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Patent code US10683294

Compile Data Set for Download or QSAR
Found 67 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445627
PNG
(US10683294, Compound 1.032)
Show SMILES CCc1cccc(CC)c1-n1nc2c(CN(CC(C)(C)C)C2(C)C)c1-c1ccc(F)c2[nH]ccc12
Show InChI InChI=1S/C30H37FN4/c1-8-19-11-10-12-20(9-2)26(19)35-27(22-13-14-24(31)25-21(22)15-16-32-25)23-17-34(18-29(3,4)5)30(6,7)28(23)33-35/h10-16,32H,8-9,17-18H2,1-7H3
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n/an/a<5n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445597
PNG
(US10683294, Compound 1.002)
Show SMILES CCc1cccc(CC)c1-n1nc2c(CN(Cc3ccc(cc3C(F)(F)F)C(F)(F)F)C2(C)C)c1-c1cc(F)c(OC)c2[nH]ccc12
Show InChI InChI=1S/C35H33F7N4O/c1-6-19-9-8-10-20(7-2)29(19)46-30(24-16-27(36)31(47-5)28-23(24)13-14-43-28)25-18-45(33(3,4)32(25)44-46)17-21-11-12-22(34(37,38)39)15-26(21)35(40,41)42/h8-16,43H,6-7,17-18H2,1-5H3
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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445612
PNG
(US10683294, Compound 1.017)
Show SMILES CCc1cccc(CC)c1-n1nc2c(CN(Cc3ccc(F)cc3F)C2(C)C)c1-c1ccc(F)c2[nH]cc(Cl)c12
Show InChI InChI=1S/C32H30ClF3N4/c1-5-18-8-7-9-19(6-2)29(18)40-30(22-12-13-25(35)28-27(22)24(33)15-37-28)23-17-39(32(3,4)31(23)38-40)16-20-10-11-21(34)14-26(20)36/h7-15,37H,5-6,16-17H2,1-4H3
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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445632
PNG
(US10683294, Compound 1.037)
Show SMILES CCc1cccc(CC)c1-n1nc2c(CN(Cc3ccc(cc3C(F)(F)F)C(F)(F)F)C2(C)C)c1-c1c(F)cc(F)c2[nH]ccc12
Show InChI InChI=1S/C34H30F8N4/c1-5-18-8-7-9-19(6-2)29(18)46-30(27-22-12-13-43-28(22)26(36)15-25(27)35)23-17-45(32(3,4)31(23)44-46)16-20-10-11-21(33(37,38)39)14-24(20)34(40,41)42/h7-15,43H,5-6,16-17H2,1-4H3
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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445618
PNG
(US10683294, Compound 1.023)
Show SMILES CCc1cccc(CC)c1-n1nc2c(CN(Cc3ccc(F)cc3)C2(C)C)c1-c1ccc(F)c2[nH]ccc12
Show InChI InChI=1S/C32H32F2N4/c1-5-21-8-7-9-22(6-2)29(21)38-30(25-14-15-27(34)28-24(25)16-17-35-28)26-19-37(32(3,4)31(26)36-38)18-20-10-12-23(33)13-11-20/h7-17,35H,5-6,18-19H2,1-4H3
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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445599
PNG
(US10683294, Compound 1.004)
Show SMILES CCc1cccc(CC)c1-n1nc2c(CN(Cc3ccc(cc3C(F)(F)F)C(F)(F)F)C2(C)C)c1-c1ccc(CO)c2[nH]ccc12
Show InChI InChI=1S/C35H34F6N4O/c1-5-20-8-7-9-21(6-2)30(20)45-31(26-13-11-23(19-46)29-25(26)14-15-42-29)27-18-44(33(3,4)32(27)43-45)17-22-10-12-24(34(36,37)38)16-28(22)35(39,40)41/h7-16,42,46H,5-6,17-19H2,1-4H3
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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445620
PNG
(US10683294, Compound 1.025)
Show SMILES CCc1cccc(CC)c1-n1nc2c(CN(Cc3ccc(cc3C(F)(F)F)C(F)(F)F)C2(C)C)c1-c1ccc(C)c2[nH]ccc12
Show InChI InChI=1S/C35H34F6N4/c1-6-21-9-8-10-22(7-2)30(21)45-31(26-14-11-20(3)29-25(26)15-16-42-29)27-19-44(33(4,5)32(27)43-45)18-23-12-13-24(34(36,37)38)17-28(23)35(39,40)41/h8-17,42H,6-7,18-19H2,1-5H3
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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445621
PNG
(US10683294, Compound 1.026)
Show SMILES CCc1cccc(CC)c1-n1nc2c(CN(Cc3ccccc3C(F)(F)F)C2(C)C)c1-c1ccc(F)c2[nH]cc(Cl)c12
Show InChI InChI=1S/C33H31ClF4N4/c1-5-19-11-9-12-20(6-2)29(19)42-30(22-14-15-26(35)28-27(22)25(34)16-39-28)23-18-41(32(3,4)31(23)40-42)17-21-10-7-8-13-24(21)33(36,37)38/h7-16,39H,5-6,17-18H2,1-4H3
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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445616
PNG
(US10683294, Compound 1.021)
Show SMILES CCc1cccc(CC)c1-n1nc2c(CN(Cc3ccccc3)C2(C)C)c1-c1ccc(F)c2[nH]ccc12
Show InChI InChI=1S/C32H33FN4/c1-5-22-13-10-14-23(6-2)29(22)37-30(25-15-16-27(33)28-24(25)17-18-34-28)26-20-36(32(3,4)31(26)35-37)19-21-11-8-7-9-12-21/h7-18,34H,5-6,19-20H2,1-4H3
