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Patent code US10696672

Compile Data Set for Download or QSAR
Found 157 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448821
PNG
(US10696672, Compound 53)
Show SMILES Cc1cc(C)n(n1)-c1cccc(c1)C(=O)N[C@@H](CCN1CCC[C@@](F)(CCc2ccc3CCCNc3n2)C1)C(O)=O
Show InChI InChI=1S/C31H39FN6O3/c1-21-18-22(2)38(36-21)26-8-3-6-24(19-26)29(39)35-27(30(40)41)12-17-37-16-5-13-31(32,20-37)14-11-25-10-9-23-7-4-15-33-28(23)34-25/h3,6,8-10,18-19,27H,4-5,7,11-17,20H2,1-2H3,(H,33,34)(H,35,39)(H,40,41)/t27-,31+/m0/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448840
PNG
(US10696672, Compound 72)
Show SMILES CC(C)Cn1cc2c(cccc2n1)C(=O)N[C@@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)C(O)=O
Show InChI InChI=1S/C30H40N6O3/c1-20(2)17-36-19-25-24(6-3-7-26(25)34-36)29(37)33-27(30(38)39)13-16-35-15-12-21(18-35)8-10-23-11-9-22-5-4-14-31-28(22)32-23/h3,6-7,9,11,19-21,27H,4-5,8,10,12-18H2,1-2H3,(H,31,32)(H,33,37)(H,38,39)/t21-,27+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448847
PNG
(US10696672, Compound 79)
Show SMILES CC(C)(C)C(=O)N1CCC[C@H](C1)C(=O)N[C@@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)C(O)=O
Show InChI InChI=1S/C29H45N5O4/c1-29(2,3)28(38)34-15-5-7-22(19-34)26(35)32-24(27(36)37)13-17-33-16-12-20(18-33)8-10-23-11-9-21-6-4-14-30-25(21)31-23/h9,11,20,22,24H,4-8,10,12-19H2,1-3H3,(H,30,31)(H,32,35)(H,36,37)/t20-,22-,24+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448851
PNG
(US10696672, Compound 83)
Show SMILES OC(=O)[C@@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C31H36N4O3/c36-30(26-9-4-8-25(20-26)23-6-2-1-3-7-23)34-28(31(37)38)16-19-35-18-15-22(21-35)11-13-27-14-12-24-10-5-17-32-29(24)33-27/h1-4,6-9,12,14,20,22,28H,5,10-11,13,15-19,21H2,(H,32,33)(H,34,36)(H,37,38)/t22-,28-/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448867
PNG
(US10696672, Compound 99)
Show SMILES OC(=O)[C@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)[C@@H]1CCCN1Cc1cccnc1
Show InChI InChI=1S/C29H40N6O3/c36-28(26-6-3-15-35(26)20-22-4-1-13-30-18-22)33-25(29(37)38)12-17-34-16-11-21(19-34)7-9-24-10-8-23-5-2-14-31-27(23)32-24/h1,4,8,10,13,18,21,25-26H,2-3,5-7,9,11-12,14-17,19-20H2,(H,31,32)(H,33,36)(H,37,38)/t21-,25+,26+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448883
PNG
(US10696672, Compound 115)
Show SMILES OC(=O)[C@H](CCN1CC(C1)OCCc1ccc2CCCNc2n1)NC(=O)c1c(Cl)cccc1Cl
Show InChI InChI=1S/C24H28Cl2N4O4/c25-18-4-1-5-19(26)21(18)23(31)29-20(24(32)33)8-11-30-13-17(14-30)34-12-9-16-7-6-15-3-2-10-27-22(15)28-16/h1,4-7,17,20H,2-3,8-14H2,(H,27,28)(H,29,31)(H,32,33)/t20-/m0/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448760
PNG
((S)-2-(2-chloro-3-fluorobenzamido)-4- | US10696672...)
Show SMILES OC(=O)[C@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)c1cccc(F)c1Cl
Show InChI InChI=1S/C25H30ClFN4O3/c26-22-19(4-1-5-20(22)27)24(32)30-21(25(33)34)11-14-31-13-10-16(15-31)6-8-18-9-7-17-3-2-12-28-23(17)29-18/h1,4-5,7,9,16,21H,2-3,6,8,10-15H2,(H,28,29)(H,30,32)(H,33,34)/t16-,21+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448767
PNG
(US10696672, Compound 7c)
Show SMILES OC(=O)[C@@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)c1c(Cl)cc(cc1Cl)C#N
Show InChI InChI=1S/C26H29Cl2N5O3/c27-20-12-17(14-29)13-21(28)23(20)25(34)32-22(26(35)36)8-11-33-10-7-16(15-33)3-5-19-6-4-18-2-1-9-30-24(18)31-19/h4,6,12-13,16,22H,1-3,5,7-11,15H2,(H,30,31)(H,32,34)(H,35,36)/t16-,22-/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448771
PNG
((S)-4-((R)-3-(2-(5,6,7,8-tetrahydro-1,8- | US10696...)
Show SMILES OC(=O)[C@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C26H31F3N4O3/c27-26(28,29)20-5-1-3-19(15-20)24(34)32-22(25(35)36)11-14-33-13-10-17(16-33)6-8-21-9-7-18-4-2-12-30-23(18)31-21/h1,3,5,7,9,15,17,22H,2,4,6,8,10-14,16H2,(H,30,31)(H,32,34)(H,35,36)/t17-,22+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448777
PNG
((R)-2-(3-(3,5-dimethyl-1H-pyrazol-1- | US10696672,...)
Show SMILES Cc1cc(C)n(n1)-c1cccc(c1)C(=O)N[C@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)C(O)=O
Show InChI InChI=1S/C30H38N6O3/c1-20-17-21(2)36(34-20)26-7-3-5-24(18-26)29(37)33-27(30(38)39)13-16-35-15-12-22(19-35)8-10-25-11-9-23-6-4-14-31-28(23)32-25/h3,5,7,9,11,17-18,22,27H,4,6,8,10,12-16,19H2,1-2H3,(H,31,32)(H,33,37)(H,38,39)/t22-,27-/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448785
PNG
((R)-2-(3,5-dichloroisonicotinamido)-4- | US1069667...)
Show SMILES OC(=O)[C@@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)c1c(Cl)cncc1Cl
Show InChI InChI=1S/C24H29Cl2N5O3/c25-18-12-27-13-19(26)21(18)23(32)30-20(24(33)34)8-11-31-10-7-15(14-31)3-5-17-6-4-16-2-1-9-28-22(16)29-17/h4,6,12-13,15,20H,1-3,5,7-11,14H2,(H,28,29)(H,30,32)(H,33,34)/t15-,20-/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448799
PNG
((R)-2-(benzo[d]oxazole-5- | US10696672, Compound 3...)
Show SMILES OC(=O)[C@@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)c1ccc2ocnc2c1
Show InChI InChI=1S/C26H31N5O4/c32-25(19-5-8-23-22(14-19)28-16-35-23)30-21(26(33)34)10-13-31-12-9-17(15-31)3-6-20-7-4-18-2-1-11-27-24(18)29-20/h4-5,7-8,14,16-17,21H,1-3,6,9-13,15H2,(H,27,29)(H,30,32)(H,33,34)/t17-,21-/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448815
PNG
(US10696672, Compound 47)
Show SMILES OC(=O)[C@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)[C@@H]1CCN(C1)c1ccccn1
Show InChI InChI=1S/C28H38N6O3/c35-27(22-11-17-34(19-22)25-5-1-2-13-29-25)32-24(28(36)37)12-16-33-15-10-20(18-33)6-8-23-9-7-21-4-3-14-30-26(21)31-23/h1-2,5,7,9,13,20,22,24H,3-4,6,8,10-12,14-19H2,(H,30,31)(H,32,35)(H,36,37)/t20-,22-,24+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448825
PNG
(US10696672, Compound 57)
Show SMILES Cn1nccc1-c1cccc(c1)C(=O)N[C@@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)C(O)=O
Show InChI InChI=1S/C29H36N6O3/c1-34-26(11-15-31-34)22-4-2-5-23(18-22)28(36)33-25(29(37)38)13-17-35-16-12-20(19-35)7-9-24-10-8-21-6-3-14-30-27(21)32-24/h2,4-5,8,10-11,15,18,20,25H,3,6-7,9,12-14,16-17,19H2,1H3,(H,30,32)(H,33,36)(H,37,38)/t20-,25+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448836
PNG
(US10696672, Compound 68)
Show SMILES CC(C)(C)c1cccc(c1)C(=O)N[C@@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)C(O)=O
Show InChI InChI=1S/C29H40N4O3/c1-29(2,3)23-8-4-6-22(18-23)27(34)32-25(28(35)36)14-17-33-16-13-20(19-33)9-11-24-12-10-21-7-5-15-30-26(21)31-24/h4,6,8,10,12,18,20,25H,5,7,9,11,13-17,19H2,1-3H3,(H,30,31)(H,32,34)(H,35,36)/t20-,25+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448796
PNG
((S)-2-(1-(difluoromethyl)-1H-indazole- | US1069667...)
Show SMILES OC(=O)[C@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)c1ccc2cnn(C(F)F)c2c1
Show InChI InChI=1S/C27H32F2N6O3/c28-27(29)35-23-14-19(4-5-20(23)15-31-35)25(36)33-22(26(37)38)10-13-34-12-9-17(16-34)3-7-21-8-6-18-2-1-11-30-24(18)32-21/h4-6,8,14-15,17,22,27H,1-3,7,9-13,16H2,(H,30,32)(H,33,36)(H,37,38)/t17-,22+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448802
PNG
(US10696672, Compound 35)
Show SMILES OC(=O)[C@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)c1cccc2[nH]ncc12
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448838
PNG
(US10696672, Compound 70)
Show SMILES OC(=O)[C@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)c1ccncn1
Show InChI InChI=1S/C23H30N6O3/c30-22(19-7-11-24-15-26-19)28-20(23(31)32)9-13-29-12-8-16(14-29)3-5-18-6-4-17-2-1-10-25-21(17)27-18/h4,6-7,11,15-16,20H,1-3,5,8-10,12-14H2,(H,25,27)(H,28,30)(H,31,32)/t16-,20+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448846
PNG
(US10696672, Compound 78)
Show SMILES CCCCC(=O)N1CCC[C@H](C1)C(=O)N[C@@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)C(O)=O
Show InChI InChI=1S/C29H45N5O4/c1-2-3-8-26(35)34-16-5-7-23(20-34)28(36)32-25(29(37)38)14-18-33-17-13-21(19-33)9-11-24-12-10-22-6-4-15-30-27(22)31-24/h10,12,21,23,25H,2-9,11,13-20H2,1H3,(H,30,31)(H,32,36)(H,37,38)/t21-,23-,25+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448858
PNG
(US10696672, Compound 90)
Show SMILES OC(=O)[C@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)[C@@H]1CCCN1Cc1ncccn1
Show InChI InChI=1S/C28H39N7O3/c36-27(24-5-2-15-35(24)19-25-29-13-3-14-30-25)33-23(28(37)38)11-17-34-16-10-20(18-34)6-8-22-9-7-21-4-1-12-31-26(21)32-22/h3,7,9,13-14,20,23-24H,1-2,4-6,8,10-12,15-19H2,(H,31,32)(H,33,36)(H,37,38)/t20-,23+,24+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448860
PNG
(US10696672, Compound 92)
Show SMILES OC(=O)[C@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)[C@@H]1CCCN1CC1CCC1
Show InChI InChI=1S/C28H43N5O3/c34-27(25-7-3-15-33(25)19-20-4-1-5-20)31-24(28(35)36)13-17-32-16-12-21(18-32)8-10-23-11-9-22-6-2-14-29-26(22)30-23/h9,11,20-21,24-25H,1-8,10,12-19H2,(H,29,30)(H,31,34)(H,35,36)/t21-,24+,25+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448891
PNG
(US10696672, Compound 123)
Show SMILES OC(=O)[C@H](CCN1CC(C1)OCCc1ccc2CCCNc2n1)NC(=O)[C@@H]1CCCN1Cc1ccccc1
Show InChI InChI=1S/C29H39N5O4/c35-28(26-9-5-15-34(26)18-21-6-2-1-3-7-21)32-25(29(36)37)12-16-33-19-24(20-33)38-17-13-23-11-10-22-8-4-14-30-27(22)31-23/h1-3,6-7,10-11,24-26H,4-5,8-9,12-20H2,(H,30,31)(H,32,35)(H,36,37)/t25-,26-/m0/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448895
PNG
(US10696672, Compound 127)
Show SMILES OC(=O)[C@H](CCN1CC(C1)OCCc1ccc2CCCNc2n1)NC(=O)[C@@H]1CCCN1c1ccccc1
