Affinity Data by Patent

Patent code US10708263

Found 5 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
JAK1 (aa 850-1154) (Homo sapiens (Human))	BDBM103727 (US10112907, Example 00033 \| US10206907, Compound 2...) Show SMILES Show InChI	PDB GoogleScholar	Purchase PC cid PC sid PDB UniChem Similars	US Patent	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description JAK1 (IC50): Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) is purchased from Carna Biosciences. 10 ng of JAK1...				US Patent US10708263 (2020)
GALAPAGOS NV US Patent					More data for this Ligand-Target Pair
JAK2 (aa 808-1132) (Homo sapiens (Human))	BDBM103727 (US10112907, Example 00033 \| US10206907, Compound 2...) Show SMILES Show InChI	PDB GoogleScholar	Purchase PC cid PC sid PDB UniChem Similars	PDB US Patent	n/a	n/a	74	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description JAK1 (KI): For the determination of Ki, different amounts of compound are mixed with the enzyme and the enzymatic reaction is followed as a function ...				US Patent US10708263 (2020)
GALAPAGOS NV US Patent					More data for this Ligand-Target Pair				3D Structure (crystal)
TYK2 (aa 871-1187) (Homo sapiens (Human))	BDBM103727 (US10112907, Example 00033 \| US10206907, Compound 2...) Show SMILES Show InChI	PDB GoogleScholar	Purchase PC cid PC sid PDB UniChem Similars	US Patent	n/a	n/a	78	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description JAK2 (Kd): JAK2 (Invitrogen, PV4210) is used at a final concentration of 5 nM. The binding experiment is performed in 50 mM Hepes pH 7.5, 0.01% Brij-...				US Patent US10708263 (2020)
GALAPAGOS NV US Patent					More data for this Ligand-Target Pair
JAK3 (aa 781-1124) (Homo sapiens (Human))	BDBM103727 (US10112907, Example 00033 \| US10206907, Compound 2...) Show SMILES Show InChI	PDB GoogleScholar	Purchase PC cid PC sid PDB UniChem Similars	US Patent	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description JAK2 (IC50): Recombinant human JAK2 catalytic domain (amino acids 808-1132; catalog number PV4210) is purchased from Invitrogen. 0.025 mU of JAK2 is ...				US Patent US10708263 (2020)
GALAPAGOS NV US Patent					More data for this Ligand-Target Pair
TYK2 (aa 871-1187) (Homo sapiens (Human))	BDBM103727 (US10112907, Example 00033 \| US10206907, Compound 2...) Show SMILES Show InChI	PDB GoogleScholar	Purchase PC cid PC sid PDB UniChem Similars	US Patent	n/a	n/a	n/a	376	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description JAK3 (IC50): Recombinant human JAK3 catalytic domain (amino acids 781-1124; catalog number PV3855) is purchased from Invitrogen. 0.025 mU of JAK3 is ...				US Patent US10708263 (2020)
GALAPAGOS NV US Patent					More data for this Ligand-Target Pair

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Change energy units to:kcal/mole

* indicates data uncertainty>20%