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Patent code US10689367

Compile Data Set for Download or QSAR

Found 327 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Apelin receptor


(Homo sapiens (Human))
BDBM447703
PNG
(US10689367, Example 22.0)
Show SMILES CCOCCn1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)nnc1-c1cccc(OC)n1
Show InChI InChI=1S/C20H26ClN7O4S/c1-5-32-10-9-28-19(16-7-6-8-17(24-16)31-4)25-26-20(28)27-33(29,30)14(3)13(2)18-22-11-15(21)12-23-18/h6-8,11-14H,5,9-10H2,1-4H3,(H,26,27)/t13-,14-/m0/s1
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n/an/an/an/a 3.20n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10689367 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM447706
PNG
(US10689367, Example 24.0)
Show SMILES COCCn1c(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(Cl)cn2)nnc1-c1cccc(OC)n1
Show InChI InChI=1S/C21H28ClN7O5S/c1-13(2)34-18(19-23-11-15(22)12-24-19)14(3)35(30,31)28-21-27-26-20(29(21)9-10-32-4)16-7-6-8-17(25-16)33-5/h6-8,11-14,18H,9-10H2,1-5H3,(H,27,28)/t14-,18+/m0/s1
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n/an/an/an/a 0.660n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10689367 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM447712
PNG
(US10689367, Example 43.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1CCOC(F)F)c1ncc(Cl)cn1
Show InChI InChI=1S/C19H22ClF2N7O5S/c1-11(15(33-3)16-23-9-12(20)10-24-16)35(30,31)28-19-27-26-17(29(19)7-8-34-18(21)22)13-5-4-6-14(25-13)32-2/h4-6,9-11,15,18H,7-8H2,1-3H3,(H,27,28)/t11-,15-/m0/s1
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n/an/an/an/a 3.70n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10689367 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM447727
PNG
(US10689367, Example 50.0)
Show SMILES COCC1(CCC1)n1c(NS(=O)(=O)[C@@H](C)[C@H](OC)c2ncc(Cl)cn2)nnc1-c1cccc(OC)n1
Show InChI InChI=1S/C22H28ClN7O5S/c1-14(18(35-4)19-24-11-15(23)12-25-19)36(31,32)29-21-28-27-20(16-7-5-8-17(26-16)34-3)30(21)22(13-33-2)9-6-10-22/h5,7-8,11-12,14,18H,6,9-10,13H2,1-4H3,(H,28,29)/t14-,18-/m0/s1
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n/an/an/an/a 0.460n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10689367 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM447744
PNG
(US10689367, Example 63.0)
Show SMILES COCC1(CC1)n1c(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(C)cn2)nnc1-c1cncc(C)c1
Show InChI InChI=1S/C24H33N7O4S/c1-15(2)35-20(21-26-11-17(4)12-27-21)18(5)36(32,33)30-23-29-28-22(19-9-16(3)10-25-13-19)31(23)24(7-8-24)14-34-6/h9-13,15,18,20H,7-8,14H2,1-6H3,(H,29,30)/t18-,20+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10689367 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM447754
PNG
(US10689367, Example 75.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1[C@H]1CCCC[C@H]1C)c1ncc(Cl)cn1
Show InChI InChI=1S/C23H30ClN7O4S/c1-14-8-5-6-10-18(14)31-22(17-9-7-11-19(27-17)34-3)28-29-23(31)30-36(32,33)15(2)20(35-4)21-25-12-16(24)13-26-21/h7,9,11-15,18,20H,5-6,8,10H2,1-4H3,(H,29,30)/t14-,15+,18+,20+/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10689367 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM447758
PNG
(US10689367, Example 79.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1CC(C)C)c1ncc(Cl)cn1
