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Patent code US10695337

Compile Data Set for Download or QSAR

Found 794 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400377
PNG
(US10695337, Example 131 | US9999619, Example 132)
Show SMILES Fc1cc(ccc1-c1cccc2ccncc12)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C35H30FN9O/c36-31-16-24(4-5-28(31)27-3-1-2-23-6-12-38-18-30(23)27)34(46)43-14-8-26(9-15-43)44-20-35(21-44,10-11-37)45-19-25(17-42-45)32-29-7-13-39-33(29)41-22-40-32/h1-7,12-13,16-19,22,26H,8-10,14-15,20-21H2,(H,39,40,41)
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM246868
PNG
(US10053465, 7 | US10065963, Compound 7 | US1012515...)
Show SMILES Fc1c(ccnc1C(F)(F)F)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C26H23F4N9O/c27-20-18(1-7-32-22(20)26(28,29)30)24(40)37-9-3-17(4-10-37)38-13-25(14-38,5-6-31)39-12-16(11-36-39)21-19-2-8-33-23(19)35-15-34-21/h1-2,7-8,11-12,15,17H,3-5,9-10,13-14H2,(H,33,34,35)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400403
PNG
(US10695337, Example 158 | US9999619, Example 158)
Show SMILES FC(F)(F)Oc1ccccc1NC(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C27H26F3N9O2/c28-27(29,30)41-22-4-2-1-3-21(22)36-25(40)37-11-6-19(7-12-37)38-15-26(16-38,8-9-31)39-14-18(13-35-39)23-20-5-10-32-24(20)34-17-33-23/h1-5,10,13-14,17,19H,6-8,11-12,15-16H2,(H,36,40)(H,32,33,34)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400409
PNG
(US10695337, Example 164 | US9999619, Example 164)
Show SMILES FC(F)Oc1ccccc1NC(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C27H27F2N9O2/c28-25(29)40-22-4-2-1-3-21(22)35-26(39)36-11-6-19(7-12-36)37-15-27(16-37,8-9-30)38-14-18(13-34-38)23-20-5-10-31-24(20)33-17-32-23/h1-5,10,13-14,17,19,25H,6-8,11-12,15-16H2,(H,35,39)(H,31,32,33)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM448610
PNG
(4-{3-(cyanomethyl)-3-[4-(7H-pyrrolo[2,3- d]pyrimid...)
Show SMILES FC1C=C(NC(=O)N2CCCCC2)C=CC1(F)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
PDB

