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Patent code US10689376

Compile Data Set for Download or QSAR
Found 39 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1


(Homo sapiens (Human))
BDBM448056
PNG
(US10689376, Compound 78)
Show SMILES COc1ccc(NC(=O)CSc2nc3c(C)c(ncc3[nH]2)C#N)cc1O
Show InChI InChI=1S/C17H15N5O3S/c1-9-11(6-18)19-7-12-16(9)22-17(21-12)26-8-15(24)20-10-3-4-14(25-2)13(23)5-10/h3-5,7,23H,8H2,1-2H3,(H,20,24)(H,21,22)
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n/an/a 79n/an/an/an/an/an/a



Stingray Therapeutics, Inc.; The University of Utah

US Patent


Assay Description
Materials: Assay Buffer: 1 mM CaCl2, 0.2 mM ZnCl2, 50 mM Tris, pH 9.0 Substrate: 8 mM Thymidine 5′-monophosphate p-nitrophenol es...


US Patent US10689376 (2020)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1


(Homo sapiens (Human))
BDBM448030
PNG
(US10689376, Compound 21)
Show SMILES COc1ccc(NC(=O)CSc2nc3cc(Cl)ncc3[nH]2)cc1O
Show InChI InChI=1S/C15H13ClN4O3S/c1-23-12-3-2-8(4-11(12)21)18-14(22)7-24-15-19-9-5-13(16)17-6-10(9)20-15/h2-6,21H,7H2,1H3,(H,18,22)(H,19,20)
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n/an/a 86n/an/an/an/an/an/a



Stingray Therapeutics, Inc.; The University of Utah

US Patent


Assay Description
Materials: Assay Buffer: 1 mM CaCl2, 0.2 mM ZnCl2, 50 mM Tris, pH 9.0 Substrate: 8 mM Thymidine 5′-monophosphate p-nitrophenol es...


US Patent US10689376 (2020)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1


(Homo sapiens (Human))
BDBM448052
PNG
(US10689376, Compound 68)
Show SMILES COc1ccc(NC(=O)CSc2nc3cc(ncc3[nH]2)C#N)cc1OC
Show InChI InChI=1S/C17H15N5O3S/c1-24-14-4-3-10(6-15(14)25-2)20-16(23)9-26-17-21-12-5-11(7-18)19-8-13(12)22-17/h3-6,8H,9H2,1-2H3,(H,20,23)(H,21,22)
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n/an/a 114n/an/an/an/an/an/a



Stingray Therapeutics, Inc.; The University of Utah

US Patent


Assay Description
Materials: Assay Buffer: 1 mM CaCl2, 0.2 mM ZnCl2, 50 mM Tris, pH 9.0 Substrate: 8 mM Thymidine 5′-monophosphate p-nitrophenol es...


US Patent US10689376 (2020)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1


(Homo sapiens (Human))
BDBM448039
PNG
(US10689376, Compound 37)
Show SMILES Oc1cc(NC(=O)CSc2nc3cnc(Cl)cc3[nH]2)ccc1F
Show InChI InChI=1S/C14H10ClFN4O2S/c15-12-4-9-10(5-17-12)20-14(19-9)23-6-13(22)18-7-1-2-8(16)11(21)3-7/h1-5,21H,6H2,(H,18,22)(H,19,20)
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n/an/a 170n/an/an/an/an/an/a



Stingray Therapeutics, Inc.; The University of Utah

US Patent


Assay Description
Materials: Assay Buffer: 1 mM CaCl2, 0.2 mM ZnCl2, 50 mM Tris, pH 9.0 Substrate: 8 mM Thymidine 5′-monophosphate p-nitrophenol es...


US Patent US10689376 (2020)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1


(Homo sapiens (Human))
BDBM448050
PNG
(US10689376, Compound 67)
Show SMILES COc1ccc(NC(=O)CSc2nc3cc(ncc3[nH]2)C#N)cc1O
Show InChI InChI=1S/C16H13N5O3S/c1-24-14-3-2-9(5-13(14)22)19-15(23)8-25-16-20-11-4-10(6-17)18-7-12(11)21-16/h2-5,7,22H,8H2,1H3,(H,19,23)(H,20,21)
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n/an/a 179n/an/an/an/an/an/a



Stingray Therapeutics, Inc.; The University of Utah

US Patent


Assay Description
Materials: Assay Buffer: 1 mM CaCl2, 0.2 mM ZnCl2, 50 mM Tris, pH 9.0 Substrate: 8 mM Thymidine 5′-monophosphate p-nitrophenol es...


