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Patent code US10696655

Compile Data Set for Download or QSAR
Found 125 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
CREB-binding protein


(Homo sapiens (Human))
BDBM448659
PNG
(3-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)...)
Show SMILES CNC(=O)c1ccc2n(nc(N3CCCc4cc(-c5cnn(C)c5)c(cc34)C(F)F)c2n1)C1CCOCC1
Show InChI InChI=1S/C27H29F2N7O2/c1-30-27(37)21-5-6-22-24(32-21)26(33-36(22)18-7-10-38-11-8-18)35-9-3-4-16-12-19(17-14-31-34(2)15-17)20(25(28)29)13-23(16)35/h5-6,12-15,18,25H,3-4,7-11H2,1-2H3,(H,30,37)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448593
PNG
(5-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)...)
Show SMILES CNC(=O)c1c[nH]c2c(C)nc(cc12)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C24H24F2N6O/c1-13-22-17(19(11-28-22)24(33)27-2)9-21(30-13)32-6-4-5-14-7-16(15-10-29-31(3)12-15)18(23(25)26)8-20(14)32/h7-12,23,28H,4-6H2,1-3H3,(H,27,33)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50250892
PNG
(CHEMBL4061254 | US10696655, Example 63)
Show SMILES CNC(=O)c1c[nH]c2c(nc(cc12)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F)C(C)C
Show InChI InChI=1S/C26H28F2N6O/c1-14(2)23-24-18(20(12-30-24)26(35)29-3)10-22(32-23)34-7-5-6-15-8-17(16-11-31-33(4)13-16)19(25(27)28)9-21(15)34/h8-14,25,30H,5-7H2,1-4H3,(H,29,35)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448598
PNG
(US10696655, Example 69)
Show SMILES CNC(=O)c1c[nH]c2ncc(nc12)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C22H21F2N7O/c1-25-22(32)16-9-26-21-19(16)29-18(10-27-21)31-5-3-4-12-6-14(13-8-28-30(2)11-13)15(20(23)24)7-17(12)31/h6-11,20H,3-5H2,1-2H3,(H,25,32)(H,26,27)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50250911
PNG
(CHEMBL4095153 | US10696655, Example 45)
Show SMILES Cn1cc(cn1)-c1cc2CCCN(c3cc(N4CCOCC4)c4n(C)c(=O)n(C)c4c3)c2cc1C(F)F
Show InChI InChI=1S/C27H30F2N6O2/c1-31-16-18(15-30-31)20-11-17-5-4-6-35(22(17)14-21(20)26(28)29)19-12-23-25(33(3)27(36)32(23)2)24(13-19)34-7-9-37-10-8-34/h11-16,26H,4-10H2,1-3H3
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448595
PNG
(US10696655, Example 66)
Show SMILES CNC(=O)c1c[nH]c2c(C)cc(nc12)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C24H24F2N6O/c1-13-7-20(30-22-18(24(33)27-2)11-28-21(13)22)32-6-4-5-14-8-16(15-10-29-31(3)12-15)17(23(25)26)9-19(14)32/h7-12,23,28H,4-6H2,1-3H3,(H,27,33)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448632
PNG
(6-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)...)
Show SMILES Cn1cc(cn1)-c1cc2CCCN(c3cc(C4=CCS(=O)CC4)c4n(C)c(=O)n(C)c4c3)c2cc1C(F)F
Show InChI InChI=1S/C28H29F2N5O2S/c1-32-16-19(15-31-32)21-11-18-5-4-8-35(24(18)14-23(21)27(29)30)20-12-22(17-6-9-38(37)10-7-17)26-25(13-20)33(2)28(36)34(26)3/h6,11-16,27H,4-5,7-10H2,1-3H3
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448631
PNG
(6-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)...)
Show SMILES Cn1cc(cn1)-c1cc2CCCN(c3cc(C4CCOCC4)c4n(C)c(=O)n(C)c4c3)c2cc1C(F)F
Show InChI InChI=1S/C28H31F2N5O2/c1-32-16-19(15-31-32)21-11-18-5-4-8-35(24(18)14-23(21)27(29)30)20-12-22(17-6-9-37-10-7-17)26-25(13-20)33(2)28(36)34(26)3/h11-17,27H,4-10H2,1-3H3
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448584
PNG
(US10696655, Example 55)
Show SMILES CNC(=O)c1cn(C)c2ccc(N3CCCc4cc(-c5cnn(C)c5)c(cc34)C(F)F)c(F)c12
Show InChI InChI=1S/C25H24F3N5O/c1-29-25(34)18-13-31(2)19-6-7-20(23(26)22(18)19)33-8-4-5-14-9-16(15-11-30-32(3)12-15)17(24(27)28)10-21(14)33/h6-7,9-13,24H,4-5,8H2,1-3H3,(H,29,34)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448594
PNG
(US10696655, Example 65)
Show SMILES CNC(=O)c1c[nH]c2ccc(nc12)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C23H22F2N6O/c1-26-23(32)17-11-27-18-5-6-20(29-21(17)18)31-7-3-4-13-8-15(14-10-28-30(2)12-14)16(22(24)25)9-19(13)31/h5-6,8-12,22,27H,3-4,7H2,1-2H3,(H,26,32)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448569
PNG
(6-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)...)
Show SMILES CN(C)c1cc(cc2n(C)c(=O)n(C)c12)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C25H28F2N6O/c1-29(2)21-10-17(11-22-23(21)32(5)25(34)31(22)4)33-8-6-7-15-9-18(16-13-28-30(3)14-16)19(24(26)27)12-20(15)33/h9-14,24H,6-8H2,1-5H3
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50250913
PNG
(CHEMBL4073812 | US10696655, Example 67)
Show SMILES CNC(=O)c1c[nH]c2cnc(cc12)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C23H22F2N6O/c1-26-23(32)18-10-27-19-11-28-21(8-16(18)19)31-5-3-4-13-6-15(14-9-29-30(2)12-14)17(22(24)25)7-20(13)31/h6-12,22,27H,3-5H2,1-2H3,(H,26,32)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448572
PNG
(US10696655, Example 43)
Show SMILES Cn1cc(cn1)-c1cc2CCCN(c3cc(N4CCCC4)c4n(C)c(=O)n(C)c4c3)c2cc1C(F)F
Show InChI InChI=1S/C27H30F2N6O/c1-31-16-18(15-30-31)20-11-17-7-6-10-35(22(17)14-21(20)26(28)29)19-12-23-25(33(3)27(36)32(23)2)24(13-19)34-8-4-5-9-34/h11-16,26H,4-10H2,1-3H3
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448588
PNG
(US10696655, Example 59)
Show SMILES CNC(=O)c1cn(C)c2cnc(cc12)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C24H24F2N6O/c1-27-24(33)19-13-30(2)21-11-28-22(9-17(19)21)32-6-4-5-14-7-16(15-10-29-31(3)12-15)18(23(25)26)8-20(14)32/h7-13,23H,4-6H2,1-3H3,(H,27,33)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448654
PNG
(7-(difluoromethyl)-N-methyl-6-(1-methyl-1H-pyrazol...)
Show SMILES CNC(=O)c1ccc2cccc(N3CCCc4cc(-c5cnn(C)c5)c(cc34)C(F)F)c2n1
Show InChI InChI=1S/C25H23F2N5O/c1-28-25(33)20-9-8-15-5-3-7-21(23(15)30-20)32-10-4-6-16-11-18(17-13-29-31(2)14-17)19(24(26)27)12-22(16)32/h3,5,7-9,11-14,24H,4,6,10H2,1-2H3,(H,28,33)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448543
PNG
(7-[7-(difluoromethyl)-6-(1-methylpyrazol-4-yl)-3,4...)
