BindingDB logo
myBDB logout

Patent code US10689362

Compile Data Set for Download or QSAR

Found 508 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM447582
PNG
(3-(4-acetylpiperazin-1-yl)-6-((3-methoxy-4-((4-met...)
Show SMILES COc1ccc(COc2ccc(Nc3ccc4ncc(nc4c3C#N)N3CCN(CC3)C(C)=O)cc2OC)cc1
Show InChI InChI=1S/C30H30N6O4/c1-20(37)35-12-14-36(15-13-35)29-18-32-26-10-9-25(24(17-31)30(26)34-29)33-22-6-11-27(28(16-22)39-3)40-19-21-4-7-23(38-2)8-5-21/h4-11,16,18,33H,12-15,19H2,1-3H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
27.5n/an/an/an/an/an/an/an/a



Development Center for Biotechnology

US Patent


Assay Description
c-KIT: Inhibition of c-KIT kinase activity by a test compound disclosed herein was estimated by radiometric assay. Standard assay conditions were 20 ...


US Patent US10689362 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM447603
PNG
(3-(4-(dimethylamino)piperidin-1-yl)-6-((4-((3-fluo...)
Show SMILES COc1cc(Nc2ccc3ncc(nc3c2C#N)N2CCC(CC2)N(C)C)ccc1OCc1cccc(F)c1
Show InChI InChI=1S/C30H31FN6O2/c1-36(2)23-11-13-37(14-12-23)29-18-33-26-9-8-25(24(17-32)30(26)35-29)34-22-7-10-27(28(16-22)38-3)39-19-20-5-4-6-21(31)15-20/h4-10,15-16,18,23,34H,11-14,19H2,1-3H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
27.5n/an/an/an/an/an/an/an/a



Development Center for Biotechnology

US Patent


Assay Description
c-KIT: Inhibition of c-KIT kinase activity by a test compound disclosed herein was estimated by radiometric assay. Standard assay conditions were 20 ...


US Patent US10689362 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM447666
PNG
(3-(dimethylamino)-6-((3-methoxy-4-((6-methoxypyrid...)
Show SMILES COc1ccc(COc2ccc(Nc3ccc4ncc(nc4c3C#N)N(C)C)cc2OC)cn1
Show InChI InChI=1S/C25H24N6O3/c1-31(2)23-14-27-20-8-7-19(18(12-26)25(20)30-23)29-17-6-9-21(22(11-17)32-3)34-15-16-5-10-24(33-4)28-13-16/h5-11,13-14,29H,15H2,1-4H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
27.5n/an/an/an/an/an/an/an/a



Development Center for Biotechnology

US Patent


Assay Description
c-KIT: Inhibition of c-KIT kinase activity by a test compound disclosed herein was estimated by radiometric assay. Standard assay conditions were 20 ...


US Patent US10689362 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM447544
PNG
(6-((3-methoxy-4-(pyrazin-2-ylmethoxy)phenyl)amino)...)
Show SMILES COc1cc(Nc2ccc3ncc(nc3c2C#N)N2CCOCC2)ccc1OCc1cnccn1
Show InChI InChI=1S/C25H23N7O3/c1-33-23-12-17(2-5-22(23)35-16-18-14-27-6-7-28-18)30-20-3-4-21-25(19(20)13-26)31-24(15-29-21)32-8-10-34-11-9-32/h2-7,12,14-15,30H,8-11,16H2,1H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
27.5n/an/an/an/an/an/an/an/a



Development Center for Biotechnology

US Patent


Assay Description
c-KIT: Inhibition of c-KIT kinase activity by a test compound disclosed herein was estimated by radiometric assay. Standard assay conditions were 20 ...


US Patent US10689362 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM447596
PNG
(6-((4-((3-cyanobenzyl)oxy)-3-methoxyphenyl)amino)-...)
Show SMILES COc1cc(Nc2ccc3ncc(nc3c2C#N)N2CCC(CC2)N(C)C)ccc1OCc1cccc(c1)C#N
Show InChI InChI=1S/C31H31N7O2/c1-37(2)24-11-13-38(14-12-24)30-19-34-27-9-8-26(25(18-33)31(27)36-30)35-23-7-10-28(29(16-23)39-3)40-20-22-6-4-5-21(15-22)17-32/h4-10,15-16,19,24,35H,11-14,20H2,1-3H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
27.5n/an/an/an/an/an/an/an/a



Development Center for Biotechnology

US Patent


Assay Description
c-KIT: Inhibition of c-KIT kinase activity by a test compound disclosed herein was estimated by radiometric assay. Standard assay conditions were 20 ...


US Patent US10689362 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM447611
PNG
(6-((4-((2-fluoro-4-methoxybenzyl)oxy)-3-methoxyphe...)
Show SMILES COc1ccc(COc2ccc(Nc3ccc4ncc(nc4c3C#N)N3CCOCC3)cc2OC)c(F)c1
Show InChI InChI=1S/C28H26FN5O4/c1-35-20-5-3-18(22(29)14-20)17-38-25-8-4-19(13-26(25)36-2)32-23-6-7-24-28(21(23)15-30)33-27(16-31-24)34-9-11-37-12-10-34/h3-8,13-14,16,32H,9-12,17H2,1-2H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
27.5n/an/an/an/an/an/an/an/a



Development Center for Biotechnology

US Patent


Assay Description
c-KIT: Inhibition of c-KIT kinase activity by a test compound disclosed herein was estimated by radiometric assay. Standard assay conditions were 20 ...


