-chloro-6-fluoro-N-{2-[4-(4-fluorophenoxy)piperid...)
Show SMILES Cc1ncsc1C(CNC(=O)c1c(F)cccc1Cl)N1CCC(CC1)Oc1ccc(F)cc1
Show InChI InChI=1S/C24H24ClF2N3O2S/c1-15-23(33-14-29-15)21(13-28-24(31)22-19(25)3-2-4-20(22)27)30-11-9-18(10-12-30)32-17-7-5-16(26)6-8-17/h2-8,14,18,21H,9-13H2,1H3,(H,28,31)
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Axxam S.P.A.

US Patent


Assay Description
In order to directly monitor the block of P2X7 channel, an electrophysiological assay was developed and implemented on the QPatch16X automated electr...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM446085
PNG
(N-{2-[4-(difluoromethyl)-1,3-thiazol-5-yl]-2-{44(3...)
Show SMILES FC(F)c1ncsc1C(CNC(=O)c1cccc2ncccc12)N1CCC(CC1)OCc1ccc(F)c(F)c1
Show InChI InChI=1S/C28H26F4N4O2S/c29-21-7-6-17(13-22(21)30)15-38-18-8-11-36(12-9-18)24(26-25(27(31)32)35-16-39-26)14-34-28(37)20-3-1-5-23-19(20)4-2-10-33-23/h1-7,10,13,16,18,24,27H,8-9,11-12,14-15H2,(H,34,37)
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Axxam S.P.A.

US Patent


Assay Description
In order to directly monitor the block of P2X7 channel, an electrophysiological assay was developed and implemented on the QPatch16X automated electr...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM446082
PNG
(N-{2-[4-(3,4-difluorophenoxy)piperidin-1-yl]-2-(4-...)
Show SMILES Cc1ncsc1C(CNC(=O)c1cccc2ncccc12)N1CCC(CC1)Oc1ccc(F)c(F)c1
Show InChI InChI=1S/C27H26F2N4O2S/c1-17-26(36-16-32-17)25(15-31-27(34)21-4-2-6-24-20(21)5-3-11-30-24)33-12-9-18(10-13-33)35-19-7-8-22(28)23(29)14-19/h2-8,11,14,16,18,25H,9-10,12-13,15H2,1H3,(H,31,34)
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Axxam S.P.A.

US Patent


Assay Description
In order to directly monitor the block of P2X7 channel, an electrophysiological assay was developed and implemented on the QPatch16X automated electr...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Rattus norvegicus (Rat))
BDBM446087
PNG
(N-{2-[4-(difluoromethyl)-1,3-thiazol-5-yl]-2-[4-(2...)
Show SMILES FC(F)c1ncsc1C(CNC(=O)c1cccc2ncccc12)N1CCC(CC1)Oc1ccccc1F
Show InChI InChI=1S/C27H25F3N4O2S/c28-20-7-1-2-9-23(20)36-17-10-13-34(14-11-17)22(25-24(26(29)30)33-16-37-25)15-32-27(35)19-5-3-8-21-18(19)6-4-12-31-21/h1-9,12,16-17,22,26H,10-11,13-15H2,(H,32,35)
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Axxam S.P.A.

US Patent


Assay Description
Ca2+ influx was measured in HEK-293 cells stably transfected with the receptor using Screen Quest™ Fluo-8 No Wash Calcium Assay Kit (AAt Bioquest®). ...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Rattus norvegicus (Rat))
BDBM446087
PNG
(N-{2-[4-(difluoromethyl)-1,3-thiazol-5-yl]-2-[4-(2...)
Show SMILES FC(F)c1ncsc1C(CNC(=O)c1cccc2ncccc12)N1CCC(CC1)Oc1ccccc1F
Show InChI InChI=1S/C27H25F3N4O2S/c28-20-7-1-2-9-23(20)36-17-10-13-34(14-11-17)22(25-24(26(29)30)33-16-37-25)15-32-27(35)19-5-3-8-21-18(19)6-4-12-31-21/h1-9,12,16-17,22,26H,10-11,13-15H2,(H,32,35)
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Axxam S.P.A.

US Patent


Assay Description
Ca2+ influx was measured in HEK-293 cells stably transfected with the receptor using Screen Quest™ Fluo-8 No Wash Calcium Assay Kit (AAt Bioquest®). ...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Rattus norvegicus (Rat))
BDBM446086
PNG
(N-{2-[4-(difluoromethyl)-1,3-thiazol-5-yl]-2-[4-(4...)
Show SMILES FC(F)c1ncsc1C(CNC(=O)c1cccc2ncccc12)N1CCC(CC1)Oc1ccc(F)cc1
Show InChI InChI=1S/C27H25F3N4O2S/c28-17-6-8-18(9-7-17)36-19-10-13-34(14-11-19)23(25-24(26(29)30)33-16-37-25)15-32-27(35)21-3-1-5-22-20(21)4-2-12-31-22/h1-9,12,16,19,23,26H,10-11,13-15H2,(H,32,35)
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Axxam S.P.A.