GoogleScholar
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400422
PNG
(US10695337, Example 177 | US9999619, Example 177)
Show SMILES Fc1c(Cl)cccc1NC(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C26H25ClFN9O/c27-20-2-1-3-21(22(20)28)34-25(38)35-10-5-18(6-11-35)36-14-26(15-36,7-8-29)37-13-17(12-33-37)23-19-4-9-30-24(19)32-16-31-23/h1-4,9,12-13,16,18H,5-7,10-11,14-15H2,(H,34,38)(H,30,31,32)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400439
PNG
(US10695337, Example 194 | US9999619, Example 194)
Show SMILES Cn1c(NC(=O)N2CCC(CC2)N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)nc2ccccc12
Show InChI InChI=1S/C28H29N11O/c1-36-23-5-3-2-4-22(23)34-26(36)35-27(40)37-12-7-20(8-13-37)38-16-28(17-38,9-10-29)39-15-19(14-33-39)24-21-6-11-30-25(21)32-18-31-24/h2-6,11,14-15,18,20H,7-9,12-13,16-17H2,1H3,(H,30,31,32)(H,34,35,40)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400472
PNG
(US10695337, Example 227 | US9999619, Example 227)
Show SMILES Fc1cccc(Cl)c1CN1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C26H26ClFN8/c27-22-2-1-3-23(28)21(22)14-34-10-5-19(6-11-34)35-15-26(16-35,7-8-29)36-13-18(12-33-36)24-20-4-9-30-25(20)32-17-31-24/h1-4,9,12-13,17,19H,5-7,10-11,14-16H2,(H,30,31,32)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400481
PNG
(US10695337, Example 236 | US9999619, Example 236)
Show SMILES Fc1c(Cl)ccc(c1CN1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12)C(F)(F)F
Show InChI InChI=1S/C27H25ClF4N8/c28-22-2-1-21(27(30,31)32)20(23(22)29)13-38-9-4-18(5-10-38)39-14-26(15-39,6-7-33)40-12-17(11-37-40)24-19-3-8-34-25(19)36-16-35-24/h1-3,8,11-12,16,18H,4-6,9-10,13-15H2,(H,34,35,36)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400520
PNG
(US10695337, Example 276 | US9999619, Example 276)
Show SMILES Fc1cccc(C(=O)N2CCC(CC2)N2CC(CC#N)(C2)n2ccc(c2)-c2ncnc3[nH]ccc23)c1F
Show InChI InChI=1S/C27H25F2N7O/c28-22-3-1-2-20(23(22)29)26(37)34-11-6-19(7-12-34)35-15-27(16-35,8-9-30)36-13-5-18(14-36)24-21-4-10-31-25(21)33-17-32-24/h1-5,10,13-14,17,19H,6-8,11-12,15-16H2,(H,31,32,33)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400537
PNG
(US10695337, Example 293 | US9999619, Example 293)
Show SMILES Clc1ccc(NC(=O)N2CCC(CC2)N2CC(CC#N)(C2)n2ccc(c2)-c2ncnc3[nH]ccc23)c(c1)C#N
Show InChI InChI=1S/C28H26ClN9O/c29-21-1-2-24(20(13-21)14-31)35-27(39)36-10-5-22(6-11-36)37-16-28(17-37,7-8-30)38-12-4-19(15-38)25-23-3-9-32-26(23)34-18-33-25/h1-4,9,12-13,15,18,22H,5-7,10-11,16-17H2,(H,35,39)(H,32,33,34)
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400557
PNG
(US10695337, Example 313 | US9999619, Example 313)
Show SMILES Clc1cc(ccc1NC(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ccnc2[nH]ccc12)C#N
Show InChI InChI=1S/C28H26ClN9O/c29-24-13-19(14-31)1-2-25(24)35-27(39)36-11-5-21(6-12-36)37-17-28(18-37,7-8-30)38-16-20(15-34-38)22-3-9-32-26-23(22)4-10-33-26/h1-4,9-10,13,15-16,21H,5-7,11-12,17-18H2,(H,32,33)(H,35,39)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400568
PNG
(US10695337, Example 324 | US9999619, Example 324)
Show SMILES Fc1cnc2[nH]ccc2c1-c1cnn(c1)C1(CC#N)CN(C1)C1CCN(CC1)C(=O)c1cc(ccc1C#N)C#N
Show InChI InChI=1S/C29H24FN9O/c30-25-15-35-27-23(3-8-34-27)26(25)21-14-36-39(16-21)29(6-7-31)17-38(18-29)22-4-9-37(10-5-22)28(40)24-11-19(12-32)1-2-20(24)13-33/h1-3,8,11,14-16,22H,4-6,9-10,17-18H2,(H,34,35)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM246868
PNG
(US10053465, 7 | US10065963, Compound 7 | US1012515...)
Show SMILES Fc1c(ccnc1C(F)(F)F)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C26H23F4N9O/c27-20-18(1-7-32-22(20)26(28,29)30)24(40)37-9-3-17(4-10-37)38-13-25(14-38,5-6-31)39-12-16(11-36-39)21-19-2-8-33-23(19)35-15-34-21/h1-2,7-8,11-12,15,17H,3-5,9-10,13-14H2,(H,33,34,35)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400610
PNG
(US10695337, Example 366 | US9999619, Example 366 |...)
Show SMILES CN(C)Cc1cc(nc(c1)C(F)(F)F)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C29H31F3N10O/c1-39(2)14-19-11-23(38-24(12-19)29(30,31)32)27(43)40-9-4-21(5-10-40)41-16-28(17-41,6-7-33)42-15-20(13-37-42)25-22-3-8-34-26(22)36-18-35-25/h3,8,11-13,15,18,21H,4-6,9-10,14,16-17H2,1-2H3,(H,34,35,36)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400619
PNG
(US10695337, Example 375 | US9999619, Example 375 |...)
Show SMILES CN(C)Cc1cc(cc(c1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12)C(F)F
Show InChI InChI=1S/C30H33F2N9O/c1-38(2)15-20-11-21(27(31)32)13-22(12-20)29(42)39-9-4-24(5-10-39)40-17-30(18-40,6-7-33)41-16-23(14-37-41)26-25-3-8-34-28(25)36-19-35-26/h3,8,11-14,16,19,24,27H,4-6,9-10,15,17-18H2,1-2H3,(H,34,35,36)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400634
PNG
(US10695337, Example 390 | US9999619, Example 390 |...)
Show SMILES CC(C)COC(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C24H30N8O2/c1-17(2)13-34-23(33)30-9-4-19(5-10-30)31-14-24(15-31,6-7-25)32-12-18(11-29-32)21-20-3-8-26-22(20)28-16-27-21/h3,8,11-12,16-17,19H,4-6,9-10,13-15H2,1-2H3,(H,26,27,28)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400265
PNG
(US10695337, Example 20 | US9999619, Example 21)
Show SMILES Brc1cccc(c1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C26H25BrN8O/c27-20-3-1-2-18(12-20)25(36)33-10-5-21(6-11-33)34-15-26(16-34,7-8-28)35-14-19(13-32-35)23-22-4-9-29-24(22)31-17-30-23/h1-4,9,12-14,17,21H,5-7,10-11,15-16H2,(H,29,30,31)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400290
PNG
(US10695337, Example 44 | US9999619, Example 45)
Show SMILES Fc1cccc(F)c1C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C26H24F2N8O/c27-20-2-1-3-21(28)22(20)25(37)34-10-5-18(6-11-34)35-14-26(15-35,7-8-29)36-13-17(12-33-36)23-19-4-9-30-24(19)32-16-31-23/h1-4,9,12-13,16,18H,5-7,10-11,14-15H2,(H,30,31,32)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400292
PNG
(US10695337, Example 46 | US9999619, Example 47)
Show SMILES Fc1ccc(C(=O)N2CCC(CC2)N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)c(F)c1F
Show InChI InChI=1S/C26H23F3N8O/c27-20-2-1-18(21(28)22(20)29)25(38)35-9-4-17(5-10-35)36-13-26(14-36,6-7-30)37-12-16(11-34-37)23-19-3-8-31-24(19)33-15-32-23/h1-3,8,11-12,15,17H,4-6,9-10,13-14H2,(H,31,32,33)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400309
PNG
(US10695337, Example 63 | US9999619, Example 64)
Show SMILES Fc1cc(ccc1Cl)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C26H24ClFN8O/c27-21-2-1-17(11-22(21)28)25(37)34-9-4-19(5-10-34)35-14-26(15-35,6-7-29)36-13-18(12-33-36)23-20-3-8-30-24(20)32-16-31-23/h1-3,8,11-13,16,19H,4-6,9-10,14-15H2,(H,30,31,32)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400325
PNG
(US10695337, Example 79 | US9999619, Example 80)
Show SMILES Cc1csc(c1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C25H26N8OS/c1-17-10-21(35-13-17)24(34)31-8-3-19(4-9-31)32-14-25(15-32,5-6-26)33-12-18(11-30-33)22-20-2-7-27-23(20)29-16-28-22/h2,7,10-13,16,19H,3-5,8-9,14-15H2,1H3,(H,27,28,29)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400329
PNG
(US10695337, Example 83 | US9999619, Example 84)
Show SMILES Fc1cc(cc(F)c1C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12)C#N
Show InChI InChI=1S/C27H23F2N9O/c28-21-9-17(11-31)10-22(29)23(21)26(39)36-7-2-19(3-8-36)37-14-27(15-37,4-5-30)38-13-18(12-35-38)24-20-1-6-32-25(20)34-16-33-24/h1,6,9-10,12-13,16,19H,2-4,7-8,14-15H2,(H,32,33,34)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400336
PNG
(US10695337, Example 90 | US9999619, Example 91)
Show SMILES O=C(N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12)c1cc2ccccc2s1
Show InChI InChI=1S/C28H26N8OS/c29-9-8-28(36-15-20(14-33-36)25-22-5-10-30-26(22)32-18-31-25)16-35(17-28)21-6-11-34(12-7-21)27(37)24-13-19-3-1-2-4-23(19)38-24/h1-5,10,13-15,18,21H,6-8,11-12,16-17H2,(H,30,31,32)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400337
PNG
(US10695337, Example 91 | US9999619, Example 92)
Show SMILES Fc1ccc2c(Cl)c(sc2c1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C28H24ClFN8OS/c29-23-20-2-1-18(30)11-22(20)40-25(23)27(39)36-9-4-19(5-10-36)37-14-28(15-37,6-7-31)38-13-17(12-35-38)24-21-3-8-32-26(21)34-16-33-24/h1-3,8,11-13,16,19H,4-6,9-10,14-15H2,(H,32,33,34)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400365
PNG
(US10695337, Example 119 | US9999619, Example 120)
Show SMILES Fc1cc(ccc1C#N)-c1ccc(cc1F)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C33H27F2N9O/c34-28-13-21(1-2-23(28)15-37)26-4-3-22(14-29(26)35)32(45)42-11-6-25(7-12-42)43-18-33(19-43,8-9-36)44-17-24(16-41-44)30-27-5-10-38-31(27)40-20-39-30/h1-5,10,13-14,16-17,20,25H,6-8,11-12,18-19H2,(H,38,39,40)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400374
PNG
(US10695337, Example 128 | US9999619, Example 129)
Show SMILES Fc1cc(cc(c1)-c1ccc(cc1F)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12)C#N
Show InChI InChI=1S/C33H27F2N9O/c34-25-12-21(15-37)11-23(13-25)27-2-1-22(14-29(27)35)32(45)42-9-4-26(5-10-42)43-18-33(19-43,6-7-36)44-17-24(16-41-44)30-28-3-8-38-31(28)40-20-39-30/h1-3,8,11-14,16-17,20,26H,4-6,9-10,18-19H2,(H,38,39,40)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400380
PNG
(US10695337, Example 134 | US9999619, Example 135)
Show SMILES Fc1cc(ccc1-c1ccc2cccnc2c1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C35H30FN9O/c36-30-16-25(5-6-28(30)24-4-3-23-2-1-12-38-31(23)17-24)34(46)43-14-8-27(9-15-43)44-20-35(21-44,10-11-37)45-19-26(18-42-45)32-29-7-13-39-33(29)41-22-40-32/h1-7,12-13,16-19,22,27H,8-10,14-15,20-21H2,(H,39,40,41)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400404
PNG
(US10695337, Example 159 | US9999619, Example 159)
Show SMILES Brc1cscc1NC(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C24H24BrN9OS/c25-19-11-36-12-20(19)31-23(35)32-7-2-17(3-8-32)33-13-24(14-33,4-5-26)34-10-16(9-30-34)21-18-1-6-27-22(18)29-15-28-21/h1,6,9-12,15,17H,2-4,7-8,13-14H2,(H,31,35)(H,27,28,29)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400405
PNG
(US10695337, Example 160 | US9999619, Example 160)
Show SMILES Clc1cccc(Cl)c1NC(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C26H25Cl2N9O/c27-20-2-1-3-21(28)23(20)34-25(38)35-10-5-18(6-11-35)36-14-26(15-36,7-8-29)37-13-17(12-33-37)22-19-4-9-30-24(19)32-16-31-22/h1-4,9,12-13,16,18H,5-7,10-11,14-15H2,(H,34,38)(H,30,31,32)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400443
PNG
(US10695337, Example 198 | US9999619, Example 198)
Show SMILES Cc1ncccc1NC(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C26H28N10O/c1-18-22(3-2-9-28-18)33-25(37)34-11-5-20(6-12-34)35-15-26(16-35,7-8-27)36-14-19(13-32-36)23-21-4-10-29-24(21)31-17-30-23/h2-4,9-10,13-14,17,20H,5-7,11-12,15-16H2,1H3,(H,33,37)(H,29,30,31)
PDB