US Patent US10689362 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM447618
PNG
(6-((4-((6-ethylpyridin-3-yl)methoxy)-3-methoxyphen...)
Show SMILES CCc1ccc(COc2ccc(Nc3ccc4ncc(nc4c3C#N)N3CCOCC3)cc2OC)cn1
Show InChI InChI=1S/C28H28N6O3/c1-3-20-5-4-19(16-30-20)18-37-25-9-6-21(14-26(25)35-2)32-23-7-8-24-28(22(23)15-29)33-27(17-31-24)34-10-12-36-13-11-34/h4-9,14,16-17,32H,3,10-13,18H2,1-2H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
27.5n/an/an/an/an/an/an/an/a



Development Center for Biotechnology

US Patent


Assay Description
c-KIT: Inhibition of c-KIT kinase activity by a test compound disclosed herein was estimated by radiometric assay. Standard assay conditions were 20 ...


US Patent US10689362 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM447620
PNG
(6-((4-((6-isopropylpyridin-3-yl)methoxy)-3-methoxy...)
Show SMILES COc1cc(Nc2ccc3ncc(nc3c2C#N)N2CCOCC2)ccc1OCc1ccc(nc1)C(C)C
Show InChI InChI=1S/C29H30N6O3/c1-19(2)23-6-4-20(16-31-23)18-38-26-9-5-21(14-27(26)36-3)33-24-7-8-25-29(22(24)15-30)34-28(17-32-25)35-10-12-37-13-11-35/h4-9,14,16-17,19,33H,10-13,18H2,1-3H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
27.5n/an/an/an/an/an/an/an/a



Development Center for Biotechnology

US Patent


Assay Description
c-KIT: Inhibition of c-KIT kinase activity by a test compound disclosed herein was estimated by radiometric assay. Standard assay conditions were 20 ...


US Patent US10689362 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM447531
PNG
(6-((4-((4-ethylbenzyl)oxy)-3-methoxyphenyl)amino)-...)
Show SMILES CCc1ccc(COc2ccc(Nc3ccc4ncc(nc4c3C#N)N3CCOCC3)cc2OC)cc1
Show InChI InChI=1S/C29H29N5O3/c1-3-20-4-6-21(7-5-20)19-37-26-11-8-22(16-27(26)35-2)32-24-9-10-25-29(23(24)17-30)33-28(18-31-25)34-12-14-36-15-13-34/h4-11,16,18,32H,3,12-15,19H2,1-2H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
27.5n/an/an/an/an/an/an/an/a



Development Center for Biotechnology

US Patent


Assay Description
c-KIT: Inhibition of c-KIT kinase activity by a test compound disclosed herein was estimated by radiometric assay. Standard assay conditions were 20 ...


US Patent US10689362 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM447547
PNG
(6-((3-methoxy-4-((6-methylpyridin-3-yl)methoxy)phe...)
Show SMILES COc1cc(Nc2ccc3ncc(nc3c2C#N)N2CCOCC2)ccc1OCc1ccc(C)nc1
Show InChI InChI=1S/C27H26N6O3/c1-18-3-4-19(15-29-18)17-36-24-8-5-20(13-25(24)34-2)31-22-6-7-23-27(21(22)14-28)32-26(16-30-23)33-9-11-35-12-10-33/h3-8,13,15-16,31H,9-12,17H2,1-2H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
27.5n/an/an/an/an/an/an/an/a



Development Center for Biotechnology

US Patent


Assay Description
c-KIT: Inhibition of c-KIT kinase activity by a test compound disclosed herein was estimated by radiometric assay. Standard assay conditions were 20 ...


US Patent US10689362 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM447575
PNG
((1-(8-cyano-7-((3-methoxy-4-((4-methoxybenzyl)oxy)...)
Show SMILES COc1ccc(COc2ccc(Nc3ccc4ncc(nc4c3C#N)N3CCC(COC(C)=O)CC3)cc2OC)cc1
Show InChI InChI=1S/C32H33N5O5/c1-21(38)41-19-23-12-14-37(15-13-23)31-18-34-28-10-9-27(26(17-33)32(28)36-31)35-24-6-11-29(30(16-24)40-3)42-20-22-4-7-25(39-2)8-5-22/h4-11,16,18,23,35H,12-15,19-20H2,1-3H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
27.5n/an/an/an/an/an/an/an/a



Development Center for Biotechnology

US Patent


Assay Description
c-KIT: Inhibition of c-KIT kinase activity by a test compound disclosed herein was estimated by radiometric assay. Standard assay conditions were 20 ...


US Patent US10689362 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM447583
PNG
(6-((3-methoxy-4-((6-(trifluoromethyl)pyridin-3-yl)...)
Show SMILES COc1cc(Nc2ccc3ncc(nc3c2C#N)N2CCOCC2)ccc1OCc1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C27H23F3N6O3/c1-37-23-12-18(3-6-22(23)39-16-17-2-7-24(33-14-17)27(28,29)30)34-20-4-5-21-26(19(20)13-31)35-25(15-32-21)36-8-10-38-11-9-36/h2-7,12,14-15,34H,8-11,16H2,1H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
27.5n/an/an/an/an/an/an/an/a



Development Center for Biotechnology

US Patent


Assay Description
c-KIT: Inhibition of c-KIT kinase activity by a test compound disclosed herein was estimated by radiometric assay. Standard assay conditions were 20 ...


