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Patent code US10702504

Compile Data Set for Download or QSAR
Found 21 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transcription intermediary factor 1-alpha


(Homo sapiens (Human))
BDBM449307
PNG
(US10702504, Compound I-B4)
Show SMILES CCCOc1cc(OCCCCN(C)C)cc(Oc2cc3n(C)c(=O)n(C)c3cc2NS(=O)(=O)c2cccc(c2)C(=O)NCCOCCOCCOCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCc2ccc(cc2)-c2scnc2C)C(C)(C)C)c1
Show InChI InChI=1S/C61H81N9O14S2/c1-10-22-82-45-31-46(83-23-12-11-21-67(6)7)33-47(32-45)84-53-35-51-50(68(8)60(76)69(51)9)34-49(53)66-86(77,78)48-15-13-14-43(29-48)57(73)62-20-24-79-25-26-80-27-28-81-38-54(72)65-56(61(3,4)5)59(75)70-37-44(71)30-52(70)58(74)63-36-41-16-18-42(19-17-41)55-40(2)64-39-85-55/h13-19,29,31-35,39,44,52,56,66,71H,10-12,20-28,30,36-38H2,1-9H3,(H,62,73)(H,63,74)(H,65,72)/t44-,52+,56-/m1/s1
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n/an/a<10n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.

US Patent


Assay Description
The alpha assay was used to assess the binding of the compounds of the application to TRIM24 at various concentrations. All compounds were added at c...


US Patent US10702504 (2020)

More data for this
Ligand-Target Pair
Transcription intermediary factor 1-alpha


(Homo sapiens (Human))
BDBM449294
PNG
(US10702504, Compound I-A11)
Show SMILES CCCOc1cc(OCCCCN(C)C)cc(Oc2cc3n(C)c(=O)n(C)c3cc2NS(=O)(=O)c2cccc(c2)C(=O)NCCCCCCCCNC(=O)COc2cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c23)c1
Show InChI InChI=1S/C54H66N8O13S/c1-6-26-72-36-29-37(73-27-14-13-25-59(2)3)31-38(30-36)75-46-33-44-43(60(4)54(69)61(44)5)32-41(46)58-76(70,71)39-18-15-17-35(28-39)50(65)56-24-12-10-8-7-9-11-23-55-48(64)34-74-45-20-16-19-40-49(45)53(68)62(52(40)67)42-21-22-47(63)57-51(42)66/h15-20,28-33,42,58H,6-14,21-27,34H2,1-5H3,(H,55,64)(H,56,65)(H,57,63,66)
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n/an/a<10n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.

US Patent


Assay Description
The alpha assay was used to assess the binding of the compounds of the application to TRIM24 at various concentrations. All compounds were added at c...


US Patent US10702504 (2020)

More data for this
Ligand-Target Pair
Transcription intermediary factor 1-alpha


(Homo sapiens (Human))
BDBM449269
PNG
(US10702504, Compound I-A6)
Show SMILES CCCOc1cccc(Oc2cc3n(C)c(=O)n(C)c3cc2NS(=O)(=O)c2cccc(c2)C(=O)NCCCOCCOCCOCCCNC(=O)COc2cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c23)c1
Show InChI InChI=1S/C50H57N7O15S/c1-4-20-70-33-11-6-12-34(28-33)72-42-30-40-39(55(2)50(64)56(40)3)29-37(42)54-73(65,66)35-13-5-10-32(27-35)46(60)52-19-9-22-68-24-26-69-25-23-67-21-8-18-51-44(59)31-71-41-15-7-14-36-45(41)49(63)57(48(36)62)38-16-17-43(58)53-47(38)61/h5-7,10-15,27-30,38,54H,4,8-9,16-26,31H2,1-3H3,(H,51,59)(H,52,60)(H,53,58,61)
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n/an/a<10n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.

US Patent


Assay Description
The alpha assay was used to assess the binding of the compounds of the application to TRIM24 at various concentrations. All compounds were added at c...


