BindingDB logo
myBDB logout

Patent code US10683279

Compile Data Set for Download or QSAR
Found 71 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445429
PNG
(US10683279, Example 26a)
Show SMILES Cc1cc(F)c(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc(n1)-c1nnnn1C(CO)CO
Show InChI InChI=1S/C23H23FN8O3/c1-13-7-17(24)16(8-20(13)31-9-19(25-12-31)14-5-6-14)23(35)27-21-4-2-3-18(26-21)22-28-29-30-32(22)15(10-33)11-34/h2-4,7-9,12,14-15,33-34H,5-6,10-11H2,1H3,(H,26,27,35)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445404
PNG
(5-(4-cyclopropyl-1H-imidazol-1-yl)-2-fluoro-N-(6-(...)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc(c(C)cc2F)-n2cnc(c2)C2CC2)n1
Show InChI InChI=1S/C23H23FN8O/c1-13(2)32-22(28-29-30-32)18-5-4-6-21(26-18)27-23(33)16-10-20(14(3)9-17(16)24)31-11-19(25-12-31)15-7-8-15/h4-6,9-13,15H,7-8H2,1-3H3,(H,26,27,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445436
PNG
(US10683279, Example 33a)
Show SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc(c(CO)cc2F)-n2cnc(c2)C2CC2)n1
Show InChI InChI=1S/C23H23FN8O3/c1-13(10-33)32-22(28-29-30-32)18-3-2-4-21(26-18)27-23(35)16-8-20(15(11-34)7-17(16)24)31-9-19(25-12-31)14-5-6-14/h2-4,7-9,12-14,33-34H,5-6,10-11H2,1H3,(H,26,27,35)/t13-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445440
PNG
(US10683279, Example 37a)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc(c(cc2F)C(F)(F)F)-n2cnc(c2)C2CC2)n1
Show InChI InChI=1S/C23H20F4N8O/c1-12(2)35-21(31-32-33-35)17-4-3-5-20(29-17)30-22(36)14-8-19(15(9-16(14)24)23(25,26)27)34-10-18(28-11-34)13-6-7-13/h3-5,8-13H,6-7H2,1-2H3,(H,29,30,36)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445449
PNG
(US10683279, Example 46a)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc(c(cn2)N2CCOCC2)-n2cnc(c2)C2CC2)n1
Show InChI InChI=1S/C25H28N10O2/c1-16(2)35-24(30-31-32-35)18-4-3-5-23(28-18)29-25(36)19-12-21(34-14-20(27-15-34)17-6-7-17)22(13-26-19)33-8-10-37-11-9-33/h3-5,12-17H,6-11H2,1-2H3,(H,28,29,36)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445406
PNG
(5-(4-cyclopropyl-1H-imidazol-1-yl)-2-fluoro-N-(6-(...)
Show SMILES Cc1cc(F)c(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc(n1)-c1nnnn1C1(C)CC1
Show InChI InChI=1S/C24H23FN8O/c1-14-10-17(25)16(11-20(14)32-12-19(26-13-32)15-6-7-15)23(34)28-21-5-3-4-18(27-21)22-29-30-31-33(22)24(2)8-9-24/h3-5,10-13,15H,6-9H2,1-2H3,(H,27,28,34)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445413
PNG
(US10683279, Example 10a)
Show SMILES Cc1cc(F)c(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc(n1)-c1nnnn1C1CCC1
Show InChI InChI=1S/C24H23FN8O/c1-14-10-18(25)17(11-21(14)32-12-20(26-13-32)15-8-9-15)24(34)28-22-7-3-6-19(27-22)23-29-30-31-33(23)16-4-2-5-16/h3,6-7,10-13,15-16H,2,4-5,8-9H2,1H3,(H,27,28,34)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445416
PNG
(US10683279, Example 13a)
Show SMILES Cc1cc(F)c(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc(n1)-c1nnnn1CC(C)(C)C
Show InChI InChI=1S/C25H27FN8O/c1-15-10-18(26)17(11-21(15)33-12-20(27-14-33)16-8-9-16)24(35)29-22-7-5-6-19(28-22)23-30-31-32-34(23)13-25(2,3)4/h5-7,10-12,14,16H,8-9,13H2,1-4H3,(H,28,29,35)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445420
PNG
(US10683279, Example 17a)
Show SMILES Cc1cc(F)c(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc(n1)-c1nnnn1[C@@H]1CCOC1