US Patent US10689362 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM447600
PNG
(6-((4-(benzyloxy)-3-methoxyphenyl)amino)-3-morphol...)
Show SMILES COc1cc(Nc2ccc3ncc(nc3c2C#N)N2CCOCC2)ccc1OCc1ccccc1
Show InChI InChI=1S/C27H25N5O3/c1-33-25-15-20(7-10-24(25)35-18-19-5-3-2-4-6-19)30-22-8-9-23-27(21(22)16-28)31-26(17-29-23)32-11-13-34-14-12-32/h2-10,15,17,30H,11-14,18H2,1H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
27.5n/an/an/an/an/an/an/an/a



Development Center for Biotechnology

US Patent


Assay Description
c-KIT: Inhibition of c-KIT kinase activity by a test compound disclosed herein was estimated by radiometric assay. Standard assay conditions were 20 ...


US Patent US10689362 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM447604
PNG
(6-((3-methoxy-4-((4-methoxybenzyl)oxy)phenyl)amino...)
Show SMILES COc1ccc(COc2ccc(Nc3ccc4ncc(nc4c3C#N)N3CCNCC3)cc2OC)cc1
Show InChI InChI=1S/C28H28N6O3/c1-35-21-6-3-19(4-7-21)18-37-25-10-5-20(15-26(25)36-2)32-23-8-9-24-28(22(23)16-29)33-27(17-31-24)34-13-11-30-12-14-34/h3-10,15,17,30,32H,11-14,18H2,1-2H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
27.5n/an/an/an/an/an/an/an/a



Development Center for Biotechnology

US Patent


Assay Description
c-KIT: Inhibition of c-KIT kinase activity by a test compound disclosed herein was estimated by radiometric assay. Standard assay conditions were 20 ...


US Patent US10689362 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM447629
PNG
(6-((4-((6-ethoxypyridin-3-yl)methoxy)-3-methoxyphe...)
Show SMILES CCOc1ccc(COc2ccc(Nc3ccc4ncc(nc4c3C#N)N3CCOCC3)cc2OC)cn1
Show InChI InChI=1S/C28H28N6O4/c1-3-37-27-9-4-19(16-31-27)18-38-24-8-5-20(14-25(24)35-2)32-22-6-7-23-28(21(22)15-29)33-26(17-30-23)34-10-12-36-13-11-34/h4-9,14,16-17,32H,3,10-13,18H2,1-2H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
27.5n/an/an/an/an/an/an/an/a



Development Center for Biotechnology

US Patent


Assay Description
c-KIT: Inhibition of c-KIT kinase activity by a test compound disclosed herein was estimated by radiometric assay. Standard assay conditions were 20 ...


US Patent US10689362 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM447645
PNG
(6-((3-methoxy-4-((5-methylthiophen-2-yl)methoxy)ph...)
Show SMILES COc1cc(Nc2ccc3ncc(nc3c2C#N)N2CCOCC2)ccc1OCc1ccc(C)s1
Show InChI InChI=1S/C26H25N5O3S/c1-17-3-5-19(35-17)16-34-23-8-4-18(13-24(23)32-2)29-21-6-7-22-26(20(21)14-27)30-25(15-28-22)31-9-11-33-12-10-31/h3-8,13,15,29H,9-12,16H2,1-2H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
27.5n/an/an/an/an/an/an/an/a



Development Center for Biotechnology

US Patent


Assay Description
c-KIT: Inhibition of c-KIT kinase activity by a test compound disclosed herein was estimated by radiometric assay. Standard assay conditions were 20 ...


US Patent US10689362 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM447654
PNG
(3-(dimethylamino)-6-((3-methoxy-4-((6-methylpyridi...)
Show SMILES COc1cc(Nc2ccc3ncc(nc3c2C#N)N(C)C)ccc1OCc1ccc(C)nc1
Show InChI InChI=1S/C25H24N6O2/c1-16-5-6-17(13-27-16)15-33-22-10-7-18(11-23(22)32-4)29-20-8-9-21-25(19(20)12-26)30-24(14-28-21)31(2)3/h5-11,13-14,29H,15H2,1-4H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
27.5n/an/an/an/an/an/an/an/a



Development Center for Biotechnology

US Patent


Assay Description
c-KIT: Inhibition of c-KIT kinase activity by a test compound disclosed herein was estimated by radiometric assay. Standard assay conditions were 20 ...


US Patent US10689362 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM447673
PNG
(6-((4-((1-(cyclopropylmethyl)-1H-pyrazol-4-yl)meth...)
Show SMILES COc1cc(Nc2ccc3ncc(nc3c2C#N)N2CCOCC2)ccc1OCc1cnn(CC2CC2)c1
Show InChI InChI=1S/C28H29N7O3/c1-36-26-12-21(4-7-25(26)38-18-20-14-31-35(17-20)16-19-2-3-19)32-23-5-6-24-28(22(23)13-29)33-27(15-30-24)34-8-10-37-11-9-34/h4-7,12,14-15,17,19,32H,2-3,8-11,16,18H2,1H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
27.5n/an/an/an/an/an/an/an/a



Development Center for Biotechnology

US Patent


Assay Description
c-KIT: Inhibition of c-KIT kinase activity by a test compound disclosed herein was estimated by radiometric assay. Standard assay conditions were 20 ...


US Patent US10689362 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM447511
PNG
(3-(dimethylamino)-6-((3-methoxy-4-((4-methoxybenzy...)
Show SMILES COc1ccc(COc2ccc(Nc3ccc4ncc(nc4c3C#N)N(C)C)cc2OC)cc1
Show InChI InChI=1S/C26H25N5O3/c1-31(2)25-15-28-22-11-10-21(20(14-27)26(22)30-25)29-18-7-12-23(24(13-18)33-4)34-16-17-5-8-19(32-3)9-6-17/h5-13,15,29H,16H2,1-4H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
27.5n/an/an/an/an/an/an/an/a



Development Center for Biotechnology

US Patent


Assay Description
c-KIT: Inhibition of c-KIT kinase activity by a test compound disclosed herein was estimated by radiometric assay. Standard assay conditions were 20 ...