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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400449
PNG
(US10695337, Example 204 | US9999619, Example 204)
Show SMILES COc1ncccc1NC(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C26H28N10O2/c1-38-24-21(3-2-9-29-24)33-25(37)34-11-5-19(6-12-34)35-15-26(16-35,7-8-27)36-14-18(13-32-36)22-20-4-10-28-23(20)31-17-30-22/h2-4,9-10,13-14,17,19H,5-7,11-12,15-16H2,1H3,(H,33,37)(H,28,30,31)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400453
PNG
(US10695337, Example 208 | US9999619, Example 208)
Show SMILES COC(=O)c1ccc(NC(=O)N2CCC(CC2)N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)c(F)c1
Show InChI InChI=1S/C28H28FN9O3/c1-41-26(39)18-2-3-23(22(29)12-18)35-27(40)36-10-5-20(6-11-36)37-15-28(16-37,7-8-30)38-14-19(13-34-38)24-21-4-9-31-25(21)33-17-32-24/h2-4,9,12-14,17,20H,5-7,10-11,15-16H2,1H3,(H,35,40)(H,31,32,33)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400458
PNG
(US10695337, Example 213 | US9999619, Example 213)
Show SMILES Fc1cccc(c1CN1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12)C(F)(F)F
Show InChI InChI=1S/C27H26F4N8/c28-23-3-1-2-22(27(29,30)31)21(23)14-37-10-5-19(6-11-37)38-15-26(16-38,7-8-32)39-13-18(12-36-39)24-20-4-9-33-25(20)35-17-34-24/h1-4,9,12-13,17,19H,5-7,10-11,14-16H2,(H,33,34,35)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400479
PNG
(US10695337, Example 234 | US9999619, Example 234)
Show SMILES N#CCC1(CN(C1)C1CCN(Cc2ccc3OCCOc3c2)CC1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C28H30N8O2/c29-7-6-28(36-16-21(14-33-36)26-23-3-8-30-27(23)32-19-31-26)17-35(18-28)22-4-9-34(10-5-22)15-20-1-2-24-25(13-20)38-12-11-37-24/h1-3,8,13-14,16,19,22H,4-6,9-12,15,17-18H2,(H,30,31,32)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400486
PNG
(US10695337, Example 241 | US9999619, Example 241 |...)
Show SMILES Fc1ccc(F)c(CN2C3CCC2CC(C3)N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)c1Cl
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Incyte Holdings Corporation; Incyte Corporation