Show InChI InChI=1S/C24H23FN8O2/c1-14-9-18(25)17(10-21(14)32-11-20(26-13-32)15-5-6-15)24(34)28-22-4-2-3-19(27-22)23-29-30-31-33(23)16-7-8-35-12-16/h2-4,9-11,13,15-16H,5-8,12H2,1H3,(H,27,28,34)/t16-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445421
PNG
(US10683279, Example 18a)
Show SMILES Cc1cc(F)c(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc(n1)-c1nnnn1[C@H]1CCOC1
Show InChI InChI=1S/C24H23FN8O2/c1-14-9-18(25)17(10-21(14)32-11-20(26-13-32)15-5-6-15)24(34)28-22-4-2-3-19(27-22)23-29-30-31-33(23)16-7-8-35-12-16/h2-4,9-11,13,15-16H,5-8,12H2,1H3,(H,27,28,34)/t16-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445426
PNG
(US10683279, Example 23a)
Show SMILES C[C@H](CCOC(C)=O)n1nnnc1-c1cccc(NC(=O)c2cc(c(C)cc2F)-n2cnc(c2)C2CC2)n1
Show InChI InChI=1S/C26H27FN8O3/c1-15-11-20(27)19(12-23(15)34-13-22(28-14-34)18-7-8-18)26(37)30-24-6-4-5-21(29-24)25-31-32-33-35(25)16(2)9-10-38-17(3)36/h4-6,11-14,16,18H,7-10H2,1-3H3,(H,29,30,37)/t16-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445460
PNG
(US10683279, Example 57a)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc(c(cn2)C(F)(F)F)-n2cnc(c2)C2CC2)n1
Show InChI InChI=1S/C22H20F3N9O/c1-12(2)34-20(30-31-32-34)15-4-3-5-19(28-15)29-21(35)16-8-18(14(9-26-16)22(23,24)25)33-10-17(27-11-33)13-6-7-13/h3-5,8-13H,6-7H2,1-2H3,(H,28,29,35)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445414
PNG
(US10683279, Example 11a)
Show SMILES Cc1cc(F)c(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc(n1)-c1nnnn1C1CC(F)(F)C1
Show InChI InChI=1S/C24H21F3N8O/c1-13-7-17(25)16(8-20(13)34-11-19(28-12-34)14-5-6-14)23(36)30-21-4-2-3-18(29-21)22-31-32-33-35(22)15-9-24(26,27)10-15/h2-4,7-8,11-12,14-15H,5-6,9-10H2,1H3,(H,29,30,36)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445417
PNG
(US10683279, Example 14a)
Show SMILES C[C@H](CF)n1nnnc1-c1cccc(NC(=O)c2cc(c(C)cc2F)-n2cnc(c2)C2CC2)n1
Show InChI InChI=1S/C23H22F2N8O/c1-13-8-17(25)16(9-20(13)32-11-19(26-12-32)15-6-7-15)23(34)28-21-5-3-4-18(27-21)22-29-30-31-33(22)14(2)10-24/h3-5,8-9,11-12,14-15H,6-7,10H2,1-2H3,(H,27,28,34)/t14-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445418
PNG
(US10683279, Example 15a)
Show SMILES C[C@@H](CF)n1nnnc1-c1cccc(NC(=O)c2cc(c(C)cc2F)-n2cnc(c2)C2CC2)n1
Show InChI InChI=1S/C23H22F2N8O/c1-13-8-17(25)16(9-20(13)32-11-19(26-12-32)15-6-7-15)23(34)28-21-5-3-4-18(27-21)22-29-30-31-33(22)14(2)10-24/h3-5,8-9,11-12,14-15H,6-7,10H2,1-2H3,(H,27,28,34)/t14-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445424
PNG
(US10683279, Example 21a)
Show SMILES Cc1cc(F)c(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc(n1)-c1nnnn1[C@@H]1C[C@H](O)C1
Show InChI InChI=1S/C24H23FN8O2/c1-13-7-18(25)17(10-21(13)32-11-20(26-12-32)14-5-6-14)24(35)28-22-4-2-3-19(27-22)23-29-30-31-33(23)15-8-16(34)9-15/h2-4,7,10-12,14-16,34H,5-6,8-9H2,1H3,(H,27,28,35)/t15-,16+
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445432
PNG
(US10683279, Example 29a)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc(c(C)cc2F)-n2cnc(c2)C(C)(C)C)n1
Show InChI InChI=1S/C24H27FN8O/c1-14(2)33-22(29-30-31-33)18-8-7-9-21(27-18)28-23(34)16-11-19(15(3)10-17(16)25)32-12-20(26-13-32)24(4,5)6/h7-14H,1-6H3,(H,27,28,34)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445435
PNG