Show InChI InChI=1S/C28H37N5O4/c34-27(25-9-5-15-33(25)22-7-2-1-3-8-22)31-24(28(35)36)12-16-32-18-23(19-32)37-17-13-21-11-10-20-6-4-14-29-26(20)30-21/h1-3,7-8,10-11,23-25H,4-6,9,12-19H2,(H,29,30)(H,31,34)(H,35,36)/t24-,25-/m0/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448908
PNG
(US10696672, Compound 140 | US10696672, Compound 14...)
Show SMILES OC(=O)[C@H](CCN1C2CCC1C(CCc1ccc3CCCNc3n1)C2)NC(=O)c1cc(F)cc(c1)C(F)(F)F
Show InChI InChI=1S/C28H32F4N4O3/c29-20-13-18(12-19(15-20)28(30,31)32)26(37)35-23(27(38)39)9-11-36-22-7-8-24(36)17(14-22)4-6-21-5-3-16-2-1-10-33-25(16)34-21/h3,5,12-13,15,17,22-24H,1-2,4,6-11,14H2,(H,33,34)(H,35,37)(H,38,39)/t17?,22?,23-,24?/m0/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448745
PNG
((S)-2-benzamido-4-((R)-3-(2-(5,6,7,8- | US10696672...)
Show SMILES OC(=O)[C@@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)c1ccccc1
Show InChI InChI=1S/C25H32N4O3/c30-24(20-5-2-1-3-6-20)28-22(25(31)32)13-16-29-15-12-18(17-29)8-10-21-11-9-19-7-4-14-26-23(19)27-21/h1-3,5-6,9,11,18,22H,4,7-8,10,12-17H2,(H,26,27)(H,28,30)(H,31,32)/t18-,22-/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448761
PNG
((S)-2-(2,6-dichlorobenzamido)-4-((R)- | US10696672...)
Show SMILES OC(=O)[C@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)c1c(Cl)cccc1Cl
Show InChI InChI=1S/C25H30Cl2N4O3/c26-19-4-1-5-20(27)22(19)24(32)30-21(25(33)34)11-14-31-13-10-16(15-31)6-8-18-9-7-17-3-2-12-28-23(17)29-18/h1,4-5,7,9,16,21H,2-3,6,8,10-15H2,(H,28,29)(H,30,32)(H,33,34)/t16-,21+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448812
PNG
(US10696672, Compound 44)
Show SMILES CC(C)(C(=O)N[C@@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)C(O)=O)c1ccccc1
Show InChI InChI=1S/C28H38N4O3/c1-28(2,22-8-4-3-5-9-22)27(35)31-24(26(33)34)15-18-32-17-14-20(19-32)10-12-23-13-11-21-7-6-16-29-25(21)30-23/h3-5,8-9,11,13,20,24H,6-7,10,12,14-19H2,1-2H3,(H,29,30)(H,31,35)(H,33,34)/t20-,24+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448826
PNG
(US10696672, Compound 58)
Show SMILES Cn1cc(cn1)-c1cccc(c1)C(=O)N[C@@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)C(O)=O
Show InChI InChI=1S/C29H36N6O3/c1-34-19-24(17-31-34)22-4-2-5-23(16-22)28(36)33-26(29(37)38)12-15-35-14-11-20(18-35)7-9-25-10-8-21-6-3-13-30-27(21)32-25/h2,4-5,8,10,16-17,19-20,26H,3,6-7,9,11-15,18H2,1H3,(H,30,32)(H,33,36)(H,37,38)/t20-,26+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448834
PNG
(US10696672, Compound 66)
Show SMILES OC(=O)[C@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)c1cccc(c1)-c1cncs1
Show InChI InChI=1S/C28H33N5O3S/c34-27(22-4-1-3-21(15-22)25-16-29-18-37-25)32-24(28(35)36)11-14-33-13-10-19(17-33)6-8-23-9-7-20-5-2-12-30-26(20)31-23/h1,3-4,7,9,15-16,18-19,24H,2,5-6,8,10-14,17H2,(H,30,31)(H,32,34)(H,35,36)/t19-,24+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448850
PNG
(US10696672, Compound 82)
Show SMILES Cn1nc(-c2ccccc2)c2cccc(C(=O)N[C@@H](CCN3CC[C@@H](CCc4ccc5CCCNc5n4)C3)C(O)=O)c12
Show InChI InChI=1S/C33H38N6O3/c1-38-30-26(29(37-38)23-7-3-2-4-8-23)10-5-11-27(30)32(40)36-28(33(41)42)17-20-39-19-16-22(21-39)12-14-25-15-13-24-9-6-18-34-31(24)35-25/h2-5,7-8,10-11,13,15,22,28H,6,9,12,14,16-21H2,1H3,(H,34,35)(H,36,40)(H,41,42)/t22-,28+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448853
PNG
(US10696672, Compound 85)
Show SMILES OC(=O)[C@@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)c1cccc(c1)-c1cscn1
Show InChI InChI=1S/C28H33N5O3S/c34-27(22-4-1-3-21(15-22)25-17-37-18-30-25)32-24(28(35)36)11-14-33-13-10-19(16-33)6-8-23-9-7-20-5-2-12-29-26(20)31-23/h1,3-4,7,9,15,17-19,24H,2,5-6,8,10-14,16H2,(H,29,31)(H,32,34)(H,35,36)/t19-,24-/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448745
PNG
((S)-2-benzamido-4-((R)-3-(2-(5,6,7,8- | US10696672...)
Show SMILES OC(=O)[C@@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)c1ccccc1
Show InChI InChI=1S/C25H32N4O3/c30-24(20-5-2-1-3-6-20)28-22(25(31)32)13-16-29-15-12-18(17-29)8-10-21-11-9-19-7-4-14-26-23(19)27-21/h1-3,5-6,9,11,18,22H,4,7-8,10,12-17H2,(H,26,27)(H,28,30)(H,31,32)/t18-,22-/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448772
PNG
((S)-4-((R)-3-(2-(5,6,7,8-tetrahydro-1,8- | US10696...)
Show SMILES OC(=O)[C@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C26H31F3N4O3/c27-26(28,29)20-7-4-19(5-8-20)24(34)32-22(25(35)36)12-15-33-14-11-17(16-33)3-9-21-10-6-18-2-1-13-30-23(18)31-21/h4-8,10,17,22H,1-3,9,11-16H2,(H,30,31)(H,32,34)(H,35,36)/t17-,22+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448776
PNG
((S)-2-(3-(3,5-dimethyl-1H-pyrazol-1- | US10696672,...)
Show SMILES Cc1cc(C)n(n1)-c1cccc(c1)C(=O)NC(CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)C(O)=O
Show InChI InChI=1S/C30H38N6O3/c1-20-17-21(2)36(34-20)26-7-3-5-24(18-26)29(37)33-27(30(38)39)13-16-35-15-12-22(19-35)8-10-25-11-9-23-6-4-14-31-28(23)32-25/h3,5,7,9,11,17-18,22,27H,4,6,8,10,12-16,19H2,1-2H3,(H,31,32)(H,33,37)(H,38,39)/t22-,27?/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448776
PNG
((S)-2-(3-(3,5-dimethyl-1H-pyrazol-1- | US10696672,...)
Show SMILES Cc1cc(C)n(n1)-c1cccc(c1)C(=O)NC(CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)C(O)=O
Show InChI InChI=1S/C30H38N6O3/c1-20-17-21(2)36(34-20)26-7-3-5-24(18-26)29(37)33-27(30(38)39)13-16-35-15-12-22(19-35)8-10-25-11-9-23-6-4-14-31-28(23)32-25/h3,5,7,9,11,17-18,22,27H,4,6,8,10,12-16,19H2,1-2H3,(H,31,32)(H,33,37)(H,38,39)/t22-,27?/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448779
PNG
((S)-2-(3-morpholinobenzamido)-4- | US10696672, Com...)
Show SMILES OC(=O)[C@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)c1cccc(c1)N1CCOCC1
Show InChI InChI=1S/C29H39N5O4/c35-28(23-3-1-5-25(19-23)34-15-17-38-18-16-34)32-26(29(36)37)11-14-33-13-10-21(20-33)6-8-24-9-7-22-4-2-12-30-27(22)31-24/h1,3,5,7,9,19,21,26H,2,4,6,8,10-18,20H2,(H,30,31)(H,32,35)(H,36,37)/t21-,26+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448782
PNG
((S)-2-(isonicotinamido)-4-((R)-3-(2- | US10696672,...)
Show SMILES OC(=O)[C@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)c1ccncc1
Show InChI InChI=1S/C24H31N5O3/c30-23(19-7-12-25-13-8-19)28-21(24(31)32)10-15-29-14-9-17(16-29)3-5-20-6-4-18-2-1-11-26-22(18)27-20/h4,6-8,12-13,17,21H,1-3,5,9-11,14-16H2,(H,26,27)(H,28,30)(H,31,32)/t17-,21+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448795
PNG
((S)-2-(1-methyl-1H-indazole-7- | US10696672, Compo...)
Show SMILES Cn1ncc2cccc(C(=O)N[C@@H](CCN3CC[C@@H](CCc4ccc5CCCNc5n4)C3)C(O)=O)c12
Show InChI InChI=1S/C27H34N6O3/c1-32-24-20(16-29-32)4-2-6-22(24)26(34)31-23(27(35)36)12-15-33-14-11-18(17-33)7-9-21-10-8-19-5-3-13-28-25(19)30-21/h2,4,6,8,10,16,18,23H,3,5,7,9,11-15,17H2,1H3,(H,28,30)(H,31,34)(H,35,36)/t18-,23+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448804
PNG
(US10696672, Compound 36)
Show SMILES OC(=O)[C@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)[C@@H]1CCCN1Cc1ccccc1
Show InChI InChI=1S/C30H41N5O3/c36-29(27-9-5-17-35(27)21-22-6-2-1-3-7-22)33-26(30(37)38)15-19-34-18-14-23(20-34)10-12-25-13-11-24-8-4-16-31-28(24)32-25/h1-3,6-7,11,13,23,26-27H,4-5,8-10,12,14-21H2,(H,31,32)(H,33,36)(H,37,38)/t23-,26+,27+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448814
PNG
(US10696672, Compound 46)
Show SMILES OC(=O)[C@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)[C@H]1CCN(C1)c1ccccn1
Show InChI InChI=1S/C28H38N6O3/c35-27(22-11-17-34(19-22)25-5-1-2-13-29-25)32-24(28(36)37)12-16-33-15-10-20(18-33)6-8-23-9-7-21-4-3-14-30-26(21)31-23/h1-2,5,7,9,13,20,22,24H,3-4,6,8,10-12,14-19H2,(H,30,31)(H,32,35)(H,36,37)/t20-,22+,24+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448816
PNG
(US10696672, Compound 48)
Show SMILES OC(=O)[C@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)c1cccc(c1)C#N
Show InChI InChI=1S/C26H31N5O3/c27-16-19-3-1-4-21(15-19)25(32)30-23(26(33)34)11-14-31-13-10-18(17-31)6-8-22-9-7-20-5-2-12-28-24(20)29-22/h1,3-4,7,9,15,18,23H,2,5-6,8,10-14,17H2,(H,28,29)(H,30,32)(H,33,34)/t18-,23+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448819
PNG
(US10696672, Compound 51)
Show SMILES OC(=O)[C@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)c1cccs1
Show InChI InChI=1S/C23H30N4O3S/c28-22(20-4-2-14-31-20)26-19(23(29)30)10-13-27-12-9-16(15-27)5-7-18-8-6-17-3-1-11-24-21(17)25-18/h2,4,6,8,14,16,19H,1,3,5,7,9-13,15H2,(H,24,25)(H,26,28)(H,29,30)/t16-,19+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448822
PNG
(US10696672, Compound 54)
Show SMILES OC(=O)[C@H](CCN1CCCC(CCc2ccc3CCCNc3n2)C1)NC(=O)c1ccccc1
Show InChI InChI=1S/C26H34N4O3/c31-25(21-7-2-1-3-8-21)29-23(26(32)33)14-17-30-16-5-6-19(18-30)10-12-22-13-11-20-9-4-15-27-24(20)28-22/h1-3,7-8,11,13,19,23H,4-6,9-10,12,14-18H2,(H,27,28)(H,29,31)(H,32,33)/t19?,23-/m0/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448844
PNG
(US10696672, Compound 76)
Show SMILES OC(=O)[C@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)c1cc(F)cc(c1)C(F)(F)F
Show InChI InChI=1S/C26H30F4N4O3/c27-20-13-18(12-19(14-20)26(28,29)30)24(35)33-22(25(36)37)8-11-34-10-7-16(15-34)3-5-21-6-4-17-2-1-9-31-23(17)32-21/h4,6,12-14,16,22H,1-3,5,7-11,15H2,(H,31,32)(H,33,35)(H,36,37)/t16-,22+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448852
PNG
(US10696672, Compound 84)
Show SMILES OC(=O)[C@@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)c1cccc(c1)-c1cncs1
Show InChI InChI=1S/C28H33N5O3S/c34-27(22-4-1-3-21(15-22)25-16-29-18-37-25)32-24(28(35)36)11-14-33-13-10-19(17-33)6-8-23-9-7-20-5-2-12-30-26(20)31-23/h1,3-4,7,9,15-16,18-19,24H,2,5-6,8,10-14,17H2,(H,30,31)(H,32,34)(H,35,36)/t19-,24-/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448855
