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Patent code US10675286

Compile Data Set for Download or QSAR

Found 612 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM339972
PNG
(US10329299, Compound 2 | US10675286, Compound 2 | ...)
Show SMILES CC(C)C#Cc1cccc2cc([C@H](C)NC(=O)c3c(N)nn4cccnc34)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1S/C29H24N6O2/c1-18(2)13-14-20-9-7-10-21-17-23(35(29(37)24(20)21)22-11-5-4-6-12-22)19(3)32-28(36)25-26(30)33-34-16-8-15-31-27(25)34/h4-12,15-19H,1-3H3,(H,32,36)/t19-/m0/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10675286 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50192880
PNG
(CHEMBL3984425 | US10329299, Compound 21 | US106752...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3cnn(C)c3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C30H24N8O2/c1-19(34-29(39)26-27(31)35-37-15-7-14-32-28(26)37)24-16-22-9-6-8-21(13-12-20-17-33-36(2)18-20)25(22)30(40)38(24)23-10-4-3-5-11-23/h3-11,14-19H,1-2H3,(H2,31,35)(H,34,39)/t19-/m0/s1
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10675286 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM50192880
PNG
(CHEMBL3984425 | US10329299, Compound 21 | US106752...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3cnn(C)c3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C30H24N8O2/c1-19(34-29(39)26-27(31)35-37-15-7-14-32-28(26)37)24-16-22-9-6-8-21(13-12-20-17-33-36(2)18-20)25(22)30(40)38(24)23-10-4-3-5-11-23/h3-11,14-19H,1-2H3,(H2,31,35)(H,34,39)/t19-/m0/s1
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10675286 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM340015
PNG
(US10329299, Compound 7 | US10675286, Compound 7 | ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3cncn3C)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C30H22N8O2/c1-19(34-29(39)26-27(31)35-37-15-7-14-33-28(26)37)24-16-21-9-6-8-20(12-13-23-17-32-18-36(23)2)25(21)30(40)38(24)22-10-4-3-5-11-22/h3-11,14-19H,1-2H3,(H,34,39)/t19-/m0/s1
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10675286 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM340016
PNG
(US10329299, Compound 8 | US10675286, Compound 8 | ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#CC(C)(C)N)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C29H25N7O2/c1-18(33-27(37)24-25(30)34-35-16-8-15-32-26(24)35)22-17-20-10-7-9-19(13-14-29(2,3)31)23(20)28(38)36(22)21-11-5-4-6-12-21/h4-12,15-18H,31H2,1-3H3,(H,33,37)/t18-/m0/s1
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10675286 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM342526
PNG
(US10329299, Compound 77 | US10675286, Compound 77 ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3ccc(C)nc3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C32H23N7O2/c1-20-12-13-22(19-35-20)14-15-23-8-6-9-24-18-26(39(32(41)27(23)24)25-10-4-3-5-11-25)21(2)36-31(40)28-29(33)37-38-17-7-16-34-30(28)38/h3-13,16-19,21H,1-2H3,(H,36,40)/t21-/m0/s1
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10675286 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM342527
PNG
(US10329299, Compound 78 | US10675286, Compound 78 ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3ncsc3C)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C30H21N7O2S/c1-18(34-29(38)26-27(31)35-36-15-7-14-32-28(26)36)24-16-21-9-6-8-20(12-13-23-19(2)40-17-33-23)25(21)30(39)37(24)22-10-4-3-5-11-22/h3-11,14-18H,1-2H3,(H,34,38)/t18-/m0/s1
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10675286 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM342527
PNG
(US10329299, Compound 78 | US10675286, Compound 78 ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3ncsc3C)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C30H21N7O2S/c1-18(34-29(38)26-27(31)35-36-15-7-14-32-28(26)36)24-16-21-9-6-8-20(12-13-23-19(2)40-17-33-23)25(21)30(39)37(24)22-10-4-3-5-11-22/h3-11,14-18H,1-2H3,(H,34,38)/t18-/m0/s1
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10675286 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM342528
PNG