US Patent US10689376 (2020)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1


(Homo sapiens (Human))
BDBM448036
PNG
(US10689376, Compound 31)
Show SMILES COc1ccc(NC(=O)CSc2nc3cnc(cc3[nH]2)C(F)(F)F)cc1O
Show InChI InChI=1S/C16H13F3N4O3S/c1-26-12-3-2-8(4-11(12)24)21-14(25)7-27-15-22-9-5-13(16(17,18)19)20-6-10(9)23-15/h2-6,24H,7H2,1H3,(H,21,25)(H,22,23)
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n/an/a 181n/an/an/an/an/an/a



Stingray Therapeutics, Inc.; The University of Utah

US Patent


Assay Description
Materials: Assay Buffer: 1 mM CaCl2, 0.2 mM ZnCl2, 50 mM Tris, pH 9.0 Substrate: 8 mM Thymidine 5′-monophosphate p-nitrophenol es...


US Patent US10689376 (2020)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1


(Homo sapiens (Human))
BDBM448053
PNG
(US10689376, Compound 69)
Show SMILES Oc1cc(NC(=O)CSc2nc3cc(ncc3[nH]2)C#N)ccc1F
Show InChI InChI=1S/C15H10FN5O2S/c16-10-2-1-8(4-13(10)22)19-14(23)7-24-15-20-11-3-9(5-17)18-6-12(11)21-15/h1-4,6,22H,7H2,(H,19,23)(H,20,21)
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n/an/a 216n/an/an/an/an/an/a



Stingray Therapeutics, Inc.; The University of Utah

US Patent


Assay Description
Materials: Assay Buffer: 1 mM CaCl2, 0.2 mM ZnCl2, 50 mM Tris, pH 9.0 Substrate: 8 mM Thymidine 5′-monophosphate p-nitrophenol es...


US Patent US10689376 (2020)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1


(Homo sapiens (Human))
BDBM448062
PNG
(US10689376, Compound 93)
Show SMILES COc1ccc(NC(=O)CSc2nc3c(C)c(ncc3[nH]2)C#N)cc1F
Show InChI InChI=1S/C17H14FN5O2S/c1-9-12(6-19)20-7-13-16(9)23-17(22-13)26-8-15(24)21-10-3-4-14(25-2)11(18)5-10/h3-5,7H,8H2,1-2H3,(H,21,24)(H,22,23)
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n/an/a 224n/an/an/an/an/an/a



Stingray Therapeutics, Inc.; The University of Utah

US Patent


Assay Description
Materials: Assay Buffer: 1 mM CaCl2, 0.2 mM ZnCl2, 50 mM Tris, pH 9.0 Substrate: 8 mM Thymidine 5′-monophosphate p-nitrophenol es...


US Patent US10689376 (2020)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1


(Homo sapiens (Human))
BDBM448055
PNG
(US10689376, Compound 77)
Show SMILES COc1ccc(NC(=O)CSc2nc3c(C)c(ncc3[nH]2)C#N)cc1OC
Show InChI InChI=1S/C18H17N5O3S/c1-10-12(7-19)20-8-13-17(10)23-18(22-13)27-9-16(24)21-11-4-5-14(25-2)15(6-11)26-3/h4-6,8H,9H2,1-3H3,(H,21,24)(H,22,23)
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n/an/a 265n/an/an/an/an/an/a



Stingray Therapeutics, Inc.; The University of Utah

US Patent


Assay Description
Materials: Assay Buffer: 1 mM CaCl2, 0.2 mM ZnCl2, 50 mM Tris, pH 9.0 Substrate: 8 mM Thymidine 5′-monophosphate p-nitrophenol es...


US Patent US10689376 (2020)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1


(Homo sapiens (Human))
BDBM448061
PNG
(US10689376, Compound 85)
Show SMILES COc1cnc(NC(=O)CSc2nc3cc(Cl)ncc3[nH]2)cc1OC
Show InChI InChI=1S/C15H14ClN5O3S/c1-23-10-4-13(18-6-11(10)24-2)21-14(22)7-25-15-19-8-3-12(16)17-5-9(8)20-15/h3-6H,7H2,1-2H3,(H,19,20)(H,18,21,22)
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n/an/a 266n/an/an/an/an/an/a



Stingray Therapeutics, Inc.; The University of Utah

US Patent


Assay Description
Materials: Assay Buffer: 1 mM CaCl2, 0.2 mM ZnCl2, 50 mM Tris, pH 9.0 Substrate: 8 mM Thymidine 5′-monophosphate p-nitrophenol es...