Show InChI InChI=1S/C20H26ClN7O4S/c1-12(2)11-28-19(15-7-6-8-16(24-15)31-4)25-26-20(28)27-33(29,30)13(3)17(32-5)18-22-9-14(21)10-23-18/h6-10,12-13,17H,11H2,1-5H3,(H,26,27)/t13-,17-/m0/s1
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n/an/an/an/a<1.00E+3n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10689367 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM447776
PNG
(US10689367, Example 98.0)
Show SMILES COCC(COC)n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(C)cn2)nnc1-c1cccc(OC)n1
Show InChI InChI=1S/C22H31N7O5S/c1-14-10-23-20(24-11-14)15(2)16(3)35(30,31)28-22-27-26-21(18-8-7-9-19(25-18)34-6)29(22)17(12-32-4)13-33-5/h7-11,15-17H,12-13H2,1-6H3,(H,27,28)/t15-,16-/m0/s1
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n/an/an/an/a 6.20n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10689367 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM447780
PNG
(US10689367, Example 102.0)
Show SMILES COCC(COC)n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2cnc(C)cn2)nnc1-c1cccc(OC)n1
Show InChI InChI=1S/C22H31N7O5S/c1-14-10-24-19(11-23-14)15(2)16(3)35(30,31)28-22-27-26-21(18-8-7-9-20(25-18)34-6)29(22)17(12-32-4)13-33-5/h7-11,15-17H,12-13H2,1-6H3,(H,27,28)/t15-,16-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10689367 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM447784
PNG
(US10689367, Example 106.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1C1(CF)CC1)c1ncc(Cl)cn1
Show InChI InChI=1S/C20H23ClFN7O4S/c1-12(16(33-3)17-23-9-13(21)10-24-17)34(30,31)28-19-27-26-18(29(19)20(11-22)7-8-20)14-5-4-6-15(25-14)32-2/h4-6,9-10,12,16H,7-8,11H2,1-3H3,(H,27,28)/t12-,16-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10689367 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM447803
PNG
(US10689367, Example 128.0)
Show SMILES CC(C)O[C@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccnc2)n1C1CC1)c1ncc(Cl)cn1
Show InChI InChI=1S/C20H24ClN7O3S/c1-12(2)31-17(18-23-10-15(21)11-24-18)13(3)32(29,30)27-20-26-25-19(28(20)16-6-7-16)14-5-4-8-22-9-14/h4-5,8-13,16-17H,6-7H2,1-3H3,(H,26,27)/t13-,17+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10689367 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM447765
PNG
(US10689367, Example 136.0 | US10689367, Example 86...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2ccccn2)n1C(C)C)c1ncc(Cl)cn1
Show InChI InChI=1S/C18H22ClN7O3S/c1-11(2)26-17(14-7-5-6-8-20-14)23-24-18(26)25-30(27,28)12(3)15(29-4)16-21-9-13(19)10-22-16/h5-12,15H,1-4H3,(H,24,25)/t12-,15-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10689367 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM447827
PNG
(US10689367, Example 153.0 | US10689367, Example 15...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)n1C1C[C@]11CC1
Show InChI InChI=1S/C21H24ClN7O3S/c1-12(18-23-10-14(22)11-24-18)13(2)33(30,31)28-20-27-26-19(15-5-4-6-17(25-15)32-3)29(20)16-9-21(16)7-8-21/h4-6,10-13,16H,7-9H2,1-3H3,(H,27,28)/t12-,13-,16?/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10689367 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM447851
PNG
(US10689367, Example 179.0)
Show SMILES COC[C@H](C)n1c(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(Cl)cn2)nnc1-c1cccc(OC)n1
Show InChI InChI=1S/C22H30ClN7O5S/c1-13(2)35-19(20-24-10-16(23)11-25-20)15(4)36(31,32)29-22-28-27-21(30(22)14(3)12-33-5)17-8-7-9-18(26-17)34-6/h7-11,13-15,19H,12H2,1-6H3,(H,28,29)/t14-,15-,19+/m0/s1
