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Patent code US10696689

Compile Data Set for Download or QSAR
Found 23 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM449019
PNG
(2-{4-[(4αS,8αS)-octahydro-1H-pyrido[3,4-...)
Show SMILES COc1cc(cc2[nH]c(nc12)-c1c(N)ncc(-c2cc(C)cc(F)c2)c1N1CC[C@@H]2NCCO[C@H]2C1)C#N
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n/an/an/an/a<0.100n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
On the day of the assay, the media is aspirated and the cells are treated with 50 μL of 1.6 μM NKH477 (Sigma # N3290) plus various dilution...


US Patent US10696689 (2020)

More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM449015
PNG
(US10696689, Compound 3-12)
Show SMILES CNc1ncc(-c2cccc(F)c2)c(N2CCC3NCCOC3C2)c1-c1nc2c(OC)cc(cc2[nH]1)C#N
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n/an/an/an/a>1n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
On the day of the assay, the media is aspirated and the cells are treated with 50 μL of 1.6 μM NKH477 (Sigma # N3290) plus various dilution...


US Patent US10696689 (2020)

More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM449007
PNG
(US10696689, Compound 3-2)
Show SMILES Nc1ncc(-c2cc(F)cc(F)c2)c(N2CCC3NCCOC3C2)c1-c1nc2c(F)cc(F)cc2[nH]1
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n/an/an/an/a 0.550n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
On the day of the assay, the media is aspirated and the cells are treated with 50 μL of 1.6 μM NKH477 (Sigma # N3290) plus various dilution...


US Patent US10696689 (2020)

More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM449009
PNG
(US10696689, Compound 3-6)
Show SMILES CNc1ncc(-c2cc(F)cc(F)c2)c(N2CCC3NCCOC3C2)c1-c1nc2c(F)cc(F)cc2[nH]1
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n/an/an/an/a 0.550n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
On the day of the assay, the media is aspirated and the cells are treated with 50 μL of 1.6 μM NKH477 (Sigma # N3290) plus various dilution...


US Patent US10696689 (2020)

More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM448916
PNG
(US10696689, Compound 1-1)
Show SMILES COc1cc(cc2[nH]c(nc12)-c1c(N)ncc(-c2cc(C)cc(F)c2)c1N1CCC(N)CC1)C#N
Show InChI InChI=1S/C26H26FN7O/c1-14-7-16(11-17(27)8-14)19-13-31-25(30)22(24(19)34-5-3-18(29)4-6-34)26-32-20-9-15(12-28)10-21(35-2)23(20)33-26/h7-11,13,18H,3-6,29H2,1-2H3,(H2,30,31)(H,32,33)
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CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
On the day of the assay, the media is aspirated and the cells are treated with 50 μL of 1.6 μM NKH477 (Sigma # N3290) plus various dilution...


US Patent US10696689 (2020)

More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM449005
PNG
(4-(4-aminopiperidin-1-yl)-3-(6-fluoro-4-methoxy-1H...)
Show SMILES COc1cc(F)cc2nc([nH]c12)-c1c(ncc(-c2cc(C)cc(F)c2)c1N1CCC(N)CC1)C(N)=O
Show InChI InChI=1S/C26H26F2N6O2/c1-13-7-14(9-15(27)8-13)18-12-31-23(25(30)35)21(24(18)34-5-3-17(29)4-6-34)26-32-19-10-16(28)11-20(36-2)22(19)33-26/h7-12,17H,3-6,29H2,1-2H3,(H2,30,35)(H,32,33)
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n/an/an/an/a 0.550n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
On the day of the assay, the media is aspirated and the cells are treated with 50 μL of 1.6 μM NKH477 (Sigma # N3290) plus various dilution...


US Patent US10696689 (2020)

More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM449012
PNG
(US10696689, Compound 3-9)
Show SMILES COc1cc(F)cc2[nH]c(nc12)-c1c(N)ncc(-c2cccc(F)c2)c1N1CCC2NCCOC2C1
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n/an/an/an/a 0.550n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
On the day of the assay, the media is aspirated and the cells are treated with 50 μL of 1.6 μM NKH477 (Sigma # N3290) plus various dilution...