US Patent US10702504 (2020)

More data for this
Ligand-Target Pair
Transcription intermediary factor 1-alpha


(Homo sapiens (Human))
BDBM449304
PNG
(US10702504, Compound I-B2)
Show SMILES CCCOc1cccc(Oc2cc3n(C)c(=O)n(C)c3cc2NS(=O)(=O)c2cccc(c2)C(=O)NCCOCCOCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCc2ccc(cc2)-c2scnc2C)C(C)(C)C)c1
Show InChI InChI=1S/C53H64N8O12S2/c1-8-20-72-38-12-10-13-39(26-38)73-45-28-43-42(59(6)52(67)60(43)7)27-41(45)58-75(68,69)40-14-9-11-36(24-40)49(64)54-19-21-70-22-23-71-31-46(63)57-48(53(3,4)5)51(66)61-30-37(62)25-44(61)50(65)55-29-34-15-17-35(18-16-34)47-33(2)56-32-74-47/h9-18,24,26-28,32,37,44,48,58,62H,8,19-23,25,29-31H2,1-7H3,(H,54,64)(H,55,65)(H,57,63)/t37-,44+,48-/m1/s1
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n/an/a<10n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.

US Patent


Assay Description
The alpha assay was used to assess the binding of the compounds of the application to TRIM24 at various concentrations. All compounds were added at c...


US Patent US10702504 (2020)

More data for this
Ligand-Target Pair
Transcription intermediary factor 1-alpha


(Homo sapiens (Human))
BDBM449296
PNG
(US10702504, Compound I-A12)
Show SMILES CCCOc1cc(OCCCCN(C)C)cc(Oc2cc3n(C)c(=O)n(C)c3cc2NS(=O)(=O)c2cccc(c2)C(=O)NCCCOCCOCCOCCCNC(=O)COc2cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c23)c1
Show InChI InChI=1S/C56H70N8O16S/c1-6-22-77-38-31-39(78-25-8-7-21-61(2)3)33-40(32-38)80-48-35-46-45(62(4)56(71)63(46)5)34-43(48)60-81(72,73)41-14-9-13-37(30-41)52(67)58-20-12-24-75-27-29-76-28-26-74-23-11-19-57-50(66)36-79-47-16-10-15-42-51(47)55(70)64(54(42)69)44-17-18-49(65)59-53(44)68/h9-10,13-16,30-35,44,60H,6-8,11-12,17-29,36H2,1-5H3,(H,57,66)(H,58,67)(H,59,65,68)
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n/an/a<10n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.

US Patent


Assay Description
The alpha assay was used to assess the binding of the compounds of the application to TRIM24 at various concentrations. All compounds were added at c...


US Patent US10702504 (2020)

More data for this
Ligand-Target Pair
Transcription intermediary factor 1-alpha


(Homo sapiens (Human))
BDBM50150808
PNG
(CHEMBL3774507 | US10702504, Compound C)
Show SMILES CC(C)COc1cccc(Oc2cc3n(C)c(=O)n(C)c3cc2NS(=O)(=O)c2cn(C)c(C)n2)c1
Show InChI InChI=1S/C24H29N5O5S/c1-15(2)14-33-17-8-7-9-18(10-17)34-22-12-21-20(28(5)24(30)29(21)6)11-19(22)26-35(31,32)23-13-27(4)16(3)25-23/h7-13,15,26H,14H2,1-6H3
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n/an/a<10n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.

US Patent


Assay Description
The alpha assay was used to assess the binding of the compounds of the application to TRIM24 at various concentrations. All compounds were added at c...


US Patent US10702504 (2020)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Transcription intermediary factor 1-alpha


(Homo sapiens (Human))
BDBM449285
PNG
(US10702504, Compound I-A10)
Show SMILES CCCOc1cc(OCCCCN(C)C)cc(Oc2cc3n(C)c(=O)n(C)c3cc2NS(=O)(=O)c2cccc(c2)C(=O)NCCCCNC(=O)COc2cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c23)c1
Show InChI InChI=1S/C50H58N8O13S/c1-6-22-68-32-25-33(69-23-10-9-21-55(2)3)27-34(26-32)71-42-29-40-39(56(4)50(65)57(40)5)28-37(42)54-72(66,67)35-14-11-13-31(24-35)46(61)52-20-8-7-19-51-44(60)30-70-41-16-12-15-36-45(41)49(64)58(48(36)63)38-17-18-43(59)53-47(38)62/h11-16,24-29,38,54H,6-10,17-23,30H2,1-5H3,(H,51,60)(H,52,61)(H,53,59,62)
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n/an/a<10n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.