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n/an/an/an/a 0.640n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10689367 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM447858
PNG
(US10689367, Example 186.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1Cc1cnoc1)c1ncc(Cl)cn1
Show InChI InChI=1S/C20H21ClN8O5S/c1-12(17(33-3)18-22-8-14(21)9-23-18)35(30,31)28-20-27-26-19(15-5-4-6-16(25-15)32-2)29(20)10-13-7-24-34-11-13/h4-9,11-12,17H,10H2,1-3H3,(H,27,28)/t12-,17-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10689367 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM447860
PNG
(US10689367, Example 188.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1Cc1cnoc1)c1cnc(C)cn1
Show InChI InChI=1S/C21H24N8O5S/c1-13-8-23-17(10-22-13)19(33-4)14(2)35(30,31)28-21-27-26-20(16-6-5-7-18(25-16)32-3)29(21)11-15-9-24-34-12-15/h5-10,12,14,19H,11H2,1-4H3,(H,27,28)/t14-,19-/m0/s1
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n/an/an/an/a 1.40E+3n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10689367 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM447865
PNG
(US10689367, Example 193.0)
Show SMILES CCc1noc(C)c1Cn1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)nnc1-c1cccc(OC)n1
Show InChI InChI=1S/C23H27ClN8O4S/c1-6-18-17(14(3)36-30-18)12-32-22(19-8-7-9-20(27-19)35-5)28-29-23(32)31-37(33,34)15(4)13(2)21-25-10-16(24)11-26-21/h7-11,13,15H,6,12H2,1-5H3,(H,29,31)/t13-,15-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10689367 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM447869
PNG
(US10689367, Example 197.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1Cc1cc(OC)no1)c1ncc(Cl)cn1
Show InChI InChI=1S/C21H23ClN8O6S/c1-12(18(35-4)19-23-9-13(22)10-24-19)37(31,32)29-21-27-26-20(15-6-5-7-16(25-15)33-2)30(21)11-14-8-17(34-3)28-36-14/h5-10,12,18H,11H2,1-4H3,(H,27,29)/t12-,18-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10689367 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM447873
PNG
(US10689367, Example 201.0 | US10689367, Example 21...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)n1[C@@H](C)c1ccno1
Show InChI InChI=1S/C21H23ClN8O4S/c1-12(19-23-10-15(22)11-24-19)14(3)35(31,32)29-21-28-27-20(16-6-5-7-18(26-16)33-4)30(21)13(2)17-8-9-25-34-17/h5-14H,1-4H3,(H,28,29)/t12-,13-,14-/m0/s1
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n/an/an/an/a 3.5n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10689367 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM447875
PNG
(US10689367, Example 203.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1Cc1cc(no1)C(F)(F)F)c1cnc(C)cn1
Show InChI InChI=1S/C22H23F3N8O5S/c1-12-9-27-16(10-26-12)19(37-4)13(2)39(34,35)32-21-30-29-20(15-6-5-7-18(28-15)36-3)33(21)11-14-8-17(31-38-14)22(23,24)25/h5-10,13,19H,11H2,1-4H3,(H,30,32)/t13-,19-/m0/s1
PDB

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n/an/an/an/a 56n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10689367 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM447880
PNG
(US10689367, Example 208.0)
Show SMILES CC[C@H](c1c(C)noc1C)n1c(NS(=O)(=O)[C@@H](C)[C@H](OC)c2cnc(C)cn2)nnc1-c1cccc(OC)n1
Show InChI InChI=1S/C25H32N8O5S/c1-8-20(22-15(3)31-38-16(22)4)33-24(18-10-9-11-21(28-18)36-6)29-30-25(33)32-39(34,35)17(5)23(37-7)19-13-26-14(2)12-27-19/h9-13,17,20,23H,8H2,1-7H3,(H,30,32)/t17-,20+,23-/m0/s1
