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Patent code US10689345

Compile Data Set for Download or QSAR

Found 273 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404425
PNG
((R)-N-(1-cyanopyrrolidin-3-yl)-2- fluoro-4-(1-meth...)
Show SMILES Cn1cc(cn1)-c1ccc(C(=O)N[C@@H]2CCN(C2)C#N)c(F)c1
Show InChI InChI=1S/C16H16FN5O/c1-21-8-12(7-19-21)11-2-3-14(15(17)6-11)16(23)20-13-4-5-22(9-13)10-18/h2-3,6-8,13H,4-5,9H2,1H3,(H,20,23)/t13-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...


US Patent US10689345 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404428
PNG
((R)-N-(1-cyanopyrrolidin-3-yl)-4- (1,3-dimethyl-1H...)
Show SMILES Cc1nn(C)cc1-c1ccc(C(=O)N[C@@H]2CCN(C2)C#N)c(F)c1
Show InChI InChI=1S/C17H18FN5O/c1-11-15(9-22(2)21-11)12-3-4-14(16(18)7-12)17(24)20-13-5-6-23(8-13)10-19/h3-4,7,9,13H,5-6,8H2,1-2H3,(H,20,24)/t13-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...


US Patent US10689345 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404433
PNG
((R)-N-(1-cyanopyrrolidin-3-yl)-2- fluoro-4-(5-(tri...)
Show SMILES Fc1cc(ccc1C(=O)N[C@@H]1CCN(C1)C#N)-c1cn[nH]c1C(F)(F)F
Show InChI InChI=1S/C16H13F4N5O/c17-13-5-9(12-6-22-24-14(12)16(18,19)20)1-2-11(13)15(26)23-10-3-4-25(7-10)8-21/h1-2,5-6,10H,3-4,7H2,(H,22,24)(H,23,26)/t10-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...


US Patent US10689345 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM447579
PNG
((R)-N-(1-cyanopyrrolidin- 3-yl)-2-fluoro-4-(imidaz...)
Show SMILES Fc1cccc(c1)-c1ccc2c(cnn2c1)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C19H16FN5O/c20-15-3-1-2-13(8-15)14-4-5-18-17(9-22-25(18)10-14)19(26)23-16-6-7-24(11-16)12-21/h1-5,8-10,16H,6-7,11H2,(H,23,26)/t16-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...


US Patent US10689345 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM447580
PNG
((R)-N-(1-cyanopyrrolidin- 3-yl)-2-fluoro-4-(2-morp...)
Show SMILES Fc1cc(ccc1-c1ccc2c(cnn2c1)C(=O)N[C@@H]1CCN(C1)C#N)-c1ccnc(c1)N1CCCCC1
Show InChI InChI=1S/C29H28FN7O/c30-26-14-20(21-8-10-32-28(15-21)36-11-2-1-3-12-36)4-6-24(26)22-5-7-27-25(16-33-37(27)17-22)29(38)34-23-9-13-35(18-23)19-31/h4-8,10,14-17,23H,1-3,9,11-13,18H2,(H,34,38)/t23-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...


US Patent US10689345 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404491
PNG
((R)-N-(1-cyanopyrrolidin- 3-yl)-2-fluoro-4-(pyrrol...)
Show SMILES Fc1cc(ccc1C(=O)N[C@@H]1CCN(C1)C#N)N1CCCC1
Show InChI InChI=1S/C16H19FN4O/c17-15-9-13(21-6-1-2-7-21)3-4-14(15)16(22)19-12-5-8-20(10-12)11-18/h3-4,9,12H,1-2,5-8,10H2,(H,19,22)/t12-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...


US Patent US10689345 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404503
PNG
((R)-N-(1-cyanopyrrolidin-3-yl)-1-(cyclopropylmethy...)
Show SMILES Cc1noc(C)c1-c1ccc2c(nn(CC3CC3)c2c1)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C22H24N6O2/c1-13-20(14(2)30-26-13)16-5-6-18-19(9-16)28(10-15-3-4-15)25-21(18)22(29)24-17-7-8-27(11-17)12-23/h5-6,9,15,17H,3-4,7-8,10-11H2,1-2H3,(H,24,29)/t17-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...


