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Patent code US10689327

Compile Data Set for Download or QSAR
Found 30 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM446832
PNG
((1R,2R,3R,5R,6R)-2-amino-6-fluoro-3-[(2-oxo-1,2- d...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1cc[nH]c(=O)c1)[C@]2(F)C(O)=O)C(O)=O
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n/an/a 4.35n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37 C. under 5% CO2 using a Dulbecco's modi...


US Patent US10689327 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM446712
PNG
((1R,2R,3R,5R,6R)-2-amino-6-fluoro-3-[(1R)-1-(4- fl...)
Show SMILES COc1cc(ccc1F)[C@@H](C)O[C@@H]1C[C@@H]2[C@@H]([C@@]2(F)C(O)=O)[C@]1(N)C(O)=O
Show InChI InChI=1S/C17H19F2NO6/c1-7(8-3-4-10(18)11(5-8)25-2)26-12-6-9-13(16(9,19)14(21)22)17(12,20)15(23)24/h3-5,7,9,12-13H,6,20H2,1-2H3,(H,21,22)(H,23,24)/t7-,9-,12-,13+,16-,17+/m1/s1
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n/an/a 5.04n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37 C. under 5% CO2 using a Dulbecco's modi...


US Patent US10689327 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM446712
PNG
((1R,2R,3R,5R,6R)-2-amino-6-fluoro-3-[(1R)-1-(4- fl...)
Show SMILES COc1cc(ccc1F)[C@@H](C)O[C@@H]1C[C@@H]2[C@@H]([C@@]2(F)C(O)=O)[C@]1(N)C(O)=O
Show InChI InChI=1S/C17H19F2NO6/c1-7(8-3-4-10(18)11(5-8)25-2)26-12-6-9-13(16(9,19)14(21)22)17(12,20)15(23)24/h3-5,7,9,12-13H,6,20H2,1-2H3,(H,21,22)(H,23,24)/t7-,9-,12-,13+,16-,17+/m1/s1
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n/an/a 5.22n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37 C. under 5% CO2 using a Dulbecco's modi...


US Patent US10689327 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM446818
PNG
((1R,2R,3R,5R,6R)-2-amino-3-[(5-chloropyridin-2- yl...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1ccc(Cl)cn1)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H14ClFN2O5/c15-6-1-2-7(18-4-6)5-23-9-3-8-10(13(8,16)11(19)20)14(9,17)12(21)22/h1-2,4,8-10H,3,5,17H2,(H,19,20)(H,21,22)/t8-,9-,10+,13-,14+/m1/s1
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n/an/a 12.4n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37 C. under 5% CO2 using a Dulbecco's modi...


US Patent US10689327 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM446701
PNG
(US10689327, Compound (II)-2)
Show SMILES OC(=O)[C@@]1(F)[C@@H]2C[C@@H](OCc3ccc(F)c(F)c3)[C@](NC(=O)OCC=C)([C@H]12)C(O)=O
Show InChI InChI=1S/C19H18F3NO7/c1-2-5-29-17(28)23-19(16(26)27)13(7-10-14(19)18(10,22)15(24)25)30-8-9-3-4-11(20)12(21)6-9/h2-4,6,10,13-14H,1,5,7-8H2,(H,23,28)(H,24,25)(H,26,27)/t10-,13-,14+,18-,19+/m1/s1
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n/an/a 14.8n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37 C. under 5% CO2 using a Dulbecco's modi...


US Patent US10689327 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM446836
PNG
((1S,2R,3R,5R,6S)-2-amino-3-[(3,4- difluorophenyl)m...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1ccc(F)c(F)c1)[C@@H]2C(O)=O)C(O)=O
Show InChI InChI=1S/C15H15F2NO5/c16-8-2-1-6(3-9(8)17)5-23-10-4-7-11(13(19)20)12(7)15(10,18)14(21)22/h1-3,7,10-12H,4-5,18H2,(H,19,20)(H,21,22)/t7-,10+,11-,12-,15-/m0/s1
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n/an/a 15.2n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37 C. under 5% CO2 using a Dulbecco's modi...


