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Patent code US10696638

Compile Data Set for Download or QSAR
Found 48 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM448523
PNG
(US10696638, formula (I) 35)
Show SMILES COc1cccc(c1)C(CN)NC(=S)Nc1ccc2cnccc2c1
Show InChI InChI=1S/C19H20N4OS/c1-24-17-4-2-3-14(10-17)18(11-20)23-19(25)22-16-6-5-15-12-21-8-7-13(15)9-16/h2-10,12,18H,11,20H2,1H3,(H2,22,23,25)
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n/an/a<10n/an/an/an/an/an/a



INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

US Patent


Assay Description
ROCK Substrate Coated Plate (Part No 241601): One strip well 96-well plate pre-coated with recombinant MYPT1.Buffer: 25 mM Tris, pH 7.5, 10 mM MgCl2,...


US Patent US10696638 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM448511
PNG
(US10696638, formula (I) 24)
Show SMILES NCC(NC(=S)Nc1ccc2cnccc2c1)c1ccccc1
Show InChI InChI=1S/C18H18N4S/c19-11-17(13-4-2-1-3-5-13)22-18(23)21-16-7-6-15-12-20-9-8-14(15)10-16/h1-10,12,17H,11,19H2,(H2,21,22,23)
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n/an/a<10n/an/an/an/an/an/a



INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

US Patent


Assay Description
ROCK Substrate Coated Plate (Part No 241601): One strip well 96-well plate pre-coated with recombinant MYPT1.Buffer: 25 mM Tris, pH 7.5, 10 mM MgCl2,...


US Patent US10696638 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM448518
PNG
(US10696638, formula (I) 31)
Show SMILES NCCN(Cc1ccc(Cl)cc1)C(=S)Nc1ccc2cnccc2c1
Show InChI InChI=1S/C19H19ClN4S/c20-17-4-1-14(2-5-17)13-24(10-8-21)19(25)23-18-6-3-16-12-22-9-7-15(16)11-18/h1-7,9,11-12H,8,10,13,21H2,(H,23,25)
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n/an/a<10n/an/an/an/an/an/a



INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

US Patent


Assay Description
ROCK Substrate Coated Plate (Part No 241601): One strip well 96-well plate pre-coated with recombinant MYPT1.Buffer: 25 mM Tris, pH 7.5, 10 mM MgCl2,...


US Patent US10696638 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM448525
PNG
(US10696638, formula (I) 37)
Show SMILES COc1ccc(CN(CCN)C(\Nc2ccc3cnccc3c2)=N/C#N)cc1
Show InChI InChI=1S/C21H22N6O/c1-28-20-6-2-16(3-7-20)14-27(11-9-22)21(25-15-23)26-19-5-4-18-13-24-10-8-17(18)12-19/h2-8,10,12-13H,9,11,14,22H2,1H3,(H,25,26)
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n/an/a<10n/an/an/an/an/an/a



INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

US Patent


Assay Description
ROCK Substrate Coated Plate (Part No 241601): One strip well 96-well plate pre-coated with recombinant MYPT1.Buffer: 25 mM Tris, pH 7.5, 10 mM MgCl2,...


US Patent US10696638 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM448524
PNG
(US10696638, formula (I) 36)
Show SMILES NCCN(Cc1ccccc1)C(\Nc1ccc2cnccc2c1)=N/C#N
Show InChI InChI=1S/C20H20N6/c21-9-11-26(14-16-4-2-1-3-5-16)20(24-15-22)25-19-7-6-18-13-23-10-8-17(18)12-19/h1-8,10,12-13H,9,11,14,21H2,(H,24,25)
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n/an/a<10n/an/an/an/an/an/a



INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

US Patent


Assay Description
ROCK Substrate Coated Plate (Part No 241601): One strip well 96-well plate pre-coated with recombinant MYPT1.Buffer: 25 mM Tris, pH 7.5, 10 mM MgCl2,...


US Patent US10696638 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM448527
PNG
(US10696638, formula (I) 39)
Show SMILES NCC(NC(=S)Nc1ccc2cnccc2c1)c1cccc2ccccc12
Show InChI InChI=1S/C22H20N4S/c23-13-21(20-7-3-5-15-4-1-2-6-19(15)20)26-22(27)25-18-9-8-17-14-24-11-10-16(17)12-18/h1-12,14,21H,13,23H2,(H2,25,26,27)
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n/an/a<10n/an/an/an/an/an/a



INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

US Patent


Assay Description
ROCK Substrate Coated Plate (Part No 241601): One strip well 96-well plate pre-coated with recombinant MYPT1.Buffer: 25 mM Tris, pH 7.5, 10 mM MgCl2,...