US Patent US10689345 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404515
PNG
((R)-6-(3-cyanophenyl)-N-(1-cyanopyrrolidin-3-yl)-3...)
Show SMILES Fc1c(nc2ccc(cn12)-c1cccc(c1)C#N)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C20H15FN6O/c21-19-18(20(28)24-16-6-7-26(11-16)12-23)25-17-5-4-15(10-27(17)19)14-3-1-2-13(8-14)9-22/h1-5,8,10,16H,6-7,11H2,(H,24,28)/t16-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...


US Patent US10689345 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404540
PNG
((R)-3-(3-chlorophenyl)-N-(1-cyanopyrrolidin-3-yl)a...)
Show SMILES Clc1cccc(c1)C1CN(C1)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C15H17ClN4O/c16-13-3-1-2-11(6-13)12-7-20(8-12)15(21)18-14-4-5-19(9-14)10-17/h1-3,6,12,14H,4-5,7-9H2,(H,18,21)/t14-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...


US Patent US10689345 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404580
PNG
((R)-N-(1-cyanopyrrolidin-3-yl)-3-fluoro-1-methyl-5...)
Show SMILES Cn1cc(cn1)-c1ccc2n(C)c(C(=O)N[C@@H]3CCN(C3)C#N)c(F)c2c1
Show InChI InChI=1S/C19H19FN6O/c1-24-9-13(8-22-24)12-3-4-16-15(7-12)17(20)18(25(16)2)19(27)23-14-5-6-26(10-14)11-21/h3-4,7-9,14H,5-6,10H2,1-2H3,(H,23,27)/t14-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...


US Patent US10689345 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404585
PNG
((R)-3-(2-(4-chlorophenyl)pyrimidin-4-yl)-N-(1-cyan...)
Show SMILES Clc1ccc(cc1)-c1nccc(n1)C1CN(C1)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C19H19ClN6O/c20-15-3-1-13(2-4-15)18-22-7-5-17(24-18)14-9-26(10-14)19(27)23-16-6-8-25(11-16)12-21/h1-5,7,14,16H,6,8-11H2,(H,23,27)/t16-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...


US Patent US10689345 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404589
PNG
((3aR,6aR)-5-cyano-N-(3-(2-methylpyridin-4-yl)pheny...)
Show SMILES Cc1cc(ccn1)-c1cccc(NC(=O)N2CC[C@@H]3CN(C[C@H]23)C#N)c1
Show InChI InChI=1S/C20H21N5O/c1-14-9-16(5-7-22-14)15-3-2-4-18(10-15)23-20(26)25-8-6-17-11-24(13-21)12-19(17)25/h2-5,7,9-10,17,19H,6,8,11-12H2,1H3,(H,23,26)/t17-,19+/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...


US Patent US10689345 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404385
PNG
((R)-4-(3-chloropyridin-4-yl)-N- (1-cyanopyrrolidin...)
Show SMILES Clc1cnccc1-c1ccc(cc1)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C17H15ClN4O/c18-16-9-20-7-5-15(16)12-1-3-13(4-2-12)17(23)21-14-6-8-22(10-14)11-19/h1-5,7,9,14H,6,8,10H2,(H,21,23)/t14-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...


US Patent US10689345 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404438
PNG
((3aR,6aR)-5-cyano-N-(2-fluoro-4-(trifluoromethyl)p...)
Show SMILES Fc1cc(ccc1NC(=O)N1CC[C@@H]2CN(C[C@H]12)C#N)C(F)(F)F
Show InChI InChI=1S/C15H14F4N4O/c16-11-5-10(15(17,18)19)1-2-12(11)21-14(24)23-4-3-9-6-22(8-20)7-13(9)23/h1-2,5,9,13H,3-4,6-7H2,(H,21,24)/t9-,13+/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...