(US10683279, Example 32a)
Show SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc(c(cc2F)C(F)F)-n2cnc(c2)C2CC2)n1
Show InChI InChI=1S/C23H21F3N8O2/c1-12(10-35)34-22(30-31-32-34)17-3-2-4-20(28-17)29-23(36)14-8-19(15(21(25)26)7-16(14)24)33-9-18(27-11-33)13-5-6-13/h2-4,7-9,11-13,21,35H,5-6,10H2,1H3,(H,28,29,36)/t12-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445441
PNG
(US10683279, Example 38a)
Show SMILES CC(C)n1nnnc1-c1nc(NC(=O)c2cc(c(F)cn2)-n2cnc(c2)C2CC2)cs1
Show InChI InChI=1S/C19H18FN9OS/c1-10(2)29-17(25-26-27-29)19-24-16(8-31-19)23-18(30)13-5-15(12(20)6-21-13)28-7-14(22-9-28)11-3-4-11/h5-11H,3-4H2,1-2H3,(H,23,30)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445452
PNG
(US10683279, Example 49a)
Show SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc(c(C)cn2)-n2cnc(c2)C2CC2)n1
Show InChI InChI=1S/C22H23N9O2/c1-13-9-23-17(8-19(13)30-10-18(24-12-30)15-6-7-15)22(33)26-20-5-3-4-16(25-20)21-27-28-29-31(21)14(2)11-32/h3-5,8-10,12,14-15,32H,6-7,11H2,1-2H3,(H,25,26,33)/t14-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445411
PNG
(US10683279, Example 8a)
Show SMILES Cc1cc(F)c(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc(n1)-c1nnnn1C1CCCC1
Show InChI InChI=1S/C25H25FN8O/c1-15-11-19(26)18(12-22(15)33-13-21(27-14-33)16-9-10-16)25(35)29-23-8-4-7-20(28-23)24-30-31-32-34(24)17-5-2-3-6-17/h4,7-8,11-14,16-17H,2-3,5-6,9-10H2,1H3,(H,28,29,35)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445445
PNG
(US10683279, Example 42a)
Show SMILES CC(C)n1nnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CCCC2)-n2cnc(c2)C2CC2)cs1
Show InChI InChI=1S/C23H26N10OS/c1-14(2)33-21(28-29-30-33)23-27-20(12-35-23)26-22(34)16-9-18(19(10-24-16)31-7-3-4-8-31)32-11-17(25-13-32)15-5-6-15/h9-15H,3-8H2,1-2H3,(H,26,34)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445446
PNG
(US10683279, Example 43a)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc(c(cn2)N2CCCC2)-n2cnc(c2)C2CC2)n1
Show InChI InChI=1S/C25H28N10O/c1-16(2)35-24(30-31-32-35)18-6-5-7-23(28-18)29-25(36)19-12-21(22(13-26-19)33-10-3-4-11-33)34-14-20(27-15-34)17-8-9-17/h5-7,12-17H,3-4,8-11H2,1-2H3,(H,28,29,36)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445453
PNG
(US10683279, Example 50a | US10683279, Example 52a)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc(c(C)cn2)-n2cnc(c2)C(C)(C)C)n1
Show InChI InChI=1S/C23H27N9O/c1-14(2)32-21(28-29-30-32)16-8-7-9-20(26-16)27-22(33)17-10-18(15(3)11-24-17)31-12-19(25-13-31)23(4,5)6/h7-14H,1-6H3,(H,26,27,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445453
PNG
(US10683279, Example 50a | US10683279, Example 52a)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc(c(C)cn2)-n2cnc(c2)C(C)(C)C)n1
Show InChI InChI=1S/C23H27N9O/c1-14(2)32-21(28-29-30-32)16-8-7-9-20(26-16)27-22(33)17-10-18(15(3)11-24-17)31-12-19(25-13-31)23(4,5)6/h7-14H,1-6H3,(H,26,27,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445459
PNG
(US10683279, Example 56a)
Show SMILES CC(C)n1nnnc1-c1nc(NC(=O)c2cc(c(cn2)C(F)F)-n2cnc(c2)C2CC2)cs1
Show InChI InChI=1S/C20H19F2N9OS/c1-10(2)31-18(27-28-29-31)20-26-16(8-33-20)25-19(32)13-5-15(12(6-23-13)17(21)22)30-7-14(24-9-30)11-3-4-11/h5-11,17H,3-4H2,1-2H3,(H,25,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445405
PNG
(5-(4-cyclopropyl-1H-imidazol-1-yl)-2-fluoro-N-(6-(...)