US Patent US10689376 (2020)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1


(Homo sapiens (Human))
BDBM448034
PNG
(US10689376, Compound 27)
Show SMILES COc1ccc(NC(=O)CSc2nc3cnc(Cl)cc3[nH]2)cc1F
Show InChI InChI=1S/C15H12ClFN4O2S/c1-23-12-3-2-8(4-9(12)17)19-14(22)7-24-15-20-10-5-13(16)18-6-11(10)21-15/h2-6H,7H2,1H3,(H,19,22)(H,20,21)
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n/an/a 400n/an/an/an/an/an/a



Stingray Therapeutics, Inc.; The University of Utah

US Patent


Assay Description
Materials: Assay Buffer: 1 mM CaCl2, 0.2 mM ZnCl2, 50 mM Tris, pH 9.0 Substrate: 8 mM Thymidine 5′-monophosphate p-nitrophenol es...


US Patent US10689376 (2020)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1


(Homo sapiens (Human))
BDBM448040
PNG
(US10689376, Compound 38)
Show SMILES COc1ccc(NC(=O)CSc2nc3cnc(cc3[nH]2)C(F)(F)F)cc1F
Show InChI InChI=1S/C16H12F4N4O2S/c1-26-12-3-2-8(4-9(12)17)22-14(25)7-27-15-23-10-5-13(16(18,19)20)21-6-11(10)24-15/h2-6H,7H2,1H3,(H,22,25)(H,23,24)
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n/an/a 487n/an/an/an/an/an/a



Stingray Therapeutics, Inc.; The University of Utah

US Patent


Assay Description
Materials: Assay Buffer: 1 mM CaCl2, 0.2 mM ZnCl2, 50 mM Tris, pH 9.0 Substrate: 8 mM Thymidine 5′-monophosphate p-nitrophenol es...


US Patent US10689376 (2020)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1


(Homo sapiens (Human))
BDBM448024
PNG
(US10689376, Compound 3)
Show SMILES COc1ccc(NC(=O)CSc2nc3cc(Cl)ncc3[nH]2)cc1OC
Show InChI InChI=1S/C16H15ClN4O3S/c1-23-12-4-3-9(5-13(12)24-2)19-15(22)8-25-16-20-10-6-14(17)18-7-11(10)21-16/h3-7H,8H2,1-2H3,(H,19,22)(H,20,21)
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n/an/a 580n/an/an/an/an/an/a



Stingray Therapeutics, Inc.; The University of Utah

US Patent


Assay Description
Materials: Assay Buffer: 1 mM CaCl2, 0.2 mM ZnCl2, 50 mM Tris, pH 9.0 Substrate: 8 mM Thymidine 5′-monophosphate p-nitrophenol es...


US Patent US10689376 (2020)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1


(Homo sapiens (Human))
BDBM448043
PNG
(US10689376, Compound 45)
Show SMILES Oc1cc(NC(=O)CSc2nc3cnc(cc3[nH]2)C(F)(F)F)ccc1F
Show InChI InChI=1S/C15H10F4N4O2S/c16-8-2-1-7(3-11(8)24)21-13(25)6-26-14-22-9-4-12(15(17,18)19)20-5-10(9)23-14/h1-5,24H,6H2,(H,21,25)(H,22,23)
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n/an/a 651n/an/an/an/an/an/a



Stingray Therapeutics, Inc.; The University of Utah

US Patent


Assay Description
Materials: Assay Buffer: 1 mM CaCl2, 0.2 mM ZnCl2, 50 mM Tris, pH 9.0 Substrate: 8 mM Thymidine 5′-monophosphate p-nitrophenol es...


US Patent US10689376 (2020)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1


(Homo sapiens (Human))
BDBM448045
PNG
(US10689376, Compound 49)
Show SMILES COc1ccc(NC(=O)CSc2nc3cnc(Cl)c(C)c3[nH]2)cc1O
Show InChI InChI=1S/C16H15ClN4O3S/c1-8-14-10(6-18-15(8)17)20-16(21-14)25-7-13(23)19-9-3-4-12(24-2)11(22)5-9/h3-6,22H,7H2,1-2H3,(H,19,23)(H,20,21)
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n/an/a 667n/an/an/an/an/an/a



Stingray Therapeutics, Inc.; The University of Utah

US Patent


Assay Description
Materials: Assay Buffer: 1 mM CaCl2, 0.2 mM ZnCl2, 50 mM Tris, pH 9.0 Substrate: 8 mM Thymidine 5′-monophosphate p-nitrophenol es...


