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Patent code US10696661

Compile Data Set for Download or QSAR
Found 70 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448544
PNG
(N-(2-(4-(furan-2-ylmethyl)piperazin-1-yl)-5- (trif...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccco3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C26H23F3N4O3/c27-26(28,29)19-3-4-22(33-13-11-32(12-14-33)17-20-2-1-15-35-20)21(16-19)31-25(34)24-6-5-23(36-24)18-7-9-30-10-8-18/h1-10,15-16H,11-14,17H2,(H,31,34)
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US Patent
n/an/a 0.370n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448683
PNG
(N-(2-(4-(thiazol-5-ylmethyl)piperazin-1-yl)-5- (tr...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cncs3)CC2)c(NC(=O)c2ccccn2)c1
Show InChI InChI=1S/C21H20F3N5OS/c22-21(23,24)15-4-5-19(18(11-15)27-20(30)17-3-1-2-6-26-17)29-9-7-28(8-10-29)13-16-12-25-14-31-16/h1-6,11-12,14H,7-10,13H2,(H,27,30)
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US Patent
n/an/a 0.5n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448727
PNG
(5-(tetrahydro-2H-pyran-4-yl)-N-(2-(4-(thiazol-5- y...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cncs3)CC2)c(NC(=O)c2ccc(o2)C2CCOCC2)c1
Show InChI InChI=1S/C25H27F3N4O3S/c26-25(27,28)18-1-2-21(32-9-7-31(8-10-32)15-19-14-29-16-36-19)20(13-18)30-24(33)23-4-3-22(35-23)17-5-11-34-12-6-17/h1-4,13-14,16-17H,5-12,15H2,(H,30,33)
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n/an/a 0.5n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448695
PNG
(N-(2-(4-(furan-3-ylmethyl)piperazin-1-yl)-5- (trif...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccoc3)CC2)c(NC(=O)c2ccc(o2)C2CCOCC2)c1
Show InChI InChI=1S/C26H28F3N3O4/c27-26(28,29)20-1-2-22(32-10-8-31(9-11-32)16-18-5-12-35-17-18)21(15-20)30-25(33)24-4-3-23(36-24)19-6-13-34-14-7-19/h1-5,12,15,17,19H,6-11,13-14,16H2,(H,30,33)
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n/an/a 0.700n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448663
PNG
(N-(2-(4-(oxazol-5-ylmethyl)piperazin-1-yl)-5- (tri...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cnco3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C25H22F3N5O3/c26-25(27,28)18-1-2-21(33-11-9-32(10-12-33)15-19-14-30-16-35-19)20(13-18)31-24(34)23-4-3-22(36-23)17-5-7-29-8-6-17/h1-8,13-14,16H,9-12,15H2,(H,31,34)
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n/an/a 0.760n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448673
PNG
(N-(5-chloro-2-(4-(furan-2-ylmethyl)piperazin-1-yl)...)
Show SMILES Clc1ccc(N2CCN(Cc3ccco3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C25H23ClN4O3/c26-19-3-4-22(30-13-11-29(12-14-30)17-20-2-1-15-32-20)21(16-19)28-25(31)24-6-5-23(33-24)18-7-9-27-10-8-18/h1-10,15-16H,11-14,17H2,(H,28,31)
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n/an/a 1.20n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448662
PNG
(N-(2-(4-(oxazol-4-ylmethyl)piperazin-1-yl)-5- (tri...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cocn3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C25H22F3N5O3/c26-25(27,28)18-1-2-21(33-11-9-32(10-12-33)14-19-15-35-16-30-19)20(13-18)31-24(34)23-4-3-22(36-23)17-5-7-29-8-6-17/h1-8,13,15-16H,9-12,14H2,(H,31,34)
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n/an/a 1.30n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448675
PNG
(N-(2-(4-(furan-2-ylmethyl)piperazin-1-yl)-5- (trif...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccco3)CC2)c(NC(=O)c2ccccn2)c1
Show InChI InChI=1S/C22H21F3N4O2/c23-22(24,25)16-6-7-20(19(14-16)27-21(30)18-5-1-2-8-26-18)29-11-9-28(10-12-29)15-17-4-3-13-31-17/h1-8,13-14H,9-12,15H2,(H,27,30)
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n/an/a 1.40n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448664
PNG
(5-(tetrahydro-2H-pyran-4-yl)-N-(2-(4-(thiazol-4- y...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cscn3)CC2)c(NC(=O)c2ccc(o2)C2CCOCC2)c1
Show InChI InChI=1S/C25H27F3N4O3S/c26-25(27,28)18-1-2-21(32-9-7-31(8-10-32)14-19-15-36-16-29-19)20(13-18)30-24(33)23-4-3-22(35-23)17-5-11-34-12-6-17/h1-4,13,15-17H,5-12,14H2,(H,30,33)
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n/an/a 1.70n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448697
PNG
(N-(2-(4-(furan-3-ylmethyl)piperazin-1-yl)-5- (trif...)