Show SMILES Cc1cc(F)c(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc(n1)-c1nnnn1C1CC1
Show InChI InChI=1S/C23H21FN8O/c1-13-9-17(24)16(10-20(13)31-11-19(25-12-31)14-5-6-14)23(33)27-21-4-2-3-18(26-21)22-28-29-30-32(22)15-7-8-15/h2-4,9-12,14-15H,5-8H2,1H3,(H,26,27,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445415
PNG
(US10683279, Example 12a)
Show SMILES Cc1cc(F)c(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc(n1)-c1nnnn1CC(F)F
Show InChI InChI=1S/C22H19F3N8O/c1-12-7-15(23)14(8-18(12)32-9-17(26-11-32)13-5-6-13)22(34)28-20-4-2-3-16(27-20)21-29-30-31-33(21)10-19(24)25/h2-4,7-9,11,13,19H,5-6,10H2,1H3,(H,27,28,34)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445425
PNG
(US10683279, Example 22a)
Show SMILES C[C@H](CCO)n1nnnc1-c1cccc(NC(=O)c2cc(c(C)cc2F)-n2cnc(c2)C2CC2)n1
Show InChI InChI=1S/C24H25FN8O2/c1-14-10-18(25)17(11-21(14)32-12-20(26-13-32)16-6-7-16)24(35)28-22-5-3-4-19(27-22)23-29-30-31-33(23)15(2)8-9-34/h3-5,10-13,15-16,34H,6-9H2,1-2H3,(H,27,28,35)/t15-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445431
PNG
(US10683279, Example 28a)
Show SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc(c(C)cc2F)-n2cnc(c2)C(F)(F)F)n1
Show InChI InChI=1S/C21H18F4N8O2/c1-11-6-14(22)13(7-16(11)32-8-17(26-10-32)21(23,24)25)20(35)28-18-5-3-4-15(27-18)19-29-30-31-33(19)12(2)9-34/h3-8,10,12,34H,9H2,1-2H3,(H,27,28,35)/t12-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445433
PNG
(US10683279, Example 30a)
Show SMILES C[C@H](COC(C)=O)n1nnnc1-c1cccc(NC(=O)c2cc(c(C)cc2F)-n2cnc(c2)C(C)(C)C)n1
Show InChI InChI=1S/C26H29FN8O3/c1-15-10-19(27)18(11-21(15)34-12-22(28-14-34)26(4,5)6)25(37)30-23-9-7-8-20(29-23)24-31-32-33-35(24)16(2)13-38-17(3)36/h7-12,14,16H,13H2,1-6H3,(H,29,30,37)/t16-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445448
PNG
(US10683279, Example 45a)
Show SMILES CC(C)n1nnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CCOCC2)-n2cnc(c2)C2CC2)cs1
Show InChI InChI=1S/C23H26N10O2S/c1-14(2)33-21(28-29-30-33)23-27-20(12-36-23)26-22(34)16-9-18(32-11-17(25-13-32)15-3-4-15)19(10-24-16)31-5-7-35-8-6-31/h9-15H,3-8H2,1-2H3,(H,26,34)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445464
PNG
(US10683279, Example 61a)
Show SMILES COc1cc(C)c(cc1C(=O)Nc1cccc(n1)-c1nnnn1[C@H](C)CO)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C24H26N8O3/c1-14-9-21(35-3)17(10-20(14)31-11-19(25-13-31)16-7-8-16)24(34)27-22-6-4-5-18(26-22)23-28-29-30-32(23)15(2)12-33/h4-6,9-11,13,15-16,33H,7-8,12H2,1-3H3,(H,26,27,34)/t15-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445407
PNG
((S)-2-(5-(6-(5-(4-cyclopropyl-1H-imidazol-1-yl)-2-...)
Show SMILES CC(COC(C)=O)n1nnnc1-c1cccc(NC(=O)c2cc(c(C)cc2F)-n2cnc(c2)C2CC2)n1
Show InChI InChI=1S/C25H25FN8O3/c1-14-9-19(26)18(10-22(14)33-11-21(27-13-33)17-7-8-17)25(36)29-23-6-4-5-20(28-23)24-30-31-32-34(24)15(2)12-37-16(3)35/h4-6,9-11,13,15,17H,7-8,12H2,1-3H3,(H,28,29,36)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445442
PNG
(US10683279, Example 39a)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc(c(F)cn2)-n2cnc(c2)C2CC2)n1
Show InChI InChI=1S/C21H20FN9O/c1-12(2)31-20(27-28-29-31)15-4-3-5-19(25-15)26-21(32)16-8-18(14(22)9-23-16)30-10-17(24-11-30)13-6-7-13/h3-5,8-13H,6-7H2,1-2H3,(H,25,26,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445447
PNG
(US10683279, Example 44a)
Show SMILES CC(C)n1nnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CCC(C)CC2)-n2cnc(c2)C2CC2)cs1
Show InChI InChI=1S/C25H30N10OS/c1-15(2)35-23(30-31-32-35)25-29-22(13-37-25)28-24(36)18-10-20(34-12-19(27-14-34)17-4-5-17)21(11-26-18)33-8-6-16(3)7-9-33/h10-17H,4-9H2,1-3H3,(H,28,36)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445461
PNG
(US10683279, Example 58a)
Show SMILES CC(CO)n1nnnc1-c1cccc(NC(=O)c2cc(c(cn2)C(F)(F)F)-n2cnc(c2)C2CC2)n1
