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Patent code US10688093

Compile Data Set for Download or QSAR

Found 708 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM25116
PNG
(1-tert-butyl-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]...)
Show SMILES Cc1ccc(cc1)-c1nn(c2ncnc(N)c12)C(C)(C)C
Show InChI InChI=1S/C16H19N5/c1-10-5-7-11(8-6-10)13-12-14(17)18-9-19-15(12)21(20-13)16(2,3)4/h5-9H,1-4H3,(H2,17,18,19)
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n/an/a 6n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...


US Patent US10688093 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM50142887
PNG
(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
Show SMILES CC(C)(C)n1nc(-c2ccc(Cl)cc2)c2c(N)ncnc12
Show InChI InChI=1S/C15H16ClN5/c1-15(2,3)21-14-11(13(17)18-8-19-14)12(20-21)9-4-6-10(16)7-5-9/h4-8H,1-3H3,(H2,17,18,19)
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US Patent


Assay Description
The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...


US Patent US10688093 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM446703
PNG
(US10688093, Compound B50 (U.S. Pat. No.-8,492,377)...)
Show SMILES COc1cc2ncnc3Nc4c5OCOc5ccc4CN(CCCCCOc1cc23)C(=O)OCc1ccccc1
Show InChI InChI=1S/C30H30N4O6/c1-36-25-15-23-22-14-26(25)37-13-7-3-6-12-34(30(35)38-17-20-8-4-2-5-9-20)16-21-10-11-24-28(40-19-39-24)27(21)33-29(22)32-18-31-23/h2,4-5,8-11,14-15,18H,3,6-7,12-13,16-17,19H2,1H3,(H,31,32,33)
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US Patent


Assay Description
The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...


US Patent US10688093 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM446705
PNG
(N-{4-[2-(dimethyl- amino)ethoxy]- 3,5-dimethyl phe...)
Show SMILES COc1ccc2CCc3cnc(Nc4cc(C)c(OCCN(C)C)c(C)c4)nc3-c2c1
Show InChI InChI=1S/C25H30N4O2/c1-16-12-20(13-17(2)24(16)31-11-10-29(3)4)27-25-26-15-19-7-6-18-8-9-21(30-5)14-22(18)23(19)28-25/h8-9,12-15H,6-7,10-11H2,1-5H3,(H,26,27,28)
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US Patent


Assay Description
The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...


US Patent US10688093 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM446704
PNG
(9-methoxy-N-{3- methoxy-4-[3- (pyrrolidin-1-yl)pro...)
Show SMILES COc1ccc2c(c1)-c1nc(Nc3ccc(CCCN4CCCC4)c(OC)c3)ncc1CC2(C)C
Show InChI InChI=1S/C29H36N4O2/c1-29(2)18-21-19-30-28(32-27(21)24-17-23(34-3)11-12-25(24)29)31-22-10-9-20(26(16-22)35-4)8-7-15-33-13-5-6-14-33/h9-12,16-17,19H,5-8,13-15,18H2,1-4H3,(H,30,31,32)
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US Patent


Assay Description
The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...


US Patent US10688093 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM447401
PNG
(US10688093, Compound BF000817186)
Show SMILES COc1cc(ccc1O)-c1cnc2ccc(nn12)-c1ccc(O)c(OC)c1
Show InChI InChI=1S/C20H17N3O4/c1-26-18-9-12(3-6-16(18)24)14-5-8-20-21-11-15(23(20)22-14)13-4-7-17(25)19(10-13)27-2/h3-11,24-25H,1-2H3
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US Patent


Assay Description
The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...


US Patent US10688093 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM447061
PNG
(4-[6-(3,4- dimethoxyphenyl) imidazo[1,2- b]pyridaz...)
Show SMILES COc1ccc(cc1OC)-c1ccc2ncc(-c3ccc(O)c(OC)c3)n2n1
Show InChI InChI=1S/C21H19N3O4/c1-26-18-8-5-13(10-20(18)28-3)15-6-9-21-22-12-16(24(21)23-15)14-4-7-17(25)19(11-14)27-2/h4-12,25H,1-3H3
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US Patent


Assay Description
The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...


US Patent US10688093 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM447061
PNG
(4-[6-(3,4- dimethoxyphenyl) imidazo[1,2- b]pyridaz...)
Show SMILES COc1ccc(cc1OC)-c1ccc2ncc(-c3ccc(O)c(OC)c3)n2n1
Show InChI InChI=1S/C21H19N3O4/c1-26-18-8-5-13(10-20(18)28-3)15-6-9-21-22-12-16(24(21)23-15)14-4-7-17(25)19(11-14)27-2/h4-12,25H,1-3H3
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US Patent


Assay Description
The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...