Show SMILES Cc1ccc(o1)C(=O)Nc1cc(ccc1N1CCN(Cc2ccoc2)CC1)C(F)(F)F
Show InChI InChI=1S/C22H22F3N3O3/c1-15-2-5-20(31-15)21(29)26-18-12-17(22(23,24)25)3-4-19(18)28-9-7-27(8-10-28)13-16-6-11-30-14-16/h2-6,11-12,14H,7-10,13H2,1H3,(H,26,29)
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n/an/a 1.80n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448726
PNG
(N-(2-(4-(isoxazol-5-ylmethyl)piperazin-1-yl)-5-(tr...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccno3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C25H22F3N5O3/c26-25(27,28)18-1-2-21(33-13-11-32(12-14-33)16-19-7-10-30-36-19)20(15-18)31-24(34)23-4-3-22(35-23)17-5-8-29-9-6-17/h1-10,15H,11-14,16H2,(H,31,34)
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n/an/a 1.80n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448715
PNG
(N-(2-(4-(isoxazol-5-ylmethyl)piperazin-1-yl)-5-(tr...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccno3)CC2)c(NC(=O)c2ccccn2)c1
Show InChI InChI=1S/C21H20F3N5O2/c22-21(23,24)15-4-5-19(18(13-15)27-20(30)17-3-1-2-7-25-17)29-11-9-28(10-12-29)14-16-6-8-26-31-16/h1-8,13H,9-12,14H2,(H,27,30)
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Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448647
PNG
(N-(2-(4-((1H-pyrazol-3-yl)methyl)piperazin-1-yl)-5...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cc[nH]n3)CC2)c(NC(=O)c2ccc(o2)C2CCOCC2)c1
Show InChI InChI=1S/C25H28F3N5O3/c26-25(27,28)18-1-2-21(33-11-9-32(10-12-33)16-19-5-8-29-31-19)20(15-18)30-24(34)23-4-3-22(36-23)17-6-13-35-14-7-17/h1-5,8,15,17H,6-7,9-14,16H2,(H,29,31)(H,30,34)
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n/an/a 3.5n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448696
PNG
(N-(2-(4-((5-methylfuran-2-yl)methyl)piperazin-1-yl...)
Show SMILES Cc1ccc(CN2CCN(CC2)c2ccc(cc2NC(=O)c2ccc(o2)C2CCOCC2)C(F)(F)F)o1
Show InChI InChI=1S/C27H30F3N3O4/c1-18-2-4-21(36-18)17-32-10-12-33(13-11-32)23-5-3-20(27(28,29)30)16-22(23)31-26(34)25-7-6-24(37-25)19-8-14-35-15-9-19/h2-7,16,19H,8-15,17H2,1H3,(H,31,34)
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n/an/a 3.70n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448661
PNG
(N-(2-(4-(oxazol-2-ylmethyl)piperazin-1-yl)-5- (tri...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ncco3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C25H22F3N5O3/c26-25(27,28)18-1-2-20(33-12-10-32(11-13-33)16-23-30-9-14-35-23)19(15-18)31-24(34)22-4-3-21(36-22)17-5-7-29-8-6-17/h1-9,14-15H,10-13,16H2,(H,31,34)
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n/an/a 4.60n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448729
PNG
(N-(2-(4-(furan-3-ylmethyl)piperazin-1-yl)-5- (trif...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccoc3)CC2)c(NC(=O)c2ccccn2)c1
Show InChI InChI=1S/C22H21F3N4O2/c23-22(24,25)17-4-5-20(19(13-17)27-21(30)18-3-1-2-7-26-18)29-10-8-28(9-11-29)14-16-6-12-31-15-16/h1-7,12-13,15H,8-11,14H2,(H,27,30)
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n/an/a 5.30n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448717
PNG
(N-(2-(4-(isoxazol-5-ylmethyl)piperazin-1-yl)-5-(tr...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccno3)CC2)c(NC(=O)c2ccc(o2)C2CCOCC2)c1
Show InChI InChI=1S/C25H27F3N4O4/c26-25(27,28)18-1-2-21(32-11-9-31(10-12-32)16-19-5-8-29-36-19)20(15-18)30-24(33)23-4-3-22(35-23)17-6-13-34-14-7-17/h1-5,8,15,17H,6-7,9-14,16H2,(H,30,33)
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n/an/a 5.5n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448682
PNG
(N-(2-(4-(thiazol-4-ylmethyl)piperazin-1-yl)-5- (tr...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cscn3)CC2)c(NC(=O)c2ccccn2)c1
Show InChI InChI=1S/C21H20F3N5OS/c22-21(23,24)15-4-5-19(18(11-15)27-20(30)17-3-1-2-6-25-17)29-9-7-28(8-10-29)12-16-13-31-14-26-16/h1-6,11,13-14H,7-10,12H2,(H,27,30)
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n/an/a 6.70n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448674
PNG
(N-(5-chloro-2-(4-(oxazol-4-ylmethyl)piperazin-1-yl...)