US Patent US10689327 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM446784
PNG
((1R,2R,3R,5R,6R)-2-amino-3-[(6-chloropyridin-2- yl...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1cccc(Cl)n1)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H14ClFN2O5/c15-9-3-1-2-6(18-9)5-23-8-4-7-10(13(7,16)11(19)20)14(8,17)12(21)22/h1-3,7-8,10H,4-5,17H2,(H,19,20)(H,21,22)/t7-,8-,10+,13-,14+/m1/s1
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n/an/a 18.6n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37 C. under 5% CO2 using a Dulbecco's modi...


US Patent US10689327 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM446701
PNG
(US10689327, Compound (II)-2)
Show SMILES OC(=O)[C@@]1(F)[C@@H]2C[C@@H](OCc3ccc(F)c(F)c3)[C@](NC(=O)OCC=C)([C@H]12)C(O)=O
Show InChI InChI=1S/C19H18F3NO7/c1-2-5-29-17(28)23-19(16(26)27)13(7-10-14(19)18(10,22)15(24)25)30-8-9-3-4-11(20)12(21)6-9/h2-4,6,10,13-14H,1,5,7-8H2,(H,23,28)(H,24,25)(H,26,27)/t10-,13-,14+,18-,19+/m1/s1
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n/an/a 18.8n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37 C. under 5% CO2 using a Dulbecco's modi...


US Patent US10689327 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM446718
PNG
((1R,2R,3R,5R,6R)-2-amino-6-fluoro-3-{[4- (triflour...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1ccc(cc1)C(F)(F)F)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C16H15F4NO5/c17-14(12(22)23)9-5-10(15(21,11(9)14)13(24)25)26-6-7-1-3-8(4-2-7)16(18,19)20/h1-4,9-11H,5-6,21H2,(H,22,23)(H,24,25)/t9-,10-,11+,14-,15+/m1/s1
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n/an/a 23.7n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37 C. under 5% CO2 using a Dulbecco's modi...


US Patent US10689327 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM446828
PNG
((1R,2R,3R,5R,6R)-2-amino-6-fluoro-3-[(4- methylphe...)
Show SMILES Cc1ccc(CO[C@@H]2C[C@@H]3[C@@H]([C@@]3(F)C(O)=O)[C@]2(N)C(O)=O)cc1
Show InChI InChI=1S/C16H18FNO5/c1-8-2-4-9(5-3-8)7-23-11-6-10-12(15(10,17)13(19)20)16(11,18)14(21)22/h2-5,10-12H,6-7,18H2,1H3,(H,19,20)(H,21,22)/t10-,11-,12+,15-,16+/m1/s1
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n/an/a 24.6n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37 C. under 5% CO2 using a Dulbecco's modi...


US Patent US10689327 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM446739
PNG
((1R,2R,3R,5R,6R)-2-amino-6-fluoro-3-[(3- fluorophe...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1cccc(F)c1)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H15F2NO5/c16-8-3-1-2-7(4-8)6-23-10-5-9-11(14(9,17)12(19)20)15(10,18)13(21)22/h1-4,9-11H,5-6,18H2,(H,19,20)(H,21,22)/t9-,10-,11+,14-,15+/m1/s1
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n/an/a 27.8n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37 C. under 5% CO2 using a Dulbecco's modi...


US Patent US10689327 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM446818
PNG
((1R,2R,3R,5R,6R)-2-amino-3-[(5-chloropyridin-2- yl...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1ccc(Cl)cn1)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H14ClFN2O5/c15-6-1-2-7(18-4-6)5-23-9-3-8-10(13(8,16)11(19)20)14(9,17)12(21)22/h1-2,4,8-10H,3,5,17H2,(H,19,20)(H,21,22)/t8-,9-,10+,13-,14+/m1/s1
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n/an/a 28.4n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37 C. under 5% CO2 using a Dulbecco's modi...


