BindingDB logo
myBDB logout

Patent code US10696692

Compile Data Set for Download or QSAR

Found 374 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM449375
PNG
(N-[[4-[(1-tetrahydropyran-4- yl-4- piperidyl)sulfi...)
Show SMILES O=C(NCc1ccc(cc1)S(=O)C1CCN(CC1)C1CCOCC1)N1Cc2ccncc2C1
Show InChI InChI=1S/C25H32N4O3S/c30-25(29-17-20-5-10-26-16-21(20)18-29)27-15-19-1-3-23(4-2-19)33(31)24-6-11-28(12-7-24)22-8-13-32-14-9-22/h1-5,10,16,22,24H,6-9,11-15,17-18H2,(H,27,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 2.02n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US10696692 (2020)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM449131
PNG
(Imidazo[1,2-a]pyridine-6- carboxylic acid 4-[4-(4-...)
Show SMILES CN1CCN(CC1)C(=O)C1CCN(CC1)S(=O)(=O)c1ccc(CNC(=O)c2ccc3nccn3c2)cc1
Show InChI InChI=1S/C26H32N6O4S/c1-29-14-16-30(17-15-29)26(34)21-8-11-32(12-9-21)37(35,36)23-5-2-20(3-6-23)18-28-25(33)22-4-7-24-27-10-13-31(24)19-22/h2-7,10,13,19,21H,8-9,11-12,14-18H2,1H3,(H,28,33)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 2.70n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US10696692 (2020)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM449216
PNG
(N-[[4-[(6-methyl-2,6- diazaspiro[3.4]octan-2- yl)s...)
Show SMILES CN1CCC2(CN(C2)S(=O)(=O)c2ccc(CNC(=O)c3cc4ccncc4o3)cc2)C1
Show InChI InChI=1S/C22H24N4O4S/c1-25-9-7-22(13-25)14-26(15-22)31(28,29)18-4-2-16(3-5-18)11-24-21(27)19-10-17-6-8-23-12-20(17)30-19/h2-6,8,10,12H,7,9,11,13-15H2,1H3,(H,24,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 2.83n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US10696692 (2020)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM449216
PNG
(N-[[4-[(6-methyl-2,6- diazaspiro[3.4]octan-2- yl)s...)
Show SMILES CN1CCC2(CN(C2)S(=O)(=O)c2ccc(CNC(=O)c3cc4ccncc4o3)cc2)C1
Show InChI InChI=1S/C22H24N4O4S/c1-25-9-7-22(13-25)14-26(15-22)31(28,29)18-4-2-16(3-5-18)11-24-21(27)19-10-17-6-8-23-12-20(17)30-19/h2-6,8,10,12H,7,9,11,13-15H2,1H3,(H,24,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 2.83n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US10696692 (2020)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM449374
PNG
(N-[[4-[[1-(2,2,2- tnfluoroethyl)-4- piperidyl]sulf...)
Show SMILES FC(F)(F)CN1CCC(CC1)S(=O)c1ccc(CNC(=O)c2ccc3nccn3c2)cc1
Show InChI InChI=1S/C22H23F3N4O2S/c23-22(24,25)15-28-10-7-19(8-11-28)32(31)18-4-1-16(2-5-18)13-27-21(30)17-3-6-20-26-9-12-29(20)14-17/h1-6,9,12,14,19H,7-8,10-11,13,15H2,(H,27,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 2.93n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US10696692 (2020)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM449095
PNG
(US10696692, Example 73 | US10696692, Example 74 | ...)
Show SMILES FC1(F)CCC2CN(CC12)S(=O)(=O)c1ccc(CNC(=O)c2ccc3nccn3c2)cc1
Show InChI InChI=1S/C22H22F2N4O3S/c23-22(24)8-7-16-13-28(14-19(16)22)32(30,31)18-4-1-15(2-5-18)11-26-21(29)17-3-6-20-25-9-10-27(20)12-17/h1-6,9-10,12,16,19H,7-8,11,13-14H2,(H,26,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 3n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US10696692 (2020)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM449132
PNG
(Imidazo[1,2-a]pyridine-6- carboxylic acid 4-[4-(4-...)