Show SMILES CNC(=O)N1CCNc2ccc(cc2C1)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C25H28F2N6O/c1-28-25(34)32-9-7-29-22-6-5-19(10-17(22)15-32)33-8-3-4-16-11-20(18-13-30-31(2)14-18)21(24(26)27)12-23(16)33/h5-6,10-14,24,29H,3-4,7-9,15H2,1-2H3,(H,28,34)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50250896
PNG
(CHEMBL4065346 | US10696655, Example 52)
Show SMILES CNC(=O)c1c[nH]c2ccc(cc12)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C24H23F2N5O/c1-27-24(32)20-12-28-21-6-5-16(9-18(20)21)31-7-3-4-14-8-17(15-11-29-30(2)13-15)19(23(25)26)10-22(14)31/h5-6,8-13,23,28H,3-4,7H2,1-2H3,(H,27,32)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
CREB-binding protein


(Homo sapiens (Human))
BDBM448616
PNG
(3-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)...)
Show SMILES CNC(=O)c1ccc2n(nc(N3CCCc4cc(-c5cnn(C)c5)c(cc34)C(F)F)c2c1)C1CCOCC1
Show InChI InChI=1S/C28H30F2N6O2/c1-31-28(37)18-5-6-24-23(13-18)27(33-36(24)20-7-10-38-11-8-20)35-9-3-4-17-12-21(19-15-32-34(2)16-19)22(26(29)30)14-25(17)35/h5-6,12-16,20,26H,3-4,7-11H2,1-2H3,(H,31,37)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448589
PNG
(US10696655, Example 60)
Show SMILES CNC(=O)c1cn(C)c2c(C)cc(nc12)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C25H26F2N6O/c1-14-8-21(30-22-19(25(34)28-2)13-31(3)23(14)22)33-7-5-6-15-9-17(16-11-29-32(4)12-16)18(24(26)27)10-20(15)33/h8-13,24H,5-7H2,1-4H3,(H,28,34)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448630
PNG
(6-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)...)
Show SMILES CC(C)c1cc(cc2n(C)c(=O)n(C)c12)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C26H29F2N5O/c1-15(2)19-10-18(11-23-24(19)32(5)26(34)31(23)4)33-8-6-7-16-9-20(17-13-29-30(3)14-17)21(25(27)28)12-22(16)33/h9-15,25H,6-8H2,1-5H3
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n/an/a 9n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448586
PNG
(US10696655, Example 57)
Show SMILES CNC(=O)c1cn(C)c2cc(C)c(cc12)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C26H27F2N5O/c1-15-8-24-19(21(14-31(24)3)26(34)29-2)10-22(15)33-7-5-6-16-9-18(17-12-30-32(4)13-17)20(25(27)28)11-23(16)33/h8-14,25H,5-7H2,1-4H3,(H,29,34)
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n/an/a 9n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448578
PNG
(5-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)...)
Show SMILES CNC(=O)c1cn(C)c2ccc(cc12)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C25H25F2N5O/c1-28-25(33)21-14-30(2)22-7-6-17(10-19(21)22)32-8-4-5-15-9-18(16-12-29-31(3)13-16)20(24(26)27)11-23(15)32/h6-7,9-14,24H,4-5,8H2,1-3H3,(H,28,33)
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n/an/a 9n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448587
PNG
(US10696655, Example 58)
Show SMILES CNC(=O)c1cn(C)c2ccc(nc12)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C24H24F2N6O/c1-27-24(33)18-13-30(2)19-6-7-21(29-22(18)19)32-8-4-5-14-9-16(15-11-28-31(3)12-15)17(23(25)26)10-20(14)32/h6-7,9-13,23H,4-5,8H2,1-3H3,(H,27,33)
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n/an/a 9n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448634
PNG
(6-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)...)
Show SMILES COc1cc(cc2n(C)c(=O)n(C)c12)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C24H25F2N5O2/c1-28-13-15(12-27-28)17-8-14-6-5-7-31(19(14)11-18(17)23(25)26)16-9-20-22(21(10-16)33-4)30(3)24(32)29(20)2/h8-13,23H,5-7H2,1-4H3
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n/an/a 10n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448585
PNG
(US10696655, Example 56)
Show SMILES CNC(=O)c1cn(C)c2cc(F)c(cc12)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C25H24F3N5O/c1-29-25(34)19-13-31(2)22-10-20(26)23(8-17(19)22)33-6-4-5-14-7-16(15-11-30-32(3)12-15)18(24(27)28)9-21(14)33/h7-13,24H,4-6H2,1-3H3,(H,29,34)
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n/an/a 10n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448565
PNG
(US10696655, Example 37)
Show SMILES CCc1cc(cc2n(C)c(=O)n(C)c12)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C25H27F2N5O/c1-5-15-9-18(11-22-23(15)31(4)25(33)30(22)3)32-8-6-7-16-10-19(17-13-28-29(2)14-17)20(24(26)27)12-21(16)32/h9-14,24H,5-8H2,1-4H3
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n/an/a 11n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448639
PNG
(5-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)...)
Show SMILES CNC(=O)c1cn(C)c2c(cc(cc12)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F)C1CCOCC1
Show InChI InChI=1S/C30H33F2N5O2/c1-33-30(38)26-17-35(2)28-23(18-6-9-39-10-7-18)12-21(13-24(26)28)37-8-4-5-19-11-22(20-15-34-36(3)16-20)25(29(31)32)14-27(19)37/h11-18,29H,4-10H2,1-3H3,(H,33,38)
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n/an/a 11n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448591
PNG
(5-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)...)
Show SMILES CNC(=O)c1c[nH]c2c(cc(cc12)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F)C(C)C
Show InChI InChI=1S/C27H29F2N5O/c1-15(2)19-9-18(10-21-23(27(35)30-3)13-31-25(19)21)34-7-5-6-16-8-20(17-12-32-33(4)14-17)22(26(28)29)11-24(16)34/h8-15,26,31H,5-7H2,1-4H3,(H,30,35)
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n/an/a 12n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448567
PNG
(US10696655, Example 39)
Show SMILES Cn1cc(cn1)-c1cc2CCCN(c3cc(C4CCC4)c4n(C)c(=O)n(C)c4c3)c2cc1C(F)F
Show InChI InChI=1S/C27H29F2N5O/c1-31-15-18(14-30-31)20-10-17-8-5-9-34(23(17)13-22(20)26(28)29)19-11-21(16-6-4-7-16)25-24(12-19)32(2)27(35)33(25)3/h10-16,26H,4-9H2,1-3H3
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n/an/a 12n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448635
PNG
(6-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)...)
Show SMILES Cn1cc(cn1)-c1cc2CCCN(c3cc(C#C)c4n(C)c(=O)n(C)c4c3)c2cc1C(F)F
Show InChI InChI=1S/C25H23F2N5O/c1-5-15-9-18(11-22-23(15)31(4)25(33)30(22)3)32-8-6-7-16-10-19(17-13-28-29(2)14-17)20(24(26)27)12-21(16)32/h1,9-14,24H,6-8H2,2-4H3
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n/an/a 12n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448575
PNG
(5-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)...)
Show SMILES Cc1cc2n(C)c(=O)n(C)c2cc1N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C24H25F2N5O/c1-14-8-21-22(30(4)24(32)29(21)3)11-19(14)31-7-5-6-15-9-17(16-12-27-28(2)13-16)18(23(25)26)10-20(15)31/h8-13,23H,5-7H2,1-4H3
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n/an/a 13n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50250909
PNG
(CHEMBL4076254 | US10696655, Example 113)
Show SMILES CNC(=O)N1CCOc2ccc(cc2C1)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C25H27F2N5O2/c1-28-25(33)31-8-9-34-23-6-5-19(10-17(23)15-31)32-7-3-4-16-11-20(18-13-29-30(2)14-18)21(24(26)27)12-22(16)32/h5-6,10-14,24H,3-4,7-9,15H2,1-2H3,(H,28,33)
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n/an/a 14n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448658
PNG
(N4,1-dimethyl-N3-(3-(1-methyl-1H-pyrazol-4-yl)isoq...)