US Patent US10689362 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM447539
PNG
(6-((4-((2,3-dihydrobenzofuran-5-yl)methoxy)-3-meth...)
Show SMILES COc1cc(Nc2ccc3ncc(nc3c2C#N)N2CCOCC2)ccc1OCc1ccc2OCCc2c1
Show InChI InChI=1S/C29H27N5O4/c1-35-27-15-21(3-7-26(27)38-18-19-2-6-25-20(14-19)8-11-37-25)32-23-4-5-24-29(22(23)16-30)33-28(17-31-24)34-9-12-36-13-10-34/h2-7,14-15,17,32H,8-13,18H2,1H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
27.5n/an/an/an/an/an/an/an/a



Development Center for Biotechnology

US Patent


Assay Description
c-KIT: Inhibition of c-KIT kinase activity by a test compound disclosed herein was estimated by radiometric assay. Standard assay conditions were 20 ...


US Patent US10689362 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM447542
PNG
(6-((4-((4-chlorobenzyl)oxy)-3-methoxyphenyl)amino)...)
Show SMILES COc1cc(Nc2ccc3ncc(nc3c2C#N)N2CCOCC2)ccc1OCc1ccc(Cl)cc1
Show InChI InChI=1S/C27H24ClN5O3/c1-34-25-14-20(6-9-24(25)36-17-18-2-4-19(28)5-3-18)31-22-7-8-23-27(21(22)15-29)32-26(16-30-23)33-10-12-35-13-11-33/h2-9,14,16,31H,10-13,17H2,1H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
27.5n/an/an/an/an/an/an/an/a



Development Center for Biotechnology

US Patent


Assay Description
c-KIT: Inhibition of c-KIT kinase activity by a test compound disclosed herein was estimated by radiometric assay. Standard assay conditions were 20 ...


US Patent US10689362 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM447567
PNG
(6-((4-((4-cyanobenzyl)oxy)-3-methoxyphenyl)amino)-...)
Show SMILES COc1cc(Nc2ccc3ncc(nc3c2C#N)N2CCOCC2)ccc1OCc1ccc(cc1)C#N
Show InChI InChI=1S/C28H24N6O3/c1-35-26-14-21(6-9-25(26)37-18-20-4-2-19(15-29)3-5-20)32-23-7-8-24-28(22(23)16-30)33-27(17-31-24)34-10-12-36-13-11-34/h2-9,14,17,32H,10-13,18H2,1H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
27.5n/an/an/an/an/an/an/an/a



Development Center for Biotechnology

US Patent


Assay Description
c-KIT: Inhibition of c-KIT kinase activity by a test compound disclosed herein was estimated by radiometric assay. Standard assay conditions were 20 ...


US Patent US10689362 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM447585
PNG
(2-(4-(8-cyano-7-((3-methoxy-4-((6-methoxypyridin-3...)
Show SMILES COc1ccc(COc2ccc(Nc3ccc4ncc(nc4c3C#N)N3CCN(CCOC(C)=O)CC3)cc2OC)cn1
Show InChI InChI=1S/C31H33N7O5/c1-21(39)42-15-14-37-10-12-38(13-11-37)29-19-33-26-7-6-25(24(17-32)31(26)36-29)35-23-5-8-27(28(16-23)40-2)43-20-22-4-9-30(41-3)34-18-22/h4-9,16,18-19,35H,10-15,20H2,1-3H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
27.5n/an/an/an/an/an/an/an/a



Development Center for Biotechnology

US Patent


Assay Description
c-KIT: Inhibition of c-KIT kinase activity by a test compound disclosed herein was estimated by radiometric assay. Standard assay conditions were 20 ...


US Patent US10689362 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM447630
PNG
(3-(3,6-dihydro-2H-pyran-4-yl)-6-((3-methoxy-4-((6-...)
Show SMILES COc1cc(Nc2ccc3ncc(nc3c2C#N)C2=CCOCC2)ccc1OCc1ccc(C)nc1
Show InChI InChI=1S/C28H25N5O3/c1-18-3-4-19(15-30-18)17-36-26-8-5-21(13-27(26)34-2)32-23-6-7-24-28(22(23)14-29)33-25(16-31-24)20-9-11-35-12-10-20/h3-9,13,15-16,32H,10-12,17H2,1-2H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
27.5n/an/an/an/an/an/an/an/a



Development Center for Biotechnology

US Patent


Assay Description
c-KIT: Inhibition of c-KIT kinase activity by a test compound disclosed herein was estimated by radiometric assay. Standard assay conditions were 20 ...


US Patent US10689362 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM447651
PNG
(6-((4-((6-cyclopropylpyridin-3-yl)methoxy)-3-metho...)
Show SMILES COc1cc(ccc1OCc1ccc(nc1)C1CC1)N(C)c1ccc2ncc(nc2c1C#N)N1CCOCC1
Show InChI InChI=1S/C30H30N6O3/c1-35(26-9-8-25-30(23(26)16-31)34-29(18-33-25)36-11-13-38-14-12-36)22-6-10-27(28(15-22)37-2)39-19-20-3-7-24(32-17-20)21-4-5-21/h3,6-10,15,17-18,21H,4-5,11-14,19H2,1-2H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
27.5n/an/an/an/an/an/an/an/a



Development Center for Biotechnology

US Patent


Assay Description
c-KIT: Inhibition of c-KIT kinase activity by a test compound disclosed herein was estimated by radiometric assay. Standard assay conditions were 20 ...