US Patent US10688093 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM447377
PNG
(US10688093, Compound BF000707279)
Show SMILES COc1cc(ccc1O)-c1cc(cnc1N)-c1ccc(cc1)N1CCNCC1
Show InChI InChI=1S/C22H24N4O2/c1-28-21-13-16(4-7-20(21)27)19-12-17(14-25-22(19)23)15-2-5-18(6-3-15)26-10-8-24-9-11-26/h2-7,12-14,24,27H,8-11H2,1H3,(H2,23,25)
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US Patent


Assay Description
The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...


US Patent US10688093 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM447112
PNG
(4-[6-[4- (hydroxymethyl) phenyl]imidazo [1,2-b]pyr...)
Show SMILES COc1cc(ccc1O)-c1cnc2ccc(nn12)-c1ccc(CO)cc1
Show InChI InChI=1S/C20H17N3O3/c1-26-19-10-15(6-8-18(19)25)17-11-21-20-9-7-16(22-23(17)20)14-4-2-13(12-24)3-5-14/h2-11,24-25H,12H2,1H3
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US Patent


Assay Description
The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...


US Patent US10688093 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM447125
PNG
(4-[6-[3- (hydroxymethyl) phenyl]imidazo [1,2-b]pyr...)
Show SMILES COc1cc(ccc1O)-c1cnc2ccc(nn12)-c1cccc(CO)c1
Show InChI InChI=1S/C20H17N3O3/c1-26-19-10-15(5-7-18(19)25)17-11-21-20-8-6-16(22-23(17)20)14-4-2-3-13(9-14)12-24/h2-11,24-25H,12H2,1H3
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US Patent


Assay Description
The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...


US Patent US10688093 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM447400
PNG
(US10688093, Compound BF000817185)
Show SMILES COc1cc(ccc1O)-c1cc(cnc1N)-c1ccc(cc1)N1CCN(CC1)C(C)C
Show InChI InChI=1S/C25H30N4O2/c1-17(2)28-10-12-29(13-11-28)21-7-4-18(5-8-21)20-14-22(25(26)27-16-20)19-6-9-23(30)24(15-19)31-3/h4-9,14-17,30H,10-13H2,1-3H3,(H2,26,27)
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US Patent


Assay Description
The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...


US Patent US10688093 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM447397
PNG
(US10688093, Compound BF000817169)
Show SMILES COc1cc(ccc1O)-c1cnc2ccc(nn12)-c1ccncc1
Show InChI InChI=1S/C18H14N4O2/c1-24-17-10-13(2-4-16(17)23)15-11-20-18-5-3-14(21-22(15)18)12-6-8-19-9-7-12/h2-11,23H,1H3
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US Patent


Assay Description
The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...


US Patent US10688093 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM50309188
PNG
(4-(2-amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl)...)
Show SMILES COc1cc(ccc1O)-c1cc(cnc1N)-c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C21H22N2O5/c1-25-17-8-12(5-6-16(17)24)15-7-14(11-23-21(15)22)13-9-18(26-2)20(28-4)19(10-13)27-3/h5-11,24H,1-4H3,(H2,22,23)
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US Patent


Assay Description
The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...


US Patent US10688093 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM447330
PNG
(US10688093, Compound BF000147080)
Show SMILES CCCNc1ccc2ncc(-c3ccc(O)c(OC)c3)n2n1
Show InChI InChI=1S/C16H18N4O2/c1-3-8-17-15-6-7-16-18-10-12(20(16)19-15)11-4-5-13(21)14(9-11)22-2/h4-7,9-10,21H,3,8H2,1-2H3,(H,17,19)
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US Patent


Assay Description
The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...


US Patent US10688093 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM447399
PNG
(US10688093, Compound BF000817175)
Show SMILES COc1cc(cc(OC)c1OC)-c1cnc(N)c(c1)-c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C23H26N2O6/c1-26-17-8-13(9-18(27-2)21(17)30-5)15-7-16(23(24)25-12-15)14-10-19(28-3)22(31-6)20(11-14)29-4/h7-12H,1-6H3,(H2,24,25)
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US Patent


Assay Description
The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...