US Patent US10689376 (2020)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1


(Homo sapiens (Human))
BDBM448048
PNG
(US10689376, Compound 52)
Show SMILES COc1ccc(NC(=O)CSc2nc3cnc(Cl)c(C)c3[nH]2)cc1OC
Show InChI InChI=1S/C17H17ClN4O3S/c1-9-15-11(7-19-16(9)18)21-17(22-15)26-8-14(23)20-10-4-5-12(24-2)13(6-10)25-3/h4-7H,8H2,1-3H3,(H,20,23)(H,21,22)
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n/an/a 1.14E+3n/an/an/an/an/an/a



Stingray Therapeutics, Inc.; The University of Utah

US Patent


Assay Description
Materials: Assay Buffer: 1 mM CaCl2, 0.2 mM ZnCl2, 50 mM Tris, pH 9.0 Substrate: 8 mM Thymidine 5′-monophosphate p-nitrophenol es...


US Patent US10689376 (2020)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1


(Homo sapiens (Human))
BDBM448031
PNG
(US10689376, Compound 22)
Show SMILES COc1cc(NC(=O)CSc2nc3cc(Cl)ncc3[nH]2)ccc1O
Show InChI InChI=1S/C15H13ClN4O3S/c1-23-12-4-8(2-3-11(12)21)18-14(22)7-24-15-19-9-5-13(16)17-6-10(9)20-15/h2-6,21H,7H2,1H3,(H,18,22)(H,19,20)
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n/an/a 1.16E+3n/an/an/an/an/an/a



Stingray Therapeutics, Inc.; The University of Utah

US Patent


Assay Description
Materials: Assay Buffer: 1 mM CaCl2, 0.2 mM ZnCl2, 50 mM Tris, pH 9.0 Substrate: 8 mM Thymidine 5′-monophosphate p-nitrophenol es...


US Patent US10689376 (2020)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1


(Homo sapiens (Human))
BDBM448035
PNG
(US10689376, Compound 29)
Show SMILES COc1cc(NC(=O)CSc2nc3cc(Cl)ncc3[nH]2)ccc1OC(F)F
Show InChI InChI=1S/C16H13ClF2N4O3S/c1-25-12-4-8(2-3-11(12)26-15(18)19)21-14(24)7-27-16-22-9-5-13(17)20-6-10(9)23-16/h2-6,15H,7H2,1H3,(H,21,24)(H,22,23)
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n/an/a 1.16E+3n/an/an/an/an/an/a



Stingray Therapeutics, Inc.; The University of Utah

US Patent


Assay Description
Materials: Assay Buffer: 1 mM CaCl2, 0.2 mM ZnCl2, 50 mM Tris, pH 9.0 Substrate: 8 mM Thymidine 5′-monophosphate p-nitrophenol es...


US Patent US10689376 (2020)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1


(Homo sapiens (Human))
BDBM448047
PNG
(US10689376, Compound 51)
Show SMILES Cc1c(Cl)ncc2nc(SCC(=O)Nc3ccc(F)c(O)c3)[nH]c12
Show InChI InChI=1S/C15H12ClFN4O2S/c1-7-13-10(5-18-14(7)16)20-15(21-13)24-6-12(23)19-8-2-3-9(17)11(22)4-8/h2-5,22H,6H2,1H3,(H,19,23)(H,20,21)
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n/an/a 1.27E+3n/an/an/an/an/an/a



Stingray Therapeutics, Inc.; The University of Utah

US Patent


Assay Description
Materials: Assay Buffer: 1 mM CaCl2, 0.2 mM ZnCl2, 50 mM Tris, pH 9.0 Substrate: 8 mM Thymidine 5′-monophosphate p-nitrophenol es...