Show SMILES CN1CCN(CC1)C1CCN(CC1)S(=O)(=O)c1ccc(CNC(=O)c2ccc3nccn3c2)cc1
Show InChI InChI=1S/C25H32N6O3S/c1-28-14-16-29(17-15-28)22-8-11-31(12-9-22)35(33,34)23-5-2-20(3-6-23)18-27-25(32)21-4-7-24-26-10-13-30(24)19-21/h2-7,10,13,19,22H,8-9,11-12,14-18H2,1H3,(H,27,32)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 3.10n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US10696692 (2020)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50438962
PNG
(CHEMBL2420637 | US10696692, Example 6)
Show SMILES O=C(NCc1ccc(cc1)S(=O)(=O)N1CCCCC1)c1cnc2nccn2c1
Show InChI InChI=1S/C19H21N5O3S/c25-18(16-13-22-19-20-8-11-23(19)14-16)21-12-15-4-6-17(7-5-15)28(26,27)24-9-2-1-3-10-24/h4-8,11,13-14H,1-3,9-10,12H2,(H,21,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3.5n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US10696692 (2020)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM449086
PNG
(Imidazo[1,2-a]pyrimidine- 6-carboxylic acid 4-[1- ...)
Show SMILES FC(F)(F)CN1CCC(CC1)S(=O)(=O)c1ccc(CNC(=O)c2cnc3nccn3c2)cc1
Show InChI InChI=1S/C21H22F3N5O3S/c22-21(23,24)14-28-8-5-18(6-9-28)33(31,32)17-3-1-15(2-4-17)11-26-19(30)16-12-27-20-25-7-10-29(20)13-16/h1-4,7,10,12-13,18H,5-6,8-9,11,14H2,(H,26,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 3.70n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US10696692 (2020)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM449086
PNG
(Imidazo[1,2-a]pyrimidine- 6-carboxylic acid 4-[1- ...)
Show SMILES FC(F)(F)CN1CCC(CC1)S(=O)(=O)c1ccc(CNC(=O)c2cnc3nccn3c2)cc1
Show InChI InChI=1S/C21H22F3N5O3S/c22-21(23,24)14-28-8-5-18(6-9-28)33(31,32)17-3-1-15(2-4-17)11-26-19(30)16-12-27-20-25-7-10-29(20)13-16/h1-4,7,10,12-13,18H,5-6,8-9,11,14H2,(H,26,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 3.72n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US10696692 (2020)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM449100
PNG
(Imidazo[1,2-a]pyrimidine- 6-carboxylic acid 4-[1- ...)
Show SMILES O=C(NCc1ccc(cc1)S(=O)(=O)C1CCN(CC1)C1CCOCC1)c1cnc2nccn2c1
Show InChI InChI=1S/C24H29N5O4S/c30-23(19-16-27-24-25-9-12-29(24)17-19)26-15-18-1-3-21(4-2-18)34(31,32)22-5-10-28(11-6-22)20-7-13-33-14-8-20/h1-4,9,12,16-17,20,22H,5-8,10-11,13-15H2,(H,26,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 3.98n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US10696692 (2020)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM449100
PNG
(Imidazo[1,2-a]pyrimidine- 6-carboxylic acid 4-[1- ...)
Show SMILES O=C(NCc1ccc(cc1)S(=O)(=O)C1CCN(CC1)C1CCOCC1)c1cnc2nccn2c1
Show InChI InChI=1S/C24H29N5O4S/c30-23(19-16-27-24-25-9-12-29(24)17-19)26-15-18-1-3-21(4-2-18)34(31,32)22-5-10-28(11-6-22)20-7-13-33-14-8-20/h1-4,9,12,16-17,20,22H,5-8,10-11,13-15H2,(H,26,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 4n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US10696692 (2020)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM449140
PNG
(Imidazo[1,2-a]pyrimidine- 6-carboxylic acid 4-(1- ...)