US Patent US10689327 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM446836
PNG
((1S,2R,3R,5R,6S)-2-amino-3-[(3,4- difluorophenyl)m...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1ccc(F)c(F)c1)[C@@H]2C(O)=O)C(O)=O
Show InChI InChI=1S/C15H15F2NO5/c16-8-2-1-6(3-9(8)17)5-23-10-4-7-11(13(19)20)12(7)15(10,18)14(21)22/h1-3,7,10-12H,4-5,18H2,(H,19,20)(H,21,22)/t7-,10+,11-,12-,15-/m0/s1
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n/an/a 30.1n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37 C. under 5% CO2 using a Dulbecco's modi...


US Patent US10689327 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM446784
PNG
((1R,2R,3R,5R,6R)-2-amino-3-[(6-chloropyridin-2- yl...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1cccc(Cl)n1)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H14ClFN2O5/c15-9-3-1-2-6(18-9)5-23-8-4-7-10(13(7,16)11(19)20)14(8,17)12(21)22/h1-3,7-8,10H,4-5,17H2,(H,19,20)(H,21,22)/t7-,8-,10+,13-,14+/m1/s1
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n/an/a 32.3n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37 C. under 5% CO2 using a Dulbecco's modi...


US Patent US10689327 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM446857
PNG
(US10689327, Compound (II)-15)
Show SMILES CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)O[C@H](C)OC(=O)[C@@]1(N)[C@H]2[C@@H](C[C@H]1OCc1ccc(F)cc1)[C@@H]2C(O)=O
Show InChI InChI=1S/C28H38FNO8/c1-14(2)19-10-5-15(3)11-21(19)38-27(34)37-16(4)36-26(33)28(30)22(12-20-23(24(20)28)25(31)32)35-13-17-6-8-18(29)9-7-17/h6-9,14-16,19-24H,5,10-13,30H2,1-4H3,(H,31,32)/t15-,16-,19+,20+,21-,22-,23+,24+,28+/m1/s1
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n/an/a 32.7n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37 C. under 5% CO2 using a Dulbecco's modi...


US Patent US10689327 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM446699
PNG
(US10689327, Compound (II)-1)
Show SMILES OC(=O)[C@@]1(F)[C@@H]2C[C@@H](OCc3ccc(F)cc3)[C@](NC(=O)OCC=C)([C@H]12)C(O)=O
Show InChI InChI=1S/C19H19F2NO7/c1-2-7-28-17(27)22-19(16(25)26)13(8-12-14(19)18(12,21)15(23)24)29-9-10-3-5-11(20)6-4-10/h2-6,12-14H,1,7-9H2,(H,22,27)(H,23,24)(H,25,26)/t12-,13-,14+,18-,19+/m1/s1
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n/an/a 36.1n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37 C. under 5% CO2 using a Dulbecco's modi...


US Patent US10689327 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM446699
PNG
(US10689327, Compound (II)-1)
Show SMILES OC(=O)[C@@]1(F)[C@@H]2C[C@@H](OCc3ccc(F)cc3)[C@](NC(=O)OCC=C)([C@H]12)C(O)=O
Show InChI InChI=1S/C19H19F2NO7/c1-2-7-28-17(27)22-19(16(25)26)13(8-12-14(19)18(12,21)15(23)24)29-9-10-3-5-11(20)6-4-10/h2-6,12-14H,1,7-9H2,(H,22,27)(H,23,24)(H,25,26)/t12-,13-,14+,18-,19+/m1/s1
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n/an/a 36.4n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37 C. under 5% CO2 using a Dulbecco's modi...


US Patent US10689327 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM446832
PNG
((1R,2R,3R,5R,6R)-2-amino-6-fluoro-3-[(2-oxo-1,2- d...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1cc[nH]c(=O)c1)[C@]2(F)C(O)=O)C(O)=O
PDB

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n/an/a 37.3n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37 C. under 5% CO2 using a Dulbecco's modi...