PNG
(US10696672, Compound 87)
Show SMILES Cn1cc(cn1)-c1cccc(c1)C(=O)N[C@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)C(O)=O
Show InChI InChI=1S/C29H36N6O3/c1-34-19-24(17-31-34)22-4-2-5-23(16-22)28(36)33-26(29(37)38)12-15-35-14-11-20(18-35)7-9-25-10-8-21-6-3-13-30-27(21)32-25/h2,4-5,8,10,16-17,19-20,26H,3,6-7,9,11-15,18H2,1H3,(H,30,32)(H,33,36)(H,37,38)/t20-,26-/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448871
PNG
(US10696672, Compound 103)
Show SMILES OC(=O)[C@H](CCN1CCC[C@](F)(CCc2ccc3CCCNc3n2)C1)NC(=O)c1cccc(F)c1Cl
Show InChI InChI=1S/C26H31ClF2N4O3/c27-22-19(5-1-6-20(22)28)24(34)32-21(25(35)36)10-15-33-14-3-11-26(29,16-33)12-9-18-8-7-17-4-2-13-30-23(17)31-18/h1,5-8,21H,2-4,9-16H2,(H,30,31)(H,32,34)(H,35,36)/t21-,26-/m0/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448736
PNG
((R)-2-pivalamido-4-((R)-3-(2-(5,6,7,8- | US1069667...)
Show SMILES CC(C)(C)C(=O)N[C@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)C(O)=O
Show InChI InChI=1S/C23H36N4O3/c1-23(2,3)22(30)26-19(21(28)29)11-14-27-13-10-16(15-27)6-8-18-9-7-17-5-4-12-24-20(17)25-18/h7,9,16,19H,4-6,8,10-15H2,1-3H3,(H,24,25)(H,26,30)(H,28,29)/t16-,19-/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448766
PNG
(US10696672, Compound 7a)
Show SMILES OC(=O)[C@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)c1c(Cl)cc(cc1Cl)C#N
Show InChI InChI=1S/C26H29Cl2N5O3/c27-20-12-17(14-29)13-21(28)23(20)25(34)32-22(26(35)36)8-11-33-10-7-16(15-33)3-5-19-6-4-18-2-1-9-30-24(18)31-19/h4,6,12-13,16,22H,1-3,5,7-11,15H2,(H,30,31)(H,32,34)(H,35,36)/t16-,22+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448774
PNG
((S)-2-(2,6-dichlorobenzamido)-4-((R)- | US10696672...)
Show SMILES OC(=O)[C@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)c1cc(OC(F)(F)F)ccc1Cl
Show InChI InChI=1S/C26H30ClF3N4O4/c27-21-8-7-19(38-26(28,29)30)14-20(21)24(35)33-22(25(36)37)10-13-34-12-9-16(15-34)3-5-18-6-4-17-2-1-11-31-23(17)32-18/h4,6-8,14,16,22H,1-3,5,9-13,15H2,(H,31,32)(H,33,35)(H,36,37)/t16-,22+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448787
PNG
((R)-2-(4,4-difluorocyclohexane-1- | US10696672, Co...)
Show SMILES OC(=O)[C@@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)C1CCC(F)(F)CC1
Show InChI InChI=1S/C25H36F2N4O3/c26-25(27)11-7-19(8-12-25)23(32)30-21(24(33)34)10-15-31-14-9-17(16-31)3-5-20-6-4-18-2-1-13-28-22(18)29-20/h4,6,17,19,21H,1-3,5,7-16H2,(H,28,29)(H,30,32)(H,33,34)/t17-,21-/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448797
PNG
((S)-2-(1-(difluoromethyl)-1H-indazole- | US1069667...)
Show SMILES OC(=O)[C@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)c1ccc2n(ncc2c1)C(F)F
Show InChI InChI=1S/C27H32F2N6O3/c28-27(29)35-23-8-5-19(14-20(23)15-31-35)25(36)33-22(26(37)38)10-13-34-12-9-17(16-34)3-6-21-7-4-18-2-1-11-30-24(18)32-21/h4-5,7-8,14-15,17,22,27H,1-3,6,9-13,16H2,(H,30,32)(H,33,36)(H,37,38)/t17-,22+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448811
PNG
(US10696672, Compound 43)
Show SMILES OC(=O)[C@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)[C@@H]1CCCN1c1ccccc1
Show InChI InChI=1S/C29H39N5O3/c35-28(26-9-5-17-34(26)24-7-2-1-3-8-24)32-25(29(36)37)15-19-33-18-14-21(20-33)10-12-23-13-11-22-6-4-16-30-27(22)31-23/h1-3,7-8,11,13,21,25-26H,4-6,9-10,12,14-20H2,(H,30,31)(H,32,35)(H,36,37)/t21-,25+,26+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448818
PNG
(US10696672, Compound 50)
Show SMILES OC(=O)[C@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)c1cnccn1
Show InChI InChI=1S/C23H30N6O3/c30-22(20-14-24-10-11-25-20)28-19(23(31)32)8-13-29-12-7-16(15-29)3-5-18-6-4-17-2-1-9-26-21(17)27-18/h4,6,10-11,14,16,19H,1-3,5,7-9,12-13,15H2,(H,26,27)(H,28,30)(H,31,32)/t16-,19+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448823
PNG
(US10696672, Compound 55)
Show SMILES OC(=O)[C@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)c1cccc(c1)-c1cccs1
Show InChI InChI=1S/C29H34N4O3S/c34-28(23-5-1-4-22(18-23)26-7-3-17-37-26)32-25(29(35)36)13-16-33-15-12-20(19-33)8-10-24-11-9-21-6-2-14-30-27(21)31-24/h1,3-5,7,9,11,17-18,20,25H,2,6,8,10,12-16,19H2,(H,30,31)(H,32,34)(H,35,36)/t20-,25+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448824
PNG
(US10696672, Compound 56)
Show SMILES OC(=O)[C@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C31H36N4O3/c36-30(26-9-4-8-25(20-26)23-6-2-1-3-7-23)34-28(31(37)38)16-19-35-18-15-22(21-35)11-13-27-14-12-24-10-5-17-32-29(24)33-27/h1-4,6-9,12,14,20,22,28H,5,10-11,13,15-19,21H2,(H,32,33)(H,34,36)(H,37,38)/t22-,28+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448828
PNG
(US10696672, Compound 60)
Show SMILES CC(C)n1ncc2c(cccc12)C(=O)N[C@@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)C(O)=O
Show InChI InChI=1S/C29H38N6O3/c1-19(2)35-26-7-3-6-23(24(26)17-31-35)28(36)33-25(29(37)38)13-16-34-15-12-20(18-34)8-10-22-11-9-21-5-4-14-30-27(21)32-22/h3,6-7,9,11,17,19-20,25H,4-5,8,10,12-16,18H2,1-2H3,(H,30,32)(H,33,36)(H,37,38)/t20-,25+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448842
PNG
(US10696672, Compound 74)
Show SMILES OC(=O)[C@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)[C@@H]1CCCCN1C(=O)C1CCC1
Show InChI InChI=1S/C29H43N5O4/c35-27(25-8-1-2-16-34(25)28(36)22-5-3-6-22)32-24(29(37)38)14-18-33-17-13-20(19-33)9-11-23-12-10-21-7-4-15-30-26(21)31-23/h10,12,20,22,24-25H,1-9,11,13-19H2,(H,30,31)(H,32,35)(H,37,38)/t20-,24+,25+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448843
PNG
(US10696672, Compound 75)
Show SMILES OC(=O)[C@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)Cc1ccccc1Cl
Show InChI InChI=1S/C26H33ClN4O3/c27-22-6-2-1-4-20(22)16-24(32)30-23(26(33)34)12-15-31-14-11-18(17-31)7-9-21-10-8-19-5-3-13-28-25(19)29-21/h1-2,4,6,8,10,18,23H,3,5,7,9,11-17H2,(H,28,29)(H,30,32)(H,33,34)/t18-,23+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448848
PNG
(US10696672, Compound 80)
Show SMILES COC(=O)N1CCC[C@H](C1)C(=O)N[C@@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)C(O)=O
Show InChI InChI=1S/C26H39N5O5/c1-36-26(35)31-13-3-5-20(17-31)24(32)29-22(25(33)34)11-15-30-14-10-18(16-30)6-8-21-9-7-19-4-2-12-27-23(19)28-21/h7,9,18,20,22H,2-6,8,10-17H2,1H3,(H,27,28)(H,29,32)(H,33,34)/t18-,20-,22+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448856
PNG
(US10696672, Compound 88)
Show SMILES OC(=O)[C@@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)c1cccc(c1)-c1ncco1
Show InChI InChI=1S/C28H33N5O4/c34-26(21-3-1-4-22(17-21)27-30-13-16-37-27)32-24(28(35)36)11-15-33-14-10-19(18-33)6-8-23-9-7-20-5-2-12-29-25(20)31-23/h1,3-4,7,9,13,16-17,19,24H,2,5-6,8,10-12,14-15,18H2,(H,29,31)(H,32,34)(H,35,36)/t19-,24-/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448872
PNG
(US10696672, Compound 104)
Show SMILES OC(=O)[C@H](CCN1CCC[C@](F)(CCc2ccc3CCCNc3n2)C1)NC(=O)c1cc(F)cc(F)c1
Show InChI InChI=1S/C26H31F3N4O3/c27-19-13-18(14-20(28)15-19)24(34)32-22(25(35)36)7-12-33-11-2-8-26(29,16-33)9-6-21-5-4-17-3-1-10-30-23(17)31-21/h4-5,13-15,22H,1-3,6-12,16H2,(H,30,31)(H,32,34)(H,35,36)/t22-,26-/m0/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448878
PNG
(US10696672, Compound 110)
Show SMILES Cn1ncc2ccc(cc12)C(=O)N[C@@H](CCN1CCC[C@](F)(CCc2ccc3CCCNc3n2)C1)C(O)=O
Show InChI InChI=1S/C28H35FN6O3/c1-34-24-16-20(5-6-21(24)17-31-34)26(36)33-23(27(37)38)10-15-35-14-3-11-28(29,18-35)12-9-22-8-7-19-4-2-13-30-25(19)32-22/h5-8,16-17,23H,2-4,9-15,18H2,1H3,(H,30,32)(H,33,36)(H,37,38)/t23-,28-/m0/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448757
PNG
((S)-2-(2,6-dimethylbenzamido)-4-((R)- | US10696672...)
Show SMILES Cc1cccc(C)c1C(=O)N[C@@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)C(O)=O
Show InChI InChI=1S/C27H36N4O3/c1-18-5-3-6-19(2)24(18)26(32)30-23(27(33)34)13-16-31-15-12-20(17-31)8-10-22-11-9-21-7-4-14-28-25(21)29-22/h3,5-6,9,11,20,23H,4,7-8,10,12-17H2,1-2H3,(H,28,29)(H,30,32)(H,33,34)/t20-,23+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448784
PNG
((S)-2-(3,5-dichloroisonicotinamido)-4- | US1069667...)
Show SMILES OC(=O)[C@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)c1c(Cl)cncc1Cl
Show InChI InChI=1S/C24H29Cl2N5O3/c25-18-12-27-13-19(26)21(18)23(32)30-20(24(33)34)8-11-31-10-7-15(14-31)3-5-17-6-4-16-2-1-9-28-22(16)29-17/h4,6,12-13,15,20H,1-3,5,7-11,14H2,(H,28,29)(H,30,32)(H,33,34)/t15-,20+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448786
PNG
((S)-2-(4,4-difluorocyclohexane-1- | US10696672, Co...)
Show SMILES OC(=O)[C@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)C1CCC(F)(F)CC1
Show InChI InChI=1S/C25H36F2N4O3/c26-25(27)11-7-19(8-12-25)23(32)30-21(24(33)34)10-15-31-14-9-17(16-31)3-5-20-6-4-18-2-1-13-28-22(18)29-20/h4,6,17,19,21H,1-3,5,7-16H2,(H,28,29)(H,30,32)(H,33,34)/t17-,21+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448817
PNG
(US10696672, Compound 49)
Show SMILES Cn1nccc1C(=O)N[C@@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)C(O)=O
Show InChI InChI=1S/C23H32N6O3/c1-28-20(8-12-25-28)22(30)27-19(23(31)32)10-14-29-13-9-16(15-29)4-6-18-7-5-17-3-2-11-24-21(17)26-18/h5,7-8,12,16,19H,2-4,6,9-11,13-15H2,1H3,(H,24,26)(H,27,30)(H,31,32)/t16-,19+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448827
PNG
(US10696672, Compound 59)
Show SMILES OC(=O)[C@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)c1cccc(c1)-c1ncco1