US Patent US10689362 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM447665
PNG
(3-(3-(dimethylamino)azetidin-1-yl)-6-((3-methoxy-4...)
Show SMILES COc1cc(Nc2ccc3ncc(nc3c2C#N)N2CC(C2)N(C)C)ccc1OCc1ccc(C)nc1
Show InChI InChI=1S/C28H29N7O2/c1-18-5-6-19(13-30-18)17-37-25-10-7-20(11-26(25)36-4)32-23-8-9-24-28(22(23)12-29)33-27(14-31-24)35-15-21(16-35)34(2)3/h5-11,13-14,21,32H,15-17H2,1-4H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
27.5n/an/an/an/an/an/an/an/a



Development Center for Biotechnology

US Patent


Assay Description
c-KIT: Inhibition of c-KIT kinase activity by a test compound disclosed herein was estimated by radiometric assay. Standard assay conditions were 20 ...


US Patent US10689362 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM447529
PNG
(6-((3-methoxy-4-((4-methoxybenzyl)oxy)phenyl)amino...)
Show SMILES COc1ccc(COc2ccc(Nc3ccc4ncc(nc4c3C#N)N3CCN(C)CC3)cc2OC)cc1
Show InChI InChI=1S/C29H30N6O3/c1-34-12-14-35(15-13-34)28-18-31-25-10-9-24(23(17-30)29(25)33-28)32-21-6-11-26(27(16-21)37-3)38-19-20-4-7-22(36-2)8-5-20/h4-11,16,18,32H,12-15,19H2,1-3H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
27.5n/an/an/an/an/an/an/an/a



Development Center for Biotechnology

US Patent


Assay Description
c-KIT: Inhibition of c-KIT kinase activity by a test compound disclosed herein was estimated by radiometric assay. Standard assay conditions were 20 ...


US Patent US10689362 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM447530
PNG
(6-((3-methoxy-4-((4-(trifluoromethoxy)benzyl)oxy)p...)
Show SMILES COc1cc(Nc2ccc3ncc(nc3c2C#N)N2CCOCC2)ccc1OCc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C28H24F3N5O4/c1-37-25-14-19(4-9-24(25)39-17-18-2-5-20(6-3-18)40-28(29,30)31)34-22-7-8-23-27(21(22)15-32)35-26(16-33-23)36-10-12-38-13-11-36/h2-9,14,16,34H,10-13,17H2,1H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
27.5n/an/an/an/an/an/an/an/a



Development Center for Biotechnology

US Patent


Assay Description
c-KIT: Inhibition of c-KIT kinase activity by a test compound disclosed herein was estimated by radiometric assay. Standard assay conditions were 20 ...


US Patent US10689362 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM447555
PNG
(6-((3-methoxy-4-((4-methoxybenzyl)oxy)phenyl)amino...)
Show SMILES COc1ccc(COc2ccc(Nc3ccc4ncc(nc4c3C#N)N3CCCC3)cc2OC)cc1
Show InChI InChI=1S/C28H27N5O3/c1-34-21-8-5-19(6-9-21)18-36-25-12-7-20(15-26(25)35-2)31-23-10-11-24-28(22(23)16-29)32-27(17-30-24)33-13-3-4-14-33/h5-12,15,17,31H,3-4,13-14,18H2,1-2H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
27.5n/an/an/an/an/an/an/an/a



Development Center for Biotechnology

US Patent


Assay Description
c-KIT: Inhibition of c-KIT kinase activity by a test compound disclosed herein was estimated by radiometric assay. Standard assay conditions were 20 ...


US Patent US10689362 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM447590
PNG
(6-((3-methoxy-4-((6-methoxypyridin-3-yl)methoxy)ph...)
Show SMILES COc1ccc(COc2ccc(Nc3ccc4ncc(nc4c3C#N)N3CCCC3)cc2OC)cn1
Show InChI InChI=1S/C27H26N6O3/c1-34-24-13-19(6-9-23(24)36-17-18-5-10-26(35-2)30-15-18)31-21-7-8-22-27(20(21)14-28)32-25(16-29-22)33-11-3-4-12-33/h5-10,13,15-16,31H,3-4,11-12,17H2,1-2H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
27.5n/an/an/an/an/an/an/an/a



Development Center for Biotechnology

US Patent


Assay Description
c-KIT: Inhibition of c-KIT kinase activity by a test compound disclosed herein was estimated by radiometric assay. Standard assay conditions were 20 ...


US Patent US10689362 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM447591
PNG
(3-(4-isopropylpiperazin-1-yl)-6-((3-methoxy-4-((4-...)
Show SMILES COc1ccc(COc2ccc(Nc3ccc4ncc(nc4c3C#N)N3CCN(CC3)C(C)C)cc2OC)cc1
Show InChI InChI=1S/C31H34N6O3/c1-21(2)36-13-15-37(16-14-36)30-19-33-27-11-10-26(25(18-32)31(27)35-30)34-23-7-12-28(29(17-23)39-4)40-20-22-5-8-24(38-3)9-6-22/h5-12,17,19,21,34H,13-16,20H2,1-4H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
27.5n/an/an/an/an/an/an/an/a



Development Center for Biotechnology

US Patent


Assay Description
c-KIT: Inhibition of c-KIT kinase activity by a test compound disclosed herein was estimated by radiometric assay. Standard assay conditions were 20 ...