US Patent US10689376 (2020)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1


(Homo sapiens (Human))
BDBM448063
PNG
(US10689376, Compound 87)
Show SMILES COc1ccc(NC(=O)CSc2nc3cc(Cl)ncc3[nH]2)nc1OC
Show InChI InChI=1S/C15H14ClN5O3S/c1-23-10-3-4-12(21-14(10)24-2)20-13(22)7-25-15-18-8-5-11(16)17-6-9(8)19-15/h3-6H,7H2,1-2H3,(H,18,19)(H,20,21,22)
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n/an/a 1.98E+3n/an/an/an/an/an/a



Stingray Therapeutics, Inc.; The University of Utah

US Patent


Assay Description
Materials: Assay Buffer: 1 mM CaCl2, 0.2 mM ZnCl2, 50 mM Tris, pH 9.0 Substrate: 8 mM Thymidine 5′-monophosphate p-nitrophenol es...


US Patent US10689376 (2020)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1


(Homo sapiens (Human))
BDBM448065
PNG
(US10689376, Compound 96)
Show SMILES COc1nc(NC(=O)CSc2nc3c(C)c(Cl)ncc3[nH]2)ccc1O
Show InChI InChI=1S/C15H14ClN5O3S/c1-7-12-8(5-17-13(7)16)18-15(21-12)25-6-11(23)19-10-4-3-9(22)14(20-10)24-2/h3-5,22H,6H2,1-2H3,(H,18,21)(H,19,20,23)
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n/an/a 2.06E+3n/an/an/an/an/an/a



Stingray Therapeutics, Inc.; The University of Utah

US Patent


Assay Description
Materials: Assay Buffer: 1 mM CaCl2, 0.2 mM ZnCl2, 50 mM Tris, pH 9.0 Substrate: 8 mM Thymidine 5′-monophosphate p-nitrophenol es...


US Patent US10689376 (2020)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1


(Homo sapiens (Human))
BDBM448057
PNG
(US10689376, Compound 72)
Show SMILES COc1ccc(NC(=O)CSc2nc3cc(Cl)ncc3[nH]2)cn1
Show InChI InChI=1S/C14H12ClN5O2S/c1-22-13-3-2-8(5-17-13)18-12(21)7-23-14-19-9-4-11(15)16-6-10(9)20-14/h2-6H,7H2,1H3,(H,18,21)(H,19,20)
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n/an/a 3.30E+3n/an/an/an/an/an/a



Stingray Therapeutics, Inc.; The University of Utah

US Patent


Assay Description
Materials: Assay Buffer: 1 mM CaCl2, 0.2 mM ZnCl2, 50 mM Tris, pH 9.0 Substrate: 8 mM Thymidine 5′-monophosphate p-nitrophenol es...


US Patent US10689376 (2020)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1


(Homo sapiens (Human))
BDBM448027
PNG
(US10689376, Compound 14)
Show SMILES COc1ccc(NC(=O)C(C)Sc2nc3cnc(Cl)cc3[nH]2)cc1OC
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n/an/a 3.52E+3n/an/an/an/an/an/a



Stingray Therapeutics, Inc.; The University of Utah

US Patent


Assay Description
Materials: Assay Buffer: 1 mM CaCl2, 0.2 mM ZnCl2, 50 mM Tris, pH 9.0 Substrate: 8 mM Thymidine 5′-monophosphate p-nitrophenol es...


US Patent US10689376 (2020)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1


(Homo sapiens (Human))
BDBM448059
PNG
(US10689376, Compound 83)
Show SMILES COc1ccc(NC(=O)CSc2nc3cc(Cl)ncc3[nH]2)cc1[N+]([O-])=O
Show InChI InChI=1S/C15H12ClN5O4S/c1-25-12-3-2-8(4-11(12)21(23)24)18-14(22)7-26-15-19-9-5-13(16)17-6-10(9)20-15/h2-6H,7H2,1H3,(H,18,22)(H,19,20)
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n/an/a 4.55E+3n/an/an/an/an/an/a



Stingray Therapeutics, Inc.; The University of Utah

US Patent


Assay Description
Materials: Assay Buffer: 1 mM CaCl2, 0.2 mM ZnCl2, 50 mM Tris, pH 9.0 Substrate: 8 mM Thymidine 5′-monophosphate p-nitrophenol es...


