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Patent code US10676431

Compile Data Set for Download or QSAR

Found 270 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
fMet-Leu-Phe receptor


(Homo sapiens (Human))
BDBM450240
PNG
(US10676431, Example 5)
Show SMILES CS(=O)(=O)Nc1ccccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3ccc(Cl)cc3F)C2=O)c(F)c1F
Show InChI InChI=1S/C24H20ClF3N4O4S/c1-37(35,36)31-17-5-3-2-4-14(17)15-7-9-20(22(28)21(15)27)32-11-10-19(23(32)33)30-24(34)29-18-8-6-13(25)12-16(18)26/h2-9,12,19,31H,10-11H2,1H3,(H2,29,30,34)/t19-/m1/s1
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n/an/an/an/a 230n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450245
PNG
(US10676431, Example 9)
Show SMILES Fc1cc(Cl)ccc1NC(=O)N[C@@H]1CCN(C1=O)c1ccc(c(F)c1F)-c1ccccc1C#N
Show InChI InChI=1S/C24H16ClF3N4O2/c25-14-5-7-18(17(26)11-14)30-24(34)31-19-9-10-32(23(19)33)20-8-6-16(21(27)22(20)28)15-4-2-1-3-13(15)12-29/h1-8,11,19H,9-10H2,(H2,30,31,34)/t19-/m1/s1
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n/an/an/an/a 2.10n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor


(Homo sapiens (Human))
BDBM450247
PNG
(US10676431, Example 11)
Show SMILES CS(=O)(=O)c1ccccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3ccc(cc3)C(F)(F)F)C2=O)c(F)c1F
Show InChI InChI=1S/C25H20F5N3O4S/c1-38(36,37)20-5-3-2-4-16(20)17-10-11-19(22(27)21(17)26)33-13-12-18(23(33)34)32-24(35)31-15-8-6-14(7-9-15)25(28,29)30/h2-11,18H,12-13H2,1H3,(H2,31,32,35)/t18-/m1/s1
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n/an/an/an/a 290n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450251
PNG
(US10676431, Example 15)
Show SMILES CS(=O)(=O)Nc1ccccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3cnc(Cl)cn3)C2=O)c(F)c1F
Show InChI InChI=1S/C22H19ClF2N6O4S/c1-36(34,35)30-14-5-3-2-4-12(14)13-6-7-16(20(25)19(13)24)31-9-8-15(21(31)32)28-22(33)29-18-11-26-17(23)10-27-18/h2-7,10-11,15,30H,8-9H2,1H3,(H2,27,28,29,33)/t15-/m1/s1
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n/an/an/an/a 10n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor


(Homo sapiens (Human))
BDBM450252
PNG
(US10676431, Example 16)
Show SMILES Fc1ccccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3ccc(Cl)cc3)C2=O)c(F)c1F
Show InChI InChI=1S/C23H17ClF3N3O2/c24-13-5-7-14(8-6-13)28-23(32)29-18-11-12-30(22(18)31)19-10-9-16(20(26)21(19)27)15-3-1-2-4-17(15)25/h1-10,18H,11-12H2,(H2,28,29,32)/t18-/m1/s1
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n/an/an/an/a 120n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor


(Homo sapiens (Human))
BDBM450253
PNG
(US10676431, Example 17)
Show SMILES CS(=O)(=O)Nc1ccccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3ccc(Cl)cn3)C2=O)c(F)c1F
Show InChI InChI=1S/C23H20ClF2N5O4S/c1-36(34,35)30-16-5-3-2-4-14(16)15-7-8-18(21(26)20(15)25)31-11-10-17(22(31)32)28-23(33)29-19-9-6-13(24)12-27-19/h2-9,12,17,30H,10-11H2,1H3,(H2,27,28,29,33)/t17-/m1/s1
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n/an/an/an/a 4.10E+3n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450256
PNG
(US10676431, Example 20)
Show SMILES CS(=O)(=O)Nc1ccccc1-c1ccc(cc1)N1CC[C@@H](NC(=O)Nc2ccc(nc2)C(F)(F)F)C1=O
Show InChI InChI=1S/C24H22F3N5O4S/c1-37(35,36)31-19-5-3-2-4-18(19)15-6-9-17(10-7-15)32-13-12-20(22(32)33)30-23(34)29-16-8-11-21(28-14-16)24(25,26)27/h2-11,14,20,31H,12-13H2,1H3,(H2,29,30,34)/t20-/m1/s1
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n/an/an/an/a 24n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450257
PNG
(US10676431, Example 21)
Show SMILES Fc1cc(Cl)ccc1NC(=O)N[C@@H]1CCN(C1=O)c1ccc(c(F)c1F)-c1ccccc1F
Show InChI InChI=1S/C23H16ClF4N3O2/c24-12-5-7-17(16(26)11-12)29-23(33)30-18-9-10-31(22(18)32)19-8-6-14(20(27)21(19)28)13-3-1-2-4-15(13)25/h1-8,11,18H,9-10H2,(H2,29,30,33)/t18-/m1/s1
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n/an/an/an/a 31n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor


(Homo sapiens (Human))
BDBM450262
PNG
(US10676431, Example 25)
Show SMILES CP(C)(=O)c1ccccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3ccc(Cl)cc3F)C2=O)c(F)c1F
Show InChI InChI=1S/C25H22ClF3N3O3P/c1-36(2,35)21-6-4-3-5-15(21)16-8-10-20(23(29)22(16)28)32-12-11-19(24(32)33)31-25(34)30-18-9-7-14(26)13-17(18)27/h3-10,13,19H,11-12H2,1-2H3,(H2,30,31,34)/t19-/m1/s1
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n/an/an/an/a 260n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor


(Homo sapiens (Human))
BDBM450267
PNG
(US10676431, Example 30)
Show SMILES COC[C@@H]1C[C@@H](NC(=O)Nc2ccc(Cl)cc2F)C(=O)N1c1ccc(c(F)c1F)-c1ccccc1P(C)(C)=O
Show InChI InChI=1S/C27H26ClF3N3O4P/c1-38-14-16-13-21(33-27(36)32-20-10-8-15(28)12-19(20)29)26(35)34(16)22-11-9-18(24(30)25(22)31)17-6-4-5-7-23(17)39(2,3)37/h4-12,16,21H,13-14H2,1-3H3,(H2,32,33,36)/t16-,21+/m0/s1
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n/an/an/an/a 83n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor


(Homo sapiens (Human))
BDBM450270
PNG
(US10676431, Example 33)
Show SMILES CS(=O)(=O)Nc1ccccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3ccc(cc3F)C(F)(F)F)C2=O)c(F)c1F
Show InChI InChI=1S/C25H20F6N4O4S/c1-40(38,39)34-17-5-3-2-4-14(17)15-7-9-20(22(28)21(15)27)35-11-10-19(23(35)36)33-24(37)32-18-8-6-13(12-16(18)26)25(29,30)31/h2-9,12,19,34H,10-11H2,1H3,(H2,32,33,37)/t19-/m1/s1
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n/an/an/an/a 470n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450275
PNG
(US10676431, Example 38)
Show SMILES CC(C)c1cc(ccc1N1CC[C@@H](NC(=O)Nc2ccc(Cl)cc2F)C1=O)-c1ccccc1CO
Show InChI InChI=1S/C27H27ClFN3O3/c1-16(2)21-13-17(20-6-4-3-5-18(20)15-33)7-10-25(21)32-12-11-24(26(32)34)31-27(35)30-23-9-8-19(28)14-22(23)29/h3-10,13-14,16,24,33H,11-12,15H2,1-2H3,(H2,30,31,35)/t24-/m1/s1
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n/an/an/an/a 3.5n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450279
PNG
(US10676431, Example 42)
Show SMILES CS(=O)(=O)c1ccccc1-c1ccc(N2[C@H](CO)C[C@@H](NC(=O)Nc3ccc(Cl)cc3F)C2=O)c(F)c1F
Show InChI InChI=1S/C25H21ClF3N3O5S/c1-38(36,37)21-5-3-2-4-15(21)16-7-9-20(23(29)22(16)28)32-14(12-33)11-19(24(32)34)31-25(35)30-18-8-6-13(26)10-17(18)27/h2-10,14,19,33H,11-12H2,1H3,(H2,30,31,35)/t14-,19+/m0/s1
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n/an/an/an/a 1n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor


(Homo sapiens (Human))
BDBM450283
PNG
(US10676431, Example 46)
Show SMILES CP(C)(=O)c1ccccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3ccc(Cl)cc3F)C2=O)c(c1)C1CC1
Show InChI InChI=1S/C28H28ClFN3O3P/c1-37(2,36)26-6-4-3-5-20(26)18-9-12-25(21(15-18)17-7-8-17)33-14-13-24(27(33)34)32-28(35)31-23-11-10-19(29)16-22(23)30/h3-6,9-12,15-17,24H,7-8,13-14H2,1-2H3,(H2,31,32,35)/t24-/m1/s1
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n/an/an/an/a 93n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor


(Homo sapiens (Human))
BDBM450285
PNG
(US10676431, Example 48)
Show SMILES CS(=O)(=O)Nc1ncccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3ccc(Cl)cc3F)C2=O)c(c1)C1CC1
Show InChI InChI=1S/C26H25ClFN5O4S/c1-38(36,37)32-24-18(3-2-11-29-24)16-6-9-23(19(13-16)15-4-5-15)33-12-10-22(25(33)34)31-26(35)30-21-8-7-17(27)14-20(21)28/h2-3,6-9,11,13-15,22H,4-5,10,12H2,1H3,(H,29,32)(H2,30,31,35)/t22-/m1/s1
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n/an/an/an/a 110n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450287
PNG
(US10676431, Example 50)
Show SMILES CC(N)c1cccc(c1)-c1ccc(N2CC[C@@H](NC(=O)Nc3ccc(Cl)cc3F)C2=O)c(F)c1F
Show InChI InChI=1S/C25H22ClF3N4O2/c1-13(30)14-3-2-4-15(11-14)17-6-8-21(23(29)22(17)28)33-10-9-20(24(33)34)32-25(35)31-19-7-5-16(26)12-18(19)27/h2-8,11-13,20H,9-10,30H2,1H3,(H2,31,32,35)/t13?,20-/m1/s1
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n/an/an/an/a 14n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor


(Homo sapiens (Human))
BDBM450292
PNG
(US10676431, Example 55)
Show SMILES CP(C)(=O)c1ccccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3ncc(cc3F)C(F)(F)F)C2=O)c(F)c1F
Show InChI InChI=1S/C25H21F6N4O3P/c1-39(2,38)19-6-4-3-5-14(19)15-7-8-18(21(28)20(15)27)35-10-9-17(23(35)36)33-24(37)34-22-16(26)11-13(12-32-22)25(29,30)31/h3-8,11-12,17H,9-10H2,1-2H3,(H2,32,33,34,37)/t17-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor


(Homo sapiens (Human))
BDBM450298
PNG
(US10676431, Example 61)
Show SMILES CC(C)c1cc(ccc1N1CC[C@@H](NC(=O)Nc2ncc(Cl)cc2F)C1=O)-c1ccccc1P(C)(C)=O
Show InChI InChI=1S/C27H29ClFN4O3P/c1-16(2)20-13-17(19-7-5-6-8-24(19)37(3,4)36)9-10-23(20)33-12-11-22(26(33)34)31-27(35)32-25-21(29)14-18(28)15-30-25/h5-10,13-16,22H,11-12H2,1-4H3,(H2,30,31,32,35)/t22-/m1/s1
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n/an/an/an/a 370n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor