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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445619
PNG
(US10683294, Compound 1.024)
Show SMILES CCc1cccc(CC)c1-n1nc2c(CN(Cc3ccc(cc3C(F)(F)F)C(F)(F)F)C2(C)C)c1-c1ccc(Cl)c2[nH]ccc12
Show InChI InChI=1S/C34H31ClF6N4/c1-5-19-8-7-9-20(6-2)29(19)45-30(24-12-13-27(35)28-23(24)14-15-42-28)25-18-44(32(3,4)31(25)43-45)17-21-10-11-22(33(36,37)38)16-26(21)34(39,40)41/h7-16,42H,5-6,17-18H2,1-4H3
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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445605
PNG
(US10683294, Compound 1.010)
Show SMILES CCc1cccc(CC)c1-n1nc2c(CN(Cc3ccc(cc3C(F)(F)F)C(F)(F)F)C2(C)C)c1-c1cccc2[nH]cc(F)c12
Show InChI InChI=1S/C34H31F7N4/c1-5-19-9-7-10-20(6-2)29(19)45-30(23-11-8-12-27-28(23)26(35)16-42-27)24-18-44(32(3,4)31(24)43-45)17-21-13-14-22(33(36,37)38)15-25(21)34(39,40)41/h7-16,42H,5-6,17-18H2,1-4H3
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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445607
PNG
(US10683294, Compound 1.012)
Show SMILES CCc1cccc(CC)c1-n1nc2c(CN(Cc3ccc(F)cc3Cl)C2(C)C)c1-c1ccc(F)c2[nH]ccc12
Show InChI InChI=1S/C32H31ClF2N4/c1-5-19-8-7-9-20(6-2)29(19)39-30(24-12-13-27(35)28-23(24)14-15-36-28)25-18-38(32(3,4)31(25)37-39)17-21-10-11-22(34)16-26(21)33/h7-16,36H,5-6,17-18H2,1-4H3
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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445608
PNG
(US10683294, Compound 1.013)
Show SMILES CCc1cccc(CC)c1-n1nc2c(CN(Cc3ccc(F)cc3F)C2(C)C)c1-c1ccc(F)c2[nH]ccc12
Show InChI InChI=1S/C32H31F3N4/c1-5-19-8-7-9-20(6-2)29(19)39-30(24-12-13-26(34)28-23(24)14-15-36-28)25-18-38(32(3,4)31(25)37-39)17-21-10-11-22(33)16-27(21)35/h7-16,36H,5-6,17-18H2,1-4H3
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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445617
PNG
(US10683294, Compound 1.022)
Show SMILES CCc1cccc(CC)c1-n1nc2c(CN(Cc3ccccc3F)C2(C)C)c1-c1ccc(F)c2[nH]ccc12
Show InChI InChI=1S/C32H32F2N4/c1-5-20-11-9-12-21(6-2)29(20)38-30(24-14-15-27(34)28-23(24)16-17-35-28)25-19-37(32(3,4)31(25)36-38)18-22-10-7-8-13-26(22)33/h7-17,35H,5-6,18-19H2,1-4H3
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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445631
PNG
(US10683294, Compound 1.036)
Show SMILES CCc1cccc(CC)c1-n1nc2c(CN(Cc3ccc(cc3C(F)(F)F)C(F)(F)F)C2(C)C)c1-c1cccc2[nH]cc(C#N)c12
Show InChI InChI=1S/C35H31F6N5/c1-5-20-9-7-10-21(6-2)30(20)46-31(25-11-8-12-28-29(25)23(16-42)17-43-28)26-19-45(33(3,4)32(26)44-46)18-22-13-14-24(34(36,37)38)15-27(22)35(39,40)41/h7-15,17,43H,5-6,18-19H2,1-4H3
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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445633
PNG
(US10683294, Compound 1.038)
Show SMILES CCc1cccc(CC)c1-n1nc2c(CN(Cc3cc(ccc3C(F)(F)F)C(F)(F)F)C2(C)C)c1-c1cccc2[nH]ccc12
Show InChI InChI=1S/C34H32F6N4/c1-5-20-9-7-10-21(6-2)29(20)44-30(25-11-8-12-28-24(25)15-16-41-28)26-19-43(32(3,4)31(26)42-44)18-22-17-23(33(35,36)37)13-14-27(22)34(38,39)40/h7-17,41H,5-6,18-19H2,1-4H3
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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445614
PNG
(US10683294, Compound 1.019)
Show SMILES CCc1cccc(CC)c1-n1nc2c(CN(Cc3ccccn3)C2(C)C)c1-c1ccc(F)c2[nH]ccc12
Show InChI InChI=1S/C31H32FN5/c1-5-20-10-9-11-21(6-2)28(20)37-29(24-13-14-26(32)27-23(24)15-17-34-27)25-19-36(31(3,4)30(25)35-37)18-22-12-7-8-16-33-22/h7-17,34H,5-6,18-19H2,1-4H3
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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445634
PNG
(US10683294, Compound 1.039)
Show SMILES CCc1cccc(CC)c1-n1nc2c(CN(Cc3ccc(cc3C(F)(F)F)C(F)(F)F)C2(C)C)c1-c1ccc(F)c2[nH]ccc12
Show InChI InChI=1S/C34H31F7N4/c1-5-19-8-7-9-20(6-2)29(19)45-30(24-12-13-27(35)28-23(24)14-15-42-28)25-18-44(32(3,4)31(25)43-45)17-21-10-11-22(33(36,37)38)16-26(21)34(39,40)41/h7-16,42H,5-6,17-18H2,1-4H3
PDB