US Patent US10696638 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM448512
PNG
(US10696638, formula (I) 25)
Show SMILES NCC(NC(=O)Nc1ccc2cnccc2c1)c1ccc(F)cc1
Show InChI InChI=1S/C18H17FN4O/c19-15-4-1-12(2-5-15)17(10-20)23-18(24)22-16-6-3-14-11-21-8-7-13(14)9-16/h1-9,11,17H,10,20H2,(H2,22,23,24)
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n/an/a<10n/an/an/an/an/an/a



INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

US Patent


Assay Description
ROCK Substrate Coated Plate (Part No 241601): One strip well 96-well plate pre-coated with recombinant MYPT1.Buffer: 25 mM Tris, pH 7.5, 10 mM MgCl2,...


US Patent US10696638 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM448513
PNG
(US10696638, formula (I) 26)
Show SMILES NCC(NC(=S)Nc1ccc2cnccc2c1)c1ccc(F)cc1
Show InChI InChI=1S/C18H17FN4S/c19-15-4-1-12(2-5-15)17(10-20)23-18(24)22-16-6-3-14-11-21-8-7-13(14)9-16/h1-9,11,17H,10,20H2,(H2,22,23,24)
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n/an/a<10n/an/an/an/an/an/a



INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

US Patent


Assay Description
ROCK Substrate Coated Plate (Part No 241601): One strip well 96-well plate pre-coated with recombinant MYPT1.Buffer: 25 mM Tris, pH 7.5, 10 mM MgCl2,...


US Patent US10696638 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM448479
PNG
(US10696638, Table 1.2 | US10696638, formula (I) 1)
Show SMILES CN(C)CCN(Cc1ccc(F)cc1)C(=O)Nc1ccc2cnccc2c1
Show InChI InChI=1S/C21H23FN4O/c1-25(2)11-12-26(15-16-3-6-19(22)7-4-16)21(27)24-20-8-5-18-14-23-10-9-17(18)13-20/h3-10,13-14H,11-12,15H2,1-2H3,(H,24,27)
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n/an/a 55n/an/an/an/an/an/a



INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

US Patent


Assay Description
ROCK Substrate Coated Plate (Part No 241601): One strip well 96-well plate pre-coated with recombinant MYPT1.Buffer: 25 mM Tris, pH 7.5, 10 mM MgCl2,...


US Patent US10696638 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM448517
PNG
(US10696638, formula (I) 30)
Show SMILES NCCN(Cc1ccc(F)cc1)C(\Nc1ccc2cnccc2c1)=N/C#N
Show InChI InChI=1S/C20H19FN6/c21-18-4-1-15(2-5-18)13-27(10-8-22)20(25-14-23)26-19-6-3-17-12-24-9-7-16(17)11-19/h1-7,9,11-12H,8,10,13,22H2,(H,25,26)
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INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

US Patent


Assay Description
ROCK Substrate Coated Plate (Part No 241601): One strip well 96-well plate pre-coated with recombinant MYPT1.Buffer: 25 mM Tris, pH 7.5, 10 mM MgCl2,...


US Patent US10696638 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM448478
PNG
(US10696638, Table 1.1)
Show SMILES CN(C)CCN(Cc1ccc(Cl)cc1)C(=O)Nc1ccc2cnccc2c1
Show InChI InChI=1S/C21H23ClN4O/c1-25(2)11-12-26(15-16-3-6-19(22)7-4-16)21(27)24-20-8-5-18-14-23-10-9-17(18)13-20/h3-10,13-14H,11-12,15H2,1-2H3,(H,24,27)
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n/an/a 55n/an/an/an/an/an/a



INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

US Patent


Assay Description
ROCK Substrate Coated Plate (Part No 241601): One strip well 96-well plate pre-coated with recombinant MYPT1.Buffer: 25 mM Tris, pH 7.5, 10 mM MgCl2,...


US Patent US10696638 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM448483
PNG
(US10696638, Table 1.6 | US10696638, formula (I) 3)
Show SMILES OC[C@H](NC(=O)Nc1ccc2cnccc2c1)c1ccccc1
Show InChI InChI=1S/C18H17N3O2/c22-12-17(13-4-2-1-3-5-13)21-18(23)20-16-7-6-15-11-19-9-8-14(15)10-16/h1-11,17,22H,12H2,(H2,20,21,23)/t17-/m0/s1
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INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

US Patent


Assay Description
ROCK Substrate Coated Plate (Part No 241601): One strip well 96-well plate pre-coated with recombinant MYPT1.Buffer: 25 mM Tris, pH 7.5, 10 mM MgCl2,...