US Patent


Assay Description
Ca2+ influx was measured in HEK-293 cells stably transfected with the receptor using Screen Quest™ Fluo-8 No Wash Calcium Assay Kit (AAt Bioquest®). ...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Rattus norvegicus (Rat))
BDBM446086
PNG
(N-{2-[4-(difluoromethyl)-1,3-thiazol-5-yl]-2-[4-(4...)
Show SMILES FC(F)c1ncsc1C(CNC(=O)c1cccc2ncccc12)N1CCC(CC1)Oc1ccc(F)cc1
Show InChI InChI=1S/C27H25F3N4O2S/c28-17-6-8-18(9-7-17)36-19-10-13-34(14-11-19)23(25-24(26(29)30)33-16-37-25)15-32-27(35)21-3-1-5-22-20(21)4-2-12-31-22/h1-9,12,16,19,23,26H,10-11,13-15H2,(H,32,35)
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Axxam S.P.A.

US Patent


Assay Description
Ca2+ influx was measured in HEK-293 cells stably transfected with the receptor using Screen Quest™ Fluo-8 No Wash Calcium Assay Kit (AAt Bioquest®). ...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Rattus norvegicus (Rat))
BDBM446085
PNG
(N-{2-[4-(difluoromethyl)-1,3-thiazol-5-yl]-2-{44(3...)
Show SMILES FC(F)c1ncsc1C(CNC(=O)c1cccc2ncccc12)N1CCC(CC1)OCc1ccc(F)c(F)c1
Show InChI InChI=1S/C28H26F4N4O2S/c29-21-7-6-17(13-22(21)30)15-38-18-8-11-36(12-9-18)24(26-25(27(31)32)35-16-39-26)14-34-28(37)20-3-1-5-23-19(20)4-2-10-33-23/h1-7,10,13,16,18,24,27H,8-9,11-12,14-15H2,(H,34,37)
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Axxam S.P.A.

US Patent


Assay Description
Ca2+ influx was measured in HEK-293 cells stably transfected with the receptor using Screen Quest™ Fluo-8 No Wash Calcium Assay Kit (AAt Bioquest®). ...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Rattus norvegicus (Rat))
BDBM446082
PNG
(N-{2-[4-(3,4-difluorophenoxy)piperidin-1-yl]-2-(4-...)
Show SMILES Cc1ncsc1C(CNC(=O)c1cccc2ncccc12)N1CCC(CC1)Oc1ccc(F)c(F)c1
Show InChI InChI=1S/C27H26F2N4O2S/c1-17-26(36-16-32-17)25(15-31-27(34)21-4-2-6-24-20(21)5-3-11-30-24)33-12-9-18(10-13-33)35-19-7-8-22(28)23(29)14-19/h2-8,11,14,16,18,25H,9-10,12-13,15H2,1H3,(H,31,34)
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Axxam S.P.A.

US Patent


Assay Description
Ca2+ influx was measured in HEK-293 cells stably transfected with the receptor using Screen Quest™ Fluo-8 No Wash Calcium Assay Kit (AAt Bioquest®). ...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Rattus norvegicus (Rat))
BDBM446082
PNG
(N-{2-[4-(3,4-difluorophenoxy)piperidin-1-yl]-2-(4-...)
Show SMILES Cc1ncsc1C(CNC(=O)c1cccc2ncccc12)N1CCC(CC1)Oc1ccc(F)c(F)c1
Show InChI InChI=1S/C27H26F2N4O2S/c1-17-26(36-16-32-17)25(15-31-27(34)21-4-2-6-24-20(21)5-3-11-30-24)33-12-9-18(10-13-33)35-19-7-8-22(28)23(29)14-19/h2-8,11,14,16,18,25H,9-10,12-13,15H2,1H3,(H,31,34)
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Axxam S.P.A.

US Patent


Assay Description
Ca2+ influx was measured in HEK-293 cells stably transfected with the receptor using Screen Quest™ Fluo-8 No Wash Calcium Assay Kit (AAt Bioquest®). ...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Rattus norvegicus (Rat))
BDBM446103
PNG
(N-{2-[4-(difluoromethyl)-1,3-thiazol-5-yl]-2-[4-(3...)
Show SMILES FC(F)c1ncsc1C(CNC(=O)c1cccc2ncccc12)N1CCC(CC1)Oc1cc(F)cc(F)c1
Show InChI InChI=1S/C27H24F4N4O2S/c28-16-11-17(29)13-19(12-16)37-18-6-9-35(10-7-18)23(25-24(26(30)31)34-15-38-25)14-33-27(36)21-3-1-5-22-20(21)4-2-8-32-22/h1-5,8,11-13,15,18,23,26H,6-7,9-10,14H2,(H,33,36)
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Axxam S.P.A.

US Patent


Assay Description
Ca2+ influx was measured in HEK-293 cells stably transfected with the receptor using Screen Quest™ Fluo-8 No Wash Calcium Assay Kit (AAt Bioquest®). ...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Rattus norvegicus (Rat))
BDBM446100
PNG
(N-{2-[4-(difluoromethyl)-1,3-thiazol-5-yl]-2-{4-[(...)
Show SMILES FC(F)c1ncsc1C(CNC(=O)c1cccc2ncccc12)N1CCC(CC1)OCc1ccccc1F
Show InChI InChI=1S/C28H27F3N4O2S/c29-22-8-2-1-5-18(22)16-37-19-10-13-35(14-11-19)24(26-25(27(30)31)34-17-38-26)15-33-28(36)21-6-3-9-23-20(21)7-4-12-32-23/h1-9,12,17,19,24,27H,10-11,13-16H2,(H,33,36)
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Axxam S.P.A.