Show SMILES CNC(=O)c1cn(C)nc1C(=O)Nc1cccc2cc(ncc12)-c1cnn(C)c1
Show InChI InChI=1S/C20H19N7O2/c1-21-19(28)15-11-27(3)25-18(15)20(29)24-16-6-4-5-12-7-17(22-9-14(12)16)13-8-23-26(2)10-13/h4-11H,1-3H3,(H,21,28)(H,24,29)
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n/an/a 14n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448563
PNG
(6-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)...)
Show SMILES Cc1cc(cc2n(C)c(=O)n(C)c12)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C24H25F2N5O/c1-14-8-17(10-21-22(14)30(4)24(32)29(21)3)31-7-5-6-15-9-18(16-12-27-28(2)13-16)19(23(25)26)11-20(15)31/h8-13,23H,5-7H2,1-4H3
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n/an/a 14n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448597
PNG
(US10696655, Example 68)
Show SMILES CNC(=O)c1c[nH]c2ncc(cc12)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C23H22F2N6O/c1-26-23(32)19-11-28-22-18(19)7-15(10-27-22)31-5-3-4-13-6-16(14-9-29-30(2)12-14)17(21(24)25)8-20(13)31/h6-12,21H,3-5H2,1-2H3,(H,26,32)(H,27,28)
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n/an/a 15n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448638
PNG
(5-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)...)
Show SMILES CNC(=O)c1cn(C)c2c(C)cc(cc12)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C26H27F2N5O/c1-15-8-18(10-20-22(26(34)29-2)14-31(3)24(15)20)33-7-5-6-16-9-19(17-12-30-32(4)13-17)21(25(27)28)11-23(16)33/h8-14,25H,5-7H2,1-4H3,(H,29,34)
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n/an/a 16n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448640
PNG
(5-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)...)
Show SMILES CNC(=O)c1cn(C)c2c(OC)cc(cc12)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C26H27F2N5O2/c1-29-26(34)21-14-31(2)24-19(21)9-17(10-23(24)35-4)33-7-5-6-15-8-18(16-12-30-32(3)13-16)20(25(27)28)11-22(15)33/h8-14,25H,5-7H2,1-4H3,(H,29,34)
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n/an/a 16n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448566
PNG
(US10696655, Example 38)
Show SMILES Cn1cc(cn1)-c1cc2CCCN(c3cc(C4CC4)c4n(C)c(=O)n(C)c4c3)c2cc1C(F)F
Show InChI InChI=1S/C26H27F2N5O/c1-30-14-17(13-29-30)19-9-16-5-4-8-33(22(16)12-21(19)25(27)28)18-10-20(15-6-7-15)24-23(11-18)31(2)26(34)32(24)3/h9-15,25H,4-8H2,1-3H3
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n/an/a 16n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448641
PNG
(5-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)...)
Show SMILES CNC(=O)c1cn(C)c2c(cc(cc12)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F)C(C)=C
Show InChI InChI=1S/C28H29F2N5O/c1-16(2)20-10-19(11-22-24(28(36)31-3)15-33(4)26(20)22)35-8-6-7-17-9-21(18-13-32-34(5)14-18)23(27(29)30)12-25(17)35/h9-15,27H,1,6-8H2,2-5H3,(H,31,36)
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n/an/a 16n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448599
PNG
(US10696655, Example 70)
Show SMILES CNC(=O)c1c[nH]c2cnc(nc12)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C22H21F2N7O/c1-25-21(32)16-9-26-17-10-27-22(29-19(16)17)31-5-3-4-12-6-14(13-8-28-30(2)11-13)15(20(23)24)7-18(12)31/h6-11,20,26H,3-5H2,1-2H3,(H,25,32)
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n/an/a 18n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448570
PNG
(US10696655, Example 42)
Show SMILES CNc1cc(cc2n(C)c(=O)n(C)c12)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C24H26F2N6O/c1-27-19-9-16(10-21-22(19)31(4)24(33)30(21)3)32-7-5-6-14-8-17(15-12-28-29(2)13-15)18(23(25)26)11-20(14)32/h8-13,23,27H,5-7H2,1-4H3
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n/an/a 19n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50250910
PNG
(CHEMBL4072630 | US10696655, Example 18)
Show SMILES Cn1cc(cn1)-c1cc2CCCN(c3ccc4n(C)c(=O)n(C)c4c3)c2cc1C(F)F
Show InChI InChI=1S/C23H23F2N5O/c1-27-13-15(12-26-27)17-9-14-5-4-8-30(20(14)11-18(17)22(24)25)16-6-7-19-21(10-16)29(3)23(31)28(19)2/h6-7,9-13,22H,4-5,8H2,1-3H3
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n/an/a 19n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448633
PNG
(6-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)...)
Show SMILES CCCc1cc(cc2n(C)c(=O)n(C)c12)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C26H29F2N5O/c1-5-7-17-10-19(12-23-24(17)32(4)26(34)31(23)3)33-9-6-8-16-11-20(18-14-29-30(2)15-18)21(25(27)28)13-22(16)33/h10-15,25H,5-9H2,1-4H3
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n/an/a 19n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448636
PNG
(5-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)...)
Show SMILES Cn1cc(cn1)-c1cc2CCCN(c2cc1C(F)F)c1cc2n(C)c(=O)n(C)c2cc1C#C
Show InChI InChI=1S/C25H23F2N5O/c1-5-15-10-22-23(31(4)25(33)30(22)3)12-21(15)32-8-6-7-16-9-18(17-13-28-29(2)14-17)19(24(26)27)11-20(16)32/h1,9-14,24H,6-8H2,2-4H3
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n/an/a 21n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448577
PNG
(US10696655, Example 49)
Show SMILES CNC(=O)c1cn(C)c2ccc(cc12)-c1cccc2cc(ncc12)-c1cnn(C)c1
Show InChI InChI=1S/C24H21N5O/c1-25-24(30)21-14-28(2)23-8-7-16(9-19(21)23)18-6-4-5-15-10-22(26-12-20(15)18)17-11-27-29(3)13-17/h4-14H,1-3H3,(H,25,30)
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n/an/a 22n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448611
PNG
(1-(7-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-...)
Show SMILES CCC(=O)N1CCOc2ccc(cc2C1)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C26H28F2N4O2/c1-3-25(33)31-9-10-34-24-7-6-20(11-18(24)16-31)32-8-4-5-17-12-21(19-14-29-30(2)15-19)22(26(27)28)13-23(17)32/h6-7,11-15,26H,3-5,8-10,16H2,1-2H3
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n/an/a 22n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448562
PNG
(US10696655, Example 35)
Show SMILES Cn1cc(cn1)-c1cc2CCCN(c2cc1C(F)F)c1cc2n(C)c(=O)n(C)c2cc1F
Show InChI InChI=1S/C23H22F3N5O/c1-28-12-14(11-27-28)15-7-13-5-4-6-31(18(13)8-16(15)22(25)26)19-10-21-20(9-17(19)24)29(2)23(32)30(21)3/h7-12,22H,4-6H2,1-3H3
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n/an/a 23n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448650
PNG
(5-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)...)