Show InChI InChI=1S/C28H33N5O4/c34-26(21-3-1-4-22(17-21)27-30-13-16-37-27)32-24(28(35)36)11-15-33-14-10-19(18-33)6-8-23-9-7-20-5-2-12-29-25(20)31-23/h1,3-4,7,9,13,16-17,19,24H,2,5-6,8,10-12,14-15,18H2,(H,29,31)(H,32,34)(H,35,36)/t19-,24+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448829
PNG
(US10696672, Compound 61)
Show SMILES CC(C)Cn1ncc2c(cccc12)C(=O)N[C@@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)C(O)=O
Show InChI InChI=1S/C30H40N6O3/c1-20(2)18-36-27-7-3-6-24(25(27)17-32-36)29(37)34-26(30(38)39)13-16-35-15-12-21(19-35)8-10-23-11-9-22-5-4-14-31-28(22)33-23/h3,6-7,9,11,17,20-21,26H,4-5,8,10,12-16,18-19H2,1-2H3,(H,31,33)(H,34,37)(H,38,39)/t21-,26+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448841
PNG
(US10696672, Compound 73)
Show SMILES CCCCC(=O)N1CCCC[C@H]1C(=O)N[C@@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)C(O)=O
Show InChI InChI=1S/C29H45N5O4/c1-2-3-9-26(35)34-17-5-4-8-25(34)28(36)32-24(29(37)38)15-19-33-18-14-21(20-33)10-12-23-13-11-22-7-6-16-30-27(22)31-23/h11,13,21,24-25H,2-10,12,14-20H2,1H3,(H,30,31)(H,32,36)(H,37,38)/t21-,24+,25+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448845
PNG
(US10696672, Compound 77)
Show SMILES CC(C)(O)CN1CCC[C@H]1C(=O)N[C@@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)C(O)=O
Show InChI InChI=1S/C27H43N5O4/c1-27(2,36)18-32-14-4-6-23(32)25(33)30-22(26(34)35)12-16-31-15-11-19(17-31)7-9-21-10-8-20-5-3-13-28-24(20)29-21/h8,10,19,22-23,36H,3-7,9,11-18H2,1-2H3,(H,28,29)(H,30,33)(H,34,35)/t19-,22+,23+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448857
PNG
(US10696672, Compound 89)
Show SMILES OC(=O)[C@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)[C@@H]1COCCN1Cc1ccccc1
Show InChI InChI=1S/C30H41N5O4/c36-29(27-21-39-18-17-35(27)20-22-5-2-1-3-6-22)33-26(30(37)38)13-16-34-15-12-23(19-34)8-10-25-11-9-24-7-4-14-31-28(24)32-25/h1-3,5-6,9,11,23,26-27H,4,7-8,10,12-21H2,(H,31,32)(H,33,36)(H,37,38)/t23-,26+,27+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448863
PNG
(US10696672, Compound 95)
Show SMILES CCC(CC)C(=O)N[C@@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)C(O)=O
Show InChI InChI=1S/C24H38N4O3/c1-3-18(4-2)23(29)27-21(24(30)31)12-15-28-14-11-17(16-28)7-9-20-10-8-19-6-5-13-25-22(19)26-20/h8,10,17-18,21H,3-7,9,11-16H2,1-2H3,(H,25,26)(H,27,29)(H,30,31)/t17-,21+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448743
PNG
((S)-2-((tert-butoxycarbonyl)amino)-4- | US10696672...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)C(O)=O
Show InChI InChI=1S/C23H36N4O4/c1-23(2,3)31-22(30)26-19(21(28)29)11-14-27-13-10-16(15-27)6-8-18-9-7-17-5-4-12-24-20(17)25-18/h7,9,16,19H,4-6,8,10-15H2,1-3H3,(H,24,25)(H,26,30)(H,28,29)/t16-,19+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448759
PNG
((R)-2-(2,6-dimethylbenzamido)-4-((R)- | US10696672...)
Show SMILES Cc1cccc(C)c1C(=O)N[C@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)C(O)=O
Show InChI InChI=1S/C27H36N4O3/c1-18-5-3-6-19(2)24(18)26(32)30-23(27(33)34)13-16-31-15-12-20(17-31)8-10-22-11-9-21-7-4-14-28-25(21)29-22/h3,5-6,9,11,20,23H,4,7-8,10,12-17H2,1-2H3,(H,28,29)(H,30,32)(H,33,34)/t20-,23-/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448793
PNG
((S)-2-(1H-indazole-7-carboxamido)-4- | US10696672,...)
Show SMILES OC(=O)[C@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)c1cccc2cn[nH]c12
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448798
PNG
((S)-2-(benzo[d]oxazole-5- | US10696672, Compound 3...)
Show SMILES OC(=O)[C@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)c1ccc2ocnc2c1
Show InChI InChI=1S/C26H31N5O4/c32-25(19-5-8-23-22(14-19)28-16-35-23)30-21(26(33)34)10-13-31-12-9-17(15-31)3-6-20-7-4-18-2-1-11-27-24(18)29-20/h4-5,7-8,14,16-17,21H,1-3,6,9-13,15H2,(H,27,29)(H,30,32)(H,33,34)/t17-,21+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448805
PNG
(US10696672, Compound 37)
Show SMILES CC(C)(C(=O)N[C@@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)C(O)=O)c1cccnc1
Show InChI InChI=1S/C27H37N5O3/c1-27(2,21-6-4-13-28-17-21)26(35)31-23(25(33)34)12-16-32-15-11-19(18-32)7-9-22-10-8-20-5-3-14-29-24(20)30-22/h4,6,8,10,13,17,19,23H,3,5,7,9,11-12,14-16,18H2,1-2H3,(H,29,30)(H,31,35)(H,33,34)/t19-,23+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448813
PNG
(US10696672, Compound 45)
Show SMILES CC(C)(Cc1ccccc1)C(=O)N[C@@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)C(O)=O
Show InChI InChI=1S/C29H40N4O3/c1-29(2,19-21-7-4-3-5-8-21)28(36)32-25(27(34)35)15-18-33-17-14-22(20-33)10-12-24-13-11-23-9-6-16-30-26(23)31-24/h3-5,7-8,11,13,22,25H,6,9-10,12,14-20H2,1-2H3,(H,30,31)(H,32,36)(H,34,35)/t22-,25+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448835
PNG
(US10696672, Compound 67)
Show SMILES OC(=O)[C@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)c1cccc(F)c1F
Show InChI InChI=1S/C25H30F2N4O3/c26-20-5-1-4-19(22(20)27)24(32)30-21(25(33)34)11-14-31-13-10-16(15-31)6-8-18-9-7-17-3-2-12-28-23(17)29-18/h1,4-5,7,9,16,21H,2-3,6,8,10-15H2,(H,28,29)(H,30,32)(H,33,34)/t16-,21+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448839
PNG
(US10696672, Compound 71)
Show SMILES CC(C)n1cc2c(cccc2n1)C(=O)N[C@@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)C(O)=O
Show InChI InChI=1S/C29H38N6O3/c1-19(2)35-18-24-23(6-3-7-25(24)33-35)28(36)32-26(29(37)38)13-16-34-15-12-20(17-34)8-10-22-11-9-21-5-4-14-30-27(21)31-22/h3,6-7,9,11,18-20,26H,4-5,8,10,12-17H2,1-2H3,(H,30,31)(H,32,36)(H,37,38)/t20-,26+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448854
PNG
(US10696672, Compound 86)
Show SMILES Cn1nccc1-c1cccc(c1)C(=O)N[C@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)C(O)=O
Show InChI InChI=1S/C29H36N6O3/c1-34-26(11-15-31-34)22-4-2-5-23(18-22)28(36)33-25(29(37)38)13-17-35-16-12-20(19-35)7-9-24-10-8-21-6-3-14-30-27(21)32-24/h2,4-5,8,10-11,15,18,20,25H,3,6-7,9,12-14,16-17,19H2,1H3,(H,30,32)(H,33,36)(H,37,38)/t20-,25-/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448914
PNG
(US10696672, Compound 146)
Show SMILES OC(=O)[C@H](CCN1CC[C@H](CCc2ccc3CCCNc3n2)C1)NC(=O)c1c(Cl)cccc1Cl
Show InChI InChI=1S/C25H30Cl2N4O3/c26-19-4-1-5-20(27)22(19)24(32)30-21(25(33)34)11-14-31-13-10-16(15-31)6-8-18-9-7-17-3-2-12-28-23(17)29-18/h1,4-5,7,9,16,21H,2-3,6,8,10-15H2,(H,28,29)(H,30,32)(H,33,34)/t16-,21-/m0/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448768
PNG
((S)-4-((R)-3-(2-(5,6,7,8-tetrahydro-1,8- | US10696...)
Show SMILES OC(=O)[C@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C26H31F3N4O3/c27-26(28,29)21-6-2-1-5-20(21)24(34)32-22(25(35)36)12-15-33-14-11-17(16-33)7-9-19-10-8-18-4-3-13-30-23(18)31-19/h1-2,5-6,8,10,17,22H,3-4,7,9,11-16H2,(H,30,31)(H,32,34)(H,35,36)/t17-,22+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448777
PNG
((R)-2-(3-(3,5-dimethyl-1H-pyrazol-1- | US10696672,...)
Show SMILES Cc1cc(C)n(n1)-c1cccc(c1)C(=O)N[C@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)C(O)=O
Show InChI InChI=1S/C30H38N6O3/c1-20-17-21(2)36(34-20)26-7-3-5-24(18-26)29(37)33-27(30(38)39)13-16-35-15-12-22(19-35)8-10-25-11-9-23-6-4-14-31-28(23)32-25/h3,5,7,9,11,17-18,22,27H,4,6,8,10,12-16,19H2,1-2H3,(H,31,32)(H,33,37)(H,38,39)/t22-,27-/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448791
PNG
((S)-2-(1-methyl-1H-indazole-6- | US10696672, Compo...)
Show SMILES Cn1ncc2ccc(cc12)C(=O)N[C@@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)C(O)=O
Show InChI InChI=1S/C27H34N6O3/c1-32-24-15-20(5-6-21(24)16-29-32)26(34)31-23(27(35)36)11-14-33-13-10-18(17-33)4-8-22-9-7-19-3-2-12-28-25(19)30-22/h5-7,9,15-16,18,23H,2-4,8,10-14,17H2,1H3,(H,28,30)(H,31,34)(H,35,36)/t18-,23+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448794
PNG
((S)-2-(1-methyl-1H-indazole-4- | US10696672, Compo...)
Show SMILES Cn1ncc2c(cccc12)C(=O)N[C@@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)C(O)=O
Show InChI InChI=1S/C27H34N6O3/c1-32-24-6-2-5-21(22(24)16-29-32)26(34)31-23(27(35)36)12-15-33-14-11-18(17-33)7-9-20-10-8-19-4-3-13-28-25(19)30-20/h2,5-6,8,10,16,18,23H,3-4,7,9,11-15,17H2,1H3,(H,28,30)(H,31,34)(H,35,36)/t18-,23+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448806
PNG
(US10696672, Compound 38)
Show SMILES OC(=O)[C@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)C1CCOCC1
Show InChI InChI=1S/C24H36N4O4/c29-23(19-9-14-32-15-10-19)27-21(24(30)31)8-13-28-12-7-17(16-28)3-5-20-6-4-18-2-1-11-25-22(18)26-20/h4,6,17,19,21H,1-3,5,7-16H2,(H,25,26)(H,27,29)(H,30,31)/t17-,21+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448837
PNG
(US10696672, Compound 69)
Show SMILES Cn1cc(cn1)C(=O)N[C@@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)C(O)=O
Show InChI InChI=1S/C23H32N6O3/c1-28-15-18(13-25-28)22(30)27-20(23(31)32)9-12-29-11-8-16(14-29)4-6-19-7-5-17-3-2-10-24-21(17)26-19/h5,7,13,15-16,20H,2-4,6,8-12,14H2,1H3,(H,24,26)(H,27,30)(H,31,32)/t16-,20+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448899
PNG
(US10696672, Compound 131)
Show SMILES OC(=O)[C@H](CCN1CC(C1)OCCc1ccc2CCCNc2n1)NC(=O)[C@@H]1CCN(C1)c1ccccn1
Show InChI InChI=1S/C27H36N6O4/c34-26(20-8-14-33(16-20)24-5-1-2-11-28-24)31-23(27(35)36)9-13-32-17-22(18-32)37-15-10-21-7-6-19-4-3-12-29-25(19)30-21/h1-2,5-7,11,20,22-23H,3-4,8-10,12-18H2,(H,29,30)(H,31,34)(H,35,36)/t20-,23+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448868
PNG
(US10696672, Compound 100)
Show SMILES COCCOc1cccc(c1)C(=O)N[C@@H](CCN1CCC[C@@](F)(CCc2ccc3CCCNc3n2)C1)C(O)=O
Show InChI InChI=1S/C29H39FN4O5/c1-38-17-18-39-24-7-2-5-22(19-24)27(35)33-25(28(36)37)11-16-34-15-4-12-29(30,20-34)13-10-23-9-8-21-6-3-14-31-26(21)32-23/h2,5,7-9,19,25H,3-4,6,10-18,20H2,1H3,(H,31,32)(H,33,35)(H,36,37)/t25-,29+/m0/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448778