Show SMILES O=C(NCc1ccc(cc1)S(=O)(=O)C1CCN(CC1)C1COC1)c1cnc2nccn2c1
Show InChI InChI=1S/C22H25N5O4S/c28-21(17-12-25-22-23-7-10-27(22)13-17)24-11-16-1-3-19(4-2-16)32(29,30)20-5-8-26(9-6-20)18-14-31-15-18/h1-4,7,10,12-13,18,20H,5-6,8-9,11,14-15H2,(H,24,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 4.10n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US10696692 (2020)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM449140
PNG
(Imidazo[1,2-a]pyrimidine- 6-carboxylic acid 4-(1- ...)
Show SMILES O=C(NCc1ccc(cc1)S(=O)(=O)C1CCN(CC1)C1COC1)c1cnc2nccn2c1
Show InChI InChI=1S/C22H25N5O4S/c28-21(17-12-25-22-23-7-10-27(22)13-17)24-11-16-1-3-19(4-2-16)32(29,30)20-5-8-26(9-6-20)18-14-31-15-18/h1-4,7,10,12-13,18,20H,5-6,8-9,11,14-15H2,(H,24,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 4.13n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US10696692 (2020)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM449142
PNG
(Thieno[2,3-c]pyridine-2- carboxylic acid 4-(1- oxe...)
Show SMILES O=C(NCc1ccc(cc1)S(=O)(=O)C1CCN(CC1)C1COC1)c1cc2ccncc2s1
Show InChI InChI=1S/C23H25N3O4S2/c27-23(21-11-17-5-8-24-13-22(17)31-21)25-12-16-1-3-19(4-2-16)32(28,29)20-6-9-26(10-7-20)18-14-30-15-18/h1-5,8,11,13,18,20H,6-7,9-10,12,14-15H2,(H,25,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 4.27n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US10696692 (2020)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM449142
PNG
(Thieno[2,3-c]pyridine-2- carboxylic acid 4-(1- oxe...)
Show SMILES O=C(NCc1ccc(cc1)S(=O)(=O)C1CCN(CC1)C1COC1)c1cc2ccncc2s1
Show InChI InChI=1S/C23H25N3O4S2/c27-23(21-11-17-5-8-24-13-22(17)31-21)25-12-16-1-3-19(4-2-16)32(28,29)20-6-9-26(10-7-20)18-14-30-15-18/h1-5,8,11,13,18,20H,6-7,9-10,12,14-15H2,(H,25,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 4.30n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US10696692 (2020)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM449141
PNG
(Imidazo[1,2-a]pyrimidine- 6-carboxylic acid 4-(4- ...)
Show SMILES O=C(NCc1ccc(cc1)S(=O)(=O)N1CCN(CC1)C1COC1)c1cnc2nccn2c1
Show InChI InChI=1S/C21H24N6O4S/c28-20(17-12-24-21-22-5-6-26(21)13-17)23-11-16-1-3-19(4-2-16)32(29,30)27-9-7-25(8-10-27)18-14-31-15-18/h1-6,12-13,18H,7-11,14-15H2,(H,23,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 4.40n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US10696692 (2020)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM449048
PNG
(Imidazo[1,2-a]pyrimidine- 6-carboxylic acid 4-(8- ...)
Show SMILES O=C(NCc1ccc(cc1)S(=O)(=O)N1CC2CCC(C1)O2)c1cnc2nccn2c1
Show InChI InChI=1S/C20H21N5O4S/c26-19(15-10-23-20-21-7-8-24(20)11-15)22-9-14-1-5-18(6-2-14)30(27,28)25-12-16-3-4-17(13-25)29-16/h1-2,5-8,10-11,16-17H,3-4,9,12-13H2,(H,22,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 4.60n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US10696692 (2020)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM449181
PNG
(Imidazo[1,2-a]pyridine-6- carboxylic acid 4-(3-aza...)
Show SMILES O=C(NCc1ccc(cc1)S(=O)(=O)N1CC2CC2C1)c1ccc2nccn2c1
Show InChI InChI=1S/C20H20N4O3S/c25-20(15-3-6-19-21-7-8-23(19)11-15)22-10-14-1-4-18(5-2-14)28(26,27)24-12-16-9-17(16)13-24/h1-8,11,16-17H,9-10,12-13H2,(H,22,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 4.70n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US10696692 (2020)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM449201
PNG
(Furo[2,3-c]pyridine-2- carboxylic acid 4-(1- isobu...)
