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Patent code US10703751

Compile Data Set for Download or QSAR
Found 36 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM449876
PNG
(US10703751, Example 2 | US10703751, Example 3 | tr...)
Show SMILES CNc1cc2n([C@H]3CC[C@H](CC#N)CC3)c(nc2cn1)[C@@H](C)O
Show InChI InChI=1S/C17H23N5O/c1-11(23)17-21-14-10-20-16(19-2)9-15(14)22(17)13-5-3-12(4-6-13)7-8-18/h9-13,23H,3-7H2,1-2H3,(H,19,20)/t11-,12-,13-/m1/s1
PDB

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n/an/an/an/a 1.13E+3n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...


US Patent US10703751 (2020)

More data for this
Ligand-Target Pair
TYK2 (aa 871-1187)


(Homo sapiens (Human))
BDBM449883
PNG
(US10703751, Example 641 of WO2011086053)
Show SMILES C[C@H](O)c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1
PDB

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US Patent
n/an/an/an/a 115n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...


US Patent US10703751 (2020)

More data for this
Ligand-Target Pair
TYK2 (aa 871-1187)


(Homo sapiens (Human))
BDBM449878
PNG
(US10703751, Example 4 | trans-2-[4-[2-[(1R)-1-Hydr...)
Show SMILES CNc1cc2n([C@H]3CC[C@H](CC#N)CC3)c(nc2cn1)[C@@H](C)O
Show InChI InChI=1S/C17H23N5O/c1-11(23)17-21-14-10-20-16(19-2)9-15(14)22(17)13-5-3-12(4-6-13)7-8-18/h9-13,23H,3-7H2,1-2H3,(H,19,20)/t11-,12-,13-/m1/s1
PDB

GoogleScholar
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US Patent
n/an/an/an/a 43n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...


US Patent US10703751 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 850-1154)


(Homo sapiens (Human))
BDBM449880
PNG
(US10703751, Example 6 | cis-2-[4-[2-[1-Hydroxyethy...)
Show SMILES CNc1cc2n([C@@H]3CC[C@H](CC#N)CC3)c(nc2cn1)C(C)O
Show InChI InChI=1S/C17H23N5O/c1-11(23)17-21-14-10-20-16(19-2)9-15(14)22(17)13-5-3-12(4-6-13)7-8-18/h9-13,23H,3-7H2,1-2H3,(H,19,20)/t11?,12-,13+
PDB

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UniChem
US Patent
n/an/an/an/a 508n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...


US Patent US10703751 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM449875
PNG
(US10703751, Example 1 | US10703751, Example 5 | tr...)
Show SMILES CNc1cc2n([C@H]3CC[C@H](CC#N)CC3)c(nc2cn1)C(C)O
Show InChI InChI=1S/C17H23N5O/c1-11(23)17-21-14-10-20-16(19-2)9-15(14)22(17)13-5-3-12(4-6-13)7-8-18/h9-13,23H,3-7H2,1-2H3,(H,19,20)/t11?,12-,13-
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n/an/an/an/a 301n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...


US Patent US10703751 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM449875
PNG
(US10703751, Example 1 | US10703751, Example 5 | tr...)
Show SMILES CNc1cc2n([C@H]3CC[C@H](CC#N)CC3)c(nc2cn1)C(C)O
Show InChI InChI=1S/C17H23N5O/c1-11(23)17-21-14-10-20-16(19-2)9-15(14)22(17)13-5-3-12(4-6-13)7-8-18/h9-13,23H,3-7H2,1-2H3,(H,19,20)/t11?,12-,13-
PDB

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n/an/an/an/a 3.20E+3n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...


US Patent US10703751 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 850-1154)


(Homo sapiens (Human))
BDBM449881
PNG
(US10703751, Example 7 | cis-2-[4-[2-[(1R)-1-Hydrox...)
Show SMILES CNc1cc2n([C@@H]3CC[C@H](CC#N)CC3)c(nc2cn1)[C@@H](C)O
Show InChI InChI=1S/C17H23N5O/c1-11(23)17-21-14-10-20-16(19-2)9-15(14)22(17)13-5-3-12(4-6-13)7-8-18/h9-13,23H,3-7H2,1-2H3,(H,19,20)/t11-,12-,13+/m1/s1
PDB

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UniChem
US Patent
n/an/an/an/a 129n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...