US Patent US10689362 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM447615
PNG
(6-((3-methoxy-4-((6-propylpyridin-3-yl)methoxy)phe...)
Show SMILES CCCc1ccc(COc2ccc(Nc3ccc4ncc(nc4c3C#N)N3CCOCC3)cc2OC)cn1
Show InChI InChI=1S/C29H30N6O3/c1-3-4-21-6-5-20(17-31-21)19-38-26-10-7-22(15-27(26)36-2)33-24-8-9-25-29(23(24)16-30)34-28(18-32-25)35-11-13-37-14-12-35/h5-10,15,17-18,33H,3-4,11-14,19H2,1-2H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
27.5n/an/an/an/an/an/an/an/a



Development Center for Biotechnology

US Patent


Assay Description
c-KIT: Inhibition of c-KIT kinase activity by a test compound disclosed herein was estimated by radiometric assay. Standard assay conditions were 20 ...


US Patent US10689362 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM447641
PNG
(6-((4-((6-cyclopropylpyridin-3-yl)methoxy)-3-metho...)
Show SMILES COc1cc(Nc2ccc3ncc(nc3c2C#N)N2CCOCC2)ccc1OCc1ccc(nc1)C1CC1
Show InChI InChI=1S/C29H28N6O3/c1-36-27-14-21(5-9-26(27)38-18-19-2-6-23(31-16-19)20-3-4-20)33-24-7-8-25-29(22(24)15-30)34-28(17-32-25)35-10-12-37-13-11-35/h2,5-9,14,16-17,20,33H,3-4,10-13,18H2,1H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
27.5n/an/an/an/an/an/an/an/a



Development Center for Biotechnology

US Patent


Assay Description
c-KIT: Inhibition of c-KIT kinase activity by a test compound disclosed herein was estimated by radiometric assay. Standard assay conditions were 20 ...


US Patent US10689362 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM447516
PNG
(3-(isopropylamino)-6-((3-methoxy-4-((4-methoxybenz...)
Show SMILES COc1ccc(COc2ccc(Nc3ccc4ncc(NC(C)C)nc4c3C#N)cc2OC)cc1
Show InChI InChI=1S/C27H27N5O3/c1-17(2)30-26-15-29-23-11-10-22(21(14-28)27(23)32-26)31-19-7-12-24(25(13-19)34-4)35-16-18-5-8-20(33-3)9-6-18/h5-13,15,17,31H,16H2,1-4H3,(H,30,32)
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
27.5n/an/an/an/an/an/an/an/a



Development Center for Biotechnology

US Patent


Assay Description
c-KIT: Inhibition of c-KIT kinase activity by a test compound disclosed herein was estimated by radiometric assay. Standard assay conditions were 20 ...


US Patent US10689362 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM447515
PNG
(6-((3-methoxy-4-((4-methoxybenzyl)oxy)phenyl)amino...)
Show SMILES COc1ccc(COc2ccc(Nc3ccc4ncc(nc4c3C#N)N3CCOCC3)cc2OC)cc1
Show InChI InChI=1S/C28H27N5O4/c1-34-21-6-3-19(4-7-21)18-37-25-10-5-20(15-26(25)35-2)31-23-8-9-24-28(22(23)16-29)32-27(17-30-24)33-11-13-36-14-12-33/h3-10,15,17,31H,11-14,18H2,1-2H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
27.5n/an/an/an/an/an/an/an/a



Development Center for Biotechnology

US Patent


Assay Description
c-KIT: Inhibition of c-KIT kinase activity by a test compound disclosed herein was estimated by radiometric assay. Standard assay conditions were 20 ...


US Patent US10689362 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM447520
PNG
(N7-(3-methoxy-4-((4-methoxybenzyl)oxy)phenyl)-N2-m...)
Show SMILES CNc1cnc2ccc(Nc3ccc(OCc4ccc(OC)cc4)c(OC)c3)cc2n1
Show InChI InChI=1S/C24H24N4O3/c1-25-24-14-26-20-10-6-17(12-21(20)28-24)27-18-7-11-22(23(13-18)30-3)31-15-16-4-8-19(29-2)9-5-16/h4-14,27H,15H2,1-3H3,(H,25,28)
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
27.5n/an/an/an/an/an/an/an/a



Development Center for Biotechnology

US Patent


Assay Description
c-KIT: Inhibition of c-KIT kinase activity by a test compound disclosed herein was estimated by radiometric assay. Standard assay conditions were 20 ...


US Patent US10689362 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM447532
PNG
(6-((4-((4-ethoxybenzyl)oxy)-3-methoxyphenyl)amino)...)
Show SMILES CCOc1ccc(COc2ccc(Nc3ccc4ncc(nc4c3C#N)N3CCOCC3)cc2OC)cc1
Show InChI InChI=1S/C29H29N5O4/c1-3-37-22-7-4-20(5-8-22)19-38-26-11-6-21(16-27(26)35-2)32-24-9-10-25-29(23(24)17-30)33-28(18-31-25)34-12-14-36-15-13-34/h4-11,16,18,32H,3,12-15,19H2,1-2H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
27.5n/an/an/an/an/an/an/an/a



Development Center for Biotechnology

US Patent


Assay Description
c-KIT: Inhibition of c-KIT kinase activity by a test compound disclosed herein was estimated by radiometric assay. Standard assay conditions were 20 ...


US Patent US10689362 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM447535
PNG
(6-((4-((4-methoxybenzyl)oxy)phenyl)amino)-3-morpho...)
Show SMILES COc1ccc(COc2ccc(Nc3ccc4ncc(nc4c3C#N)N3CCOCC3)cc2)cc1
Show InChI InChI=1S/C27H25N5O3/c1-33-21-6-2-19(3-7-21)18-35-22-8-4-20(5-9-22)30-24-10-11-25-27(23(24)16-28)31-26(17-29-25)32-12-14-34-15-13-32/h2-11,17,30H,12-15,18H2,1H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
27.5n/an/an/an/an/an/an/an/a



Development Center for Biotechnology

US Patent


Assay Description
c-KIT: Inhibition of c-KIT kinase activity by a test compound disclosed herein was estimated by radiometric assay. Standard assay conditions were 20 ...