US Patent US10688093 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM447035
PNG
(N-[3-[6-(4- hydroxy-3- methoxy- phenyl)imidazo [1,...)
Show SMILES COc1cc(ccc1O)-c1ccc2ncc(-c3cccc(NC(C)=O)c3)n2n1
Show InChI InChI=1S/C21H18N4O3/c1-13(26)23-16-5-3-4-15(10-16)18-12-22-21-9-7-17(24-25(18)21)14-6-8-19(27)20(11-14)28-2/h3-12,27H,1-2H3,(H,23,26)
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US Patent


Assay Description
The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...


US Patent US10688093 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM446997
PNG
(N-[3-[3-(4- hydroxy-3- methoxy- phenyl)imidazo [1,...)
Show SMILES COc1cc(ccc1O)-c1cnc2ccc(nn12)-c1cccc(NC(C)=O)c1
Show InChI InChI=1S/C21H18N4O3/c1-13(26)23-16-5-3-4-14(10-16)17-7-9-21-22-12-18(25(21)24-17)15-6-8-19(27)20(11-15)28-2/h3-12,27H,1-2H3,(H,23,26)
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US Patent


Assay Description
The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...


US Patent US10688093 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM447125
PNG
(4-[6-[3- (hydroxymethyl) phenyl]imidazo [1,2-b]pyr...)
Show SMILES COc1cc(ccc1O)-c1cnc2ccc(nn12)-c1cccc(CO)c1
Show InChI InChI=1S/C20H17N3O3/c1-26-19-10-15(5-7-18(19)25)17-11-21-20-8-6-16(22-23(17)20)14-4-2-3-13(9-14)12-24/h2-11,24-25H,12H2,1H3
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US Patent


Assay Description
The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...


US Patent US10688093 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM446997
PNG
(N-[3-[3-(4- hydroxy-3- methoxy- phenyl)imidazo [1,...)
Show SMILES COc1cc(ccc1O)-c1cnc2ccc(nn12)-c1cccc(NC(C)=O)c1
Show InChI InChI=1S/C21H18N4O3/c1-13(26)23-16-5-3-4-14(10-16)17-7-9-21-22-12-18(25(21)24-17)15-6-8-19(27)20(11-15)28-2/h3-12,27H,1-2H3,(H,23,26)
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US Patent


Assay Description
The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...


US Patent US10688093 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM447331
PNG
(US10688093, Compound BF000145941)
Show SMILES C(Nc1ccc2ncc(-c3ccncc3)n2n1)c1cccs1
Show InChI InChI=1S/C16H13N5S/c1-2-13(22-9-1)10-18-15-3-4-16-19-11-14(21(16)20-15)12-5-7-17-8-6-12/h1-9,11H,10H2,(H,18,20)
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US Patent


Assay Description
The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...


US Patent US10688093 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM447332
PNG
(US10688093, Compound BF000147168)
Show SMILES COc1cc(ccc1O)-c1cnc2ccc(NC3CCOCC3)nn12
Show InChI InChI=1S/C18H20N4O3/c1-24-16-10-12(2-3-15(16)23)14-11-19-18-5-4-17(21-22(14)18)20-13-6-8-25-9-7-13/h2-5,10-11,13,23H,6-9H2,1H3,(H,20,21)
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US Patent


Assay Description
The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...


US Patent US10688093 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM50309188
PNG
(4-(2-amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl)...)
Show SMILES COc1cc(ccc1O)-c1cc(cnc1N)-c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C21H22N2O5/c1-25-17-8-12(5-6-16(17)24)15-7-14(11-23-21(15)22)13-9-18(26-2)20(28-4)19(10-13)27-3/h5-11,24H,1-4H3,(H2,22,23)
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US Patent


Assay Description
The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...


US Patent US10688093 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM447334
PNG
(US10688093, Compound BF000313028)
Show SMILES COc1cc(ccc1O)-c1cc(cnc1N)-c1ccc(cc1)N1CCN(C)CC1
Show InChI InChI=1S/C23H26N4O2/c1-26-9-11-27(12-10-26)19-6-3-16(4-7-19)18-13-20(23(24)25-15-18)17-5-8-21(28)22(14-17)29-2/h3-8,13-15,28H,9-12H2,1-2H3,(H2,24,25)
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Assay Description
The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...


US Patent US10688093 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM447112
PNG
(4-[6-[4- (hydroxymethyl) phenyl]imidazo [1,2-b]pyr...)
Show SMILES COc1cc(ccc1O)-c1cnc2ccc(nn12)-c1ccc(CO)cc1
Show InChI InChI=1S/C20H17N3O3/c1-26-19-10-15(6-8-18(19)25)17-11-21-20-9-7-16(22-23(17)20)14-4-2-13(12-24)3-5-14/h2-11,24-25H,12H2,1H3
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Assay Description
The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...