US Patent


Assay Description
Ca2+ influx was measured in HEK-293 cells stably transfected with the receptor using Screen Quest™ Fluo-8 No Wash Calcium Assay Kit (AAt Bioquest®). ...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Rattus norvegicus (Rat))
BDBM446095
PNG
(2-chloro-N-{2-[4-(difluoromethyl)-1,3-thiazol-5-yl...)
Show SMILES FC(F)c1ncsc1C(CNC(=O)c1c(F)cccc1Cl)N1CCC(CC1)OCc1ccccc1F
Show InChI InChI=1S/C25H24ClF4N3O2S/c26-17-5-3-7-19(28)21(17)25(34)31-12-20(23-22(24(29)30)32-14-36-23)33-10-8-16(9-11-33)35-13-15-4-1-2-6-18(15)27/h1-7,14,16,20,24H,8-13H2,(H,31,34)
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Axxam S.P.A.

US Patent


Assay Description
Ca2+ influx was measured in HEK-293 cells stably transfected with the receptor using Screen Quest™ Fluo-8 No Wash Calcium Assay Kit (AAt Bioquest®). ...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Rattus norvegicus (Rat))
BDBM446080
PNG
(N-{2-[4-(3-fluorophenoxy)piperidin-1-yl]-2-(4-meth...)
Show SMILES Cc1ncsc1C(CNC(=O)c1cccc2ncccc12)N1CCC(CC1)Oc1cccc(F)c1
Show InChI InChI=1S/C27H27FN4O2S/c1-18-26(35-17-31-18)25(16-30-27(33)23-7-3-9-24-22(23)8-4-12-29-24)32-13-10-20(11-14-32)34-21-6-2-5-19(28)15-21/h2-9,12,15,17,20,25H,10-11,13-14,16H2,1H3,(H,30,33)
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Axxam S.P.A.

US Patent


Assay Description
Ca2+ influx was measured in HEK-293 cells stably transfected with the receptor using Screen Quest™ Fluo-8 No Wash Calcium Assay Kit (AAt Bioquest®). ...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Rattus norvegicus (Rat))
BDBM446080
PNG
(N-{2-[4-(3-fluorophenoxy)piperidin-1-yl]-2-(4-meth...)
Show SMILES Cc1ncsc1C(CNC(=O)c1cccc2ncccc12)N1CCC(CC1)Oc1cccc(F)c1
Show InChI InChI=1S/C27H27FN4O2S/c1-18-26(35-17-31-18)25(16-30-27(33)23-7-3-9-24-22(23)8-4-12-29-24)32-13-10-20(11-14-32)34-21-6-2-5-19(28)15-21/h2-9,12,15,17,20,25H,10-11,13-14,16H2,1H3,(H,30,33)
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Axxam S.P.A.

US Patent


Assay Description
Ca2+ influx was measured in HEK-293 cells stably transfected with the receptor using Screen Quest™ Fluo-8 No Wash Calcium Assay Kit (AAt Bioquest®). ...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Rattus norvegicus (Rat))
BDBM446076
PNG
(N-(2-{4-[(3-fluorophenyl)methoxy]piperidin-1-yl}-2...)
Show SMILES Cc1ncsc1C(CNC(=O)c1cccc2ncccc12)N1CCC(CC1)OCc1cccc(F)c1
Show InChI InChI=1S/C28H29FN4O2S/c1-19-27(36-18-32-19)26(16-31-28(34)24-7-3-9-25-23(24)8-4-12-30-25)33-13-10-22(11-14-33)35-17-20-5-2-6-21(29)15-20/h2-9,12,15,18,22,26H,10-11,13-14,16-17H2,1H3,(H,31,34)
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Axxam S.P.A.

US Patent


Assay Description
Ca2+ influx was measured in HEK-293 cells stably transfected with the receptor using Screen Quest™ Fluo-8 No Wash Calcium Assay Kit (AAt Bioquest®). ...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Rattus norvegicus (Rat))
BDBM446102
PNG
(N-{2-[4-(difluoromethyl)-1,3-thiazol-5-yl]-2-[4-(3...)
Show SMILES FC(F)c1ncsc1C(CNC(=O)c1cccc2ncccc12)N1CCC(CC1)Oc1cccc(F)c1
Show InChI InChI=1S/C27H25F3N4O2S/c28-17-4-1-5-19(14-17)36-18-9-12-34(13-10-18)23(25-24(26(29)30)33-16-37-25)15-32-27(35)21-6-2-8-22-20(21)7-3-11-31-22/h1-8,11,14,16,18,23,26H,9-10,12-13,15H2,(H,32,35)
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Axxam S.P.A.

US Patent


Assay Description
Ca2+ influx was measured in HEK-293 cells stably transfected with the receptor using Screen Quest™ Fluo-8 No Wash Calcium Assay Kit (AAt Bioquest®). ...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Rattus norvegicus (Rat))
BDBM446101
PNG
(N-{2-[4-(4-chlorophenoxy)piperidin-1-yl]-2-[4-(dif...)
Show SMILES FC(F)c1ncsc1C(CNC(=O)c1cccc2ncccc12)N1CCC(CC1)Oc1ccc(Cl)cc1
Show InChI InChI=1S/C27H25ClF2N4O2S/c28-17-6-8-18(9-7-17)36-19-10-13-34(14-11-19)23(25-24(26(29)30)33-16-37-25)15-32-27(35)21-3-1-5-22-20(21)4-2-12-31-22/h1-9,12,16,19,23,26H,10-11,13-15H2,(H,32,35)
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Axxam S.P.A.