Show SMILES CC(C)CN1CCC(CC1)S(=O)c1ccc(CNC(=O)c2cc3ccncc3o2)cc1
Show InChI InChI=1S/C24H29N3O3S/c1-17(2)16-27-11-8-21(9-12-27)31(29)20-5-3-18(4-6-20)14-26-24(28)22-13-19-7-10-25-15-23(19)30-22/h3-7,10,13,15,17,21H,8-9,11-12,14,16H2,1-2H3,(H,26,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PDB
UniChem
PDB
US Patent
n/an/a 4.70n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US10696692 (2020)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM449095
PNG
(US10696692, Example 73 | US10696692, Example 74 | ...)
Show SMILES FC1(F)CCC2CN(CC12)S(=O)(=O)c1ccc(CNC(=O)c2ccc3nccn3c2)cc1
Show InChI InChI=1S/C22H22F2N4O3S/c23-22(24)8-7-16-13-28(14-19(16)22)32(30,31)18-4-1-15(2-5-18)11-26-21(29)17-3-6-20-25-9-10-27(20)12-17/h1-6,9-10,12,16,19H,7-8,11,13-14H2,(H,26,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 5n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US10696692 (2020)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM449108
PNG
(Imidazo[1,2-a]pyrimidine- 6-carboxylic acid 4-(1- ...)
Show SMILES CC(=O)N1CCC(CC1)S(=O)(=O)c1ccc(CNC(=O)c2cnc3nccn3c2)cc1
Show InChI InChI=1S/C21H23N5O4S/c1-15(27)25-9-6-19(7-10-25)31(29,30)18-4-2-16(3-5-18)12-23-20(28)17-13-24-21-22-8-11-26(21)14-17/h2-5,8,11,13-14,19H,6-7,9-10,12H2,1H3,(H,23,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 5.10n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US10696692 (2020)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM449108
PNG
(Imidazo[1,2-a]pyrimidine- 6-carboxylic acid 4-(1- ...)
Show SMILES CC(=O)N1CCC(CC1)S(=O)(=O)c1ccc(CNC(=O)c2cnc3nccn3c2)cc1
Show InChI InChI=1S/C21H23N5O4S/c1-15(27)25-9-6-19(7-10-25)31(29,30)18-4-2-16(3-5-18)12-23-20(28)17-13-24-21-22-8-11-26(21)14-17/h2-5,8,11,13-14,19H,6-7,9-10,12H2,1H3,(H,23,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 5.12n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US10696692 (2020)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM449133
PNG
(Imidazo[1,2-a]pyridine-6- carboxylic acid 4-(3- tr...)
Show SMILES FC(F)(F)C1CCN(C1)S(=O)(=O)c1ccc(CNC(=O)c2ccc3nccn3c2)cc1
Show InChI InChI=1S/C20H19F3N4O3S/c21-20(22,23)16-7-9-27(13-16)31(29,30)17-4-1-14(2-5-17)11-25-19(28)15-3-6-18-24-8-10-26(18)12-15/h1-6,8,10,12,16H,7,9,11,13H2,(H,25,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 5.60n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US10696692 (2020)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM449143
PNG
(9-(4-{[(Imidazo[1,2- a]pyridine-6-carbonyl)- amino...)
Show SMILES CC(C)(C)OC(=O)N1CCC2(CC1)CCN(CC2)S(=O)(=O)c1ccc(CNC(=O)c2ccc3nccn3c2)cc1
Show InChI InChI=1S/C29H37N5O5S/c1-28(2,3)39-27(36)32-15-10-29(11-16-32)12-17-34(18-13-29)40(37,38)24-7-4-22(5-8-24)20-31-26(35)23-6-9-25-30-14-19-33(25)21-23/h4-9,14,19,21H,10-13,15-18,20H2,1-3H3,(H,31,35)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 5.80n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US10696692 (2020)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM449066
PNG
(Thieno[2,3-c]pyridine-2- carboxylic acid 4- ((1R,3...)