Show SMILES Clc1ccc(N2CCN(Cc3cocn3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C24H22ClN5O3/c25-18-1-2-21(30-11-9-29(10-12-30)14-19-15-32-16-27-19)20(13-18)28-24(31)23-4-3-22(33-23)17-5-7-26-8-6-17/h1-8,13,15-16H,9-12,14H2,(H,28,31)
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n/an/a 8.20n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448723
PNG
(N-(2-(4-(isoxazol-4-ylmethyl)piperazin-1-yl)-5-(tr...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cnoc3)CC2)c(NC(=O)c2ccccn2)c1
Show InChI InChI=1S/C21H20F3N5O2/c22-21(23,24)16-4-5-19(18(11-16)27-20(30)17-3-1-2-6-25-17)29-9-7-28(8-10-29)13-15-12-26-31-14-15/h1-6,11-12,14H,7-10,13H2,(H,27,30)
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n/an/a 8.80n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448718
PNG
(US10696661, Compound 65)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cnoc3)CC2)c(NC(=O)c2ccc(o2)C2CCOCC2)c1
Show InChI InChI=1S/C25H27F3N4O4/c26-25(27,28)19-1-2-21(32-9-7-31(8-10-32)15-17-14-29-35-16-17)20(13-19)30-24(33)23-4-3-22(36-23)18-5-11-34-12-6-18/h1-4,13-14,16,18H,5-12,15H2,(H,30,33)
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n/an/a 9.70n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448698
PNG
(5-methyl-N-(2-(4-((5-methylfuran-2-yl)methyl)piper...)
Show SMILES Cc1ccc(CN2CCN(CC2)c2ccc(cc2NC(=O)c2ccc(C)o2)C(F)(F)F)o1
Show InChI InChI=1S/C23H24F3N3O3/c1-15-3-6-18(31-15)14-28-9-11-29(12-10-28)20-7-5-17(23(24,25)26)13-19(20)27-22(30)21-8-4-16(2)32-21/h3-8,13H,9-12,14H2,1-2H3,(H,27,30)
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n/an/a 10.7n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448670
PNG
(N-(2-(4-((1H-pyrazol-3-yl)methyl)piperazin-1-yl)-5...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cc[nH]n3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C25H23F3N6O2/c26-25(27,28)18-1-2-21(34-13-11-33(12-14-34)16-19-7-10-30-32-19)20(15-18)31-24(35)23-4-3-22(36-23)17-5-8-29-9-6-17/h1-10,15H,11-14,16H2,(H,30,32)(H,31,35)
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n/an/a 10.9n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448672
PNG
(N-(2-(4-((1-methyl-1H-pyrazol-3-yl)methyl)piperazi...)
Show SMILES Cn1ccc(CN2CCN(CC2)c2ccc(cc2NC(=O)c2ccc(o2)-c2ccncc2)C(F)(F)F)n1
Show InChI InChI=1S/C26H25F3N6O2/c1-33-11-8-20(32-33)17-34-12-14-35(15-13-34)22-3-2-19(26(27,28)29)16-21(22)31-25(36)24-5-4-23(37-24)18-6-9-30-10-7-18/h2-11,16H,12-15,17H2,1H3,(H,31,36)
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n/an/a 11.3n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448684
PNG
(N-(2-(4-((1H-pyrazol-3-yl)methyl)piperazin-1-yl)-5...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cc[nH]n3)CC2)c(NC(=O)c2ccccn2)c1
Show InChI InChI=1S/C21H21F3N6O/c22-21(23,24)15-4-5-19(18(13-15)27-20(31)17-3-1-2-7-25-17)30-11-9-29(10-12-30)14-16-6-8-26-28-16/h1-8,13H,9-12,14H2,(H,26,28)(H,27,31)
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n/an/a 12.7n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448667
PNG
(5-(pyridin-4-yl)-N-(2-(4-(thiazol-4-ylmethyl)piper...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cscn3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C25H22F3N5O2S/c26-25(27,28)18-1-2-21(33-11-9-32(10-12-33)14-19-15-36-16-30-19)20(13-18)31-24(34)23-4-3-22(35-23)17-5-7-29-8-6-17/h1-8,13,15-16H,9-12,14H2,(H,31,34)
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n/an/a 13.7n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448681
PNG
(N-(2-(4-(thiazol-2-ylmethyl)piperazin-1-yl)-5- (tr...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3nccs3)CC2)c(NC(=O)c2ccccn2)c1
Show InChI InChI=1S/C21H20F3N5OS/c22-21(23,24)15-4-5-18(17(13-15)27-20(30)16-3-1-2-6-25-16)29-10-8-28(9-11-29)14-19-26-7-12-31-19/h1-7,12-13H,8-11,14H2,(H,27,30)
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n/an/a 14.1n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448548
PNG
(5-methyl-N-(2-(4-((furan-2-yl)methyl)piperazin-1-y...)