US Patent US10688093 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM447029
PNG
(4-[3-[3- (hydroxymethyl) phenyl]imidazo [1,2-b]pyr...)
Show SMILES COc1cc(ccc1O)-c1ccc2ncc(-c3cccc(CO)c3)n2n1
Show InChI InChI=1S/C20H17N3O3/c1-26-19-10-14(5-7-18(19)25)16-6-8-20-21-11-17(23(20)22-16)15-4-2-3-13(9-15)12-24/h2-11,24-25H,12H2,1H3
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Assay Description
The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...


US Patent US10688093 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM95242
PNG
(MLS003123272 | N-[2-(dimethylamino)ethyl]-4-[3-(4-...)
Show SMILES CN(C)CCNC(=O)c1ccc(cc1)-c1cn2c(cnc2cn1)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C29H27N5O2/c1-33(2)17-16-30-29(35)23-10-8-21(9-11-23)26-20-34-27(18-32-28(34)19-31-26)22-12-14-25(15-13-22)36-24-6-4-3-5-7-24/h3-15,18-20H,16-17H2,1-2H3,(H,30,35)
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Assay Description
The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...


US Patent US10688093 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM447335
PNG
(US10688093, Compound BF000145954)
Show SMILES COc1cc(ccc1O)-c1cnc2ccc(NCc3cccs3)nn12
Show InChI InChI=1S/C18H16N4O2S/c1-24-16-9-12(4-5-15(16)23)14-11-20-18-7-6-17(21-22(14)18)19-10-13-3-2-8-25-13/h2-9,11,23H,10H2,1H3,(H,19,21)
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Assay Description
The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...


US Patent US10688093 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM447035
PNG
(N-[3-[6-(4- hydroxy-3- methoxy- phenyl)imidazo [1,...)
Show SMILES COc1cc(ccc1O)-c1ccc2ncc(-c3cccc(NC(C)=O)c3)n2n1
Show InChI InChI=1S/C21H18N4O3/c1-13(26)23-16-5-3-4-15(10-16)18-12-22-21-9-7-17(24-25(18)21)14-6-8-19(27)20(11-14)28-2/h3-12,27H,1-2H3,(H,23,26)
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Assay Description
The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...


US Patent US10688093 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM446977
PNG
(N-[4-[3-(4- hydroxy-3- methoxy- phenyl)imidazo [1,...)
Show SMILES COc1cc(ccc1O)-c1cnc2ccc(nn12)-c1ccc(NC(C)=O)cc1
Show InChI InChI=1S/C21H18N4O3/c1-13(26)23-16-6-3-14(4-7-16)17-8-10-21-22-12-18(25(21)24-17)15-5-9-19(27)20(11-15)28-2/h3-12,27H,1-2H3,(H,23,26)
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Assay Description
The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...


US Patent US10688093 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM447398
PNG
(US10688093, Compound BF000817170)
Show SMILES C(Nc1ccc2ncc(-c3ccncc3)n2n1)c1ccccn1
Show InChI InChI=1S/C17H14N6/c1-2-8-19-14(3-1)11-20-16-4-5-17-21-12-15(23(17)22-16)13-6-9-18-10-7-13/h1-10,12H,11H2,(H,20,22)
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Assay Description
The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...


US Patent US10688093 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM447126
PNG
(1-[3-[6-[3- (hydroxymethyl) phenyl]imidazo [1,2-b]...)
Show SMILES CC(=O)c1cccc(c1)-c1cnc2ccc(nn12)-c1cccc(CO)c1
Show InChI InChI=1S/C21H17N3O2/c1-14(26)16-5-3-7-18(11-16)20-12-22-21-9-8-19(23-24(20)21)17-6-2-4-15(10-17)13-25/h2-12,25H,13H2,1H3
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Assay Description
The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...


US Patent US10688093 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM447155
PNG
(4-[6-(1,3- benzodioxol-5- yl)imidazo[1,2- b]pyrida...)
Show SMILES COc1cc(ccc1O)-c1cnc2ccc(nn12)-c1ccc2OCOc2c1
Show InChI InChI=1S/C20H15N3O4/c1-25-18-9-13(2-5-16(18)24)15-10-21-20-7-4-14(22-23(15)20)12-3-6-17-19(8-12)27-11-26-17/h2-10,24H,11H2,1H3
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Assay Description
The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...