Show SMILES CN1Cc2c(NC1=O)cccc2N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C23H23F2N5O/c1-28-13-18-19(27-23(28)31)6-3-7-20(18)30-8-4-5-14-9-16(15-11-26-29(2)12-15)17(22(24)25)10-21(14)30/h3,6-7,9-12,22H,4-5,8,13H2,1-2H3,(H,27,31)
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n/an/a 26n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448590
PNG
(US10696655, Example 61)
Show SMILES CNC(=O)c1cn(C)c2cnc(nc12)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C23H23F2N7O/c1-26-22(33)17-12-30(2)19-10-27-23(29-20(17)19)32-6-4-5-13-7-15(14-9-28-31(3)11-14)16(21(24)25)8-18(13)32/h7-12,21H,4-6H2,1-3H3,(H,26,33)
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n/an/a 26n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448573
PNG
(US10696655, Example 44)
Show SMILES Cn1cc(cn1)-c1cc2CCCN(c3cc(N4CCCCC4)c4n(C)c(=O)n(C)c4c3)c2cc1C(F)F
Show InChI InChI=1S/C28H32F2N6O/c1-32-17-19(16-31-32)21-12-18-8-7-11-36(23(18)15-22(21)27(29)30)20-13-24-26(34(3)28(37)33(24)2)25(14-20)35-9-5-4-6-10-35/h12-17,27H,4-11H2,1-3H3
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n/an/a 26n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448579
PNG
(US10696655, Example 51)
Show SMILES CCn1cc(C(=O)NC)c2cc(ccc12)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C26H27F2N5O/c1-4-32-15-22(26(34)29-2)20-11-18(7-8-23(20)32)33-9-5-6-16-10-19(17-13-30-31(3)14-17)21(25(27)28)12-24(16)33/h7-8,10-15,25H,4-6,9H2,1-3H3,(H,29,34)
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n/an/a 27n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448629
PNG
(1,3-dimethyl-5-(4-methyl-6-(1-methyl-1H-pyrazol-4-...)
Show SMILES CN1CCN(c2ccc3n(C)c(=O)n(C)c3c2)c2cc(c(cc12)-c1cnn(C)c1)C(F)(F)F
Show InChI InChI=1S/C23H23F3N6O/c1-28-7-8-32(15-5-6-18-20(9-15)31(4)22(33)30(18)3)21-11-17(23(24,25)26)16(10-19(21)28)14-12-27-29(2)13-14/h5-6,9-13H,7-8H2,1-4H3
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n/an/a 30n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448642
PNG
(5-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)...)
Show SMILES CNC(=O)c1cn(C)c2c(cc(cc12)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F)C(C)C
Show InChI InChI=1S/C28H31F2N5O/c1-16(2)20-10-19(11-22-24(28(36)31-3)15-33(4)26(20)22)35-8-6-7-17-9-21(18-13-32-34(5)14-18)23(27(29)30)12-25(17)35/h9-16,27H,6-8H2,1-5H3,(H,31,36)
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n/an/a 31n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448624
PNG
(6-[7-(difluoromethyl)-6-(1-methylpyrazol-4-yl)-3,4...)
Show SMILES CN1C(=O)Cc2ccc(cc12)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C23H22F2N4O/c1-27-13-16(12-26-27)18-8-14-4-3-7-29(21(14)11-19(18)23(24)25)17-6-5-15-9-22(30)28(2)20(15)10-17/h5-6,8,10-13,23H,3-4,7,9H2,1-2H3
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n/an/a 32n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448646
PNG
(1-(7-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-...)
Show SMILES CC(=O)N1CCOc2ccc(cc2C1)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C25H26F2N4O2/c1-16(32)30-8-9-33-24-6-5-20(10-18(24)15-30)31-7-3-4-17-11-21(19-13-28-29(2)14-19)22(25(26)27)12-23(17)31/h5-6,10-14,25H,3-4,7-9,15H2,1-2H3
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n/an/a 32n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50250907
PNG
(CHEMBL4095016 | US10696655, Example 19)
Show SMILES CN1C(=O)CCc2ccc(cc12)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C24H24F2N4O/c1-28-14-17(13-27-28)19-10-16-4-3-9-30(22(16)12-20(19)24(25)26)18-7-5-15-6-8-23(31)29(2)21(15)11-18/h5,7,10-14,24H,3-4,6,8-9H2,1-2H3
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n/an/a 33n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448653
PNG
(4-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)...)
Show SMILES CNC(=O)c1ccc2cncc(N3CCCc4cc(-c5cnn(C)c5)c(cc34)C(F)F)c2c1
Show InChI InChI=1S/C25H23F2N5O/c1-28-25(33)16-5-6-17-11-29-13-23(20(17)9-16)32-7-3-4-15-8-19(18-12-30-31(2)14-18)21(24(26)27)10-22(15)32/h5-6,8-14,24H,3-4,7H2,1-2H3,(H,28,33)
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n/an/a 34n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50250898
PNG
(CHEMBL4059634 | US10696655, Example 27)
Show SMILES CNC(=O)c1ccc2nccc(N3CCCc4cc(-c5cnn(C)c5)c(cc34)C(F)F)c2c1
Show InChI InChI=1S/C25H23F2N5O/c1-28-25(33)16-5-6-21-20(11-16)22(7-8-29-21)32-9-3-4-15-10-18(17-13-30-31(2)14-17)19(24(26)27)12-23(15)32/h5-8,10-14,24H,3-4,9H2,1-2H3,(H,28,33)
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n/an/a 34n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448552
PNG
(US10696655, Example 25)
Show SMILES Cn1cc(cn1)-c1cc2CCCN(c3cnc4n(C)c(=O)n(C)c4c3)c2cc1C(F)F
Show InChI InChI=1S/C22H22F2N6O/c1-27-12-14(10-26-27)16-7-13-5-4-6-30(18(13)9-17(16)20(23)24)15-8-19-21(25-11-15)29(3)22(31)28(19)2/h7-12,20H,4-6H2,1-3H3
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n/an/a 38n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448576
PNG
(US10696655, Example 47)
Show SMILES CCc1cc2n(C)c(=O)n(C)c2cc1N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C25H27F2N5O/c1-5-15-10-22-23(31(4)25(33)30(22)3)12-21(15)32-8-6-7-16-9-18(17-13-28-29(2)14-17)19(24(26)27)11-20(16)32/h9-14,24H,5-8H2,1-4H3
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n/an/a 39n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448651
PNG
((S)-2-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4...)
Show SMILES CNC(=O)[C@H]1CCc2ccc(nc12)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C24H25F2N5O/c1-27-24(32)17-7-5-14-6-8-21(29-22(14)17)31-9-3-4-15-10-18(16-12-28-30(2)13-16)19(23(25)26)11-20(15)31/h6,8,10-13,17,23H,3-5,7,9H2,1-2H3,(H,27,32)/t17-/m0/s1
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n/an/a 40n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448626
PNG
((S)-6-[7-(difluoromethyl)-6-(1-methylpyrazol-4-yl)...)
Show SMILES C[C@@H]1C(=O)N(C)c2cc(ccc12)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C24H24F2N4O/c1-14-18-7-6-17(10-22(18)29(3)24(14)31)30-8-4-5-15-9-19(16-12-27-28(2)13-16)20(23(25)26)11-21(15)30/h6-7,9-14,23H,4-5,8H2,1-3H3/t14-/m0/s1
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n/an/a 42n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448560
PNG
(4-chloro-6-(7-(difluoromethyl)-6-(1-methyl-1H-pyra...)