US Patent US10696638 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM448521
PNG
(US10696638, formula (I) 34)
Show SMILES NCCN(Cc1ccc(Br)cc1)C(\Nc1ccc2cnccc2c1)=N\C#N
Show InChI InChI=1S/C20H19BrN6/c21-18-4-1-15(2-5-18)13-27(10-8-22)20(25-14-23)26-19-6-3-17-12-24-9-7-16(17)11-19/h1-7,9,11-12H,8,10,13,22H2,(H,25,26)
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n/an/a 55n/an/an/an/an/an/a



INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

US Patent


Assay Description
ROCK Substrate Coated Plate (Part No 241601): One strip well 96-well plate pre-coated with recombinant MYPT1.Buffer: 25 mM Tris, pH 7.5, 10 mM MgCl2,...


US Patent US10696638 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM448516
PNG
(US10696638, formula (I) 29)
Show SMILES NCCN(Cc1cccc(F)c1)C(\Nc1ccc2cnccc2c1)=N/C#N
Show InChI InChI=1S/C20H19FN6/c21-18-3-1-2-15(10-18)13-27(9-7-22)20(25-14-23)26-19-5-4-17-12-24-8-6-16(17)11-19/h1-6,8,10-12H,7,9,13,22H2,(H,25,26)
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INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

US Patent


Assay Description
ROCK Substrate Coated Plate (Part No 241601): One strip well 96-well plate pre-coated with recombinant MYPT1.Buffer: 25 mM Tris, pH 7.5, 10 mM MgCl2,...


US Patent US10696638 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM448526
PNG
(US10696638, formula (I) 38)
Show SMILES NCCN(Cc1cccc(Cl)c1)C(=S)Nc1ccc2cnccc2c1
Show InChI InChI=1S/C19H19ClN4S/c20-17-3-1-2-14(10-17)13-24(9-7-21)19(25)23-18-5-4-16-12-22-8-6-15(16)11-18/h1-6,8,10-12H,7,9,13,21H2,(H,23,25)
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INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

US Patent


Assay Description
ROCK Substrate Coated Plate (Part No 241601): One strip well 96-well plate pre-coated with recombinant MYPT1.Buffer: 25 mM Tris, pH 7.5, 10 mM MgCl2,...


US Patent US10696638 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM448509
PNG
(US10696638, formula (I) 22 | US10696638, formula (...)
Show SMILES CC(N(CCN)C(=O)Nc1ccc2cnccc2c1)c1ccc(F)cc1
Show InChI InChI=1S/C20H21FN4O/c1-14(15-2-5-18(21)6-3-15)25(11-9-22)20(26)24-19-7-4-17-13-23-10-8-16(17)12-19/h2-8,10,12-14H,9,11,22H2,1H3,(H,24,26)
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n/an/a 55n/an/an/an/an/an/a



INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

US Patent


Assay Description
ROCK Substrate Coated Plate (Part No 241601): One strip well 96-well plate pre-coated with recombinant MYPT1.Buffer: 25 mM Tris, pH 7.5, 10 mM MgCl2,...


US Patent US10696638 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM448505
PNG
(US10696638, formula (I) 19)
Show SMILES NCCN(Cc1ccc(F)cc1)C(=S)Nc1ccc2cnccc2c1
Show InChI InChI=1S/C19H19FN4S/c20-17-4-1-14(2-5-17)13-24(10-8-21)19(25)23-18-6-3-16-12-22-9-7-15(16)11-18/h1-7,9,11-12H,8,10,13,21H2,(H,23,25)
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n/an/a 550n/an/an/an/an/an/a



INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

US Patent


Assay Description
ROCK Substrate Coated Plate (Part No 241601): One strip well 96-well plate pre-coated with recombinant MYPT1.Buffer: 25 mM Tris, pH 7.5, 10 mM MgCl2,...


US Patent US10696638 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM448509
PNG
(US10696638, formula (I) 22 | US10696638, formula (...)
Show SMILES CC(N(CCN)C(=O)Nc1ccc2cnccc2c1)c1ccc(F)cc1
Show InChI InChI=1S/C20H21FN4O/c1-14(15-2-5-18(21)6-3-15)25(11-9-22)20(26)24-19-7-4-17-13-23-10-8-16(17)12-19/h2-8,10,12-14H,9,11,22H2,1H3,(H,24,26)
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n/an/a 550n/an/an/an/an/an/a



INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

US Patent


Assay Description
ROCK Substrate Coated Plate (Part No 241601): One strip well 96-well plate pre-coated with recombinant MYPT1.Buffer: 25 mM Tris, pH 7.5, 10 mM MgCl2,...