US Patent


Assay Description
Ca2+ influx was measured in HEK-293 cells stably transfected with the receptor using Screen Quest™ Fluo-8 No Wash Calcium Assay Kit (AAt Bioquest®). ...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Rattus norvegicus (Rat))
BDBM446084
PNG
(2-chloro-N-{2-[4-(difluoromethyl)-1,3-thiazol-5-yl...)
Show SMILES FC(F)c1ncsc1C(CNC(=O)c1c(F)cccc1Cl)N1CCC(CC1)Oc1ccccc1F
Show InChI InChI=1S/C24H22ClF4N3O2S/c25-15-4-3-6-17(27)20(15)24(33)30-12-18(22-21(23(28)29)31-13-35-22)32-10-8-14(9-11-32)34-19-7-2-1-5-16(19)26/h1-7,13-14,18,23H,8-12H2,(H,30,33)
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Axxam S.P.A.

US Patent


Assay Description
Ca2+ influx was measured in HEK-293 cells stably transfected with the receptor using Screen Quest™ Fluo-8 No Wash Calcium Assay Kit (AAt Bioquest®). ...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Rattus norvegicus (Rat))
BDBM446081
PNG
(N-{2-[4-(2-fluorophenoxy)piperidin-1-yl]-2-(4-meth...)
Show SMILES Cc1ncsc1C(CNC(=O)c1cccc2ncccc12)N1CCC(CC1)Oc1ccccc1F
Show InChI InChI=1S/C27H27FN4O2S/c1-18-26(35-17-31-18)24(16-30-27(33)21-6-4-9-23-20(21)7-5-13-29-23)32-14-11-19(12-15-32)34-25-10-3-2-8-22(25)28/h2-10,13,17,19,24H,11-12,14-16H2,1H3,(H,30,33)
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Axxam S.P.A.

US Patent


Assay Description
Ca2+ influx was measured in HEK-293 cells stably transfected with the receptor using Screen Quest™ Fluo-8 No Wash Calcium Assay Kit (AAt Bioquest®). ...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Rattus norvegicus (Rat))
BDBM446075
PNG
(N-(2-{4-[(4-fluorophenyl)methoxy]piperidin-1-yl}-2...)
Show SMILES Cc1ncsc1C(CNC(=O)c1cccc2ncccc12)N1CCC(CC1)OCc1ccc(F)cc1
Show InChI InChI=1S/C28H29FN4O2S/c1-19-27(36-18-32-19)26(16-31-28(34)24-4-2-6-25-23(24)5-3-13-30-25)33-14-11-22(12-15-33)35-17-20-7-9-21(29)10-8-20/h2-10,13,18,22,26H,11-12,14-17H2,1H3,(H,31,34)
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Axxam S.P.A.

US Patent


Assay Description
Ca2+ influx was measured in HEK-293 cells stably transfected with the receptor using Screen Quest™ Fluo-8 No Wash Calcium Assay Kit (AAt Bioquest®). ...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Rattus norvegicus (Rat))
BDBM446067
PNG
(2-chloro-6-fluoro-N-(2-{4-[(3-fluorophenyl)methoxy...)
Show SMILES Cc1ncsc1C(CNC(=O)c1c(F)cccc1Cl)N1CCC(CC1)OCc1cccc(F)c1
Show InChI InChI=1S/C25H26ClF2N3O2S/c1-16-24(34-15-30-16)22(13-29-25(32)23-20(26)6-3-7-21(23)28)31-10-8-19(9-11-31)33-14-17-4-2-5-18(27)12-17/h2-7,12,15,19,22H,8-11,13-14H2,1H3,(H,29,32)
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n/an/a 373n/an/an/an/an/an/a



Axxam S.P.A.

US Patent


Assay Description
Ca2+ influx was measured in HEK-293 cells stably transfected with the receptor using Screen Quest™ Fluo-8 No Wash Calcium Assay Kit (AAt Bioquest®). ...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Rattus norvegicus (Rat))
BDBM446078
PNG
(N-(2-{4-[(3,4-difluorophenyl)methoxy]piperidin-1-y...)
Show SMILES Cc1ncsc1C(CNC(=O)c1cccc2ncccc12)N1CCC(CC1)OCc1ccc(F)c(F)c1
Show InChI InChI=1S/C28H28F2N4O2S/c1-18-27(37-17-33-18)26(15-32-28(35)22-4-2-6-25-21(22)5-3-11-31-25)34-12-9-20(10-13-34)36-16-19-7-8-23(29)24(30)14-19/h2-8,11,14,17,20,26H,9-10,12-13,15-16H2,1H3,(H,32,35)
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n/an/a 374n/an/an/an/an/an/a



Axxam S.P.A.

US Patent


Assay Description
Ca2+ influx was measured in HEK-293 cells stably transfected with the receptor using Screen Quest™ Fluo-8 No Wash Calcium Assay Kit (AAt Bioquest®). ...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Rattus norvegicus (Rat))
BDBM446074
PNG
(2-chloro-N-{2-[4-(3,4-difluorophenoxy)piperidin-1-...)
Show SMILES Cc1ncsc1C(CNC(=O)c1c(F)cccc1Cl)N1CCC(CC1)Oc1ccc(F)c(F)c1
Show InChI InChI=1S/C24H23ClF3N3O2S/c1-14-23(34-13-30-14)21(12-29-24(32)22-17(25)3-2-4-19(22)27)31-9-7-15(8-10-31)33-16-5-6-18(26)20(28)11-16/h2-6,11,13,15,21H,7-10,12H2,1H3,(H,29,32)
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n/an/a 380n/an/an/an/an/an/a



Axxam S.P.A.

