Affinity Data by Patent

Patent code US10676458

Found 17 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM450607 ((2S,3R)-3-(2-(1-(2,5-bis(Trifluoromethyl)benzyl)pi...) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	UniChem	US Patent	n/a	n/a	n/a	n/a	611	n/a	n/a	n/a	n/a
Merch Sharp & Dohne Corp. Rahway US Patent					Assay Description The assay was performed in 384-well format. HEK cells stably expressing human GPR40 were plated at 7500 cells per well in growth medium (DMEM/10% fet...				US Patent US10676458 (2020)
Merch Sharp & Dohne Corp. Rahway US Patent					More data for this Ligand-Target Pair
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM450622 (Sodium (2S,3R)-3-cyclopropyl-3-((R or S)-3-(2̸...) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	UniChem	US Patent	n/a	n/a	n/a	n/a	0.800	n/a	n/a	n/a	n/a
Merch Sharp & Dohne Corp. Rahway US Patent					Assay Description The assay was performed in 384-well format. HEK cells stably expressing human GPR40 were plated at 7500 cells per well in growth medium (DMEM/10% fet...				US Patent US10676458 (2020)
Merch Sharp & Dohne Corp. Rahway US Patent					More data for this Ligand-Target Pair
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM450616 (Sodium (2S,3R)-3-cyclopropyl-3-((R or S)-2-(2̸...) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	UniChem	US Patent	n/a	n/a	n/a	n/a	0.200	n/a	n/a	n/a	n/a
Merch Sharp & Dohne Corp. Rahway US Patent					Assay Description The assay was performed in 384-well format. HEK cells stably expressing human GPR40 were plated at 7500 cells per well in growth medium (DMEM/10% fet...				US Patent US10676458 (2020)
Merch Sharp & Dohne Corp. Rahway US Patent					More data for this Ligand-Target Pair
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM450608 (Sodium (2S,3S)-3-((R or S)-3-(1-(2,5-Bis(trifluoro...) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	UniChem	US Patent	n/a	n/a	n/a	n/a	388	n/a	n/a	n/a	n/a
Merch Sharp & Dohne Corp. Rahway US Patent					Assay Description The assay was performed in 384-well format. HEK cells stably expressing human GPR40 were plated at 7500 cells per well in growth medium (DMEM/10% fet...				US Patent US10676458 (2020)
Merch Sharp & Dohne Corp. Rahway US Patent					More data for this Ligand-Target Pair
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM450610 (Sodium (2S,3S)-3-((R or S)-3-(1-(2,5-bis(trifluoro...) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	UniChem	US Patent	n/a	n/a	n/a	n/a	4.70E+3	n/a	n/a	n/a	n/a
Merch Sharp & Dohne Corp. Rahway US Patent					Assay Description The assay was performed in 384-well format. HEK cells stably expressing human GPR40 were plated at 7500 cells per well in growth medium (DMEM/10% fet...				US Patent US10676458 (2020)
Merch Sharp & Dohne Corp. Rahway US Patent					More data for this Ligand-Target Pair
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM450612 (Sodium (2S,3R)-3-((R or S)-2-(1-(2,5-bis(trifluoro...) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	UniChem	US Patent	n/a	n/a	n/a	n/a	99	n/a	n/a	n/a	n/a
Merch Sharp & Dohne Corp. Rahway US Patent					Assay Description The assay was performed in 384-well format. HEK cells stably expressing human GPR40 were plated at 7500 cells per well in growth medium (DMEM/10% fet...				US Patent US10676458 (2020)
Merch Sharp & Dohne Corp. Rahway US Patent					More data for this Ligand-Target Pair
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM450618 ((2S,3R)-3-cyclopropyl-3-((R or S)-2-(2′-fluo...) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	UniChem	US Patent	n/a	n/a	n/a	n/a	12	n/a	n/a	n/a	n/a
Merch Sharp & Dohne Corp. Rahway US Patent					Assay Description The assay was performed in 384-well format. HEK cells stably expressing human GPR40 were plated at 7500 cells per well in growth medium (DMEM/10% fet...				US Patent US10676458 (2020)
Merch Sharp & Dohne Corp. Rahway US Patent					More data for this Ligand-Target Pair
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM450616 (Sodium (2S,3R)-3-cyclopropyl-3-((R or S)-2-(2̸...) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	UniChem	US Patent	n/a	n/a	n/a	n/a	0.790	n/a	n/a	n/a	n/a
Merch Sharp & Dohne Corp. Rahway US Patent					Assay Description The assay was performed in 384-well format. HEK cells stably expressing human GPR40 were plated at 7500 cells per well in growth medium (DMEM/10% fet...				US Patent US10676458 (2020)
Merch Sharp & Dohne Corp. Rahway US Patent					More data for this Ligand-Target Pair
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM450618 ((2S,3R)-3-cyclopropyl-3-((R or S)-2-(2′-fluo...) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	UniChem	US Patent	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