(US10329299, Compound 79 | US10675286, Compound 79 ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3sc(C)nc3C)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C31H23N7O2S/c1-18(35-30(39)27-28(32)36-37-16-8-15-33-29(27)37)24-17-22-10-7-9-21(13-14-25-19(2)34-20(3)41-25)26(22)31(40)38(24)23-11-5-4-6-12-23/h4-12,15-18H,1-3H3,(H,35,39)/t18-/m0/s1
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10675286 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM342528
PNG
(US10329299, Compound 79 | US10675286, Compound 79 ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3sc(C)nc3C)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C31H23N7O2S/c1-18(35-30(39)27-28(32)36-37-16-8-15-33-29(27)37)24-17-22-10-7-9-21(13-14-25-19(2)34-20(3)41-25)26(22)31(40)38(24)23-11-5-4-6-12-23/h4-12,15-18H,1-3H3,(H,35,39)/t18-/m0/s1
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10675286 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM340017
PNG
(US10329299, Compound 9 | US10675286, Compound 9 | ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#CC3CC3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C29H22N6O2/c1-18(32-28(36)25-26(30)33-34-16-6-15-31-27(25)34)23-17-21-8-5-7-20(14-13-19-11-12-19)24(21)29(37)35(23)22-9-3-2-4-10-22/h2-10,15-19H,11-12H2,1H3,(H,32,36)/t18-/m0/s1
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10675286 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM340022
PNG
(US10329299, Compound 14 | US10675286, Compound 14 ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#CCN3CCCC3=O)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C31H25N7O3/c1-20(34-30(40)27-28(32)35-37-18-8-15-33-29(27)37)24-19-22-10-5-9-21(11-6-16-36-17-7-14-25(36)39)26(22)31(41)38(24)23-12-3-2-4-13-23/h2-5,8-10,12-13,15,18-20H,7,14,16-17H2,1H3,(H,34,40)/t20-/m0/s1
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10675286 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM340023
PNG
(US10329299, Compound 15 | US10675286, Compound 15 ...)
Show SMILES C[C@@H](O)C#Cc1cccc2cc([C@H](C)NC(=O)c3c(N)nn4cccnc34)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1S/C28H22N6O3/c1-17(35)12-13-19-8-6-9-20-16-22(34(28(37)23(19)20)21-10-4-3-5-11-21)18(2)31-27(36)24-25(29)32-33-15-7-14-30-26(24)33/h3-11,14-18,35H,1-2H3,(H,31,36)/t17-,18+/m1/s1
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10675286 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM342534
PNG
(US10329299, Compound 85 | US10675286, Compound 85 ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#CC3CCN(C)CC3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C32H29N7O2/c1-21(35-31(40)28-29(33)36-38-17-7-16-34-30(28)38)26-20-24-9-6-8-23(13-12-22-14-18-37(2)19-15-22)27(24)32(41)39(26)25-10-4-3-5-11-25/h3-11,16-17,20-22H,14-15,18-19H2,1-2H3,(H,35,40)/t21-/m0/s1
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10675286 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM342534
PNG
(US10329299, Compound 85 | US10675286, Compound 85 ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#CC3CCN(C)CC3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C32H29N7O2/c1-21(35-31(40)28-29(33)36-38-17-7-16-34-30(28)38)26-20-24-9-6-8-23(13-12-22-14-18-37(2)19-15-22)27(24)32(41)39(26)25-10-4-3-5-11-25/h3-11,16-17,20-22H,14-15,18-19H2,1-2H3,(H,35,40)/t21-/m0/s1
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10675286 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM342534
PNG
(US10329299, Compound 85 | US10675286, Compound 85 ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#CC3CCN(C)CC3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C32H29N7O2/c1-21(35-31(40)28-29(33)36-38-17-7-16-34-30(28)38)26-20-24-9-6-8-23(13-12-22-14-18-37(2)19-15-22)27(24)32(41)39(26)25-10-4-3-5-11-25/h3-11,16-17,20-22H,14-15,18-19H2,1-2H3,(H,35,40)/t21-/m0/s1
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10675286 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM342536
PNG