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n/an/an/an/a 42n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10689367 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM447872
PNG
(US10689367, Example 200.0 | US10689367, Example 21...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1[C@@H](C)c1ccno1)c1ncc(Cl)cn1
Show InChI InChI=1S/C21H23ClN8O5S/c1-12(16-8-9-25-35-16)30-20(15-6-5-7-17(26-15)33-3)27-28-21(30)29-36(31,32)13(2)18(34-4)19-23-10-14(22)11-24-19/h5-13,18H,1-4H3,(H,28,29)/t12-,13-,18-/m0/s1
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n/an/an/an/a 0.850n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10689367 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM447872
PNG
(US10689367, Example 200.0 | US10689367, Example 21...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1[C@@H](C)c1ccno1)c1ncc(Cl)cn1
Show InChI InChI=1S/C21H23ClN8O5S/c1-12(16-8-9-25-35-16)30-20(15-6-5-7-17(26-15)33-3)27-28-21(30)29-36(31,32)13(2)18(34-4)19-23-10-14(22)11-24-19/h5-13,18H,1-4H3,(H,28,29)/t12-,13-,18-/m0/s1
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n/an/an/an/a 0.660n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10689367 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM447873
PNG
(US10689367, Example 201.0 | US10689367, Example 21...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)n1[C@@H](C)c1ccno1
Show InChI InChI=1S/C21H23ClN8O4S/c1-12(19-23-10-15(22)11-24-19)14(3)35(31,32)29-21-28-27-20(16-6-5-7-18(26-16)33-4)30(21)13(2)17-8-9-25-34-17/h5-14H,1-4H3,(H,28,29)/t12-,13-,14-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10689367 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM447874
PNG
(US10689367, Example 202.0 | US10689367, Example 21...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(C)cn2)n1[C@@H](C)c1ccno1
Show InChI InChI=1S/C24H30N8O5S/c1-14(2)36-21(22-25-12-15(3)13-26-22)17(5)38(33,34)31-24-30-29-23(18-8-7-9-20(28-18)35-6)32(24)16(4)19-10-11-27-37-19/h7-14,16-17,21H,1-6H3,(H,30,31)/t16-,17-,21+/m0/s1
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n/an/an/an/a 5.30n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10689367 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM447890
PNG
(US10689367, Example 218.0 | US10689367, Example 21...)
Show SMILES CC[C@@H](c1c(C)noc1C)n1c(NS(=O)(=O)[C@@H](C)[C@H](OC)c2ncc(Cl)cn2)nnc1-c1cccc(OC)n1
Show InChI InChI=1S/C24H29ClN8O5S/c1-7-18(20-13(2)31-38-14(20)3)33-23(17-9-8-10-19(28-17)36-5)29-30-24(33)32-39(34,35)15(4)21(37-6)22-26-11-16(25)12-27-22/h8-12,15,18,21H,7H2,1-6H3,(H,30,32)/t15-,18-,21-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10689367 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM447896
PNG
(US10689367, Example 224.0 | US10689367, Example 22...)
Show SMILES CC[C@@H](c1c(C)noc1C)n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)nnc1-c1cccc(OC)n1
Show InChI InChI=1S/C24H29ClN8O4S/c1-7-19(21-14(3)31-37-15(21)4)33-23(18-9-8-10-20(28-18)36-6)29-30-24(33)32-38(34,35)16(5)13(2)22-26-11-17(25)12-27-22/h8-13,16,19H,7H2,1-6H3,(H,30,32)/t13-,16-,19-/m0/s1
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n/an/an/an/a 13n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10689367 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM447899
PNG
(US10689367, Example 227.0 | US10689367, Example 23...)