US Patent US10696638 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM448497
PNG
(US10696638, formula (I) 11)
Show SMILES CN(C)CCN(Cc1ccc(F)cc1)C(=S)Nc1cccc2cnccc12
Show InChI InChI=1S/C21H23FN4S/c1-25(2)12-13-26(15-16-6-8-18(22)9-7-16)21(27)24-20-5-3-4-17-14-23-11-10-19(17)20/h3-11,14H,12-13,15H2,1-2H3,(H,24,27)
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n/an/a 550n/an/an/an/an/an/a



INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

US Patent


Assay Description
ROCK Substrate Coated Plate (Part No 241601): One strip well 96-well plate pre-coated with recombinant MYPT1.Buffer: 25 mM Tris, pH 7.5, 10 mM MgCl2,...


US Patent US10696638 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM448494
PNG
(US10696638, formula (I) 8)
Show SMILES NCCN(Cc1ccc(F)cc1)C(=O)Nc1ccc2cnccc2c1
Show InChI InChI=1S/C19H19FN4O/c20-17-4-1-14(2-5-17)13-24(10-8-21)19(25)23-18-6-3-16-12-22-9-7-15(16)11-18/h1-7,9,11-12H,8,10,13,21H2,(H,23,25)
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n/an/a 550n/an/an/an/an/an/a



INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

US Patent


Assay Description
ROCK Substrate Coated Plate (Part No 241601): One strip well 96-well plate pre-coated with recombinant MYPT1.Buffer: 25 mM Tris, pH 7.5, 10 mM MgCl2,...


US Patent US10696638 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM448485
PNG
(US10696638, Table 1.8)
Show SMILES CN(C)CCN(Cc1cccc(F)c1)C(=O)Nc1ccc2cnccc2c1
Show InChI InChI=1S/C21H23FN4O/c1-25(2)10-11-26(15-16-4-3-5-19(22)12-16)21(27)24-20-7-6-18-14-23-9-8-17(18)13-20/h3-9,12-14H,10-11,15H2,1-2H3,(H,24,27)
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n/an/a 550n/an/an/an/an/an/a



INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

US Patent


Assay Description
ROCK Substrate Coated Plate (Part No 241601): One strip well 96-well plate pre-coated with recombinant MYPT1.Buffer: 25 mM Tris, pH 7.5, 10 mM MgCl2,...


US Patent US10696638 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM448481
PNG
(US10696638, Table 1.4 | US10696638, formula (I) 2)
Show SMILES COc1cccc(CN(CCO)C(=O)Nc2ccc3cnccc3c2)c1
Show InChI InChI=1S/C20H21N3O3/c1-26-19-4-2-3-15(11-19)14-23(9-10-24)20(25)22-18-6-5-17-13-21-8-7-16(17)12-18/h2-8,11-13,24H,9-10,14H2,1H3,(H,22,25)
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n/an/a 550n/an/an/an/an/an/a



INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

US Patent


Assay Description
ROCK Substrate Coated Plate (Part No 241601): One strip well 96-well plate pre-coated with recombinant MYPT1.Buffer: 25 mM Tris, pH 7.5, 10 mM MgCl2,...


US Patent US10696638 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM448515
PNG
(US10696638, formula (I) 28)
Show SMILES NCCN(Cc1cccc(F)c1)C(=S)Nc1ccc2cnccc2c1
Show InChI InChI=1S/C19H19FN4S/c20-17-3-1-2-14(10-17)13-24(9-7-21)19(25)23-18-5-4-16-12-22-8-6-15(16)11-18/h1-6,8,10-12H,7,9,13,21H2,(H,23,25)
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n/an/a 550n/an/an/an/an/an/a



INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

US Patent


Assay Description
ROCK Substrate Coated Plate (Part No 241601): One strip well 96-well plate pre-coated with recombinant MYPT1.Buffer: 25 mM Tris, pH 7.5, 10 mM MgCl2,...


US Patent US10696638 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM448502
PNG
(US10696638, formula (I) 16)
Show SMILES NCCN(Cc1cccc(F)c1)C(=O)Nc1ccc2cnccc2c1
Show InChI InChI=1S/C19H19FN4O/c20-17-3-1-2-14(10-17)13-24(9-7-21)19(25)23-18-5-4-16-12-22-8-6-15(16)11-18/h1-6,8,10-12H,7,9,13,21H2,(H,23,25)
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n/an/a 550n/an/an/an/an/an/a



INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

US Patent


Assay Description
ROCK Substrate Coated Plate (Part No 241601): One strip well 96-well plate pre-coated with recombinant MYPT1.Buffer: 25 mM Tris, pH 7.5, 10 mM MgCl2,...