US Patent US10688093 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM447087
PNG
(3-[6-(4- pyridyl)imidazo [1,2-b]pyridazin- 3-yl]ph...)
Show SMILES Oc1cccc(c1)-c1cnc2ccc(nn12)-c1ccncc1
Show InChI InChI=1S/C17H12N4O/c22-14-3-1-2-13(10-14)16-11-19-17-5-4-15(20-21(16)17)12-6-8-18-9-7-12/h1-11,22H
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Assay Description
The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...


US Patent US10688093 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM446750
PNG
(4-[6-(3- hydroxy- propylamino) imidazo[1,2- b]pyri...)
Show SMILES COc1cc(ccc1O)-c1cnc2ccc(NCCCO)nn12
Show InChI InChI=1S/C16H18N4O3/c1-23-14-9-11(3-4-13(14)22)12-10-18-16-6-5-15(19-20(12)16)17-7-2-8-21/h3-6,9-10,21-22H,2,7-8H2,1H3,(H,17,19)
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Assay Description
The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...


US Patent US10688093 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM50309193
PNG
(4-(2-amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl)...)
Show SMILES COc1cc(cc(OC)c1OC)-c1cnc(N)c(c1)-c1ccc(O)cc1
Show InChI InChI=1S/C20H20N2O4/c1-24-17-9-13(10-18(25-2)19(17)26-3)14-8-16(20(21)22-11-14)12-4-6-15(23)7-5-12/h4-11,23H,1-3H3,(H2,21,22)
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Assay Description
The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...


US Patent US10688093 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM447076
PNG
(N-[3-[6-(2- thienyl)imidazo [1,2-b]pyridazin- 3-yl...)
Show SMILES CC(=O)Nc1cccc(c1)-c1cnc2ccc(nn12)-c1cccs1
Show InChI InChI=1S/C18H14N4OS/c1-12(23)20-14-5-2-4-13(10-14)16-11-19-18-8-7-15(21-22(16)18)17-6-3-9-24-17/h2-11H,1H3,(H,20,23)
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Assay Description
The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...


US Patent US10688093 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM447146
PNG
(3-(3,4- dimethoxy- phenyl)-6-(2- thienyl)imidazo [...)
Show SMILES COc1ccc(cc1OC)-c1cnc2ccc(nn12)-c1cccs1
Show InChI InChI=1S/C18H15N3O2S/c1-22-15-7-5-12(10-16(15)23-2)14-11-19-18-8-6-13(20-21(14)18)17-4-3-9-24-17/h3-11H,1-2H3
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Assay Description
The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...


US Patent US10688093 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM447405
PNG
(US10688093, Compound BF000817413)
Show SMILES COc1cc(ccc1O)-c1cc(cnc1N)-c1ccc(cc1)N1CCOCC1
Show InChI InChI=1S/C22H23N3O3/c1-27-21-13-16(4-7-20(21)26)19-12-17(14-24-22(19)23)15-2-5-18(6-3-15)25-8-10-28-11-9-25/h2-7,12-14,26H,8-11H2,1H3,(H2,23,24)
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Assay Description
The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...


US Patent US10688093 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM447338
PNG
(US10688093, Compound BF000313038)
Show SMILES COc1cc(ccc1O)-c1cc(cnc1N)-c1ccc(cc1)C(N)=O
Show InChI InChI=1S/C19H17N3O3/c1-25-17-9-13(6-7-16(17)23)15-8-14(10-22-18(15)20)11-2-4-12(5-3-11)19(21)24/h2-10,23H,1H3,(H2,20,22)(H2,21,24)
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Assay Description
The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...


US Patent US10688093 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM447290
PNG
(N-benzyl-5-(5- methoxy-3- pyridyl)imidazo [2,1-b][...)
Show SMILES COc1cncc(c1)-c1cnc2sc(NCc3ccccc3)nn12
Show InChI InChI=1S/C17H15N5OS/c1-23-14-7-13(9-18-10-14)15-11-20-17-22(15)21-16(24-17)19-8-12-5-3-2-4-6-12/h2-7,9-11H,8H2,1H3,(H,19,21)
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Assay Description
The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...


US Patent US10688093 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM447050
PNG
(6-(1,3- benzodioxol-5- yl)-3-(4- pyridyl)imidazo [...)
Show SMILES C1Oc2ccc(cc2O1)-c1ccc2ncc(-c3ccncc3)n2n1
Show InChI InChI=1S/C18H12N4O2/c1-3-16-17(24-11-23-16)9-13(1)14-2-4-18-20-10-15(22(18)21-14)12-5-7-19-8-6-12/h1-10H,11H2
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Assay Description
The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...