Show InChI InChI=1S/C22H20F3N9O2/c1-12(10-35)34-20(30-31-32-34)15-3-2-4-19(28-15)29-21(36)16-7-18(14(8-26-16)22(23,24)25)33-9-17(27-11-33)13-5-6-13/h2-4,7-9,11-13,35H,5-6,10H2,1H3,(H,28,29,36)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445463
PNG
(US10683279, Example 60a)
Show SMILES COc1cc(C)c(cc1C(=O)Nc1cccc(n1)-c1nnnn1C(C)C)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C24H26N8O2/c1-14(2)32-23(28-29-30-32)18-6-5-7-22(26-18)27-24(33)17-11-20(15(3)10-21(17)34-4)31-12-19(25-13-31)16-8-9-16/h5-7,10-14,16H,8-9H2,1-4H3,(H,26,27,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445465
PNG
(US10683279, Example 1b | US10683279, Example 1c)
Show SMILES CC(C)c1nnnn1-c1cccc(NC(=O)c2cc(c(C)cc2F)-n2cnc(c2)C2CC2)n1
Show InChI InChI=1S/C23H23FN8O/c1-13(2)22-28-29-30-32(22)21-6-4-5-20(26-21)27-23(33)16-10-19(14(3)9-17(16)24)31-11-18(25-12-31)15-7-8-15/h4-6,9-13,15H,7-8H2,1-3H3,(H,26,27,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445467
PNG
(US10683279, Example 3b)
Show SMILES CC(C)c1nnnn1-c1cccc(NC(=O)c2cc(c(C)cn2)-n2cnc(c2)C2CC2)n1
Show InChI InChI=1S/C22H23N9O/c1-13(2)21-27-28-29-31(21)20-6-4-5-19(25-20)26-22(32)16-9-18(14(3)10-23-16)30-11-17(24-12-30)15-7-8-15/h4-6,9-13,15H,7-8H2,1-3H3,(H,25,26,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445469
PNG
(US10683279, Example 5b)
Show SMILES CC(C)c1nnnn1-c1cccc(NC(=O)c2cc(c(C)cn2)-n2cnc(c2)C(C)(C)C)n1
Show InChI InChI=1S/C23H27N9O/c1-14(2)21-28-29-30-32(21)20-9-7-8-19(26-20)27-22(33)16-10-17(15(3)11-24-16)31-12-18(25-13-31)23(4,5)6/h7-14H,1-6H3,(H,26,27,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445450
PNG
(US10683279, Example 47a)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc(c(cn2)N2CCN(C)CC2)-n2cnc(c2)C2CC2)n1
Show InChI InChI=1S/C26H31N11O/c1-17(2)37-25(31-32-33-37)19-5-4-6-24(29-19)30-26(38)20-13-22(36-15-21(28-16-36)18-7-8-18)23(14-27-20)35-11-9-34(3)10-12-35/h4-6,13-18H,7-12H2,1-3H3,(H,29,30,38)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445454
PNG
(US10683279, Example 51a)
Show SMILES CC[C@@H](C)n1nnnc1-c1cccc(NC(=O)c2cc(c(C)cn2)-n2cnc(c2)C(C)(C)C)n1
Show InChI InChI=1S/C24H29N9O/c1-7-16(3)33-22(29-30-31-33)17-9-8-10-21(27-17)28-23(34)18-11-19(15(2)12-25-18)32-13-20(26-14-32)24(4,5)6/h8-14,16H,7H2,1-6H3,(H,27,28,34)/t16-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445456
PNG
(US10683279, Example 53a)
Show SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc(c(C)cn2)-n2cnc(c2)C(C)(C)C)n1
Show InChI InChI=1S/C23H27N9O2/c1-14-10-24-17(9-18(14)31-11-19(25-13-31)23(3,4)5)22(34)27-20-8-6-7-16(26-20)21-28-29-30-32(21)15(2)12-33/h6-11,13,15,33H,12H2,1-5H3,(H,26,27,34)/t15-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445458
PNG
(US10683279, Example 55a)
Show SMILES CC(CO)n1nnnc1-c1cccc(NC(=O)c2cc(c(cn2)C(F)F)-n2cnc(c2)C2CC2)n1
Show InChI InChI=1S/C22H21F2N9O2/c1-12(10-34)33-21(29-30-31-33)15-3-2-4-19(27-15)28-22(35)16-7-18(14(8-25-16)20(23)24)32-9-17(26-11-32)13-5-6-13/h2-4,7-9,11-13,20,34H,5-6,10H2,1H3,(H,27,28,35)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445462
PNG
(US10683279, Example 59a)
Show SMILES CC(C)n1nnnc1-c1nc(NC(=O)c2cc(c(cn2)C(F)(F)F)-n2cnc(c2)C2CC2)cs1
Show InChI InChI=1S/C20H18F3N9OS/c1-10(2)32-17(28-29-30-32)19-27-16(8-34-19)26-18(33)13-5-15(12(6-24-13)20(21,22)23)31-7-14(25-9-31)11-3-4-11/h5-11H,3-4H2,1-2H3,(H,26,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445470
PNG
(US10683279, Example 6b)
Show SMILES CC(C)c1nnnn1-c1cccc(NC(=O)c2cc(c(C)cc2F)-n2cnc(c2)C(C)(C)C)n1
Show InChI InChI=1S/C24H27FN8O/c1-14(2)22-29-30-31-33(22)21-9-7-8-20(27-21)28-23(34)16-11-18(15(3)10-17(16)25)32-12-19(26-13-32)24(4,5)6/h7-14H,1-6H3,(H,27,28,34)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445407
PNG
((S)-2-(5-(6-(5-(4-cyclopropyl-1H-imidazol-1-yl)-2-...)