US Patent US10696638 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM448501
PNG
(US10696638, formula (I) 15)
Show SMILES NCCN(Cc1ccc(Br)cc1)C(=O)Nc1ccc2cnccc2c1
Show InChI InChI=1S/C19H19BrN4O/c20-17-4-1-14(2-5-17)13-24(10-8-21)19(25)23-18-6-3-16-12-22-9-7-15(16)11-18/h1-7,9,11-12H,8,10,13,21H2,(H,23,25)
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n/an/a 550n/an/an/an/an/an/a



INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

US Patent


Assay Description
ROCK Substrate Coated Plate (Part No 241601): One strip well 96-well plate pre-coated with recombinant MYPT1.Buffer: 25 mM Tris, pH 7.5, 10 mM MgCl2,...


US Patent US10696638 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM448519
PNG
(US10696638, formula (I) 32)
Show SMILES Cc1ccc(CN(CCN)C(=S)Nc2ccc3cnccc3c2)cc1
Show InChI InChI=1S/C20H22N4S/c1-15-2-4-16(5-3-15)14-24(11-9-21)20(25)23-19-7-6-18-13-22-10-8-17(18)12-19/h2-8,10,12-13H,9,11,14,21H2,1H3,(H,23,25)
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n/an/a 550n/an/an/an/an/an/a



INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

US Patent


Assay Description
ROCK Substrate Coated Plate (Part No 241601): One strip well 96-well plate pre-coated with recombinant MYPT1.Buffer: 25 mM Tris, pH 7.5, 10 mM MgCl2,...


US Patent US10696638 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM448520
PNG
(US10696638, formula (I) 33)
Show SMILES NCCN(Cc1ccc(Cl)c(F)c1)C(=S)Nc1ccc2cnccc2c1
Show InChI InChI=1S/C19H18ClFN4S/c20-17-4-1-13(9-18(17)21)12-25(8-6-22)19(26)24-16-3-2-15-11-23-7-5-14(15)10-16/h1-5,7,9-11H,6,8,12,22H2,(H,24,26)
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n/an/a 550n/an/an/an/an/an/a



INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

US Patent


Assay Description
ROCK Substrate Coated Plate (Part No 241601): One strip well 96-well plate pre-coated with recombinant MYPT1.Buffer: 25 mM Tris, pH 7.5, 10 mM MgCl2,...


US Patent US10696638 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM448500
PNG
(US10696638, formula (I) 14)
Show SMILES NCCN(Cc1ccccc1)C(=O)Nc1ccc2cnccc2c1
Show InChI InChI=1S/C19H20N4O/c20-9-11-23(14-15-4-2-1-3-5-15)19(24)22-18-7-6-17-13-21-10-8-16(17)12-18/h1-8,10,12-13H,9,11,14,20H2,(H,22,24)
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n/an/a 550n/an/an/an/an/an/a



INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

US Patent


Assay Description
ROCK Substrate Coated Plate (Part No 241601): One strip well 96-well plate pre-coated with recombinant MYPT1.Buffer: 25 mM Tris, pH 7.5, 10 mM MgCl2,...


US Patent US10696638 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM448493
PNG
(US10696638, formula (I) 7)
Show SMILES CN(C)CCN(Cc1ccc(Cl)cc1)C(=O)Nc1cccc2cnccc12
Show InChI InChI=1S/C21H23ClN4O/c1-25(2)12-13-26(15-16-6-8-18(22)9-7-16)21(27)24-20-5-3-4-17-14-23-11-10-19(17)20/h3-11,14H,12-13,15H2,1-2H3,(H,24,27)
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n/an/a 550n/an/an/an/an/an/a



INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

US Patent


Assay Description
ROCK Substrate Coated Plate (Part No 241601): One strip well 96-well plate pre-coated with recombinant MYPT1.Buffer: 25 mM Tris, pH 7.5, 10 mM MgCl2,...


US Patent US10696638 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM448492
PNG
(US10696638, formula (I) 6)
Show SMILES CN(C)CCN(Cc1ccccc1)C(=O)Nc1cccc2cnccc12
Show InChI InChI=1S/C21H24N4O/c1-24(2)13-14-25(16-17-7-4-3-5-8-17)21(26)23-20-10-6-9-18-15-22-12-11-19(18)20/h3-12,15H,13-14,16H2,1-2H3,(H,23,26)
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n/an/a 550n/an/an/an/an/an/a



INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

US Patent


Assay Description
ROCK Substrate Coated Plate (Part No 241601): One strip well 96-well plate pre-coated with recombinant MYPT1.Buffer: 25 mM Tris, pH 7.5, 10 mM MgCl2,...