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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445638
PNG
(US10683294, Compound 1.043)
Show SMILES CCc1cccc(CC)c1-n1nc2c(CN(Cc3ccc(cc3C(F)(F)F)C(F)(F)F)C2(C)C)c1-c1c(F)ccc2[nH]ccc12
Show InChI InChI=1S/C34H31F7N4/c1-5-19-8-7-9-20(6-2)29(19)45-30(28-23-14-15-42-27(23)13-12-26(28)35)24-18-44(32(3,4)31(24)43-45)17-21-10-11-22(33(36,37)38)16-25(21)34(39,40)41/h7-16,42H,5-6,17-18H2,1-4H3
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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445639
PNG
(US10683294, Compound 1.044)
Show SMILES CCc1cccc(CC)c1-n1nc2c(CN(Cc3ccccc3C(F)(F)F)C2(C)C)c1-c1cccc2[nH]ccc12
Show InChI InChI=1S/C33H33F3N4/c1-5-21-12-9-13-22(6-2)29(21)40-30(25-14-10-16-28-24(25)17-18-37-28)26-20-39(32(3,4)31(26)38-40)19-23-11-7-8-15-27(23)33(34,35)36/h7-18,37H,5-6,19-20H2,1-4H3
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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445613
PNG
(US10683294, Compound 1.018)
Show SMILES CCc1cccc(CC)c1-n1nc2c(CN(Cc3cccc(F)c3)C2(C)C)c1-c1ccc(F)c2[nH]ccc12
Show InChI InChI=1S/C32H32F2N4/c1-5-21-10-8-11-22(6-2)29(21)38-30(25-13-14-27(34)28-24(25)15-16-35-28)26-19-37(32(3,4)31(26)36-38)18-20-9-7-12-23(33)17-20/h7-17,35H,5-6,18-19H2,1-4H3
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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445643
PNG
(US10683294, Compound 1.048)
Show SMILES CCc1cccc(CC)c1-n1nc2c(CN(C(=O)OC(C)(C)C)C2(C)C)c1-c1ccc2[nH]ccc2c1
Show InChI InChI=1S/C30H36N4O2/c1-8-19-11-10-12-20(9-2)25(19)34-26(22-13-14-24-21(17-22)15-16-31-24)23-18-33(28(35)36-29(3,4)5)30(6,7)27(23)32-34/h10-17,31H,8-9,18H2,1-7H3
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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445622
PNG
(US10683294, Compound 1.027)
Show SMILES CCc1cccc(CC)c1-n1nc2c(CN(Cc3ccc(cc3C(F)(F)F)C(F)(F)F)C2(C)C)c1-c1cc(F)c2[nH]ccc2c1
Show InChI InChI=1S/C34H31F7N4/c1-5-19-8-7-9-20(6-2)29(19)45-30(23-14-21-12-13-42-28(21)27(35)15-23)25-18-44(32(3,4)31(25)43-45)17-22-10-11-24(33(36,37)38)16-26(22)34(39,40)41/h7-16,42H,5-6,17-18H2,1-4H3
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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445628
PNG
(US10683294, Compound 1.033)
Show SMILES CCc1cccc(CC)c1-n1nc2c(CN(C(=O)C(C)(C)C)C2(C)C)c1-c1ccc(F)c2[nH]ccc12
Show InChI InChI=1S/C30H35FN4O/c1-8-18-11-10-12-19(9-2)25(18)35-26(21-13-14-23(31)24-20(21)15-16-32-24)22-17-34(28(36)29(3,4)5)30(6,7)27(22)33-35/h10-16,32H,8-9,17H2,1-7H3
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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445637
PNG
(US10683294, Compound 1.042)
Show SMILES CCc1cccc(CC)c1-n1nc2c(CN(Cc3cc(Cl)ccc3Cl)C2(C)C)c1-c1cccc2[nH]ccc12
Show InChI InChI=1S/C32H32Cl2N4/c1-5-20-9-7-10-21(6-2)29(20)38-30(25-11-8-12-28-24(25)15-16-35-28)26-19-37(32(3,4)31(26)36-38)18-22-17-23(33)13-14-27(22)34/h7-17,35H,5-6,18-19H2,1-4H3
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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445640
PNG
(US10683294, Compound 1.045)
Show SMILES CCc1cccc(CC)c1-n1nc2c(CN(Cc3ccc(cc3C(F)(F)F)C(F)(F)F)C2(C)C)c1-c1cccc2[nH]ccc12
Show InChI InChI=1S/C34H32F6N4/c1-5-20-9-7-10-21(6-2)29(20)44-30(25-11-8-12-28-24(25)15-16-41-28)26-19-43(32(3,4)31(26)42-44)18-22-13-14-23(33(35,36)37)17-27(22)34(38,39)40/h7-17,41H,5-6,18-19H2,1-4H3
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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445624
PNG
(US10683294, Compound 1.029)
Show SMILES CCc1cccc(CC)c1-n1nc2c(CN(Cc3ccccc3C(F)(F)F)C2(C)C)c1-c1ccc(F)c2[nH]ccc12
Show InChI InChI=1S/C33H32F4N4/c1-5-20-11-9-12-21(6-2)29(20)41-30(24-14-15-27(34)28-23(24)16-17-38-28)25-19-40(32(3,4)31(25)39-41)18-22-10-7-8-13-26(22)33(35,36)37/h7-17,38H,5-6,18-19H2,1-4H3
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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445625
PNG
(US10683294, Compound 1.030)
Show SMILES CCc1cccc(CC)c1-n1nc2c(CN(C(=O)CC(C)C)C2(C)C)c1-c1ccc(F)c2[nH]ccc12
Show InChI InChI=1S/C30H35FN4O/c1-7-19-10-9-11-20(8-2)27(19)35-28(22-12-13-24(31)26-21(22)14-15-32-26)23-17-34(25(36)16-18(3)4)30(5,6)29(23)33-35/h9-15,18,32H,7-8,16-17H2,1-6H3
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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445645
PNG
(US10683294, Compound 1.050)
Show SMILES CCOC(=O)C(N1Cc2c(nn(c2-c2ccc3[nH]ccc3c2)-c2c(CC)cccc2CC)C1(C)C)c1ccccc1
PDB