(US10329299, Compound 87 | US10675286, Compound 87 ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(\C=C\c3ccccc3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C32H24N6O2/c1-21(35-31(39)28-29(33)36-37-19-9-18-34-30(28)37)26-20-24-13-8-12-23(17-16-22-10-4-2-5-11-22)27(24)32(40)38(26)25-14-6-3-7-15-25/h2-21H,1H3,(H,35,39)/b17-16+/t21-/m0/s1
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10675286 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM342536
PNG
(US10329299, Compound 87 | US10675286, Compound 87 ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(\C=C\c3ccccc3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C32H24N6O2/c1-21(35-31(39)28-29(33)36-37-19-9-18-34-30(28)37)26-20-24-13-8-12-23(17-16-22-10-4-2-5-11-22)27(24)32(40)38(26)25-14-6-3-7-15-25/h2-21H,1H3,(H,35,39)/b17-16+/t21-/m0/s1
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10675286 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM342540
PNG
(US10329299, Compound 91 | US10675286, Compound 91 ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(CC(=O)c3cnn(C)c3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C30H24N8O3/c1-18(34-29(40)26-27(31)35-37-13-7-12-32-28(26)37)23-14-19-8-6-9-20(15-24(39)21-16-33-36(2)17-21)25(19)30(41)38(23)22-10-4-3-5-11-22/h3-14,16-18H,15H2,1-2H3,(H,34,40)/t18-/m0/s1
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10675286 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM342543
PNG
(US10329299, Compound 94 | US10675286, Compound 94 ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3cnn(C)c3)c2c(=O)n1C
Show InChI InChI=1S/C25H20N8O2/c1-15(29-24(34)21-22(26)30-33-11-5-10-27-23(21)33)19-12-18-7-4-6-17(20(18)25(35)32(19)3)9-8-16-13-28-31(2)14-16/h4-7,10-15H,1-3H3,(H,29,34)/t15-/m0/s1
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10675286 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM342543
PNG
(US10329299, Compound 94 | US10675286, Compound 94 ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3cnn(C)c3)c2c(=O)n1C
Show InChI InChI=1S/C25H20N8O2/c1-15(29-24(34)21-22(26)30-33-11-5-10-27-23(21)33)19-12-18-7-4-6-17(20(18)25(35)32(19)3)9-8-16-13-28-31(2)14-16/h4-7,10-15H,1-3H3,(H,29,34)/t15-/m0/s1
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10675286 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM342545
PNG
(US10329299, Compound 96 | US10675286, Compound 96 ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3cnn(C)c3)c2c(=O)n1-c1ccc(F)cc1
Show InChI InChI=1S/C30H21FN8O2/c1-18(35-29(40)26-27(32)36-38-14-4-13-33-28(26)38)24-15-21-6-3-5-20(8-7-19-16-34-37(2)17-19)25(21)30(41)39(24)23-11-9-22(31)10-12-23/h3-6,9-18H,1-2H3,(H,35,40)/t18-/m0/s1
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10675286 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM450258
PNG
(US10675286, Compound 22)
Show SMILES COC(C)C#Cc1cccc2cc([C@H](C)NC(=O)c3c(N)nn4cccnc34)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1S/C29H26N6O3/c1-18(38-3)13-14-20-9-7-10-21-17-23(35(29(37)24(20)21)22-11-5-4-6-12-22)19(2)32-28(36)25-26(30)33-34-16-8-15-31-27(25)34/h4-12,15-19H,1-3H3,(H2,30,33)(H,32,36)/t18?,19-/m0/s1
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10675286 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM342453
PNG
(US10329299, Compound 24 | US10675286, Compound 24 ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#CC3CC3)c2c(=O)n1C1CC1
Show InChI InChI=1S/C26H22N6O2/c1-15(29-25(33)22-23(27)30-31-13-3-12-28-24(22)31)20-14-18-5-2-4-17(9-8-16-6-7-16)21(18)26(34)32(20)19-10-11-19/h2-5,12-16,19H,6-7,10-11H2,1H3,(H,29,33)/t15-/m0/s1
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10675286 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50192911
PNG
(CHEMBL3955769 | US10329299, Compound 26 | US106752...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3ccncc3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C31H23N7O2/c1-20(35-30(39)27-28(32)36-37-18-6-15-34-29(27)37)25-19-23-8-5-7-22(12-11-21-13-16-33-17-14-21)26(23)31(40)38(25)24-9-3-2-4-10-24/h2-10,13-20H,1H3,(H2,32,36)(H,35,39)/t20-/m0/s1