US Patent US10689345 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM447610
PNG
((R)-N-(1-cyanopyrrolidin- 3-yl)-2-fluoro-4-((4- me...)
Show SMILES CCc1ccnc(Nc2ccc(C(=O)N[C@@H]3CCN(C3)C#N)c(F)c2)n1
Show InChI InChI=1S/C18H19FN6O/c1-2-12-5-7-21-18(23-12)24-13-3-4-15(16(19)9-13)17(26)22-14-6-8-25(10-14)11-20/h3-5,7,9,14H,2,6,8,10H2,1H3,(H,22,26)(H,21,23,24)/t14-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...


US Patent US10689345 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404587
PNG
((R)-N-(1-cyanopyrrolidin-3-yl)-1-(4-cyclopropylpyr...)
Show SMILES O=C(N[C@@H]1CCN(C1)C#N)c1ccc2N(CCc2c1)c1nccc(n1)C1CC1
Show InChI InChI=1S/C21H22N6O/c22-13-26-9-7-17(12-26)24-20(28)16-3-4-19-15(11-16)6-10-27(19)21-23-8-5-18(25-21)14-1-2-14/h3-5,8,11,14,17H,1-2,6-7,9-10,12H2,(H,24,28)/t17-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...


US Patent US10689345 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM447731
PNG
((R)-N-(1- cyanopyrrolidin- 3-yl)-3-(3,4- dimethylp...)
Show SMILES Cc1ccc(cc1C)-c1cc(on1)C(=O)N[C@H]1CCN(C1)C#N
Show InChI InChI=1S/C17H18N4O2/c1-11-3-4-13(7-12(11)2)15-8-16(23-20-15)17(22)19-14-5-6-21(9-14)10-18/h3-4,7-8,14H,5-6,9H2,1-2H3,(H,19,22)/t14-/m0/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...


US Patent US10689345 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404355
PNG
(N-(1-cyanopyrrolidin-3-yl)-2'- methoxy-[1,1'-biphe...)
Show SMILES COc1ccccc1-c1ccc(cc1)C(=O)NC1CCN(C1)C#N
Show InChI InChI=1S/C19H19N3O2/c1-24-18-5-3-2-4-17(18)14-6-8-15(9-7-14)19(23)21-16-10-11-22(12-16)13-20/h2-9,16H,10-12H2,1H3,(H,21,23)
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...


US Patent US10689345 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404382
PNG
((R)-N-(1-cyanopyrrolidin-3-yl)- [1,1'-biphenyl]-4-...)
Show SMILES O=C(N[C@@H]1CCN(C1)C#N)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C18H17N3O/c19-13-21-11-10-17(12-21)20-18(22)16-8-6-15(7-9-16)14-4-2-1-3-5-14/h1-9,17H,10-12H2,(H,20,22)/t17-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...


US Patent US10689345 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404387
PNG
((R)-N-(1-cyanopyrrolidin-3-yl)-3- methoxy-4-(2-met...)
Show SMILES COc1cc(ccc1-c1ccnc(C)c1)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C19H20N4O2/c1-13-9-14(5-7-21-13)17-4-3-15(10-18(17)25-2)19(24)22-16-6-8-23(11-16)12-20/h3-5,7,9-10,16H,6,8,11H2,1-2H3,(H,22,24)/t16-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...


US Patent US10689345 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404441
PNG
(2-(2-chlorophenyl)-N-((trans)-1-cyano-4-hydroxypyr...)
Show SMILES O[C@H]1CN(C[C@@H]1NC(=O)c1cnc(s1)-c1ccccc1Cl)C#N
Show InChI InChI=1S/C15H13ClN4O2S/c16-10-4-2-1-3-9(10)15-18-5-13(23-15)14(22)19-11-6-20(8-17)7-12(11)21/h1-5,11-12,21H,6-7H2,(H,19,22)/t11-,12-/m0/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...