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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445610
PNG
(US10683294, Compound 1.015)
Show SMILES CCc1cccc(CC)c1-n1nc2c(CN(Cc3ccc(Cl)cc3F)C2(C)C)c1-c1ccc(F)c2[nH]cc(Cl)c12
Show InChI InChI=1S/C32H30Cl2F2N4/c1-5-18-8-7-9-19(6-2)29(18)40-30(22-12-13-25(35)28-27(22)24(34)15-37-28)23-17-39(32(3,4)31(23)38-40)16-20-10-11-21(33)14-26(20)36/h7-15,37H,5-6,16-17H2,1-4H3
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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445647
PNG
(US10683294, Compound 1.052)
Show SMILES Cc1cccc(C)c1-n1nc2c(CN(CC(C)(C)C)C2(C)C)c1-c1ccc2[nH]ccc2c1
Show InChI InChI=1S/C28H34N4/c1-18-9-8-10-19(2)24(18)32-25(21-11-12-23-20(15-21)13-14-29-23)22-16-31(17-27(3,4)5)28(6,7)26(22)30-32/h8-15,29H,16-17H2,1-7H3
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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445642
PNG
(US10683294, Compound 1.047)
Show SMILES CCc1cccc(CC)c1-n1nc2c(CN(Cc3ccccc3C(F)(F)F)C2(C)C)c1-c1ccc2[nH]ccc2c1
Show InChI InChI=1S/C33H33F3N4/c1-5-21-11-9-12-22(6-2)29(21)40-30(24-14-15-28-23(18-24)16-17-37-28)26-20-39(32(3,4)31(26)38-40)19-25-10-7-8-13-27(25)33(34,35)36/h7-18,37H,5-6,19-20H2,1-4H3
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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445629
PNG
(US10683294, Compound 1.034)
Show SMILES CCc1cccc(CC)c1-n1nc2c(CN(Cc3ccc(cc3C(F)(F)F)C(F)(F)F)C2(C)C)c1-c1cccc2[nH]cc(Cl)c12
Show InChI InChI=1S/C34H31ClF6N4/c1-5-19-9-7-10-20(6-2)29(19)45-30(23-11-8-12-27-28(23)26(35)16-42-27)24-18-44(32(3,4)31(24)43-45)17-21-13-14-22(33(36,37)38)15-25(21)34(39,40)41/h7-16,42H,5-6,17-18H2,1-4H3
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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445615
PNG
(US10683294, Compound 1.020)
Show SMILES CCc1cccc(CC)c1-n1nc2c(CN(Cc3ccc(Cl)cc3Cl)C2(C)C)c1-c1ccc(F)c2[nH]ccc12
Show InChI InChI=1S/C32H31Cl2FN4/c1-5-19-8-7-9-20(6-2)29(19)39-30(24-12-13-27(35)28-23(24)14-15-36-28)25-18-38(32(3,4)31(25)37-39)17-21-10-11-22(33)16-26(21)34/h7-16,36H,5-6,17-18H2,1-4H3
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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445641
PNG
(US10683294, Compound 1.046)
Show SMILES CCc1cccc(CC)c1-n1nc2c(CN(Cc3cc(Cl)ccc3Cl)C2(C)C)c1-c1ccc2[nH]ccc2c1
Show InChI InChI=1S/C32H32Cl2N4/c1-5-20-8-7-9-21(6-2)29(20)38-30(23-10-13-28-22(16-23)14-15-35-28)26-19-37(32(3,4)31(26)36-38)18-24-17-25(33)11-12-27(24)34/h7-17,35H,5-6,18-19H2,1-4H3
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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445626
PNG
(US10683294, Compound 1.031)
Show SMILES CCc1cccc(CC)c1-n1nc2c(CN(Cc3ccc(cc3C(F)(F)F)C(F)(F)F)C2(C)C)c1-c1cc(F)cc2[nH]ccc12
Show InChI InChI=1S/C34H31F7N4/c1-5-19-8-7-9-20(6-2)29(19)45-30(25-15-23(35)16-28-24(25)12-13-42-28)26-18-44(32(3,4)31(26)43-45)17-21-10-11-22(33(36,37)38)14-27(21)34(39,40)41/h7-16,42H,5-6,17-18H2,1-4H3