US Patent US10689327 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM446817
PNG
((1R,2R,3R,5R,6R)-2-amino-3-[(6-chloropyridin-3- yl...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1ccc(Cl)nc1)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H14ClFN2O5/c15-9-2-1-6(4-18-9)5-23-8-3-7-10(13(7,16)11(19)20)14(8,17)12(21)22/h1-2,4,7-8,10H,3,5,17H2,(H,19,20)(H,21,22)/t7-,8-,10+,13-,14+/m1/s1
PDB

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n/an/a 49.7n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37 C. under 5% CO2 using a Dulbecco's modi...


US Patent US10689327 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM446817
PNG
((1R,2R,3R,5R,6R)-2-amino-3-[(6-chloropyridin-3- yl...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1ccc(Cl)nc1)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H14ClFN2O5/c15-9-2-1-6(4-18-9)5-23-8-3-7-10(13(7,16)11(19)20)14(8,17)12(21)22/h1-2,4,7-8,10H,3,5,17H2,(H,19,20)(H,21,22)/t7-,8-,10+,13-,14+/m1/s1
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n/an/a 50.6n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37 C. under 5% CO2 using a Dulbecco's modi...


US Patent US10689327 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM446828
PNG
((1R,2R,3R,5R,6R)-2-amino-6-fluoro-3-[(4- methylphe...)
Show SMILES Cc1ccc(CO[C@@H]2C[C@@H]3[C@@H]([C@@]3(F)C(O)=O)[C@]2(N)C(O)=O)cc1
Show InChI InChI=1S/C16H18FNO5/c1-8-2-4-9(5-3-8)7-23-11-6-10-12(15(10,17)13(19)20)16(11,18)14(21)22/h2-5,10-12H,6-7,18H2,1H3,(H,19,20)(H,21,22)/t10-,11-,12+,15-,16+/m1/s1
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n/an/a 54.4n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37 C. under 5% CO2 using a Dulbecco's modi...


US Patent US10689327 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM446857
PNG
(US10689327, Compound (II)-15)
Show SMILES CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)O[C@H](C)OC(=O)[C@@]1(N)[C@H]2[C@@H](C[C@H]1OCc1ccc(F)cc1)[C@@H]2C(O)=O
Show InChI InChI=1S/C28H38FNO8/c1-14(2)19-10-5-15(3)11-21(19)38-27(34)37-16(4)36-26(33)28(30)22(12-20-23(24(20)28)25(31)32)35-13-17-6-8-18(29)9-7-17/h6-9,14-16,19-24H,5,10-13,30H2,1-4H3,(H,31,32)/t15-,16-,19+,20+,21-,22-,23+,24+,28+/m1/s1
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n/an/a 60.5n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37 C. under 5% CO2 using a Dulbecco's modi...


US Patent US10689327 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50151462
PNG
((1R,2R,3R,5R,6R)-2-Amino-3-cyclopentyloxy-6-fluoro...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OC1CCCC1)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C13H18FNO5/c14-12(10(16)17)7-5-8(20-6-3-1-2-4-6)13(15,9(7)12)11(18)19/h6-9H,1-5,15H2,(H,16,17)(H,18,19)/t7-,8-,9+,12-,13+/m1/s1
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n/an/a 62.2n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37 C. under 5% CO2 using a Dulbecco's modi...


US Patent US10689327 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM446702
PNG
(US10689327, Compound (II)-3)
Show SMILES CCCO[C@@H]1C[C@@H]2[C@@H]([C@@]2(F)C(O)=O)[C@]1(NC(=O)OCC=C)C(O)=O
Show InChI InChI=1S/C15H20FNO7/c1-3-5-23-9-7-8-10(14(8,16)11(18)19)15(9,12(20)21)17-13(22)24-6-4-2/h4,8-10H,2-3,5-7H2,1H3,(H,17,22)(H,18,19)(H,20,21)/t8-,9-,10+,14-,15+/m1/s1
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n/an/a 75.1n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37 C. under 5% CO2 using a Dulbecco's modi...