US Patent US10696638 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM448480
PNG
(US10696638, Table 1.3)
Show SMILES COc1cccc(CN(CCN(C)C)C(=O)Nc2ccc3cnccc3c2)c1
Show InChI InChI=1S/C22H26N4O2/c1-25(2)11-12-26(16-17-5-4-6-21(13-17)28-3)22(27)24-20-8-7-19-15-23-10-9-18(19)14-20/h4-10,13-15H,11-12,16H2,1-3H3,(H,24,27)
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n/an/a 550n/an/an/an/an/an/a



INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

US Patent


Assay Description
ROCK Substrate Coated Plate (Part No 241601): One strip well 96-well plate pre-coated with recombinant MYPT1.Buffer: 25 mM Tris, pH 7.5, 10 mM MgCl2,...


US Patent US10696638 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM448514
PNG
(US10696638, formula (I) 27)
Show SMILES NCCN(Cc1ccccc1)C(=S)Nc1ccc2cnccc2c1
Show InChI InChI=1S/C19H20N4S/c20-9-11-23(14-15-4-2-1-3-5-15)19(24)22-18-7-6-17-13-21-10-8-16(17)12-18/h1-8,10,12-13H,9,11,14,20H2,(H,22,24)
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n/an/a 550n/an/an/an/an/an/a



INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

US Patent


Assay Description
ROCK Substrate Coated Plate (Part No 241601): One strip well 96-well plate pre-coated with recombinant MYPT1.Buffer: 25 mM Tris, pH 7.5, 10 mM MgCl2,...


US Patent US10696638 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM448507
PNG
(US10696638, formula (I) 20 | US10696638, formula (...)
Show SMILES NCCN(Cc1ccc(F)cc1)C(=O)Nc1cccc2cnccc12
Show InChI InChI=1S/C19H19FN4O/c20-16-6-4-14(5-7-16)13-24(11-9-21)19(25)23-18-3-1-2-15-12-22-10-8-17(15)18/h1-8,10,12H,9,11,13,21H2,(H,23,25)
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n/an/a>1.00E+3n/an/an/an/an/an/a



INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

US Patent


Assay Description
ROCK Substrate Coated Plate (Part No 241601): One strip well 96-well plate pre-coated with recombinant MYPT1.Buffer: 25 mM Tris, pH 7.5, 10 mM MgCl2,...


US Patent US10696638 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM448507
PNG
(US10696638, formula (I) 20 | US10696638, formula (...)
Show SMILES NCCN(Cc1ccc(F)cc1)C(=O)Nc1cccc2cnccc12
Show InChI InChI=1S/C19H19FN4O/c20-16-6-4-14(5-7-16)13-24(11-9-21)19(25)23-18-3-1-2-15-12-22-10-8-17(15)18/h1-8,10,12H,9,11,13,21H2,(H,23,25)
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INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

US Patent


Assay Description
ROCK Substrate Coated Plate (Part No 241601): One strip well 96-well plate pre-coated with recombinant MYPT1.Buffer: 25 mM Tris, pH 7.5, 10 mM MgCl2,...


US Patent US10696638 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM448490
PNG
(US10696638, formula (I) 4)
Show SMILES OC[C@H](NC(=O)Nc1cccc2cnccc12)c1ccccc1
Show InChI InChI=1S/C18H17N3O2/c22-12-17(13-5-2-1-3-6-13)21-18(23)20-16-8-4-7-14-11-19-10-9-15(14)16/h1-11,17,22H,12H2,(H2,20,21,23)/t17-/m0/s1
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INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

US Patent


Assay Description
ROCK Substrate Coated Plate (Part No 241601): One strip well 96-well plate pre-coated with recombinant MYPT1.Buffer: 25 mM Tris, pH 7.5, 10 mM MgCl2,...


US Patent US10696638 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM448498
PNG
(US10696638, formula (I) 12)
Show SMILES CN(C)CCN(Cc1ccc(CO)cc1)C(=S)Nc1cccc2cnccc12
Show InChI InChI=1S/C22H26N4OS/c1-25(2)12-13-26(15-17-6-8-18(16-27)9-7-17)22(28)24-21-5-3-4-19-14-23-11-10-20(19)21/h3-11,14,27H,12-13,15-16H2,1-2H3,(H,24,28)
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INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

US Patent


Assay Description
ROCK Substrate Coated Plate (Part No 241601): One strip well 96-well plate pre-coated with recombinant MYPT1.Buffer: 25 mM Tris, pH 7.5, 10 mM MgCl2,...