US Patent US10689362 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM447538
PNG
(6-((3-methoxy-4-(pyridin-3-ylmethoxy)phenyl)amino)...)
Show SMILES COc1cc(Nc2ccc3ncc(nc3c2C#N)N2CCOCC2)ccc1OCc1cccnc1
Show InChI InChI=1S/C26H24N6O3/c1-33-24-13-19(4-7-23(24)35-17-18-3-2-8-28-15-18)30-21-5-6-22-26(20(21)14-27)31-25(16-29-22)32-9-11-34-12-10-32/h2-8,13,15-16,30H,9-12,17H2,1H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
27.5n/an/an/an/an/an/an/an/a



Development Center for Biotechnology

US Patent


Assay Description
c-KIT: Inhibition of c-KIT kinase activity by a test compound disclosed herein was estimated by radiometric assay. Standard assay conditions were 20 ...


US Patent US10689362 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM447595
PNG
(3-(azetidin-1-yl)-6-((3-methoxy-4-((4-methoxybenzy...)
Show SMILES COc1ccc(COc2ccc(Nc3ccc4ncc(nc4c3C#N)N3CCC3)cc2OC)cc1
Show InChI InChI=1S/C27H25N5O3/c1-33-20-7-4-18(5-8-20)17-35-24-11-6-19(14-25(24)34-2)30-22-9-10-23-27(21(22)15-28)31-26(16-29-23)32-12-3-13-32/h4-11,14,16,30H,3,12-13,17H2,1-2H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
27.5n/an/an/an/an/an/an/an/a



Development Center for Biotechnology

US Patent


Assay Description
c-KIT: Inhibition of c-KIT kinase activity by a test compound disclosed herein was estimated by radiometric assay. Standard assay conditions were 20 ...


US Patent US10689362 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM447609
PNG
(6-((4-((3-fluoro-4-methoxybenzyl)oxy)-3-methoxy-ph...)
Show SMILES COc1ccc(COc2ccc(Nc3ccc4ncc(nc4c3C#N)N3CCOCC3)cc2OC)cc1F
Show InChI InChI=1S/C28H26FN5O4/c1-35-24-7-3-18(13-21(24)29)17-38-25-8-4-19(14-26(25)36-2)32-22-5-6-23-28(20(22)15-30)33-27(16-31-23)34-9-11-37-12-10-34/h3-8,13-14,16,32H,9-12,17H2,1-2H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
27.5n/an/an/an/an/an/an/an/a



Development Center for Biotechnology

US Patent


Assay Description
c-KIT: Inhibition of c-KIT kinase activity by a test compound disclosed herein was estimated by radiometric assay. Standard assay conditions were 20 ...


US Patent US10689362 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM447621
PNG
(6-((4-((6-(dimethylamino)pyridin-3-yl)methoxy)-3-m...)
Show SMILES COc1cc(Nc2ccc3ncc(nc3c2C#N)N2CCOCC2)ccc1OCc1ccc(nc1)N(C)C
Show InChI InChI=1S/C28H29N7O3/c1-34(2)26-9-4-19(16-31-26)18-38-24-8-5-20(14-25(24)36-3)32-22-6-7-23-28(21(22)15-29)33-27(17-30-23)35-10-12-37-13-11-35/h4-9,14,16-17,32H,10-13,18H2,1-3H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
27.5n/an/an/an/an/an/an/an/a



Development Center for Biotechnology

US Patent


Assay Description
c-KIT: Inhibition of c-KIT kinase activity by a test compound disclosed herein was estimated by radiometric assay. Standard assay conditions were 20 ...


US Patent US10689362 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM447643
PNG
(6-((4-(furan-2-ylmethoxy)-3-methoxyphenyl)amino)-3...)
Show SMILES COc1cc(Nc2ccc3ncc(nc3c2C#N)N2CCOCC2)ccc1OCc1ccco1
Show InChI InChI=1S/C25H23N5O4/c1-31-23-13-17(4-7-22(23)34-16-18-3-2-10-33-18)28-20-5-6-21-25(19(20)14-26)29-24(15-27-21)30-8-11-32-12-9-30/h2-7,10,13,15,28H,8-9,11-12,16H2,1H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
27.5n/an/an/an/an/an/an/an/a



Development Center for Biotechnology

US Patent


Assay Description
c-KIT: Inhibition of c-KIT kinase activity by a test compound disclosed herein was estimated by radiometric assay. Standard assay conditions were 20 ...


US Patent US10689362 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM447646
PNG
(6-((3-methoxy-4-((5-(methoxymethyl)pyridin-2-yl)me...)
Show SMILES COCc1ccc(COc2ccc(Nc3ccc4ncc(nc4c3C#N)N3CCOCC3)cc2OC)nc1
Show InChI InChI=1S/C28H28N6O4/c1-35-17-19-3-4-21(30-15-19)18-38-25-8-5-20(13-26(25)36-2)32-23-6-7-24-28(22(23)14-29)33-27(16-31-24)34-9-11-37-12-10-34/h3-8,13,15-16,32H,9-12,17-18H2,1-2H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
27.5n/an/an/an/an/an/an/an/a



Development Center for Biotechnology

US Patent


Assay Description
c-KIT: Inhibition of c-KIT kinase activity by a test compound disclosed herein was estimated by radiometric assay. Standard assay conditions were 20 ...