Show SMILES CC[C@@H](c1conc1C)n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)nnc1-c1cccc(OC)n1
Show InChI InChI=1S/C23H27ClN8O4S/c1-6-19(17-12-36-30-14(17)3)32-22(18-8-7-9-20(27-18)35-5)28-29-23(32)31-37(33,34)15(4)13(2)21-25-10-16(24)11-26-21/h7-13,15,19H,6H2,1-5H3,(H,29,31)/t13-,15-,19-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10689367 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM447905
PNG
(US10689367, Example 233.0 | US10689367, Example 23...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(C)cn2)n1[C@@H](C)c1ncn(C)n1
Show InChI InChI=1S/C24H32N10O4S/c1-14(2)38-20(22-25-11-15(3)12-26-22)17(5)39(35,36)32-24-30-29-23(18-9-8-10-19(28-18)37-7)34(24)16(4)21-27-13-33(6)31-21/h8-14,16-17,20H,1-7H3,(H,30,32)/t16-,17-,20+/m0/s1
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n/an/an/an/a 10n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10689367 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM447909
PNG
(US10689367, Example 237.0 | US10689367, Example 23...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)n1[C@@H](C)c1ncn(C)n1
Show InChI InChI=1S/C21H25ClN10O3S/c1-12(18-23-9-15(22)10-24-18)14(3)36(33,34)30-21-28-27-20(16-7-6-8-17(26-16)35-5)32(21)13(2)19-25-11-31(4)29-19/h6-14H,1-5H3,(H,28,30)/t12-,13-,14-/m0/s1
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n/an/an/an/a 130n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10689367 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM447911
PNG
(US10689367, Example 239.0 | US10689367, Example 24...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(C)cn2)n1[C@@H](C)c1nc(C)no1
Show InChI InChI=1S/C24H31N9O5S/c1-13(2)37-20(21-25-11-14(3)12-26-21)16(5)39(34,35)32-24-30-29-22(18-9-8-10-19(28-18)36-7)33(24)15(4)23-27-17(6)31-38-23/h8-13,15-16,20H,1-7H3,(H,30,32)/t15-,16-,20+/m0/s1
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n/an/an/an/a 2.60n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10689367 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM447917
PNG
(US10689367, Example 245.0)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)n1[C@@H](C)c1noc(C)n1
Show InChI InChI=1S/C21H24ClN9O4S/c1-11(18-23-9-15(22)10-24-18)13(3)36(32,33)30-21-28-27-20(16-7-6-8-17(26-16)34-5)31(21)12(2)19-25-14(4)35-29-19/h6-13H,1-5H3,(H,28,30)/t11-,12-,13-/m0/s1
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n/an/an/an/a 7n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10689367 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM447924
PNG
(US10689367, Example 252.0 | US10689367, Example 25...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(C)cn2)n1[C@@H](C)c1ncnn1C
Show InChI InChI=1S/C24H32N10O4S/c1-14(2)38-20(21-25-11-15(3)12-26-21)17(5)39(35,36)32-24-31-30-23(18-9-8-10-19(29-18)37-7)34(24)16(4)22-27-13-28-33(22)6/h8-14,16-17,20H,1-7H3,(H,31,32)/t16-,17-,20+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10689367 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM447945
PNG
(US10689367, Example 273.0 | US10689367, Example 27...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(C)cn2)n1[C@@H](C)[C@H]1CCCO1
Show InChI InChI=1S/C25H35N7O5S/c1-15(2)37-22(23-26-13-16(3)14-27-23)18(5)38(33,34)31-25-30-29-24(19-9-7-11-21(28-19)35-6)32(25)17(4)20-10-8-12-36-20/h7,9,11,13-15,17-18,20,22H,8,10,12H2,1-6H3,(H,30,31)/t17-,18-,20+,22+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10689367 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM447945
PNG
(US10689367, Example 273.0 | US10689367, Example 27...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(C)cn2)n1[C@@H](C)[C@H]1CCCO1
Show InChI InChI=1S/C25H35N7O5S/c1-15(2)37-22(23-26-13-16(3)14-27-23)18(5)38(33,34)31-25-30-29-24(19-9-7-11-21(28-19)35-6)32(25)17(4)20-10-8-12-36-20/h7,9,11,13-15,17-18,20,22H,8,10,12H2,1-6H3,(H,30,31)/t17-,18-,20+,22+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10689367 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM447956
PNG
(US10689367, Example 284.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1CCc1cccnc1)c1ncc(Cl)cn1