PNG
((S)-2-(2-morpholinobenzamido)-4- | US10696672, Com...)
Show SMILES OC(=O)[C@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)c1ccccc1N1CCOCC1
Show InChI InChI=1S/C29H39N5O4/c35-28(24-5-1-2-6-26(24)34-16-18-38-19-17-34)32-25(29(36)37)12-15-33-14-11-21(20-33)7-9-23-10-8-22-4-3-13-30-27(22)31-23/h1-2,5-6,8,10,21,25H,3-4,7,9,11-20H2,(H,30,31)(H,32,35)(H,36,37)/t21-,25+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448783
PNG
((S)-2-(nicotinamido)-4-((R)-3-(2- | US10696672, Co...)
Show SMILES OC(=O)[C@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)c1cccnc1
Show InChI InChI=1S/C24H31N5O3/c30-23(19-4-1-11-25-15-19)28-21(24(31)32)10-14-29-13-9-17(16-29)5-7-20-8-6-18-3-2-12-26-22(18)27-20/h1,4,6,8,11,15,17,21H,2-3,5,7,9-10,12-14,16H2,(H,26,27)(H,28,30)(H,31,32)/t17-,21+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448788
PNG
((S)-2-(4-methyltetrahydro-2H-pyran-4- | US10696672...)
Show SMILES CC1(CCOCC1)C(=O)N[C@@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)C(O)=O
Show InChI InChI=1S/C25H38N4O4/c1-25(10-15-33-16-11-25)24(32)28-21(23(30)31)9-14-29-13-8-18(17-29)4-6-20-7-5-19-3-2-12-26-22(19)27-20/h5,7,18,21H,2-4,6,8-17H2,1H3,(H,26,27)(H,28,32)(H,30,31)/t18-,21+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448790
PNG
((R)-2-(1-cyclopropylpiperidine-4- | US10696672, Co...)
Show SMILES OC(=O)[C@@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)C1CCN(CC1)C1CC1
Show InChI InChI=1S/C27H41N5O3/c33-26(21-10-16-32(17-11-21)23-7-8-23)30-24(27(34)35)12-15-31-14-9-19(18-31)3-5-22-6-4-20-2-1-13-28-25(20)29-22/h4,6,19,21,23-24H,1-3,5,7-18H2,(H,28,29)(H,30,33)(H,34,35)/t19-,24-/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448809
PNG
(US10696672, Compound 41)
Show SMILES OC(=O)[C@H](CCN1CC(CCc2ccc3CCCNc3n2)CC(F)(F)C1)NC(=O)c1ccccc1
Show InChI InChI=1S/C26H32F2N4O3/c27-26(28)15-18(8-10-21-11-9-19-7-4-13-29-23(19)30-21)16-32(17-26)14-12-22(25(34)35)31-24(33)20-5-2-1-3-6-20/h1-3,5-6,9,11,18,22H,4,7-8,10,12-17H2,(H,29,30)(H,31,33)(H,34,35)/t18?,22-/m0/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448849
PNG
(US10696672, Compound 81)
Show SMILES OC(=O)[C@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)[C@@H]1CCN1Cc1ccccc1
Show InChI InChI=1S/C29H39N5O3/c35-28(26-14-18-34(26)20-21-5-2-1-3-6-21)32-25(29(36)37)13-17-33-16-12-22(19-33)8-10-24-11-9-23-7-4-15-30-27(23)31-24/h1-3,5-6,9,11,22,25-26H,4,7-8,10,12-20H2,(H,30,31)(H,32,35)(H,36,37)/t22-,25+,26+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448861
PNG
(US10696672, Compound 93)
Show SMILES OC(=O)[C@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)[C@@H]1CCCCN1Cc1ccccc1
Show InChI InChI=1S/C31H43N5O3/c37-30(28-10-4-5-18-36(28)22-23-7-2-1-3-8-23)34-27(31(38)39)16-20-35-19-15-24(21-35)11-13-26-14-12-25-9-6-17-32-29(25)33-26/h1-3,7-8,12,14,24,27-28H,4-6,9-11,13,15-22H2,(H,32,33)(H,34,37)(H,38,39)/t24-,27+,28+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448830
PNG
(US10696672, Compound 62)
Show SMILES OC(=O)[C@H](CCN1CCC[C@@](F)(CCc2ccc3CCCNc3n2)C1)NC(=O)c1cccc(F)c1Cl
Show InChI InChI=1S/C26H31ClF2N4O3/c27-22-19(5-1-6-20(22)28)24(34)32-21(25(35)36)10-15-33-14-3-11-26(29,16-33)12-9-18-8-7-17-4-2-13-30-23(17)31-18/h1,5-8,21H,2-4,9-16H2,(H,30,31)(H,32,34)(H,35,36)/t21-,26+/m0/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448874
PNG
(US10696672, Compound 106)
Show SMILES Cn1ncc2ccc(cc12)C(=O)N[C@@H](CCN1CCC[C@@](F)(CCc2ccc3CCCNc3n2)C1)C(O)=O
Show InChI InChI=1S/C28H35FN6O3/c1-34-24-16-20(5-6-21(24)17-31-34)26(36)33-23(27(37)38)10-15-35-14-3-11-28(29,18-35)12-9-22-8-7-19-4-2-13-30-25(19)32-22/h5-8,16-17,23H,2-4,9-15,18H2,1H3,(H,30,32)(H,33,36)(H,37,38)/t23-,28+/m0/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448877
PNG
(US10696672, Compound 109)
Show SMILES OC(=O)[C@H](CCN1CCC[C@](F)(CCc2ccc3CCCNc3n2)C1)NC(=O)C1CCC(F)(F)CC1
Show InChI InChI=1S/C26H37F3N4O3/c27-25(11-8-20-5-4-18-3-1-14-30-22(18)31-20)10-2-15-33(17-25)16-9-21(24(35)36)32-23(34)19-6-12-26(28,29)13-7-19/h4-5,19,21H,1-3,6-17H2,(H,30,31)(H,32,34)(H,35,36)/t21-,25-/m0/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448807
PNG
(US10696672, Compound 39)
Show SMILES OC(=O)[C@H](CCN1CC(CCc2ccc3CCCNc3n2)C(F)(F)C1)NC(=O)c1ccccc1
Show InChI InChI=1S/C25H30F2N4O3/c26-25(27)16-31(14-12-21(24(33)34)30-23(32)18-5-2-1-3-6-18)15-19(25)9-11-20-10-8-17-7-4-13-28-22(17)29-20/h1-3,5-6,8,10,19,21H,4,7,9,11-16H2,(H,28,29)(H,30,32)(H,33,34)/t19?,21-/m0/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448832
PNG
(US10696672, Compound 64)
Show SMILES OC(=O)[C@H](CCN1CC[C@](F)(CCc2ccc3CCCNc3n2)C1)NC(=O)c1c(Cl)cccc1Cl
Show InChI InChI=1S/C25H29Cl2FN4O3/c26-18-4-1-5-19(27)21(18)23(33)31-20(24(34)35)9-13-32-14-11-25(28,15-32)10-8-17-7-6-16-3-2-12-29-22(16)30-17/h1,4-7,20H,2-3,8-15H2,(H,29,30)(H,31,33)(H,34,35)/t20-,25+/m0/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448789
PNG
((S)-2-(1-cyclopropylpiperidine-4- | US10696672, Co...)
Show SMILES OC(=O)[C@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)C1CCN(CC1)C1CC1
Show InChI InChI=1S/C27H41N5O3/c33-26(21-10-16-32(17-11-21)23-7-8-23)30-24(27(34)35)12-15-31-14-9-19(18-31)3-5-22-6-4-20-2-1-13-28-25(20)29-22/h4,6,19,21,23-24H,1-3,5,7-18H2,(H,28,29)(H,30,33)(H,34,35)/t19-,24+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448862
PNG
(US10696672, Compound 94)
Show SMILES CCC(CC)C(=O)N[C@@H](CCN1CCC[C@@](F)(CCc2ccc3CCCNc3n2)C1)C(O)=O
Show InChI InChI=1S/C25H39FN4O3/c1-3-18(4-2)23(31)29-21(24(32)33)11-16-30-15-6-12-25(26,17-30)13-10-20-9-8-19-7-5-14-27-22(19)28-20/h8-9,18,21H,3-7,10-17H2,1-2H3,(H,27,28)(H,29,31)(H,32,33)/t21-,25+/m0/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448900
PNG
(US10696672, Compound 132)
Show SMILES OC(=O)[C@H](CCN1CC(C1)OCCc1ccc2CCCNc2n1)NC(=O)[C@H]1CCN(C1)c1ccccn1
Show InChI InChI=1S/C27H36N6O4/c34-26(20-8-14-33(16-20)24-5-1-2-11-28-24)31-23(27(35)36)9-13-32-17-22(18-32)37-15-10-21-7-6-19-4-3-12-29-25(19)30-21/h1-2,5-7,11,20,22-23H,3-4,8-10,12-18H2,(H,29,30)(H,31,34)(H,35,36)/t20-,23-/m0/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448792
PNG
((S)-2-(1-methyl-1H-indazole-5- | US10696672, Compo...)
Show SMILES Cn1ncc2cc(ccc12)C(=O)N[C@@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)C(O)=O
Show InChI InChI=1S/C27H34N6O3/c1-32-24-9-6-20(15-21(24)16-29-32)26(34)31-23(27(35)36)11-14-33-13-10-18(17-33)4-7-22-8-5-19-3-2-12-28-25(19)30-22/h5-6,8-9,15-16,18,23H,2-4,7,10-14,17H2,1H3,(H,28,30)(H,31,34)(H,35,36)/t18-,23+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448820
PNG
(US10696672, Compound 52)
Show SMILES OC(=O)[C@H](CCN1CCC[C@@](F)(CCc2ccc3CCCNc3n2)C1)NC(=O)c1ccccc1
Show InChI InChI=1S/C26H33FN4O3/c27-26(14-11-21-10-9-19-8-4-15-28-23(19)29-21)13-5-16-31(18-26)17-12-22(25(33)34)30-24(32)20-6-2-1-3-7-20/h1-3,6-7,9-10,22H,4-5,8,11-18H2,(H,28,29)(H,30,32)(H,33,34)/t22-,26+/m0/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448781
PNG
((S)-2-(picolinamido)-4-((R)-3-(2- | US10696672, Co...)
Show SMILES OC(=O)[C@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)c1ccccn1
Show InChI InChI=1S/C24H31N5O3/c30-23(20-5-1-2-12-25-20)28-21(24(31)32)11-15-29-14-10-17(16-29)6-8-19-9-7-18-4-3-13-26-22(18)27-19/h1-2,5,7,9,12,17,21H,3-4,6,8,10-11,13-16H2,(H,26,27)(H,28,30)(H,31,32)/t17-,21+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448888
PNG
(US10696672, Compound 120)
Show SMILES CC(C)(C(=O)N[C@@H](CCN1CC(C1)OCCc1ccc2CCCNc2n1)C(O)=O)c1ccccc1
Show InChI InChI=1S/C27H36N4O4/c1-27(2,20-8-4-3-5-9-20)26(34)30-23(25(32)33)12-15-31-17-22(18-31)35-16-13-21-11-10-19-7-6-14-28-24(19)29-21/h3-5,8-11,22-23H,6-7,12-18H2,1-2H3,(H,28,29)(H,30,34)(H,32,33)/t23-/m0/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448831
PNG
(US10696672, Compound 63)
Show SMILES OC(=O)[C@H](CCN1CC[C@@](F)(CCc2ccc3CCCNc3n2)C1)NC(=O)c1c(Cl)cccc1Cl
Show InChI InChI=1S/C25H29Cl2FN4O3/c26-18-4-1-5-19(27)21(18)23(33)31-20(24(34)35)9-13-32-14-11-25(28,15-32)10-8-17-7-6-16-3-2-12-29-22(16)30-17/h1,4-7,20H,2-3,8-15H2,(H,29,30)(H,31,33)(H,34,35)/t20-,25-/m0/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448833
PNG
(US10696672, Compound 65)
Show SMILES OC(=O)[C@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)c1cccc(c1)-c1cscn1
Show InChI InChI=1S/C28H33N5O3S/c34-27(22-4-1-3-21(15-22)25-17-37-18-30-25)32-24(28(35)36)11-14-33-13-10-19(16-33)6-8-23-9-7-20-5-2-12-29-26(20)31-23/h1,3-4,7,9,15,17-19,24H,2,5-6,8,10-14,16H2,(H,29,31)(H,32,34)(H,35,36)/t19-,24+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448864
PNG
(US10696672, Compound 96)
Show SMILES OC(=O)[C@H](CCN1CCC[C@@](F)(CCc2ccc3CCCNc3n2)C1)NC(=O)c1cccc(c1)N1CCOCC1
Show InChI InChI=1S/C30H40FN5O4/c31-30(12-9-24-8-7-22-5-2-13-32-27(22)33-24)11-3-14-35(21-30)15-10-26(29(38)39)34-28(37)23-4-1-6-25(20-23)36-16-18-40-19-17-36/h1,4,6-8,20,26H,2-3,5,9-19,21H2,(H,32,33)(H,34,37)(H,38,39)/t26-,30+/m0/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448865
PNG
(US10696672, Compound 97)
Show SMILES OC(=O)[C@H](CCN1CCC[C@@](F)(CCc2ccc3CCCNc3n2)C1)NC(=O)c1cc(F)cc(F)c1
Show InChI InChI=1S/C26H31F3N4O3/c27-19-13-18(14-20(28)15-19)24(34)32-22(25(35)36)7-12-33-11-2-8-26(29,16-33)9-6-21-5-4-17-3-1-10-30-23(17)31-21/h4-5,13-15,22H,1-3,6-12,16H2,(H,30,31)(H,32,34)(H,35,36)/t22-,26+/m0/s1
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n/an/a 150n/an/an/an/an/an/a



Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448873
PNG
(US10696672, Compound 105)
Show SMILES OC(=O)[C@H](CCN1CCC[C@@](F)(CCc2ccc3CCCNc3n2)C1)NC(=O)c1cc(F)cc(c1)C(F)(F)F
Show InChI InChI=1S/C27H31F5N4O3/c28-20-14-18(13-19(15-20)27(30,31)32)24(37)35-22(25(38)39)7-12-36-11-2-8-26(29,16-36)9-6-21-5-4-17-3-1-10-33-23(17)34-21/h4-5,13-15,22H,1-3,6-12,16H2,(H,33,34)(H,35,37)(H,38,39)/t22-,26+/m0/s1
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n/an/a 150n/an/an/an/an/an/a



Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448875
PNG
(US10696672, Compound 107)
Show SMILES OC(=O)[C@H](CCN1CCC[C@@](F)(CCc2ccc3CCCNc3n2)C1)NC(=O)C1CCC(F)(F)CC1
Show InChI InChI=1S/C26H37F3N4O3/c27-25(11-8-20-5-4-18-3-1-14-30-22(18)31-20)10-2-15-33(17-25)16-9-21(24(35)36)32-23(34)19-6-12-26(28,29)13-7-19/h4-5,19,21H,1-3,6-17H2,(H,30,31)(H,32,34)(H,35,36)/t21-,25+/m0/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448892
PNG
(US10696672, Compound 124)
Show SMILES OC(=O)[C@H](CCN1CC(C1)OCCc1ccc2CCCNc2n1)NC(=O)C1CCOCC1
Show InChI InChI=1S/C23H34N4O5/c28-22(17-6-11-31-12-7-17)26-20(23(29)30)5-10-27-14-19(15-27)32-13-8-18-4-3-16-2-1-9-24-21(16)25-18/h3-4,17,19-20H,1-2,5-15H2,(H,24,25)(H,26,28)(H,29,30)/t20-/m0/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448859
PNG
(US10696672, Compound 91)
Show SMILES OC(=O)[C@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)[C@@H]1CCCN1CC1CC1
Show InChI InChI=1S/C27H41N5O3/c33-26(24-4-2-14-32(24)18-19-5-6-19)30-23(27(34)35)12-16-31-15-11-20(17-31)7-9-22-10-8-21-3-1-13-28-25(21)29-22/h8,10,19-20,23-24H,1-7,9,11-18H2,(H,28,29)(H,30,33)(H,34,35)/t20-,23+,24+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448869
PNG
(US10696672, Compound 101)
Show SMILES OC(=O)[C@H](CCN1CCC[C@@](F)(CCc2ccc3CCCNc3n2)C1)NC(=O)c1c(Cl)cccc1Cl
Show InChI InChI=1S/C26H31Cl2FN4O3/c27-19-5-1-6-20(28)22(19)24(34)32-21(25(35)36)10-15-33-14-3-11-26(29,16-33)12-9-18-8-7-17-4-2-13-30-23(17)31-18/h1,5-8,21H,2-4,9-16H2,(H,30,31)(H,32,34)(H,35,36)/t21-,26+/m0/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448870
PNG
(US10696672, Compound 102)
Show SMILES Cn1cc(cn1)-c1nn(C)c2c(cccc12)C(=O)N[C@@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)C(O)=O
Show InChI InChI=1S/C31H38N8O3/c1-37-19-22(17-33-37)27-24-6-3-7-25(28(24)38(2)36-27)30(40)35-26(31(41)42)13-16-39-15-12-20(18-39)8-10-23-11-9-21-5-4-14-32-29(21)34-23/h3,6-7,9,11,17,19-20,26H,4-5,8,10,12-16,18H2,1-2H3,(H,32,34)(H,35,40)(H,41,42)/t20-,26+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448906
PNG
(US10696672, Compound 138)
Show SMILES OC(=O)[C@H](CCN1CC(CCc2ccc3CCCNc3n2)C1)NC(=O)[C@H]1CCN(C1)c1ccccn1
Show InChI InChI=1S/C27H36N6O3/c34-26(21-10-15-33(18-21)24-5-1-2-12-28-24)31-23(27(35)36)11-14-32-16-19(17-32)6-8-22-9-7-20-4-3-13-29-25(20)30-22/h1-2,5,7,9,12,19,21,23H,3-4,6,8,10-11,13-18H2,(H,29,30)(H,31,34)(H,35,36)/t21-,23-/m0/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448876
PNG
(US10696672, Compound 108)
Show SMILES CCC(CC)C(=O)N[C@@H](CCN1CCC[C@](F)(CCc2ccc3CCCNc3n2)C1)C(O)=O
Show InChI InChI=1S/C25H39FN4O3/c1-3-18(4-2)23(31)29-21(24(32)33)11-16-30-15-6-12-25(26,17-30)13-10-20-9-8-19-7-5-14-27-22(19)28-20/h8-9,18,21H,3-7,10-17H2,1-2H3,(H,27,28)(H,29,31)(H,32,33)/t21-,25-/m0/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448885
PNG
(US10696672, Compound 117)
Show SMILES OC(=O)[C@H](CCN1CC[C@H](C1)OCCc1ccc2CCCNc2n1)NC(=O)C1CCOCC1
Show InChI InChI=1S/C24H36N4O5/c29-23(18-7-13-32-14-8-18)27-21(24(30)31)6-12-28-11-5-20(16-28)33-15-9-19-4-3-17-2-1-10-25-22(17)26-19/h3-4,18,20-21H,1-2,5-16H2,(H,25,26)(H,27,29)(H,30,31)/t20-,21+/m1/s1
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n/an/a 625n/an/an/an/an/an/a



Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448886
PNG
(US10696672, Compound 118)
Show SMILES CC(C)(C(=O)N[C@@H](CCN1CC[C@H](C1)OCCc1ccc2CCCNc2n1)C(O)=O)c1ccccc1
Show InChI InChI=1S/C28H38N4O4/c1-28(2,21-8-4-3-5-9-21)27(35)31-24(26(33)34)13-17-32-16-12-23(19-32)36-18-14-22-11-10-20-7-6-15-29-25(20)30-22/h3-5,8-11,23-24H,6-7,12-19H2,1-2H3,(H,29,30)(H,31,35)(H,33,34)/t23-,24+/m1/s1
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n/an/a 625n/an/an/an/an/an/a



Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448890
PNG
(US10696672, Compound 122)
Show SMILES CC(C)(C(=O)N[C@@H](CCN1CC[C@H](C1)OCCc1ccc2CCCNc2n1)C(O)=O)c1cccnc1
Show InChI InChI=1S/C27H37N5O4/c1-27(2,20-6-4-12-28-17-20)26(35)31-23(25(33)34)10-15-32-14-9-22(18-32)36-16-11-21-8-7-19-5-3-13-29-24(19)30-21/h4,6-8,12,17,22-23H,3,5,9-11,13-16,18H2,1-2H3,(H,29,30)(H,31,35)(H,33,34)/t22-,23+/m1/s1
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n/an/a 625n/an/an/an/an/an/a



Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448897
PNG
(US10696672, Compound 129)
Show SMILES OC(=O)[C@H](CCN1CC(CCc2ccc3CCCNc3n2)C1)NC(=O)[C@@H]1CCCN1c1ccccc1
Show InChI InChI=1S/C28H37N5O3/c34-27(25-9-5-16-33(25)23-7-2-1-3-8-23)31-24(28(35)36)14-17-32-18-20(19-32)10-12-22-13-11-21-6-4-15-29-26(21)30-22/h1-3,7-8,11,13,20,24-25H,4-6,9-10,12,14-19H2,(H,29,30)(H,31,34)(H,35,36)/t24-,25-/m0/s1
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n/an/a 625n/an/an/an/an/an/a



Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448889
PNG
(US10696672, Compound 121)
Show SMILES OC(=O)[C@H](CCN1CC[C@H](C1)OCCc1ccc2CCCNc2n1)NC(=O)[C@@H]1CCCN1Cc1ccccc1
Show InChI InChI=1S/C30H41N5O4/c36-29(27-9-5-16-35(27)20-22-6-2-1-3-7-22)33-26(30(37)38)13-18-34-17-12-25(21-34)39-19-14-24-11-10-23-8-4-15-31-28(23)32-24/h1-3,6-7,10-11,25-27H,4-5,8-9,12-21H2,(H,31,32)(H,33,36)(H,37,38)/t25-,26+,27+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448893
PNG
(US10696672, Compound 125)
Show SMILES OC(=O)[C@H](CCN1CC[C@H](C1)OCCc1ccc2CCCNc2n1)NC(=O)[C@@H]1CCN(C1)c1ccccn1
Show InChI InChI=1S/C28H38N6O4/c35-27(21-8-16-34(18-21)25-5-1-2-12-29-25)32-24(28(36)37)10-15-33-14-9-23(19-33)38-17-11-22-7-6-20-4-3-13-30-26(20)31-22/h1-2,5-7,12,21,23-24H,3-4,8-11,13-19H2,(H,30,31)(H,32,35)(H,36,37)/t21-,23-,24+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448901
PNG
(US10696672, Compound 133)
Show SMILES OC(=O)[C@H](CCN1CC[C@H](C1)OCCc1ccc2CCCNc2n1)NC(=O)[C@@H]1CCCN1c1ccccc1
Show InChI InChI=1S/C29H39N5O4/c35-28(26-9-5-16-34(26)23-7-2-1-3-8-23)32-25(29(36)37)13-18-33-17-12-24(20-33)38-19-14-22-11-10-21-6-4-15-30-27(21)31-22/h1-3,7-8,10-11,24-26H,4-6,9,12-20H2,(H,30,31)(H,32,35)(H,36,37)/t24-,25+,26+/m1/s1
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n/an/a 625n/an/an/an/an/an/a



Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448902
PNG
(US10696672, Compound 134)
Show SMILES CC(C)(O)CC1NCCC1C(=O)N[C@@H](CCN1CC(C1)OCCc1ccc2CCCNc2n1)C(O)=O
Show InChI InChI=1S/C26H41N5O5/c1-26(2,35)14-22-20(7-11-27-22)24(32)30-21(25(33)34)8-12-31-15-19(16-31)36-13-9-18-6-5-17-4-3-10-28-23(17)29-18/h5-6,19-22,27,35H,3-4,7-16H2,1-2H3,(H,28,29)(H,30,32)(H,33,34)/t20?,21-,22?/m0/s1
PDB

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n/an/a 625n/an/an/an/an/an/a



Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448808
PNG
(US10696672, Compound 40)
Show SMILES CC(C)(C)OC(=O)N[C@@H](CCN1CC(CCc2ccc3CCCNc3n2)CC(F)(F)C1)C(O)=O
Show InChI InChI=1S/C24H36F2N4O4/c1-23(2,3)34-22(33)29-19(21(31)32)10-12-30-14-16(13-24(25,26)15-30)6-8-18-9-7-17-5-4-11-27-20(17)28-18/h7,9,16,19H,4-6,8,10-15H2,1-3H3,(H,27,28)(H,29,33)(H,31,32)/t16?,19-/m0/s1
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n/an/a 625n/an/an/an/an/an/a



Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448907
PNG
(US10696672, Compound 139)
Show SMILES OC(=O)[C@H](CCN1CC(CCc2ccc3CCCNc3n2)C1)NC(=O)c1c(Cl)cccc1Cl
Show InChI InChI=1S/C24H28Cl2N4O3/c25-18-4-1-5-19(26)21(18)23(31)29-20(24(32)33)10-12-30-13-15(14-30)6-8-17-9-7-16-3-2-11-27-22(16)28-17/h1,4-5,7,9,15,20H,2-3,6,8,10-14H2,(H,27,28)(H,29,31)(H,32,33)/t20-/m0/s1
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n/an/a 625n/an/an/an/an/an/a



Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448810
PNG
(US10696672, Compound 42)
Show SMILES Cc1cc(C)n(n1)-c1cccc(c1)C(=O)N[C@@H](CCN1CC(CCc2ccc3CCCNc3n2)CC(F)(F)C1)C(O)=O
Show InChI InChI=1S/C31H38F2N6O3/c1-20-15-21(2)39(37-20)26-7-3-5-24(16-26)29(40)36-27(30(41)42)12-14-38-18-22(17-31(32,33)19-38)8-10-25-11-9-23-6-4-13-34-28(23)35-25/h3,5,7,9,11,15-16,22,27H,4,6,8,10,12-14,17-19H2,1-2H3,(H,34,35)(H,36,40)(H,41,42)/t22?,27-/m0/s1
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n/an/a 625n/an/an/an/an/an/a



Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448896
PNG
(US10696672, Compound 128)
Show SMILES CC(C)(C(=O)N[C@@H](CCN1CC(C1)OCCc1ccc2CCCNc2n1)C(O)=O)c1cccnc1
Show InChI InChI=1S/C26H35N5O4/c1-26(2,19-6-4-11-27-15-19)25(34)30-22(24(32)33)9-13-31-16-21(17-31)35-14-10-20-8-7-18-5-3-12-28-23(18)29-20/h4,6-8,11,15,21-22H,3,5,9-10,12-14,16-17H2,1-2H3,(H,28,29)(H,30,34)(H,32,33)/t22-/m0/s1
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n/an/a 625n/an/an/an/an/an/a



Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448898
PNG
(US10696672, Compound 130)
Show SMILES CC(C)(Cc1ccccc1)C(=O)N[C@@H](CCN1CC(C1)OCCc1ccc2CCCNc2n1)C(O)=O
Show InChI InChI=1S/C28H38N4O4/c1-28(2,17-20-7-4-3-5-8-20)27(35)31-24(26(33)34)12-15-32-18-23(19-32)36-16-13-22-11-10-21-9-6-14-29-25(21)30-22/h3-5,7-8,10-11,23-24H,6,9,12-19H2,1-2H3,(H,29,30)(H,31,35)(H,33,34)/t24-/m0/s1
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n/an/a 625n/an/an/an/an/an/a



Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448866
PNG
(US10696672, Compound 98)
Show SMILES Cc1nn(C)cc1-c1nn(C)c2c(cccc12)C(=O)N[C@@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)C(O)=O
Show InChI InChI=1S/C32H40N8O3/c1-20-26(19-38(2)36-20)28-24-7-4-8-25(29(24)39(3)37-28)31(41)35-27(32(42)43)14-17-40-16-13-21(18-40)9-11-23-12-10-22-6-5-15-33-30(22)34-23/h4,7-8,10,12,19,21,27H,5-6,9,11,13-18H2,1-3H3,(H,33,34)(H,35,41)(H,42,43)/t21-,27+/m1/s1
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n/an/a 625n/an/an/an/an/an/a



Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448887
PNG
(US10696672, Compound 119)
Show SMILES CC(C)(Cc1ccccc1)C(=O)N[C@@H](CCN1CC[C@H](C1)OCCc1ccc2CCCNc2n1)C(O)=O
Show InChI InChI=1S/C29H40N4O4/c1-29(2,19-21-7-4-3-5-8-21)28(36)32-25(27(34)35)13-17-33-16-12-24(20-33)37-18-14-23-11-10-22-9-6-15-30-26(22)31-23/h3-5,7-8,10-11,24-25H,6,9,12-20H2,1-2H3,(H,30,31)(H,32,36)(H,34,35)/t24-,25+/m1/s1
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n/an/a 625n/an/an/an/an/an/a



Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448762
PNG
((R)-2-(2,6-dichlorobenzamido)-4-((R)- | US10696672...)
Show SMILES OC(=O)[C@@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)c1c(Cl)cccc1Cl
Show InChI InChI=1S/C25H30Cl2N4O3/c26-19-4-1-5-20(27)22(19)24(32)30-21(25(33)34)11-14-31-13-10-16(15-31)6-8-18-9-7-17-3-2-12-28-23(17)29-18/h1,4-5,7,9,16,21H,2-3,6,8,10-15H2,(H,28,29)(H,30,32)(H,33,34)/t16-,21-/m1/s1
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n/an/a 625n/an/an/an/an/an/a



Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448882
PNG
(US10696672, Compound 114)
Show SMILES OC(=O)[C@H](CCN1CC[C@H](C1)OCCc1ccc2CCCNc2n1)NC(=O)c1c(Cl)cccc1Cl
Show InChI InChI=1S/C25H30Cl2N4O4/c26-19-4-1-5-20(27)22(19)24(32)30-21(25(33)34)9-13-31-12-8-18(15-31)35-14-10-17-7-6-16-3-2-11-28-23(16)29-17/h1,4-7,18,21H,2-3,8-15H2,(H,28,29)(H,30,32)(H,33,34)/t18-,21+/m1/s1
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n/an/a 625n/an/an/an/an/an/a



Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448905
PNG
(US10696672, Compound 137)
Show SMILES CC(C)(Cc1ccccc1)C(=O)N[C@@H](CCN1CC(CCc2ccc3CCCNc3n2)C1)C(O)=O
Show InChI InChI=1S/C28H38N4O3/c1-28(2,17-20-7-4-3-5-8-20)27(35)31-24(26(33)34)14-16-32-18-21(19-32)10-12-23-13-11-22-9-6-15-29-25(22)30-23/h3-5,7-8,11,13,21,24H,6,9-10,12,14-19H2,1-2H3,(H,29,30)(H,31,35)(H,33,34)/t24-/m0/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448915
PNG
(US10696672, Compound 147)
Show SMILES OC(=O)[C@@H](CCN1CC[C@H](CCc2ccc3CCCNc3n2)C1)NC(=O)c1c(Cl)cccc1Cl
Show InChI InChI=1S/C25H30Cl2N4O3/c26-19-4-1-5-20(27)22(19)24(32)30-21(25(33)34)11-14-31-13-10-16(15-31)6-8-18-9-7-17-3-2-12-28-23(17)29-18/h1,4-5,7,9,16,21H,2-3,6,8,10-15H2,(H,28,29)(H,30,32)(H,33,34)/t16-,21+/m0/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448904
PNG
(US10696672, Compound 136)
Show SMILES CC(C)(C(=O)N[C@@H](CCN1CC(CCc2ccc3CCCNc3n2)C1)C(O)=O)c1ccccc1
Show InChI InChI=1S/C27H36N4O3/c1-27(2,21-8-4-3-5-9-21)26(34)30-23(25(32)33)14-16-31-17-19(18-31)10-12-22-13-11-20-7-6-15-28-24(20)29-22/h3-5,8-9,11,13,19,23H,6-7,10,12,14-18H2,1-2H3,(H,28,29)(H,30,34)(H,32,33)/t23-/m0/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448908
PNG
(US10696672, Compound 140 | US10696672, Compound 14...)
Show SMILES OC(=O)[C@H](CCN1C2CCC1C(CCc1ccc3CCCNc3n1)C2)NC(=O)c1cc(F)cc(c1)C(F)(F)F
Show InChI InChI=1S/C28H32F4N4O3/c29-20-13-18(12-19(15-20)28(30,31)32)26(37)35-23(27(38)39)9-11-36-22-7-8-24(36)17(14-22)4-6-21-5-3-16-2-1-10-33-25(16)34-21/h3,5,12-13,15,17,22-24H,1-2,4,6-11,14H2,(H,33,34)(H,35,37)(H,38,39)/t17?,22?,23-,24?/m0/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448775
PNG
((S)-2-(3-(3,5-dimethyl-1H-pyrazol-1- | US10696672,...)
Show SMILES Cc1cc(C)n(n1)-c1cccc(c1)C(=O)N[C@@H](CCN1CCC(CCc2ccc3CCCNc3n2)CC1)C(O)=O
Show InChI InChI=1S/C31H40N6O3/c1-21-19-22(2)37(35-21)27-7-3-5-25(20-27)30(38)34-28(31(39)40)14-18-36-16-12-23(13-17-36)8-10-26-11-9-24-6-4-15-32-29(24)33-26/h3,5,7,9,11,19-20,23,28H,4,6,8,10,12-18H2,1-2H3,(H,32,33)(H,34,38)(H,39,40)/t28-/m0/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448800
PNG
(US10696672, Compound 33 | US10696672, Compound 34)
Show SMILES OC(=O)[C@H](CCN1CCC(CC1)NC(=O)c1ccc2CCCNc2n1)NC(=O)C1CCC(F)(F)CC1
Show InChI InChI=1S/C25H35F2N5O4/c26-25(27)10-5-17(6-11-25)22(33)31-20(24(35)36)9-15-32-13-7-18(8-14-32)29-23(34)19-4-3-16-2-1-12-28-21(16)30-19/h3-4,17-18,20H,1-2,5-15H2,(H,28,30)(H,29,34)(H,31,33)(H,35,36)/t20-/m0/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448894
PNG
(US10696672, Compound 126)
Show SMILES OC(=O)[C@H](CCN1CC[C@H](C1)OCCc1ccc2CCCNc2n1)NC(=O)[C@H]1CCN(C1)c1ccccn1
Show InChI InChI=1S/C28H38N6O4/c35-27(21-8-16-34(18-21)25-5-1-2-12-29-25)32-24(28(36)37)10-15-33-14-9-23(19-33)38-17-11-22-7-6-20-4-3-13-30-26(20)31-22/h1-2,5-7,12,21,23-24H,3-4,8-11,13-19H2,(H,30,31)(H,32,35)(H,36,37)/t21-,23+,24-/m0/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448903
PNG
(US10696672, Compound 135)
Show SMILES OC(=O)[C@H](CCN1CC(CCc2ccc3CCCNc3n2)C1)NC(=O)C1CCCN1Cc1ccccc1
Show InChI InChI=1S/C29H39N5O3/c35-28(26-9-5-16-34(26)20-21-6-2-1-3-7-21)32-25(29(36)37)14-17-33-18-22(19-33)10-12-24-13-11-23-8-4-15-30-27(23)31-24/h1-3,6-7,11,13,22,25-26H,4-5,8-10,12,14-20H2,(H,30,31)(H,32,35)(H,36,37)/t25-,26?/m0/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448913
PNG
(US10696672, Compound 145)
Show SMILES CCC(CC)C(=O)N[C@@H](CCN1C2CCC1C(CCc1ccc3CCCNc3n1)C2)C(O)=O
Show InChI InChI=1S/C26H40N4O3/c1-3-17(4-2)25(31)29-22(26(32)33)13-15-30-21-11-12-23(30)19(16-21)8-10-20-9-7-18-6-5-14-27-24(18)28-20/h7,9,17,19,21-23H,3-6,8,10-16H2,1-2H3,(H,27,28)(H,29,31)(H,32,33)/t19?,21?,22-,23?/m0/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448879
PNG
(US10696672, Compound 111)
Show SMILES CC(C)(C)OC(=O)N[C@@H](CCN1CC[C@H](C1)OCc1ccc2CCCNc2n1)C(O)=O
Show InChI InChI=1S/C22H34N4O5/c1-22(2,3)31-21(29)25-18(20(27)28)9-12-26-11-8-17(13-26)30-14-16-7-6-15-5-4-10-23-19(15)24-16/h6-7,17-18H,4-5,8-14H2,1-3H3,(H,23,24)(H,25,29)(H,27,28)/t17-,18+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448910
PNG
(US10696672, Compound 142)
Show SMILES CC(C)(O)CN1CCC[C@H]1C(=O)N[C@@H](CCN1CC[C@H](C1)OCCc1ccc2CCCNc2n1)C(O)=O
Show InChI InChI=1S/C27H43N5O5/c1-27(2,36)18-32-13-4-6-23(32)25(33)30-22(26(34)35)10-15-31-14-9-21(17-31)37-16-11-20-8-7-19-5-3-12-28-24(19)29-20/h7-8,21-23,36H,3-6,9-18H2,1-2H3,(H,28,29)(H,30,33)(H,34,35)/t21-,22+,23+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448912
PNG
(US10696672, Compound 144)
Show SMILES CC(C)(C(=O)N[C@@H](CCN1CC(CCc2ccc3CCCNc3n2)C1)C(O)=O)c1cccnc1
Show InChI InChI=1S/C26H35N5O3/c1-26(2,20-6-4-12-27-15-20)25(34)30-22(24(32)33)11-14-31-16-18(17-31)7-9-21-10-8-19-5-3-13-28-23(19)29-21/h4,6,8,10,12,15,18,22H,3,5,7,9,11,13-14,16-17H2,1-2H3,(H,28,29)(H,30,34)(H,32,33)/t22-/m0/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448780
PNG
((S)-2-(4-morpholinobenzamido)-4- | US10696672, Com...)
Show SMILES OC(=O)[C@H](CCN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)NC(=O)c1ccc(cc1)N1CCOCC1
Show InChI InChI=1S/C29H39N5O4/c35-28(23-5-9-25(10-6-23)34-16-18-38-19-17-34)32-26(29(36)37)12-15-33-14-11-21(20-33)3-7-24-8-4-22-2-1-13-30-27(22)31-24/h4-6,8-10,21,26H,1-3,7,11-20H2,(H,30,31)(H,32,35)(H,36,37)/t21-,26+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448880
PNG
(US10696672, Compound 112)
Show SMILES OC(=O)[C@H](CCN1CC[C@H](C1)OCc1ccc2CCCNc2n1)NC(=O)c1ccccc1
Show InChI InChI=1S/C24H30N4O4/c29-23(18-5-2-1-3-6-18)27-21(24(30)31)11-14-28-13-10-20(15-28)32-16-19-9-8-17-7-4-12-25-22(17)26-19/h1-3,5-6,8-9,20-21H,4,7,10-16H2,(H,25,26)(H,27,29)(H,30,31)/t20-,21+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448881
PNG
(US10696672, Compound 113)
Show SMILES Cc1cc(C)n(n1)-c1cccc(c1)C(=O)N[C@@H](CCN1CC[C@H](C1)OCc1ccc2CCCNc2n1)C(O)=O
Show InChI InChI=1S/C29H36N6O4/c1-19-15-20(2)35(33-19)24-7-3-5-22(16-24)28(36)32-26(29(37)38)11-14-34-13-10-25(17-34)39-18-23-9-8-21-6-4-12-30-27(21)31-23/h3,5,7-9,15-16,25-26H,4,6,10-14,17-18H2,1-2H3,(H,30,31)(H,32,36)(H,37,38)/t25-,26+/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448884
PNG
(US10696672, Compound 116)
Show SMILES CC(=O)N1CCN(CC[C@H](NC(=O)c2ccccc2)C(O)=O)C[C@@H]1CCc1ccc2CCCNc2n1
Show InChI InChI=1S/C27H35N5O4/c1-19(33)32-17-16-31(15-13-24(27(35)36)30-26(34)21-6-3-2-4-7-21)18-23(32)12-11-22-10-9-20-8-5-14-28-25(20)29-22/h2-4,6-7,9-10,23-24H,5,8,11-18H2,1H3,(H,28,29)(H,30,34)(H,35,36)/t23-,24-/m0/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448911
PNG
(US10696672, Compound 143)
Show SMILES OC(=O)[C@H](CCN1CC(CCc2ccc3CCCNc3n2)C1)NC(=O)[C@@H]1CCNC1Cc1ccccc1
Show InChI InChI=1S/C29H39N5O3/c35-28(24-12-15-30-26(24)17-20-5-2-1-3-6-20)33-25(29(36)37)13-16-34-18-21(19-34)8-10-23-11-9-22-7-4-14-31-27(22)32-23/h1-3,5-6,9,11,21,24-26,30H,4,7-8,10,12-19H2,(H,31,32)(H,33,35)(H,36,37)/t24-,25+,26?/m1/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB6


(Homo sapiens (Human))
BDBM448800
PNG
(US10696672, Compound 33 | US10696672, Compound 34)
Show SMILES OC(=O)[C@H](CCN1CCC(CC1)NC(=O)c1ccc2CCCNc2n1)NC(=O)C1CCC(F)(F)CC1
Show InChI InChI=1S/C25H35F2N5O4/c26-25(27)10-5-17(6-11-25)22(33)31-20(24(35)36)9-15-32-13-7-18(8-14-32)29-23(34)19-4-3-16-2-1-12-28-21(16)30-19/h3-4,17-18,20H,1-2,5-15H2,(H,28,30)(H,29,34)(H,31,33)(H,35,36)/t20-/m0/s1
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Pliant Therapeutics, Inc.

US Patent


Assay Description
Microplates were coated with recombinant human integrin αvβ6 (2 ug/ml) in PBS (100 ul/well 25 C., overnight). The coating solution was rem...


US Patent US10696672 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%