US Patent US10696638 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM448503
PNG
(US10696638, formula (I) 17)
Show SMILES CSc1ccc(CN(CCN)C(=O)Nc2ccc3cnccc3c2)cc1
Show InChI InChI=1S/C20H22N4OS/c1-26-19-6-2-15(3-7-19)14-24(11-9-21)20(25)23-18-5-4-17-13-22-10-8-16(17)12-18/h2-8,10,12-13H,9,11,14,21H2,1H3,(H,23,25)
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INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

US Patent


Assay Description
ROCK Substrate Coated Plate (Part No 241601): One strip well 96-well plate pre-coated with recombinant MYPT1.Buffer: 25 mM Tris, pH 7.5, 10 mM MgCl2,...


US Patent US10696638 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM448495
PNG
(US10696638, formula (I) 9)
Show SMILES Clc1ccc(CN(C2CCNCC2)C(=O)Nc2cccc3cnccc23)cc1
Show InChI InChI=1S/C22H23ClN4O/c23-18-6-4-16(5-7-18)15-27(19-8-11-24-12-9-19)22(28)26-21-3-1-2-17-14-25-13-10-20(17)21/h1-7,10,13-14,19,24H,8-9,11-12,15H2,(H,26,28)
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INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

US Patent


Assay Description
ROCK Substrate Coated Plate (Part No 241601): One strip well 96-well plate pre-coated with recombinant MYPT1.Buffer: 25 mM Tris, pH 7.5, 10 mM MgCl2,...


US Patent US10696638 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM448481
PNG
(US10696638, Table 1.4 | US10696638, formula (I) 2)
Show SMILES COc1cccc(CN(CCO)C(=O)Nc2ccc3cnccc3c2)c1
Show InChI InChI=1S/C20H21N3O3/c1-26-19-4-2-3-15(11-19)14-23(9-10-24)20(25)22-18-6-5-17-13-21-8-7-16(17)12-18/h2-8,11-13,24H,9-10,14H2,1H3,(H,22,25)
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INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

US Patent


Assay Description
ROCK Substrate Coated Plate (Part No 241601): One strip well 96-well plate pre-coated with recombinant MYPT1.Buffer: 25 mM Tris, pH 7.5, 10 mM MgCl2,...


US Patent US10696638 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM448504
PNG
(US10696638, formula (I) 18)
Show SMILES COC(=O)c1ccc(CN(CCN)C(=O)Nc2ccc3cnccc3c2)cc1
Show InChI InChI=1S/C21H22N4O3/c1-28-20(26)16-4-2-15(3-5-16)14-25(11-9-22)21(27)24-19-7-6-18-13-23-10-8-17(18)12-19/h2-8,10,12-13H,9,11,14,22H2,1H3,(H,24,27)
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INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

US Patent


Assay Description
ROCK Substrate Coated Plate (Part No 241601): One strip well 96-well plate pre-coated with recombinant MYPT1.Buffer: 25 mM Tris, pH 7.5, 10 mM MgCl2,...


US Patent US10696638 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM448491
PNG
(US10696638, formula (I) 5)
Show SMILES CN(C)CCN(Cc1ccc(F)cc1)C(=O)Nc1cccc2cnccc12
Show InChI InChI=1S/C21H23FN4O/c1-25(2)12-13-26(15-16-6-8-18(22)9-7-16)21(27)24-20-5-3-4-17-14-23-11-10-19(17)20/h3-11,14H,12-13,15H2,1-2H3,(H,24,27)
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INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

US Patent


Assay Description
ROCK Substrate Coated Plate (Part No 241601): One strip well 96-well plate pre-coated with recombinant MYPT1.Buffer: 25 mM Tris, pH 7.5, 10 mM MgCl2,...


US Patent US10696638 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM448483
PNG
(US10696638, Table 1.6 | US10696638, formula (I) 3)
Show SMILES OC[C@H](NC(=O)Nc1ccc2cnccc2c1)c1ccccc1
Show InChI InChI=1S/C18H17N3O2/c22-12-17(13-4-2-1-3-5-13)21-18(23)20-16-7-6-15-11-19-9-8-14(15)10-16/h1-11,17,22H,12H2,(H2,20,21,23)/t17-/m0/s1
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INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

US Patent


Assay Description
ROCK Substrate Coated Plate (Part No 241601): One strip well 96-well plate pre-coated with recombinant MYPT1.Buffer: 25 mM Tris, pH 7.5, 10 mM MgCl2,...


