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Patent code US10669296

Compile Data Set for Download or QSAR
Found 8 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
lxrbeta


()
BDBM19992
PNG
(2-[3-[3-[[2-chloro-3-(trifluoromethyl)phenyl]methy...)
Show SMILES OC(=O)Cc1cccc(OCCCN(CC(c2ccccc2)c2ccccc2)Cc2cccc(c2Cl)C(F)(F)F)c1
Show InChI InChI=1S/C33H31ClF3NO3/c34-32-27(15-8-17-30(32)33(35,36)37)22-38(18-9-19-41-28-16-7-10-24(20-28)21-31(39)40)23-29(25-11-3-1-4-12-25)26-13-5-2-6-14-26/h1-8,10-17,20,29H,9,18-19,21-23H2,(H,39,40)
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US Patent
n/an/an/an/a 40n/an/an/an/a



Rgenix, Inc.

US Patent


Assay Description
TBD


US Patent US10669296 (2020)

More data for this
Ligand-Target Pair
lxralpha


()
BDBM426493
PNG
(US10543183, Compound SB742881 | US10669296, Compou...)
Show SMILES CC(CCOc1cccc(CC(O)=O)c1)N(CC(c1ccccc1)c1ccccc1)Cc1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C34H33ClF3NO3/c1-24(18-19-42-29-16-8-10-25(20-29)21-32(40)41)39(22-28-15-9-17-31(33(28)35)34(36,37)38)23-30(26-11-4-2-5-12-26)27-13-6-3-7-14-27/h2-17,20,24,30H,18-19,21-23H2,1H3,(H,40,41)
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PC sid
UniChem
US Patent
n/an/an/an/a 74n/an/an/an/a



Rgenix, Inc.

US Patent


Assay Description
TBD


US Patent US10669296 (2020)

More data for this
Ligand-Target Pair
lxrbeta


()
BDBM426493
PNG
(US10543183, Compound SB742881 | US10669296, Compou...)
Show SMILES CC(CCOc1cccc(CC(O)=O)c1)N(CC(c1ccccc1)c1ccccc1)Cc1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C34H33ClF3NO3/c1-24(18-19-42-29-16-8-10-25(20-29)21-32(40)41)39(22-28-15-9-17-31(33(28)35)34(36,37)38)23-30(26-11-4-2-5-12-26)27-13-6-3-7-14-27/h2-17,20,24,30H,18-19,21-23H2,1H3,(H,40,41)
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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 25n/an/an/an/a



Rgenix, Inc.

US Patent


Assay Description
TBD


US Patent US10669296 (2020)

More data for this
Ligand-Target Pair
lxralpha


()
BDBM19992
PNG
(2-[3-[3-[[2-chloro-3-(trifluoromethyl)phenyl]methy...)
Show SMILES OC(=O)Cc1cccc(OCCCN(CC(c2ccccc2)c2ccccc2)Cc2cccc(c2Cl)C(F)(F)F)c1
Show InChI InChI=1S/C33H31ClF3NO3/c34-32-27(15-8-17-30(32)33(35,36)37)22-38(18-9-19-41-28-16-7-10-24(20-28)21-31(39)40)23-29(25-11-3-1-4-12-25)26-13-5-2-6-14-26/h1-8,10-17,20,29H,9,18-19,21-23H2,(H,39,40)
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US Patent
n/an/an/an/a 200n/an/an/an/a



Rgenix, Inc.

US Patent


Assay Description
TBD


US Patent US10669296 (2020)

More data for this
Ligand-Target Pair
lxralpha


()
BDBM26066
PNG
(2-[(2-chloro-4-fluorophenyl)methyl]-3-(4-fluorophe...)
Show SMILES Fc1ccc(cc1)-c1n(Cc2ccc(F)cc2Cl)nc2c(cccc12)C(F)(F)F
Show InChI InChI=1S/C21H12ClF5N2/c22-18-10-15(24)9-6-13(18)11-29-20(12-4-7-14(23)8-5-12)16-2-1-3-17(19(16)28-29)21(25,26)27/h1-10H,11H2
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US Patent
n/an/an/an/a 179n/an/an/an/a



Rgenix, Inc.

US Patent


Assay Description
TBD


US Patent US10669296 (2020)

More data for this
Ligand-Target Pair
lxralpha


()
BDBM19993
PNG
(CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...)
Show SMILES OC(c1ccc(cc1)N(CC(F)(F)F)S(=O)(=O)c1ccccc1)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C17H12F9NO3S/c18-14(19,20)10-27(31(29,30)13-4-2-1-3-5-13)12-8-6-11(7-9-12)15(28,16(21,22)23)17(24,25)26/h1-9,28H,10H2
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US Patent
n/an/an/an/a 20n/an/an/an/a



Rgenix, Inc.

US Patent


Assay Description
TBD


US Patent US10669296 (2020)

More data for this
Ligand-Target Pair
lxrbeta


()
BDBM26066
PNG
(2-[(2-chloro-4-fluorophenyl)methyl]-3-(4-fluorophe...)
Show SMILES Fc1ccc(cc1)-c1n(Cc2ccc(F)cc2Cl)nc2c(cccc12)C(F)(F)F
Show InChI InChI=1S/C21H12ClF5N2/c22-18-10-15(24)9-6-13(18)11-29-20(12-4-7-14(23)8-5-12)16-2-1-3-17(19(16)28-29)21(25,26)27/h1-10H,11H2
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PC cid
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US Patent
n/an/an/an/a 24n/an/an/an/a



Rgenix, Inc.

US Patent


Assay Description
TBD


US Patent US10669296 (2020)

More data for this
Ligand-Target Pair
lxrbeta


()
BDBM19993
PNG
(CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...)
Show SMILES OC(c1ccc(cc1)N(CC(F)(F)F)S(=O)(=O)c1ccccc1)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C17H12F9NO3S/c18-14(19,20)10-27(31(29,30)13-4-2-1-3-5-13)12-8-6-11(7-9-12)15(28,16(21,22)23)17(24,25)26/h1-9,28H,10H2
GoogleScholar
Purchase

CHEMBL
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KEGG
MMDB
PC cid
PC sid
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Patents


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US Patent
n/an/an/an/a 50n/an/an/an/a



Rgenix, Inc.

US Patent


Assay Description
TBD


US Patent US10669296 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%