US Patent US10689376 (2020)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1


(Homo sapiens (Human))
BDBM448046
PNG
(US10689376, Compound 50)
Show SMILES COc1ccc(NC(=O)CSc2nc3cnc(Cl)c(C)c3[nH]2)cc1F
Show InChI InChI=1S/C16H14ClFN4O2S/c1-8-14-11(6-19-15(8)17)21-16(22-14)25-7-13(23)20-9-3-4-12(24-2)10(18)5-9/h3-6H,7H2,1-2H3,(H,20,23)(H,21,22)
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n/an/a 5.63E+3n/an/an/an/an/an/a



Stingray Therapeutics, Inc.; The University of Utah

US Patent


Assay Description
Materials: Assay Buffer: 1 mM CaCl2, 0.2 mM ZnCl2, 50 mM Tris, pH 9.0 Substrate: 8 mM Thymidine 5′-monophosphate p-nitrophenol es...


US Patent US10689376 (2020)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1


(Homo sapiens (Human))
BDBM448051
PNG
(US10689376, Compound 54)
Show SMILES COc1cc2nc(NC(=O)CSc3nc4cc(Cl)ncc4[nH]3)sc2cc1OC
Show InChI InChI=1S/C17H14ClN5O3S2/c1-25-11-3-9-13(5-12(11)26-2)28-17(21-9)23-15(24)7-27-16-20-8-4-14(18)19-6-10(8)22-16/h3-6H,7H2,1-2H3,(H,20,22)(H,21,23,24)
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n/an/a 5.73E+3n/an/an/an/an/an/a



Stingray Therapeutics, Inc.; The University of Utah

US Patent


Assay Description
Materials: Assay Buffer: 1 mM CaCl2, 0.2 mM ZnCl2, 50 mM Tris, pH 9.0 Substrate: 8 mM Thymidine 5′-monophosphate p-nitrophenol es...


US Patent US10689376 (2020)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1


(Homo sapiens (Human))
BDBM448058
PNG
(US10689376, Compound 82)
Show SMILES COc1ccc(NC(=O)CSc2nc3cc(Cl)ncc3[nH]2)cc1N
Show InChI InChI=1S/C15H14ClN5O2S/c1-23-12-3-2-8(4-9(12)17)19-14(22)7-24-15-20-10-5-13(16)18-6-11(10)21-15/h2-6H,7,17H2,1H3,(H,19,22)(H,20,21)
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n/an/a 6.02E+3n/an/an/an/an/an/a



Stingray Therapeutics, Inc.; The University of Utah

US Patent


Assay Description
Materials: Assay Buffer: 1 mM CaCl2, 0.2 mM ZnCl2, 50 mM Tris, pH 9.0 Substrate: 8 mM Thymidine 5′-monophosphate p-nitrophenol es...


US Patent US10689376 (2020)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1


(Homo sapiens (Human))
BDBM448060
PNG
(US10689376, Compound 79)
Show SMILES Cc1c(ncc2[nH]c(SCC(=O)Nc3ccc(F)c(O)c3)nc12)C#N
Show InChI InChI=1S/C16H12FN5O2S/c1-8-11(5-18)19-6-12-15(8)22-16(21-12)25-7-14(24)20-9-2-3-10(17)13(23)4-9/h2-4,6,23H,7H2,1H3,(H,20,24)(H,21,22)
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n/an/a 6.52E+3n/an/an/an/an/an/a



Stingray Therapeutics, Inc.; The University of Utah

US Patent


Assay Description
Materials: Assay Buffer: 1 mM CaCl2, 0.2 mM ZnCl2, 50 mM Tris, pH 9.0 Substrate: 8 mM Thymidine 5′-monophosphate p-nitrophenol es...


US Patent US10689376 (2020)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1


(Homo sapiens (Human))
BDBM448037
PNG
(US10689376, Compound 33)
Show SMILES Oc1ccc(NC(=O)CSc2nc3cnc(Cl)cc3[nH]2)cc1
Show InChI InChI=1S/C14H11ClN4O2S/c15-12-5-10-11(6-16-12)19-14(18-10)22-7-13(21)17-8-1-3-9(20)4-2-8/h1-6,20H,7H2,(H,17,21)(H,18,19)
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n/an/a 7.92E+3n/an/an/an/an/an/a



Stingray Therapeutics, Inc.; The University of Utah

US Patent


Assay Description
Materials: Assay Buffer: 1 mM CaCl2, 0.2 mM ZnCl2, 50 mM Tris, pH 9.0 Substrate: 8 mM Thymidine 5′-monophosphate p-nitrophenol es...