Show InChI InChI=1S/C23H25ClN8O4S/c1-15(20(36-3)21-26-13-17(24)14-27-21)37(33,34)31-23-30-29-22(18-7-4-8-19(28-18)35-2)32(23)11-9-16-6-5-10-25-12-16/h4-8,10,12-15,20H,9,11H2,1-3H3,(H,30,31)/t15-,20-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10689367 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM447967
PNG
(US10689367, Example 295.0 | US10689367, Example 29...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)n1[C@H](C)c1csnn1
Show InChI InChI=1S/C20H22ClN9O3S2/c1-11(18-22-8-14(21)9-23-18)13(3)35(31,32)28-20-27-26-19(15-6-5-7-17(24-15)33-4)30(20)12(2)16-10-34-29-25-16/h5-13H,1-4H3,(H,27,28)/t11-,12+,13-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10689367 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM447977
PNG
(US10689367, Example 305.0 | US10689367, Example 30...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1C[C@@H]1CCC[C@H](C)O1)c1ncc(Cl)cn1
Show InChI InChI=1S/C23H30ClN7O5S/c1-14-7-5-8-17(36-14)13-31-22(18-9-6-10-19(27-18)34-3)28-29-23(31)30-37(32,33)15(2)20(35-4)21-25-11-16(24)12-26-21/h6,9-12,14-15,17,20H,5,7-8,13H2,1-4H3,(H,29,30)/t14-,15-,17-,20-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10689367 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM447983
PNG
(US10689367, Example 311.0 | US10689367, Example 31...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1C[C@@H]1CCCOC1)c1ncc(Cl)cn1
Show InChI InChI=1S/C22H28ClN7O5S/c1-14(19(34-3)20-24-10-16(23)11-25-20)36(31,32)29-22-28-27-21(17-7-4-8-18(26-17)33-2)30(22)12-15-6-5-9-35-13-15/h4,7-8,10-11,14-15,19H,5-6,9,12-13H2,1-3H3,(H,28,29)/t14-,15-,19-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10689367 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM447985
PNG
(US10689367, Example 313.0 | US10689367, Example 31...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)n1[C@@H](C)c1c(C)noc1C
Show InChI InChI=1S/C23H27ClN8O4S/c1-12(21-25-10-17(24)11-26-21)16(5)37(33,34)31-23-29-28-22(18-8-7-9-19(27-18)35-6)32(23)14(3)20-13(2)30-36-15(20)4/h7-12,14,16H,1-6H3,(H,29,31)/t12-,14-,16-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10689367 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM447989
PNG
(US10689367, Example 317.0 | US10689367, Example 31...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1[C@H](C)[C@@H]1CCCCO1)c1ncc(Cl)cn1
Show InChI InChI=1S/C23H30ClN7O5S/c1-14(18-9-5-6-11-36-18)31-22(17-8-7-10-19(27-17)34-3)28-29-23(31)30-37(32,33)15(2)20(35-4)21-25-12-16(24)13-26-21/h7-8,10,12-15,18,20H,5-6,9,11H2,1-4H3,(H,29,30)/t14-,15+,18+,20+/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10689367 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM447993
PNG
(US10689367, Example 321.0 | US10689367, Example 32...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(C)cn2)n1[C@H](C)[C@@H]1CCCCO1
Show InChI InChI=1S/C26H37N7O5S/c1-16(2)38-23(24-27-14-17(3)15-28-24)19(5)39(34,35)32-26-31-30-25(20-10-9-12-22(29-20)36-6)33(26)18(4)21-11-7-8-13-37-21/h9-10,12,14-16,18-19,21,23H,7-8,11,13H2,1-6H3,(H,31,32)/t18-,19+,21+,23-/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10689367 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM448001
PNG
(US10689367, Example 329.0 | US10689367, Example 33...)
Show SMILES CC[C@H]([C@@H]1CCCCO1)n1c(NS(=O)(=O)[C@@H](C)[C@H](OC)c2ncc(C)cn2)nnc1-c1cccc(OC)n1
Show InChI InChI=1S/C25H35N7O5S/c1-6-19(20-11-7-8-13-37-20)32-24(18-10-9-12-21(28-18)35-4)29-30-25(32)31-38(33,34)17(3)22(36-5)23-26-14-16(2)15-27-23/h9-10,12,14-15,17,19-20,22H,6-8,11,13H2,1-5H3,(H,30,31)/t17-,19+,20-,22-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10689367 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM448008
PNG
(US10689367, Example 336.0 | US10689367, Example 33...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1[C@H](C)c1cncnc1)c1ncc(Cl)cn1
Show InChI InChI=1S/C22H24ClN9O4S/c1-13(15-8-24-12-25-9-15)32-21(17-6-5-7-18(28-17)35-3)29-30-22(32)31-37(33,34)14(2)19(36-4)20-26-10-16(23)11-27-20/h5-14,19H,1-4H3,(H,30,31)/t13-,14+,19+/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10689367 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM448014
PNG
(US10689367, Example 342.0 | US10689367, Example 34...)