Show SMILES Cc1ccc(o1)C(=O)Nc1cc(ccc1N1CCN(Cc2ccco2)CC1)C(F)(F)F
Show InChI InChI=1S/C22H22F3N3O3/c1-15-4-7-20(31-15)21(29)26-18-13-16(22(23,24)25)5-6-19(18)28-10-8-27(9-11-28)14-17-3-2-12-30-17/h2-7,12-13H,8-11,14H2,1H3,(H,26,29)
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n/an/a 17.6n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448704
PNG
(N-(2-(4-(oxazol-4-ylmethyl)piperazin-1-yl)-5-(trif...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cocn3)CC2)c(NC(=O)c2cc3ccccc3o2)c1
Show InChI InChI=1S/C24H21F3N4O3/c25-24(26,27)17-5-6-20(31-9-7-30(8-10-31)13-18-14-33-15-28-18)19(12-17)29-23(32)22-11-16-3-1-2-4-21(16)34-22/h1-6,11-12,14-15H,7-10,13H2,(H,29,32)
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n/an/a 21n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448657
PNG
(N-(2-(4-((5-methylfuran-2-yl)methyl)piperazin-1-yl...)
Show SMILES Cc1ccc(CN2CCN(CC2)c2ccc(cc2NC(=O)c2ccc(o2)-c2ccncc2)C(F)(F)F)o1
Show InChI InChI=1S/C27H25F3N4O3/c1-18-2-4-21(36-18)17-33-12-14-34(15-13-33)23-5-3-20(27(28,29)30)16-22(23)32-26(35)25-7-6-24(37-25)19-8-10-31-11-9-19/h2-11,16H,12-15,17H2,1H3,(H,32,35)
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n/an/a 21.4n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448687
PNG
(N-(2-(4-(oxazol-4-ylmethyl)piperazin-1-yl)-5- (tri...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cocn3)CC2)c(NC(=O)c2ccccn2)c1
Show InChI InChI=1S/C21H20F3N5O2/c22-21(23,24)15-4-5-19(18(11-15)27-20(30)17-3-1-2-6-25-17)29-9-7-28(8-10-29)12-16-13-31-14-26-16/h1-6,11,13-14H,7-10,12H2,(H,27,30)
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n/an/a 21.6n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448699
PNG
(N-(2-(4-(furan-3-ylmethyl)piperazin-1-yl)-5- (trif...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccoc3)CC2)c(NC(=O)c2ccco2)c1
Show InChI InChI=1S/C21H20F3N3O3/c22-21(23,24)16-3-4-18(17(12-16)25-20(28)19-2-1-10-30-19)27-8-6-26(7-9-27)13-15-5-11-29-14-15/h1-5,10-12,14H,6-9,13H2,(H,25,28)
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n/an/a 21.9n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448685
PNG
(N-(2-(4-((1-methyl-1H-pyrazol-3-yl)methyl)piperazi...)
Show SMILES Cn1ccc(CN2CCN(CC2)c2ccc(cc2NC(=O)c2ccccn2)C(F)(F)F)n1
Show InChI InChI=1S/C22H23F3N6O/c1-29-9-7-17(28-29)15-30-10-12-31(13-11-30)20-6-5-16(22(23,24)25)14-19(20)27-21(32)18-4-2-3-8-26-18/h2-9,14H,10-13,15H2,1H3,(H,27,32)
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n/an/a 27n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448680
PNG
(N-(5-chloro-2-(4-(furan-2-ylmethyl)piperazin-1- yl...)