US Patent


Assay Description
Ca2+ influx was measured in HEK-293 cells stably transfected with the receptor using Screen Quest™ Fluo-8 No Wash Calcium Assay Kit (AAt Bioquest®). ...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Rattus norvegicus (Rat))
BDBM446071
PNG
(2-chloro-6-fluoro-N-{2-[4-(3-fluorophenoxy)piperid...)
Show SMILES Cc1ncsc1C(CNC(=O)c1c(F)cccc1Cl)N1CCC(CC1)Oc1cccc(F)c1
Show InChI InChI=1S/C24H24ClF2N3O2S/c1-15-23(33-14-29-15)21(13-28-24(31)22-19(25)6-3-7-20(22)27)30-10-8-17(9-11-30)32-18-5-2-4-16(26)12-18/h2-7,12,14,17,21H,8-11,13H2,1H3,(H,28,31)
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n/an/a 402n/an/an/an/an/an/a



Axxam S.P.A.

US Patent


Assay Description
Ca2+ influx was measured in HEK-293 cells stably transfected with the receptor using Screen Quest™ Fluo-8 No Wash Calcium Assay Kit (AAt Bioquest®). ...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Rattus norvegicus (Rat))
BDBM446077
PNG
(N-(2-{4-[(3,5-difluorophenyl)methoxy]piperidin-1-y...)
Show SMILES Cc1ncsc1C(CNC(=O)c1cccc2ncccc12)N1CCC(CC1)OCc1cc(F)cc(F)c1
Show InChI InChI=1S/C28H28F2N4O2S/c1-18-27(37-17-33-18)26(15-32-28(35)24-4-2-6-25-23(24)5-3-9-31-25)34-10-7-22(8-11-34)36-16-19-12-20(29)14-21(30)13-19/h2-6,9,12-14,17,22,26H,7-8,10-11,15-16H2,1H3,(H,32,35)
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n/an/a 432n/an/an/an/an/an/a



Axxam S.P.A.

US Patent


Assay Description
Ca2+ influx was measured in HEK-293 cells stably transfected with the receptor using Screen Quest™ Fluo-8 No Wash Calcium Assay Kit (AAt Bioquest®). ...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Rattus norvegicus (Rat))
BDBM446083
PNG
(2-chloro-N-{2-[4-(difluoromethyl)-1,3-thiazol-5-yl...)
Show SMILES FC(F)c1ncsc1C(CNC(=O)c1c(F)cccc1Cl)N1CCC(CC1)Oc1cccc(F)c1
Show InChI InChI=1S/C24H22ClF4N3O2S/c25-17-5-2-6-18(27)20(17)24(33)30-12-19(22-21(23(28)29)31-13-35-22)32-9-7-15(8-10-32)34-16-4-1-3-14(26)11-16/h1-6,11,13,15,19,23H,7-10,12H2,(H,30,33)
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n/an/a 441n/an/an/an/an/an/a



Axxam S.P.A.

US Patent


Assay Description
Ca2+ influx was measured in HEK-293 cells stably transfected with the receptor using Screen Quest™ Fluo-8 No Wash Calcium Assay Kit (AAt Bioquest®). ...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Rattus norvegicus (Rat))
BDBM446099
PNG
(2-chloro-N-{2-[4-(difluoromethyl)-1,3-thiazol-5-yl...)
Show SMILES FC(F)c1ncsc1C(CNC(=O)c1c(F)cccc1Cl)N1CCC(CC1)Oc1cc(F)cc(F)c1
Show InChI InChI=1S/C24H21ClF5N3O2S/c25-17-2-1-3-18(28)20(17)24(34)31-11-19(22-21(23(29)30)32-12-36-22)33-6-4-15(5-7-33)35-16-9-13(26)8-14(27)10-16/h1-3,8-10,12,15,19,23H,4-7,11H2,(H,31,34)
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n/an/a 458n/an/an/an/an/an/a



Axxam S.P.A.

US Patent


Assay Description
Ca2+ influx was measured in HEK-293 cells stably transfected with the receptor using Screen Quest™ Fluo-8 No Wash Calcium Assay Kit (AAt Bioquest®). ...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Rattus norvegicus (Rat))
BDBM446069
PNG
(2-chloro-N-(2-{4-[(3,5-difluorophenyl)methoxy]pipe...)
Show SMILES Cc1ncsc1C(CNC(=O)c1c(F)cccc1Cl)N1CCC(CC1)OCc1cc(F)cc(F)c1
Show InChI InChI=1S/C25H25ClF3N3O2S/c1-15-24(35-14-31-15)22(12-30-25(33)23-20(26)3-2-4-21(23)29)32-7-5-19(6-8-32)34-13-16-9-17(27)11-18(28)10-16/h2-4,9-11,14,19,22H,5-8,12-13H2,1H3,(H,30,33)
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n/an/a 506n/an/an/an/an/an/a



Axxam S.P.A.