Show SMILES CC[C@H](c1cc(F)cc(F)c1)n1c(NS(=O)(=O)[C@@H](C)[C@H](OC)c2ncc(Cl)cn2)nnc1-c1cccc(OC)n1
Show InChI InChI=1S/C25H26ClF2N7O4S/c1-5-20(15-9-17(27)11-18(28)10-15)35-24(19-7-6-8-21(31-19)38-3)32-33-25(35)34-40(36,37)14(2)22(39-4)23-29-12-16(26)13-30-23/h6-14,20,22H,5H2,1-4H3,(H,33,34)/t14-,20+,22-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10689367 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM448016
PNG
(US10689367, Example 344.0 | US10689367, Example 34...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1[C@H](C)c1cscn1)c1ncc(Cl)cn1
Show InChI InChI=1S/C21H23ClN8O4S2/c1-12(16-10-35-11-25-16)30-20(15-6-5-7-17(26-15)33-3)27-28-21(30)29-36(31,32)13(2)18(34-4)19-23-8-14(22)9-24-19/h5-13,18H,1-4H3,(H,28,29)/t12-,13+,18+/m1/s1
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n/an/an/an/a 7.10n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10689367 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM448018
PNG
(US10689367, Example 346.0 | US10689367, Example 34...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1[C@H](C)c1cncs1)c1ncc(Cl)cn1
Show InChI InChI=1S/C21H23ClN8O4S2/c1-12(16-10-23-11-35-16)30-20(15-6-5-7-17(26-15)33-3)27-28-21(30)29-36(31,32)13(2)18(34-4)19-24-8-14(22)9-25-19/h5-13,18H,1-4H3,(H,28,29)/t12-,13+,18+/m1/s1
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n/an/an/an/a 0.480n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10689367 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM447681
PNG
(US10689367, Example 1.0)
Show SMILES CO[C@@H]1CCC[C@H](OC)[C@H]1n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(C)cn2)nnc1-c1cncc(C)c1
Show InChI InChI=1S/C25H35N7O4S/c1-15-10-19(14-26-11-15)24-29-30-25(32(24)22-20(35-5)8-7-9-21(22)36-6)31-37(33,34)18(4)17(3)23-27-12-16(2)13-28-23/h10-14,17-18,20-22H,7-9H2,1-6H3,(H,30,31)/t17-,18-,20-,21+,22+/m0/s1
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n/an/an/an/a 680n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10689367 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM447682
PNG
(US10689367, Example 2.0)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)n1CC1COC1
Show InChI InChI=1S/C20H24ClN7O4S/c1-12(18-22-7-15(21)8-23-18)13(2)33(29,30)27-20-26-25-19(28(20)9-14-10-32-11-14)16-5-4-6-17(24-16)31-3/h4-8,12-14H,9-11H2,1-3H3,(H,26,27)/t12-,13-/m0/s1
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n/an/an/an/a>4.20E+3n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10689367 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM447683
PNG
(US10689367, Example 3.0)
Show SMILES COCCn1c(NS(=O)(=O)[C@@H](C)[C@H](OC)c2ncc(Cl)cn2)nnc1-c1cccc(OC)n1
Show InChI InChI=1S/C19H24ClN7O5S/c1-12(16(32-4)17-21-10-13(20)11-22-17)33(28,29)26-19-25-24-18(27(19)8-9-30-2)14-6-5-7-15(23-14)31-3/h5-7,10-12,16H,8-9H2,1-4H3,(H,25,26)/t12-,16-/m0/s1
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n/an/an/an/a 2.80n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10689367 (2020)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%