US Patent


Assay Description
The alpha assay was used to assess the binding of the compounds of the application to TRIM24 at various concentrations. All compounds were added at c...


US Patent US10702504 (2020)

More data for this
Ligand-Target Pair
Transcription intermediary factor 1-alpha


(Homo sapiens (Human))
BDBM50150812
PNG
(CHEMBL3775853 | US10702504, Compound D)
Show SMILES CCCOc1cccc(Oc2cc3n(C)c(=O)n(C)c3cc2NS(=O)(=O)c2ccc(OC)c(OC)c2)c1
Show InChI InChI=1S/C26H29N3O7S/c1-6-12-35-17-8-7-9-18(13-17)36-24-16-22-21(28(2)26(30)29(22)3)15-20(24)27-37(31,32)19-10-11-23(33-4)25(14-19)34-5/h7-11,13-16,27H,6,12H2,1-5H3
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n/an/a<10n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.

US Patent


Assay Description
The alpha assay was used to assess the binding of the compounds of the application to TRIM24 at various concentrations. All compounds were added at c...


US Patent US10702504 (2020)

More data for this
Ligand-Target Pair
Transcription intermediary factor 1-alpha


(Homo sapiens (Human))
BDBM449309
PNG
(US10702504, Compound B)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)Nc1cc2n(C)c(=O)n(C)c2cc1Cc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C31H31N3O6S/c1-33-27-17-23(16-21-10-12-24(13-11-21)40-20-22-8-6-5-7-9-22)26(19-28(27)34(2)31(33)35)32-41(36,37)25-14-15-29(38-3)30(18-25)39-4/h5-15,17-19,32H,16,20H2,1-4H3
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n/an/a 55n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.

US Patent


Assay Description
The alpha assay was used to assess the binding of the compounds of the application to TRIM24 at various concentrations. All compounds were added at c...


US Patent US10702504 (2020)

More data for this
Ligand-Target Pair
Transcription intermediary factor 1-alpha


(Homo sapiens (Human))
BDBM449305
PNG
(US10702504, Compound I-B3)
Show SMILES CCCOc1cccc(Oc2cc3n(C)c(=O)n(C)c3cc2NS(=O)(=O)c2cccc(c2)C(=O)NCCOCCOCCOCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCc2ccc(cc2)-c2scnc2C)C(C)(C)C)c1
Show InChI InChI=1S/C55H68N8O13S2/c1-8-20-75-40-12-10-13-41(28-40)76-47-30-45-44(61(6)54(69)62(45)7)29-43(47)60-78(70,71)42-14-9-11-38(26-42)51(66)56-19-21-72-22-23-73-24-25-74-33-48(65)59-50(55(3,4)5)53(68)63-32-39(64)27-46(63)52(67)57-31-36-15-17-37(18-16-36)49-35(2)58-34-77-49/h9-18,26,28-30,34,39,46,50,60,64H,8,19-25,27,31-33H2,1-7H3,(H,56,66)(H,57,67)(H,59,65)/t39-,46+,50-/m1/s1
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n/an/a 55n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.

US Patent


Assay Description
The alpha assay was used to assess the binding of the compounds of the application to TRIM24 at various concentrations. All compounds were added at c...


US Patent US10702504 (2020)

More data for this
Ligand-Target Pair
Transcription intermediary factor 1-alpha


(Homo sapiens (Human))
BDBM449224
PNG
(US10702504, Compound I-A4)
Show SMILES CCCOc1cccc(Oc2cc3n(C)c(=O)n(C)c3cc2NS(=O)(=O)c2cccc(c2)C(=O)NCCCCNC(=O)COc2cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c23)c1
Show InChI InChI=1S/C44H45N7O12S/c1-4-20-61-27-11-8-12-28(22-27)63-36-24-34-33(49(2)44(58)50(34)3)23-31(36)48-64(59,60)29-13-7-10-26(21-29)40(54)46-19-6-5-18-45-38(53)25-62-35-15-9-14-30-39(35)43(57)51(42(30)56)32-16-17-37(52)47-41(32)55/h7-15,21-24,32,48H,4-6,16-20,25H2,1-3H3,(H,45,53)(H,46,54)(H,47,52,55)
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n/an/a 55n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.