US Patent US10689345 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM447556
PNG
((R)-N-(1-cyanopyrrolidin- 3-yl)-5-(4-methoxyphenyl...)
Show SMILES COc1ccc(cc1)-c1cc(n[nH]1)C(=O)NC1CCN(C1)C#N
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...


US Patent US10689345 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM447558
PNG
((R)-N-(1-cyanopyrrolidin- 3-yl)-5-(2-methoxyphenyl...)
Show SMILES COc1ccccc1-c1cc(n[nH]1)C(=O)NC1CCN(C1)C#N
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...


US Patent US10689345 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM447581
PNG
((R)-N-(1-cyanopyrrolidin- 3-yl)-3-fluoro-5-(1-meth...)
Show SMILES Cn1ncc2cc(ccc12)-c1cnc(c(F)c1)-c1ccc2c(cnn2c1)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C26H21FN8O/c1-33-23-4-2-16(8-19(23)11-30-33)18-9-22(27)25(29-10-18)17-3-5-24-21(12-31-35(24)13-17)26(36)32-20-6-7-34(14-20)15-28/h2-5,8-13,20H,6-7,14H2,1H3,(H,32,36)/t20-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...


US Patent US10689345 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404508
PNG
((R)-7-(3-cyanophenyl)-N-(1-cyanopyrrolidin-3-yl)im...)
Show SMILES O=C(N[C@@H]1CCN(C1)C#N)c1cnc2cc(ccn12)-c1cccc(c1)C#N
Show InChI InChI=1S/C20H16N6O/c21-10-14-2-1-3-15(8-14)16-4-7-26-18(11-23-19(26)9-16)20(27)24-17-5-6-25(12-17)13-22/h1-4,7-9,11,17H,5-6,12H2,(H,24,27)/t17-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...


US Patent US10689345 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404569
PNG
((R)-N-(1-cyanopyrrolidin-3-yl)-3-(3-methoxyphenyl)...)
Show SMILES COc1cccc(c1)-c1cc(on1)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C16H16N4O3/c1-22-13-4-2-3-11(7-13)14-8-15(23-19-14)16(21)18-12-5-6-20(9-12)10-17/h2-4,7-8,12H,5-6,9H2,1H3,(H,18,21)/t12-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...


US Patent US10689345 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404571
PNG
((R)-N-(1-cyanopyrrolidin-3-yl)-3-fluoro-4-(4-methy...)
Show SMILES Cc1cn(cn1)-c1ccc(cc1F)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C16H16FN5O/c1-11-7-22(10-19-11)15-3-2-12(6-14(15)17)16(23)20-13-4-5-21(8-13)9-18/h2-3,6-7,10,13H,4-5,8H2,1H3,(H,20,23)/t13-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...


US Patent US10689345 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404383
PNG
((R)-6-(4-chlorophenyl)-N-(1- cyanopyrrolidin-3-yl)...)
Show SMILES Clc1ccc(cc1)-c1ccc(cn1)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C17H15ClN4O/c18-14-4-1-12(2-5-14)16-6-3-13(9-20-16)17(23)21-15-7-8-22(10-15)11-19/h1-6,9,15H,7-8,10H2,(H,21,23)/t15-/m1/s1
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Mission Therapeutics Limited

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Assay Description
USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...


US Patent US10689345 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404384
PNG
((R)-2-(2-chlorophenyl)-N-(1- cyanopyrrolidin-3-yl)...)
Show SMILES Clc1ccccc1-c1ncc(s1)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C15H13ClN4OS/c16-12-4-2-1-3-11(12)15-18-7-13(22-15)14(21)19-10-5-6-20(8-10)9-17/h1-4,7,10H,5-6,8H2,(H,19,21)/t10-/m1/s1
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Mission Therapeutics Limited

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Assay Description
USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...