Show SMILES CC(COC(C)=O)n1nnnc1-c1cccc(NC(=O)c2cc(c(C)cc2F)-n2cnc(c2)C2CC2)n1
Show InChI InChI=1S/C25H25FN8O3/c1-14-9-19(26)18(10-22(14)33-11-21(27-13-33)17-7-8-17)25(36)29-23-6-4-5-20(28-23)24-30-31-32-34(24)15(2)12-37-16(3)35/h4-6,9-11,13,15,17H,7-8,12H2,1-3H3,(H,28,29,36)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445410
PNG
((R)-5-(4-cyclopropyl-1H-imidazol-1-yl)-2-fluoro-N-...)
Show SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc(c(C)cc2F)-n2cnc(c2)C2CC2)n1
Show InChI InChI=1S/C23H23FN8O2/c1-13-8-17(24)16(9-20(13)31-10-19(25-12-31)15-6-7-15)23(34)27-21-5-3-4-18(26-21)22-28-29-30-32(22)14(2)11-33/h3-5,8-10,12,14-15,33H,6-7,11H2,1-2H3,(H,26,27,34)/t14-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445434
PNG
(US10683279, Example 31a)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc(c(cc2F)C(F)F)-n2cnc(c2)C2CC2)n1
Show InChI InChI=1S/C23H21F3N8O/c1-12(2)34-22(30-31-32-34)17-4-3-5-20(28-17)29-23(35)14-9-19(15(21(25)26)8-16(14)24)33-10-18(27-11-33)13-6-7-13/h3-5,8-13,21H,6-7H2,1-2H3,(H,28,29,35)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445457
PNG
(US10683279, Example 54a)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc(c(cn2)C(F)F)-n2cnc(c2)C2CC2)n1
Show InChI InChI=1S/C22H21F2N9O/c1-12(2)33-21(29-30-31-33)15-4-3-5-19(27-15)28-22(34)16-8-18(14(9-25-16)20(23)24)32-10-17(26-11-32)13-6-7-13/h3-5,8-13,20H,6-7H2,1-2H3,(H,27,28,34)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445443
PNG
(US10683279, Example 40a)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc(c(cn2)N2CCCCC2)-n2cnc(c2)C2CC2)n1
Show InChI InChI=1S/C26H30N10O/c1-17(2)36-25(31-32-33-36)19-7-6-8-24(29-19)30-26(37)20-13-22(35-15-21(28-16-35)18-9-10-18)23(14-27-20)34-11-4-3-5-12-34/h6-8,13-18H,3-5,9-12H2,1-2H3,(H,29,30,37)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 55n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445444
PNG
(US10683279, Example 41a)
Show SMILES CC(C)n1nnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CCCCC2)-n2cnc(c2)C2CC2)cs1
Show InChI InChI=1S/C24H28N10OS/c1-15(2)34-22(29-30-31-34)24-28-21(13-36-24)27-23(35)17-10-19(33-12-18(26-14-33)16-6-7-16)20(11-25-17)32-8-4-3-5-9-32/h10-16H,3-9H2,1-2H3,(H,27,35)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 55n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445430
PNG
(US10683279, Example 27a)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc(c(C)cc2F)-n2cnc(c2)C(F)(F)F)n1
Show InChI InChI=1S/C21H18F4N8O/c1-11(2)33-19(29-30-31-33)15-5-4-6-18(27-15)28-20(34)13-8-16(12(3)7-14(13)22)32-9-17(26-10-32)21(23,24)25/h4-11H,1-3H3,(H,27,28,34)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 55n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445427
PNG
(US10683279, Example 24a)
Show SMILES CCCC(=O)OC[C@@H](C)n1nnnc1-c1cccc(NC(=O)c2cc(c(C)cc2F)-n2cnc(c2)C2CC2)n1
Show InChI InChI=1S/C27H29FN8O3/c1-4-6-25(37)39-14-17(3)36-26(32-33-34-36)21-7-5-8-24(30-21)31-27(38)19-12-23(16(2)11-20(19)28)35-13-22(29-15-35)18-9-10-18/h5,7-8,11-13,15,17-18H,4,6,9-10,14H2,1-3H3,(H,30,31,38)/t17-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 55n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445423
PNG
(US10683279, Example 20a)
Show SMILES C[C@H](CNC(C)=O)n1nnnc1-c1cccc(NC(=O)c2cc(c(C)cc2F)-n2cnc(c2)C2CC2)n1