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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445630
PNG
(US10683294, Compound 1.035)
Show SMILES CCc1cccc(CC)c1-n1nc2c(CN(Cc3ccc(cc3C(F)(F)F)C(F)(F)F)C2(C)C)c1-c1cccc2[nH]cc(C)c12
Show InChI InChI=1S/C35H34F6N4/c1-6-21-10-8-11-22(7-2)30(21)45-31(25-12-9-13-28-29(25)20(3)17-42-28)26-19-44(33(4,5)32(26)43-45)18-23-14-15-24(34(36,37)38)16-27(23)35(39,40)41/h8-17,42H,6-7,18-19H2,1-5H3
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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445596
PNG
(US10683294, Compound 1.001)
Show SMILES CCc1cccc(CC)c1-n1nc2c(CN(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)C2(C)C)c1-c1ccc(F)c2[nH]ccc12
Show InChI InChI=1S/C34H31F7N4/c1-5-20-8-7-9-21(6-2)29(20)45-30(25-10-11-27(35)28-24(25)12-13-42-28)26-18-44(32(3,4)31(26)43-45)17-19-14-22(33(36,37)38)16-23(15-19)34(39,40)41/h7-16,42H,5-6,17-18H2,1-4H3
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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445606
PNG
(US10683294, Compound 1.011)
Show SMILES CCc1cccc(CC)c1-n1nc2c(CN(Cc3ccc(cc3C(F)(F)F)C(F)(F)F)C2(C)C)c1-c1ccc(F)c2[nH]cc(Cl)c12
Show InChI InChI=1S/C34H30ClF7N4/c1-5-18-8-7-9-19(6-2)29(18)46-30(22-12-13-26(36)28-27(22)25(35)15-43-28)23-17-45(32(3,4)31(23)44-46)16-20-10-11-21(33(37,38)39)14-24(20)34(40,41)42/h7-15,43H,5-6,16-17H2,1-4H3
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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445602
PNG
(US10683294, Compound 1.007)
Show SMILES CCc1cccc(CC)c1-n1nc2c(CN(C(=O)CNC(=O)OC(C)(C)C)C2(C)C)c1-c1ccc(F)c2[nH]ccc12
Show InChI InChI=1S/C32H38FN5O3/c1-8-19-11-10-12-20(9-2)27(19)38-28(22-13-14-24(33)26-21(22)15-16-34-26)23-18-37(32(6,7)29(23)36-38)25(39)17-35-30(40)41-31(3,4)5/h10-16,34H,8-9,17-18H2,1-7H3,(H,35,40)
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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445623
PNG
(US10683294, Compound 1.028)
Show SMILES CCc1cccc(CC)c1-n1nc2c(CN(C(=O)c3ccccn3)C2(C)C)c1-c1ccc(F)c2[nH]ccc12
Show InChI InChI=1S/C31H30FN5O/c1-5-19-10-9-11-20(6-2)27(19)37-28(22-13-14-24(32)26-21(22)15-17-34-26)23-18-36(31(3,4)29(23)35-37)30(38)25-12-7-8-16-33-25/h7-17,34H,5-6,18H2,1-4H3
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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445604
PNG
(US10683294, Compound 1.009)
Show SMILES CCc1cccc(CC)c1-n1nc2c(CN(CC(C)(C)O)C2(C)C)c1-c1ccc(F)c2[nH]ccc12
Show InChI InChI=1S/C29H35FN4O/c1-7-18-10-9-11-19(8-2)25(18)34-26(21-12-13-23(30)24-20(21)14-15-31-24)22-16-33(17-28(3,4)35)29(5,6)27(22)32-34/h9-15,31,35H,7-8,16-17H2,1-6H3
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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445644
PNG
(US10683294, Compound 1.049)
Show SMILES CCc1cccc(CC)c1-n1nc2c(CN(C(c3ccccc3)C(C)(C)O)C2(C)C)c1-c1ccc2[nH]ccc2c1
PDB