US Patent US10689345 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404425
PNG
((R)-N-(1-cyanopyrrolidin-3-yl)-2- fluoro-4-(1-meth...)
Show SMILES Cn1cc(cn1)-c1ccc(C(=O)N[C@@H]2CCN(C2)C#N)c(F)c1
Show InChI InChI=1S/C16H16FN5O/c1-21-8-12(7-19-21)11-2-3-14(15(17)6-11)16(23)20-13-4-5-22(9-13)10-18/h2-3,6-8,13H,4-5,9H2,1H3,(H,20,23)/t13-/m1/s1
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Mission Therapeutics Limited

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Assay Description
USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...


US Patent US10689345 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404426
PNG
((R)-N-(1-cyanopyrrolidin-3-yl)- 2,5-difluoro-4-(1-...)
Show SMILES Cn1cc(cn1)-c1cc(F)c(cc1F)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C16H15F2N5O/c1-22-7-10(6-20-22)12-4-15(18)13(5-14(12)17)16(24)21-11-2-3-23(8-11)9-19/h4-7,11H,2-3,8H2,1H3,(H,21,24)/t11-/m1/s1
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Mission Therapeutics Limited

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Assay Description
USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...


US Patent US10689345 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404429
PNG
((R)-N-(1-cyanopyrrolidin-3-yl)-4- (1-ethyl-1H-pyra...)
Show SMILES CCn1cc(cn1)-c1ccc(C(=O)N[C@@H]2CCN(C2)C#N)c(F)c1
Show InChI InChI=1S/C17H18FN5O/c1-2-23-9-13(8-20-23)12-3-4-15(16(18)7-12)17(24)21-14-5-6-22(10-14)11-19/h3-4,7-9,14H,2,5-6,10H2,1H3,(H,21,24)/t14-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...


US Patent US10689345 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM447559
PNG
((R)-N-(1-cyanopyrrolidin- 3-yl)-5-(2-fluorophenyl)...)
Show SMILES Oc1ccccc1-c1cc(n[nH]1)C(=O)NC1CCN(C1)C#N
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...


US Patent US10689345 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM447584
PNG
((R)-3-chloro-N-(1- cyanopyrrolidin-3-yl)-5- (4-flu...)
Show SMILES Fc1ccc(cc1)-c1cnc(c(Cl)c1)-c1cnc(C(=O)N[C@@H]2CCN(C2)C#N)c(F)c1
Show InChI InChI=1S/C22H16ClF2N5O/c23-18-7-14(13-1-3-16(24)4-2-13)9-27-20(18)15-8-19(25)21(28-10-15)22(31)29-17-5-6-30(11-17)12-26/h1-4,7-10,17H,5-6,11H2,(H,29,31)/t17-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...


US Patent US10689345 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM447592
PNG
((R)-N-(1-cyanopyrrolidin- 3-yl)-2,3-difluoro-4-(1-...)
Show SMILES Cn1cc(cn1)-c1ccc(C(=O)N[C@@H]2CCN(C2)C#N)c(F)c1F
Show InChI InChI=1S/C16H15F2N5O/c1-22-7-10(6-20-22)12-2-3-13(15(18)14(12)17)16(24)21-11-4-5-23(8-11)9-19/h2-3,6-7,11H,4-5,8H2,1H3,(H,21,24)/t11-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...


US Patent US10689345 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404502
PNG
((R)-N-(1-cyanopyrrolidin-3-yl)-6-(3, 5-dimethyliso...)
Show SMILES CC(C)Cn1nc(C(=O)N[C@@H]2CCN(C2)C#N)c2ccc(cc12)-c1c(C)noc1C
Show InChI InChI=1S/C22H26N6O2/c1-13(2)10-28-19-9-16(20-14(3)26-30-15(20)4)5-6-18(19)21(25-28)22(29)24-17-7-8-27(11-17)12-23/h5-6,9,13,17H,7-8,10-11H2,1-4H3,(H,24,29)/t17-/m1/s1
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Mission Therapeutics Limited

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Assay Description
USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...