US Patent US10703751 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50434787
PNG
(CHEMBL2386635 | US10487083, Example C | US10703751...)
Show SMILES C[C@@H](O)c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1
Show InChI InChI=1S/C18H21N5O/c1-11(24)18-22-15-10-21-17-14(7-9-20-17)16(15)23(18)13-4-2-12(3-5-13)6-8-19/h7,9-13,24H,2-6H2,1H3,(H,20,21)/t11-,12-,13-/m1/s1
PDB

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n/an/an/an/a 3.34n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...


US Patent US10703751 (2020)

More data for this
Ligand-Target Pair
TYK2 (aa 871-1187)


(Homo sapiens (Human))
BDBM449875
PNG
(US10703751, Example 1 | US10703751, Example 5 | tr...)
Show SMILES CNc1cc2n([C@H]3CC[C@H](CC#N)CC3)c(nc2cn1)C(C)O
Show InChI InChI=1S/C17H23N5O/c1-11(23)17-21-14-10-20-16(19-2)9-15(14)22(17)13-5-3-12(4-6-13)7-8-18/h9-13,23H,3-7H2,1-2H3,(H,19,20)/t11?,12-,13-
PDB

GoogleScholar
UniChem
US Patent
n/an/an/an/a 111n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...


US Patent US10703751 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 850-1154)


(Homo sapiens (Human))
BDBM449876
PNG
(US10703751, Example 2 | US10703751, Example 3 | tr...)
Show SMILES CNc1cc2n([C@H]3CC[C@H](CC#N)CC3)c(nc2cn1)[C@@H](C)O
Show InChI InChI=1S/C17H23N5O/c1-11(23)17-21-14-10-20-16(19-2)9-15(14)22(17)13-5-3-12(4-6-13)7-8-18/h9-13,23H,3-7H2,1-2H3,(H,19,20)/t11-,12-,13-/m1/s1
PDB

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US Patent
n/an/an/an/a 44.4n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...


US Patent US10703751 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 850-1154)


(Homo sapiens (Human))
BDBM449883
PNG
(US10703751, Example 641 of WO2011086053)
Show SMILES C[C@H](O)c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1
PDB

GoogleScholar
UniChem
US Patent
n/an/an/an/a 6.81n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...


US Patent US10703751 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM449883
PNG
(US10703751, Example 641 of WO2011086053)
Show SMILES C[C@H](O)c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1
PDB

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n/an/an/an/a 228n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...


US Patent US10703751 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM449875
PNG
(US10703751, Example 1 | US10703751, Example 5 | tr...)
Show SMILES CNc1cc2n([C@H]3CC[C@H](CC#N)CC3)c(nc2cn1)C(C)O
Show InChI InChI=1S/C17H23N5O/c1-11(23)17-21-14-10-20-16(19-2)9-15(14)22(17)13-5-3-12(4-6-13)7-8-18/h9-13,23H,3-7H2,1-2H3,(H,19,20)/t11?,12-,13-
PDB

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n/an/an/an/a 5.26E+3n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...


US Patent US10703751 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM449876
PNG
(US10703751, Example 2 | US10703751, Example 3 | tr...)
Show SMILES CNc1cc2n([C@H]3CC[C@H](CC#N)CC3)c(nc2cn1)[C@@H](C)O
Show InChI InChI=1S/C17H23N5O/c1-11(23)17-21-14-10-20-16(19-2)9-15(14)22(17)13-5-3-12(4-6-13)7-8-18/h9-13,23H,3-7H2,1-2H3,(H,19,20)/t11-,12-,13-/m1/s1
PDB

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n/an/an/an/a 9.82E+3n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...


US Patent US10703751 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM449878
PNG
(US10703751, Example 4 | trans-2-[4-[2-[(1R)-1-Hydr...)
Show SMILES CNc1cc2n([C@H]3CC[C@H](CC#N)CC3)c(nc2cn1)[C@@H](C)O
Show InChI InChI=1S/C17H23N5O/c1-11(23)17-21-14-10-20-16(19-2)9-15(14)22(17)13-5-3-12(4-6-13)7-8-18/h9-13,23H,3-7H2,1-2H3,(H,19,20)/t11-,12-,13-/m1/s1
PDB

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n/an/an/an/a 2.31E+3n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...