Show SMILES Clc1ccc(N2CCN(Cc3ccco3)CC2)c(NC(=O)c2ccccn2)c1
Show InChI InChI=1S/C21H21ClN4O2/c22-16-6-7-20(19(14-16)24-21(27)18-5-1-2-8-23-18)26-11-9-25(10-12-26)15-17-4-3-13-28-17/h1-8,13-14H,9-12,15H2,(H,24,27)
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n/an/a 27.3n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448668
PNG
(5-(pyridin-4-yl)-N-(2-(5-(thiazol-2-ylmethyl)piper...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cncs3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C25H22F3N5O2S/c26-25(27,28)18-1-2-21(33-11-9-32(10-12-33)15-19-14-30-16-36-19)20(13-18)31-24(34)23-4-3-22(35-23)17-5-7-29-8-6-17/h1-8,13-14,16H,9-12,15H2,(H,31,34)
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n/an/a 27.5n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448693
PNG
(N-(2-(4-(1H-imidazol-4-ylmethyl)piperazin-1-yl)-5-...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3c[nH]cn3)CC2)c(NC(=O)c2ccccn2)c1
Show InChI InChI=1S/C21H21F3N6O/c22-21(23,24)15-4-5-19(18(11-15)28-20(31)17-3-1-2-6-26-17)30-9-7-29(8-10-30)13-16-12-25-14-27-16/h1-6,11-12,14H,7-10,13H2,(H,25,27)(H,28,31)
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n/an/a 28.7n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448693
PNG
(N-(2-(4-(1H-imidazol-4-ylmethyl)piperazin-1-yl)-5-...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3c[nH]cn3)CC2)c(NC(=O)c2ccccn2)c1
Show InChI InChI=1S/C21H21F3N6O/c22-21(23,24)15-4-5-19(18(11-15)28-20(31)17-3-1-2-6-26-17)30-9-7-29(8-10-30)13-16-12-25-14-27-16/h1-6,11-12,14H,7-10,13H2,(H,25,27)(H,28,31)
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n/an/a 28.7n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448690
PNG
(N-(2-(4-((1H-indol-3-yl)methyl)piperazin-1-yl)-5- ...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3c[nH]c4ccccc34)CC2)c(NC(=O)c2ccccn2)c1
Show InChI InChI=1S/C26H24F3N5O/c27-26(28,29)19-8-9-24(23(15-19)32-25(35)22-7-3-4-10-30-22)34-13-11-33(12-14-34)17-18-16-31-21-6-2-1-5-20(18)21/h1-10,15-16,31H,11-14,17H2,(H,32,35)
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n/an/a 31.3n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448700
PNG
(N-(2-(4-((5-methylfuran-2-yl)methyl)piperazin-1-yl...)
Show SMILES Cc1ccc(CN2CCN(CC2)c2ccc(cc2NC(=O)c2ccco2)C(F)(F)F)o1
Show InChI InChI=1S/C22H22F3N3O3/c1-15-4-6-17(31-15)14-27-8-10-28(11-9-27)19-7-5-16(22(23,24)25)13-18(19)26-21(29)20-3-2-12-30-20/h2-7,12-13H,8-11,14H2,1H3,(H,26,29)
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n/an/a 32.6n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448722
PNG
(N-(2-(4-(isoxazol-4-ylmethyl)piperazin-1-yl)-5-(tr...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cnoc3)CC2)c(NC(=O)c2ccco2)c1
Show InChI InChI=1S/C20H19F3N4O3/c21-20(22,23)15-3-4-17(16(10-15)25-19(28)18-2-1-9-29-18)27-7-5-26(6-8-27)12-14-11-24-30-13-14/h1-4,9-11,13H,5-8,12H2,(H,25,28)
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n/an/a 33.5n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448725
PNG
(N-(2-(4-(isoxazol-4-ylmethyl)piperazin-1-yl)-5- (t...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cnoc3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C25H22F3N5O3/c26-25(27,28)19-1-2-21(33-11-9-32(10-12-33)15-17-14-30-35-16-17)20(13-19)31-24(34)23-4-3-22(36-23)18-5-7-29-8-6-18/h1-8,13-14,16H,9-12,15H2,(H,31,34)
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n/an/a 35.3n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448621
PNG
(N-(2-(4-(thiazol-5-ylmethyl)piperazin-1-yl)-5- (tr...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cncs3)CC2)c(NC(=O)c2ccco2)c1
Show InChI InChI=1S/C20H19F3N4O2S/c21-20(22,23)14-3-4-17(16(10-14)25-19(28)18-2-1-9-29-18)27-7-5-26(6-8-27)12-15-11-24-13-30-15/h1-4,9-11,13H,5-8,12H2,(H,25,28)
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n/an/a 39.5n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448691
PNG
(US10696661, Compound 39)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cocn3)CC2)c(NC(=O)c2ccco2)c1