US Patent US10689345 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM447658
PNG
((3aR,6aR)-5-cyano-N-(2- fluoro-4-(trifluoromethoxy...)
Show SMILES Fc1cc(OC(F)(F)F)ccc1NC(=O)N1CC[C@@H]2CN(C[C@H]12)C#N
Show InChI InChI=1S/C15H14F4N4O2/c16-11-5-10(25-15(17,18)19)1-2-12(11)21-14(24)23-4-3-9-6-22(8-20)7-13(9)23/h1-2,5,9,13H,3-4,6-7H2,(H,21,24)/t9-,13+/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...


US Patent US10689345 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM447663
PNG
((3aR,6aR)-5-cyano-N-(5- phenylpyridin-2-yl) hexahy...)
Show SMILES Cc1ccc(NC(=O)N2CC[C@@H]3CN(C[C@H]23)C#N)nc1
Show InChI InChI=1S/C14H17N5O/c1-10-2-3-13(16-6-10)17-14(20)19-5-4-11-7-18(9-15)8-12(11)19/h2-3,6,11-12H,4-5,7-8H2,1H3,(H,16,17,20)/t11-,12+/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...


US Patent US10689345 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM447679
PNG
((R)-3-(4-chlorophenyl)-N-(1-cyanopyrrolidin-3-yl)i...)
Show SMILES CC(C)(C)OC(=O)N1CC[C@H](C1)NC(=O)c1cc(no1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C19H22ClN3O4/c1-19(2,3)26-18(25)23-9-8-14(11-23)21-17(24)16-10-15(22-27-16)12-4-6-13(20)7-5-12/h4-7,10,14H,8-9,11H2,1-3H3,(H,21,24)/t14-/m1/s1
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Mission Therapeutics Limited

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Assay Description
USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...


US Patent US10689345 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404602
PNG
(1-[1,1''-biphenyl]-4-yl)-3-(1- cyanopyrrolidin-3-y...)
Show SMILES O=C(NC1CCN(C1)C#N)Nc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C18H18N4O/c19-13-22-11-10-17(12-22)21-18(23)20-16-8-6-15(7-9-16)14-4-2-1-3-5-14/h1-9,17H,10-12H2,(H2,20,21,23)
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Mission Therapeutics Limited

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Assay Description
USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...


US Patent US10689345 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM447719
PNG
(3-([1,1'-biphenyl]-4-yl)-1-(1- cyanopyrrolidin-3-y...)
Show SMILES CN(C1CCN(C1)C#N)C(=O)Nc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C19H20N4O/c1-22(18-11-12-23(13-18)14-20)19(24)21-17-9-7-16(8-10-17)15-5-3-2-4-6-15/h2-10,18H,11-13H2,1H3,(H,21,24)
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Mission Therapeutics Limited

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Assay Description
USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...


US Patent US10689345 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404386
PNG
((R)-4-(3-chloropyridin-4-yl)-N- (1-cyanopyrrolidin...)
Show SMILES COc1cc(ccc1-c1ccncc1Cl)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C18H17ClN4O2/c1-25-17-8-12(18(24)22-13-5-7-23(10-13)11-20)2-3-15(17)14-4-6-21-9-16(14)19/h2-4,6,8-9,13H,5,7,10H2,1H3,(H,22,24)/t13-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...


US Patent US10689345 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404399
PNG
(US10343992, Example 51 | US10689345, Example 51 | ...)
Show SMILES O=C(N1CCC2CN(CC12)C#N)c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C20H19N3O/c21-14-22-12-18-9-10-23(19(18)13-22)20(24)17-8-4-7-16(11-17)15-5-2-1-3-6-15/h1-8,11,18-19H,9-10,12-13H2
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Mission Therapeutics Limited

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Assay Description
USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...