US Patent US10689376 (2020)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1


(Homo sapiens (Human))
BDBM448032
PNG
(US10689376, Compound 25)
Show SMILES Oc1cccc(NC(=O)CSc2nc3cnc(Cl)cc3[nH]2)c1
Show InChI InChI=1S/C14H11ClN4O2S/c15-12-5-10-11(6-16-12)19-14(18-10)22-7-13(21)17-8-2-1-3-9(20)4-8/h1-6,20H,7H2,(H,17,21)(H,18,19)
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n/an/a 7.93E+3n/an/an/an/an/an/a



Stingray Therapeutics, Inc.; The University of Utah

US Patent


Assay Description
Materials: Assay Buffer: 1 mM CaCl2, 0.2 mM ZnCl2, 50 mM Tris, pH 9.0 Substrate: 8 mM Thymidine 5′-monophosphate p-nitrophenol es...


US Patent US10689376 (2020)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1


(Homo sapiens (Human))
BDBM448042
PNG
(US10689376, Compound 44)
Show SMILES COc1c(F)cc(NC(=O)CSc2nc3cnc(cc3[nH]2)C(F)(F)F)cc1F
Show InChI InChI=1S/C16H11F5N4O2S/c1-27-14-8(17)2-7(3-9(14)18)23-13(26)6-28-15-24-10-4-12(16(19,20)21)22-5-11(10)25-15/h2-5H,6H2,1H3,(H,23,26)(H,24,25)
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n/an/a 1.02E+4n/an/an/an/an/an/a



Stingray Therapeutics, Inc.; The University of Utah

US Patent


Assay Description
Materials: Assay Buffer: 1 mM CaCl2, 0.2 mM ZnCl2, 50 mM Tris, pH 9.0 Substrate: 8 mM Thymidine 5′-monophosphate p-nitrophenol es...


US Patent US10689376 (2020)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1


(Homo sapiens (Human))
BDBM448049
PNG
(US10689376, Compound 62)
Show SMILES Clc1cc2nc(SCC(=O)Nc3nc4ccccc4s3)[nH]c2cn1
Show InChI InChI=1S/C15H10ClN5OS2/c16-12-5-9-10(6-17-12)20-14(19-9)23-7-13(22)21-15-18-8-3-1-2-4-11(8)24-15/h1-6H,7H2,(H,19,20)(H,18,21,22)
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n/an/a 1.09E+4n/an/an/an/an/an/a



Stingray Therapeutics, Inc.; The University of Utah

US Patent


Assay Description
Materials: Assay Buffer: 1 mM CaCl2, 0.2 mM ZnCl2, 50 mM Tris, pH 9.0 Substrate: 8 mM Thymidine 5′-monophosphate p-nitrophenol es...


US Patent US10689376 (2020)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1


(Homo sapiens (Human))
BDBM448064
PNG
(US10689376, Compound 89)
Show SMILES COc1ccc(NC(=O)CSc2nc3cc(Cl)ncc3[nH]2)cc1OCC(F)(F)F
Show InChI InChI=1S/C17H14ClF3N4O3S/c1-27-12-3-2-9(4-13(12)28-8-17(19,20)21)23-15(26)7-29-16-24-10-5-14(18)22-6-11(10)25-16/h2-6H,7-8H2,1H3,(H,23,26)(H,24,25)
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n/an/a 1.13E+4n/an/an/an/an/an/a



Stingray Therapeutics, Inc.; The University of Utah

US Patent


Assay Description
Materials: Assay Buffer: 1 mM CaCl2, 0.2 mM ZnCl2, 50 mM Tris, pH 9.0 Substrate: 8 mM Thymidine 5′-monophosphate p-nitrophenol es...


US Patent US10689376 (2020)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1


(Homo sapiens (Human))
BDBM448041
PNG
(US10689376, Compound 42)
Show SMILES COc1ccc(NC(=O)C(C)Sc2nc3cnc(cc3[nH]2)C(F)(F)F)cc1O
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n/an/a 1.14E+4n/an/an/an/an/an/a



Stingray Therapeutics, Inc.; The University of Utah

US Patent


Assay Description
Materials: Assay Buffer: 1 mM CaCl2, 0.2 mM ZnCl2, 50 mM Tris, pH 9.0 Substrate: 8 mM Thymidine 5′-monophosphate p-nitrophenol es...