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10675286 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM50192911
PNG
(CHEMBL3955769 | US10329299, Compound 26 | US106752...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3ccncc3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C31H23N7O2/c1-20(35-30(39)27-28(32)36-37-18-6-15-34-29(27)37)25-19-23-8-5-7-22(12-11-21-13-16-33-17-14-21)26(23)31(40)38(25)24-9-3-2-4-10-24/h2-10,13-20H,1H3,(H2,32,36)(H,35,39)/t20-/m0/s1
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10675286 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM342458
PNG
(US10329299, Compound 27 | US10675286, Compound 27 ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#CC3CCOCC3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C31H26N6O3/c1-20(34-30(38)27-28(32)35-36-16-6-15-33-29(27)36)25-19-23-8-5-7-22(12-11-21-13-17-40-18-14-21)26(23)31(39)37(25)24-9-3-2-4-10-24/h2-10,15-16,19-21H,13-14,17-18H2,1H3,(H,34,38)/t20-/m0/s1
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10675286 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM342546
PNG
(US10329299, Compound 97 | US10675286, Compound 97 ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3cnn(C)c3)c2c(=O)n1-c1ccc(F)c(F)c1
Show InChI InChI=1S/C30H20F2N8O2/c1-17(36-29(41)26-27(33)37-39-12-4-11-34-28(26)39)24-13-20-6-3-5-19(8-7-18-15-35-38(2)16-18)25(20)30(42)40(24)21-9-10-22(31)23(32)14-21/h3-6,9-17H,1-2H3,(H,36,41)/t17-/m0/s1
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10675286 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM342549
PNG
(US10329299, Compound 100 | US10675286, Compound 10...)
Show SMILES CNS(=O)(=O)CCn1c(cc2cccc(C#Cc3cnn(C)c3)c2c1=O)[C@H](C)NC(=O)c1c(N)nn2cccnc12
Show InChI InChI=1S/C27H27N9O4S/c1-17(32-26(37)23-24(28)33-36-11-5-10-30-25(23)36)21-14-20-7-4-6-19(9-8-18-15-31-34(3)16-18)22(20)27(38)35(21)12-13-41(39,40)29-2/h4-7,10-11,14-17,29H,12-13H2,1-3H3,(H2,28,33)(H,32,37)/t17-/m0/s1
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10675286 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM342550
PNG
(US10329299, Compound 101 | US10675286, Compound 10...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3cnn(C)c3)c2c(=O)n1-c1ccccc1C
Show InChI InChI=1S/C31H24N8O2/c1-19-8-4-5-11-24(19)39-25(20(2)35-30(40)27-28(32)36-38-15-7-14-33-29(27)38)16-23-10-6-9-22(26(23)31(39)41)13-12-21-17-34-37(3)18-21/h4-11,14-18,20H,1-3H3,(H,35,40)/t20-/m0/s1
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10675286 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM342551
PNG
(US10329299, Compound 102 | US10675286, Compound 10...)
Show SMILES C[C@H](NC(=O)c1cnn2c(C)ccnc12)c1cc2cccc(C#Cc3cnn(C)c3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C31H25N7O2/c1-20-14-15-32-29-26(18-34-38(20)29)30(39)35-21(2)27-16-24-9-7-8-23(13-12-22-17-33-36(3)19-22)28(24)31(40)37(27)25-10-5-4-6-11-25/h4-11,14-19,21H,1-3H3,(H,35,39)/t21-/m0/s1
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10675286 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50192894
PNG
(CHEMBL3893430 | US10329299, Compound 32 | US106752...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3ccccn3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C31H23N7O2/c1-20(35-30(39)27-28(32)36-37-18-8-17-34-29(27)37)25-19-22-10-7-9-21(14-15-23-11-5-6-16-33-23)26(22)31(40)38(25)24-12-3-2-4-13-24/h2-13,16-20H,1H3,(H2,32,36)(H,35,39)/t20-/m0/s1
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10675286 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM50192894
PNG
(CHEMBL3893430 | US10329299, Compound 32 | US106752...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3ccccn3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C31H23N7O2/c1-20(35-30(39)27-28(32)36-37-18-8-17-34-29(27)37)25-19-22-10-7-9-21(14-15-23-11-5-6-16-33-23)26(22)31(40)38(25)24-12-3-2-4-13-24/h2-13,16-20H,1H3,(H2,32,36)(H,35,39)/t20-/m0/s1
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10675286 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM342556
PNG
(US10329299, Compound 107 | US10675286, Compound 10...)