US Patent US10689345 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404460
PNG
((R)-N-(1-cyanopyrrolidin- 3-yl)-3,5-difluoro-4-(1-...)
Show SMILES Cn1cc(cn1)-c1c(F)cc(cc1F)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C16H15F2N5O/c1-22-7-11(6-20-22)15-13(17)4-10(5-14(15)18)16(24)21-12-2-3-23(8-12)9-19/h4-7,12H,2-3,8H2,1H3,(H,21,24)/t12-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...


US Patent US10689345 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404493
PNG
((R)-N-(1-cyanopyrrolidin- 3-yl)-2,5-difluoro-4- (p...)
Show SMILES Fc1cc(C(=O)N[C@@H]2CCN(C2)C#N)c(F)cc1N1CCCC1
Show InChI InChI=1S/C16H18F2N4O/c17-13-8-15(22-4-1-2-5-22)14(18)7-12(13)16(23)20-11-3-6-21(9-11)10-19/h7-8,11H,1-6,9H2,(H,20,23)/t11-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...


US Patent US10689345 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404529
PNG
((R)-N-(1-cyanopyrrolidin-3-yl)-4-(2, 6-dimethylpyr...)
Show SMILES Cc1cc(nc(C)n1)-c1ccc(C(=O)N[C@@H]2CCN(C2)C#N)c(F)c1
Show InChI InChI=1S/C18H18FN5O/c1-11-7-17(22-12(2)21-11)13-3-4-15(16(19)8-13)18(25)23-14-5-6-24(9-14)10-20/h3-4,7-8,14H,5-6,9H2,1-2H3,(H,23,25)/t14-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...


US Patent US10689345 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404530
PNG
((R)-N-(1- cyanopyrrolidin- 3-yl)-2-fluoro-4- (5-fl...)
Show SMILES Cc1ncc(F)c(n1)-c1ccc(C(=O)N[C@@H]2CCN(C2)C#N)c(F)c1
Show InChI InChI=1S/C17H15F2N5O/c1-10-21-7-15(19)16(22-10)11-2-3-13(14(18)6-11)17(25)23-12-4-5-24(8-12)9-20/h2-3,6-7,12H,4-5,8H2,1H3,(H,23,25)/t12-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...


US Patent US10689345 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM447664
PNG
((3aR,6aR)-5-cyano-N-(4- (trifluoromethyl)-phenyl)-...)
Show SMILES CC(F)(F)c1ccc(NC(=O)N2CC[C@@H]3CN(C[C@H]23)C#N)cc1
Show InChI InChI=1S/C16H18F2N4O/c1-16(17,18)12-2-4-13(5-3-12)20-15(23)22-7-6-11-8-21(10-19)9-14(11)22/h2-5,11,14H,6-9H2,1H3,(H,20,23)/t11-,14+/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...


US Patent US10689345 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404560
PNG
((R)-N-(1-cyanopyrrolidin-3-yl)-4-(4-cyclopropylpyr...)
Show SMILES O=C(N[C@@H]1CCN(C1)C#N)c1ccc2N(CCOc2c1)c1nccc(n1)C1CC1
Show InChI InChI=1S/C21H22N6O2/c22-13-26-8-6-16(12-26)24-20(28)15-3-4-18-19(11-15)29-10-9-27(18)21-23-7-5-17(25-21)14-1-2-14/h3-5,7,11,14,16H,1-2,6,8-10,12H2,(H,24,28)/t16-/m1/s1
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Mission Therapeutics Limited

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Assay Description
USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...


US Patent US10689345 (2020)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404561
PNG
((R)-N-(1-cyanopyrrolidin-3-yl)-4-((4-cyclopropylpy...)
Show SMILES Fc1cc(ccc1Nc1nccc(n1)C1CC1)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C19H19FN6O/c20-15-9-13(18(27)23-14-6-8-26(10-14)11-21)3-4-17(15)25-19-22-7-5-16(24-19)12-1-2-12/h3-5,7,9,12,14H,1-2,6,8,10H2,(H,23,27)(H,22,24,25)/t14-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...


US Patent US10689345 (2020)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%