Show SMILES N[C@@H]1C[C@@H]2CC[C@H](C1)N2S(=O)(=O)c1ccc(CNC(=O)c2cc3ccncc3s2)cc1
Show InChI InChI=1S/C22H24N4O3S2/c23-16-10-17-3-4-18(11-16)26(17)31(28,29)19-5-1-14(2-6-19)12-25-22(27)20-9-15-7-8-24-13-21(15)30-20/h1-2,5-9,13,16-18H,3-4,10-12,23H2,(H,25,27)/t16-,17+,18-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 5.80n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US10696692 (2020)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM449386
PNG
(N-[[4-[[1-(2,2,2- tnfluoroethyl)-4- piperidyl]sulf...)
Show SMILES FC(F)(F)CN1CCC(CC1)S(=O)c1ccc(CNC(=O)N2Cc3ccncc3C2)cc1
Show InChI InChI=1S/C22H25F3N4O2S/c23-22(24,25)15-28-9-6-20(7-10-28)32(31)19-3-1-16(2-4-19)11-27-21(30)29-13-17-5-8-26-12-18(17)14-29/h1-5,8,12,20H,6-7,9-11,13-15H2,(H,27,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 5.82n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US10696692 (2020)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM449261
PNG
(US10696692, Example 242 | tert-butyl 2-[4-[(imidaz...)
Show SMILES CC(C)(C)OC(=O)N1CCCC2(CCN(C2)S(=O)(=O)c2ccc(CNC(=O)c3ccc4nccn4c3)cc2)C1
Show InChI InChI=1S/C28H35N5O5S/c1-27(2,3)38-26(35)32-14-4-11-28(19-32)12-15-33(20-28)39(36,37)23-8-5-21(6-9-23)17-30-25(34)22-7-10-24-29-13-16-31(24)18-22/h5-10,13,16,18H,4,11-12,14-15,17,19-20H2,1-3H3,(H,30,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 6.34n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US10696692 (2020)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM449092
PNG
(US10696692, Example 70 | cis-Imidazo[1,2- a]pyridi...)
Show SMILES FC1(F)C[C@@H]2CN(C[C@@H]2C1)S(=O)(=O)c1ccc(CNC(=O)c2ccc3nccn3c2)cc1
Show InChI InChI=1S/C22H22F2N4O3S/c23-22(24)9-17-13-28(14-18(17)10-22)32(30,31)19-4-1-15(2-5-19)11-26-21(29)16-3-6-20-25-7-8-27(20)12-16/h1-8,12,17-18H,9-11,13-14H2,(H,26,29)/t17-,18+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 6.40n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US10696692 (2020)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM449127
PNG
(Imidazo[1,2-a]pyridine-6-carboxylic acid 4-[4-(2- ...)
Show SMILES CN(C)CCN1CCN(CC1)S(=O)(=O)c1ccc(CNC(=O)c2ccc3nccn3c2)cc1
Show InChI InChI=1S/C23H30N6O3S/c1-26(2)11-12-27-13-15-29(16-14-27)33(31,32)21-6-3-19(4-7-21)17-25-23(30)20-5-8-22-24-9-10-28(22)18-20/h3-10,18H,11-17H2,1-2H3,(H,25,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 6.80n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US10696692 (2020)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM449037
PNG
(Imidazo[1,2-a]pyrimidine- 6-carboxylic acid 4- (mo...)
Show SMILES O=C(NCc1ccc(cc1)S(=O)(=O)N1CCOCC1)c1cnc2nccn2c1
Show InChI InChI=1S/C18H19N5O4S/c24-17(15-12-21-18-19-5-6-22(18)13-15)20-11-14-1-3-16(4-2-14)28(25,26)23-7-9-27-10-8-23/h1-6,12-13H,7-11H2,(H,20,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 6.80n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US10696692 (2020)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM449265
PNG
(N-[[4-[3-(4-methylpiperazine- 1-carbonyl)azetidin-...)