Merch Sharp & Dohne Corp. Rahway US Patent					Assay Description The assay was performed in 384-well format. HEK cells stably expressing human GPR40 were plated at 7500 cells per well in growth medium (DMEM/10% fet...				US Patent US10676458 (2020)
Merch Sharp & Dohne Corp. Rahway US Patent					More data for this Ligand-Target Pair
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM450620 (Sodium (2S,3R)-3-cyclopropyl-3-((R or S)-3-(2̸...) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	UniChem	US Patent	n/a	n/a	n/a	n/a	0.800	n/a	n/a	n/a	n/a
Merch Sharp & Dohne Corp. Rahway US Patent					Assay Description The assay was performed in 384-well format. HEK cells stably expressing human GPR40 were plated at 7500 cells per well in growth medium (DMEM/10% fet...				US Patent US10676458 (2020)
Merch Sharp & Dohne Corp. Rahway US Patent					More data for this Ligand-Target Pair
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM450615 ((2S,3R)-3-((S or R)-2-(1- (2,5-bis(trifluoromethyl...) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	UniChem	US Patent	n/a	n/a	n/a	n/a	289	n/a	n/a	n/a	n/a
Merch Sharp & Dohne Corp. Rahway US Patent					Assay Description The assay was performed in 384-well format. HEK cells stably expressing human GPR40 were plated at 7500 cells per well in growth medium (DMEM/10% fet...				US Patent US10676458 (2020)
Merch Sharp & Dohne Corp. Rahway US Patent					More data for this Ligand-Target Pair
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM450620 (Sodium (2S,3R)-3-cyclopropyl-3-((R or S)-3-(2̸...) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	UniChem	US Patent	n/a	n/a	n/a	n/a	10	n/a	n/a	n/a	n/a
Merch Sharp & Dohne Corp. Rahway US Patent					Assay Description The assay was performed in 384-well format. HEK cells stably expressing human GPR40 were plated at 7500 cells per well in growth medium (DMEM/10% fet...				US Patent US10676458 (2020)
Merch Sharp & Dohne Corp. Rahway US Patent					More data for this Ligand-Target Pair
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM450610 (Sodium (2S,3S)-3-((R or S)-3-(1-(2,5-bis(trifluoro...) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	UniChem	US Patent	n/a	n/a	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a
Merch Sharp & Dohne Corp. Rahway US Patent					Assay Description The assay was performed in 384-well format. HEK cells stably expressing human GPR40 were plated at 7500 cells per well in growth medium (DMEM/10% fet...				US Patent US10676458 (2020)
Merch Sharp & Dohne Corp. Rahway US Patent					More data for this Ligand-Target Pair
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM450612 (Sodium (2S,3R)-3-((R or S)-2-(1-(2,5-bis(trifluoro...) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	UniChem	US Patent	n/a	n/a	n/a	n/a	35	n/a	n/a	n/a	n/a
Merch Sharp & Dohne Corp. Rahway US Patent					Assay Description The assay was performed in 384-well format. HEK cells stably expressing human GPR40 were plated at 7500 cells per well in growth medium (DMEM/10% fet...				US Patent US10676458 (2020)
Merch Sharp & Dohne Corp. Rahway US Patent					More data for this Ligand-Target Pair
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM450622 (Sodium (2S,3R)-3-cyclopropyl-3-((R or S)-3-(2̸...) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	UniChem	US Patent	n/a	n/a	n/a	n/a	12	n/a	n/a	n/a	n/a
Merch Sharp & Dohne Corp. Rahway US Patent					Assay Description The assay was performed in 384-well format. HEK cells stably expressing human GPR40 were plated at 7500 cells per well in growth medium (DMEM/10% fet...				US Patent US10676458 (2020)
Merch Sharp & Dohne Corp. Rahway US Patent					More data for this Ligand-Target Pair
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM450609 (Sodium (2S,3R)-methyl 3- ((S or R)-3-(1-(2,5- bis(...) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	UniChem	US Patent	n/a	n/a	n/a	n/a	642	n/a	n/a	n/a	n/a
Merch Sharp & Dohne Corp. Rahway US Patent					Assay Description The assay was performed in 384-well format. HEK cells stably expressing human GPR40 were plated at 7500 cells per well in growth medium (DMEM/10% fet...				US Patent US10676458 (2020)
Merch Sharp & Dohne Corp. Rahway US Patent					More data for this Ligand-Target Pair
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM450614 ((2S,3R)-3-((R or S)-2-(1-(2,5-bis(trifluoromethyl)...) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	UniChem	US Patent	n/a	n/a	n/a	n/a	439	n/a	n/a	n/a	n/a
Merch Sharp & Dohne Corp. Rahway US Patent					Assay Description The assay was performed in 384-well format. HEK cells stably expressing human GPR40 were plated at 7500 cells per well in growth medium (DMEM/10% fet...				US Patent US10676458 (2020)
Merch Sharp & Dohne Corp. Rahway US Patent					More data for this Ligand-Target Pair

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* indicates data uncertainty>20%