(Homo sapiens (Human))
BDBM450299
PNG
(US10676431, Example 62)
Show SMILES CP(C)(=O)c1ccccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3cnc(Cl)cn3)C2=O)c(c1)C1CC1
Show InChI InChI=1S/C26H27ClN5O3P/c1-36(2,35)22-6-4-3-5-18(22)17-9-10-21(19(13-17)16-7-8-16)32-12-11-20(25(32)33)30-26(34)31-24-15-28-23(27)14-29-24/h3-6,9-10,13-16,20H,7-8,11-12H2,1-2H3,(H2,29,30,31,34)/t20-/m1/s1
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n/an/an/an/a 720n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450309
PNG
(US10676431, Example 72)
Show SMILES CP(C)(=O)c1c(F)cccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3ccc(cc3F)C(F)(F)F)C2=O)c(F)c1F
Show InChI InChI=1S/C26H21F7N3O3P/c1-40(2,39)23-15(4-3-5-16(23)27)14-7-9-20(22(30)21(14)29)36-11-10-19(24(36)37)35-25(38)34-18-8-6-13(12-17(18)28)26(31,32)33/h3-9,12,19H,10-11H2,1-2H3,(H2,34,35,38)/t19-/m1/s1
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n/an/an/an/a 0.610n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor


(Homo sapiens (Human))
BDBM450310
PNG
(US10676431, Example 73)
Show SMILES CP(C)(=O)c1ncccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3ccc(cc3F)C(F)(F)F)C2=O)c(F)c1F
Show InChI InChI=1S/C25H21F6N4O3P/c1-39(2,38)22-15(4-3-10-32-22)14-6-8-19(21(28)20(14)27)35-11-9-18(23(35)36)34-24(37)33-17-7-5-13(12-16(17)26)25(29,30)31/h3-8,10,12,18H,9,11H2,1-2H3,(H2,33,34,37)/t18-/m1/s1
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n/an/an/an/a 170n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor


(Homo sapiens (Human))
BDBM450312
PNG
(US10676431, Example 75)
Show SMILES CCP(=O)(CC)c1ccccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3ccc(Cl)cc3F)C2=O)c(F)c1F
Show InChI InChI=1S/C27H26ClF3N3O3P/c1-3-38(37,4-2)23-8-6-5-7-17(23)18-10-12-22(25(31)24(18)30)34-14-13-21(26(34)35)33-27(36)32-20-11-9-16(28)15-19(20)29/h5-12,15,21H,3-4,13-14H2,1-2H3,(H2,32,33,36)/t21-/m1/s1
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n/an/an/an/a 1.18E+3n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450314
PNG
(US10676431, Example 77)
Show SMILES CP(C)(=O)c1ccccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3ccc(cc3F)C(F)(F)F)C2=O)c(F)c1Cl
Show InChI InChI=1S/C26H22ClF5N3O3P/c1-39(2,38)21-6-4-3-5-15(21)16-8-10-20(23(29)22(16)27)35-12-11-19(24(35)36)34-25(37)33-18-9-7-14(13-17(18)28)26(30,31)32/h3-10,13,19H,11-12H2,1-2H3,(H2,33,34,37)/t19-/m1/s1
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n/an/an/an/a 1.20n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor


(Homo sapiens (Human))
BDBM450320
PNG
(US10676431, Example 83)
Show SMILES CP(C)(=O)c1ccccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3ccc(Cl)cc3F)C2=O)c(F)c1C(F)(F)F
Show InChI InChI=1S/C26H22ClF5N3O3P/c1-39(2,38)21-6-4-3-5-15(21)16-8-10-20(23(29)22(16)26(30,31)32)35-12-11-19(24(35)36)34-25(37)33-18-9-7-14(27)13-17(18)28/h3-10,13,19H,11-12H2,1-2H3,(H2,33,34,37)/t19-/m1/s1
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n/an/an/an/a 0.990n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450329
PNG
(US10676431, Example 92)
Show SMILES CP(C)(=O)c1ccccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3ccc(cc3F)C(F)(F)F)C2=O)c(c1F)C(F)(F)F
Show InChI InChI=1S/C27H22F8N3O3P/c1-42(2,41)21-6-4-3-5-15(21)16-8-10-20(22(23(16)29)27(33,34)35)38-12-11-19(24(38)39)37-25(40)36-18-9-7-14(13-17(18)28)26(30,31)32/h3-10,13,19H,11-12H2,1-2H3,(H2,36,37,40)/t19-/m1/s1
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n/an/an/an/a 8.30n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450336
PNG
(US10676431, Example 99)
Show SMILES CP(C)(=O)c1ccccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3ccc(Cl)cc3F)C2=O)c(Cl)c1F
Show InChI InChI=1S/C25H22Cl2F2N3O3P/c1-36(2,35)21-6-4-3-5-15(21)16-8-10-20(22(27)23(16)29)32-12-11-19(24(32)33)31-25(34)30-18-9-7-14(26)13-17(18)28/h3-10,13,19H,11-12H2,1-2H3,(H2,30,31,34)/t19-/m1/s1
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n/an/an/an/a 0.790n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor


(Homo sapiens (Human))
BDBM450336
PNG
(US10676431, Example 99)
Show SMILES CP(C)(=O)c1ccccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3ccc(Cl)cc3F)C2=O)c(Cl)c1F
Show InChI InChI=1S/C25H22Cl2F2N3O3P/c1-36(2,35)21-6-4-3-5-15(21)16-8-10-20(22(27)23(16)29)32-12-11-19(24(32)33)31-25(34)30-18-9-7-14(26)13-17(18)28/h3-10,13,19H,11-12H2,1-2H3,(H2,30,31,34)/t19-/m1/s1
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n/an/an/an/a 240n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450341
PNG
(US10676431, Example 104 | US10676431, Example 105)
Show SMILES CCOP(C)(=O)c1ccccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3ccc(cc3F)C(F)(F)F)C2=O)c(F)c1F
Show InChI InChI=1S/C27H24F6N3O4P/c1-3-40-41(2,39)22-7-5-4-6-16(22)17-9-11-21(24(30)23(17)29)36-13-12-20(25(36)37)35-26(38)34-19-10-8-15(14-18(19)28)27(31,32)33/h4-11,14,20H,3,12-13H2,1-2H3,(H2,34,35,38)/t20-,41?/m1/s1
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n/an/an/an/a 5.20n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor


(Homo sapiens (Human))
BDBM450341
PNG
(US10676431, Example 104 | US10676431, Example 105)
Show SMILES CCOP(C)(=O)c1ccccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3ccc(cc3F)C(F)(F)F)C2=O)c(F)c1F
Show InChI InChI=1S/C27H24F6N3O4P/c1-3-40-41(2,39)22-7-5-4-6-16(22)17-9-11-21(24(30)23(17)29)36-13-12-20(25(36)37)35-26(38)34-19-10-8-15(14-18(19)28)27(31,32)33/h4-11,14,20H,3,12-13H2,1-2H3,(H2,34,35,38)/t20-,41?/m1/s1
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n/an/an/an/a 71n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor


(Homo sapiens (Human))
BDBM450349
PNG
(US10676431, Example 112)
Show SMILES CP(C)(=O)c1ccccc1-c1ccc(N2[C@H](CO)C[C@@H](NC(=O)Nc3ccc(Cl)cc3F)C2=O)c(F)c1F
Show InChI InChI=1S/C26H24ClF3N3O4P/c1-38(2,37)22-6-4-3-5-16(22)17-8-10-21(24(30)23(17)29)33-15(13-34)12-20(25(33)35)32-26(36)31-19-9-7-14(27)11-18(19)28/h3-11,15,20,34H,12-13H2,1-2H3,(H2,31,32,36)/t15-,20+/m0/s1
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n/an/an/an/a 390n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor


(Homo sapiens (Human))
BDBM450350
PNG
(US10676431, Example 113)
Show SMILES CC1(C)CN(C(=O)[C@@H]1NC(=O)Nc1ccc(Cl)cc1F)c1ccc(c(F)c1F)-c1cccnc1P(C)(C)=O
Show InChI InChI=1S/C26H25ClF3N4O3P/c1-26(2)13-34(24(35)22(26)33-25(36)32-18-9-7-14(27)12-17(18)28)19-10-8-15(20(29)21(19)30)16-6-5-11-31-23(16)38(3,4)37/h5-12,22H,13H2,1-4H3,(H2,32,33,36)/t22-/m0/s1
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n/an/an/an/a 590n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450354
PNG
(US10676431, Example 117)
Show SMILES CP(C)(=O)c1ccccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3ccc(Cl)cc3F)C2=O)c(C2CC2)c1F
Show InChI InChI=1S/C28H27ClF2N3O3P/c1-38(2,37)24-6-4-3-5-18(24)19-10-12-23(25(26(19)31)16-7-8-16)34-14-13-22(27(34)35)33-28(36)32-21-11-9-17(29)15-20(21)30/h3-6,9-12,15-16,22H,7-8,13-14H2,1-2H3,(H2,32,33,36)/t22-/m1/s1
PDB