Show SMILES CN1CCN(CC1)C(=O)C1CN(C1)S(=O)(=O)c1ccc(CNC(=O)c2ccc3nccn3c2)cc1
Show InChI InChI=1S/C24H28N6O4S/c1-27-10-12-28(13-11-27)24(32)20-16-30(17-20)35(33,34)21-5-2-18(3-6-21)14-26-23(31)19-4-7-22-25-8-9-29(22)15-19/h2-9,15,20H,10-14,16-17H2,1H3,(H,26,31)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 7.03n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US10696692 (2020)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM449201
PNG
(Furo[2,3-c]pyridine-2- carboxylic acid 4-(1- isobu...)
Show SMILES CC(C)CN1CCC(CC1)S(=O)c1ccc(CNC(=O)c2cc3ccncc3o2)cc1
Show InChI InChI=1S/C24H29N3O3S/c1-17(2)16-27-11-8-21(9-12-27)31(29)20-5-3-18(4-6-20)14-26-24(28)22-13-19-7-10-25-15-23(19)30-22/h3-7,10,13,15,17,21H,8-9,11-12,14,16H2,1-2H3,(H,26,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PDB
UniChem
PDB
US Patent
n/an/a 7.23n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US10696692 (2020)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50439318
PNG
(CHEMBL2419536 | US10696692, Example 292)
Show SMILES O=C(NCc1ccc(cc1)S(=O)(=O)N1CCC(CC1)N1CCCC1)N1Cc2ccncc2C1
Show InChI InChI=1S/C24H31N5O3S/c30-24(28-17-20-7-10-25-16-21(20)18-28)26-15-19-3-5-23(6-4-19)33(31,32)29-13-8-22(9-14-29)27-11-1-2-12-27/h3-7,10,16,22H,1-2,8-9,11-15,17-18H2,(H,26,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 7.36n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US10696692 (2020)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM449051
PNG
(Imidazo[1,2-a]pyrimidine- 6-carboxylic acid 4-(4- ...)
Show SMILES OC1CCN(CC1)S(=O)(=O)c1ccc(CNC(=O)c2cnc3nccn3c2)cc1
Show InChI InChI=1S/C19H21N5O4S/c25-16-5-8-24(9-6-16)29(27,28)17-3-1-14(2-4-17)11-21-18(26)15-12-22-19-20-7-10-23(19)13-15/h1-4,7,10,12-13,16,25H,5-6,8-9,11H2,(H,21,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 7.5n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US10696692 (2020)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM449200
PNG
(Imidazo[1,2-a]pyrimidine- 6-carboxylic acid 4-(1- ...)
Show SMILES CC(C)CN1CCC(CC1)S(=O)c1ccc(CNC(=O)c2cnc3nccn3c2)cc1
Show InChI InChI=1S/C23H29N5O2S/c1-17(2)15-27-10-7-21(8-11-27)31(30)20-5-3-18(4-6-20)13-25-22(29)19-14-26-23-24-9-12-28(23)16-19/h3-6,9,12,14,16-17,21H,7-8,10-11,13,15H2,1-2H3,(H,25,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 7.60n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US10696692 (2020)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM449200
PNG
(Imidazo[1,2-a]pyrimidine- 6-carboxylic acid 4-(1- ...)
Show SMILES CC(C)CN1CCC(CC1)S(=O)c1ccc(CNC(=O)c2cnc3nccn3c2)cc1
Show InChI InChI=1S/C23H29N5O2S/c1-17(2)15-27-10-7-21(8-11-27)31(30)20-5-3-18(4-6-20)13-25-22(29)19-14-26-23-24-9-12-28(23)16-19/h3-6,9,12,14,16-17,21H,7-8,10-11,13,15H2,1-2H3,(H,25,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 7.70n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US10696692 (2020)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM449054
PNG
(Imidazo[1,2-a]pyrimidine- 6-carboxylic acid 4-(3- ...)