Show SMILES Cn1cc(cn1)-c1cc2CCCN(c3cc(Cl)c4n(C)c(=O)n(C)c4c3)c2cc1C(F)F
Show InChI InChI=1S/C23H22ClF2N5O/c1-28-12-14(11-27-28)16-7-13-5-4-6-31(19(13)10-17(16)22(25)26)15-8-18(24)21-20(9-15)29(2)23(32)30(21)3/h7-12,22H,4-6H2,1-3H3
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n/an/a 42n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50250905
PNG
(CHEMBL4097991 | US10696655, Example 17)
Show SMILES CC(=O)N1CCc2c(C1)cc(N1CCCc3cc(-c4cnn(C)c4)c(cc13)C(F)F)c(=O)n2C
Show InChI InChI=1S/C25H27F2N5O2/c1-15(33)31-8-6-21-17(14-31)10-23(25(34)30(21)3)32-7-4-5-16-9-19(18-12-28-29(2)13-18)20(24(26)27)11-22(16)32/h9-13,24H,4-8,14H2,1-3H3
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n/an/a 47n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448581
PNG
(US10696655, Example 53)
Show SMILES CNC(=O)c1c[nH]c2ccc(cc12)N1CCCc2cc(ccc12)-c1cnn(C)c1
Show InChI InChI=1S/C23H23N5O/c1-24-23(29)20-13-25-21-7-6-18(11-19(20)21)28-9-3-4-16-10-15(5-8-22(16)28)17-12-26-27(2)14-17/h5-8,10-14,25H,3-4,9H2,1-2H3,(H,24,29)
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n/an/a 48n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448559
PNG
(US10696655, Example 32)
Show SMILES CCn1c2cc(ccc2n(C)c1=O)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C24H25F2N5O/c1-4-30-22-11-17(7-8-20(22)29(3)24(30)32)31-9-5-6-15-10-18(16-13-27-28(2)14-16)19(23(25)26)12-21(15)31/h7-8,10-14,23H,4-6,9H2,1-3H3
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n/an/a 48n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448648
PNG
(7-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)...)
Show SMILES CNC(=O)N1CC(C)Oc2ccc(cc2C1)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C26H29F2N5O2/c1-16-13-32(26(34)29-2)15-18-9-20(6-7-24(18)35-16)33-8-4-5-17-10-21(19-12-30-31(3)14-19)22(25(27)28)11-23(17)33/h6-7,9-12,14,16,25H,4-5,8,13,15H2,1-3H3,(H,29,34)
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n/an/a 51n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448530
PNG
(7-(1,5-dimethylindazol-4-yl)-N-methyl-3,5-dihydro-...)
Show SMILES CNC(=O)N1CCOc2ccc(cc2C1)-c1c(C)ccc2n(C)ncc12
Show InChI InChI=1S/C20H22N4O2/c1-13-4-6-17-16(11-22-23(17)3)19(13)14-5-7-18-15(10-14)12-24(8-9-26-18)20(25)21-2/h4-7,10-11H,8-9,12H2,1-3H3,(H,21,25)
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n/an/a 57n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448539
PNG
(US10696655, Example 12)
Show SMILES CNC(=O)N1CCOc2ccc(cc2C1)-c1c(F)ccc2[nH]ccc12
Show InChI InChI=1S/C19H18FN3O2/c1-21-19(24)23-8-9-25-17-5-2-12(10-13(17)11-23)18-14-6-7-22-16(14)4-3-15(18)20/h2-7,10,22H,8-9,11H2,1H3,(H,21,24)
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n/an/a 59n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448583
PNG
(7-chloro-5-(7-(difluoromethyl)-6-(1-methyl-1H-pyra...)
Show SMILES CNC(=O)c1cn(C)c2c(Cl)cc(cc12)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C25H24ClF2N5O/c1-29-25(34)20-13-31(2)23-18(20)8-16(9-21(23)26)33-6-4-5-14-7-17(15-11-30-32(3)12-15)19(24(27)28)10-22(14)33/h7-13,24H,4-6H2,1-3H3,(H,29,34)
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n/an/a 59n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50250897
PNG
(CHEMBL4081585 | US10696655, Example 21)
Show SMILES Cn1cc(cn1)-c1cc2CCCN(c3ccc4sc(=O)n(C)c4c3)c2cc1C(F)F
Show InChI InChI=1S/C22H20F2N4OS/c1-26-12-14(11-25-26)16-8-13-4-3-7-28(18(13)10-17(16)21(23)24)15-5-6-20-19(9-15)27(2)22(29)30-20/h5-6,8-12,21H,3-4,7H2,1-2H3
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n/an/a 64n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
CREB-binding protein


(Homo sapiens (Human))
BDBM448568
PNG
(US10696655, Example 40)
Show SMILES Cc1c(ccc2n(C)c(=O)n(C)c12)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C24H25F2N5O/c1-14-19(7-8-20-22(14)30(4)24(32)29(20)3)31-9-5-6-15-10-17(16-12-27-28(2)13-16)18(23(25)26)11-21(15)31/h7-8,10-13,23H,5-6,9H2,1-4H3
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n/an/a 72n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448612
PNG
(US10696655, Example 79)
Show SMILES CCC(=O)N1CCOc2ccc(cc2C1)N1CCCc2cc(ccc12)-c1cnn(C)c1
Show InChI InChI=1S/C25H28N4O2/c1-3-25(30)28-11-12-31-24-9-7-22(14-20(24)17-28)29-10-4-5-19-13-18(6-8-23(19)29)21-15-26-27(2)16-21/h6-9,13-16H,3-5,10-12,17H2,1-2H3
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n/an/a 77n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448649
PNG
((R)-8-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4...)
Show SMILES C[C@H]1Oc2c(NC1=O)cccc2N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C23H22F2N4O2/c1-13-23(30)27-18-6-3-7-19(21(18)31-13)29-8-4-5-14-9-16(15-11-26-28(2)12-15)17(22(24)25)10-20(14)29/h3,6-7,9-13,22H,4-5,8H2,1-2H3,(H,27,30)/t13-/m1/s1
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n/an/a 77n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448623
PNG
(6-[7-(difluoromethyl)-6-(1-methylpyrazol-4-yl)-3,4...)
Show SMILES CN1C(=O)C(=O)c2ccc(cc12)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C23H20F2N4O2/c1-27-12-14(11-26-27)17-8-13-4-3-7-29(19(13)10-18(17)22(24)25)15-5-6-16-20(9-15)28(2)23(31)21(16)30/h5-6,8-12,22H,3-4,7H2,1-2H3
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n/an/a 78n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448536
PNG
(US10696655, Example 9)
Show SMILES CNC(=O)N1CCOc2ccc(cc2C1)-c1c(C)ccc(N)c1C=N
Show InChI InChI=1S/C19H22N4O2/c1-12-3-5-16(21)15(10-20)18(12)13-4-6-17-14(9-13)11-23(7-8-25-17)19(24)22-2/h3-6,9-10,20H,7-8,11,21H2,1-2H3,(H,22,24)
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n/an/a 78n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448602
PNG
(US10696655, Example 73)
Show SMILES CNC(=O)c1coc2ccc(cc12)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C24H22F2N4O2/c1-27-24(31)20-13-32-22-6-5-16(9-18(20)22)30-7-3-4-14-8-17(15-11-28-29(2)12-15)19(23(25)26)10-21(14)30/h5-6,8-13,23H,3-4,7H2,1-2H3,(H,27,31)
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n/an/a 80n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448620
PNG
(7-[2-(4-methoxyphenyl)imidazo[1,2-a]pyridin-5-yl]-...)
Show SMILES CNC(=O)N1CCOc2ccc(cc2C1)-c1cccc2nc(cn12)-c1ccc(OC)cc1
Show InChI InChI=1S/C25H24N4O3/c1-26-25(30)28-12-13-32-23-11-8-18(14-19(23)15-28)22-4-3-5-24-27-21(16-29(22)24)17-6-9-20(31-2)10-7-17/h3-11,14,16H,12-13,15H2,1-2H3,(H,26,30)
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n/an/a 81n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448617
PNG
(US10696655, Example 84)
Show SMILES CN\C=C(/C=N)c1ccc2N(CCCc2c1)C(=N)c1cc(ccc1NC1CCOCC1)C(=O)NC
Show InChI InChI=1S/C27H34N6O2/c1-30-17-21(16-28)18-6-8-25-19(14-18)4-3-11-33(25)26(29)23-15-20(27(34)31-2)5-7-24(23)32-22-9-12-35-13-10-22/h5-8,14-17,22,28-30,32H,3-4,9-13H2,1-2H3,(H,31,34)/b21-17+,28-16?,29-26?