US Patent US10689362 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM447513
PNG
(6-((3-methoxy-4-((4-methoxybenzyl)oxy)phenyl)amino...)
Show SMILES CNc1cnc2ccc(Nc3ccc(OCc4ccc(OC)cc4)c(OC)c3)c(C#N)c2n1
Show InChI InChI=1S/C25H23N5O3/c1-27-24-14-28-21-10-9-20(19(13-26)25(21)30-24)29-17-6-11-22(23(12-17)32-3)33-15-16-4-7-18(31-2)8-5-16/h4-12,14,29H,15H2,1-3H3,(H,27,30)
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
27.5n/an/an/an/an/an/an/an/a



Development Center for Biotechnology

US Patent


Assay Description
c-KIT: Inhibition of c-KIT kinase activity by a test compound disclosed herein was estimated by radiometric assay. Standard assay conditions were 20 ...


US Patent US10689362 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM447572
PNG
(1-(8-cyano-7-((3-methoxy-4-((4-methoxybenzyl)oxy)p...)
Show SMILES COc1ccc(COc2ccc(Nc3ccc4ncc(nc4c3C#N)N3CCC(CC3)OC(C)=O)cc2OC)cc1
Show InChI InChI=1S/C31H31N5O5/c1-20(37)41-24-12-14-36(15-13-24)30-18-33-27-10-9-26(25(17-32)31(27)35-30)34-22-6-11-28(29(16-22)39-3)40-19-21-4-7-23(38-2)8-5-21/h4-11,16,18,24,34H,12-15,19H2,1-3H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
27.5n/an/an/an/an/an/an/an/a



Development Center for Biotechnology

US Patent


Assay Description
c-KIT: Inhibition of c-KIT kinase activity by a test compound disclosed herein was estimated by radiometric assay. Standard assay conditions were 20 ...


US Patent US10689362 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM447597
PNG
(3-(4-(dimethylamino)piperidin-1-yl)-6-((4-((3-fluo...)
Show SMILES COc1ccc(COc2ccc(Nc3ccc4ncc(nc4c3C#N)N3CCC(CC3)N(C)C)cc2OC)cc1F
Show InChI InChI=1S/C31H33FN6O3/c1-37(2)22-11-13-38(14-12-22)30-18-34-26-8-7-25(23(17-33)31(26)36-30)35-21-6-10-28(29(16-21)40-4)41-19-20-5-9-27(39-3)24(32)15-20/h5-10,15-16,18,22,35H,11-14,19H2,1-4H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
27.5n/an/an/an/an/an/an/an/a



Development Center for Biotechnology

US Patent


Assay Description
c-KIT: Inhibition of c-KIT kinase activity by a test compound disclosed herein was estimated by radiometric assay. Standard assay conditions were 20 ...


US Patent US10689362 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM447647
PNG
(6-((3-methoxy-4-(thiophen-3-ylmethoxy)phenyl)amino...)
Show SMILES COc1cc(Nc2ccc3ncc(nc3c2C#N)N2CCOCC2)ccc1OCc1ccsc1
Show InChI InChI=1S/C25H23N5O3S/c1-31-23-12-18(2-5-22(23)33-15-17-6-11-34-16-17)28-20-3-4-21-25(19(20)13-26)29-24(14-27-21)30-7-9-32-10-8-30/h2-6,11-12,14,16,28H,7-10,15H2,1H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
27.5n/an/an/an/an/an/an/an/a



Development Center for Biotechnology

US Patent


Assay Description
c-KIT: Inhibition of c-KIT kinase activity by a test compound disclosed herein was estimated by radiometric assay. Standard assay conditions were 20 ...


US Patent US10689362 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM447648
PNG
(6-((3-methoxy-4-(thiophen-2-ylmethoxy)phenyl)amino...)
Show SMILES COc1cc(Nc2ccc3ncc(nc3c2C#N)N2CCOCC2)ccc1OCc1cccs1
Show InChI InChI=1S/C25H23N5O3S/c1-31-23-13-17(4-7-22(23)33-16-18-3-2-12-34-18)28-20-5-6-21-25(19(20)14-26)29-24(15-27-21)30-8-10-32-11-9-30/h2-7,12-13,15,28H,8-11,16H2,1H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
27.5n/an/an/an/an/an/an/an/a



Development Center for Biotechnology

US Patent


Assay Description
c-KIT: Inhibition of c-KIT kinase activity by a test compound disclosed herein was estimated by radiometric assay. Standard assay conditions were 20 ...


US Patent US10689362 (2020)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM447657
PNG
(6-((3-methoxy-4-((6-methylpyridin-3-yl)methoxy)phe...)
Show SMILES COc1cc(Nc2ccc3ncc(nc3c2C(N)=O)N2CCOCC2)ccc1OCc1ccc(C)nc1
Show InChI InChI=1S/C27H28N6O4/c1-17-3-4-18(14-29-17)16-37-22-8-5-19(13-23(22)35-2)31-20-6-7-21-26(25(20)27(28)34)32-24(15-30-21)33-9-11-36-12-10-33/h3-8,13-15,31H,9-12,16H2,1-2H3,(H2,28,34)
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
27.5n/an/an/an/an/an/an/an/a



Development Center for Biotechnology

US Patent


Assay Description
c-KIT: Inhibition of c-KIT kinase activity by a test compound disclosed herein was estimated by radiometric assay. Standard assay conditions were 20 ...


US Patent US10689362 (2020)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 508 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%