US Patent


Assay Description
The alpha assay was used to assess the binding of the compounds of the application to TRIM24 at various concentrations. All compounds were added at c...


US Patent US10702504 (2020)

More data for this
Ligand-Target Pair
Transcription intermediary factor 1-alpha


(Homo sapiens (Human))
BDBM449232
PNG
(US10702504, Compound I-A5)
Show SMILES CCCOc1cccc(Oc2cc3n(C)c(=O)n(C)c3cc2NS(=O)(=O)c2cccc(c2)C(=O)NCCCCCCCCNC(=O)COc2cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c23)c1
Show InChI InChI=1S/C48H53N7O12S/c1-4-24-65-31-15-12-16-32(26-31)67-40-28-38-37(53(2)48(62)54(38)3)27-35(40)52-68(63,64)33-17-11-14-30(25-33)44(58)50-23-10-8-6-5-7-9-22-49-42(57)29-66-39-19-13-18-34-43(39)47(61)55(46(34)60)36-20-21-41(56)51-45(36)59/h11-19,25-28,36,52H,4-10,20-24,29H2,1-3H3,(H,49,57)(H,50,58)(H,51,56,59)
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n/an/a 300n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.

US Patent


Assay Description
The alpha assay was used to assess the binding of the compounds of the application to TRIM24 at various concentrations. All compounds were added at c...


US Patent US10702504 (2020)

More data for this
Ligand-Target Pair
Transcription intermediary factor 1-alpha


(Homo sapiens (Human))
BDBM449322
PNG
(US10702504, Compound E)
Show SMILES CCCOc1cccc(Oc2cc3n(C)c(=O)n(C)c3cc2NS(=O)(=O)c2cccc(c2)C(=O)NCCCCNC(=O)CC23CC4CC(CC(C4)C2)C3)c1
Show InChI InChI=1S/C41H51N5O7S/c1-4-15-52-31-10-8-11-32(20-31)53-37-22-36-35(45(2)40(49)46(36)3)21-34(37)44-54(50,51)33-12-7-9-30(19-33)39(48)43-14-6-5-13-42-38(47)26-41-23-27-16-28(24-41)18-29(17-27)25-41/h7-12,19-22,27-29,44H,4-6,13-18,23-26H2,1-3H3,(H,42,47)(H,43,48)
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n/an/a 300n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.

US Patent


Assay Description
The alpha assay was used to assess the binding of the compounds of the application to TRIM24 at various concentrations. All compounds were added at c...


US Patent US10702504 (2020)

More data for this
Ligand-Target Pair
Transcription intermediary factor 1-alpha


(Homo sapiens (Human))
BDBM449303
PNG
(US10702504, Compound I-B1)
Show SMILES CCCOc1cccc(Oc2cc3n(C)c(=O)n(C)c3cc2NS(=O)(=O)c2cccc(c2)C(=O)NCCOCCOCCOc2cc(ccc2CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@H](C(C)C)N2Cc3ccccc3C2=O)-c2scnc2C)c1
Show InChI InChI=1S/C60H68N8O13S2/c1-7-21-79-44-14-11-15-45(30-44)81-53-32-50-49(65(5)60(74)66(50)6)31-48(53)64-83(75,76)46-16-10-13-40(27-46)56(70)61-20-22-77-23-24-78-25-26-80-52-28-39(55-38(4)63-36-82-55)18-19-41(52)33-62-57(71)51-29-43(69)35-67(51)59(73)54(37(2)3)68-34-42-12-8-9-17-47(42)58(68)72/h8-19,27-28,30-32,36-37,43,51,54,64,69H,7,20-26,29,33-35H2,1-6H3,(H,61,70)(H,62,71)/t43-,51+,54+/m1/s1
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n/an/a 300n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.