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n/an/a 87n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448656
PNG
(1-(6-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-...)
Show SMILES CNC(=O)Nc1cccc(n1)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C21H22F2N6O/c1-24-21(30)27-18-6-3-7-19(26-18)29-8-4-5-13-9-15(14-11-25-28(2)12-14)16(20(22)23)10-17(13)29/h3,6-7,9-12,20H,4-5,8H2,1-2H3,(H2,24,26,27,30)
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n/an/a 88n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448628
PNG
(1,3-dimethyl-5-(3-(1-methyl-1H-pyrazol-4-yl)isoqui...)
Show SMILES Cn1cc(cn1)-c1cc2cccc(-c3ccc4n(C)c(=O)n(C)c4c3)c2cn1
Show InChI InChI=1S/C22H19N5O/c1-25-13-16(11-24-25)19-9-14-5-4-6-17(18(14)12-23-19)15-7-8-20-21(10-15)27(3)22(28)26(20)2/h4-13H,1-3H3
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n/an/a 90n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448627
PNG
((S)-6-[7-(difluoromethyl)-6-(1-methylpyrazol-4-yl)...)
Show SMILES C[C@H]1C(=O)N(C)c2cc(ccc12)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C24H24F2N4O/c1-14-18-7-6-17(10-22(18)29(3)24(14)31)30-8-4-5-15-9-19(16-12-27-28(2)13-16)20(23(25)26)11-21(15)30/h6-7,9-14,23H,4-5,8H2,1-3H3/t14-/m1/s1
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n/an/a 95n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448537
PNG
(US10696655, Example 10)
Show SMILES CNC(=O)N1CCOc2ccc(cc2C1)-c1cccc(NC)c1C=N
Show InChI InChI=1S/C19H22N4O2/c1-21-17-5-3-4-15(16(17)11-20)13-6-7-18-14(10-13)12-23(8-9-25-18)19(24)22-2/h3-7,10-11,20-21H,8-9,12H2,1-2H3,(H,22,24)
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n/an/a 96n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448541
PNG
(US10696655, Example 14)
Show SMILES CNC(=O)N1CCOc2ccc(cc2C1)-c1cccc(N)c1C=N
Show InChI InChI=1S/C18H20N4O2/c1-21-18(23)22-7-8-24-17-6-5-12(9-13(17)11-22)14-3-2-4-16(20)15(14)10-19/h2-6,9-10,19H,7-8,11,20H2,1H3,(H,21,23)
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n/an/a 102n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448614
PNG
(US10696655, Example 81)
Show SMILES CN\C=C(/C=N)c1cc2CCCN(c3cccc4NC(=O)[C@@H](C)Nc34)c2cc1C(F)F
Show InChI InChI=1S/C23H25F2N5O/c1-13-23(31)29-18-6-3-7-19(21(18)28-13)30-8-4-5-14-9-16(15(11-26)12-27-2)17(22(24)25)10-20(14)30/h3,6-7,9-13,22,26-28H,4-5,8H2,1-2H3,(H,29,31)/b15-12+,26-11?/t13-/m1/s1
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n/an/a 102n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448551
PNG
(US10696655, Example 24)
Show SMILES Cn1cc(cn1)-c1cc2CCCN(c3cc4n(C)c(=O)n(C)c4cn3)c2cc1C(F)F
Show InChI InChI=1S/C22H22F2N6O/c1-27-12-14(10-26-27)15-7-13-5-4-6-30(17(13)8-16(15)21(23)24)20-9-18-19(11-25-20)29(3)22(31)28(18)2/h7-12,21H,4-6H2,1-3H3
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n/an/a 106n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448603
PNG
(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-1-...)
Show SMILES Cn1cc(cn1)-c1c[nH]c2ncc(nc12)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C24H22F2N8/c1-32-12-15(8-29-32)17-6-14-4-3-5-34(20(14)7-18(17)23(25)26)21-11-28-24-22(31-21)19(10-27-24)16-9-30-33(2)13-16/h6-13,23H,3-5H2,1-2H3,(H,27,28)
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n/an/a 108n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448601
PNG
(6-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)...)
Show SMILES CNC(=O)c1cnc2ccc(nn12)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C22H21F2N7O/c1-25-22(32)18-11-26-19-5-6-20(28-31(18)19)30-7-3-4-13-8-15(14-10-27-29(2)12-14)16(21(23)24)9-17(13)30/h5-6,8-12,21H,3-4,7H2,1-2H3,(H,25,32)
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n/an/a 110n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50250908
PNG
(CHEMBL4068063 | US10696655, Example 123)
Show SMILES CNC(=O)Nc1cc(OC)cc(n1)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C22H24F2N6O2/c1-25-22(31)28-19-8-15(32-3)9-20(27-19)30-6-4-5-13-7-16(14-11-26-29(2)12-14)17(21(23)24)10-18(13)30/h7-12,21H,4-6H2,1-3H3,(H2,25,27,28,31)
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n/an/a 115n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448556
PNG
(US10696655, Example 29)
Show SMILES CNC(=O)c1ccc2nccc(N3CCCc4cc(ccc34)-c3cnn(C)c3)c2c1
Show InChI InChI=1S/C24H23N5O/c1-25-24(30)18-5-7-21-20(13-18)23(9-10-26-21)29-11-3-4-17-12-16(6-8-22(17)29)19-14-27-28(2)15-19/h5-10,12-15H,3-4,11H2,1-2H3,(H,25,30)
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n/an/a 160n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448558
PNG
(5-[7-(difluoromethyl)-6-(1-methylpyrazol-4-yl)-3,4...)
Show SMILES CCn1c2ccc(cc2n(C)c1=O)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C24H25F2N5O/c1-4-30-20-8-7-17(11-22(20)29(3)24(30)32)31-9-5-6-15-10-18(16-13-27-28(2)14-16)19(23(25)26)12-21(15)31/h7-8,10-14,23H,4-6,9H2,1-3H3
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n/an/a 172n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448660
PNG
(3-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)...)
Show SMILES CNC(=O)C1CCc2c(C1)c(nn2C1CCOCC1)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C28H34F2N6O2/c1-31-28(37)18-5-6-24-23(13-18)27(33-36(24)20-7-10-38-11-8-20)35-9-3-4-17-12-21(19-15-32-34(2)16-19)22(26(29)30)14-25(17)35/h12,14-16,18,20,26H,3-11,13H2,1-2H3,(H,31,37)
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n/an/a 184n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448607
PNG
(US10696655, Example 77)
Show SMILES CNC(=O)N1CCOc2ccc(cc2C1)-c1cccc(-c2cnn(C)c2)c1C(F)F
Show InChI InChI=1S/C22H22F2N4O2/c1-25-22(29)28-8-9-30-19-7-6-14(10-15(19)13-28)17-4-3-5-18(20(17)21(23)24)16-11-26-27(2)12-16/h3-7,10-12,21H,8-9,13H2,1-2H3,(H,25,29)
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n/an/a 187n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448528
PNG
(7-(isoquinolin-1-yl)-N-methyl-2,3-dihydrobenzo[f][...)