Show SMILES OC1CCCN(C1)S(=O)(=O)c1ccc(CNC(=O)c2cnc3nccn3c2)cc1
Show InChI InChI=1S/C19H21N5O4S/c25-16-2-1-8-24(13-16)29(27,28)17-5-3-14(4-6-17)10-21-18(26)15-11-22-19-20-7-9-23(19)12-15/h3-7,9,11-12,16,25H,1-2,8,10,13H2,(H,21,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 7.70n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US10696692 (2020)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM449077
PNG
(US10696692, Example 55 | [1-(4-{[(lmodazo[1,2- a]p...)
Show SMILES CC(C)(C)OC(=O)NC1CCN(CC1)S(=O)(=O)c1ccc(CNC(=O)c2ccc3nccn3c2)cc1
Show InChI InChI=1S/C25H31N5O5S/c1-25(2,3)35-24(32)28-20-10-13-30(14-11-20)36(33,34)21-7-4-18(5-8-21)16-27-23(31)19-6-9-22-26-12-15-29(22)17-19/h4-9,12,15,17,20H,10-11,13-14,16H2,1-3H3,(H,27,31)(H,28,32)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 7.70n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US10696692 (2020)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM449105
PNG
(Imidazo[1,2-a]pyridine-6- carboxylic acid 4- [(3R,...)
Show SMILES C[C@H]1CN(C[C@@H](C)N1CC(F)(F)F)S(=O)(=O)c1ccc(CNC(=O)c2ccc3nccn3c2)cc1
Show InChI InChI=1S/C23H26F3N5O3S/c1-16-12-30(13-17(2)31(16)15-23(24,25)26)35(33,34)20-6-3-18(4-7-20)11-28-22(32)19-5-8-21-27-9-10-29(21)14-19/h3-10,14,16-17H,11-13,15H2,1-2H3,(H,28,32)/t16-,17+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 7.70n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US10696692 (2020)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50060826
PNG
(CHEMBL3394721 | US10696692, Example 205)
Show SMILES O=C(NCc1ccc(cc1)S(=O)(=O)C1CCN(CC1)C1CCOCC1)c1cc2ccncc2o1
Show InChI InChI=1S/C25H29N3O5S/c29-25(23-15-19-5-10-26-17-24(19)33-23)27-16-18-1-3-21(4-2-18)34(30,31)22-6-11-28(12-7-22)20-8-13-32-14-9-20/h1-5,10,15,17,20,22H,6-9,11-14,16H2,(H,27,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 8n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US10696692 (2020)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM449185
PNG
(US10696692, Example 164 | cis-Imidazo[1,2- alpyrid...)
Show SMILES FC1CC2CC1CN2S(=O)(=O)c1ccc(CNC(=O)c2ccc3nccn3c2)cc1
Show InChI InChI=1S/C21H21FN4O3S/c22-19-10-17-9-16(19)13-26(17)30(28,29)18-4-1-14(2-5-18)11-24-21(27)15-3-6-20-23-7-8-25(20)12-15/h1-8,12,16-17,19H,9-11,13H2,(H,24,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 8.10n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US10696692 (2020)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM449238
PNG
(N-[[4-(1-oxa-7- azaspiro[4.4]nonan-7- ylsulfonyl)p...)
Show SMILES O=C(NCc1ccc(cc1)S(=O)(=O)N1CCC2(CCCO2)C1)c1ccc2nccn2c1
Show InChI InChI=1S/C22H24N4O4S/c27-21(18-4-7-20-23-10-12-25(20)15-18)24-14-17-2-5-19(6-3-17)31(28,29)26-11-9-22(16-26)8-1-13-30-22/h2-7,10,12,15H,1,8-9,11,13-14,16H2,(H,24,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 8.45n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US10696692 (2020)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM449043
PNG
(Imidazo[1,2-a]pyrimidine- 6-carboxylic acid 4- (te...)
Show SMILES O=C(NCc1ccc(cc1)S(=O)(=O)C1CCOCC1)c1cnc2nccn2c1
Show InChI InChI=1S/C19H20N4O4S/c24-18(15-12-22-19-20-7-8-23(19)13-15)21-11-14-1-3-16(4-2-14)28(25,26)17-5-9-27-10-6-17/h1-4,7-8,12-13,17H,5-6,9-11H2,(H,21,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 8.65n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US10696692 (2020)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM449043
PNG
(Imidazo[1,2-a]pyrimidine- 6-carboxylic acid 4- (te...)