Show SMILES Cn1cc(cn1)C#Cc1cccc2cc(CNC(=O)c3c(N)nn4cccnc34)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1S/C29H22N8O2/c1-35-18-19(16-33-35)11-12-20-7-5-8-21-15-23(37(29(39)24(20)21)22-9-3-2-4-10-22)17-32-28(38)25-26(30)34-36-14-6-13-31-27(25)36/h2-10,13-16,18H,17H2,1H3,(H2,30,34)(H,32,38)
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10675286 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50192880
PNG
(CHEMBL3984425 | US10329299, Compound 21 | US106752...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3cnn(C)c3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C30H24N8O2/c1-19(34-29(39)26-27(31)35-37-15-7-14-32-28(26)37)24-16-22-9-6-8-21(13-12-20-17-33-36(2)18-20)25(22)30(40)38(24)23-10-4-3-5-11-23/h3-11,14-19H,1-2H3,(H2,31,35)(H,34,39)/t19-/m0/s1
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10675286 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM342466
PNG
(US10329299, Compound 35 | US10675286, Compound 35 ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3cnn(C)c3C)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C31H24N8O2/c1-19(35-30(40)27-28(32)36-38-16-8-15-33-29(27)38)25-17-22-10-7-9-21(13-14-23-18-34-37(3)20(23)2)26(22)31(41)39(25)24-11-5-4-6-12-24/h4-12,15-19H,1-3H3,(H,35,40)/t19-/m0/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10675286 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM342467
PNG
(US10329299, Compound 36 | US10675286, Compound 36 ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#CC=O)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C27H18N6O3/c1-17(30-26(35)23-24(28)31-32-14-7-13-29-25(23)32)21-16-19-9-5-8-18(10-6-15-34)22(19)27(36)33(21)20-11-3-2-4-12-20/h2-5,7-9,11-17H,1H3,(H,30,35)/t17-/m0/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10675286 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM402892
PNG
(US10329299, Compound 42 | US10675286, Compound 42)
Show SMILES C[C@H](NC(=O)c1cncc2cccnc12)c1cc2cccc(C#Cc3cnn(C)c3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C32H24N6O2/c1-21(36-31(39)27-19-33-18-25-10-7-15-34-30(25)27)28-16-24-9-6-8-23(14-13-22-17-35-37(2)20-22)29(24)32(40)38(28)26-11-4-3-5-12-26/h3-12,15-21H,1-2H3,(H,36,39)/t21-/m0/s1
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10675286 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM402893
PNG
(US10329299, Compound 43 | US10675286, Compound 43)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3ccn[nH]3)c2c(=O)n1-c1ccccc1
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n/an/a 2.00E+3n/an/an/an/an/an/a



Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10675286 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM342476
PNG
(US10329299, Compound 44 | US10675286, Compound 44 ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3cnn(C)c3)c2c(=O)[nH]1
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10675286 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM342478
PNG
(US10329299, Compound 46 | US10675286, Compound 46 ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1nc2cccc(C#C)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C25H17N7O2/c1-3-16-9-7-12-18-19(16)25(34)32(17-10-5-4-6-11-17)22(29-18)15(2)28-24(33)20-21(26)30-31-14-8-13-27-23(20)31/h1,4-15H,2H3,(H,28,33)/t15-/m0/s1
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10675286 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM342479
PNG
(US10329299, Compound 47 | US10675286, Compound 47 ...)