US Patent US10696689 (2020)

More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM449020
PNG
(US10696689, Compound 3-17)
Show SMILES COc1cc(F)cc2[nH]c(nc12)-c1c(N)ncc(-c2cc(F)cc(Cl)c2)c1N1CCC2NCCOC2C1
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n/an/an/an/a<0.100n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
On the day of the assay, the media is aspirated and the cells are treated with 50 μL of 1.6 μM NKH477 (Sigma # N3290) plus various dilution...


US Patent US10696689 (2020)

More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM449006
PNG
(US10696689, Compound 3-1)
Show SMILES Cc1cc(F)cc(c1)-c1cnc(N)c(-c2nc3c(F)cc(F)cc3[nH]2)c1N1CCC2NCCOC2C1
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n/an/an/an/a<0.100n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
On the day of the assay, the media is aspirated and the cells are treated with 50 μL of 1.6 μM NKH477 (Sigma # N3290) plus various dilution...


US Patent US10696689 (2020)

More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM449017
PNG
(US10696689, Compound 3-14)
Show SMILES COc1cc(F)cc2[nH]c(nc12)-c1c(N)ncc(-c2cc(C)cc(F)c2)c1N1CCC2NCCOC2C1
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n/an/an/an/a<0.100n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
On the day of the assay, the media is aspirated and the cells are treated with 50 μL of 1.6 μM NKH477 (Sigma # N3290) plus various dilution...


US Patent US10696689 (2020)

More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM449018
PNG
(US10696689, Compound 3-15)
Show SMILES CNc1ncc(-c2cc(C)cc(F)c2)c(N2CCC3NCCOC3C2)c1-c1nc2c(OC)cc(F)cc2[nH]1
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CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
On the day of the assay, the media is aspirated and the cells are treated with 50 μL of 1.6 μM NKH477 (Sigma # N3290) plus various dilution...


US Patent US10696689 (2020)

More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM448999
PNG
(US10696689, Compound 1-2)
Show SMILES COc1cc(cc2[nH]c(nc12)-c1c(N)ncc(-c2cc(F)cc(Cl)c2)c1N1CCC(N)CC1)C#N
Show InChI InChI=1S/C25H23ClFN7O/c1-35-20-7-13(11-28)6-19-22(20)33-25(32-19)21-23(34-4-2-17(29)3-5-34)18(12-31-24(21)30)14-8-15(26)10-16(27)9-14/h6-10,12,17H,2-5,29H2,1H3,(H2,30,31)(H,32,33)
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n/an/an/an/a 0.550n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
On the day of the assay, the media is aspirated and the cells are treated with 50 μL of 1.6 μM NKH477 (Sigma # N3290) plus various dilution...


US Patent US10696689 (2020)

More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM449003
PNG
(US10696689, Compound 2-1 | methyl 4-(4-aminopiperi...)
Show SMILES COC(=O)c1ncc(-c2cc(C)cc(F)c2)c(N2CCC(N)CC2)c1-c1nc2cc(F)cc(OC)c2[nH]1
Show InChI InChI=1S/C27H27F2N5O3/c1-14-8-15(10-16(28)9-14)19-13-31-24(27(35)37-3)22(25(19)34-6-4-18(30)5-7-34)26-32-20-11-17(29)12-21(36-2)23(20)33-26/h8-13,18H,4-7,30H2,1-3H3,(H,32,33)
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n/an/an/an/a 0.550n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
On the day of the assay, the media is aspirated and the cells are treated with 50 μL of 1.6 μM NKH477 (Sigma # N3290) plus various dilution...


US Patent US10696689 (2020)

More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM449004
PNG
(4-(4-aminopiperidin-1-yl)-3-(6-fluoro-4-methoxy-1H...)
Show SMILES COc1cc(F)cc2nc([nH]c12)-c1c(ncc(-c2cc(C)cc(F)c2)c1N1CCC(N)CC1)C#N
Show InChI InChI=1S/C26H24F2N6O/c1-14-7-15(9-16(27)8-14)19-13-31-21(12-29)23(25(19)34-5-3-18(30)4-6-34)26-32-20-10-17(28)11-22(35-2)24(20)33-26/h7-11,13,18H,3-6,30H2,1-2H3,(H,32,33)
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n/an/an/an/a 0.550n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
On the day of the assay, the media is aspirated and the cells are treated with 50 μL of 1.6 μM NKH477 (Sigma # N3290) plus various dilution...