US Patent


Assay Description
Ca2+ influx was measured in HEK-293 cells stably transfected with the receptor using Screen Quest™ Fluo-8 No Wash Calcium Assay Kit (AAt Bioquest®). ...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Rattus norvegicus (Rat))
BDBM446096
PNG
(2-chloro-N-{2[4-(difluoromethyl)-1,3-thiazol-5-yl]...)
Show SMILES FC(F)c1ncsc1C(CNC(=O)c1c(F)cccc1Cl)N1CCC(CC1)OCc1cc(F)cc(F)c1
Show InChI InChI=1S/C25H23ClF5N3O2S/c26-18-2-1-3-19(29)21(18)25(35)32-11-20(23-22(24(30)31)33-13-37-23)34-6-4-17(5-7-34)36-12-14-8-15(27)10-16(28)9-14/h1-3,8-10,13,17,20,24H,4-7,11-12H2,(H,32,35)
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n/an/a 578n/an/an/an/an/an/a



Axxam S.P.A.

US Patent


Assay Description
Ca2+ influx was measured in HEK-293 cells stably transfected with the receptor using Screen Quest™ Fluo-8 No Wash Calcium Assay Kit (AAt Bioquest®). ...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Rattus norvegicus (Rat))
BDBM446079
PNG
(N-{2-[4-(4-fluorophenoxy)piperidin-1-yl]-2-(4-meth...)
Show SMILES Cc1ncsc1C(CNC(=O)c1cccc2ncccc12)N1CCC(CC1)Oc1ccc(F)cc1
Show InChI InChI=1S/C27H27FN4O2S/c1-18-26(35-17-31-18)25(16-30-27(33)23-4-2-6-24-22(23)5-3-13-29-24)32-14-11-21(12-15-32)34-20-9-7-19(28)8-10-20/h2-10,13,17,21,25H,11-12,14-16H2,1H3,(H,30,33)
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n/an/a 582n/an/an/an/an/an/a



Axxam S.P.A.

US Patent


Assay Description
Ca2+ influx was measured in HEK-293 cells stably transfected with the receptor using Screen Quest™ Fluo-8 No Wash Calcium Assay Kit (AAt Bioquest®). ...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Rattus norvegicus (Rat))
BDBM446072
PNG
(2-chloro-6-fluoro-N-{2-[4-(2-fluorophenoxy)piperid...)
Show SMILES Cc1ncsc1C(CNC(=O)c1c(F)cccc1Cl)N1CCC(CC1)Oc1ccccc1F
Show InChI InChI=1S/C24H24ClF2N3O2S/c1-15-23(33-14-29-15)20(13-28-24(31)22-17(25)5-4-7-19(22)27)30-11-9-16(10-12-30)32-21-8-3-2-6-18(21)26/h2-8,14,16,20H,9-13H2,1H3,(H,28,31)
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n/an/a 583n/an/an/an/an/an/a



Axxam S.P.A.

US Patent


Assay Description
Ca2+ influx was measured in HEK-293 cells stably transfected with the receptor using Screen Quest™ Fluo-8 No Wash Calcium Assay Kit (AAt Bioquest®). ...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Rattus norvegicus (Rat))
BDBM446073
PNG
(2-chloro-N-{2-[4-(3,5-difluorophenoxy)piperidin-1-...)
Show SMILES Cc1ncsc1C(CNC(=O)c1c(F)cccc1Cl)N1CCC(CC1)Oc1cc(F)cc(F)c1
Show InChI InChI=1S/C24H23ClF3N3O2S/c1-14-23(34-13-30-14)21(12-29-24(32)22-19(25)3-2-4-20(22)28)31-7-5-17(6-8-31)33-18-10-15(26)9-16(27)11-18/h2-4,9-11,13,17,21H,5-8,12H2,1H3,(H,29,32)
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n/an/a 594n/an/an/an/an/an/a



Axxam S.P.A.

US Patent


Assay Description
Ca2+ influx was measured in HEK-293 cells stably transfected with the receptor using Screen Quest™ Fluo-8 No Wash Calcium Assay Kit (AAt Bioquest®). ...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Rattus norvegicus (Rat))
BDBM446094
PNG
(N-{2-[4-(3,5-difluorophenoxy)piperidin-1-yl]-2-(4-...)
Show SMILES Cc1ncsc1C(CNC(=O)c1cccc2ncccc12)N1CCC(CC1)Oc1cc(F)cc(F)c1
Show InChI InChI=1S/C27H26F2N4O2S/c1-17-26(36-16-32-17)25(15-31-27(34)23-4-2-6-24-22(23)5-3-9-30-24)33-10-7-20(8-11-33)35-21-13-18(28)12-19(29)14-21/h2-6,9,12-14,16,20,25H,7-8,10-11,15H2,1H3,(H,31,34)
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n/an/a 631n/an/an/an/an/an/a



Axxam S.P.A.

US Patent


Assay Description
Ca2+ influx was measured in HEK-293 cells stably transfected with the receptor using Screen Quest™ Fluo-8 No Wash Calcium Assay Kit (AAt Bioquest®). ...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Rattus norvegicus (Rat))
BDBM446070
PNG
(2-chloro-6-fluoro-N-{2-[4-(4-fluorophenoxy)piperid...)
Show SMILES Cc1ncsc1C(CNC(=O)c1c(F)cccc1Cl)N1CCC(CC1)Oc1ccc(F)cc1
Show InChI InChI=1S/C24H24ClF2N3O2S/c1-15-23(33-14-29-15)21(13-28-24(31)22-19(25)3-2-4-20(22)27)30-11-9-18(10-12-30)32-17-7-5-16(26)6-8-17/h2-8,14,18,21H,9-13H2,1H3,(H,28,31)
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n/an/a 709n/an/an/an/an/an/a



Axxam S.P.A.