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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445609
PNG
(US10683294, Compound 1.014)
Show SMILES CCc1cccc(CC)c1-n1nc2c(CN(Cc3ccncc3)C2(C)C)c1-c1ccc(F)c2[nH]ccc12
Show InChI InChI=1S/C31H32FN5/c1-5-21-8-7-9-22(6-2)28(21)37-29(24-10-11-26(32)27-23(24)14-17-34-27)25-19-36(31(3,4)30(25)35-37)18-20-12-15-33-16-13-20/h7-17,34H,5-6,18-19H2,1-4H3
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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445655
PNG
(US10683294, Compound 1.060)
Show SMILES CC(C1CCCCC1)C(=O)N1Cc2nn(c(c2C1)-c1ccc2[nH]ccc2c1)-c1c(C)cccc1C
PDB

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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445603
PNG
(US10683294, Compound 1.008)
Show SMILES CCc1cccc(CC)c1-n1nc2c(CN(Cc3ncco3)C2(C)C)c1-c1ccc(F)c2[nH]ccc12
Show InChI InChI=1S/C29H30FN5O/c1-5-18-8-7-9-19(6-2)26(18)35-27(21-10-11-23(30)25-20(21)12-13-32-25)22-16-34(17-24-31-14-15-36-24)29(3,4)28(22)33-35/h7-15,32H,5-6,16-17H2,1-4H3
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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445611
PNG
(US10683294, Compound 1.016)
Show SMILES CCc1cccc(CC)c1-n1nc2c(CN(Cc3cccnc3)C2(C)C)c1-c1ccc(F)c2[nH]ccc12
Show InChI InChI=1S/C31H32FN5/c1-5-21-10-7-11-22(6-2)28(21)37-29(24-12-13-26(32)27-23(24)14-16-34-27)25-19-36(31(3,4)30(25)35-37)18-20-9-8-15-33-17-20/h7-17,34H,5-6,18-19H2,1-4H3
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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445648
PNG
(US10683294, Compound 1.053)
Show SMILES Cc1cccc(C)c1-n1nc2CN(CC(C)(C)C)Cc2c1-c1ccc2[nH]ccc2c1
Show InChI InChI=1S/C26H30N4/c1-17-7-6-8-18(2)24(17)30-25(20-9-10-22-19(13-20)11-12-27-22)21-14-29(15-23(21)28-30)16-26(3,4)5/h6-13,27H,14-16H2,1-5H3
PDB

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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445636
PNG
(US10683294, Compound 1.041)
Show SMILES CCc1cccc(CC)c1-n1nc2c(CN(C(=O)COc3ccccc3)C2(C)C)c1-c1cccc2[nH]ccc12
Show InChI InChI=1S/C33H34N4O2/c1-5-22-12-10-13-23(6-2)30(22)37-31(26-16-11-17-28-25(26)18-19-34-28)27-20-36(33(3,4)32(27)35-37)29(38)21-39-24-14-8-7-9-15-24/h7-19,34H,5-6,20-21H2,1-4H3
PDB