Show InChI InChI=1S/C20H19F3N4O3/c21-20(22,23)14-3-4-17(16(10-14)25-19(28)18-2-1-9-30-18)27-7-5-26(6-8-27)11-15-12-29-13-24-15/h1-4,9-10,12-13H,5-8,11H2,(H,25,28)
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n/an/a 60.7n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448574
PNG
(N-(2-(4-((1H-pyrazol-3-yl)methyl)piperazin-1-yl)-5...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cc[nH]n3)CC2)c(NC(=O)c2ccco2)c1
Show InChI InChI=1S/C20H20F3N5O2/c21-20(22,23)14-3-4-17(16(12-14)25-19(29)18-2-1-11-30-18)28-9-7-27(8-10-28)13-15-5-6-24-26-15/h1-6,11-12H,7-10,13H2,(H,24,26)(H,25,29)
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n/an/a 62.4n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448733
PNG
(N-(2-(4-((1H-indol-3-yl)methyl)piperazin-1-yl)-5- ...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3c[nH]c4ccccc34)CC2)c(NC(=O)c2ccco2)c1
Show InChI InChI=1S/C25H23F3N4O2/c26-25(27,28)18-7-8-22(21(14-18)30-24(33)23-6-3-13-34-23)32-11-9-31(10-12-32)16-17-15-29-20-5-2-1-4-19(17)20/h1-8,13-15,29H,9-12,16H2,(H,30,33)
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n/an/a 74.9n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448714
PNG
(N-(2-(4-((1H-pyrazol-4-yl)methyl)piperazin-1-yl)-5...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cn[nH]c3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C25H23F3N6O2/c26-25(27,28)19-1-2-21(34-11-9-33(10-12-34)16-17-14-30-31-15-17)20(13-19)32-24(35)23-4-3-22(36-23)18-5-7-29-8-6-18/h1-8,13-15H,9-12,16H2,(H,30,31)(H,32,35)
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n/an/a 75.9n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448592
PNG
(N-(2-(4-(thiazol-4-ylmethyl)piperazin-1-yl)-5- (tr...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cscn3)CC2)c(NC(=O)c2ccco2)c1
Show InChI InChI=1S/C20H19F3N4O2S/c21-20(22,23)14-3-4-17(16(10-14)25-19(28)18-2-1-9-29-18)27-7-5-26(6-8-27)11-15-12-30-13-24-15/h1-4,9-10,12-13H,5-8,11H2,(H,25,28)
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n/an/a 79.8n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448706
PNG
(N-(2-(4-(oxazol-4-ylmethyl)piperazin-1-yl)-5-(trif...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cocn3)CC2)c(NC(=O)c2cc[nH]n2)c1
Show InChI InChI=1S/C19H19F3N6O2/c20-19(21,22)13-1-2-17(16(9-13)25-18(29)15-3-4-24-26-15)28-7-5-27(6-8-28)10-14-11-30-12-23-14/h1-4,9,11-12H,5-8,10H2,(H,24,26)(H,25,29)
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n/an/a 83.1n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448545
PNG
(N-(2-(4-((5-methyl-1,3,4-oxadiazol-2-yl)methyl)pip...)
Show SMILES Cc1nnc(CN2CCN(CC2)c2ccc(cc2NC(=O)c2ccc(o2)-c2ccncc2)C(F)(F)F)o1
Show InChI InChI=1S/C25H23F3N6O3/c1-16-31-32-23(36-16)15-33-10-12-34(13-11-33)20-3-2-18(25(26,27)28)14-19(20)30-24(35)22-5-4-21(37-22)17-6-8-29-9-7-17/h2-9,14H,10-13,15H2,1H3,(H,30,35)
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n/an/a 88.3n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448711
PNG
(N-(2-(4-(oxazol-4-ylmethyl)piperazin-1-yl)-5-(trif...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cocn3)CC2)c(NC(=O)c2cccc(n2)C2CCOCC2)c1
Show InChI InChI=1S/C26H28F3N5O3/c27-26(28,29)19-4-5-24(34-10-8-33(9-11-34)15-20-16-37-17-30-20)23(14-19)32-25(35)22-3-1-2-21(31-22)18-6-12-36-13-7-18/h1-5,14,16-18H,6-13,15H2,(H,32,35)
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n/an/a 104n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448665
PNG
(US10696661, Compound 20)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3nccs3)CC2)c(NC(=O)c2ccco2)c1
Show InChI InChI=1S/C20H19F3N4O2S/c21-20(22,23)14-3-4-16(15(12-14)25-19(28)17-2-1-10-29-17)27-8-6-26(7-9-27)13-18-24-5-11-30-18/h1-5,10-12H,6-9,13H2,(H,25,28)
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n/an/a 104n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448701
PNG
(N-(2-(4-((5-methyl-1,3,4-oxadiazol-2-yl)methyl)pip...)