US Patent


Assay Description
Ca2+ influx was measured in HEK-293 cells stably transfected with the receptor using Screen Quest™ Fluo-8 No Wash Calcium Assay Kit (AAt Bioquest®). ...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Rattus norvegicus (Rat))
BDBM446092
PNG
(N-(2-{4-[(2-fluorophenyl)methoxy]piperidin-1-yl}-2...)
Show SMILES Cc1ncsc1C(CNC(=O)c1cccc2ncccc12)N1CCC(CC1)OCc1ccccc1F
Show InChI InChI=1S/C28H29FN4O2S/c1-19-27(36-18-32-19)26(16-31-28(34)23-7-4-10-25-22(23)8-5-13-30-25)33-14-11-21(12-15-33)35-17-20-6-2-3-9-24(20)29/h2-10,13,18,21,26H,11-12,14-17H2,1H3,(H,31,34)
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n/an/a 762n/an/an/an/an/an/a



Axxam S.P.A.

US Patent


Assay Description
Ca2+ influx was measured in HEK-293 cells stably transfected with the receptor using Screen Quest™ Fluo-8 No Wash Calcium Assay Kit (AAt Bioquest®). ...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Rattus norvegicus (Rat))
BDBM446093
PNG
(N-{2-[4-(4-chlorophenoxy)piperidin-1-yl]-2-(4-meth...)
Show SMILES Cc1ncsc1C(CNC(=O)c1cccc2ncccc12)N1CCC(CC1)Oc1ccc(Cl)cc1
Show InChI InChI=1S/C27H27ClN4O2S/c1-18-26(35-17-31-18)25(16-30-27(33)23-4-2-6-24-22(23)5-3-13-29-24)32-14-11-21(12-15-32)34-20-9-7-19(28)8-10-20/h2-10,13,17,21,25H,11-12,14-16H2,1H3,(H,30,33)
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n/an/a 808n/an/an/an/an/an/a



Axxam S.P.A.

US Patent


Assay Description
Ca2+ influx was measured in HEK-293 cells stably transfected with the receptor using Screen Quest™ Fluo-8 No Wash Calcium Assay Kit (AAt Bioquest®). ...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Rattus norvegicus (Rat))
BDBM446068
PNG
(2-chloro-6-fluoro-N-(2-{4-[(2-fluorophenyl)methoxy...)
Show SMILES Cc1ncsc1C(CNC(=O)c1c(F)cccc1Cl)N1CCC(CC1)OCc1ccccc1F
Show InChI InChI=1S/C25H26ClF2N3O2S/c1-16-24(34-15-30-16)22(13-29-25(32)23-19(26)6-4-8-21(23)28)31-11-9-18(10-12-31)33-14-17-5-2-3-7-20(17)27/h2-8,15,18,22H,9-14H2,1H3,(H,29,32)
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n/an/a 953n/an/an/an/an/an/a



Axxam S.P.A.

US Patent


Assay Description
Ca2+ influx was measured in HEK-293 cells stably transfected with the receptor using Screen Quest™ Fluo-8 No Wash Calcium Assay Kit (AAt Bioquest®). ...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Rattus norvegicus (Rat))
BDBM446088
PNG
(2-chloro-N-(2-{4-[(4-chlorophenyl)methoxy]piperidi...)
Show SMILES Cc1ncsc1C(CNC(=O)c1c(F)cccc1Cl)N1CCC(CC1)OCc1ccc(Cl)cc1
Show InChI InChI=1S/C25H26Cl2FN3O2S/c1-16-24(34-15-30-16)22(13-29-25(32)23-20(27)3-2-4-21(23)28)31-11-9-19(10-12-31)33-14-17-5-7-18(26)8-6-17/h2-8,15,19,22H,9-14H2,1H3,(H,29,32)
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n/an/a 971n/an/an/an/an/an/a



Axxam S.P.A.

US Patent


Assay Description
Ca2+ influx was measured in HEK-293 cells stably transfected with the receptor using Screen Quest™ Fluo-8 No Wash Calcium Assay Kit (AAt Bioquest®). ...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Rattus norvegicus (Rat))
BDBM446104
PNG
(US10669267, Compound 59-of-WO2015118019)
Show SMILES Cc1ncsc1C(CN)N1CCC(CC1)Oc1ccccc1
Show InChI InChI=1S/C17H23N3OS/c1-13-17(22-12-19-13)16(11-18)20-9-7-15(8-10-20)21-14-5-3-2-4-6-14/h2-6,12,15-16H,7-11,18H2,1H3
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n/an/a 1.02E+3n/an/an/an/an/an/a



Axxam S.P.A.

US Patent


Assay Description
Ca2+ influx was measured in HEK-293 cells stably transfected with the receptor using Screen Quest™ Fluo-8 No Wash Calcium Assay Kit (AAt Bioquest®). ...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Rattus norvegicus (Rat))
BDBM446066
PNG
(2-chloro-6-fluoro-N-(2-{4-[(4-fluorophenyl)methoxy...)
Show SMILES Cc1ncsc1C(CNC(=O)c1c(F)cccc1Cl)N1CCC(CC1)OCc1ccc(F)cc1
Show InChI InChI=1S/C25H26ClF2N3O2S/c1-16-24(34-15-30-16)22(13-29-25(32)23-20(26)3-2-4-21(23)28)31-11-9-19(10-12-31)33-14-17-5-7-18(27)8-6-17/h2-8,15,19,22H,9-14H2,1H3,(H,29,32)
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n/an/a 1.04E+3n/an/an/an/an/an/a



Axxam S.P.A.