Show InChI InChI=1S/C25H26FN9O2/c1-14-9-19(26)18(10-22(14)34-12-21(28-13-34)17-7-8-17)25(37)30-23-6-4-5-20(29-23)24-31-32-33-35(24)15(2)11-27-16(3)36/h4-6,9-10,12-13,15,17H,7-8,11H2,1-3H3,(H,27,36)(H,29,30,37)/t15-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 55n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445468
PNG
(US10683279, Example 4b)
Show SMILES CC(C)c1nnnn1-c1cccc(NC(=O)c2cc(c(C)cn2)-n2cnc(c2)C(F)(F)F)n1
Show InChI InChI=1S/C20H18F3N9O/c1-11(2)18-28-29-30-32(18)17-6-4-5-16(26-17)27-19(33)13-7-14(12(3)8-24-13)31-9-15(25-10-31)20(21,22)23/h4-11H,1-3H3,(H,26,27,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 55n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445437
PNG
(US10683279, Example 34a)
Show SMILES CC(C)n1nnnc1-c1nccc(NC(=O)c2cc(c(C)cc2F)-n2cnc(c2)C2CC2)n1
Show InChI InChI=1S/C22H22FN9O/c1-12(2)32-21(28-29-30-32)20-24-7-6-19(26-20)27-22(33)15-9-18(13(3)8-16(15)23)31-10-17(25-11-31)14-4-5-14/h6-12,14H,4-5H2,1-3H3,(H,24,26,27,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 55n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445438
PNG
(US10683279, Example 35a)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc(c(C)cc2F)-n2cnc(c2)C2CC2)c1
Show InChI InChI=1S/C24H24FN7O/c1-14(2)32-23(28-29-30-32)17-5-4-6-18(10-17)27-24(33)19-11-22(15(3)9-20(19)25)31-12-21(26-13-31)16-7-8-16/h4-6,9-14,16H,7-8H2,1-3H3,(H,27,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 55n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445412
PNG
(US10683279, Example 9a)
Show SMILES CC(C)Cn1nnnc1-c1cccc(NC(=O)c2cc(c(C)cc2F)-n2cnc(c2)C2CC2)n1
Show InChI InChI=1S/C24H25FN8O/c1-14(2)11-33-23(29-30-31-33)19-5-4-6-22(27-19)28-24(34)17-10-21(15(3)9-18(17)25)32-12-20(26-13-32)16-7-8-16/h4-6,9-10,12-14,16H,7-8,11H2,1-3H3,(H,27,28,34)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 55n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445419
PNG
(US10683279, Example 16a)
Show SMILES CC(n1nnnc1-c1cccc(NC(=O)c2cc(c(C)cc2F)-n2cnc(c2)C2CC2)n1)C(F)(F)F
Show InChI InChI=1S/C23H20F4N8O/c1-12-8-16(24)15(9-19(12)34-10-18(28-11-34)14-6-7-14)22(36)30-20-5-3-4-17(29-20)21-31-32-33-35(21)13(2)23(25,26)27/h3-5,8-11,13-14H,6-7H2,1-2H3,(H,29,30,36)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 55n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445451
PNG
(US10683279, Example 48a)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc(c(C)cn2)-n2cnc(c2)C2CC2)n1
Show InChI InChI=1S/C22H23N9O/c1-13(2)31-21(27-28-29-31)16-5-4-6-20(25-16)26-22(32)17-9-19(14(3)10-23-17)30-11-18(24-12-30)15-7-8-15/h4-6,9-13,15H,7-8H2,1-3H3,(H,25,26,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 55n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445474
PNG
(US10683279, Example 4c)
Show SMILES CC(C)n1nncc1-c1cccc(NC(=O)c2cc(c(C)cc2F)-n2cnc(c2)C2CC2)n1
Show InChI InChI=1S/C24H24FN7O/c1-14(2)32-22(11-27-30-32)19-5-4-6-23(28-19)29-24(33)17-10-21(15(3)9-18(17)25)31-12-20(26-13-31)16-7-8-16/h4-6,9-14,16H,7-8H2,1-3H3,(H,28,29,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 55n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445472
PNG
(US10683279, Example 2c)
Show SMILES Cc1cc(F)c(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc(n1)-n1cnnc1