Show SMILES C[C@H](NC(=O)c1nccnc1N)c1nc2cccc(C#C)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C23H16N6O2/c1-3-15-8-7-11-17-18(15)23(31)29(16-9-5-4-6-10-16)21(28-17)14(2)27-22(30)19-20(24)26-13-12-25-19/h1,4-14H,2H3,(H,27,30)/t14-/m0/s1
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10675286 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM342480
PNG
(US10329299, Compound 48 | US10675286, Compound 48 ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1nc2cccc(C#C)c2c(=O)n1C
Show InChI InChI=1S/C20H15N7O2/c1-4-12-7-5-8-13-14(12)20(29)26(3)17(24-13)11(2)23-19(28)15-16(21)25-27-10-6-9-22-18(15)27/h1,5-11H,2-3H3,(H,23,28)/t11-/m0/s1
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10675286 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM342481
PNG
(US10329299, Compound 49 | US10675286, Compound 49 ...)
Show SMILES C[C@H](NC(=O)c1nccnc1N)c1nc2cccc(C#C)c2c(=O)n1-c1ccc(F)cc1
Show InChI InChI=1S/C23H15FN6O2/c1-3-14-5-4-6-17-18(14)23(32)30(16-9-7-15(24)8-10-16)21(29-17)13(2)28-22(31)19-20(25)27-12-11-26-19/h1,4-13H,2H3,(H,28,31)/t13-/m0/s1
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10675286 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM342483
PNG
(US10675286, Compound 51 | US9775844, Compound 51)
Show SMILES CC#Cc1cccc2cc(C(C)NC(=O)c3c(N)nn4cccnc34)c(nc12)-c1ccccc1
Show InChI InChI=1S/C27H20N6O/c1-3-9-18-12-7-13-20-16-21(24(31-23(18)20)19-10-5-4-6-11-19)17(2)30-27(34)22-25(28)32-33-15-8-14-29-26(22)33/h4-8,10-17H,1-2H3,(H,30,34)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10675286 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50192885
PNG
(CHEMBL3923629 | US10329299, Compound 54 | US106752...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3cscn3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C29H21N7O2S/c1-18(33-28(37)25-26(30)34-35-14-6-13-31-27(25)35)23-15-20-8-5-7-19(11-12-21-16-39-17-32-21)24(20)29(38)36(23)22-9-3-2-4-10-22/h2-10,13-18H,1H3,(H2,30,34)(H,33,37)/t18-/m0/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10675286 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM342488
PNG
(US10329299, Compound 55 | US10675286, Compound 55 ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1nc2cccc(C#Cc3cnn(C)c3)c2c(=O)n1C
Show InChI InChI=1S/C24H19N9O2/c1-14(28-23(34)19-20(25)30-33-11-5-10-26-22(19)33)21-29-17-7-4-6-16(18(17)24(35)32(21)3)9-8-15-12-27-31(2)13-15/h4-7,10-14H,1-3H3,(H,28,34)/t14-/m0/s1
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10675286 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM342490
PNG
(US10329299, Compound 57 | US10675286, Compound 57 ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#CCN(C)C)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C29H25N7O2/c1-19(32-28(37)25-26(30)33-35-17-9-15-31-27(25)35)23-18-21-11-7-10-20(12-8-16-34(2)3)24(21)29(38)36(23)22-13-5-4-6-14-22/h4-7,9-11,13-15,17-19H,16H2,1-3H3,(H,32,37)/t19-/m0/s1
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10675286 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM50192908
PNG
(CHEMBL3895629 | US10329299, Compound 59 | US106752...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3nccs3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C29H21N7O2S/c1-18(33-28(37)25-26(30)34-35-15-6-13-32-27(25)35)22-17-20-8-5-7-19(11-12-23-31-14-16-39-23)24(20)29(38)36(22)21-9-3-2-4-10-21/h2-10,13-18H,1H3,(H2,30,34)(H,33,37)/t18-/m0/s1
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10675286 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM342496
PNG
(US10329299, Compound 62 | US10675286, Compound 62 ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#CC3(O)CN4CCC3CC4)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C33H29N7O3/c1-21(36-31(41)28-29(34)37-39-16-6-15-35-30(28)39)26-19-23-8-5-7-22(11-14-33(43)20-38-17-12-24(33)13-18-38)27(23)32(42)40(26)25-9-3-2-4-10-25/h2-10,15-16,19,21,24,43H,12-13,17-18,20H2,1H3,(H,36,41)/t21-,33?/m0/s1
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10675286 (2020)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%