US Patent US10688093 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM447339
PNG
(10 | US10688093, Compound BF000147056)
Show SMILES CCCNc1ccc2ncc(-c3ccncc3)n2n1
Show InChI InChI=1S/C14H15N5/c1-2-7-16-13-3-4-14-17-10-12(19(14)18-13)11-5-8-15-9-6-11/h3-6,8-10H,2,7H2,1H3,(H,16,18)
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Assay Description
The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...


US Patent US10688093 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM447071
PNG
(2-methoxy-4-[6- (3-methoxyphenyl) imidazo[1,2- b]p...)
Show SMILES COc1cccc(c1)-c1ccc2ncc(-c3ccc(O)c(OC)c3)n2n1
Show InChI InChI=1S/C20H17N3O3/c1-25-15-5-3-4-13(10-15)16-7-9-20-21-12-17(23(20)22-16)14-6-8-18(24)19(11-14)26-2/h3-12,24H,1-2H3
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Assay Description
The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...


US Patent US10688093 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM95242
PNG
(MLS003123272 | N-[2-(dimethylamino)ethyl]-4-[3-(4-...)
Show SMILES CN(C)CCNC(=O)c1ccc(cc1)-c1cn2c(cnc2cn1)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C29H27N5O2/c1-33(2)17-16-30-29(35)23-10-8-21(9-11-23)26-20-34-27(18-32-28(34)19-31-26)22-12-14-25(15-13-22)36-24-6-4-3-5-7-24/h3-15,18-20H,16-17H2,1-2H3,(H,30,35)
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Assay Description
The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...


US Patent US10688093 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM447025
PNG
(4-[3-(3,4- dimethoxy- phenyl)imidazo [1,2-b]pyrida...)
Show SMILES COc1ccc(cc1OC)-c1cnc2ccc(nn12)-c1ccc(O)c(OC)c1
Show InChI InChI=1S/C21H19N3O4/c1-26-18-8-5-14(11-20(18)28-3)16-12-22-21-9-6-15(23-24(16)21)13-4-7-17(25)19(10-13)27-2/h4-12,25H,1-3H3
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Assay Description
The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...


US Patent US10688093 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM446987
PNG
(4-[3-(3- acetamidophenyl) imidazo[1,2- b]pyridazin...)
Show SMILES CC(=O)Nc1cccc(c1)-c1cnc2ccc(nn12)-c1ccc(cc1)C(N)=O
Show InChI InChI=1S/C21H17N5O2/c1-13(27)24-17-4-2-3-16(11-17)19-12-23-20-10-9-18(25-26(19)20)14-5-7-15(8-6-14)21(22)28/h2-12H,1H3,(H2,22,28)(H,24,27)
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Assay Description
The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...


US Patent US10688093 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM447031
PNG
(3-[3-(4- pyridyl)imidazo [1,2-b]pyridazin- 6-yl]ph...)
Show SMILES Oc1cccc(c1)-c1ccc2ncc(-c3ccncc3)n2n1
Show InChI InChI=1S/C17H12N4O/c22-14-3-1-2-13(10-14)15-4-5-17-19-11-16(21(17)20-15)12-6-8-18-9-7-12/h1-11,22H
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US Patent


Assay Description
The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...


US Patent US10688093 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM447004
PNG
(4-[3-[4- (hydroxymethyl) phenyl]imidazo [1,2-b]pyr...)
Show SMILES COc1cc(ccc1O)-c1ccc2ncc(-c3ccc(CO)cc3)n2n1
Show InChI InChI=1S/C20H17N3O3/c1-26-19-10-15(6-8-18(19)25)16-7-9-20-21-11-17(23(20)22-16)14-4-2-13(12-24)3-5-14/h2-11,24-25H,12H2,1H3
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US Patent


Assay Description
The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...


US Patent US10688093 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM447181
PNG
(3-[3-(4-hydroxy- 3-methoxy- phenyl)imidazo [1,2-b]...)
Show SMILES COc1cc(ccc1O)-c1cnc2ccc(nn12)-c1cccc(c1)C(N)=O
Show InChI InChI=1S/C20H16N4O3/c1-27-18-10-13(5-7-17(18)25)16-11-22-19-8-6-15(23-24(16)19)12-3-2-4-14(9-12)20(21)26/h2-11,25H,1H3,(H2,21,26)
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US Patent


Assay Description
The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...


US Patent US10688093 (2020)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%