US Patent US10703751 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM449881
PNG
(US10703751, Example 7 | cis-2-[4-[2-[(1R)-1-Hydrox...)
Show SMILES CNc1cc2n([C@@H]3CC[C@H](CC#N)CC3)c(nc2cn1)[C@@H](C)O
Show InChI InChI=1S/C17H23N5O/c1-11(23)17-21-14-10-20-16(19-2)9-15(14)22(17)13-5-3-12(4-6-13)7-8-18/h9-13,23H,3-7H2,1-2H3,(H,19,20)/t11-,12-,13+/m1/s1
PDB

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n/an/an/an/a 981n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...


US Patent US10703751 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 850-1154)


(Homo sapiens (Human))
BDBM449876
PNG
(US10703751, Example 2 | US10703751, Example 3 | tr...)
Show SMILES CNc1cc2n([C@H]3CC[C@H](CC#N)CC3)c(nc2cn1)[C@@H](C)O
Show InChI InChI=1S/C17H23N5O/c1-11(23)17-21-14-10-20-16(19-2)9-15(14)22(17)13-5-3-12(4-6-13)7-8-18/h9-13,23H,3-7H2,1-2H3,(H,19,20)/t11-,12-,13-/m1/s1
PDB

GoogleScholar
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US Patent
n/an/an/an/a 3.48n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...


US Patent US10703751 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM449876
PNG
(US10703751, Example 2 | US10703751, Example 3 | tr...)
Show SMILES CNc1cc2n([C@H]3CC[C@H](CC#N)CC3)c(nc2cn1)[C@@H](C)O
Show InChI InChI=1S/C17H23N5O/c1-11(23)17-21-14-10-20-16(19-2)9-15(14)22(17)13-5-3-12(4-6-13)7-8-18/h9-13,23H,3-7H2,1-2H3,(H,19,20)/t11-,12-,13-/m1/s1
PDB

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n/an/an/an/a 1.70E+3n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...


US Patent US10703751 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM449881
PNG
(US10703751, Example 7 | cis-2-[4-[2-[(1R)-1-Hydrox...)
Show SMILES CNc1cc2n([C@@H]3CC[C@H](CC#N)CC3)c(nc2cn1)[C@@H](C)O
Show InChI InChI=1S/C17H23N5O/c1-11(23)17-21-14-10-20-16(19-2)9-15(14)22(17)13-5-3-12(4-6-13)7-8-18/h9-13,23H,3-7H2,1-2H3,(H,19,20)/t11-,12-,13+/m1/s1
PDB

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n/an/an/an/a 1.01E+3n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...


US Patent US10703751 (2020)

More data for this
Ligand-Target Pair
TYK2 (aa 871-1187)


(Homo sapiens (Human))
BDBM449881
PNG
(US10703751, Example 7 | cis-2-[4-[2-[(1R)-1-Hydrox...)
Show SMILES CNc1cc2n([C@@H]3CC[C@H](CC#N)CC3)c(nc2cn1)[C@@H](C)O
Show InChI InChI=1S/C17H23N5O/c1-11(23)17-21-14-10-20-16(19-2)9-15(14)22(17)13-5-3-12(4-6-13)7-8-18/h9-13,23H,3-7H2,1-2H3,(H,19,20)/t11-,12-,13+/m1/s1
PDB

GoogleScholar
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US Patent
n/an/an/an/a 443n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...


US Patent US10703751 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 850-1154)


(Homo sapiens (Human))
BDBM50434787
PNG
(CHEMBL2386635 | US10487083, Example C | US10703751...)
Show SMILES C[C@@H](O)c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1
Show InChI InChI=1S/C18H21N5O/c1-11(24)18-22-15-10-21-17-14(7-9-20-17)16(15)23(18)13-4-2-12(3-5-13)6-8-19/h7,9-13,24H,2-6H2,1H3,(H,20,21)/t11-,12-,13-/m1/s1
PDB

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PC cid
PC sid
PDB
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PDB
US Patent
n/an/an/an/a 0.340n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...


US Patent US10703751 (2020)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
TYK2 (aa 871-1187)


(Homo sapiens (Human))
BDBM50434787
PNG
(CHEMBL2386635 | US10487083, Example C | US10703751...)
Show SMILES C[C@@H](O)c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1
Show InChI InChI=1S/C18H21N5O/c1-11(24)18-22-15-10-21-17-14(7-9-20-17)16(15)23(18)13-4-2-12(3-5-13)6-8-19/h7,9-13,24H,2-6H2,1H3,(H,20,21)/t11-,12-,13-/m1/s1
PDB

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PC cid
PC sid
PDB
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US Patent
n/an/an/an/a 3.32n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...