US Patent


Assay Description
The alpha assay was used to assess the binding of the compounds of the application to TRIM24 at various concentrations. All compounds were added at c...


US Patent US10702504 (2020)

More data for this
Ligand-Target Pair
Transcription intermediary factor 1-alpha


(Homo sapiens (Human))
BDBM449280
PNG
(US10702504, Compound I-A7)
Show SMILES Cc1nc(cn1C)S(=O)(=O)Nc1cc2n(C)c(=O)n(C)c2cc1Oc1cccc(OCC(=O)NCCCCNC(=O)COc2cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c23)c1
Show InChI InChI=1S/C41H43N9O12S/c1-23-44-36(20-47(23)2)63(58,59)46-27-18-29-30(49(4)41(57)48(29)3)19-32(27)62-25-10-7-9-24(17-25)60-21-34(52)42-15-5-6-16-43-35(53)22-61-31-12-8-11-26-37(31)40(56)50(39(26)55)28-13-14-33(51)45-38(28)54/h7-12,17-20,28,46H,5-6,13-16,21-22H2,1-4H3,(H,42,52)(H,43,53)(H,45,51,54)
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n/an/a 750n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.

US Patent


Assay Description
The alpha assay was used to assess the binding of the compounds of the application to TRIM24 at various concentrations. All compounds were added at c...


US Patent US10702504 (2020)

More data for this
Ligand-Target Pair
Transcription intermediary factor 1-alpha


(Homo sapiens (Human))
BDBM449284
PNG
(US10702504, Compound I-A9)
Show SMILES Cc1nc(cn1C)S(=O)(=O)Nc1cc2n(C)c(=O)n(C)c2cc1Oc1cccc(OCC(=O)NCCCOCCOCCOCCCNC(=O)COc2cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c23)c1
Show InChI InChI=1S/C47H55N9O15S/c1-29-50-42(26-53(29)2)72(64,65)52-33-24-35-36(55(4)47(63)54(35)3)25-38(33)71-31-10-5-9-30(23-31)69-27-40(58)48-15-7-17-66-19-21-68-22-20-67-18-8-16-49-41(59)28-70-37-12-6-11-32-43(37)46(62)56(45(32)61)34-13-14-39(57)51-44(34)60/h5-6,9-12,23-26,34,52H,7-8,13-22,27-28H2,1-4H3,(H,48,58)(H,49,59)(H,51,57,60)
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n/an/a 750n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.

US Patent


Assay Description
The alpha assay was used to assess the binding of the compounds of the application to TRIM24 at various concentrations. All compounds were added at c...


US Patent US10702504 (2020)

More data for this
Ligand-Target Pair
Transcription intermediary factor 1-alpha


(Homo sapiens (Human))
BDBM449215
PNG
(US10702504, Compound I-A1)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)Nc1cc2n(C)c(=O)n(C)c2cc1Oc1ccc(OCC(=O)NCCCCNC(=O)COc2cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c23)cc1
Show InChI InChI=1S/C44H45N7O14S/c1-49-31-21-29(48-66(59,60)27-14-16-33(61-3)36(20-27)62-4)35(22-32(31)50(2)44(49)58)65-26-12-10-25(11-13-26)63-23-38(53)45-18-5-6-19-46-39(54)24-64-34-9-7-8-28-40(34)43(57)51(42(28)56)30-15-17-37(52)47-41(30)55/h7-14,16,20-22,30,48H,5-6,15,17-19,23-24H2,1-4H3,(H,45,53)(H,46,54)(H,47,52,55)
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n/an/a 750n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.

US Patent


Assay Description
The alpha assay was used to assess the binding of the compounds of the application to TRIM24 at various concentrations. All compounds were added at c...