US Patent US10696689 (2020)

More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM449013
PNG
(US10696689, Compound 3-10)
Show SMILES CNc1ncc(-c2cccc(F)c2)c(N2CCC3NCCOC3C2)c1-c1nc2c(OC)cc(F)cc2[nH]1
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n/an/an/an/a 0.550n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
On the day of the assay, the media is aspirated and the cells are treated with 50 μL of 1.6 μM NKH477 (Sigma # N3290) plus various dilution...


US Patent US10696689 (2020)

More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM449008
PNG
(US10696689, Compound 3-3)
Show SMILES Nc1ncc(-c2cccc(F)c2)c(N2CCC3NCCOC3C2)c1-c1nc2c(F)cc(F)cc2[nH]1
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n/an/an/an/a 0.550n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
On the day of the assay, the media is aspirated and the cells are treated with 50 μL of 1.6 μM NKH477 (Sigma # N3290) plus various dilution...


US Patent US10696689 (2020)

More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM449011
PNG
(US10696689, Compound 3-8)
Show SMILES COc1cc(F)cc(c1)-c1cnc(N)c(-c2nc3c(F)cc(F)cc3[nH]2)c1N1CCC2NCCOC2C1
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CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
On the day of the assay, the media is aspirated and the cells are treated with 50 μL of 1.6 μM NKH477 (Sigma # N3290) plus various dilution...


US Patent US10696689 (2020)

More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM449016
PNG
(US10696689, Compound 3-13)
Show SMILES CNc1ncc(-c2cc(F)cc(Cl)c2)c(N2CCC3NCCOC3C2)c1-c1nc2c(OC)cc(F)cc2[nH]1
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CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
On the day of the assay, the media is aspirated and the cells are treated with 50 μL of 1.6 μM NKH477 (Sigma # N3290) plus various dilution...


US Patent US10696689 (2020)

More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM449021
PNG
(US10696689, Compound 3-18)
Show SMILES COc1cc(cc2[nH]c(nc12)-c1c(N)ncc(-c2cc(F)cc(F)c2)c1N1CCC2NCCOC2C1)C#N
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n/an/an/an/a 0.550n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
On the day of the assay, the media is aspirated and the cells are treated with 50 μL of 1.6 μM NKH477 (Sigma # N3290) plus various dilution...


US Patent US10696689 (2020)

More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM449002
PNG
(2-[4-(4-aminopiperidin-1-yl)-2-(dimethylamino)-5-(...)
Show SMILES COc1cc(cc2nc([nH]c12)-c1c(ncc(-c2cc(C)cc(F)c2)c1N1CCC(N)CC1)N(C)C)C#N
Show InChI InChI=1S/C28H30FN7O/c1-16-9-18(13-19(29)10-16)21-15-32-28(35(2)3)24(26(21)36-7-5-20(31)6-8-36)27-33-22-11-17(14-30)12-23(37-4)25(22)34-27/h9-13,15,20H,5-8,31H2,1-4H3,(H,33,34)
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CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
On the day of the assay, the media is aspirated and the cells are treated with 50 μL of 1.6 μM NKH477 (Sigma # N3290) plus various dilution...


US Patent US10696689 (2020)

More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM449010
PNG
(US10696689, Compound 3-7)
Show SMILES Nc1ncc(-c2cc(F)cc(Cl)c2)c(N2CCC3NCCOC3C2)c1-c1nc2c(F)cc(F)cc2[nH]1
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CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
On the day of the assay, the media is aspirated and the cells are treated with 50 μL of 1.6 μM NKH477 (Sigma # N3290) plus various dilution...


US Patent US10696689 (2020)

More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM449014
PNG
(US10696689, Compound 3-11)
Show SMILES COc1cc(cc2[nH]c(nc12)-c1c(N)ncc(-c2cccc(F)c2)c1N1CCC2NCCOC2C1)C#N
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n/an/an/an/a 0.550n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
On the day of the assay, the media is aspirated and the cells are treated with 50 μL of 1.6 μM NKH477 (Sigma # N3290) plus various dilution...


US Patent US10696689 (2020)

More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM449022
PNG
(US10696689, Compound 3-19)
Show SMILES Nc1ncc(-c2cc(F)cc(F)c2)c(N2CCC3NCCOC3C2)c1-c1nc2c(F)cc(cc2[nH]1)C#N
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n/an/an/an/a 0.550n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
On the day of the assay, the media is aspirated and the cells are treated with 50 μL of 1.6 μM NKH477 (Sigma # N3290) plus various dilution...


US Patent US10696689 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%