US Patent US10689327 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM446739
PNG
((1R,2R,3R,5R,6R)-2-amino-6-fluoro-3-[(3- fluorophe...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1cccc(F)c1)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H15F2NO5/c16-8-3-1-2-7(4-8)6-23-10-5-9-11(14(9,17)12(19)20)15(10,18)13(21)22/h1-4,9-11H,5-6,18H2,(H,19,20)(H,21,22)/t9-,10-,11+,14-,15+/m1/s1
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n/an/a 75.5n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37 C. under 5% CO2 using a Dulbecco's modi...


US Patent US10689327 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM50151462
PNG
((1R,2R,3R,5R,6R)-2-Amino-3-cyclopentyloxy-6-fluoro...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OC1CCCC1)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C13H18FNO5/c14-12(10(16)17)7-5-8(20-6-3-1-2-4-6)13(15,9(7)12)11(18)19/h6-9H,1-5,15H2,(H,16,17)(H,18,19)/t7-,8-,9+,12-,13+/m1/s1
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n/an/a 97.6n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37 C. under 5% CO2 using a Dulbecco's modi...


US Patent US10689327 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM446756
PNG
((1R,2R,3R,5R,6R)-2-amino-6-fluoro-3-(3- methylbuto...)
Show SMILES CC(C)CCO[C@@H]1C[C@@H]2[C@@H]([C@@]2(F)C(O)=O)[C@]1(N)C(O)=O
Show InChI InChI=1S/C13H20FNO5/c1-6(2)3-4-20-8-5-7-9(12(7,14)10(16)17)13(8,15)11(18)19/h6-9H,3-5,15H2,1-2H3,(H,16,17)(H,18,19)/t7-,8-,9+,12-,13+/m1/s1
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n/an/a 98.8n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37 C. under 5% CO2 using a Dulbecco's modi...


US Patent US10689327 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM446756
PNG
((1R,2R,3R,5R,6R)-2-amino-6-fluoro-3-(3- methylbuto...)
Show SMILES CC(C)CCO[C@@H]1C[C@@H]2[C@@H]([C@@]2(F)C(O)=O)[C@]1(N)C(O)=O
Show InChI InChI=1S/C13H20FNO5/c1-6(2)3-4-20-8-5-7-9(12(7,14)10(16)17)13(8,15)11(18)19/h6-9H,3-5,15H2,1-2H3,(H,16,17)(H,18,19)/t7-,8-,9+,12-,13+/m1/s1
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n/an/a 173n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37 C. under 5% CO2 using a Dulbecco's modi...


US Patent US10689327 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM446718
PNG
((1R,2R,3R,5R,6R)-2-amino-6-fluoro-3-{[4- (triflour...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1ccc(cc1)C(F)(F)F)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C16H15F4NO5/c17-14(12(22)23)9-5-10(15(21,11(9)14)13(24)25)26-6-7-1-3-8(4-2-7)16(18,19)20/h1-4,9-11H,5-6,21H2,(H,22,23)(H,24,25)/t9-,10-,11+,14-,15+/m1/s1
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n/an/a 279n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37 C. under 5% CO2 using a Dulbecco's modi...


US Patent US10689327 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM446702
PNG
(US10689327, Compound (II)-3)
Show SMILES CCCO[C@@H]1C[C@@H]2[C@@H]([C@@]2(F)C(O)=O)[C@]1(NC(=O)OCC=C)C(O)=O
Show InChI InChI=1S/C15H20FNO7/c1-3-5-23-9-7-8-10(14(8,16)11(18)19)15(9,12(20)21)17-13(22)24-6-4-2/h4,8-10H,2-3,5-7H2,1H3,(H,17,22)(H,18,19)(H,20,21)/t8-,9-,10+,14-,15+/m1/s1
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n/an/a 321n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37 C. under 5% CO2 using a Dulbecco's modi...


US Patent US10689327 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%