US Patent US10702504 (2020)

More data for this
Ligand-Target Pair
Transcription intermediary factor 1-alpha


(Homo sapiens (Human))
BDBM449220
PNG
(US10702504, Compound I-A2)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)Nc1cc2n(C)c(=O)n(C)c2cc1Oc1ccc(OCC(=O)NCCCCCCCCNC(=O)COc2cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c23)cc1
Show InChI InChI=1S/C48H53N7O14S/c1-53-35-25-33(52-70(63,64)31-18-20-37(65-3)40(24-31)66-4)39(26-36(35)54(2)48(53)62)69-30-16-14-29(15-17-30)67-27-42(57)49-22-9-7-5-6-8-10-23-50-43(58)28-68-38-13-11-12-32-44(38)47(61)55(46(32)60)34-19-21-41(56)51-45(34)59/h11-18,20,24-26,34,52H,5-10,19,21-23,27-28H2,1-4H3,(H,49,57)(H,50,58)(H,51,56,59)
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n/an/a 750n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.

US Patent


Assay Description
The alpha assay was used to assess the binding of the compounds of the application to TRIM24 at various concentrations. All compounds were added at c...


US Patent US10702504 (2020)

More data for this
Ligand-Target Pair
Transcription intermediary factor 1-alpha


(Homo sapiens (Human))
BDBM449281
PNG
(US10702504, Compound I-A8)
Show SMILES Cc1nc(cn1C)S(=O)(=O)Nc1cc2n(C)c(=O)n(C)c2cc1Oc1cccc(OCC(=O)NCCCCCCCCNC(=O)COc2cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c23)c1
Show InChI InChI=1S/C45H51N9O12S/c1-27-48-40(24-51(27)2)67(62,63)50-31-22-33-34(53(4)45(61)52(33)3)23-36(31)66-29-14-11-13-28(21-29)64-25-38(56)46-19-9-7-5-6-8-10-20-47-39(57)26-65-35-16-12-15-30-41(35)44(60)54(43(30)59)32-17-18-37(55)49-42(32)58/h11-16,21-24,32,50H,5-10,17-20,25-26H2,1-4H3,(H,46,56)(H,47,57)(H,49,55,58)
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n/an/a 750n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.

US Patent


Assay Description
The alpha assay was used to assess the binding of the compounds of the application to TRIM24 at various concentrations. All compounds were added at c...


US Patent US10702504 (2020)

More data for this
Ligand-Target Pair
Transcription intermediary factor 1-alpha


(Homo sapiens (Human))
BDBM449221
PNG
(US10702504, Compound I-A3)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)Nc1cc2n(C)c(=O)n(C)c2cc1Oc1ccc(OCC(=O)NCCCOCCOCCOCCCNC(=O)COc2cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c23)cc1
Show InChI InChI=1S/C50H57N7O17S/c1-55-37-27-35(54-75(65,66)33-14-16-39(67-3)42(26-33)68-4)41(28-38(37)56(2)50(55)64)74-32-12-10-31(11-13-32)72-29-44(59)51-18-6-20-69-22-24-71-25-23-70-21-7-19-52-45(60)30-73-40-9-5-8-34-46(40)49(63)57(48(34)62)36-15-17-43(58)53-47(36)61/h5,8-14,16,26-28,36,54H,6-7,15,17-25,29-30H2,1-4H3,(H,51,59)(H,52,60)(H,53,58,61)
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n/an/a 750n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.

US Patent


Assay Description
The alpha assay was used to assess the binding of the compounds of the application to TRIM24 at various concentrations. All compounds were added at c...


US Patent US10702504 (2020)

More data for this
Ligand-Target Pair
Transcription intermediary factor 1-alpha


(Homo sapiens (Human))
BDBM50148478
PNG
(CHEMBL3769965 | US10702504, Compound A)
Show SMILES COc1ccc(Oc2cc3n(C)c(=O)n(C)c3cc2NS(=O)(=O)c2ccc(OC)c(OC)c2)cc1
Show InChI InChI=1S/C24H25N3O7S/c1-26-19-13-18(25-35(29,30)17-10-11-21(32-4)23(12-17)33-5)22(14-20(19)27(2)24(26)28)34-16-8-6-15(31-3)7-9-16/h6-14,25H,1-5H3
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n/an/a 750n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.

US Patent


Assay Description
The alpha assay was used to assess the binding of the compounds of the application to TRIM24 at various concentrations. All compounds were added at c...


US Patent US10702504 (2020)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
* indicates data uncertainty>20%