Show SMILES Cc1nnc(CN2CCN(CC2)c2ccc(cc2NC(=O)c2ccco2)C(F)(F)F)o1
Show InChI InChI=1S/C20H20F3N5O3/c1-13-25-26-18(31-13)12-27-6-8-28(9-7-27)16-5-4-14(20(21,22)23)11-15(16)24-19(29)17-3-2-10-30-17/h2-5,10-11H,6-9,12H2,1H3,(H,24,29)
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n/an/a 117n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448710
PNG
(N-(2-(4-(oxazol-4-ylmethyl)piperazin-1-yl)-5-(trif...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cocn3)CC2)c(NC(=O)c2cocn2)c1
Show InChI InChI=1S/C19H18F3N5O3/c20-19(21,22)13-1-2-17(15(7-13)25-18(28)16-10-30-12-24-16)27-5-3-26(4-6-27)8-14-9-29-11-23-14/h1-2,7,9-12H,3-6,8H2,(H,25,28)
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n/an/a 117n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448709
PNG
(N-(2-(4-(oxazol-4-ylmethyl)piperazin-1-yl)-5-(trif...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cocn3)CC2)c(NC(=O)c2ccncn2)c1
Show InChI InChI=1S/C20H19F3N6O2/c21-20(22,23)14-1-2-18(17(9-14)27-19(30)16-3-4-24-12-25-16)29-7-5-28(6-8-29)10-15-11-31-13-26-15/h1-4,9,11-13H,5-8,10H2,(H,27,30)
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n/an/a 134n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448692
PNG
(N-(2-(4-((5-methylfuran-2-yl)methyl)piperazin-1-yl...)
Show SMILES Cc1ccc(CN2CCN(CC2)c2ccc(cc2NC(=O)c2ccccn2)C(F)(F)F)o1
Show InChI InChI=1S/C23H23F3N4O2/c1-16-5-7-18(32-16)15-29-10-12-30(13-11-29)21-8-6-17(23(24,25)26)14-20(21)28-22(31)19-4-2-3-9-27-19/h2-9,14H,10-13,15H2,1H3,(H,28,31)
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n/an/a 145n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448596
PNG
(N-(2-(4-((1H-imidazol-4-yl)methyl)piperazin-1-yl)-...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3c[nH]cn3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C25H23F3N6O2/c26-25(27,28)18-1-2-21(34-11-9-33(10-12-34)15-19-14-30-16-31-19)20(13-18)32-24(35)23-4-3-22(36-23)17-5-7-29-8-6-17/h1-8,13-14,16H,9-12,15H2,(H,30,31)(H,32,35)
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n/an/a 158n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448705
PNG
(N-(2-(4-(oxazol-4-ylmethyl)piperazin-1-yl)-5-(trif...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cocn3)CC2)c(NC(=O)c2cnccn2)c1
Show InChI InChI=1S/C20H19F3N6O2/c21-20(22,23)14-1-2-18(16(9-14)27-19(30)17-10-24-3-4-25-17)29-7-5-28(6-8-29)11-15-12-31-13-26-15/h1-4,9-10,12-13H,5-8,11H2,(H,27,30)
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n/an/a 162n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM101829
PNG
(US10696661, Compound 74 | US9695160, 42 | US979670...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3c[nH]c4ccccc34)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C30H26F3N5O2/c31-30(32,33)22-5-6-26(25(17-22)36-29(39)28-8-7-27(40-28)20-9-11-34-12-10-20)38-15-13-37(14-16-38)19-21-18-35-24-4-2-1-3-23(21)24/h1-12,17-18,35H,13-16,19H2,(H,36,39)
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n/an/a 164n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448666
PNG
(5-(pyridin-4-yl)-N-(2-(4-(thiazol-2-ylmethyl)piper...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3nccs3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C25H22F3N5O2S/c26-25(27,28)18-1-2-20(33-12-10-32(11-13-33)16-23-30-9-14-36-23)19(15-18)31-24(34)22-4-3-21(35-22)17-5-7-29-8-6-17/h1-9,14-15H,10-13,16H2,(H,31,34)
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n/an/a 176n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448580
PNG
(N-(2-(4-((1-methyl-1H-pyrazol-3-yl)methyl)piperazi...)
Show SMILES Cn1ccc(CN2CCN(CC2)c2ccc(cc2NC(=O)c2ccco2)C(F)(F)F)n1
Show InChI InChI=1S/C21H22F3N5O2/c1-27-7-6-16(26-27)14-28-8-10-29(11-9-28)18-5-4-15(21(22,23)24)13-17(18)25-20(30)19-3-2-12-31-19/h2-7,12-13H,8-11,14H2,1H3,(H,25,30)
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n/an/a 191n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448713
PNG
(N-(2-(4-(furan-3-ylmethyl)piperazin-1-yl)-5-(trifl...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccoc3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C26H23F3N4O3/c27-26(28,29)20-1-2-22(33-12-10-32(11-13-33)16-18-7-14-35-17-18)21(15-20)31-25(34)24-4-3-23(36-24)19-5-8-30-9-6-19/h1-9,14-15,17H,10-13,16H2,(H,31,34)
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Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448716
PNG
(N-(2-(4-(isoxazol-5-ylmethyl)piperazin-1-yl)-5-(tr...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccno3)CC2)c(NC(=O)c2ccco2)c1
Show InChI InChI=1S/C20H19F3N4O3/c21-20(22,23)14-3-4-17(16(12-14)25-19(28)18-2-1-11-29-18)27-9-7-26(8-10-27)13-15-5-6-24-30-15/h1-6,11-12H,7-10,13H2,(H,25,28)
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antibodypedia
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n/an/a 317n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448546
PNG
(N-(2-(4-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)pi...)