US Patent US10703751 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM449883
PNG
(US10703751, Example 641 of WO2011086053)
Show SMILES C[C@H](O)c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1
PDB

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n/an/an/an/a 739n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...


US Patent US10703751 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM449875
PNG
(US10703751, Example 1 | US10703751, Example 5 | tr...)
Show SMILES CNc1cc2n([C@H]3CC[C@H](CC#N)CC3)c(nc2cn1)C(C)O
Show InChI InChI=1S/C17H23N5O/c1-11(23)17-21-14-10-20-16(19-2)9-15(14)22(17)13-5-3-12(4-6-13)7-8-18/h9-13,23H,3-7H2,1-2H3,(H,19,20)/t11?,12-,13-
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n/an/an/an/a 530n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...


US Patent US10703751 (2020)

More data for this
Ligand-Target Pair
TYK2 (aa 871-1187)


(Homo sapiens (Human))
BDBM449876
PNG
(US10703751, Example 2 | US10703751, Example 3 | tr...)
Show SMILES CNc1cc2n([C@H]3CC[C@H](CC#N)CC3)c(nc2cn1)[C@@H](C)O
Show InChI InChI=1S/C17H23N5O/c1-11(23)17-21-14-10-20-16(19-2)9-15(14)22(17)13-5-3-12(4-6-13)7-8-18/h9-13,23H,3-7H2,1-2H3,(H,19,20)/t11-,12-,13-/m1/s1
PDB

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n/an/an/an/a 466n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...


US Patent US10703751 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM449876
PNG
(US10703751, Example 2 | US10703751, Example 3 | tr...)
Show SMILES CNc1cc2n([C@H]3CC[C@H](CC#N)CC3)c(nc2cn1)[C@@H](C)O
Show InChI InChI=1S/C17H23N5O/c1-11(23)17-21-14-10-20-16(19-2)9-15(14)22(17)13-5-3-12(4-6-13)7-8-18/h9-13,23H,3-7H2,1-2H3,(H,19,20)/t11-,12-,13-/m1/s1
PDB

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n/an/an/an/a 171n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...


US Patent US10703751 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 850-1154)


(Homo sapiens (Human))
BDBM449878
PNG
(US10703751, Example 4 | trans-2-[4-[2-[(1R)-1-Hydr...)
Show SMILES CNc1cc2n([C@H]3CC[C@H](CC#N)CC3)c(nc2cn1)[C@@H](C)O
Show InChI InChI=1S/C17H23N5O/c1-11(23)17-21-14-10-20-16(19-2)9-15(14)22(17)13-5-3-12(4-6-13)7-8-18/h9-13,23H,3-7H2,1-2H3,(H,19,20)/t11-,12-,13-/m1/s1
PDB

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US Patent
n/an/an/an/a 3.46n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...


US Patent US10703751 (2020)

More data for this
Ligand-Target Pair
TYK2 (aa 871-1187)


(Homo sapiens (Human))
BDBM449875
PNG
(US10703751, Example 1 | US10703751, Example 5 | tr...)
Show SMILES CNc1cc2n([C@H]3CC[C@H](CC#N)CC3)c(nc2cn1)C(C)O
Show InChI InChI=1S/C17H23N5O/c1-11(23)17-21-14-10-20-16(19-2)9-15(14)22(17)13-5-3-12(4-6-13)7-8-18/h9-13,23H,3-7H2,1-2H3,(H,19,20)/t11?,12-,13-
PDB

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UniChem
US Patent
n/an/an/an/a 102n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...


US Patent US10703751 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 850-1154)


(Homo sapiens (Human))
BDBM449875
PNG
(US10703751, Example 1 | US10703751, Example 5 | tr...)
Show SMILES CNc1cc2n([C@H]3CC[C@H](CC#N)CC3)c(nc2cn1)C(C)O
Show InChI InChI=1S/C17H23N5O/c1-11(23)17-21-14-10-20-16(19-2)9-15(14)22(17)13-5-3-12(4-6-13)7-8-18/h9-13,23H,3-7H2,1-2H3,(H,19,20)/t11?,12-,13-
PDB

GoogleScholar
UniChem
US Patent
n/an/an/an/a 10.8n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...