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n/an/an/an/a 13n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450357
PNG
(US10676431, Example 120 | US10676431, Example 128)
Show SMILES CC1C[C@@H](NC(=O)Nc2ccc(cc2F)C(F)(F)F)C(=O)N1c1ccc(c(F)c1F)-c1cccnc1P(C)(C)=O
Show InChI InChI=1S/C26H23F6N4O3P/c1-13-11-19(35-25(38)34-18-8-6-14(12-17(18)27)26(30,31)32)24(37)36(13)20-9-7-15(21(28)22(20)29)16-5-4-10-33-23(16)40(2,3)39/h4-10,12-13,19H,11H2,1-3H3,(H2,34,35,38)/t13?,19-/m1/s1
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n/an/an/an/a 0.780n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450358
PNG
(US10676431, Example 121 | US10676431, Example 122)
Show SMILES CC1C[C@@H](NC(=O)Nc2ccc(Cl)cc2F)C(=O)N1c1ccc(c(F)c1F)-c1cccnc1P(C)(C)=O
Show InChI InChI=1S/C25H23ClF3N4O3P/c1-13-11-19(32-25(35)31-18-8-6-14(26)12-17(18)27)24(34)33(13)20-9-7-15(21(28)22(20)29)16-5-4-10-30-23(16)37(2,3)36/h4-10,12-13,19H,11H2,1-3H3,(H2,31,32,35)/t13?,19-/m1/s1
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n/an/an/an/a 0.810n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450362
PNG
(US10676431, Example 125 | US10676431, Example 126 ...)
Show SMILES CP(C)(=O)c1ccccc1-c1ccc(N2CC(CO)[C@@H](NC(=O)Nc3ccc(Cl)cc3F)C2=O)c(F)c1F
Show InChI InChI=1S/C26H24ClF3N3O4P/c1-38(2,37)21-6-4-3-5-16(21)17-8-10-20(23(30)22(17)29)33-12-14(13-34)24(25(33)35)32-26(36)31-19-9-7-15(27)11-18(19)28/h3-11,14,24,34H,12-13H2,1-2H3,(H2,31,32,36)/t14?,24-/m1/s1
PDB

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n/an/an/an/a 0.990n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor


(Homo sapiens (Human))
BDBM450369
PNG
(US10676431, Example 132)
Show SMILES CP(C)(=O)c1ccccc1-c1ccc(N2CC3(CC3)[C@@H](NC(=O)Nc3ccc(Cl)cc3F)C2=O)c(F)c1F
Show InChI InChI=1S/C27H24ClF3N3O3P/c1-38(2,37)21-6-4-3-5-16(21)17-8-10-20(23(31)22(17)30)34-14-27(11-12-27)24(25(34)35)33-26(36)32-19-9-7-15(28)13-18(19)29/h3-10,13,24H,11-12,14H2,1-2H3,(H2,32,33,36)/t24-/m0/s1
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n/an/an/an/a 28n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450371
PNG
(US10676431, Example 134)
Show SMILES CP(C)(=O)c1ccccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3cccc(Cl)c3)C2=O)c(F)c1F
Show InChI InChI=1S/C25H23ClF2N3O3P/c1-35(2,34)21-9-4-3-8-17(21)18-10-11-20(23(28)22(18)27)31-13-12-19(24(31)32)30-25(33)29-16-7-5-6-15(26)14-16/h3-11,14,19H,12-13H2,1-2H3,(H2,29,30,33)/t19-/m1/s1
PDB