Show SMILES Cc1ccc(o1)C(=O)Nc1cc(ccc1N1CCN(Cc2cn(Cc3ccccc3)nn2)CC1)C(F)(F)F
Show InChI InChI=1S/C27H27F3N6O2/c1-19-7-10-25(38-19)26(37)31-23-15-21(27(28,29)30)8-9-24(23)35-13-11-34(12-14-35)17-22-18-36(33-32-22)16-20-5-3-2-4-6-20/h2-10,15,18H,11-14,16-17H2,1H3,(H,31,37)
PDB
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UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 337n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448707
PNG
(N-(2-(4-(oxazol-4-ylmethyl)piperazin-1-yl)-5-(trif...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cocn3)CC2)c(NC(=O)c2ncccn2)c1
Show InChI InChI=1S/C20H19F3N6O2/c21-20(22,23)14-2-3-17(16(10-14)27-19(30)18-24-4-1-5-25-18)29-8-6-28(7-9-29)11-15-12-31-13-26-15/h1-5,10,12-13H,6-9,11H2,(H,27,30)
PDB
MMDB

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UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 344n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448686
PNG
(N-(2-(4-(furan-2-ylmethyl)piperazin-1-yl)-5-(trifl...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccco3)CC2)c(NC(=O)c2ccncc2)c1
Show InChI InChI=1S/C22H21F3N4O2/c23-22(24,25)17-3-4-20(19(14-17)27-21(30)16-5-7-26-8-6-16)29-11-9-28(10-12-29)15-18-2-1-13-31-18/h1-8,13-14H,9-12,15H2,(H,27,30)
PDB
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UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 388n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448702
PNG
(N-(2-(4-(oxazol-4-ylmethyl)piperazin-1-yl)-5-(trif...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cocn3)CC2)c(NC(=O)c2ccno2)c1
Show InChI InChI=1S/C19H18F3N5O3/c20-19(21,22)13-1-2-16(15(9-13)25-18(28)17-3-4-24-30-17)27-7-5-26(6-8-27)10-14-11-29-12-23-14/h1-4,9,11-12H,5-8,10H2,(H,25,28)
PDB
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UniProtKB/SwissProt

B.MOAD
antibodypedia
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US Patent
n/an/a 561n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448728
PNG
(N-(2-(4-(oxazol-4-ylmethyl)piperazin-1-yl)-5- (tri...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cocn3)CC2)c(NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C22H21F3N4O2/c23-22(24,25)17-6-7-20(19(12-17)27-21(30)16-4-2-1-3-5-16)29-10-8-28(9-11-29)13-18-14-31-15-26-18/h1-7,12,14-15H,8-11,13H2,(H,27,30)
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antibodypedia
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n/an/a 718n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448712
PNG
(N-(2-(4-(oxazol-4-ylmethyl)piperazin-1-yl)-5-(trif...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cocn3)CC2)c(NC(=O)c2ccc(cn2)C2CCOCC2)c1
Show InChI InChI=1S/C26H28F3N5O3/c27-26(28,29)20-2-4-24(34-9-7-33(8-10-34)15-21-16-37-17-31-21)23(13-20)32-25(35)22-3-1-19(14-30-22)18-5-11-36-12-6-18/h1-4,13-14,16-18H,5-12,15H2,(H,32,35)
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n/an/a 974n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448694
PNG
(N-(2-(4-(oxazol-4-ylmethyl)piperazin-1-yl)-5-(trif...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cocn3)CC2)c(NC(=O)c2ncco2)c1
Show InChI InChI=1S/C19H18F3N5O3/c20-19(21,22)13-1-2-16(15(9-13)25-17(28)18-23-3-8-30-18)27-6-4-26(5-7-27)10-14-11-29-12-24-14/h1-3,8-9,11-12H,4-7,10H2,(H,25,28)
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n/an/a 1.26E+3n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM448708
PNG
(N-(2-(4-(oxazol-4-ylmethyl)piperazin-1-yl)-5-(trif...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cocn3)CC2)c(NC(=O)c2nc3ccccc3o2)c1
Show InChI InChI=1S/C23H20F3N5O3/c24-23(25,26)15-5-6-19(31-9-7-30(8-10-31)12-16-13-33-14-27-16)18(11-15)28-21(32)22-29-17-3-1-2-4-20(17)34-22/h1-6,11,13-14H,7-10,12H2,(H,28,32)
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n/an/a 1.84E+3n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%