Show InChI InChI=1S/C21H18FN7O/c1-13-7-16(22)15(8-18(13)28-9-17(23-10-28)14-5-6-14)21(30)27-19-3-2-4-20(26-19)29-11-24-25-12-29/h2-4,7-12,14H,5-6H2,1H3,(H,26,27,30)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>100n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445439
PNG
(US10683279, Example 36a)
Show SMILES Cc1cc(F)c(cc1-n1cnc(c1)C1CC1)C(=O)Nc1ccnc(n1)C1=NN=NC1
Show InChI InChI=1S/C20H17FN8O/c1-11-6-14(21)13(7-17(11)29-9-16(23-10-29)12-2-3-12)20(30)26-18-4-5-22-19(25-18)15-8-24-28-27-15/h4-7,9-10,12H,2-3,8H2,1H3,(H,22,25,26,30)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>100n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445428
PNG
(US10683279, Example 25a)
Show SMILES C[C@H](COC(=O)c1ccccc1)n1nnnc1-c1cccc(NC(=O)c2cc(c(C)cc2F)-n2cnc(c2)C2CC2)n1
Show InChI InChI=1S/C30H27FN8O3/c1-18-13-23(31)22(14-26(18)38-15-25(32-17-38)20-11-12-20)29(40)34-27-10-6-9-24(33-27)28-35-36-37-39(28)19(2)16-42-30(41)21-7-4-3-5-8-21/h3-10,13-15,17,19-20H,11-12,16H2,1-2H3,(H,33,34,40)/t19-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>100n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445473
PNG
(US10683279, Example 3c)
Show SMILES CC(C)c1nccn1-c1cccc(NC(=O)c2cc(c(C)cc2F)-n2cnc(c2)C2CC2)n1
Show InChI InChI=1S/C25H25FN6O/c1-15(2)24-27-9-10-32(24)23-6-4-5-22(29-23)30-25(33)18-12-21(16(3)11-19(18)26)31-13-20(28-14-31)17-7-8-17/h4-6,9-15,17H,7-8H2,1-3H3,(H,29,30,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>100n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445466
PNG
(US10683279, Example 2b)
Show SMILES CC(C)c1nnnn1-c1cccc(NC(=O)c2cc(c(C)cc2F)-n2cnc(c2)C(F)(F)F)n1
Show InChI InChI=1S/C21H18F4N8O/c1-11(2)19-29-30-31-33(19)18-6-4-5-17(27-18)28-20(34)13-8-15(12(3)7-14(13)22)32-9-16(26-10-32)21(23,24)25/h4-11H,1-3H3,(H,27,28,34)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>100n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445422
PNG
(US10683279, Example 19a)
Show SMILES CC(C(O)=O)n1nnnc1-c1cccc(NC(=O)c2cc(c(C)cc2F)-n2cnc(c2)C2CC2)n1
Show InChI InChI=1S/C23H21FN8O3/c1-12-8-16(24)15(9-19(12)31-10-18(25-11-31)14-6-7-14)22(33)27-20-5-3-4-17(26-20)21-28-29-30-32(21)13(2)23(34)35/h3-5,8-11,13-14H,6-7H2,1-2H3,(H,34,35)(H,26,27,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>100n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445409
PNG
((R)-2-(5-(6-(5-(4-cyclopropyl-1H-imidazol-1-yl)-2-...)
Show SMILES C[C@H](COC(C)=O)n1nnnc1-c1cccc(NC(=O)c2cc(c(C)cc2F)-n2cnc(c2)C2CC2)n1
Show InChI InChI=1S/C25H25FN8O3/c1-14-9-19(26)18(10-22(14)33-11-21(27-13-33)17-7-8-17)25(36)29-23-6-4-5-20(28-23)24-30-31-32-34(24)15(2)12-37-16(3)35/h4-6,9-11,13,15,17H,7-8,12H2,1-3H3,(H,28,29,36)/t15-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>100n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM445465
PNG
(US10683279, Example 1b | US10683279, Example 1c)
Show SMILES CC(C)c1nnnn1-c1cccc(NC(=O)c2cc(c(C)cc2F)-n2cnc(c2)C2CC2)n1
Show InChI InChI=1S/C23H23FN8O/c1-13(2)22-28-29-30-32(22)21-6-4-5-20(26-21)27-23(33)16-10-19(14(3)9-17(16)24)31-11-18(25-12-31)15-7-8-15/h4-6,9-13,15H,7-8H2,1-3H3,(H,26,27,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>100n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...


US Patent US10683279 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%