Show SMILES O=C(NCc1ccc(cc1)S(=O)(=O)C1CCOCC1)c1cnc2nccn2c1
Show InChI InChI=1S/C19H20N4O4S/c24-18(15-12-22-19-20-7-8-23(19)13-15)21-11-14-1-3-16(4-2-14)28(25,26)17-5-9-27-10-6-17/h1-4,7-8,12-13,17H,5-6,9-11H2,(H,21,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 8.70n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US10696692 (2020)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM449286
PNG
(N-[[4-[(6,6-difluoro-2- azaspiro[3.3]heptan-2- yl)...)
Show SMILES FC1(F)CC2(CN(C2)S(=O)(=O)c2ccc(CNC(=O)c3ccc4nccn4c3)cc2)C1
Show InChI InChI=1S/C21H20F2N4O3S/c22-21(23)11-20(12-21)13-27(14-20)31(29,30)17-4-1-15(2-5-17)9-25-19(28)16-3-6-18-24-7-8-26(18)10-16/h1-8,10H,9,11-14H2,(H,25,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 8.77n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US10696692 (2020)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM449102
PNG
(Imidazo[1,2-a]pyrimidine- 6-carboxylic acid 4-[(R)...)
Show SMILES O=C(NCc1ccc(cc1)S(=O)(=O)[C@@H]1CCOC1)c1cnc2nccn2c1
Show InChI InChI=1S/C18H18N4O4S/c23-17(14-10-21-18-19-6-7-22(18)11-14)20-9-13-1-3-15(4-2-13)27(24,25)16-5-8-26-12-16/h1-4,6-7,10-11,16H,5,8-9,12H2,(H,20,23)/t16-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 8.88n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US10696692 (2020)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM449102
PNG
(Imidazo[1,2-a]pyrimidine- 6-carboxylic acid 4-[(R)...)
Show SMILES O=C(NCc1ccc(cc1)S(=O)(=O)[C@@H]1CCOC1)c1cnc2nccn2c1
Show InChI InChI=1S/C18H18N4O4S/c23-17(14-10-21-18-19-6-7-22(18)11-14)20-9-13-1-3-15(4-2-13)27(24,25)16-5-8-26-12-16/h1-4,6-7,10-11,16H,5,8-9,12H2,(H,20,23)/t16-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 8.90n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US10696692 (2020)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM449204
PNG
(8-(4-{[(Imidazo[1,2- a]pyridine-6-carbonyl)- amino...)
Show SMILES CC(C)(C)OC(=O)N1CCCC11CCCN(CC1)S(=O)(=O)c1ccc(CNC(=O)c2ccc3nccn3c2)cc1
Show InChI InChI=1S/C29H37N5O5S/c1-28(2,3)39-27(36)34-17-5-13-29(34)12-4-16-33(18-14-29)40(37,38)24-9-6-22(7-10-24)20-31-26(35)23-8-11-25-30-15-19-32(25)21-23/h6-11,15,19,21H,4-5,12-14,16-18,20H2,1-3H3,(H,31,35)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 8.99n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US10696692 (2020)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM449201
PNG
(Furo[2,3-c]pyridine-2- carboxylic acid 4-(1- isobu...)
Show SMILES CC(C)CN1CCC(CC1)S(=O)c1ccc(CNC(=O)c2cc3ccncc3o2)cc1
Show InChI InChI=1S/C24H29N3O3S/c1-17(2)16-27-11-8-21(9-12-27)31(29)20-5-3-18(4-6-20)14-26-24(28)22-13-19-7-10-25-15-23(19)30-22/h3-7,10,13,15,17,21H,8-9,11-12,14,16H2,1-2H3,(H,26,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PDB
UniChem
PDB
US Patent
n/an/a 9.30n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US10696692 (2020)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Displayed 1 to 50 (of 374 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%