Show SMILES CNC(=O)N1CCOc2ccc(cc2C1)-c1nccc2ccccc12
Show InChI InChI=1S/C20H19N3O2/c1-21-20(24)23-10-11-25-18-7-6-15(12-16(18)13-23)19-17-5-3-2-4-14(17)8-9-22-19/h2-9,12H,10-11,13H2,1H3,(H,21,24)
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n/an/a 187n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448600
PNG
(US10696655, Example 71)
Show SMILES CNC(=O)c1n[nH]c2ccc(nc12)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C22H21F2N7O/c1-25-22(32)20-19-16(28-29-20)5-6-18(27-19)31-7-3-4-12-8-14(13-10-26-30(2)11-13)15(21(23)24)9-17(12)31/h5-6,8-11,21H,3-4,7H2,1-2H3,(H,25,32)(H,28,29)
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n/an/a 187n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448531
PNG
(US10696655, Example 4)
Show SMILES CNC(=O)N1CCOc2ccc(cc2C1)-c1ccnc2ccccc12
Show InChI InChI=1S/C20H19N3O2/c1-21-20(24)23-10-11-25-19-7-6-14(12-15(19)13-23)16-8-9-22-18-5-3-2-4-17(16)18/h2-9,12H,10-11,13H2,1H3,(H,21,24)
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n/an/a 193n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448555
PNG
(US10696655, Example 28)
Show SMILES COC(=O)c1ccc2nccc(N3CCCc4cc(ccc34)-c3cnn(C)c3)c2c1
Show InChI InChI=1S/C24H22N4O2/c1-27-15-19(14-26-27)16-6-8-22-17(12-16)4-3-11-28(22)23-9-10-25-21-7-5-18(13-20(21)23)24(29)30-2/h5-10,12-15H,3-4,11H2,1-2H3
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n/an/a 199n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448644
PNG
(9-isopropyl-N-methyl-7-(o-tolyl)-2,3-dihydrobenzo[...)
Show SMILES CNC(=O)N1CCOc2c(C1)cc(cc2C(C)C)-c1ccccc1C
Show InChI InChI=1S/C21H26N2O2/c1-14(2)19-12-16(18-8-6-5-7-15(18)3)11-17-13-23(21(24)22-4)9-10-25-20(17)19/h5-8,11-12,14H,9-10,13H2,1-4H3,(H,22,24)
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n/an/a 201n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448613
PNG
((S)-5-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4...)
Show SMILES C[C@@H]1Nc2c(NC1=O)cccc2N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C23H23F2N5O/c1-13-23(31)28-18-6-3-7-19(21(18)27-13)30-8-4-5-14-9-16(15-11-26-29(2)12-15)17(22(24)25)10-20(14)30/h3,6-7,9-13,22,27H,4-5,8H2,1-2H3,(H,28,31)/t13-/m0/s1
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n/an/a 206n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448637
PNG
(N,1-dimethyl-3-(3-(1-methyl-1H-pyrazol-4-yl)isoqui...)
Show SMILES CNC(=O)c1ccc2n(C)c(=O)n(-c3cccc4cc(ncc34)-c3cnn(C)c3)c2c1
Show InChI InChI=1S/C23H20N6O2/c1-24-22(30)15-7-8-20-21(10-15)29(23(31)28(20)3)19-6-4-5-14-9-18(25-12-17(14)19)16-11-26-27(2)13-16/h4-13H,1-3H3,(H,24,30)
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n/an/a 222n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448606
PNG
(7-(2-(difluoromethyl)-6-methyl-3-(1-methyl-1H-pyra...)
Show SMILES CNC(=O)N1CCOc2ccc(cc2C1)-c1c(C)ccc(-c2cnn(C)c2)c1C(F)F
Show InChI InChI=1S/C23H24F2N4O2/c1-14-4-6-18(17-11-27-28(3)12-17)21(22(24)25)20(14)15-5-7-19-16(10-15)13-29(8-9-31-19)23(30)26-2/h4-7,10-12,22H,8-9,13H2,1-3H3,(H,26,30)
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n/an/a 243n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448604
PNG
(US10696655, Example 75)
Show SMILES Cn1cc(cn1)-c1c[nH]c2ncc(nc12)N1CCCc2cc(ccc12)-c1cnn(C)c1
Show InChI InChI=1S/C23H22N8/c1-29-13-17(9-26-29)15-5-6-20-16(8-15)4-3-7-31(20)21-12-25-23-22(28-21)19(11-24-23)18-10-27-30(2)14-18/h5-6,8-14H,3-4,7H2,1-2H3,(H,24,25)
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n/an/a 244n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448622
PNG
(6-acetyl-1-methyl-3-[3-(1-methylpyrazol-4-yl)-8-is...)
Show SMILES CC(=O)N1CCc2c(C1)cc(-c1cccc3cc(ncc13)-c1cnn(C)c1)c(=O)n2C
Show InChI InChI=1S/C24H23N5O2/c1-15(30)29-8-7-23-17(14-29)9-20(24(31)28(23)3)19-6-4-5-16-10-22(25-12-21(16)19)18-11-26-27(2)13-18/h4-6,9-13H,7-8,14H2,1-3H3
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n/an/a 258n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448540
PNG
(US10696655, Example 13)
Show SMILES CNC(=O)N1CCOc2ccc(cc2C1)-c1ccc2[nH]ccc2c1
Show InChI InChI=1S/C19H19N3O2/c1-20-19(23)22-8-9-24-18-5-3-14(11-16(18)12-22)13-2-4-17-15(10-13)6-7-21-17/h2-7,10-11,21H,8-9,12H2,1H3,(H,20,23)
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n/an/a 267n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448534
PNG
(US10696655, Example 7)
Show SMILES CNC(=O)N1CCOc2ccc(cc2C1)-c1cc(C)ccc1C
Show InChI InChI=1S/C19H22N2O2/c1-13-4-5-14(2)17(10-13)15-6-7-18-16(11-15)12-21(8-9-23-18)19(22)20-3/h4-7,10-11H,8-9,12H2,1-3H3,(H,20,22)
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n/an/a 273n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448643
PNG
(9-ethyl-N-methyl-7-(o-tolyl)-2,3-dihydrobenzo[f][1...)
Show SMILES CCc1cc(cc2CN(CCOc12)C(=O)NC)-c1ccccc1C
Show InChI InChI=1S/C20H24N2O2/c1-4-15-11-16(18-8-6-5-7-14(18)2)12-17-13-22(20(23)21-3)9-10-24-19(15)17/h5-8,11-12H,4,9-10,13H2,1-3H3,(H,21,23)
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n/an/a 273n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448655
PNG
(N-methyl-2-(3-(1-methyl-1H-pyrazol-4-yl)isoquinoli...)
Show SMILES CNC(=O)c1cccc2oc(nc12)-c1cccc2cc(ncc12)-c1cnn(C)c1
Show InChI InChI=1S/C22H17N5O2/c1-23-21(28)16-7-4-8-19-20(16)26-22(29-19)15-6-3-5-13-9-18(24-11-17(13)15)14-10-25-27(2)12-14/h3-12H,1-2H3,(H,23,28)
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n/an/a 274n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448538
PNG
(US10696655, Example 11)
Show SMILES CNC(=O)N1CCOc2ccc(cc2C1)-c1cncc2ccccc12
Show InChI InChI=1S/C20H19N3O2/c1-21-20(24)23-8-9-25-19-7-6-14(10-16(19)13-23)18-12-22-11-15-4-2-3-5-17(15)18/h2-7,10-12H,8-9,13H2,1H3,(H,21,24)
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n/an/a 281n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448532
PNG
(US10696655, Example 5)
Show SMILES CN\C=C1/C(=N)C=CC=C1c1ccc2OCCN(Cc2c1)C(=O)NC
Show InChI InChI=1S/C19H22N4O2/c1-21-11-16-15(4-3-5-17(16)20)13-6-7-18-14(10-13)12-23(8-9-25-18)19(24)22-2/h3-7,10-11,20-21H,8-9,12H2,1-2H3,(H,22,24)/b16-11-,20-17?