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Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400497
PNG
(US10695337, Example 253 | US9999619, Example 253)
Show SMILES O=S(=O)(C1CCCC1)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C24H30N8O2S/c25-9-8-24(32-14-18(13-29-32)22-21-5-10-26-23(21)28-17-27-22)15-30(16-24)19-6-11-31(12-7-19)35(33,34)20-3-1-2-4-20/h5,10,13-14,17,19-20H,1-4,6-8,11-12,15-16H2,(H,26,27,28)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400528
PNG
(US10695337, Example 284 | US9999619, Example 284)
Show SMILES COc1ncccc1NC(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1ccc(c1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C27H29N9O2/c1-38-25-22(3-2-10-30-25)33-26(37)34-12-6-20(7-13-34)35-16-27(17-35,8-9-28)36-14-5-19(15-36)23-21-4-11-29-24(21)32-18-31-23/h2-5,10-11,14-15,18,20H,6-8,12-13,16-17H2,1H3,(H,33,37)(H,29,31,32)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM448730
PNG
(US10695337, Example 296 | {1-[1-(3-fluoro-4-hydrox...)
Show SMILES NC(=O)CC1(CN(C1)C1CCN(CC1)C(=O)c1ccc(O)c(F)c1)n1cc(cn1)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C27H28FN7O3/c28-22-11-17(1-2-23(22)36)26(38)33-9-5-19(6-10-33)34-15-27(16-34,12-24(29)37)35-14-18(13-32-35)20-3-7-30-25-21(20)4-8-31-25/h1-4,7-8,11,13-14,19,36H,5-6,9-10,12,15-16H2,(H2,29,37)(H,30,31)
PDB

