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Found 3 Enz. Inhib. hit(s) with all data for entry = 9853
TargetAndrogen receptor(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM493530(5-[5-oxo-8-[6-(4-piperidyloxy)- 3-pyridyl]-7-thiox...)
Affinity DataKi:  3nMAssay Description:ReceptorsGR (human) (agonist radioligand) IM-9 cells (cytosol)[3H]dexamethasone 1.5 nM 1.5 nM triamcinolone (10 μM) 6 h 4° C. Scintillation coun...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAndrogen receptor(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM493530(5-[5-oxo-8-[6-(4-piperidyloxy)- 3-pyridyl]-7-thiox...)
Affinity DataIC50:  6.90nMAssay Description:ReceptorsGR (human) (agonist radioligand) IM-9 cells (cytosol)[3H]dexamethasone 1.5 nM 1.5 nM triamcinolone (10 μM) 6 h 4° C. Scintillation coun...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlucocorticoid receptor(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM493530(5-[5-oxo-8-[6-(4-piperidyloxy)- 3-pyridyl]-7-thiox...)
Affinity DataIC50: >3.00E+4nMAssay Description:ReceptorsGR (human) (agonist radioligand) IM-9 cells (cytosol)[3H]dexamethasone 1.5 nM 1.5 nM triamcinolone (10 μM) 6 h 4° C. Scintillation coun...More data for this Ligand-Target Pair
In DepthDetails US Patent