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n/an/a 296n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448550
PNG
(US10696655, Example 23)
Show SMILES Cn1cc(cn1)-c1ccc2N(CCCc2c1)c1ccc2sc(=O)n(C)c2c1
Show InChI InChI=1S/C21H20N4OS/c1-23-13-16(12-22-23)14-5-7-18-15(10-14)4-3-9-25(18)17-6-8-20-19(11-17)24(2)21(26)27-20/h5-8,10-13H,3-4,9H2,1-2H3
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n/an/a 317n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448529
PNG
(US10696655, Example 2)
Show SMILES CNC(=O)N1CCOc2ccc(cc2C1)-c1nc(N)cc2cnccc12
Show InChI InChI=1S/C19H19N5O2/c1-21-19(25)24-6-7-26-16-3-2-12(8-14(16)11-24)18-15-4-5-22-10-13(15)9-17(20)23-18/h2-5,8-10H,6-7,11H2,1H3,(H2,20,23)(H,21,25)
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n/an/a 321n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448615
PNG
(US10696655, Example 82)
Show SMILES CN\C=C(/C=N)c1ccc2N(CCCc2c1)c1cccc2NC(=O)[C@@H](C)Nc12
Show InChI InChI=1S/C22H25N5O/c1-14-22(28)26-18-6-3-7-20(21(18)25-14)27-10-4-5-16-11-15(8-9-19(16)27)17(12-23)13-24-2/h3,6-9,11-14,23-25H,4-5,10H2,1-2H3,(H,26,28)/b17-13+,23-12?/t14-/m1/s1
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n/an/a 325n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448533
PNG
(US10696655, Example 6)
Show SMILES CNC(=O)N1CCOc2ccc(cc2C1)-c1cccc2ncccc12
Show InChI InChI=1S/C20H19N3O2/c1-21-20(24)23-10-11-25-19-8-7-14(12-15(19)13-23)16-4-2-6-18-17(16)5-3-9-22-18/h2-9,12H,10-11,13H2,1H3,(H,21,24)
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n/an/a 362n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448542
PNG
(US10696655, Example 15)
Show SMILES CNC(=O)N1CCOc2ccc(cc2C1)-c1cccc2cn[nH]c12
Show InChI InChI=1S/C18H18N4O2/c1-19-18(23)22-7-8-24-16-6-5-12(9-14(16)11-22)15-4-2-3-13-10-20-21-17(13)15/h2-6,9-10H,7-8,11H2,1H3,(H,19,23)(H,20,21)
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n/an/a 391n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448535
PNG
(US10696655, Example 8)
Show SMILES CNC(=O)N1CCOc2ccc(cc2C1)-c1cccc2cnn(C)c12
Show InChI InChI=1S/C19H20N4O2/c1-20-19(24)23-8-9-25-17-7-6-13(10-15(17)12-23)16-5-3-4-14-11-21-22(2)18(14)16/h3-7,10-11H,8-9,12H2,1-2H3,(H,20,24)
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n/an/a 394n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448645
PNG
(9-methoxy-N-methyl-7-(o-tolyl)-2,3-dihydrobenzo[f]...)
Show SMILES CNC(=O)N1CCOc2c(C1)cc(cc2OC)-c1ccccc1C
Show InChI InChI=1S/C19H22N2O3/c1-13-6-4-5-7-16(13)14-10-15-12-21(19(22)20-2)8-9-24-18(15)17(11-14)23-3/h4-7,10-11H,8-9,12H2,1-3H3,(H,20,22)
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n/an/a 409n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50250890
PNG
(CHEMBL4086422 | US10696655, Example 87)
Show SMILES CC(=O)N1CCCc2cc(ccc12)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C25H26F2N4O/c1-16(32)30-9-3-5-17-11-20(7-8-23(17)30)31-10-4-6-18-12-21(19-14-28-29(2)15-19)22(25(26)27)13-24(18)31/h7-8,11-15,25H,3-6,9-10H2,1-2H3
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n/an/a 429n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448618
PNG
(N,1-dimethyl-7-(o-tolyl)-3,5-dihydro-2H-1,4-benzod...)
Show SMILES CNC(=O)N1CCN(C)c2ccc(cc2C1)-c1ccccc1C
Show InChI InChI=1S/C19H23N3O/c1-14-6-4-5-7-17(14)15-8-9-18-16(12-15)13-22(19(23)20-2)11-10-21(18)3/h4-9,12H,10-11,13H2,1-3H3,(H,20,23)
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n/an/a 450n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448625
PNG
(5-[7-(difluoromethyl)-6-(1-methylpyrazol-4-yl)-3,4...)
Show SMILES Cn1cc(cn1)-c1cc2CCCN(c3ccc4oc(=O)n(C)c4c3)c2cc1C(F)F
Show InChI InChI=1S/C22H20F2N4O2/c1-26-12-14(11-25-26)16-8-13-4-3-7-28(18(13)10-17(16)21(23)24)15-5-6-20-19(9-15)27(2)22(29)30-20/h5-6,8-12,21H,3-4,7H2,1-2H3
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n/an/a 481n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448557
PNG
(US10696655, Example 30)
Show SMILES CNC(=O)c1cnn2ccc(cc12)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C23H22F2N6O/c1-26-23(32)19-12-28-31-7-5-16(9-21(19)31)30-6-3-4-14-8-17(15-11-27-29(2)13-15)18(22(24)25)10-20(14)30/h5,7-13,22H,3-4,6H2,1-2H3,(H,26,32)
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n/an/a 543n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448549
PNG
(US10696655, Example 22)
Show SMILES Cn1cc(cn1)-c1cc2CCCN(c3ccc4n(C)c(=O)sc4c3)c2cc1C(F)F
Show InChI InChI=1S/C22H20F2N4OS/c1-26-12-14(11-25-26)16-8-13-4-3-7-28(19(13)10-17(16)21(23)24)15-5-6-18-20(9-15)30-22(29)27(18)2/h5-6,8-12,21H,3-4,7H2,1-2H3
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n/an/a 1.69E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448547
PNG
(US10696655, Example 20)
Show SMILES CN1C(=O)C(C)(C)c2ccc(cc12)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C25H26F2N4O/c1-25(2)20-8-7-17(11-22(20)30(4)24(25)32)31-9-5-6-15-10-18(16-13-28-29(3)14-16)19(23(26)27)12-21(15)31/h7-8,10-14,23H,5-6,9H2,1-4H3
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n/an/a 1.75E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448553
PNG
(US10696655, Example 26)
Show SMILES Cn1cc(cn1)-c1cc2CCCN(c3ccc4n(C)c(=O)n(C)c4n3)c2cc1C(F)F
Show InChI InChI=1S/C22H22F2N6O/c1-27-12-14(11-25-27)15-9-13-5-4-8-30(18(13)10-16(15)20(23)24)19-7-6-17-21(26-19)29(3)22(31)28(17)2/h6-7,9-12,20H,4-5,8H2,1-3H3
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n/an/a 2.28E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448652
PNG
((S)-2-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4...)
Show SMILES CNC(=O)[C@@H]1CCc2ccc(nc12)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C24H25F2N5O/c1-27-24(32)17-7-5-14-6-8-21(29-22(14)17)31-9-3-4-15-10-18(16-12-28-30(2)13-16)19(23(25)26)11-20(15)31/h6,8,10-13,17,23H,3-5,7,9H2,1-2H3,(H,27,32)/t17-/m1/s1
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n/an/a 3.24E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM448561
PNG
(US10696655, Example 34)
Show SMILES Cn1cc(cn1)-c1cc2CCCN(c3ccc4n(C)c(=O)n(C)c4c3F)c2cc1C(F)F
Show InChI InChI=1S/C23H22F3N5O/c1-28-12-14(11-27-28)15-9-13-5-4-8-31(19(13)10-16(15)22(25)26)17-6-7-18-21(20(17)24)30(3)23(32)29(18)2/h6-7,9-12,22H,4-5,8H2,1-3H3
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n/an/a>4.90E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10696655 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%