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n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400560
PNG
(US10695337, Example 316 | US9999619, Example 316)
Show SMILES Fc1cc(cc(c1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1c(F)cnc2[nH]ccc12)C#N
Show InChI InChI=1S/C28H24F2N8O/c29-21-10-18(12-32)9-19(11-21)27(39)36-7-2-22(3-8-36)37-16-28(17-37,4-5-31)38-15-20(13-35-38)25-23-1-6-33-26(23)34-14-24(25)30/h1,6,9-11,13-15,22H,2-4,7-8,16-17H2,(H,33,34)
PDB

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UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400561
PNG
(US10695337, Example 317 | US9999619, Example 317)
Show SMILES Fc1cc(ccc1C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1c(F)cnc2[nH]ccc12)C#N
Show InChI InChI=1S/C28H24F2N8O/c29-23-11-18(12-32)1-2-21(23)27(39)36-9-4-20(5-10-36)37-16-28(17-37,6-7-31)38-15-19(13-35-38)25-22-3-8-33-26(22)34-14-24(25)30/h1-3,8,11,13-15,20H,4-6,9-10,16-17H2,(H,33,34)
PDB

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UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400616
PNG
(US10695337, Example 372 | US9999619, Example 372 |...)
Show SMILES FC(F)(F)c1nc(CN2CCC2)cc(n1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C29H30F3N11O/c30-29(31,32)27-38-20(15-40-8-1-9-40)12-23(39-27)26(44)41-10-3-21(4-11-41)42-16-28(17-42,5-6-33)43-14-19(13-37-43)24-22-2-7-34-25(22)36-18-35-24/h2,7,12-14,18,21H,1,3-5,8-11,15-17H2,(H,34,35,36)
PDB