US Patent


Assay Description
Ca2+ influx was measured in HEK-293 cells stably transfected with the receptor using Screen Quest™ Fluo-8 No Wash Calcium Assay Kit (AAt Bioquest®). ...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Rattus norvegicus (Rat))
BDBM446091
PNG
(N-(2-{4-[(4-chlorophenyl)methoxy]piperidin-1-yl}-2...)
Show SMILES Cc1ncsc1C(CNC(=O)c1cccc2ncccc12)N1CCC(CC1)OCc1ccc(Cl)cc1
Show InChI InChI=1S/C28H29ClN4O2S/c1-19-27(36-18-32-19)26(16-31-28(34)24-4-2-6-25-23(24)5-3-13-30-25)33-14-11-22(12-15-33)35-17-20-7-9-21(29)10-8-20/h2-10,13,18,22,26H,11-12,14-17H2,1H3,(H,31,34)
PDB

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UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a 1.12E+3n/an/an/an/an/an/a



Axxam S.P.A.

US Patent


Assay Description
Ca2+ influx was measured in HEK-293 cells stably transfected with the receptor using Screen Quest™ Fluo-8 No Wash Calcium Assay Kit (AAt Bioquest®). ...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Rattus norvegicus (Rat))
BDBM446089
PNG
(2-chloro-N-(2-{4-[(3,4-difluorophenyl)methoxy]pipe...)
Show SMILES Cc1ncsc1C(CNC(=O)c1c(F)cccc1Cl)N1CCC(CC1)OCc1ccc(F)c(F)c1
Show InChI InChI=1S/C25H25ClF3N3O2S/c1-15-24(35-14-31-15)22(12-30-25(33)23-18(26)3-2-4-20(23)28)32-9-7-17(8-10-32)34-13-16-5-6-19(27)21(29)11-16/h2-6,11,14,17,22H,7-10,12-13H2,1H3,(H,30,33)
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US Patent
n/an/a 1.17E+3n/an/an/an/an/an/a



Axxam S.P.A.

US Patent


Assay Description
Ca2+ influx was measured in HEK-293 cells stably transfected with the receptor using Screen Quest™ Fluo-8 No Wash Calcium Assay Kit (AAt Bioquest®). ...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Rattus norvegicus (Rat))
BDBM446097
PNG
(2-chloro-N-{2[4-(difluoromethyl)-1,3-thiazol-5-yl]...)
Show SMILES FC(F)c1ncsc1C(CNC(=O)c1c(F)cccc1Cl)N1CCC(CC1)OCc1ccc(F)c(F)c1
Show InChI InChI=1S/C25H23ClF5N3O2S/c26-16-2-1-3-18(28)21(16)25(35)32-11-20(23-22(24(30)31)33-13-37-23)34-8-6-15(7-9-34)36-12-14-4-5-17(27)19(29)10-14/h1-5,10,13,15,20,24H,6-9,11-12H2,(H,32,35)
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n/an/a 1.21E+3n/an/an/an/an/an/a



Axxam S.P.A.

US Patent


Assay Description
Ca2+ influx was measured in HEK-293 cells stably transfected with the receptor using Screen Quest™ Fluo-8 No Wash Calcium Assay Kit (AAt Bioquest®). ...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Rattus norvegicus (Rat))
BDBM446090
PNG
(2-chloro-N-{2-[4-(4-chlorophenoxy)piperidin-1-yl]-...)
Show SMILES Cc1ncsc1C(CNC(=O)c1c(F)cccc1Cl)N1CCC(CC1)Oc1ccc(Cl)cc1
Show InChI InChI=1S/C24H24Cl2FN3O2S/c1-15-23(33-14-29-15)21(13-28-24(31)22-19(26)3-2-4-20(22)27)30-11-9-18(10-12-30)32-17-7-5-16(25)6-8-17/h2-8,14,18,21H,9-13H2,1H3,(H,28,31)
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n/an/a 1.31E+3n/an/an/an/an/an/a



Axxam S.P.A.

US Patent


Assay Description
Ca2+ influx was measured in HEK-293 cells stably transfected with the receptor using Screen Quest™ Fluo-8 No Wash Calcium Assay Kit (AAt Bioquest®). ...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Rattus norvegicus (Rat))
BDBM446098
PNG
(2-chloro-N-{2-[4-(4-chlorophenoxy)piperidin-1-yl]-...)
Show SMILES FC(F)c1ncsc1C(CNC(=O)c1c(F)cccc1Cl)N1CCC(CC1)Oc1ccc(Cl)cc1
Show InChI InChI=1S/C24H22Cl2F3N3O2S/c25-14-4-6-15(7-5-14)34-16-8-10-32(11-9-16)19(22-21(23(28)29)31-13-35-22)12-30-24(33)20-17(26)2-1-3-18(20)27/h1-7,13,16,19,23H,8-12H2,(H,30,33)
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n/an/a 2.02E+3n/an/an/an/an/an/a



Axxam S.P.A.

US Patent


Assay Description
Ca2+ influx was measured in HEK-293 cells stably transfected with the receptor using Screen Quest™ Fluo-8 No Wash Calcium Assay Kit (AAt Bioquest®). ...


US Patent US10669267 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%