US Patent US10689376 (2020)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1


(Homo sapiens (Human))
BDBM448044
PNG
(US10689376, Compound 61)
Show SMILES Oc1cc(NC(=O)CSc2nc3cc(ncc3[nH]2)C(F)(F)F)ccc1OC(F)(F)F
Show InChI InChI=1S/C16H10F6N4O3S/c17-15(18,19)12-4-8-9(5-23-12)26-14(25-8)30-6-13(28)24-7-1-2-11(10(27)3-7)29-16(20,21)22/h1-5,27H,6H2,(H,24,28)(H,25,26)
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n/an/a 2.26E+4n/an/an/an/an/an/a



Stingray Therapeutics, Inc.; The University of Utah

US Patent


Assay Description
Materials: Assay Buffer: 1 mM CaCl2, 0.2 mM ZnCl2, 50 mM Tris, pH 9.0 Substrate: 8 mM Thymidine 5′-monophosphate p-nitrophenol es...


US Patent US10689376 (2020)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1


(Homo sapiens (Human))
BDBM448054
PNG
(US10689376, Compound 70)
Show SMILES COc1ccc(NC(=O)CS(=O)(=O)c2nc3cnc(Cl)cc3[nH]2)cc1F
Show InChI InChI=1S/C15H12ClFN4O4S/c1-25-12-3-2-8(4-9(12)17)19-14(22)7-26(23,24)15-20-10-5-13(16)18-6-11(10)21-15/h2-6H,7H2,1H3,(H,19,22)(H,20,21)
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n/an/a 3.02E+4n/an/an/an/an/an/a



Stingray Therapeutics, Inc.; The University of Utah

US Patent


Assay Description
Materials: Assay Buffer: 1 mM CaCl2, 0.2 mM ZnCl2, 50 mM Tris, pH 9.0 Substrate: 8 mM Thymidine 5′-monophosphate p-nitrophenol es...


US Patent US10689376 (2020)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1


(Homo sapiens (Human))
BDBM448033
PNG
(US10689376, Compound 40)
Show SMILES FC(F)Oc1ccc(NC(=O)CSc2nc3cc(Cl)ncc3[nH]2)cc1
Show InChI InChI=1S/C15H11ClF2N4O2S/c16-12-5-10-11(6-19-12)22-15(21-10)25-7-13(23)20-8-1-3-9(4-2-8)24-14(17)18/h1-6,14H,7H2,(H,20,23)(H,21,22)
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n/an/a 3.36E+4n/an/an/an/an/an/a



Stingray Therapeutics, Inc.; The University of Utah

US Patent


Assay Description
Materials: Assay Buffer: 1 mM CaCl2, 0.2 mM ZnCl2, 50 mM Tris, pH 9.0 Substrate: 8 mM Thymidine 5′-monophosphate p-nitrophenol es...


US Patent US10689376 (2020)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1


(Homo sapiens (Human))
BDBM448038
PNG
(US10689376, Compound 35)
Show SMILES COc1ccc(NC(=O)CSc2nc3cnc(Cl)cc3[nH]2)cc1OC(F)(F)F
Show InChI InChI=1S/C16H12ClF3N4O3S/c1-26-11-3-2-8(4-12(11)27-16(18,19)20)22-14(25)7-28-15-23-9-5-13(17)21-6-10(9)24-15/h2-6H,7H2,1H3,(H,22,25)(H,23,24)
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n/an/a 4.07E+4n/an/an/an/an/an/a



Stingray Therapeutics, Inc.; The University of Utah

US Patent


Assay Description
Materials: Assay Buffer: 1 mM CaCl2, 0.2 mM ZnCl2, 50 mM Tris, pH 9.0 Substrate: 8 mM Thymidine 5′-monophosphate p-nitrophenol es...


US Patent US10689376 (2020)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1


(Homo sapiens (Human))
BDBM448025
PNG
(US10689376, Compound 7)
Show SMILES Clc1cc2nc(SCC(=O)Nc3ccc4OCOc4c3)[nH]c2cn1
Show InChI InChI=1S/C15H11ClN4O3S/c16-13-4-9-10(5-17-13)20-15(19-9)24-6-14(21)18-8-1-2-11-12(3-8)23-7-22-11/h1-5H,6-7H2,(H,18,21)(H,19,20)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Stingray Therapeutics, Inc.; The University of Utah

US Patent


Assay Description
Materials: Assay Buffer: 1 mM CaCl2, 0.2 mM ZnCl2, 50 mM Tris, pH 9.0 Substrate: 8 mM Thymidine 5′-monophosphate p-nitrophenol es...


US Patent US10689376 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%