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UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400620
PNG
(US10695337, Example 376 | US9999619, Example 376 |...)
Show SMILES FC(F)(F)c1nc(CN2CCCC2)cc(n1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C30H32F3N11O/c31-30(32,33)28-39-21(16-41-9-1-2-10-41)13-24(40-28)27(45)42-11-4-22(5-12-42)43-17-29(18-43,6-7-34)44-15-20(14-38-44)25-23-3-8-35-26(23)37-19-36-25/h3,8,13-15,19,22H,1-2,4-6,9-12,16-18H2,(H,35,36,37)
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UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400637
PNG
(2,4-difluorobenzyl 4-{3- (cyanomethyl)-3-[4-(7H- p...)
Show SMILES Fc1ccc(COC(=O)N2CCC(CC2)N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)c(F)c1
Show InChI InChI=1S/C27H26F2N8O2/c28-20-2-1-18(23(29)11-20)14-39-26(38)35-9-4-21(5-10-35)36-15-27(16-36,6-7-30)37-13-19(12-34-37)24-22-3-8-31-25(22)33-17-32-24/h1-3,8,11-13,17,21H,4-6,9-10,14-16H2,(H,31,32,33)
PDB

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UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400640
PNG
(US10695337, Example 396 | US9999619, Example 396 |...)
Show SMILES O=C(OCC1CCCC1)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C26H32N8O2/c27-9-8-26(34-14-20(13-31-34)23-22-5-10-28-24(22)30-18-29-23)16-33(17-26)21-6-11-32(12-7-21)25(35)36-15-19-3-1-2-4-19/h5,10,13-14,18-19,21H,1-4,6-8,11-12,15-17H2,(H,28,29,30)
PDB

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PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400269
PNG
(US10695337, Example 24 | US9999619, Example 25)
Show SMILES Clc1cc(Cl)cc(c1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C26H24Cl2N8O/c27-19-9-17(10-20(28)11-19)25(37)34-7-2-21(3-8-34)35-14-26(15-35,4-5-29)36-13-18(12-33-36)23-22-1-6-30-24(22)32-16-31-23/h1,6,9-13,16,21H,2-4,7-8,14-15H2,(H,30,31,32)
PDB

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UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400310
PNG
(US10695337, Example 64 | US9999619, Example 65)
Show SMILES Cc1ccc(cc1F)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C27H27FN8O/c1-18-2-3-19(12-23(18)28)26(37)34-10-5-21(6-11-34)35-15-27(16-35,7-8-29)36-14-20(13-33-36)24-22-4-9-30-25(22)32-17-31-24/h2-4,9,12-14,17,21H,5-7,10-11,15-16H2,1H3,(H,30,31,32)
PDB

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UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400316
PNG
(US10695337, Example 70 | US9999619, Example 71)
Show SMILES COc1cc(sc1C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12)C(F)(F)F
Show InChI InChI=1S/C26H25F3N8O2S/c1-39-19-10-20(26(27,28)29)40-22(19)24(38)35-8-3-17(4-9-35)36-13-25(14-36,5-6-30)37-12-16(11-34-37)21-18-2-7-31-23(18)33-15-32-21/h2,7,10-12,15,17H,3-5,8-9,13-14H2,1H3,(H,31,32,33)
PDB

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UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400322
PNG
(US10695337, Example 76 | US9999619, Example 77)
Show SMILES Clc1ccsc1C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C24H23ClN8OS/c25-19-4-10-35-21(19)23(34)31-8-2-17(3-9-31)32-13-24(14-32,5-6-26)33-12-16(11-30-33)20-18-1-7-27-22(18)29-15-28-20/h1,4,7,10-12,15,17H,2-3,5,8-9,13-14H2,(H,27,28,29)
PDB

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UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400333
PNG
(US10695337, Example 87 | US9999619, Example 88)
Show SMILES O=C(N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12)c1cccc2ccccc12
Show InChI InChI=1S/C30H28N8O/c31-12-11-30(38-17-22(16-35-38)27-26-8-13-32-28(26)34-20-33-27)18-37(19-30)23-9-14-36(15-10-23)29(39)25-7-3-5-21-4-1-2-6-24(21)25/h1-8,13,16-17,20,23H,9-11,14-15,18-19H2,(H,32,33,34)
PDB

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UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
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