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n/an/an/an/a 2.5n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450255
PNG
(US10676431, Example 19)
Show SMILES Fc1ncccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3ccc(Cl)cc3)C2=O)c(F)c1F
Show InChI InChI=1S/C22H16ClF3N4O2/c23-12-3-5-13(6-4-12)28-22(32)29-16-9-11-30(21(16)31)17-8-7-14(18(24)19(17)25)15-2-1-10-27-20(15)26/h1-8,10,16H,9,11H2,(H2,28,29,32)/t16-/m1/s1
PDB

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n/an/an/an/a 22n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450260
PNG
(US10676431, Example 23)
Show SMILES CS(=O)(=O)Nc1ncccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3ccc(Cl)cc3F)C2=O)c(F)c1F
Show InChI InChI=1S/C23H19ClF3N5O4S/c1-37(35,36)31-21-14(3-2-9-28-21)13-5-7-18(20(27)19(13)26)32-10-8-17(22(32)33)30-23(34)29-16-6-4-12(24)11-15(16)25/h2-7,9,11,17H,8,10H2,1H3,(H,28,31)(H2,29,30,34)/t17-/m1/s1
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n/an/an/an/a 8.20n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor


(Homo sapiens (Human))
BDBM450260
PNG
(US10676431, Example 23)
Show SMILES CS(=O)(=O)Nc1ncccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3ccc(Cl)cc3F)C2=O)c(F)c1F
Show InChI InChI=1S/C23H19ClF3N5O4S/c1-37(35,36)31-21-14(3-2-9-28-21)13-5-7-18(20(27)19(13)26)32-10-8-17(22(32)33)30-23(34)29-16-6-4-12(24)11-15(16)25/h2-7,9,11,17H,8,10H2,1H3,(H,28,31)(H2,29,30,34)/t17-/m1/s1
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n/an/an/an/a 700n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450262
PNG
(US10676431, Example 25)
Show SMILES CP(C)(=O)c1ccccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3ccc(Cl)cc3F)C2=O)c(F)c1F
Show InChI InChI=1S/C25H22ClF3N3O3P/c1-36(2,35)21-6-4-3-5-15(21)16-8-10-20(23(29)22(16)28)32-12-11-19(24(32)33)31-25(34)30-18-9-7-14(26)13-17(18)27/h3-10,13,19H,11-12H2,1-2H3,(H2,30,31,34)/t19-/m1/s1
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n/an/an/an/a 0.530n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450265
PNG
(US10676431, Example 28)
Show SMILES Cn1ccc(n1)-c1ccc(N2CC[C@@H](NC(=O)Nc3ccc(Cl)cc3F)C2=O)c(F)c1F
Show InChI InChI=1S/C21H17ClF3N5O2/c1-29-8-6-14(28-29)12-3-5-17(19(25)18(12)24)30-9-7-16(20(30)31)27-21(32)26-15-4-2-11(22)10-13(15)23/h2-6,8,10,16H,7,9H2,1H3,(H2,26,27,32)/t16-/m1/s1
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n/an/an/an/a 9.80n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450269
PNG
(US10676431, Example 32)
Show SMILES CS(=O)(=O)Nc1ccccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3ccc(Cl)cc3F)C2=O)c(F)c1
Show InChI InChI=1S/C24H21ClF2N4O4S/c1-36(34,35)30-19-5-3-2-4-16(19)14-6-9-22(18(27)12-14)31-11-10-21(23(31)32)29-24(33)28-20-8-7-15(25)13-17(20)26/h2-9,12-13,21,30H,10-11H2,1H3,(H2,28,29,33)/t21-/m1/s1
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n/an/an/an/a 0.910n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450271
PNG
(US10676431, Example 34)
Show SMILES COc1c(F)c(ccc1-c1ccccc1NS(C)(=O)=O)N1CC[C@@H](NC(=O)Nc2ccc(Cl)cc2F)C1=O
Show InChI InChI=1S/C25H23ClF2N4O5S/c1-37-23-16(15-5-3-4-6-18(15)31-38(2,35)36)8-10-21(22(23)28)32-12-11-20(24(32)33)30-25(34)29-19-9-7-14(26)13-17(19)27/h3-10,13,20,31H,11-12H2,1-2H3,(H2,29,30,34)/t20-/m1/s1
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n/an/an/an/a 4.10n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor


(Homo sapiens (Human))
BDBM450278
PNG
(US10676431, Example 41)
Show SMILES OCc1ccccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3ccc(cc3)C(F)(F)F)C2=O)c(F)c1F
Show InChI InChI=1S/C25H20F5N3O3/c26-21-18(17-4-2-1-3-14(17)13-34)9-10-20(22(21)27)33-12-11-19(23(33)35)32-24(36)31-16-7-5-15(6-8-16)25(28,29)30/h1-10,19,34H,11-13H2,(H2,31,32,36)/t19-/m1/s1
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n/an/an/an/a 500n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor


(Homo sapiens (Human))
BDBM450284
PNG
(US10676431, Example 47)
Show SMILES CC(C)c1cc(ccc1N1CC[C@@H](NC(=O)Nc2ccc(Cl)cc2F)C1=O)-c1cccnc1NS(C)(=O)=O
Show InChI InChI=1S/C26H27ClFN5O4S/c1-15(2)19-13-16(18-5-4-11-29-24(18)32-38(3,36)37)6-9-23(19)33-12-10-22(25(33)34)31-26(35)30-21-8-7-17(27)14-20(21)28/h4-9,11,13-15,22H,10,12H2,1-3H3,(H,29,32)(H2,30,31,35)/t22-/m1/s1
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n/an/an/an/a 64n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450289
PNG
(US10676431, Example 52)
Show SMILES CS(=O)(=O)c1ccccc1-c1cc(F)c(N2CC[C@@H](NC(=O)Nc3ccc(Cl)cc3F)C2=O)c(F)c1
Show InChI InChI=1S/C24H19ClF3N3O4S/c1-36(34,35)21-5-3-2-4-15(21)13-10-17(27)22(18(28)11-13)31-9-8-20(23(31)32)30-24(33)29-19-7-6-14(25)12-16(19)26/h2-7,10-12,20H,8-9H2,1H3,(H2,29,30,33)/t20-/m1/s1
PDB

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n/an/an/an/a 10n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor


(Homo sapiens (Human))
BDBM450289
PNG
(US10676431, Example 52)
Show SMILES CS(=O)(=O)c1ccccc1-c1cc(F)c(N2CC[C@@H](NC(=O)Nc3ccc(Cl)cc3F)C2=O)c(F)c1
Show InChI InChI=1S/C24H19ClF3N3O4S/c1-36(34,35)21-5-3-2-4-15(21)13-10-17(27)22(18(28)11-13)31-9-8-20(23(31)32)30-24(33)29-19-7-6-14(25)12-16(19)26/h2-7,10-12,20H,8-9H2,1H3,(H2,29,30,33)/t20-/m1/s1
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n/an/an/an/a 1.10E+3n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor


(Homo sapiens (Human))
BDBM450290
PNG
(US10676431, Example 53)
Show SMILES CP(C)(=O)c1ccccc1-c1cc(F)c(N2CC[C@@H](NC(=O)Nc3ccc(Cl)cc3F)C2=O)c(F)c1
Show InChI InChI=1S/C25H22ClF3N3O3P/c1-36(2,35)22-6-4-3-5-16(22)14-11-18(28)23(19(29)12-14)32-10-9-21(24(32)33)31-25(34)30-20-8-7-15(26)13-17(20)27/h3-8,11-13,21H,9-10H2,1-2H3,(H2,30,31,34)/t21-/m1/s1
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n/an/an/an/a 2.70E+3n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450300
PNG
(US10676431, Example 63)
Show SMILES CP(C)(=O)c1ccccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3cnc(Cl)cn3)C2=O)c(F)c1F
Show InChI InChI=1S/C23H21ClF2N5O3P/c1-35(2,34)17-6-4-3-5-13(17)14-7-8-16(21(26)20(14)25)31-10-9-15(22(31)32)29-23(33)30-19-12-27-18(24)11-28-19/h3-8,11-12,15H,9-10H2,1-2H3,(H2,28,29,30,33)/t15-/m1/s1
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n/an/an/an/a 5.67n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%