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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445662
PNG
(US10683294, Compound 1.067)
Show SMILES Cc1cccc(C)c1-n1nc2CN(Cc2c1-c1ccc2[nH]ccc2c1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C26H28N4O2/c1-16-7-6-8-17(2)23(16)30-24(19-9-10-21-18(13-19)11-12-27-21)20-14-29(15-22(20)28-30)25(31)32-26(3,4)5/h6-13,27H,14-15H2,1-5H3
PDB

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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445649
PNG
(US10683294, Compound 1.054)
Show SMILES CCOC(C)(C)C(=O)N1Cc2nn(c(c2C1)-c1ccc2[nH]ccc2c1)-c1c(C)cccc1C
Show InChI InChI=1S/C27H30N4O2/c1-6-33-27(4,5)26(32)30-15-21-23(16-30)29-31(24-17(2)8-7-9-18(24)3)25(21)20-10-11-22-19(14-20)12-13-28-22/h7-14,28H,6,15-16H2,1-5H3
PDB

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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445656
PNG
(US10683294, Compound 1.061)
Show SMILES Cc1cccc(C)c1-n1nc2CN(Cc2c1-c1ccc2[nH]ccc2c1)C(=O)CC(C)(C)C
Show InChI InChI=1S/C27H30N4O/c1-17-7-6-8-18(2)25(17)31-26(20-9-10-22-19(13-20)11-12-28-22)21-15-30(16-23(21)29-31)24(32)14-27(3,4)5/h6-13,28H,14-16H2,1-5H3
PDB

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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445652
PNG
(US10683294, Compound 1.057)
Show SMILES Cc1cccc(C)c1-n1nc2CN(Cc2c1-c1ccc2[nH]ccc2c1)C(=O)CC1CCCC1
Show InChI InChI=1S/C28H30N4O/c1-18-6-5-7-19(2)27(18)32-28(22-10-11-24-21(15-22)12-13-29-24)23-16-31(17-25(23)30-32)26(33)14-20-8-3-4-9-20/h5-7,10-13,15,20,29H,3-4,8-9,14,16-17H2,1-2H3
PDB

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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445600
PNG
(US10683294, Compound 1.005)
Show SMILES CCc1cccc(CC)c1-n1nc2c(CN(Cc3ccc(cc3C(F)(F)F)C(F)(F)F)C2(C)C)c1-c1ccc(C(O)=O)c2[nH]ccc12
Show InChI InChI=1S/C35H32F6N4O2/c1-5-19-8-7-9-20(6-2)29(19)45-30(24-12-13-25(32(46)47)28-23(24)14-15-42-28)26-18-44(33(3,4)31(26)43-45)17-21-10-11-22(34(36,37)38)16-27(21)35(39,40)41/h7-16,42H,5-6,17-18H2,1-4H3,(H,46,47)
PDB

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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445653
PNG
(US10683294, Compound 1.058)
Show SMILES Cc1cccc(C)c1-n1nc2CN(Cc2c1-c1ccc2[nH]ncc2c1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C25H27N5O2/c1-15-7-6-8-16(2)22(15)30-23(17-9-10-20-18(11-17)12-26-27-20)19-13-29(14-21(19)28-30)24(31)32-25(3,4)5/h6-12H,13-14H2,1-5H3,(H,26,27)
PDB

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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445601
PNG
(US10683294, Compound 1.006)
Show SMILES CCc1cccc(CC)c1-n1nc2c(CN(C(=O)CN)C2(C)C)c1-c1ccc(F)c2[nH]ccc12
Show InChI InChI=1S/C27H30FN5O/c1-5-16-8-7-9-17(6-2)24(16)33-25(19-10-11-21(28)23-18(19)12-13-30-23)20-15-32(22(34)14-29)27(3,4)26(20)31-33/h7-13,30H,5-6,14-15,29H2,1-4H3
PDB

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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445657
PNG
(US10683294, Compound 1.062)
Show SMILES CC(C)[C@H](O)C(=O)N1Cc2nn(c(c2C1)-c1ccc2[nH]ccc2c1)-c1c(C)cccc1C
PDB

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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445659
PNG
(US10683294, Compound 1.064)
Show SMILES Cc1cccc(C)c1-n1nc2CN(Cc2c1-c1ccc2[nH]ccc2c1)C(=O)c1ccc(cc1)C(C)(C)C
Show InChI InChI=1S/C32H32N4O/c1-20-7-6-8-21(2)29(20)36-30(24-11-14-27-23(17-24)15-16-33-27)26-18-35(19-28(26)34-36)31(37)22-9-12-25(13-10-22)32(3,4)5/h6-17,33H,18-19H2,1-5H3
PDB