US Patent US10696638 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM448499
PNG
(US10696638, formula (I) 13)
Show SMILES NCCN(Cc1ccc(O)cc1)C(=O)Nc1ccc2cnccc2c1
Show InChI InChI=1S/C19H20N4O2/c20-8-10-23(13-14-1-5-18(24)6-2-14)19(25)22-17-4-3-16-12-21-9-7-15(16)11-17/h1-7,9,11-12,24H,8,10,13,20H2,(H,22,25)
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n/an/a>1.00E+3n/an/an/an/an/an/a



INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

US Patent


Assay Description
ROCK Substrate Coated Plate (Part No 241601): One strip well 96-well plate pre-coated with recombinant MYPT1.Buffer: 25 mM Tris, pH 7.5, 10 mM MgCl2,...


US Patent US10696638 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM448484
PNG
(US10696638, Table 1.7)
Show SMILES CN(C)CCN(Cc1ccccc1)C(=O)Nc1ccc2cnccc2c1
Show InChI InChI=1S/C21H24N4O/c1-24(2)12-13-25(16-17-6-4-3-5-7-17)21(26)23-20-9-8-19-15-22-11-10-18(19)14-20/h3-11,14-15H,12-13,16H2,1-2H3,(H,23,26)
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INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

US Patent


Assay Description
ROCK Substrate Coated Plate (Part No 241601): One strip well 96-well plate pre-coated with recombinant MYPT1.Buffer: 25 mM Tris, pH 7.5, 10 mM MgCl2,...


US Patent US10696638 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM448486
PNG
(US10696638, Table 1.9)
Show SMILES CN(C)CCN(Cc1ccc(Oc2ccc(cc2)C#N)cc1)C(=O)Nc1ccc2cnccc2c1
Show InChI InChI=1S/C28H27N5O2/c1-32(2)15-16-33(28(34)31-25-8-7-24-19-30-14-13-23(24)17-25)20-22-5-11-27(12-6-22)35-26-9-3-21(18-29)4-10-26/h3-14,17,19H,15-16,20H2,1-2H3,(H,31,34)
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n/an/a>1.00E+3n/an/an/an/an/an/a



INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

US Patent


Assay Description
ROCK Substrate Coated Plate (Part No 241601): One strip well 96-well plate pre-coated with recombinant MYPT1.Buffer: 25 mM Tris, pH 7.5, 10 mM MgCl2,...


US Patent US10696638 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM448482
PNG
(US10696638, Table 1.5)
Show SMILES COC(=O)c1ccc(CN(CCO)C(=O)Nc2ccc3cnccc3c2)cc1
Show InChI InChI=1S/C21H21N3O4/c1-28-20(26)16-4-2-15(3-5-16)14-24(10-11-25)21(27)23-19-7-6-18-13-22-9-8-17(18)12-19/h2-9,12-13,25H,10-11,14H2,1H3,(H,23,27)
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n/an/a>1.00E+3n/an/an/an/an/an/a



INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

US Patent


Assay Description
ROCK Substrate Coated Plate (Part No 241601): One strip well 96-well plate pre-coated with recombinant MYPT1.Buffer: 25 mM Tris, pH 7.5, 10 mM MgCl2,...


US Patent US10696638 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM448479
PNG
(US10696638, Table 1.2 | US10696638, formula (I) 1)
Show SMILES CN(C)CCN(Cc1ccc(F)cc1)C(=O)Nc1ccc2cnccc2c1
Show InChI InChI=1S/C21H23FN4O/c1-25(2)11-12-26(15-16-3-6-19(22)7-4-16)21(27)24-20-8-5-18-14-23-10-9-17(18)13-20/h3-10,13-14H,11-12,15H2,1-2H3,(H,24,27)
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n/an/a>1.00E+3n/an/an/an/an/an/a



INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

US Patent


Assay Description
ROCK Substrate Coated Plate (Part No 241601): One strip well 96-well plate pre-coated with recombinant MYPT1.Buffer: 25 mM Tris, pH 7.5, 10 mM MgCl2,...


US Patent US10696638 (2020)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM448496
PNG
(US10696638, formula (I) 10)
Show SMILES COC(=O)c1ccc(CN(CCN(C)C)C(=O)Nc2cccc3cnccc23)cc1
Show InChI InChI=1S/C23H26N4O3/c1-26(2)13-14-27(16-17-7-9-18(10-8-17)22(28)30-3)23(29)25-21-6-4-5-19-15-24-12-11-20(19)21/h4-12,15H,13-14,16H2,1-3H3,(H,25,29)
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n/an/a>1.00E+3n/an/an/an/an/an/a



INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

US Patent


Assay Description
ROCK Substrate Coated Plate (Part No 241601): One strip well 96-well plate pre-coated with recombinant MYPT1.Buffer: 25 mM Tris, pH 7.5, 10 mM MgCl2,...


US Patent US10696638 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%