US Patent US10703751 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM449878
PNG
(US10703751, Example 4 | trans-2-[4-[2-[(1R)-1-Hydr...)
Show SMILES CNc1cc2n([C@H]3CC[C@H](CC#N)CC3)c(nc2cn1)[C@@H](C)O
Show InChI InChI=1S/C17H23N5O/c1-11(23)17-21-14-10-20-16(19-2)9-15(14)22(17)13-5-3-12(4-6-13)7-8-18/h9-13,23H,3-7H2,1-2H3,(H,19,20)/t11-,12-,13-/m1/s1
PDB

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n/an/an/an/a 153n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...


US Patent US10703751 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 850-1154)


(Homo sapiens (Human))
BDBM449875
PNG
(US10703751, Example 1 | US10703751, Example 5 | tr...)
Show SMILES CNc1cc2n([C@H]3CC[C@H](CC#N)CC3)c(nc2cn1)C(C)O
Show InChI InChI=1S/C17H23N5O/c1-11(23)17-21-14-10-20-16(19-2)9-15(14)22(17)13-5-3-12(4-6-13)7-8-18/h9-13,23H,3-7H2,1-2H3,(H,19,20)/t11?,12-,13-
PDB

GoogleScholar
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US Patent
n/an/an/an/a 8.41n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...


US Patent US10703751 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM449880
PNG
(US10703751, Example 6 | cis-2-[4-[2-[1-Hydroxyethy...)
Show SMILES CNc1cc2n([C@@H]3CC[C@H](CC#N)CC3)c(nc2cn1)C(C)O
Show InChI InChI=1S/C17H23N5O/c1-11(23)17-21-14-10-20-16(19-2)9-15(14)22(17)13-5-3-12(4-6-13)7-8-18/h9-13,23H,3-7H2,1-2H3,(H,19,20)/t11?,12-,13+
PDB

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n/an/an/an/a 2.64E+3n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...


US Patent US10703751 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM449880
PNG
(US10703751, Example 6 | cis-2-[4-[2-[1-Hydroxyethy...)
Show SMILES CNc1cc2n([C@@H]3CC[C@H](CC#N)CC3)c(nc2cn1)C(C)O
Show InChI InChI=1S/C17H23N5O/c1-11(23)17-21-14-10-20-16(19-2)9-15(14)22(17)13-5-3-12(4-6-13)7-8-18/h9-13,23H,3-7H2,1-2H3,(H,19,20)/t11?,12-,13+
PDB

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n/an/an/an/a 2.87E+3n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...


US Patent US10703751 (2020)

More data for this
Ligand-Target Pair
TYK2 (aa 871-1187)


(Homo sapiens (Human))
BDBM449880
PNG
(US10703751, Example 6 | cis-2-[4-[2-[1-Hydroxyethy...)
Show SMILES CNc1cc2n([C@@H]3CC[C@H](CC#N)CC3)c(nc2cn1)C(C)O
Show InChI InChI=1S/C17H23N5O/c1-11(23)17-21-14-10-20-16(19-2)9-15(14)22(17)13-5-3-12(4-6-13)7-8-18/h9-13,23H,3-7H2,1-2H3,(H,19,20)/t11?,12-,13+
PDB

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US Patent
n/an/an/an/a 1.11E+3n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...


US Patent US10703751 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50434787
PNG
(CHEMBL2386635 | US10487083, Example C | US10703751...)
Show SMILES C[C@@H](O)c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1
Show InChI InChI=1S/C18H21N5O/c1-11(24)18-22-15-10-21-17-14(7-9-20-17)16(15)23(18)13-4-2-12(3-5-13)6-8-19/h7,9-13,24H,2-6H2,1H3,(H,20,21)/t11-,12-,13-/m1/s1
PDB

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Similars

US Patent
n/an/an/an/a 13.1n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...


US Patent US10703751 (2020)

More data for this
Ligand-Target Pair
TYK2 (aa 871-1187)


(Homo sapiens (Human))
BDBM449876
PNG
(US10703751, Example 2 | US10703751, Example 3 | tr...)
Show SMILES CNc1cc2n([C@H]3CC[C@H](CC#N)CC3)c(nc2cn1)[C@@H](C)O
Show InChI InChI=1S/C17H23N5O/c1-11(23)17-21-14-10-20-16(19-2)9-15(14)22(17)13-5-3-12(4-6-13)7-8-18/h9-13,23H,3-7H2,1-2H3,(H,19,20)/t11-,12-,13-/m1/s1
PDB

GoogleScholar
UniChem
US Patent
n/an/an/an/a 32n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...


US Patent US10703751 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%