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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445661
PNG
(US10683294, Compound 1.066)
Show SMILES Cc1cccc(C)c1-n1nc2CN(Cc2c1-c1ccc2[nH]ccc2c1)C(=O)c1ccccc1
Show InChI InChI=1S/C28H24N4O/c1-18-7-6-8-19(2)26(18)32-27(22-11-12-24-21(15-22)13-14-29-24)23-16-31(17-25(23)30-32)28(33)20-9-4-3-5-10-20/h3-15,29H,16-17H2,1-2H3
PDB

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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445598
PNG
(US10683294, Compound 1.003)
Show SMILES CCc1cccc(CC)c1-n1nc2c(CN(C(=O)NC(C)C)C2(C)C)c1-c1ccc(F)c2[nH]ccc12
Show InChI InChI=1S/C29H34FN5O/c1-7-18-10-9-11-19(8-2)25(18)35-26(21-12-13-23(30)24-20(21)14-15-31-24)22-16-34(28(36)32-17(3)4)29(5,6)27(22)33-35/h9-15,17,31H,7-8,16H2,1-6H3,(H,32,36)
PDB

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n/an/a>500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445650
PNG
(US10683294, Compound 1.055)
Show SMILES Cc1cccc(C)c1-n1nc2C(=O)N(Cc2c1-c1ccc2[nH]ccc2c1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C26H26N4O3/c1-15-7-6-8-16(2)22(15)30-23(18-9-10-20-17(13-18)11-12-27-20)19-14-29(24(31)21(19)28-30)25(32)33-26(3,4)5/h6-13,27H,14H2,1-5H3
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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445658
PNG
(US10683294, Compound 1.063)
Show SMILES Cc1cccc(C)c1-n1nc2CN(Cc2c1-c1ccc2[nH]ccc2c1)S(=O)(=O)c1ccc(cc1)C(C)(C)C
Show InChI InChI=1S/C31H32N4O2S/c1-20-7-6-8-21(2)29(20)35-30(23-9-14-27-22(17-23)15-16-32-27)26-18-34(19-28(26)33-35)38(36,37)25-12-10-24(11-13-25)31(3,4)5/h6-17,32H,18-19H2,1-5H3
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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445660
PNG
(US10683294, Compound 1.065)
Show SMILES Cc1cccc(C)c1-n1nc2CN(Cc2c1-c1ccc2[nH]ccc2c1)C(=O)NC(C)(C)C
Show InChI InChI=1S/C26H29N5O/c1-16-7-6-8-17(2)23(16)31-24(19-9-10-21-18(13-19)11-12-27-21)20-14-30(15-22(20)29-31)25(32)28-26(3,4)5/h6-13,27H,14-15H2,1-5H3,(H,28,32)
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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445635
PNG
(US10683294, Compound 1.040)
Show SMILES CCc1cccc(CC)c1-n1nc2c(CN(C(=O)Cn3nc(cc3C)C(F)(F)F)C2(C)C)c1-c1cccc2[nH]ccc12
Show InChI InChI=1S/C32H33F3N6O/c1-6-20-10-8-11-21(7-2)28(20)41-29(23-12-9-13-25-22(23)14-15-36-25)24-17-39(31(4,5)30(24)38-41)27(42)18-40-19(3)16-26(37-40)32(33,34)35/h8-16,36H,6-7,17-18H2,1-5H3
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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445646
PNG
(US10683294, Compound 1.051)
Show SMILES Cc1cccc(C)c1-n1nc2CN(CC(C)(C)C)Cc2c1-c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C25H29N5/c1-16-7-6-8-17(2)23(16)30-24(18-9-10-20-21(11-18)27-15-26-20)19-12-29(13-22(19)28-30)14-25(3,4)5/h6-11,15H,12-14H2,1-5H3,(H,26,27)
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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445654
PNG
(US10683294, Compound 1.059)
Show SMILES Cc1cccc(C)c1-n1nc2CN(Cc2c1-c1ccc2[nH]ccc2c1)C(=O)C1CCCC1
Show InChI InChI=1S/C27H28N4O/c1-17-6-5-7-18(2)25(17)31-26(21-10-11-23-20(14-21)12-13-28-23)22-15-30(16-24(22)29-31)27(32)19-8-3-4-9-19/h5-7,10-14,19,28H,3-4,8-9,15-16H2,1-2H3
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ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor


(Homo sapiens (Human))
BDBM445651
PNG
(US10683294, Compound 1.056)
Show SMILES Cc1cccc(C)c1-n1nc2CN(Cc2c1-c1ccc2[nH]ccc2c1)C(=O)CCC1CCCC1
Show InChI InChI=1S/C29H32N4O/c1-19-6-5-7-20(2)28(19)33-29(23-11-12-25-22(16-23)14-15-30-25)24-17-32(18-26(24)31-33)27(34)13-10-21-8-3-4-9-21/h5-7,11-12,14-16,21,30H,3-4,8-10,13,17-18H2,1-2H3
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n/an/a>500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...


US Patent US10683294 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%